| 2005-04-05 | @ ANA | 1 | L 2-3 | 0-1 | 4 | 43,590 | Ryan Drese | Bartolo Colon | Bartolo Colon | Ryan Drese | Francisco Rodriguez | 2 | 3 | -1 |
| 2005-04-06 | @ ANA | 2 | W 3-2 | 1-1 | 2 | 35,077 | Kenny Rogers | Jarrod Washburn | Brian Shouse | Bret Prinz | | 5 | 5 | 0 |
| 2005-04-07 | @ ANA | 3 | L 6-7 | 1-2 | 4 | 35,169 | Chris Young | John Lackey | Scot Shields | Brian Shouse | | 11 | 12 | -1 |
| 2005-04-08 | @ SEA | 4 | L 6-9 | 1-3 | 4 | 29,652 | Chan Ho Park | Aaron Sele | J.J. Putz | Nick Regilio | Eddie Guardado | 17 | 21 | -4 |
| 2005-04-09 | @ SEA | 5 | W 7-6 | 2-3 | 4 | 31,501 | Pedro Astacio | Jamie Moyer | Doug Brocail | Eddie Guardado | Francisco Cordero | 24 | 27 | -3 |
| 2005-04-10 | @ SEA | 6 | W 7-6 | 3-3 | 2 | 30,434 | Ryan Drese | Gil Meche | Matt Riley | Matt Thornton | Francisco Cordero | 31 | 33 | -2 |
| 2005-04-11 | vs ANA | 7 | L 6-7 | 3-4 | 4 | 50,054 | Kenny Rogers | Jarrod Washburn | Scot Shields | R.A. Dickey | Francisco Rodriguez | 37 | 40 | -3 |
| 2005-04-12 | vs ANA | 8 | L 8-13 | 3-5 | 4 | 23,061 | Chris Young | John Lackey | John Lackey | Chris Young | Scot Shields | 45 | 53 | -8 |
| 2005-04-13 | vs ANA | 9 | W 7-5 | 4-5 | 4 | 21,625 | Chan Ho Park | Paul Byrd | Chan Ho Park | Paul Byrd | Francisco Cordero | 52 | 58 | -6 |
| 2005-04-14 | vs TOR | 10 | L 1-2 | 4-6 | 4 | 19,366 | Pedro Astacio | Roy Halladay | Roy Halladay | Pedro Astacio | | 53 | 60 | -7 |
| 2005-04-15 | vs TOR | 11 | W 4-2 | 5-6 | 3 | 30,453 | Ryan Drese | Ted Lilly | Ryan Drese | Ted Lilly | Francisco Cordero | 57 | 62 | -5 |
| 2005-04-16 | vs TOR | 12 | L 0-8 | 5-7 | 4 | 40,499 | Kenny Rogers | Gustavo Chacin | Gustavo Chacin | Kenny Rogers | | 57 | 70 | -13 |
| 2005-04-17 | vs TOR | 13 | W 6-5 | 6-7 | 4 | 31,310 | Chris Young | Josh Towers | Chris Young | Josh Towers | Francisco Cordero | 63 | 75 | -12 |
| 2005-04-18 | vs OAK | 14 | L 5-8 | 6-8 | 4 | 20,939 | Chan Ho Park | Dan Haren | Dan Haren | Chan Ho Park | Octavio Dotel | 68 | 83 | -15 |
| 2005-04-19 | vs OAK | 15 | W 3-0 | 7-8 | 4 | 22,146 | Pedro Astacio | Joe Blanton | Pedro Astacio | Joe Blanton | Francisco Cordero | 71 | 83 | -12 |
| 2005-04-20 | @ TBA | 16 | W 12-10 | 8-8 | 3 | 8,816 | Ryan Drese | John Webb | Ryan Drese | John Webb | Francisco Cordero | 83 | 93 | -10 |
| 2005-04-21 | @ TBA | 17 | L 2-3 | 8-9 | 4 | 8,799 | Kenny Rogers | Dewon Brazelton | Dewon Brazelton | Kenny Rogers | Danys Baez | 85 | 96 | -11 |
| 2005-04-22 | @ NYA | 18 | W 5-3 | 9-9 | 3 | 42,710 | Chris Young | Kevin Brown | Chris Young | Kevin Brown | Francisco Cordero | 90 | 99 | -9 |
| 2005-04-23 | @ NYA | 19 | W 10-2 | 10-9 | 2 | 44,731 | Chan Ho Park | Jaret Wright | Chan Ho Park | Jaret Wright | | 100 | 101 | -1 |
| 2005-04-24 | @ NYA | 20 | L 1-11 | 10-10 | 2 | 42,732 | Pedro Astacio | Randy Johnson | Randy Johnson | Pedro Astacio | | 101 | 112 | -11 |
| 2005-04-26 | vs SEA | 21 | L 4-7 | 10-11 | 4 | 23,064 | Ryan Drese | Joel Pineiro | Joel Pineiro | Ryan Drese | Eddie Guardado | 105 | 119 | -14 |
| 2005-04-27 | vs SEA | 22 | W 8-2 | 11-11 | 3 | 26,308 | Kenny Rogers | Ryan Franklin | Kenny Rogers | Ryan Franklin | | 113 | 121 | -8 |
| 2005-04-28 | vs SEA | 23 | L 1-4 | 11-12 | 4 | 23,928 | Chris Young | Gil Meche | Gil Meche | Chris Young | Eddie Guardado | 114 | 125 | -11 |
| 2005-04-29 | vs BOS | 24 | W 7-2 | 12-12 | 3 | 43,933 | Chan Ho Park | Tim Wakefield | Chan Ho Park | Tim Wakefield | Ron Mahay | 121 | 127 | -6 |
| 2005-04-30 | vs BOS | 25 | L 2-9 | 12-13 | 4 | 44,114 | Pedro Astacio | Bronson Arroyo | Bronson Arroyo | Pedro Astacio | | 123 | 136 | -13 |
| 2005-05-01 | vs BOS | 26 | L 5-6 | 12-14 | 4 | 49,342 | Ryan Drese | Matt Clement | Matt Clement | Ryan Drese | Keith Foulke | 128 | 142 | -14 |
| 2005-05-02 | @ OAK | 27 | W 3-2 | 13-14 | 3 | 10,144 | Kenny Rogers | Rich Harden | Kenny Rogers | Rich Harden | Francisco Cordero | 131 | 144 | -13 |
| 2005-05-03 | @ OAK | 28 | W 6-1 | 14-14 | 2 | 10,427 | Chris Young | Kirk Saarloos | Chris Young | Kirk Saarloos | | 137 | 145 | -8 |
| 2005-05-04 | @ OAK | 29 | W 16-7 | 15-14 | 2 | 15,654 | Chan Ho Park | Dan Haren | Brian Shouse | Dan Haren | | 153 | 152 | 1 |
| 2005-05-06 | vs CLE | 30 | L 6-8 | 15-15 | 2 | 30,742 | Pedro Astacio | Cliff Lee | Cliff Lee | Pedro Astacio | Bob Wickman | 159 | 160 | -1 |
| 2005-05-07 | vs CLE | 31 | W 6-1 | 16-15 | 2 | 36,311 | Ryan Drese | Scott Elarton | Ryan Drese | Scott Elarton | | 165 | 161 | 4 |
| 2005-05-08 | vs CLE | 32 | W 7-2 | 17-15 | 2 | 23,203 | Kenny Rogers | Jake Westbrook | Kenny Rogers | Jake Westbrook | Francisco Cordero | 172 | 163 | 9 |
| 2005-05-09 | vs DET | 33 | L 0-2 | 17-16 | 2 | 24,122 | Chris Young | Nate Robertson | Nate Robertson | Francisco Cordero | Ugueth Urbina | 172 | 165 | 7 |
| 2005-05-10 | vs DET | 34 | W 5-4 | 18-16 | 2 | 24,766 | Chan Ho Park | Jason Johnson | Doug Brocail | Jason Johnson | Francisco Cordero | 177 | 169 | 8 |
| 2005-05-11 | vs DET | 35 | L 5-6 | 18-17 | 2 | 28,689 | Pedro Astacio | Wil Ledezma | Jamie Walker | Ron Mahay | Ugueth Urbina | 182 | 175 | 7 |
| 2005-05-13 | @ MIN | 36 | W 9-6 | 19-17 | 2 | 24,524 | Ryan Drese | Joe Mays | Doug Brocail | Joe Nathan | Francisco Cordero | 191 | 181 | 10 |
| 2005-05-14 | @ MIN | 37 | W 5-0 | 20-17 | 2 | 28,624 | Kenny Rogers | Carlos Silva | Kenny Rogers | Carlos Silva | | 196 | 181 | 15 |
| 2005-05-15 | @ MIN | 38 | L 2-5 | 20-18 | 2 | 27,891 | Chris Young | Brad Radke | Brad Radke | Ron Mahay | Joe Nathan | 198 | 186 | 12 |
| 2005-05-16 | @ CHA | 39 | W 7-6 | 21-18 | 2 | 26,889 | Chan Ho Park | Orlando Hernandez | Nick Regilio | Damaso Marte | Francisco Cordero | 205 | 192 | 13 |
| 2005-05-17 | @ CHA | 40 | L 2-5 | 21-19 | 2 | 18,333 | Pedro Astacio | Jon Garland | Jon Garland | Pedro Astacio | Dustin Hermanson | 207 | 197 | 10 |
| 2005-05-18 | @ CHA | 41 | L 0-7 | 21-20 | 2 | 16,255 | Ryan Drese | Mark Buehrle | Mark Buehrle | Ryan Drese | | 207 | 204 | 3 |
| 2005-05-20 | vs HOU | 42 | W 7-3 | 22-20 | 2 | 38,109 | Kenny Rogers | Brandon Backe | Kenny Rogers | Brandon Backe | | 214 | 207 | 7 |
| 2005-05-21 | vs HOU | 43 | W 18-3 | 23-20 | 2 | 35,781 | Chris Young | Ezequiel Astacio | Chris Young | Ezequiel Astacio | | 232 | 210 | 22 |
| 2005-05-22 | vs HOU | 44 | W 2-0 | 24-20 | 2 | 40,583 | Chan Ho Park | Roy Oswalt | Chan Ho Park | Roy Oswalt | Francisco Cordero | 234 | 210 | 24 |
| 2005-05-24 | vs KCA | 45 | W 4-3 | 25-20 | 2 | 27,449 | Ryan Drese | Runelvys Hernandez | Ryan Drese | Runelvys Hernandez | Francisco Cordero | 238 | 213 | 25 |
| 2005-05-25 | vs KCA | 46 | W 7-3 | 26-20 | 1 | 23,755 | Pedro Astacio | Zack Greinke | Pedro Astacio | Zack Greinke | | 245 | 216 | 29 |
| 2005-05-26 | vs KCA | 47 | W 8-1 | 27-20 | 1 | 25,022 | Kenny Rogers | Jose Lima | Kenny Rogers | Jose Lima | | 253 | 217 | 36 |
| 2005-05-27 | vs CHA | 48 | W 6-2 | 28-20 | 1 | 31,149 | Chris Young | Brandon McCarthy | Chris Young | Brandon McCarthy | Francisco Cordero | 259 | 219 | 40 |
| 2005-05-29 | vs CHA | 49 | W 12-4 | 29-20 | 2 | 36,265 | Chan Ho Park | Jon Garland | Chan Ho Park | Jon Garland | | 271 | 223 | 48 |
| 2005-05-31 | @ DET | 50 | W 8-2 | 30-20 | 1 | 16,931 | Kenny Rogers | Mike Maroth | Kenny Rogers | Mike Maroth | | 279 | 225 | 54 |
| 2005-06-01 | @ DET | 51 | L 4-6 | 30-21 | 1 | 15,428 | Ryan Drese | Jeremy Bonderman | Jeremy Bonderman | Ryan Drese | Ugueth Urbina | 283 | 231 | 52 |
| 2005-06-02 | @ DET | 52 | L 5-6 | 30-22 | 2 | 21,166 | Chris Young | Nate Robertson | Ugueth Urbina | Nick Regilio | | 288 | 237 | 51 |
| 2005-06-03 | @ KCA | 53 | L 1-2 | 30-23 | 2 | 11,635 | Pedro Astacio | Runelvys Hernandez | Andy Sisco | Pedro Astacio | Mike MacDougal | 289 | 239 | 50 |
| 2005-06-04 | @ KCA | 54 | W 14-9 | 31-23 | 2 | 18,808 | Chan Ho Park | Jose Lima | Chan Ho Park | Jose Lima | | 303 | 248 | 55 |
| 2005-06-05 | @ KCA | 55 | W 8-1 | 32-23 | 1 | 21,424 | Kenny Rogers | Zack Greinke | Kenny Rogers | Zack Greinke | | 311 | 249 | 62 |
| 2005-06-07 | @ PHI | 56 | L 5-8 | 32-24 | 1 | 33,616 | Ryan Drese | Jon Lieber | Jon Lieber | Ryan Drese | Billy Wagner | 316 | 257 | 59 |
| 2005-06-08 | @ PHI | 57 | L 0-2 | 32-25 | 2 | 24,339 | Chris Young | Rob Tejeda | Aaron Fultz | Chris Young | Billy Wagner | 316 | 259 | 57 |
| 2005-06-09 | @ PHI | 58 | L 8-10 | 32-26 | 2 | 25,205 | Pedro Astacio | Vicente Padilla | Vicente Padilla | Pedro Astacio | Billy Wagner | 324 | 269 | 55 |
| 2005-06-10 | @ FLO | 59 | L 5-12 | 32-27 | 2 | 16,622 | Chan Ho Park | A.J. Burnett | Todd Jones | Doug Brocail | | 329 | 281 | 48 |
| 2005-06-11 | @ FLO | 60 | L 5-6 | 32-28 | 2 | 25,557 | Kenny Rogers | Al Leiter | John Riedling | Juan Dominguez | Todd Jones | 334 | 287 | 47 |
| 2005-06-12 | @ FLO | 61 | W 6-2 | 33-28 | 2 | 21,303 | Ricardo Rodriguez | Brian Moehler | Ricardo Rodriguez | Brian Moehler | John Wasdin | 340 | 289 | 51 |
