| 2005-04-05 | vs LAN | 1 | W 4-2 | 1-0 | 2 | 42,788 | Jason Schmidt | Derek Lowe | Jason Schmidt | Derek Lowe | Armando Benitez | 4 | 2 | 2 |
| 2005-04-06 | vs LAN | 2 | L 4-10 | 1-1 | 5 | 42,433 | Kirk Rueter | Odalis Perez | Odalis Perez | Kirk Rueter | | 8 | 12 | -4 |
| 2005-04-07 | vs LAN | 3 | L 0-6 | 1-2 | 5 | 40,536 | Brett Tomko | Jeff Weaver | Jeff Weaver | Brett Tomko | | 8 | 18 | -10 |
| 2005-04-08 | vs COL | 4 | W 10-8 | 2-2 | 4 | 37,015 | Noah Lowry | Jeff Francis | Jason Christiansen | Brian Fuentes | | 18 | 26 | -8 |
| 2005-04-09 | vs COL | 5 | W 4-2 | 3-2 | 3 | 37,993 | Jerome Williams | Jamey Wright | Scott Eyre | Scott Dohmann | Armando Benitez | 22 | 28 | -6 |
| 2005-04-10 | vs COL | 6 | W 11-4 | 4-2 | 2 | 38,588 | Jason Schmidt | Joe Kennedy | Jason Schmidt | Joe Kennedy | | 33 | 32 | 1 |
| 2005-04-12 | @ LAN | 7 | L 8-9 | 4-3 | 4 | 55,892 | Kirk Rueter | Jeff Weaver | Giovanni Carrara | Armando Benitez | | 41 | 41 | 0 |
| 2005-04-13 | @ LAN | 8 | L 1-4 | 4-4 | 4 | 46,514 | Brett Tomko | Odalis Perez | Odalis Perez | Brett Tomko | Yhency Brazoban | 42 | 45 | -3 |
| 2005-04-15 | @ COL | 9 | W 13-6 | 5-4 | 3 | 22,551 | Noah Lowry | Jamey Wright | Noah Lowry | Jamey Wright | | 55 | 51 | 4 |
| 2005-04-16 | @ COL | 10 | L 4-5 | 5-5 | 3 | 23,439 | Jason Schmidt | Joe Kennedy | Joe Kennedy | Jason Schmidt | Chin-hui Tsao | 59 | 56 | 3 |
| 2005-04-17 | @ COL | 11 | W 8-6 | 6-5 | 2 | 27,107 | Kirk Rueter | Jason Jennings | Matt Herges | Byung-Hyun Kim | Armando Benitez | 67 | 62 | 5 |
| 2005-04-18 | @ SDN | 12 | L 2-7 | 6-6 | 3 | 29,523 | Brett Tomko | Jake Peavy | Jake Peavy | Brett Tomko | | 69 | 69 | 0 |
| 2005-04-19 | @ SDN | 13 | L 2-5 | 6-7 | 4 | 29,544 | Jerome Williams | Brian Lawrence | Brian Lawrence | Jerome Williams | Trevor Hoffman | 71 | 74 | -3 |
| 2005-04-20 | vs ARI | 14 | L 1-2 | 6-8 | 4 | 36,955 | Noah Lowry | Javier Vazquez | Javier Vazquez | Noah Lowry | Brandon Lyon | 72 | 76 | -4 |
| 2005-04-21 | vs ARI | 15 | W 4-3 | 7-8 | 4 | 34,824 | Jason Schmidt | Russ Ortiz | Tyler Walker | Mike Gosling | | 76 | 79 | -3 |
| 2005-04-22 | vs MIL | 16 | L 1-6 | 7-9 | 4 | 36,994 | Kirk Rueter | Victor Santos | Victor Santos | Kirk Rueter | | 77 | 85 | -8 |
| 2005-04-23 | vs MIL | 17 | W 6-2 | 8-9 | 3 | 37,341 | Brett Tomko | Chris Capuano | Brett Tomko | Chris Capuano | Armando Benitez | 83 | 87 | -4 |
| 2005-04-24 | vs MIL | 18 | L 5-8 | 8-10 | 3 | 36,604 | Jerome Williams | Gary Glover | Gary Glover | Jerome Williams | Derrick Turnbow | 88 | 95 | -7 |
| 2005-04-25 | vs SDN | 19 | L 3-5 | 8-11 | 4 | 35,655 | Noah Lowry | Woody Williams | Woody Williams | Noah Lowry | Trevor Hoffman | 91 | 100 | -9 |
| 2005-04-26 | vs SDN | 20 | W 6-5 | 9-11 | 3 | 36,063 | Jason Schmidt | Adam Eaton | Armando Benitez | Akinori Otsuka | | 97 | 105 | -8 |
| 2005-04-27 | vs SDN | 21 | W 10-3 | 10-11 | 3 | 38,376 | Kirk Rueter | Tim Redding | Kirk Rueter | Tim Redding | | 107 | 108 | -1 |
| 2005-04-29 | @ PIT | 22 | W 3-2 | 11-11 | 3 | 24,209 | Brett Tomko | Mark Redman | Brett Tomko | Mark Redman | | 110 | 110 | 0 |
| 2005-04-30 | @ PIT | 23 | W 7-6 | 12-11 | 3 | 23,972 | Noah Lowry | David Williams | Tyler Walker | David Williams | Jim Brower | 117 | 116 | 1 |
| 2005-05-01 | @ PIT | 24 | W 8-3 | 13-11 | 3 | 22,100 | Brad Hennessey | Oliver Perez | Brad Hennessey | Oliver Perez | | 125 | 119 | 6 |
| 2005-05-02 | @ ARI | 25 | W 9-8 | 14-11 | 3 | 25,317 | Jason Schmidt | Russ Ortiz | Jim Brower | Brian Bruney | Tyler Walker | 134 | 127 | 7 |
| 2005-05-03 | @ ARI | 26 | L 2-3 | 14-12 | 3 | 28,072 | Kirk Rueter | Brad Halsey | Javier Lopez | Matt Herges | Brandon Lyon | 136 | 130 | 6 |
| 2005-05-04 | @ ARI | 27 | L 2-6 | 14-13 | 3 | 21,367 | Brett Tomko | Brandon Webb | Brandon Webb | Brett Tomko | | 138 | 136 | 2 |
| 2005-05-06 | vs WAS | 28 | L 3-9 | 14-14 | 4 | 40,425 | Noah Lowry | Tomo Ohka | Jon Rauch | Noah Lowry | | 141 | 145 | -4 |
| 2005-05-07 | vs WAS | 29 | L 8-11 | 14-15 | 4 | 40,220 | Jason Schmidt | John Patterson | Luis Ayala | Jeremy Accardo | Chad Cordero | 149 | 156 | -7 |
| 2005-05-08 | vs WAS | 30 | W 4-3 | 15-15 | 4 | 36,903 | Kirk Rueter | Esteban Loaiza | Jason Christiansen | Jon Rauch | | 153 | 159 | -6 |
| 2005-05-09 | vs PIT | 31 | W 2-1 | 16-15 | 4 | 34,037 | Brett Tomko | Mark Redman | Brett Tomko | Mark Redman | | 155 | 160 | -5 |
| 2005-05-10 | vs PIT | 32 | L 2-5 | 16-16 | 4 | 35,668 | Jeff Fassero | David Williams | David Williams | Jim Brower | Jose Mesa | 157 | 165 | -8 |
| 2005-05-11 | vs PIT | 33 | L 2-7 | 16-17 | 4 | 39,200 | Noah Lowry | Josh Fogg | Josh Fogg | Noah Lowry | Rick White | 159 | 172 | -13 |
| 2005-05-12 | @ HOU | 34 | W 6-3 | 17-17 | 4 | 29,126 | Brad Hennessey | Andy Pettitte | Brad Hennessey | Andy Pettitte | Tyler Walker | 165 | 175 | -10 |
| 2005-05-13 | @ HOU | 35 | W 4-2 | 18-17 | 4 | 31,365 | Kirk Rueter | Ezequiel Astacio | Kirk Rueter | Ezequiel Astacio | Tyler Walker | 169 | 177 | -8 |
| 2005-05-14 | @ HOU | 36 | L 1-4 | 18-18 | 4 | 41,323 | Brett Tomko | Roger Clemens | Roger Clemens | Brett Tomko | Brad Lidge | 170 | 181 | -11 |
| 2005-05-15 | @ HOU | 37 | L 0-9 | 18-19 | 4 | 33,633 | Jeff Fassero | Brandon Backe | Brandon Backe | Jeff Fassero | | 170 | 190 | -20 |
| 2005-05-17 | @ COL | 38 | L 4-9 | 18-20 | 4 | 20,026 | Noah Lowry | Joe Kennedy | Joe Kennedy | Noah Lowry | | 174 | 199 | -25 |
| 2005-05-18 | @ COL | 39 | W 3-2 | 19-20 | 4 | 18,620 | Brad Hennessey | Shawn Chacon | Jim Brower | Brian Fuentes | Tyler Walker | 177 | 201 | -24 |
| 2005-05-19 | @ COL | 40 | L 1-3 | 19-21 | 4 | 21,877 | Brett Tomko | Jeff Francis | Jeff Francis | Brett Tomko | Brian Fuentes | 178 | 204 | -26 |
| 2005-05-20 | vs OAK | 41 | L 4-8 | 19-22 | 4 | 42,701 | Kirk Rueter | Joe Blanton | Keiichi Yabu | Kirk Rueter | | 182 | 212 | -30 |
| 2005-05-21 | vs OAK | 42 | W 3-2 | 20-22 | 4 | 43,069 | Jeff Fassero | Dan Haren | Jeff Fassero | Dan Haren | Tyler Walker | 185 | 214 | -29 |
| 2005-05-22 | vs OAK | 43 | W 3-1 | 21-22 | 4 | 42,452 | Noah Lowry | Barry Zito | Noah Lowry | Barry Zito | Tyler Walker | 188 | 215 | -27 |
| 2005-05-24 | vs LAN | 44 | W 5-3 | 22-22 | 4 | 39,226 | Jason Schmidt | Jeff Weaver | Jason Schmidt | Jeff Weaver | Tyler Walker | 193 | 218 | -25 |
| 2005-05-25 | vs LAN | 45 | W 10-2 | 23-22 | 4 | 38,778 | Brett Tomko | Wilson Alvarez | Brett Tomko | Wilson Alvarez | | 203 | 220 | -17 |
| 2005-05-26 | vs LAN | 46 | L 4-6 | 23-23 | 4 | 40,147 | Kirk Rueter | Brad Penny | Yhency Brazoban | Jason Christiansen | Eric Gagne | 207 | 226 | -19 |
| 2005-05-27 | vs SDN | 47 | L 3-9 | 23-24 | 4 | 36,735 | Brad Hennessey | Brian Lawrence | Brian Lawrence | Brad Hennessey | | 210 | 235 | -25 |
| 2005-05-28 | vs SDN | 48 | L 3-5 | 23-25 | 4 | 41,311 | Noah Lowry | Tim Stauffer | Rudy Seanez | Jeff Fassero | Trevor Hoffman | 213 | 240 | -27 |
| 2005-05-29 | vs SDN | 49 | L 6-9 | 23-26 | 4 | 41,923 | Jason Schmidt | Adam Eaton | Chris Hammond | Tyler Walker | Trevor Hoffman | 219 | 249 | -30 |
| 2005-05-31 | @ PHI | 50 | L 2-5 | 23-27 | 4 | 23,456 | Brett Tomko | Randy Wolf | Randy Wolf | Brett Tomko | | 221 | 254 | -33 |
| 2005-06-01 | @ PHI | 51 | L 6-10 | 23-28 | 4 | 24,546 | Kirk Rueter | Cory Lidle | Ryan Madson | LaTroy Hawkins | | 227 | 264 | -37 |
| 2005-06-02 | @ PHI | 52 | L 5-6 | 23-29 | 4 | 25,589 | Brad Hennessey | Jon Lieber | Jon Lieber | Brad Hennessey | Billy Wagner | 232 | 270 | -38 |
| 2005-06-04 | @ NYN | 53 | L 1-5 | 23-30 | 4 | 37,194 | Noah Lowry | Tom Glavine | Tom Glavine | Noah Lowry | | 233 | 275 | -42 |
| 2005-06-05 | @ NYN | 54 | W 6-3 | 24-31 | 4 | 0 | Brett Tomko | Kazuhisa Ishii | Brett Tomko | Kazuhisa Ishii | Tyler Walker | 239 | 278 | -39 |
| 2005-06-05 | @ NYN | 55 | L 1-12 | 24-31 | 4 | 33,460 | Jason Schmidt | Kris Benson | Kris Benson | Jason Schmidt | | 240 | 290 | -50 |
| 2005-06-07 | vs KCA | 56 | L 1-8 | 24-32 | 4 | 37,037 | Kirk Rueter | D.J. Carrasco | D.J. Carrasco | Kirk Rueter | | 241 | 298 | -57 |
| 2005-06-08 | vs KCA | 57 | L 1-4 | 24-33 | 4 | 36,578 | Jeff Fassero | Runelvys Hernandez | Runelvys Hernandez | Jeff Fassero | Mike MacDougal | 242 | 302 | -60 |
| 2005-06-09 | vs KCA | 58 | W 9-7 | 25-33 | 4 | 38,956 | Noah Lowry | Jose Lima | Scott Munter | Leo Nunez | Tyler Walker | 251 | 309 | -58 |
| 2005-06-10 | vs CLE | 59 | L 2-10 | 25-34 | 4 | 37,102 | Brett Tomko | CC Sabathia | CC Sabathia | Brett Tomko | | 253 | 319 | -66 |
| 2005-06-11 | vs CLE | 60 | L 6-7 | 25-35 | 4 | 39,961 | Jason Schmidt | Jason Davis | Jason Davis | Jason Schmidt | Bob Wickman | 259 | 326 | -67 |
| 2005-06-12 | vs CLE | 61 | L 3-5 | 25-36 | 4 | 41,500 | Kirk Rueter | Cliff Lee | Cliff Lee | Kirk Rueter | Bob Wickman | 262 | 331 | -69 |
| 2005-06-14 | @ MIN | 62 | L 3-4 | 25-37 | 4 | 23,145 | Jesse Foppert | Johan Santana | Jesse Crain | Jeff Fassero | | 265 | 335 | -70 |
| 2005-06-15 | @ MIN | 63 | W 8-4 | 26-37 | 4 | 25,613 | Noah Lowry | Kyle Lohse | Noah Lowry | Kyle Lohse | | 273 | 339 | -66 |
| 2005-06-16 | @ MIN | 64 | W 14-7 | 27-37 | 4 | 18,815 | Brett Tomko | Joe Mays | Jason Christiansen | Joe Nathan | | 287 | 346 | -59 |
| 2005-06-17 | @ DET | 65 | W 4-0 | 28-37 | 4 | 34,397 | Jason Schmidt | Nate Robertson | Jason Schmidt | Nate Robertson | Tyler Walker | 291 | 346 | -55 |
| 2005-06-18 | @ DET | 66 | L 2-8 | 28-38 | 4 | 38,461 | Kirk Rueter | Jason Johnson | Jason Johnson | Kirk Rueter | | 293 | 354 | -61 |
| 2005-06-19 | @ DET | 67 | L 8-10 | 28-39 | 4 | 35,191 | Jesse Foppert | Mike Maroth | Jamie Walker | Scott Eyre | | 301 | 364 | -63 |
| 2005-06-20 | vs ARI | 68 | W 8-3 | 29-39 | 4 | 38,891 | Noah Lowry | Javier Vazquez | Noah Lowry | Javier Vazquez | | 309 | 367 | -58 |
| 2005-06-21 | vs ARI | 69 | L 4-6 | 29-40 | 4 | 37,942 | Brett Tomko | Claudio Vargas | Claudio Vargas | Brett Tomko | Brian Bruney | 313 | 373 | -60 |
| 2005-06-22 | vs ARI | 70 | W 4-0 | 30-40 | 4 | 36,349 | Jason Schmidt | Brad Halsey | Jason Schmidt | Brad Halsey | | 317 | 373 | -56 |
| 2005-06-23 | vs ARI | 71 | L 2-7 | 30-41 | 4 | 39,739 | Kirk Rueter | Brandon Webb | Brandon Webb | Kirk Rueter | | 319 | 380 | -61 |
| 2005-06-24 | @ OAK | 72 | L 3-4 | 30-42 | 4 | 40,485 | Jeff Fassero | Joe Blanton | Joe Blanton | Jeff Fassero | Justin Duchscherer | 322 | 384 | -62 |
| 2005-06-25 | @ OAK | 73 | L 3-6 | 30-43 | 4 | 46,763 | Noah Lowry | Dan Haren | Dan Haren | Noah Lowry | | 325 | 390 | -65 |
| 2005-06-26 | @ OAK | 74 | L 0-16 | 30-44 | 4 | 44,633 | Brett Tomko | Rich Harden | Rich Harden | Brett Tomko | | 325 | 406 | -81 |
| 2005-06-28 | @ ARI | 75 | W 11-3 | 31-44 | 4 | 30,640 | Jason Schmidt | Brad Halsey | Jason Schmidt | Brad Halsey | | 336 | 409 | -73 |
| 2005-06-29 | @ ARI | 76 | W 4-2 | 32-44 | 4 | 22,991 | Kirk Rueter | Brandon Webb | Jason Christiansen | Brandon Webb | Tyler Walker | 340 | 411 | -71 |
| 2005-06-30 | @ ARI | 77 | W 9-2 | 33-44 | 4 | 21,751 | Noah Lowry | Shawn Estes | Noah Lowry | Shawn Estes | Brett Tomko | 349 | 413 | -64 |
| 2005-07-01 | @ SDN | 78 | W 3-2 | 34-44 | 4 | 41,847 | Kevin Correia | Jake Peavy | Jason Christiansen | Rudy Seanez | Tyler Walker | 352 | 415 | -63 |
| 2005-07-02 | @ SDN | 79 | L 3-5 | 34-45 | 4 | 42,524 | Jeff Fassero | Woody Williams | Woody Williams | Jeff Fassero | Trevor Hoffman | 355 | 420 | -65 |
| 2005-07-03 | @ SDN | 80 | L 6-9 | 34-46 | 4 | 42,536 | Jason Schmidt | Tim Stauffer | Tim Stauffer | Jason Schmidt | Trevor Hoffman | 361 | 429 | -68 |
| 2005-07-04 | vs CIN | 81 | L 10-11 | 34-47 | 4 | 40,333 | Kirk Rueter | Elizardo Ramirez | Ryan Wagner | Jeremy Accardo | Matt Belisle | 371 | 440 | -69 |
| 2005-07-05 | vs CIN | 82 | L 4-7 | 34-48 | 4 | 36,254 | Noah Lowry | Eric Milton | Eric Milton | Noah Lowry | | 375 | 447 | -72 |
| 2005-07-06 | vs CIN | 83 | W 7-2 | 35-48 | 4 | 33,666 | Kevin Correia | Luke Hudson | Kevin Correia | Luke Hudson | | 382 | 449 | -67 |
| 2005-07-07 | vs CIN | 84 | W 5-1 | 36-48 | 4 | 35,543 | Brett Tomko | Aaron Harang | Brett Tomko | Aaron Harang | | 387 | 450 | -63 |
| 2005-07-08 | vs SLN | 85 | L 1-3 | 36-49 | 4 | 41,405 | Jason Schmidt | Mark Mulder | Mark Mulder | Jason Schmidt | Jason Isringhausen | 388 | 453 | -65 |
| 2005-07-09 | vs SLN | 86 | W 2-0 | 37-49 | 4 | 42,423 | Brad Hennessey | Matt Morris | Brad Hennessey | Matt Morris | Tyler Walker | 390 | 453 | -63 |
| 2005-07-10 | vs SLN | 87 | L 3-4 | 37-50 | 4 | 41,925 | Noah Lowry | Jeff Suppan | Jeff Suppan | Noah Lowry | Jason Isringhausen | 393 | 457 | -64 |
| 2005-07-14 | @ LAN | 88 | W 4-3 | 38-50 | 4 | 46,234 | Jason Schmidt | Brad Penny | Jason Schmidt | D.J. Houlton | Tyler Walker | 397 | 460 | -63 |
| 2005-07-15 | @ LAN | 89 | W 6-0 | 39-50 | 4 | 51,057 | Noah Lowry | Derek Lowe | Noah Lowry | Derek Lowe | | 403 | 460 | -57 |
| 2005-07-16 | @ LAN | 90 | L 4-5 | 39-51 | 4 | 48,490 | Brett Tomko | Odalis Perez | Steve Schmoll | Tyler Walker | | 407 | 465 | -58 |
| 2005-07-17 | @ LAN | 91 | W 4-1 | 40-51 | 4 | 47,719 | Brad Hennessey | Jeff Weaver | Scott Eyre | Yhency Brazoban | LaTroy Hawkins | 411 | 466 | -55 |
| 2005-07-18 | vs ATL | 92 | L 1-6 | 40-52 | 4 | 42,277 | Kevin Correia | Jorge Sosa | Jorge Sosa | Kevin Correia | | 412 | 472 | -60 |
| 2005-07-19 | vs ATL | 93 | W 5-4 | 41-52 | 4 | 42,494 | Jason Schmidt | Horacio Ramirez | Tyler Walker | Danny Kolb | | 417 | 476 | -59 |
| 2005-07-20 | vs ATL | 94 | L 1-4 | 41-53 | 4 | 42,371 | Noah Lowry | John Smoltz | John Smoltz | Noah Lowry | Chris Reitsma | 418 | 480 | -62 |
| 2005-07-22 | vs FLO | 95 | W 8-5 | 42-53 | 4 | 39,876 | Brett Tomko | Dontrelle Willis | Brett Tomko | Dontrelle Willis | Tyler Walker | 426 | 485 | -59 |
| 2005-07-23 | vs FLO | 96 | L 4-16 | 42-54 | 4 | 43,017 | Brad Hennessey | Josh Beckett | Josh Beckett | Brad Hennessey | | 430 | 501 | -71 |
| 2005-07-24 | vs FLO | 97 | L 1-4 | 42-55 | 4 | 42,019 | Kevin Correia | A.J. Burnett | A.J. Burnett | Kevin Correia | Todd Jones | 431 | 505 | -74 |
| 2005-07-25 | @ CHN | 98 | L 2-3 | 42-56 | 4 | 39,477 | Jason Schmidt | Rich Hill | Ryan Dempster | Tyler Walker | | 433 | 508 | -75 |
| 2005-07-26 | @ CHN | 99 | W 3-2 | 43-56 | 4 | 39,002 | Noah Lowry | Greg Maddux | Jason Christiansen | Glendon Rusch | Tyler Walker | 436 | 510 | -74 |
| 2005-07-27 | @ CHN | 100 | L 3-4 | 43-57 | 4 | 38,877 | Brett Tomko | Carlos Zambrano | Ryan Dempster | Kevin Correia | | 439 | 514 | -75 |
| 2005-07-28 | @ MIL | 101 | W 3-0 | 44-57 | 4 | 22,252 | Brad Hennessey | Victor Santos | Brad Hennessey | Victor Santos | Tyler Walker | 442 | 514 | -72 |
| 2005-07-29 | @ MIL | 102 | W 7-6 | 45-57 | 4 | 28,652 | Kirk Rueter | Doug Davis | Jeff Fassero | Matt Wise | Tyler Walker | 449 | 520 | -71 |
| 2005-07-30 | @ MIL | 103 | L 1-7 | 45-58 | 4 | 38,462 | Jason Schmidt | Ben Sheets | Ben Sheets | Jason Schmidt | | 450 | 527 | -77 |
| 2005-07-31 | @ MIL | 104 | L 1-5 | 45-59 | 4 | 36,148 | Noah Lowry | Chris Capuano | Chris Capuano | Noah Lowry | | 451 | 532 | -81 |
| 2005-08-02 | vs COL | 105 | L 3-4 | 45-60 | 4 | 39,349 | Brett Tomko | Jamey Wright | Jamey Wright | Brett Tomko | Brian Fuentes | 454 | 536 | -82 |
| 2005-08-03 | vs COL | 106 | L 2-3 | 45-61 | 4 | 36,239 | Brad Hennessey | Byung-Hyun Kim | Dan Miceli | Tyler Walker | Brian Fuentes | 456 | 539 | -83 |
| 2005-08-04 | vs COL | 107 | W 6-4 | 46-61 | 4 | 40,721 | Kevin Correia | Jose Acevedo | Scott Munter | Dan Miceli | Tyler Walker | 462 | 543 | -81 |
| 2005-08-05 | vs HOU | 108 | W 4-0 | 47-61 | 4 | 39,686 | Jason Schmidt | Andy Pettitte | Jason Schmidt | Andy Pettitte | | 466 | 543 | -77 |
| 2005-08-06 | vs HOU | 109 | W 5-2 | 48-61 | 4 | 41,959 | Noah Lowry | Roy Oswalt | Noah Lowry | Roy Oswalt | | 471 | 545 | -74 |
| 2005-08-07 | vs HOU | 110 | L 1-8 | 48-62 | 4 | 42,947 | Brian Cooper | Roger Clemens | Roger Clemens | Scott Eyre | | 472 | 553 | -81 |
| 2005-08-09 | @ ATL | 111 | L 1-7 | 48-63 | 4 | 27,230 | Brad Hennessey | Horacio Ramirez | Horacio Ramirez | Brad Hennessey | | 473 | 560 | -87 |
| 2005-08-10 | @ ATL | 112 | L 4-5 | 48-64 | 4 | 24,032 | Kevin Correia | John Smoltz | Blaine Boyer | Brian Cooper | | 477 | 565 | -88 |
| 2005-08-11 | @ ATL | 113 | W 5-3 | 49-64 | 4 | 26,577 | Jason Schmidt | Tim Hudson | Jason Schmidt | Tim Hudson | Tyler Walker | 482 | 568 | -86 |
| 2005-08-12 | @ FLO | 114 | W 1-0 | 50-64 | 4 | 25,118 | Noah Lowry | Dontrelle Willis | Noah Lowry | Dontrelle Willis | Tyler Walker | 483 | 568 | -85 |
| 2005-08-13 | @ FLO | 115 | L 1-2 | 50-65 | 4 | 30,837 | Brett Tomko | Josh Beckett | Josh Beckett | Brett Tomko | | 484 | 570 | -86 |
| 2005-08-14 | @ FLO | 116 | L 1-4 | 50-66 | 4 | 26,170 | Brad Hennessey | A.J. Burnett | A.J. Burnett | Brad Hennessey | Todd Jones | 485 | 574 | -89 |
| 2005-08-15 | @ CIN | 117 | W 7-3 | 51-66 | 4 | 17,777 | Kevin Correia | Aaron Harang | Kevin Correia | Aaron Harang | | 492 | 577 | -85 |
| 2005-08-16 | @ CIN | 118 | W 10-8 | 52-66 | 4 | 16,954 | Jason Schmidt | Eric Milton | Jeff Fassero | Jason Standridge | Tyler Walker | 502 | 585 | -83 |
| 2005-08-17 | @ CIN | 119 | W 3-2 | 53-66 | 4 | 19,867 | Noah Lowry | Luke Hudson | Noah Lowry | Luke Hudson | LaTroy Hawkins | 505 | 587 | -82 |
| 2005-08-18 | @ CIN | 120 | L 2-4 | 53-67 | 4 | 23,012 | Brett Tomko | Ramon Ortiz | Ramon Ortiz | Brett Tomko | David Weathers | 507 | 591 | -84 |
| 2005-08-19 | @ SLN | 121 | L 4-5 | 53-68 | 4 | 46,200 | Brad Hennessey | Chris Carpenter | Julian Tavarez | Jeremy Accardo | | 511 | 596 | -85 |
| 2005-08-20 | @ SLN | 122 | L 2-4 | 53-69 | 4 | 47,169 | Kevin Correia | Matt Morris | Matt Morris | Kevin Correia | Jason Isringhausen | 513 | 600 | -87 |
| 2005-08-21 | @ SLN | 123 | W 4-2 | 54-69 | 4 | 46,113 | Jason Schmidt | Jeff Suppan | Jason Schmidt | Jeff Suppan | Armando Benitez | 517 | 602 | -85 |
| 2005-08-22 | vs PHI | 124 | W 5-0 | 55-69 | 4 | 38,947 | Noah Lowry | Jon Lieber | Noah Lowry | Jon Lieber | | 522 | 602 | -80 |
| 2005-08-23 | vs PHI | 125 | L 2-10 | 55-70 | 4 | 37,892 | Brett Tomko | Vicente Padilla | Vicente Padilla | Brett Tomko | | 524 | 612 | -88 |
| 2005-08-24 | vs PHI | 126 | L 4-7 | 55-71 | 4 | 36,812 | Brad Hennessey | Cory Lidle | Rob Tejeda | Brad Hennessey | Billy Wagner | 528 | 619 | -91 |
| 2005-08-26 | vs NYN | 127 | L 0-1 | 55-72 | 4 | 39,591 | Kevin Correia | Steve Trachsel | Steve Trachsel | Kevin Correia | Braden Looper | 528 | 620 | -92 |
| 2005-08-27 | vs NYN | 128 | W 2-1 | 56-72 | 4 | 42,180 | Jason Schmidt | Tom Glavine | Jason Schmidt | Tom Glavine | Armando Benitez | 530 | 621 | -91 |
| 2005-08-28 | vs NYN | 129 | W 4-1 | 57-72 | 4 | 41,659 | Noah Lowry | Kris Benson | Noah Lowry | Kris Benson | Armando Benitez | 534 | 622 | -88 |
| 2005-08-29 | vs COL | 130 | L 1-2 | 57-73 | 4 | 36,433 | Matt Cain | Byung-Hyun Kim | Byung-Hyun Kim | Matt Cain | Brian Fuentes | 535 | 624 | -89 |
| 2005-08-30 | vs COL | 131 | W 4-3 | 58-73 | 4 | 36,439 | Brad Hennessey | Aaron Cook | Jack Taschner | Mike DeJean | Armando Benitez | 539 | 627 | -88 |
| 2005-08-31 | vs COL | 132 | W 5-3 | 59-73 | 4 | 36,508 | Kevin Correia | Jeff Francis | Jeff Fassero | Jeff Francis | Armando Benitez | 544 | 630 | -86 |
| 2005-09-02 | @ ARI | 133 | W 6-3 | 60-73 | 3 | 19,961 | Jason Schmidt | Brandon Webb | Jason Schmidt | Brandon Webb | Armando Benitez | 550 | 633 | -83 |
| 2005-09-03 | @ ARI | 134 | W 9-4 | 61-73 | 2 | 29,670 | Noah Lowry | Claudio Vargas | Noah Lowry | Claudio Vargas | | 559 | 637 | -78 |
| 2005-09-04 | @ ARI | 135 | W 3-2 | 62-73 | 2 | 26,728 | Matt Cain | Russ Ortiz | Matt Cain | Russ Ortiz | Armando Benitez | 562 | 639 | -77 |
| 2005-09-05 | @ LAN | 136 | W 3-1 | 63-73 | 2 | 34,871 | Brad Hennessey | Derek Lowe | LaTroy Hawkins | Yhency Brazoban | Armando Benitez | 565 | 640 | -75 |
| 2005-09-06 | @ LAN | 137 | L 2-4 | 63-74 | 2 | 34,575 | Brett Tomko | Brad Penny | Yhency Brazoban | Jeremy Accardo | | 567 | 644 | -77 |
| 2005-09-07 | @ LAN | 138 | L 8-9 | 63-75 | 2 | 36,088 | Jason Schmidt | Jeff Weaver | Yhency Brazoban | Armando Benitez | | 575 | 653 | -78 |
| 2005-09-08 | vs CHN | 139 | L 3-5 | 63-76 | 3 | 37,042 | