| 2005-04-05 | @ HOU | 1 | W 7-3 | 1-0 | 3 | 43,567 | Chris Carpenter | Roy Oswalt | Chris Carpenter | Roy Oswalt | Jason Isringhausen | 7 | 3 | 4 |
| 2005-04-06 | @ HOU | 2 | L 1-4 | 1-1 | 4 | 28,496 | Jason Marquis | Andy Pettitte | Chad Qualls | Julian Tavarez | Brad Lidge | 8 | 7 | 1 |
| 2005-04-08 | vs PHI | 3 | W 6-5 | 2-1 | 4 | 50,074 | Mark Mulder | Cory Lidle | Alberto Reyes | Ryan Madson | Jason Isringhausen | 14 | 12 | 2 |
| 2005-04-09 | vs PHI | 4 | L 4-10 | 2-2 | 4 | 39,242 | Jeff Suppan | Gavin Floyd | Gavin Floyd | Jeff Suppan | | 18 | 22 | -4 |
| 2005-04-10 | vs PHI | 5 | L 4-13 | 2-3 | 5 | 37,971 | Chris Carpenter | Jon Lieber | Jon Lieber | Chris Carpenter | | 22 | 35 | -13 |
| 2005-04-12 | vs CIN | 6 | W 5-1 | 3-3 | 3 | 33,617 | Jason Marquis | Aaron Harang | Jason Marquis | Aaron Harang | | 27 | 36 | -9 |
| 2005-04-13 | vs CIN | 7 | L 5-6 | 3-4 | 5 | 28,772 | Mark Mulder | Matt Belisle | Matt Belisle | Mark Mulder | Danny Graves | 32 | 42 | -10 |
| 2005-04-15 | @ MIL | 8 | W 3-0 | 4-4 | 3 | 22,676 | Jeff Suppan | Ben Sheets | Jeff Suppan | Ben Sheets | Jason Isringhausen | 35 | 42 | -7 |
| 2005-04-16 | @ MIL | 9 | W 5-3 | 5-4 | 1 | 30,732 | Chris Carpenter | Doug Davis | Chris Carpenter | Doug Davis | Jason Isringhausen | 40 | 45 | -5 |
| 2005-04-17 | @ MIL | 10 | W 3-2 | 6-4 | 1 | 21,144 | Jason Marquis | Victor Santos | Jason Marquis | Mike Adams | Jason Isringhausen | 43 | 47 | -4 |
| 2005-04-18 | @ PIT | 11 | W 11-1 | 7-4 | 1 | 11,220 | Mark Mulder | David Williams | Mark Mulder | David Williams | | 54 | 48 | 6 |
| 2005-04-19 | @ PIT | 12 | W 7-1 | 8-4 | 1 | 12,285 | Matt Morris | Josh Fogg | Matt Morris | Josh Fogg | | 61 | 49 | 12 |
| 2005-04-20 | vs CHN | 13 | L 1-3 | 8-5 | 1 | 44,855 | Jeff Suppan | Carlos Zambrano | Carlos Zambrano | Jeff Suppan | LaTroy Hawkins | 62 | 52 | 10 |
| 2005-04-21 | vs CHN | 14 | W 4-0 | 9-5 | 1 | 46,119 | Chris Carpenter | Ryan Dempster | Chris Carpenter | Ryan Dempster | | 66 | 52 | 14 |
| 2005-04-22 | vs HOU | 15 | W 8-7 | 10-5 | 1 | 44,805 | Jason Marquis | Brandon Duckworth | Jason Marquis | Brandon Duckworth | Jason Isringhausen | 74 | 59 | 15 |
| 2005-04-23 | vs HOU | 16 | W 1-0 | 11-5 | 1 | 40,058 | Mark Mulder | Roger Clemens | Mark Mulder | Chad Qualls | | 75 | 59 | 16 |
| 2005-04-24 | vs HOU | 17 | W 8-5 | 12-5 | 1 | 39,020 | Matt Morris | Brandon Backe | Matt Morris | Brandon Backe | Jason Isringhausen | 83 | 64 | 19 |
| 2005-04-26 | vs MIL | 18 | W 5-3 | 13-5 | 1 | 28,787 | Jeff Suppan | Doug Davis | Jeff Suppan | Doug Davis | Randy Flores | 88 | 67 | 21 |
| 2005-04-27 | vs MIL | 19 | W 6-3 | 14-5 | 1 | 38,343 | Chris Carpenter | Victor Santos | Chris Carpenter | Victor Santos | Julian Tavarez | 94 | 70 | 24 |
| 2005-04-28 | vs MIL | 20 | L 3-4 | 14-6 | 1 | 26,026 | Jason Marquis | Chris Capuano | Chris Capuano | Jason Marquis | Derrick Turnbow | 97 | 74 | 23 |
| 2005-04-29 | @ ATL | 21 | W 6-5 | 15-6 | 1 | 33,833 | Mark Mulder | Tim Hudson | Mark Mulder | Tim Hudson | Alberto Reyes | 103 | 79 | 24 |
