| 2005-04-04 | vs TOR | 1 | L 2-5 | 0-1 | 5 | 26,018 | Dewon Brazelton | Roy Halladay | Roy Halladay | Dewon Brazelton | Miguel Batista | 2 | 5 | -3 |
| 2005-04-05 | vs TOR | 2 | L 3-6 | 0-2 | 5 | 9,144 | Scott Kazmir | Gustavo Chacin | Gustavo Chacin | Seth McClung | Miguel Batista | 5 | 11 | -6 |
| 2005-04-06 | vs TOR | 3 | W 8-5 | 1-2 | 5 | 8,764 | Mark Hendrickson | Josh Towers | Danys Baez | Scott Schoeneweis | | 13 | 16 | -3 |
| 2005-04-08 | vs OAK | 4 | W 3-2 | 2-2 | 4 | 10,223 | Rob Bell | Joe Blanton | Danys Baez | Juan Cruz | | 16 | 18 | -2 |
| 2005-04-09 | vs OAK | 5 | W 11-2 | 3-2 | 2 | 13,536 | Hideo Nomo | Barry Zito | Hideo Nomo | Barry Zito | | 27 | 20 | 7 |
| 2005-04-10 | vs OAK | 6 | L 1-6 | 3-3 | 4 | 12,174 | Dewon Brazelton | Rich Harden | Rich Harden | Dewon Brazelton | | 28 | 26 | 2 |
| 2005-04-12 | vs BAL | 7 | L 6-7 | 3-4 | 5 | 10,563 | Scott Kazmir | Daniel Cabrera | Todd Williams | Casey Fossum | B.J. Ryan | 34 | 33 | 1 |
| 2005-04-13 | vs BAL | 8 | L 1-5 | 3-5 | 5 | 9,226 | Mark Hendrickson | Erik Bedard | Steve Kline | Mark Hendrickson | | 35 | 38 | -3 |
| 2005-04-14 | vs BAL | 9 | W 12-7 | 4-5 | 5 | 9,797 | Rob Bell | Sidney Ponson | Rob Bell | Sidney Ponson | | 47 | 45 | 2 |
| 2005-04-15 | @ BOS | 10 | L 0-10 | 4-6 | 5 | 35,023 | Hideo Nomo | David Wells | David Wells | Hideo Nomo | | 47 | 55 | -8 |
| 2005-04-16 | @ BOS | 11 | L 2-6 | 4-7 | 5 | 35,106 | Dewon Brazelton | Matt Clement | Matt Clement | Dewon Brazelton | | 49 | 61 | -12 |
| 2005-04-17 | @ BOS | 12 | L 1-3 | 4-8 | 5 | 35,232 | Scott Kazmir | Tim Wakefield | Tim Wakefield | Scott Kazmir | Keith Foulke | 50 | 64 | -14 |
| 2005-04-18 | @ NYA | 13 | L 8-19 | 4-9 | 5 | 35,282 | Rob Bell | Jaret Wright | Jaret Wright | Rob Bell | | 58 | 83 | -25 |
| 2005-04-19 | @ NYA | 14 | W 6-2 | 5-9 | 5 | 45,802 | Hideo Nomo | Randy Johnson | Hideo Nomo | Randy Johnson | | 64 | 85 | -21 |
| 2005-04-20 | vs TEX | 15 | L 10-12 | 5-10 | 5 | 8,816 | John Webb | Ryan Drese | Ryan Drese | John Webb | Francisco Cordero | 74 | 97 | -23 |
| 2005-04-21 | vs TEX | 16 | W 3-2 | 6-10 | 5 | 8,799 | Dewon Brazelton | Kenny Rogers | Dewon Brazelton | Kenny Rogers | Danys Baez | 77 | 99 | -22 |
| 2005-04-22 | vs BOS | 17 | W 5-4 | 7-10 | 5 | 30,530 | Scott Kazmir | Tim Wakefield | Danys Baez | Alan Embree | | 82 | 103 | -21 |
| 2005-04-23 | vs BOS | 18 | W 6-5 | 8-10 | 4 | 33,220 | Doug Waechter | Curt Schilling | Casey Fossum | Curt Schilling | Lance Carter | 88 | 108 | -20 |
| 2005-04-24 | vs BOS | 19 | L 3-11 | 8-11 | 5 | 30,236 | Hideo Nomo | Bronson Arroyo | Bronson Arroyo | Hideo Nomo | | 91 | 119 | -28 |
| 2005-04-26 | @ TOR | 20 | L 5-7 | 8-12 | 5 | 16,690 | Dewon Brazelton | Ted Lilly | Ted Lilly | Dewon Brazelton | Miguel Batista | 96 | 126 | -30 |
| 2005-04-27 | @ TOR | 21 | L 2-8 | 8-13 | 5 | 19,527 | Scott Kazmir | Gustavo Chacin | Gustavo Chacin | Scott Kazmir | | 98 | 134 | -36 |
| 2005-04-28 | @ TOR | 22 | L 4-7 | 8-14 | 5 | 21,409 | Doug Waechter | Josh Towers | Josh Towers | Doug Waechter | Miguel Batista | 102 | 141 | -39 |
| 2005-04-29 | @ BAL | 23 | L 0-5 | 8-15 | 5 | 24,910 | Hideo Nomo | Erik Bedard | Erik Bedard | Hideo Nomo | | 102 | 146 | -44 |
| 2005-04-30 | @ BAL | 24 | L 5-7 | 8-16 | 5 | 19,920 | Mark Hendrickson | Sidney Ponson | Todd Williams | Travis Harper | B.J. Ryan | 107 | 153 | -46 |
| 2005-05-01 | @ BAL | 25 | L 4-7 | 8-17 | 5 | 30,784 | Dewon Brazelton | Bruce Chen | Bruce Chen | Dewon Brazelton | B.J. Ryan | 111 | 160 | -49 |
| 2005-05-02 | vs NYA | 26 | L 2-6 | 8-18 | 5 | 13,217 | Scott Kazmir | Mike Mussina | Mike Mussina | Scott Kazmir | | 113 | 166 | -53 |
| 2005-05-03 | vs NYA | 27 | W 11-4 | 9-18 | 5 | 14,824 | Doug Waechter | Kevin Brown | Doug Waechter | Kevin Brown | | 124 | 170 | -46 |
| 2005-05-04 | vs NYA | 28 | W 11-8 | 10-18 | 5 | 16,452 | Hideo Nomo | Sean Henn | Casey Fossum | Sean Henn | Danys Baez | 135 | 178 | -43 |
| 2005-05-05 | vs NYA | 29 | W 6-2 | 11-18 | 5 | 16,662 | Mark Hendrickson | Chien-Ming Wang | Mark Hendrickson | Chien-Ming Wang | | 141 | 180 | -39 |
| 2005-05-06 | vs MIN | 30 | L 1-7 | 11-19 | 5 | 8,884 | Dewon Brazelton | Johan Santana | Johan Santana | Dewon Brazelton | | 142 | 187 | -45 |
| 2005-05-07 | vs MIN | 31 | L 1-8 | 11-20 | 5 | 12,675 | Scott Kazmir | Kyle Lohse | Kyle Lohse | Scott Kazmir | | 143 | 195 | -52 |
| 2005-05-08 | vs MIN | 32 | L 6-9 | 11-21 | 5 | 9,519 | Doug Waechter | Joe Mays | Joe Mays | Doug Waechter | Joe Nathan | 149 | 204 | -55 |
| 2005-05-09 | vs CHA | 33 | W 4-2 | 12-21 | 5 | 8,774 | Hideo Nomo | Freddy Garcia | Lance Carter | Freddy Garcia | Danys Baez | 153 | 206 | -53 |
| 2005-05-10 | vs CHA | 34 | W 7-6 | 13-21 | 5 | 9,389 | Mark Hendrickson | Jose Contreras | Jesus Colome | Shingo Takatsu | | 160 | 212 | -52 |
| 2005-05-11 | vs CHA | 35 | L 2-5 | 13-22 | 5 | 9,414 | Dewon Brazelton | Orlando Hernandez | Orlando Hernandez | Dewon Brazelton | Dustin Hermanson | 162 | 217 | -55 |
| 2005-05-12 | @ KCA | 36 | L 5-7 | 13-23 | 5 | 10,807 | Scott Kazmir | Jose Lima | Mike Wood | Lance Carter | | 167 | 224 | -57 |
| 2005-05-13 | @ KCA | 37 | W 3-2 | 14-23 | 5 | 19,547 | Doug Waechter | D.J. Carrasco | Danys Baez | Ambiorix Burgos | | 170 | 226 | -56 |
| 2005-05-14 | @ KCA | 38 | L 5-6 | 14-24 | 5 | 17,151 | Hideo Nomo | Runelvys Hernandez | Runelvys Hernandez | Jesus Colome | Mike Wood | 175 | 232 | -57 |
| 2005-05-15 | @ KCA | 39 | L 3-4 | 14-25 | 5 | 12,000 | Mark Hendrickson | Zack Greinke | Mike MacDougal | Mark Hendrickson | Mike Wood | 178 | 236 | -58 |
| 2005-05-17 | @ DET | 40 | L 3-4 | 14-26 | 5 | 15,955 | Casey Fossum | Jason Johnson | Franklyn German | Travis Harper | | 181 | 240 | -59 |
| 2005-05-18 | @ DET | 41 | L 4-6 | 14-27 | 5 | 17,414 | Doug Waechter | Wil Ledezma | Wil Ledezma | Doug Waechter | Ugueth Urbina | 185 | 246 | -61 |
| 2005-05-19 | @ DET | 42 | W 6-2 | 15-27 | 5 | 20,355 | Scott Kazmir | Mike Maroth | Scott Kazmir | Mike Maroth | Danys Baez | 191 | 248 | -57 |
| 2005-05-20 | @ FLO | 43 | L 6-7 | 15-28 | 5 | 20,284 | Hideo Nomo | Al Leiter | Al Leiter | Hideo Nomo | Todd Jones | 197 | 255 | -58 |
| 2005-05-21 | @ FLO | 44 | L 3-4 | 15-29 | 5 | 25,432 | Mark Hendrickson | A.J. Burnett | Matt Perisho | Jesus Colome | Todd Jones | 200 | 259 | -59 |
| 2005-05-22 | @ FLO | 45 | L 5-8 | 15-30 | 5 | 28,391 | Casey Fossum | Brian Moehler | John Riedling | Casey Fossum | Todd Jones | 205 | 267 | -62 |
| 2005-05-24 | vs OAK | 46 | W 5-4 | 16-30 | 5 | 8,801 | Doug Waechter | Seth Etherton | Travis Harper | Kirk Saarloos | Danys Baez | 210 | 271 | -61 |
| 2005-05-25 | vs OAK | 47 | W 14-6 | 17-30 | 5 | 8,785 | Scott Kazmir | Joe Blanton | Scott Kazmir | Joe Blanton | | 224 | 277 | -53 |
| 2005-05-26 | vs OAK | 48 | W 2-1 | 18-30 | 5 | 8,847 | Hideo Nomo | Dan Haren | Hideo Nomo | Dan Haren | Danys Baez | 226 | 278 | -52 |
| 2005-05-27 | vs SEA | 49 | W 5-4 | 19-30 | 5 | 10,130 | Mark Hendrickson | Gil Meche | Mark Hendrickson | Gil Meche | Danys Baez | 231 | 282 | -51 |
| 2005-05-28 | vs SEA | 50 | L 2-3 | 19-31 | 5 | 13,281 | Casey Fossum | Aaron Sele | Aaron Sele | Casey Fossum | Eddie Guardado | 233 | 285 | -52 |
| 2005-05-29 | vs SEA | 51 | L 9-10 | 19-32 | 5 | 13,851 | Doug Waechter | Joel Pineiro | Ron Villone | Seth McClung | Eddie Guardado | 242 | 295 | -53 |
| 2005-05-30 | @ OAK | 52 | L 4-5 | 19-33 | 5 | 25,921 | Scott Kazmir | Joe Blanton | Huston Street | Travis Harper | | 246 | 300 | -54 |
| 2005-05-31 | @ OAK | 53 | L 1-10 | 19-34 | 5 | 11,702 | Hideo Nomo | Dan Haren | Dan Haren | Hideo Nomo | | 247 | 310 | -63 |
| 2005-06-01 | @ OAK | 54 | L 2-11 | 19-35 | 5 | 16,246 | Mark Hendrickson | Barry Zito | Barry Zito | Mark Hendrickson | | 249 | 321 | -72 |
| 2005-06-03 | @ SEA | 55 | W 6-1 | 20-35 | 5 | 35,344 | Casey Fossum | Aaron Sele | Doug Waechter | Aaron Sele | | 255 | 322 | -67 |
| 2005-06-04 | @ SEA | 56 | L 5-6 | 20-36 | 5 | 32,742 | Scott Kazmir | Joel Pineiro | Julio Mateo | Danys Baez | Eddie Guardado | 260 | 328 | -68 |
| 2005-06-05 | @ SEA | 57 | L 5-6 | 20-37 | 5 | 40,004 | Hideo Nomo | Jamie Moyer | Ron Villone | Chad Orvella | | 265 | 334 | -69 |
| 2005-06-07 | @ CIN | 58 | L 7-9 | 20-38 | 5 | 17,172 | Mark Hendrickson | Ramon Ortiz | Randy Keisler | Travis Harper | David Weathers | 272 | 343 | -71 |
| 2005-06-08 | @ CIN | 59 | L 9-11 | 20-39 | 5 | 32,019 | Doug Waechter | Eric Milton | David Weathers | Danys Baez | | 281 | 354 | -73 |
| 2005-06-09 | @ CIN | 60 | L 5-14 | 20-40 | 5 | 16,381 | Casey Fossum | Luke Hudson | Luke Hudson | Casey Fossum | | 286 | 368 | -82 |
| 2005-06-10 | @ PIT | 61 | L 2-7 | 20-41 | 5 | 27,517 | Hideo Nomo | Mark Redman | Mark Redman | Hideo Nomo | | 288 | 375 | -87 |
| 2005-06-11 | @ PIT | 62 | L 2-18 | 20-42 | 5 | 31,113 | Scott Kazmir | Oliver Perez | Oliver Perez | Scott Kazmir | | 290 | 393 | -103 |
| 2005-06-12 | @ PIT | 63 | W 7-5 | 21-42 | 5 | 23,240 | Mark Hendrickson | Josh Fogg | Franklin Nunez | Brian Meadows | Chad Orvella | 297 | 398 | -101 |
| 2005-06-13 | vs MIL | 64 | W 5-3 | 22-42 | 5 | 8,878 | Doug Waechter | Chris Capuano | Doug Waechter | Chris Capuano | Danys Baez | 302 | 401 | -99 |
| 2005-06-14 | vs MIL | 65 | L 0-4 | 22-43 | 5 | 8,897 | Casey Fossum | Tomo Ohka | Tomo Ohka | Casey Fossum | | 302 | 405 | -103 |
| 2005-06-15 | vs MIL | 66 | W 5-3 | 23-43 | 5 | 8,801 | Hideo Nomo | Victor Santos | Hideo Nomo | Victor Santos | Danys Baez | 307 | 408 | -101 |
| 2005-06-17 | vs SLN | 67 | L 4-6 | 23-44 | 5 | 19,099 | Scott Kazmir | Mark Mulder | Mark Mulder | Travis Harper | Jason Isringhausen | 311 | 414 | -103 |
| 2005-06-18 | vs SLN | 68 | L 2-5 | 23-45 | 5 | 20,416 | Mark Hendrickson | Matt Morris | Matt Morris | Mark Hendrickson | Jason Isringhausen | 313 | 419 | -106 |
| 2005-06-19 | vs SLN | 69 | L 5-8 | 23-46 | 5 | 21,275 | Doug Waechter | Jeff Suppan | Jeff Suppan | Doug Waechter | Jason Isringhausen | 318 | 427 | -109 |
| 2005-06-20 | @ NYA | 70 | W 5-4 | 24-46 | 5 | 43,543 | Casey Fossum | Sean Henn | Casey Fossum | Sean Henn | Danys Baez | 323 | 431 | -108 |
| 2005-06-21 | @ NYA | 71 | L 11-20 | 24-47 | 5 | 40,241 | Hideo Nomo | Randy Johnson | Buddy Groom | Travis Harper | | 334 | 451 | -117 |
| 2005-06-22 | @ NYA | 72 | W 5-3 | 25-47 | 5 | 48,452 | Scott Kazmir | Carl Pavano | Scott Kazmir | Carl Pavano | Danys Baez | 339 | 454 | -115 |
| 2005-06-23 | @ NYA | 73 | W 9-4 | 26-47 | 5 | 45,382 | Mark Hendrickson | Chien-Ming Wang | Mark Hendrickson | Chien-Ming Wang | Danys Baez | 348 | 458 | -110 |
| 2005-06-24 | vs FLO | 74 | L 4-7 | 26-48 | 5 | 10,624 | Doug Waechter | Al Leiter | Guillermo Mota | Doug Waechter | Todd Jones | 352 | 465 | -113 |
| 2005-06-25 | vs FLO | 75 | L 2-6 | 26-49 | 5 | 13,232 | Casey Fossum | Scott Olsen | Scott Olsen | Casey Fossum | | 354 | 471 | -117 |
| 2005-06-26 | vs FLO | 76 | L 0-1 | 26-50 | 5 | 12,233 | Seth McClung | A.J. Burnett | A.J. Burnett | Seth McClung | | 354 | 472 | -118 |
| 2005-06-27 | vs TOR | 77 | W 4-3 | 27-50 | 5 | 8,779 | Hideo Nomo | Pete Walker | Hideo Nomo | Pete Walker | Danys Baez | 358 | 475 | -117 |
| 2005-06-28 | vs TOR | 78 | L 1-3 | 27-51 | 5 | 8,545 | Scott Kazmir | Roy Halladay | Miguel Batista | Doug Waechter | | 359 | 478 | -119 |
| 2005-06-29 | vs TOR | 79 | L 3-12 | 27-52 | 5 | 20,267 | Mark Hendrickson | Josh Towers | Josh Towers | Mark Hendrickson | | 362 | 490 | -128 |
| 2005-07-01 | @ MIN | 80 | L 4-7 | 27-53 | 5 | 23,428 | Casey Fossum | Johan Santana | Jesse Crain | Dewon Brazelton | Joe Nathan | 366 | 497 | -131 |
| 2005-07-02 | @ MIN | 81 | L 1-4 | 27-54 | 5 | 26,393 | Seth McClung | Kyle Lohse | Kyle Lohse | Seth McClung | Joe Nathan | 367 | 501 | -134 |
| 2005-07-03 | @ MIN | 82 | L 2-3 | 27-55 | 5 | 28,757 | Scott Kazmir | Joe Mays | Joe Mays | Scott Kazmir | Joe Nathan | 369 | 504 | -135 |
| 2005-07-04 | @ CHA | 83 | L 8-10 | 27-56 | 5 | 37,351 | Hideo Nomo | Brandon McCarthy | Luis Vizcaino | Hideo Nomo | Dustin Hermanson | 377 | 514 | -137 |
| 2005-07-05 | @ CHA | 84 | L 4-6 | 27-57 | 5 | 21,555 | Mark Hendrickson | Freddy Garcia | Cliff Politte | Lance Carter | Dustin Hermanson | 381 | 520 | -139 |
| 2005-07-06 | @ CHA | 85 | L 2-7 | 27-58 | 5 | 24,773 | Casey Fossum | Jose Contreras | Jose Contreras | Casey Fossum | | 383 | 527 | -144 |
| 2005-07-07 | vs DET | 86 | L 4-6 | 27-59 | 5 | 9,174 | Seth McClung | Sean Douglass | Sean Douglass | Seth McClung | Troy Percival | 387 | 533 | -146 |
| 2005-07-08 | vs DET | 87 | L 3-7 | 27-60 | 5 | 10,582 | Scott Kazmir | Nate Robertson | Franklyn German | Scott Kazmir | | 390 | 540 | -150 |
| 2005-07-09 | vs DET | 88 | W 5-4 | 28-60 | 5 | 9,320 | Hideo Nomo | Jason Johnson | Danys Baez | Troy Percival | | 395 | 544 | -149 |
| 2005-07-10 | vs DET | 89 | L 4-9 | 28-61 | 5 | 15,223 | Mark Hendrickson | Mike Maroth | Mike Maroth | Mark Hendrickson | | 399 | 553 | -154 |
| 2005-07-14 | @ TOR | 90 | W 3-0 | 29-61 | 5 | 20,010 | Casey Fossum | Ted Lilly | Casey Fossum | Ted Lilly | Danys Baez | 402 | 553 | -151 |
| 2005-07-15 | @ TOR | 91 | L 6-11 | 29-62 | 5 | 20,841 | Hideo Nomo | Gustavo Chacin | Gustavo Chacin | Hideo Nomo | | 408 | 564 | -156 |
| 2005-07-16 | @ TOR | 92 | W 6-5 | 30-62 | 5 | 24,801 | Mark Hendrickson | Josh Towers | Mark Hendrickson | Josh Towers | Danys Baez | 414 | 569 | -155 |
| 2005-07-17 | @ TOR | 93 | W 5-4 | 31-62 | 5 | 25,198 | Seth McClung | Pete Walker | Chad Orvella | Miguel Batista | Danys Baez | 419 | 573 | -154 |
| 2005-07-18 | @ BOS | 94 | W 3-1 | 32-62 | 5 | 35,405 | Scott Kazmir | Wade Miller | Scott Kazmir | Wade Miller | Danys Baez | 422 | 574 | -152 |
| 2005-07-19 | @ BOS | 95 | L 2-5 | 32-63 | 5 | 35,428 | Casey Fossum | Bronson Arroyo | Bronson Arroyo | Casey Fossum | Curt Schilling | 424 | 579 | -155 |
| 2005-07-20 | @ BOS | 96 | L 4-9 | 32-64 | 5 | 35,123 | Mark Hendrickson | David Wells | David Wells | Mark Hendrickson | | 428 | 588 | -160 |
| 2005-07-22 | vs BAL | 97 | W 7-5 | 33-64 | 5 | 14,747 | Seth McClung | Bruce Chen | Seth McClung | Bruce Chen | Danys Baez | 435 | 593 | -158 |
| 2005-07-23 | vs BAL | 98 | W 3-2 | 34-64 | 5 | 20,571 | Scott Kazmir | Sidney Ponson | Scott Kazmir | Sidney Ponson | Danys Baez | 438 | 595 | -157 |
| 2005-07-24 | vs BAL | 99 | W 6-2 | 35-64 | 5 | 20,129 | Casey Fossum | Erik Bedard | Casey Fossum | Erik Bedard | | 444 | 597 | -153 |
| 2005-07-25 | vs BOS | 100 | W 4-3 | 36-64 | 5 | 21,550 | Doug Waechter | David Wells | Jesus Colome | Curt Schilling | | 448 | 600 | -152 |
| 2005-07-26 | vs BOS | 101 | L 9-10 | 36-65 | 5 | 24,029 | Mark Hendrickson | Matt Clement | Curt Schilling | Danys Baez | | 457 | 610 | -153 |
| 2005-07-27 | vs BOS | 102 | L 1-4 | 36-66 | 5 | 22,079 | Seth McClung | Tim Wakefield | Tim Wakefield | Seth McClung | Curt Schilling | 458 | 614 | -156 |
| 2005-07-28 | vs KCA | 103 | W 10-5 | 37-66 | 5 | 8,308 | Scott Kazmir | Kyle Snyder | Scott Kazmir | Kyle Snyder | | 468 | 619 | -151 |
| 2005-07-29 | vs KCA | 104 | W 6-3 | 38-66 | 5 | 12,250 | Casey Fossum | D.J. Carrasco | Casey Fossum | D.J. Carrasco | Danys Baez | 474 | 622 | -148 |
| 2005-07-30 | vs KCA | 105 | W 7-3 | 39-66 | 5 | 11,940 | Doug Waechter | Zack Greinke | Doug Waechter | Zack Greinke | | 481 | 625 | -144 |
| 2005-07-31 | vs KCA | 106 | W 6-2 | 40-66 | 5 | 12,119 | Mark Hendrickson | Jose Lima | Mark Hendrickson | Jose Lima | | 487 | 627 | -140 |
| 2005-08-02 | @ TEX | 107 | W 10-8 | 41-66 | 5 | 30,038 | Seth McClung | Chris Young | Seth McClung | Chris Young | Danys Baez | 497 | 635 | -138 |
| 2005-08-03 | @ TEX | 108 | W 8-5 | 42-66 | 5 | 30,513 | Scott Kazmir | Ricardo Rodriguez | Travis Harper | Ricardo Rodriguez | Danys Baez | 505 | 640 | -135 |
| 2005-08-04 | @ TEX | 109 | L 5-13 | 42-67 | 5 | 27,176 | Casey Fossum | Joaquin Benoit | Kevin Gryboski | Chad Orvella | | 510 | 653 | -143 |
| 2005-08-05 | @ ANA | 110 | L 4-5 | 42-68 | 5 | 43,873 | Doug Waechter | Paul Byrd | Scot Shields | Doug Waechter | Francisco Rodriguez | 514 | 658 | -144 |
| 2005-08-06 | @ ANA | 111 | W 6-4 | 43-68 | 5 | 43,909 | Mark Hendrickson | Chris Bootcheck | Mark Hendrickson | Chris Bootcheck | Danys Baez | 520 | 662 | -142 |
| 2005-08-07 | @ ANA | 112 | L 4-10 | 43-69 | 5 | 43,730 | Seth McClung | Bartolo Colon | Bartolo Colon | Seth McClung | | 524 | 672 | -148 |
| 2005-08-09 | @ BAL | 113 | L 2-5 | 43-70 | 5 | 34,870 | Scott Kazmir | Erik Bedard | Erik Bedard | Scott Kazmir | B.J. Ryan | 526 | 677 | -151 |
| 2005-08-10 | @ BAL | 114 | L 5-9 | 43-71 | 5 | 25,556 | Casey Fossum | Rodrigo Lopez | Rodrigo Lopez | Casey Fossum | | 531 | 686 | -155 |
| 2005-08-11 | @ BAL | 115 | L 2-4 | 43-72 | 5 | 27,958 | Doug Waechter | Bruce Chen | Bruce Chen | Doug Waechter | B.J. Ryan | 533 | 690 | -157 |
| 2005-08-12 | @ CLE | 116 | W 8-6 | 44-72 | 5 | 22,597 | Mark Hendrickson | Jake Westbrook | Mark Hendrickson | Jake Westbrook | Danys Baez | 541 | 696 | -155 |
| 2005-08-13 | @ CLE | 117 | W 8-2 | 45-72 | 5 | 34,765 | Seth McClung | Scott Elarton | Seth McClung | Scott Elarton | | 549 | 698 | -149 |
| 2005-08-14 | @ CLE | 118 | W 1-0 | 46-72 | 5 | 25,361 | Scott Kazmir | Cliff Lee | Joe Borowski | Bob Wickman | Danys Baez | 550 | 698 | -148 |
| 2005-08-15 | vs NYA | 119 | L 2-5 | 46-73 | 5 | 19,320 | Casey Fossum | Jaret Wright | Jaret Wright | Casey Fossum | Mariano Rivera | 552 | 703 | -151 |
| 2005-08-16 | vs NYA | 120 | W 4-3 | 47-73 | 5 | 20,678 | Doug Waechter | Randy Johnson | Chad Orvella | Alan Embree | | 556 | 706 | -150 |
| 2005-08-17 | vs NYA | 121 | W 7-6 | 48-73 | 5 | 20,178 | Mark Hendrickson | Al Leiter | Trever Miller | Tanyon Sturtze | Danys Baez | 563 | 712 | -149 |
| 2005-08-19 | vs TEX | 122 | W 2-1 | 49-73 | 5 | 10,188 | Seth McClung | Juan Dominguez | Seth McClung | Juan Dominguez | Danys Baez | 565 | 713 | -148 |
| 2005-08-20 | vs TEX | 123 | W 4-2 | 50-73 | 5 | 19,041 | Scott Kazmir | Joaquin Benoit | Scott Kazmir | Joaquin Benoit | Danys Baez | 569 | 715 | -146 |
| 2005-08-21 | vs TEX | 124 | W 6-3 | 51-73 | 5 | 13,974 | Casey Fossum | Kenny Rogers | Casey Fossum | Kenny Rogers | Danys Baez | 575 | 718 | -143 |
| 2005-08-22 | vs CLE | 125 | L 4-11 | 51-74 | 5 | 8,564 | Doug Waechter | Kevin Millwood | Kevin Millwood | Trever Miller | | 579 | 729 | -150 |
| 2005-08-23 | vs CLE | 126 | L 4-5 | 51-75 | 5 | 8,648 | Mark Hendrickson | Jake Westbrook | Jake Westbrook | Trever Miller | Bob Wickman | 583 | 734 | -151 |
| 2005-08-24 | vs CLE | 127 | W 13-3 | 52-75 | 5 | 11,261 | Seth McClung | Scott Elarton | Seth McClung | Scott Elarton | | 596 | 737 | -141 |
| 2005-08-25 | vs CLE | 128 | L 4-12 | 52-76 | 5 | 9,172 | Scott Kazmir | Cliff Lee | Cliff Lee | Scott Kazmir | | 600 | 749 | -149 |
| 2005-08-26 | vs ANA | 129 | W 12-8 | 53-76 | 5 | 13,039 | Casey Fossum | Ervin Santana | Casey Fossum | Ervin Santana | | 612 | 757 | -145 |
| 2005-08-27 | vs ANA | 130 | W 6-3 | 54-76 | 5 | 12,445 | Doug Waechter | Paul Byrd | Doug Waechter | Paul Byrd | Danys Baez | 618 | 760 | -142 |
| 2005-08-28 | vs ANA | 131 | W 2-1 | 55-76 | 5 | 13,703 | Mark Hendrickson | Jarrod Washburn | Mark Hendrickson | Jarrod Washburn | Danys Baez | 620 | 761 | -141 |
| 2005-08-29 | @ BOS | 132 | L 6-10 | 55-77 | 5 | 35,007 | Seth McClung | Matt Clement | Matt Clement | Seth McClung | | 626 | 771 | -145 |
| 2005-08-30 | @ BOS | 133 | L 6-7 | 55-78 | 5 | 35,101 | Scott Kazmir | Curt Schilling | Mike Timlin | Joe Borowski | | 632 | 778 | -146 |
| 2005-08-31 | @ BOS | 134 | L 6-7 | 55-79 | 5 | 35,253 | Casey Fossum | Tim Wakefield | Tim Wakefield | Casey Fossum | Mike Timlin | 638 | 785 | -147 |
| 2005-09-01 | @ BOS | 135 | L 4-7 | 55-80 | 5 | 35,337 | Doug Waechter | Bronson Arroyo | Bronson Arroyo | Doug Waechter | Mike Timlin | 642 | 792 | -150 |
| 2005-09-02 | @ TOR | 136 | L 3-4 | 55-81 | 5 | 15,108 | Mark Hendrickson | Scott Downs | Scott Schoeneweis | Joe Borowski | Miguel Batista | 645 | 796 | -151 |
| 2005-09-03 | @ TOR | 137 | W 3-2 | 56-81 | 5 | 18,841 | Seth McClung | Josh Towers | Seth McClung | Miguel Batista | Danys Baez | 648 | 798 | -150 |
| 2005-09-04 | @ TOR | 138 | W 1-0 | 57-81 | 5 | 20,679 | Scott Kazmir | David Bush | Scott Kazmir | David Bush | Danys Baez | 649 | 798 | -149 |
| 2005-09-06 | @ NYA | 139 | W 4-3 | 58-81 | 5 | 48,820 | Casey Fossum | Randy Johnson | Chad Orvella | Mariano Rivera | Danys Baez | 653 | 801 | -148 |
| 2005-09-07 | @ NYA | 140 | L 4-5 | 58-82 | 5 | 52,928 | Doug Waechter | Jaret Wright | Tanyon Sturtze | Joe Borowski | Mariano Rivera | 657 | 806 | -149 |
| 2005-09-08 | @ NYA | 141 | W 7-4 | 59-82 | 5 | 49,673 | Mark Hendrickson | Chien-Ming Wang | Mark Hendrickson | Chien-Ming Wang | Danys Baez | 664 | 810 | -146 |
| 2005-09-09 | vs TOR | 142 | L 2-7 | 59-83 | 5 | 10,092 | Seth McClung | Josh Towers | Josh Towers | Seth McClung | | 666 | 817 | -151 |
| 2005-09-10 | vs TOR | 143 | L 2-3 | 59-84 | 5 | 10,984 | Scott Kazmir | David Bush | David Bush | Danys Baez | Miguel Batista | 668 | 820 | -152 |
| 2005-09-11 | vs TOR | 144 | W 6-5 | 60-84 | 5 | 10,590 | Casey Fossum | Gustavo Chacin | Travis Harper | Scott Schoeneweis | | 674 | 825 | -151 |
| 2005-09-13 | vs NYA | 145 | L 3-17 | 60-85 | 5 | 14,048 | Doug Waechter | Jaret Wright | Jaret Wright | Doug Waechter | | 677 | 842 | -165 |
| 2005-09-14 | vs NYA | 146 | L 5-6 | 60-86 | 5 | 14,396 | Mark Hendrickson | Chien-Ming Wang | Chien-Ming Wang | Chad Orvella | Mariano Rivera | 682 | 848 | -166 |
| 2005-09-15 | vs NYA | 147 | L 5-9 | 60-87 | 5 | 18,391 | Seth McClung | Aaron Small | Aaron Small | Seth McClung | Mariano Rivera | 687 | 857 | -170 |
| 2005-09-16 | @ BAL | 148 | W 6-1 | 61-87 | 5 | 19,972 | Scott Kazmir | Rodrigo Lopez | Scott Kazmir | Rodrigo Lopez | Danys Baez | 693 | 858 | -165 |
| 2005-09-17 | @ BAL | 149 | L 1-2 | 61-88 | 5 | 31,400 | Casey Fossum | Bruce Chen | Todd Williams | Joe Borowski | B.J. Ryan | 694 | 860 | -166 |
| 2005-09-18 | @ BAL | 150 | W 6-5 | 62-88 | 5 | 25,980 | Doug Waechter | Daniel Cabrera | Travis Harper | Todd Williams | Danys Baez | 700 | 865 | -165 |
| 2005-09-19 | vs BOS | 151 | W 8-7 | 63-88 | 5 | 16,124 | Mark Hendrickson | David Wells | Mark Hendrickson | Chad Harville | Danys Baez | 708 | 872 | -164 |
| 2005-09-20 | vs BOS | 152 | L 2-15 | 63-89 | 5 | 18,723 | Seth McClung | Curt Schilling | Curt Schilling | Seth McClung | | 710 | 887 | -177 |
| 2005-09-21 | vs BOS | 153 | W 7-4 | 64-89 | 5 | 20,002 | Scott Kazmir | Tim Wakefield | Trever Miller | Mike Timlin | Danys Baez | 717 | 891 | -174 |
| 2005-09-23 | @ ANA | 154 | L 5-7 | 64-90 | 5 | 42,421 | Casey Fossum | Paul Byrd | Scot Shields | Joe Borowski | Francisco Rodriguez | 722 | 898 | -176 |
| 2005-09-24 | @ ANA | 155 | L 3-7 | 64-91 | 5 | 42,344 | Doug Waechter | Jarrod Washburn | Jarrod Washburn | Doug Waechter | | 725 | 905 | -180 |
| 2005-09-25 | @ ANA | 156 | W 8-4 | 65-91 | 5 | 41,733 | Mark Hendrickson | Bartolo Colon | Mark Hendrickson | Bartolo Colon | | 733 | 909 | -176 |
| 2005-09-27 | @ CLE | 157 | W 5-4 | 66-91 | 5 | 23,795 | Scott Kazmir | Scott Elarton | Scott Kazmir | Scott Elarton | Danys Baez | 738 | 913 | -175 |
| 2005-09-28 | @ CLE | 158 | W 1-0 | 67-91 | 5 | 24,356 | Seth McClung | Cliff Lee | Seth McClung | Cliff Lee | Danys Baez | 739 | 913 | -174 |
| 2005-09-29 | @ CLE | 159 | L 0-6 | 67-92 | 5 | 25,870 | Casey Fossum | CC Sabathia | CC Sabathia | Casey Fossum | | 739 | 919 | -180 |
| 2005-09-30 | vs BAL | 160 | L 6-7 | 67-93 | 5 | 15,805 | Doug Waechter | John Maine | Eric DuBose | Doug Waechter | B.J. Ryan | 745 | 926 | -181 |
| 2005-10-01 | vs BAL | 161 | L 3-4 | 67-94 | 5 | 17,481 | Mark Hendrickson | Rodrigo Lopez | Rodrigo Lopez | Mark Hendrickson | B.J. Ryan | 748 | 930 | -182 |
| 2005-10-02 | vs BAL | 162 | L 2-6 | 67-95 | 5 | 17,450 | Tim Corcoran | Bruce Chen | Bruce Chen | Jesus Colome | | 750 | 936 | -186 |