| 2005-06-13 | vs ATL | 62 | W 7-3 | 34-28 | 2 | 41,594 | Chris Young | Tim Hudson | Chris Young | Tim Hudson | | 347 | 292 | 55 |
| 2005-06-14 | vs ATL | 63 | L 2-7 | 34-29 | 2 | 30,221 | Pedro Astacio | Jorge Sosa | Jorge Sosa | Pedro Astacio | | 349 | 299 | 50 |
| 2005-06-15 | vs ATL | 64 | W 9-5 | 35-29 | 2 | 33,663 | Chan Ho Park | Kyle Davies | Chan Ho Park | Kyle Davies | Francisco Cordero | 358 | 304 | 54 |
| 2005-06-17 | vs WAS | 65 | W 8-1 | 36-29 | 2 | 33,653 | Kenny Rogers | John Patterson | Kenny Rogers | John Patterson | | 366 | 305 | 61 |
| 2005-06-18 | vs WAS | 66 | W 7-4 | 37-29 | 2 | 48,663 | Ricardo Rodriguez | Tony Armas | Ricardo Rodriguez | Tony Armas | | 373 | 309 | 64 |
| 2005-06-19 | vs WAS | 67 | L 2-8 | 37-30 | 2 | 34,474 | C.J. Wilson | Sun-Woo Kim | Travis Hughes | C.J. Wilson | | 375 | 317 | 58 |
| 2005-06-20 | @ ANA | 68 | L 1-5 | 37-31 | 2 | 41,007 | Chris Young | Paul Byrd | Paul Byrd | Chris Young | | 376 | 322 | 54 |
| 2005-06-21 | @ ANA | 69 | L 6-8 | 37-32 | 2 | 43,025 | Chan Ho Park | Bartolo Colon | Bartolo Colon | Chan Ho Park | | 382 | 330 | 52 |
| 2005-06-22 | @ ANA | 70 | L 0-6 | 37-33 | 2 | 41,763 | Kenny Rogers | Jarrod Washburn | Jarrod Washburn | Kenny Rogers | | 382 | 336 | 46 |
| 2005-06-24 | @ HOU | 71 | L 2-5 | 37-34 | 2 | 36,199 | Ricardo Rodriguez | Roy Oswalt | Roy Oswalt | Ricardo Rodriguez | Brad Lidge | 384 | 341 | 43 |
| 2005-06-25 | @ HOU | 72 | W 6-5 | 38-34 | 2 | 41,868 | Chris Young | Brandon Backe | Chris Young | Brandon Backe | Francisco Cordero | 390 | 346 | 44 |
| 2005-06-26 | @ HOU | 73 | L 2-3 | 38-35 | 2 | 35,331 | Chan Ho Park | Andy Pettitte | Chad Qualls | Juan Dominguez | | 392 | 349 | 43 |
| 2005-06-27 | vs ANA | 74 | L 3-13 | 38-36 | 2 | 34,471 | C.J. Wilson | Bartolo Colon | Bartolo Colon | C.J. Wilson | | 395 | 362 | 33 |
| 2005-06-28 | vs ANA | 75 | L 1-5 | 38-37 | 2 | 27,159 | John Wasdin | Jarrod Washburn | Brendan Donnelly | Kameron Loe | | 396 | 367 | 29 |
| 2005-06-29 | vs ANA | 76 | W 7-6 | 39-37 | 2 | 30,112 | Ricardo Rodriguez | John Lackey | Kameron Loe | Scot Shields | | 403 | 373 | 30 |
| 2005-06-30 | vs ANA | 77 | W 18-5 | 40-37 | 2 | 27,466 | Chris Young | Ervin Santana | Chris Young | Ervin Santana | | 421 | 378 | 43 |
| 2005-07-01 | @ SEA | 78 | W 6-2 | 41-37 | 2 | 37,270 | Chan Ho Park | Aaron Sele | Chan Ho Park | Aaron Sele | | 427 | 380 | 47 |
| 2005-07-02 | @ SEA | 79 | W 6-5 | 42-37 | 2 | 34,209 | C.J. Wilson | Joel Pineiro | Kameron Loe | J.J. Putz | Francisco Cordero | 433 | 385 | 48 |
| 2005-07-03 | @ SEA | 80 | L 1-2 | 42-38 | 2 | 34,397 | Kenny Rogers | Jamie Moyer | Jamie Moyer | Kenny Rogers | Eddie Guardado | 434 | 387 | 47 |
| 2005-07-04 | vs BOS | 81 | W 6-5 | 43-38 | 2 | 50,492 | Ricardo Rodriguez | Wade Miller | Joaquin Benoit | Keith Foulke | | 440 | 392 | 48 |
| 2005-07-05 | vs BOS | 82 | L 4-7 | 43-39 | 2 | 33,356 | Chris Young | Tim Wakefield | Tim Wakefield | Chris Young | Mike Timlin | 444 | 399 | 45 |