| 2005-04-30 | @ ATL | 22 | L 2-3 | 15-7 | 1 | 35,789 | Matt Morris | John Thomson | Danny Kolb | Jimmy Journell | | 105 | 82 | 23 |
| 2005-05-01 | @ ATL | 23 | L 1-2 | 15-8 | 1 | 34,304 | Jeff Suppan | John Smoltz | John Smoltz | Jeff Suppan | Danny Kolb | 106 | 84 | 22 |
| 2005-05-02 | @ CIN | 24 | W 10-9 | 16-8 | 1 | 15,961 | Chris Carpenter | Eric Milton | Randy Flores | Danny Graves | Julian Tavarez | 116 | 93 | 23 |
| 2005-05-03 | @ CIN | 25 | W 4-2 | 17-8 | 1 | 16,512 | Jason Marquis | Aaron Harang | Jason Marquis | Aaron Harang | Alberto Reyes | 120 | 95 | 25 |
| 2005-05-04 | @ CIN | 26 | W 7-3 | 18-8 | 1 | 17,241 | Mark Mulder | Brandon Claussen | Mark Mulder | Brandon Claussen | | 127 | 98 | 29 |
| 2005-05-05 | vs SDN | 27 | L 3-8 | 18-9 | 1 | 30,507 | Matt Morris | Brian Lawrence | Chris Hammond | Ray King | | 130 | 106 | 24 |
| 2005-05-06 | vs SDN | 28 | L 5-6 | 18-10 | 1 | 47,160 | Jeff Suppan | Darrell May | Randy Williams | Randy Flores | Trevor Hoffman | 135 | 112 | 23 |
| 2005-05-07 | vs SDN | 29 | L 4-5 | 18-11 | 1 | 45,950 | Chris Carpenter | Adam Eaton | Adam Eaton | Chris Carpenter | Trevor Hoffman | 139 | 117 | 22 |
| 2005-05-08 | vs SDN | 30 | W 15-5 | 19-11 | 1 | 46,444 | Jason Marquis | Tim Redding | Jason Marquis | Tim Redding | Brad Thompson | 154 | 122 | 32 |
| 2005-05-09 | vs LAN | 31 | W 4-2 | 20-11 | 1 | 37,194 | Mark Mulder | Odalis Perez | Mark Mulder | Odalis Perez | Alberto Reyes | 158 | 124 | 34 |
| 2005-05-10 | vs LAN | 32 | L 8-9 | 20-12 | 1 | 38,984 | Matt Morris | Scott Erickson | Wilson Alvarez | Kevin Jarvis | Yhency Brazoban | 166 | 133 | 33 |
| 2005-05-11 | vs LAN | 33 | W 9-3 | 21-12 | 1 | 35,671 | Jeff Suppan | Brad Penny | Jeff Suppan | Brad Penny | | 175 | 136 | 39 |
| 2005-05-12 | vs LAN | 34 | W 10-3 | 22-12 | 1 | 45,656 | Chris Carpenter | Derek Lowe | Chris Carpenter | Derek Lowe | | 185 | 139 | 46 |
| 2005-05-13 | @ NYN | 35 | L 0-2 | 22-13 | 1 | 43,495 | Jason Marquis | Tom Glavine | Tom Glavine | Jason Marquis | Braden Looper | 185 | 141 | 44 |
| 2005-05-14 | @ NYN | 36 | W 7-6 | 23-13 | 1 | 40,921 | Mark Mulder | Pedro Martinez | Julian Tavarez | Roberto Hernandez | Jason Isringhausen | 192 | 147 | 45 |
| 2005-05-15 | @ NYN | 37 | W 4-2 | 24-13 | 1 | 32,949 | Matt Morris | Aaron Heilman | Matt Morris | Aaron Heilman | Jason Isringhausen | 196 | 149 | 47 |
| 2005-05-17 | @ PHI | 38 | L 5-7 | 24-14 | 1 | 32,103 | Jeff Suppan | Cory Lidle | Cory Lidle | Jeff Suppan | Billy Wagner | 201 | 156 | 45 |
| 2005-05-18 | @ PHI | 39 | W 8-4 | 25-14 | 1 | 29,130 | Chris Carpenter | Jon Lieber | Chris Carpenter | Jon Lieber | | 209 | 160 | 49 |
| 2005-05-19 | @ PHI | 40 | L 4-7 | 25-15 | 1 | 38,229 | Jason Marquis | Brett Myers | Brett Myers | Jason Marquis | | 213 | 167 | 46 |
| 2005-05-20 | @ KCA | 41 | W 7-6 | 26-15 | 1 | 31,513 | Mark Mulder | Zack Greinke | Mark Mulder | Zack Greinke | Jason Isringhausen | 220 | 173 | 47 |
| 2005-05-21 | @ KCA | 42 | W 6-5 | 27-15 | 1 | 39,781 | Matt Morris | Jose Lima | Matt Morris | Jaime Cerda | Jason Isringhausen | 226 | 178 | 48 |
| 2005-05-22 | @ KCA | 43 | L 2-9 | 27-16 | 1 | 29,269 | Jeff Suppan | Ryan Jensen | Ryan Jensen | Jeff Suppan | | 228 | 187 | 41 |
| 2005-05-23 | vs PIT | 44 | W 4-2 | 28-16 | 1 | 33,073 | Chris Carpenter | David Williams | Chris Carpenter | David Williams | Jason Isringhausen | 232 | 189 | 43 |
| 2005-05-24 | vs PIT | 45 | W 2-1 | 29-16 | 1 | 36,285 | Jason Marquis | Kip Wells | Alberto Reyes | Jose Mesa | | 234 | 190 | 44 |
| 2005-05-25 | vs PIT | 46 | W 11-5 | 30-16 | 1 | 34,895 | Mark Mulder | Mark Redman | Mark Mulder | Mark Redman | | 245 | 195 | 50 |
| 2005-05-27 | vs WAS | 47 | W 6-3 | 31-16 | 1 | 47,383 | Matt Morris | Tony Armas | Matt Morris | Tony Armas | Jason Isringhausen | 251 | 198 | 53 |
| 2005-05-28 | vs WAS | 48 | W 3-1 | 32-16 | 1 | 49,123 | Jeff Suppan | Esteban Loaiza | Jeff Suppan | Esteban Loaiza | Jason Isringhausen | 254 | 199 | 55 |
| 2005-05-29 | vs WAS | 49 | L 2-3 | 32-17 | 1 | 47,012 | Chris Carpenter | Livan Hernandez | Livan Hernandez | Chris Carpenter | Chad Cordero | 256 | 202 | 54 |
| 2005-05-30 | @ COL | 50 | W 5-4 | 33-17 | 1 | 34,239 | Jason Marquis | Jamey Wright | Jason Marquis | Jay Witasick | Jason Isringhausen | 261 | 206 | 55 |
| 2005-05-31 | @ COL | 51 | L 1-2 | 33-18 | 1 | 23,519 | Mark Mulder | Jason Jennings | Jason Jennings | Mark Mulder | Brian Fuentes | 262 | 208 | 54 |
| 2005-06-01 | @ COL | 52 | W 8-6 | 34-18 | 1 | 22,266 | Matt Morris | Joe Kennedy | Matt Morris | Blaine Neal | Jason Isringhausen | 270 | 214 | 56 |
| 2005-06-02 | @ COL | 53 | L 7-8 | 34-19 | 1 | 21,381 | Jeff Suppan | Shawn Chacon | Brian Fuentes | Jason Isringhausen | | 277 | 222 | 55 |
| 2005-06-03 | @ HOU | 54 | W 2-0 | 35-19 | 1 | 34,092 | Chris Carpenter | Andy Pettitte | Chris Carpenter | Andy Pettitte | Julian Tavarez | 279 | 222 | 57 |
| 2005-06-04 | @ HOU | 55 | W 11-9 | 36-19 | 1 | 39,288 | Jason Marquis | Wandy Rodriguez | Jason Marquis | Wandy Rodriguez | Jason Isringhausen | 290 | 231 | 59 |
| 2005-06-05 | @ HOU | 56 | L 4-6 | 36-20 | 1 | 34,009 | Mark Mulder | Roger Clemens | Roger Clemens | Mark Mulder | Brad Lidge | 294 | 237 | 57 |
| 2005-06-06 | vs BOS | 57 | W 7-1 | 37-20 | 1 | 50,270 | Matt Morris | Tim Wakefield | Matt Morris | Tim Wakefield | | 301 | 238 | 63 |
| 2005-06-07 | vs BOS | 58 | W 9-2 | 38-20 | 1 | 47,496 | Jeff Suppan | Matt Clement | Jeff Suppan | Matt Clement | | 310 | 240 | 70 |
| 2005-06-08 | vs BOS | 59 | L 0-4 | 38-21 | 1 | 46,928 | Chris Carpenter | David Wells | David Wells | Chris Carpenter | | 310 | 244 | 66 |
| 2005-06-10 | vs NYA | 60 | W 8-1 | 39-21 | 1 | 50,250 | Jason Marquis | Chien-Ming Wang | Jason Marquis | Chien-Ming Wang | | 318 | 245 | 73 |
| 2005-06-11 | vs NYA | 61 | L 0-5 | 39-22 | 1 | 50,177 | Mark Mulder | Randy Johnson | Randy Johnson | Mark Mulder | Mariano Rivera | 318 | 250 | 68 |
| 2005-06-12 | vs NYA | 62 | W 5-3 | 40-22 | 1 | 50,372 | Matt Morris | Carl Pavano | Ray King | Tanyon Sturtze | Jason Isringhausen | 323 | 253 | 70 |
| 2005-06-13 | @ TOR | 63 | L 1-4 | 40-23 | 1 | 20,032 | Jeff Suppan | Roy Halladay | Roy Halladay | Jeff Suppan | | 324 | 257 | 67 |
| 2005-06-14 | @ TOR | 64 | W 7-0 | 41-23 | 1 | 37,536 | Chris Carpenter | Chad Gaudin | Chris Carpenter | Chad Gaudin | | 331 | 257 | 74 |
| 2005-06-15 | @ TOR | 65 | L 2-5 | 41-24 | 1 | 22,905 | Jason Marquis | Ted Lilly | Ted Lilly | Jason Marquis | Miguel Batista | 333 | 262 | 71 |
| 2005-06-17 | @ TBA | 66 | W 6-4 | 42-24 | 1 | 19,099 | Mark Mulder | Scott Kazmir | Mark Mulder | Travis Harper | Jason Isringhausen | 339 | 266 | 73 |
| 2005-06-18 | @ TBA | 67 | W 5-2 | 43-24 | 1 | 20,416 | Matt Morris | Mark Hendrickson | Matt Morris | Mark Hendrickson | Jason Isringhausen | 344 | 268 | 76 |
| 2005-06-19 | @ TBA | 68 | W 8-5 | 44-24 | 1 | 21,275 | Jeff Suppan | Doug Waechter | Jeff Suppan | Doug Waechter | Jason Isringhausen | 352 | 273 | 79 |
| 2005-06-20 | @ CIN | 69 | W 6-1 | 45-24 | 1 | 22,035 | Chris Carpenter | Aaron Harang | Chris Carpenter | Aaron Harang | | 358 | 274 | 84 |
| 2005-06-21 | @ CIN | 70 | L 4-11 | 45-25 | 1 | 22,268 | Jason Marquis | Brandon Claussen | Brandon Claussen | Jason Marquis | | 362 | 285 | 77 |
| 2005-06-22 | @ CIN | 71 | L 6-7 | 45-26 | 1 | 31,566 | Mark Mulder | Ramon Ortiz | Ramon Ortiz | Mark Mulder | Kent Mercker | 368 | 292 | 76 |
| 2005-06-23 | vs PIT | 72 | L 7-11 | 45-27 | 1 | 43,590 | Matt Morris | David Williams | David Williams | Matt Morris | Rick White | 375 | 303 | 72 |
| 2005-06-24 | vs PIT | 73 | W 8-1 | 46-27 | 1 | 48,184 | Jeff Suppan | Kip Wells | Jeff Suppan | Kip Wells | | 383 | 304 | 79 |
| 2005-06-25 | vs PIT | 74 | W 8-0 | 47-27 | 1 | 48,413 | Chris Carpenter | Mark Redman | Chris Carpenter | Mark Redman | | 391 | 304 | 87 |
| 2005-06-26 | vs PIT | 75 | L 4-5 | 47-28 | 1 | 45,050 | Jason Marquis | Oliver Perez | John Grabow | Alberto Reyes | Jose Mesa | 395 | 309 | 86 |
| 2005-06-28 | vs CIN | 76 | W 2-1 | 48-28 | 1 | 38,640 | Mark Mulder | Brandon Claussen | Mark Mulder | Brandon Claussen | Jason Isringhausen | 397 | 310 | 87 |
| 2005-06-29 | vs CIN | 77 | W 11-3 | 49-28 | 1 | 39,298 | Matt Morris | Ramon Ortiz | Matt Morris | Ramon Ortiz | | 408 | 313 | 95 |
| 2005-06-30 | vs COL | 78 | L 0-7 | 49-29 | 1 | 44,036 | Jeff Suppan | Jeff Francis | Jeff Francis | Jeff Suppan | | 408 | 320 | 88 |
| 2005-07-01 | vs COL | 79 | W 6-0 | 50-29 | 1 | 40,128 | Chris Carpenter | Joe Kennedy | Chris Carpenter | Joe Kennedy | | 414 | 320 | 94 |
| 2005-07-02 | vs COL | 80 | L 1-3 | 50-30 | 1 | 47,913 | Jason Marquis | Jamey Wright | Jamey Wright | Jason Marquis | Brian Fuentes | 415 | 323 | 92 |
| 2005-07-03 | vs COL | 81 | W 5-4 | 51-30 | 1 | 47,811 | Mark Mulder | Jason Jennings | Ray King | Jay Witasick | | 420 | 327 | 93 |