| 2005-07-06 | vs BOS | 83 | L 4-7 | 43-40 | 2 | 34,962 | Chan Ho Park | Matt Clement | Matt Clement | Chan Ho Park | Alan Embree | 448 | 406 | 42 |
| 2005-07-08 | vs TOR | 84 | W 7-6 | 44-40 | 2 | 30,242 | John Wasdin | Roy Halladay | Francisco Cordero | Miguel Batista | | 455 | 412 | 43 |
| 2005-07-09 | vs TOR | 85 | W 12-10 | 45-40 | 2 | 36,285 | Kenny Rogers | Scott Downs | Kenny Rogers | Scott Downs | Francisco Cordero | 467 | 422 | 45 |
| 2005-07-10 | vs TOR | 86 | W 9-8 | 46-40 | 2 | 25,767 | Chris Young | Josh Towers | Kameron Loe | Jason Frasor | | 476 | 430 | 46 |
| 2005-07-14 | @ OAK | 87 | L 0-6 | 46-41 | 2 | 17,987 | Chan Ho Park | Rich Harden | Rich Harden | Chan Ho Park | | 476 | 436 | 40 |
| 2005-07-15 | @ OAK | 88 | L 2-7 | 46-42 | 2 | 22,423 | John Wasdin | Barry Zito | Barry Zito | John Wasdin | | 478 | 443 | 35 |
| 2005-07-16 | @ OAK | 89 | W 10-8 | 47-42 | 2 | 22,826 | Kenny Rogers | Joe Blanton | Kenny Rogers | Joe Blanton | Francisco Cordero | 488 | 451 | 37 |
| 2005-07-17 | @ OAK | 90 | L 4-5 | 47-43 | 2 | 25,330 | Chris Young | Dan Haren | Joe Kennedy | Kameron Loe | | 492 | 456 | 36 |
| 2005-07-18 | vs NYA | 91 | L 10-11 | 47-44 | 2 | 46,538 | Ricardo Rodriguez | Kevin Brown | Tanyon Sturtze | Doug Brocail | Mariano Rivera | 502 | 467 | 35 |
| 2005-07-19 | vs NYA | 92 | W 2-1 | 48-44 | 2 | 45,208 | Chan Ho Park | Mike Mussina | Kameron Loe | Wayne Franklin | Francisco Cordero | 504 | 468 | 36 |
| 2005-07-20 | vs NYA | 93 | L 4-8 | 48-45 | 3 | 45,354 | Joaquin Benoit | Aaron Small | Aaron Small | Joaquin Benoit | | 508 | 476 | 32 |
| 2005-07-21 | vs OAK | 94 | L 4-6 | 48-46 | 3 | 31,643 | Kenny Rogers | Joe Blanton | Jay Witasick | Kameron Loe | Huston Street | 512 | 482 | 30 |
| 2005-07-22 | vs OAK | 95 | L 10-11 | 48-47 | 3 | 35,266 | Chris Young | Dan Haren | Dan Haren | Chris Young | Justin Duchscherer | 522 | 493 | 29 |
| 2005-07-23 | vs OAK | 96 | L 4-5 | 48-48 | 3 | 38,841 | Ricardo Rodriguez | Kirk Saarloos | Kirk Saarloos | Ricardo Rodriguez | Huston Street | 526 | 498 | 28 |
| 2005-07-24 | vs OAK | 97 | L 3-8 | 48-49 | 3 | 29,410 | Chan Ho Park | Rich Harden | Rich Harden | Chan Ho Park | | 529 | 506 | 23 |
| 2005-07-25 | @ BAL | 98 | W 4-2 | 49-49 | 3 | 29,314 | Joaquin Benoit | Daniel Cabrera | Joaquin Benoit | Daniel Cabrera | Francisco Cordero | 533 | 508 | 25 |
| 2005-07-26 | @ BAL | 99 | L 4-5 | 49-50 | 3 | 25,235 | Kenny Rogers | Rodrigo Lopez | Jason Grimsley | James Baldwin | B.J. Ryan | 537 | 513 | 24 |
| 2005-07-27 | @ BAL | 100 | W 11-8 | 50-50 | 3 | 31,540 | Chris Young | Bruce Chen | Francisco Cordero | Jorge Julio | James Baldwin | 548 | 521 | 27 |
| 2005-07-28 | @ BAL | 101 | W 2-1 | 51-50 | 3 | 22,254 | Ricardo Rodriguez | Sidney Ponson | Kameron Loe | Chris Ray | Francisco Cordero | 550 | 522 | 28 |
| 2005-07-29 | @ TOR | 102 | W 4-1 | 52-50 | 3 | 21,113 | John Wasdin | Scott Downs | Doug Brocail | Scott Downs | Francisco Cordero | 554 | 523 | 31 |
| 2005-07-30 | @ TOR | 103 | W 3-2 | 53-50 | 3 | 23,039 | Joaquin Benoit | Dustin McGowan | Joaquin Benoit | Jason Frasor | Francisco Cordero | 557 | 525 | 32 |
| 2005-07-31 | @ TOR | 104 | L 1-5 | 53-51 | 3 | 24,123 | C.J. Wilson | Gustavo Chacin | Gustavo Chacin | C.J. Wilson | | 558 | 530 | 28 |
| 2005-08-02 | vs TBA | 105 | L 8-10 | 53-52 | 3 | 30,038 | Chris Young | Seth McClung | Seth McClung | Chris Young | Danys Baez | 566 | 540 | 26 |
| 2005-08-03 | vs TBA | 106 | L 5-8 | 53-53 | 3 | 30,513 | Ricardo Rodriguez | Scott Kazmir | Travis Harper | Ricardo Rodriguez | Danys Baez | 571 | 548 | 23 |
| 2005-08-04 | vs TBA | 107 | W 13-5 | 54-53 | 3 | 27,176 | Joaquin Benoit | Casey Fossum | Kevin Gryboski | Chad Orvella | | 584 | 553 | 31 |
| 2005-08-05 | vs BAL | 108 | L 5-10 | 54-54 | 3 | 37,296 | C.J. Wilson | Bruce Chen | Bruce Chen | C.J. Wilson | | 589 | 563 | 26 |
| 2005-08-06 | vs BAL | 109 | W 10-3 | 55-54 | 3 | 34,632 | John Wasdin | Daniel Cabrera | John Wasdin | Daniel Cabrera | Kameron Loe | 599 | 566 | 33 |
| 2005-08-07 | vs BAL | 110 | W 9-3 | 56-54 | 3 | 27,137 | Chris Young | Sidney Ponson | Chris Young | Sidney Ponson | | 608 | 569 | 39 |
| 2005-08-08 | @ BOS | 111 | L 6-11 | 56-55 | 3 | 35,453 | Ricardo Rodriguez | Wade Miller | Geremi Gonzalez | Steve Karsay | | 614 | 580 | 34 |
| 2005-08-09 | @ BOS | 112 | L 7-8 | 56-56 | 3 | 35,308 | Joaquin Benoit | Matt Clement | Curt Schilling | Kevin Gryboski | | 621 | 588 | 33 |
| 2005-08-10 | @ BOS | 113 | L 5-16 | 56-57 | 3 | 35,379 | Kenny Rogers | Bronson Arroyo | Bronson Arroyo | Kenny Rogers | | 626 | 604 | 22 |
| 2005-08-11 | @ NYA | 114 | L 8-9 | 56-58 | 3 | 54,283 | John Wasdin | Scott Proctor | Tanyon Sturtze | James Baldwin | Mariano Rivera | 634 | 613 | 21 |
| 2005-08-12 | @ NYA | 115 | L 5-6 | 56-59 | 3 | 54,442 | Chris Young | Al Leiter | Al Leiter | C.J. Wilson | Tanyon Sturtze | 639 | 619 | 20 |
| 2005-08-13 | @ NYA | 116 | L 5-7 | 56-60 | 3 | 54,919 | Juan Dominguez | Mike Mussina | Aaron Small | Kameron Loe | | 644 | 626 | 18 |
| 2005-08-14 | @ NYA | 117 | L 3-10 | 56-61 | 3 | 54,824 | Joaquin Benoit | Shawn Chacon | Shawn Chacon | Joaquin Benoit | | 647 | 636 | 11 |
| 2005-08-16 | @ CLE | 118 | L 2-8 | 56-62 | 3 | 27,403 | Kenny Rogers | CC Sabathia | CC Sabathia | Kenny Rogers | | 649 | 644 | 5 |
| 2005-08-17 | @ CLE | 119 | W 3-0 | 57-62 | 3 | 20,442 | Chris Young | Kevin Millwood | Chris Young | Kevin Millwood | Francisco Cordero | 652 | 644 | 8 |
| 2005-08-18 | @ CLE | 120 | L 4-9 | 57-63 | 3 | 23,214 | C.J. Wilson | Jake Westbrook | Jake Westbrook | C.J. Wilson | | 656 | 653 | 3 |
| 2005-08-19 | @ TBA | 121 | L 1-2 | 57-64 | 3 | 10,188 | Juan Dominguez | Seth McClung | Seth McClung | Juan Dominguez | Danys Baez | 657 | 655 | 2 |
| 2005-08-20 | @ TBA | 122 | L 2-4 | 57-65 | 3 | 19,041 | Joaquin Benoit | Scott Kazmir | Scott Kazmir | Joaquin Benoit | Danys Baez | 659 | 659 | 0 |
| 2005-08-21 | @ TBA | 123 | L 3-6 | 57-66 | 3 | 13,974 | Kenny Rogers | Casey Fossum | Casey Fossum | Kenny Rogers | Danys Baez | 662 | 665 | -3 |
| 2005-08-23 | vs SEA | 124 | W 6-4 | 58-66 | 3 | 25,653 | Chris Young | Jamie Moyer | Chris Young | Jamie Moyer | Francisco Cordero | 668 | 669 | -1 |
| 2005-08-24 | vs SEA | 125 | W 8-1 | 59-66 | 3 | 28,612 | Juan Dominguez | Ryan Franklin | Juan Dominguez | Ryan Franklin | John Wasdin | 676 | 670 | 6 |
| 2005-08-25 | vs SEA | 126 | L 2-8 | 59-67 | 3 | 19,112 | Joaquin Benoit | Jeff Harris | Jeff Harris | Joaquin Benoit | | 678 | 678 | 0 |
| 2005-08-26 | vs MIN | 127 | W 6-0 | 60-67 | 3 | 28,877 | Kameron Loe | Kyle Lohse | Kameron Loe | Kyle Lohse | C.J. Wilson | 684 | 678 | 6 |
| 2005-08-27 | vs MIN | 128 | L 2-7 | 60-68 | 3 | 25,351 | Kenny Rogers | Brad Radke | Joe Nathan | Brian Shouse | | 686 | 685 | 1 |
| 2005-08-28 | vs MIN | 129 | W 2-1 | 61-68 | 3 | 20,882 | Chris Young | Johan Santana | Doug Brocail | Jesse Crain | | 688 | 686 | 2 |
| 2005-08-29 | vs CHA | 130 | W 7-5 | 62-68 | 3 | 27,819 | Juan Dominguez | Mark Buehrle | Juan Dominguez | Mark Buehrle | Doug Brocail | 695 | 691 | 4 |
| 2005-08-30 | vs CHA | 131 | W 8-6 | 63-69 | 3 | 0 | Joaquin Benoit | Jon Garland | C.J. Wilson | Jon Garland | Francisco Cordero | 703 | 697 | 6 |
| 2005-08-30 | vs CHA | 132 | L 0-8 | 63-69 | 3 | 28,183 | Edinson Volquez | Brandon McCarthy | Brandon McCarthy | Edinson Volquez | | 703 | 705 | -2 |
| 2005-08-31 | vs CHA | 133 | W 9-2 | 64-69 | 3 | 23,493 | Kameron Loe | Orlando Hernandez | Kameron Loe | Orlando Hernandez | | 712 | 707 | 5 |
| 2005-09-01 | @ KCA | 134 | W 5-4 | 65-69 | 3 | 12,735 | Kenny Rogers | J.P. Howell | Kenny Rogers | J.P. Howell | Francisco Cordero | 717 | 711 | 6 |
| 2005-09-02 | @ KCA | 135 | W 8-7 | 66-69 | 3 | 14,425 | Chris Young | Zack Greinke | Francisco Cordero | Mike MacDougal | John Wasdin | 725 | 718 | 7 |
| 2005-09-03 | @ KCA | 136 | W 5-3 | 67-69 | 3 | 18,932 | Juan Dominguez | D.J. Carrasco | Juan Dominguez | D.J. Carrasco | | 730 | 721 | 9 |
| 2005-09-04 | @ KCA | 137 | L 8-17 | 67-70 | 3 | 15,512 | Edinson Volquez | Jimmy Gobble | Leo Nunez | Edinson Volquez | | 738 | 738 | 0 |
| 2005-09-05 | @ MIN | 138 | W 7-0 | 68-70 | 3 | 15,627 | Kameron Loe | Carlos Silva | Kameron Loe | Carlos Silva | | 745 | 738 | 7 |
| 2005-09-06 | @ MIN | 139 | W 10-7 | 69-70 | 3 | 12,564 | Kenny Rogers | Kyle Lohse | John Wasdin | Joe Nathan | Francisco Cordero | 755 | 745 | 10 |
| 2005-09-07 | @ MIN | 140 | L 6-8 | 69-71 | 3 | 13,034 | Chris Young | Brad Radke | J.C. Romero | Doug Brocail | Joe Nathan | 761 | 753 | 8 |
| 2005-09-09 | vs OAK | 141 | L 8-9 | 69-72 | 3 | 26,468 | Juan Dominguez | Barry Zito | Barry Zito | Juan Dominguez | Huston Street | 769 | 762 | 7 |
| 2005-09-10 | vs OAK | 142 | L 4-5 | 69-73 | 3 | 41,058 | Kameron Loe | Joe Blanton | Joe Blanton | Kameron Loe | Huston Street | 773 | 767 | 6 |
| 2005-09-11 | vs OAK | 143 | W 7-4 | 70-73 | 3 | 19,913 | Kenny Rogers | Joe Kennedy | Kenny Rogers | Joe Kennedy | John Wasdin | 780 | 771 | 9 |
| 2005-09-12 | vs BAL | 144 | L 2-4 | 70-74 | 3 | 20,418 | Edinson Volquez | Daniel Cabrera | Daniel Cabrera | Edinson Volquez | B.J. Ryan | 782 | 775 | 7 |
| 2005-09-13 | vs BAL | 145 | L 3-4 | 70-75 | 3 | 21,167 | R.A. Dickey | John Maine | Chris Ray | C.J. Wilson | B.J. Ryan | 785 | 779 | 6 |
| 2005-09-14 | vs BAL | 146 | W 7-6 | 71-75 | 3 | 18,077 | Juan Dominguez | Erik Bedard | Joaquin Benoit | Jason Grimsley | | 792 | 785 | 7 |
| 2005-09-15 | vs SEA | 147 | W 4-3 | 72-75 | 3 | 23,679 | Kameron Loe | Jeff Harris | Kameron Loe | Jeff Harris | Francisco Cordero | 796 | 788 | 8 |
| 2005-09-16 | vs SEA | 148 | W 5-3 | 73-75 | 3 | 25,567 | Josh Rupe | Felix Hernandez | Josh Rupe | Felix Hernandez | Francisco Cordero | 801 | 791 | 10 |
| 2005-09-17 | vs SEA | 149 | W 7-6 | 74-75 | 3 | 41,983 | Kenny Rogers | Joel Pineiro | Brian Shouse | Eddie Guardado | | 808 | 797 | 11 |
| 2005-09-18 | vs SEA | 150 | W 8-6 | 75-75 | 3 | 26,532 | R.A. Dickey | Ryan Franklin | R.A. Dickey | Ryan Franklin | Francisco Cordero | 816 | 803 | 13 |
| 2005-09-20 | @ ANA | 151 | L 1-2 | 75-76 | 3 | 36,170 | Juan Dominguez | Bartolo Colon | Bartolo Colon | Juan Dominguez | Francisco Rodriguez | 817 | 805 | 12 |
| 2005-09-21 | @ ANA | 152 | L 5-6 | 75-77 | 3 | 37,776 | Kameron Loe | John Lackey | Esteban Yan | Scott Feldman | Francisco Rodriguez | 822 | 811 | 11 |
| 2005-09-22 | @ ANA | 153 | L 4-7 | 75-78 | 3 | 36,588 | Chris Young | Ervin Santana | Ervin Santana | Edinson Volquez | Kelvim Escobar | 826 | 818 | 8 |
| 2005-09-23 | @ OAK | 154 | W 3-1 | 76-78 | 3 | 33,402 | Kenny Rogers | Dan Haren | Kenny Rogers | Dan Haren | Francisco Cordero | 829 | 819 | 10 |
| 2005-09-24 | @ OAK | 155 | L 6-7 | 76-79 | 3 | 26,704 | R.A. Dickey | Barry Zito | Justin Duchscherer | John Wasdin | Huston Street | 835 | 826 | 9 |
| 2005-09-25 | @ OAK | 156 | W 6-2 | 77-79 | 3 | 27,709 | Juan Dominguez | Kirk Saarloos | Juan Dominguez | Kirk Saarloos | | 841 | 828 | 13 |
| 2005-09-27 | @ SEA | 157 | W 3-2 | 78-79 | 3 | 22,739 | Kameron Loe | Felix Hernandez | John Wasdin | Julio Mateo | Francisco Cordero | 844 | 830 | 14 |
| 2005-09-28 | @ SEA | 158 | W 7-3 | 79-79 | 3 | 20,723 | Chris Young | Joel Pineiro | Chris Young | Joel Pineiro | Francisco Cordero | 851 | 833 | 18 |
| 2005-09-29 | @ SEA | 159 | L 3-4 | 79-80 | 3 | 19,481 | Kenny Rogers | Ryan Franklin | Ryan Franklin | Kenny Rogers | Eddie Guardado | 854 | 837 | 17 |
| 2005-09-30 | vs ANA | 160 | L 1-7 | 79-81 | 3 | 38,187 | R.A. Dickey | John Lackey | John Lackey | R.A. Dickey | | 855 | 844 | 11 |
| 2005-10-01 | vs ANA | 161 | L 6-7 | 79-82 | 3 | 48,174 | Juan Dominguez | Jarrod Washburn | Scot Shields | Juan Dominguez | Francisco Rodriguez | 861 | 851 | 10 |
| 2005-10-02 | vs ANA | 162 | L 4-7 | 79-83 | 3 | 38,334 | Kameron Loe | Ervin Santana | Ervin Santana | Kameron Loe | Francisco Rodriguez | 865 | 858 | 7 |