| 2005-07-04 | @ ARI | 82 | W 10-3 | 52-30 | 1 | 31,197 | Matt Morris | Brandon Webb | Matt Morris | Brandon Webb | | 430 | 330 | 100 |
| 2005-07-05 | @ ARI | 83 | W 7-1 | 53-30 | 1 | 23,590 | Jeff Suppan | Shawn Estes | Jeff Suppan | Shawn Estes | | 437 | 331 | 106 |
| 2005-07-06 | @ ARI | 84 | W 2-1 | 54-30 | 1 | 21,076 | Chris Carpenter | Javier Vazquez | Chris Carpenter | Javier Vazquez | Jason Isringhausen | 439 | 332 | 107 |
| 2005-07-07 | @ ARI | 85 | L 1-2 | 54-31 | 1 | 21,959 | Jason Marquis | Claudio Vargas | Lance Cormier | Ray King | | 440 | 334 | 106 |
| 2005-07-08 | @ SFN | 86 | W 3-1 | 55-31 | 1 | 41,405 | Mark Mulder | Jason Schmidt | Mark Mulder | Jason Schmidt | Jason Isringhausen | 443 | 335 | 108 |
| 2005-07-09 | @ SFN | 87 | L 0-2 | 55-32 | 1 | 42,423 | Matt Morris | Brad Hennessey | Brad Hennessey | Matt Morris | Tyler Walker | 443 | 337 | 106 |
| 2005-07-10 | @ SFN | 88 | W 4-3 | 56-32 | 1 | 41,925 | Jeff Suppan | Noah Lowry | Jeff Suppan | Noah Lowry | Jason Isringhausen | 447 | 340 | 107 |
| 2005-07-15 | vs HOU | 89 | W 4-3 | 57-32 | 1 | 48,420 | Mark Mulder | Andy Pettitte | Brad Thompson | Chad Harville | | 451 | 343 | 108 |
| 2005-07-16 | vs HOU | 90 | W 4-2 | 58-32 | 1 | 48,034 | Jason Marquis | Roy Oswalt | Jason Marquis | Roy Oswalt | Jason Isringhausen | 455 | 345 | 110 |
| 2005-07-17 | vs HOU | 91 | W 3-0 | 59-32 | 1 | 46,584 | Chris Carpenter | Roger Clemens | Chris Carpenter | Roger Clemens | | 458 | 345 | 113 |
| 2005-07-18 | vs MIL | 92 | W 11-4 | 60-32 | 1 | 41,827 | Matt Morris | Victor Santos | Matt Morris | Victor Santos | | 469 | 349 | 120 |
| 2005-07-19 | vs MIL | 93 | L 4-5 | 60-33 | 1 | 44,270 | Jeff Suppan | Doug Davis | Matt Wise | Julian Tavarez | Derrick Turnbow | 473 | 354 | 119 |
| 2005-07-20 | vs MIL | 94 | W 4-2 | 61-33 | 1 | 40,904 | Mark Mulder | Ben Sheets | Mark Mulder | Ben Sheets | Jason Isringhausen | 477 | 356 | 121 |
| 2005-07-21 | vs MIL | 95 | L 7-12 | 61-34 | 1 | 44,002 | Jason Marquis | Chris Capuano | Chris Capuano | Jason Marquis | | 484 | 368 | 116 |
| 2005-07-22 | vs CHN | 96 | W 2-1 | 62-34 | 1 | 49,840 | Chris Carpenter | Carlos Zambrano | Alberto Reyes | Sergio Mitre | | 486 | 369 | 117 |
| 2005-07-23 | vs CHN | 97 | L 5-6 | 62-35 | 1 | 49,942 | Matt Morris | Jerome Williams | Jerome Williams | Matt Morris | Ryan Dempster | 491 | 375 | 116 |
| 2005-07-24 | vs CHN | 98 | L 4-8 | 62-36 | 1 | 49,762 | Jeff Suppan | Mark Prior | Ryan Dempster | Alberto Reyes | | 495 | 383 | 112 |
| 2005-07-26 | @ SDN | 99 | W 4-2 | 63-36 | 1 | 36,659 | Mark Mulder | Woody Williams | Mark Mulder | Woody Williams | Jason Isringhausen | 499 | 385 | 114 |
| 2005-07-27 | @ SDN | 100 | L 1-2 | 63-37 | 1 | 37,592 | Jason Marquis | Jake Peavy | Trevor Hoffman | Jason Marquis | | 500 | 387 | 113 |
| 2005-07-28 | @ SDN | 101 | W 11-3 | 64-37 | 1 | 38,760 | Chris Carpenter | Tim Stauffer | Chris Carpenter | Tim Stauffer | | 511 | 390 | 121 |
| 2005-07-29 | @ LAN | 102 | L 5-7 | 64-38 | 1 | 53,783 | Matt Morris | Brad Penny | Duaner Sanchez | Matt Morris | Yhency Brazoban | 516 | 397 | 119 |
| 2005-07-30 | @ LAN | 103 | W 9-4 | 65-38 | 1 | 47,805 | Jeff Suppan | Derek Lowe | Jeff Suppan | Derek Lowe | | 525 | 401 | 124 |
| 2005-07-31 | @ LAN | 104 | W 7-5 | 66-38 | 1 | 44,543 | Mark Mulder | Odalis Perez | Cal Eldred | Wilson Alvarez | Jason Isringhausen | 532 | 406 | 126 |
| 2005-08-01 | vs FLO | 105 | L 5-6 | 66-39 | 1 | 43,403 | Jason Marquis | Ismael Valdez | Ismael Valdez | Jason Marquis | Todd Jones | 537 | 412 | 125 |
| 2005-08-02 | vs FLO | 106 | W 3-1 | 67-39 | 1 | 43,557 | Chris Carpenter | Dontrelle Willis | Chris Carpenter | Dontrelle Willis | | 540 | 413 | 127 |
| 2005-08-03 | vs FLO | 107 | W 9-6 | 68-39 | 1 | 43,111 | Matt Morris | Josh Beckett | Matt Morris | Ron Villone | | 549 | 419 | 130 |
| 2005-08-04 | vs FLO | 108 | L 3-4 | 68-40 | 1 | 44,201 | Jeff Suppan | A.J. Burnett | A.J. Burnett | Jeff Suppan | Todd Jones | 552 | 423 | 129 |
| 2005-08-05 | vs ATL | 109 | W 11-3 | 69-40 | 1 | 47,838 | Mark Mulder | John Smoltz | Mark Mulder | John Smoltz | | 563 | 426 | 137 |
| 2005-08-06 | vs ATL | 110 | L 1-8 | 69-41 | 1 | 48,565 | Jason Marquis | Tim Hudson | Tim Hudson | Jason Marquis | | 564 | 434 | 130 |
| 2005-08-07 | vs ATL | 111 | W 5-3 | 70-41 | 1 | 47,714 | Chris Carpenter | Jorge Sosa | Ray King | Chris Reitsma | | 569 | 437 | 132 |
| 2005-08-08 | @ MIL | 112 | W 8-4 | 71-41 | 1 | 30,260 | Matt Morris | Victor Santos | Randy Flores | Matt Wise | | 577 | 441 | 136 |
| 2005-08-09 | @ MIL | 113 | W 5-2 | 72-41 | 1 | 28,556 | Anthony Reyes | Doug Davis | Anthony Reyes | Doug Davis | Jason Isringhausen | 582 | 443 | 139 |
| 2005-08-10 | @ MIL | 114 | W 3-0 | 73-41 | 1 | 37,650 | Jeff Suppan | Ben Sheets | Jeff Suppan | Ben Sheets | Jason Isringhausen | 585 | 443 | 142 |
| 2005-08-11 | @ CHN | 115 | L 4-11 | 73-42 | 1 | 38,170 | Mark Mulder | Greg Maddux | Greg Maddux | Mark Mulder | | 589 | 454 | 135 |
| 2005-08-12 | @ CHN | 116 | L 1-4 | 73-43 | 1 | 39,717 | Jason Marquis | Carlos Zambrano | Carlos Zambrano | Jason Marquis | | 590 | 458 | 132 |
| 2005-08-13 | @ CHN | 117 | W 5-2 | 74-43 | 1 | 39,923 | Chris Carpenter | Jerome Williams | Chris Carpenter | Jerome Williams | | 595 | 460 | 135 |
| 2005-08-14 | @ CHN | 118 | L 4-5 | 74-44 | 1 | 39,311 | Matt Morris | Mark Prior | Mark Prior | Matt Morris | Ryan Dempster | 599 | 465 | 134 |
| 2005-08-16 | vs ARI | 119 | W 8-2 | 75-44 | 1 | 42,198 | Jeff Suppan | Brad Halsey | Jeff Suppan | Brad Halsey | | 607 | 467 | 140 |
| 2005-08-17 | vs ARI | 120 | W 5-0 | 76-44 | 1 | 41,407 | Mark Mulder | Brandon Webb | Mark Mulder | Brandon Webb | | 612 | 467 | 145 |
| 2005-08-18 | vs ARI | 121 | L 2-9 | 76-45 | 1 | 44,625 | Jason Marquis | Claudio Vargas | Claudio Vargas | Jason Marquis | | 614 | 476 | 138 |
| 2005-08-19 | vs SFN | 122 | W 5-4 | 77-45 | 1 | 46,200 | Chris Carpenter | Brad Hennessey | Julian Tavarez | Jeremy Accardo | | 619 | 480 | 139 |
| 2005-08-20 | vs SFN | 123 | W 4-2 | 78-45 | 1 | 47,169 | Matt Morris | Kevin Correia | Matt Morris | Kevin Correia | Jason Isringhausen | 623 | 482 | 141 |
| 2005-08-21 | vs SFN | 124 | L 2-4 | 78-46 | 1 | 46,113 | Jeff Suppan | Jason Schmidt | Jason Schmidt | Jeff Suppan | Armando Benitez | 625 | 486 | 139 |
| 2005-08-22 | @ PIT | 125 | W 3-1 | 79-46 | 1 | 23,751 | Mark Mulder | Josh Fogg | Mark Mulder | Josh Fogg | Jason Isringhausen | 628 | 487 | 141 |
| 2005-08-23 | @ PIT | 126 | L 0-10 | 79-47 | 1 | 23,948 | Jason Marquis | Zach Duke | Salomon Torres | Jason Marquis | | 628 | 497 | 131 |
| 2005-08-24 | @ PIT | 127 | W 8-3 | 80-47 | 1 | 21,506 | Chris Carpenter | Kip Wells | Chris Carpenter | Kip Wells | | 636 | 500 | 136 |
| 2005-08-25 | @ PIT | 128 | W 6-3 | 81-47 | 1 | 24,626 | Matt Morris | David Williams | Matt Morris | David Williams | Jason Isringhausen | 642 | 503 | 139 |
| 2005-08-26 | @ WAS | 129 | L 1-4 | 81-48 | 1 | 37,885 | Jeff Suppan | Esteban Loaiza | Esteban Loaiza | Jeff Suppan | Chad Cordero | 643 | 507 | 136 |
| 2005-08-27 | @ WAS | 130 | W 6-0 | 82-48 | 1 | 44,254 | Jason Marquis | Matt White | Jason Marquis | Matt White | | 649 | 507 | 142 |
| 2005-08-28 | @ WAS | 131 | W 6-0 | 83-48 | 1 | 41,130 | Cal Eldred | John Halama | Brad Thompson | John Halama | | 655 | 507 | 148 |
| 2005-08-29 | @ FLO | 132 | W 6-1 | 84-48 | 1 | 18,388 | Chris Carpenter | A.J. Burnett | Chris Carpenter | A.J. Burnett | | 661 | 508 | 153 |
| 2005-08-30 | @ FLO | 133 | L 6-7 | 84-49 | 1 | 20,073 | Matt Morris | Ismael Valdez | Guillermo Mota | Matt Morris | Todd Jones | 667 | 515 | 152 |
| 2005-08-31 | @ FLO | 134 | W 10-5 | 85-49 | 1 | 20,656 | Jeff Suppan | Jason Vargas | Jeff Suppan | Jason Vargas | | 677 | 520 | 157 |
| 2005-09-02 | @ HOU | 135 | L 5-6 | 85-50 | 1 | 38,511 | Mark Mulder | Ezequiel Astacio | Chad Qualls | Julian Tavarez | | 682 | 526 | 156 |
| 2005-09-03 | @ HOU | 136 | W 4-2 | 86-50 | 1 | 42,817 | Chris Carpenter | Roger Clemens | Chris Carpenter | Russ Springer | | 686 | 528 | 158 |
| 2005-09-04 | @ HOU | 137 | W 4-1 | 87-50 | 1 | 38,277 | Jason Marquis | Wandy Rodriguez | Jason Marquis | Wandy Rodriguez | | 690 | 529 | 161 |
| 2005-09-05 | vs CHN | 138 | W 6-4 | 88-50 | 1 | 49,646 | Jeff Suppan | Mark Prior | Ray King | Roberto Novoa | Julian Tavarez | 696 | 533 | 163 |
| 2005-09-06 | vs CHN | 139 | L 2-5 | 88-51 | 1 | 47,292 | Matt Morris | Glendon Rusch | Glendon Rusch | Matt Morris | Ryan Dempster | 698 | 538 | 160 |
| 2005-09-07 | vs CHN | 140 | L 1-2 | 88-52 | 1 | 47,789 | Mark Mulder | Greg Maddux | Greg Maddux | Mark Mulder | Ryan Dempster | 699 | 540 | 159 |
| 2005-09-08 | vs NYN | 141 | W 5-0 | 89-52 | 1 | 47,422 | Chris Carpenter | Kris Benson | Chris Carpenter | Kris Benson | | 704 | 540 | 164 |
| 2005-09-09 | vs NYN | 142 | W 3-2 | 90-52 | 1 | 45,616 | Jason Marquis | Jae Weong Seo | Jason Marquis | Jae Weong Seo | Jason Isringhausen | 707 | 542 | 165 |
| 2005-09-10 | vs NYN | 143 | W 4-2 | 91-52 | 1 | 48,465 | Jeff Suppan | Steve Trachsel | Jeff Suppan | Steve Trachsel | Jason Isringhausen | 711 | 544 | 167 |
| 2005-09-11 | vs NYN | 144 | L 2-7 | 91-53 | 1 | 45,884 | Matt Morris | Pedro Martinez | Pedro Martinez | Matt Morris | | 713 | 551 | 162 |
| 2005-09-12 | vs PIT | 145 | W 4-3 | 92-53 | 1 | 40,064 | Mark Mulder | Mark Redman | Jason Isringhausen | Salomon Torres | | 717 | 554 | 163 |
| 2005-09-13 | vs PIT | 146 | W 5-4 | 93-53 | 1 | 40,599 | Chris Carpenter | Ian Snell | Brad Thompson | Rick White | | 722 | 558 | 164 |
| 2005-09-14 | vs PIT | 147 | L 3-5 | 93-54 | 1 | 40,172 | Jason Marquis | Oliver Perez | Ryan Vogelsong | Jason Marquis | Mike Gonzalez | 725 | 563 | 162 |
| 2005-09-15 | @ CHN | 148 | W 6-1 | 94-54 | 1 | 37,849 | Jeff Suppan | Mark Prior | Jeff Suppan | Mark Prior | | 731 | 564 | 167 |
| 2005-09-16 | @ CHN | 149 | L 3-5 | 94-55 | 1 | 38,080 | Matt Morris | Glendon Rusch | Glendon Rusch | Matt Morris | Ryan Dempster | 734 | 569 | 165 |
| 2005-09-17 | @ CHN | 150 | W 5-1 | 95-55 | 1 | 39,269 | Mark Mulder | Greg Maddux | Mark Mulder | Greg Maddux | | 739 | 570 | 169 |
| 2005-09-18 | @ CHN | 151 | L 4-7 | 95-56 | 1 | 38,182 | Chris Carpenter | Carlos Zambrano | Carlos Zambrano | Anthony Reyes | | 743 | 577 | 166 |
| 2005-09-20 | @ CIN | 152 | L 5-6 | 95-57 | 1 | 16,587 | Jeff Suppan | Randy Keisler | Josh Hancock | Ray King | David Weathers | 748 | 583 | 165 |
| 2005-09-21 | @ CIN | 153 | W 5-1 | 96-57 | 1 | 16,784 | Jason Marquis | Ramon Ortiz | Jason Marquis | Ramon Ortiz | | 753 | 584 | 169 |
| 2005-09-22 | @ CIN | 154 | L 2-6 | 96-58 | 1 | 17,461 | Matt Morris | Brandon Claussen | Todd Coffey | Ray King | | 755 | 590 | 165 |
| 2005-09-23 | @ MIL | 155 | L 6-9 | 96-59 | 1 | 22,472 | Chris Carpenter | Chris Capuano | Chris Capuano | Chris Carpenter | Derrick Turnbow | 761 | 599 | 162 |
| 2005-09-24 | @ MIL | 156 | L 7-8 | 96-60 | 1 | 33,506 | Mark Mulder | Gary Glover | Gary Glover | Mark Mulder | Derrick Turnbow | 768 | 607 | 161 |
| 2005-09-25 | @ MIL | 157 | W 2-0 | 97-60 | 1 | 20,150 | Jeff Suppan | Doug Davis | Jeff Suppan | Doug Davis | Jason Isringhausen | 770 | 607 | 163 |
| 2005-09-27 | vs HOU | 158 | L 1-3 | 97-61 | 1 | 40,260 | Matt Morris | Roy Oswalt | Roy Oswalt | Matt Morris | Brad Lidge | 771 | 610 | 161 |
| 2005-09-28 | vs HOU | 159 | L 6-7 | 97-62 | 1 | 40,616 | Chris Carpenter | Brandon Backe | Chad Qualls | Jason Isringhausen | Brad Lidge | 777 | 617 | 160 |
| 2005-09-30 | vs CIN | 160 | W 12-6 | 98-62 | 1 | 47,257 | Mark Mulder | Randy Keisler | Alberto Reyes | Luke Hudson | | 789 | 623 | 166 |
| 2005-10-01 | vs CIN | 161 | W 9-6 | 99-62 | 1 | 49,487 | Jason Marquis | Ramon Ortiz | Randy Flores | Allan Simpson | Jason Isringhausen | 798 | 629 | 169 |
| 2005-10-02 | vs CIN | 162 | W 7-5 | 100-62 | 1 | 50,434 | Matt Morris | Brandon Claussen | Brad Thompson | Brandon Claussen | Jason Isringhausen | 805 | 634 | 171 |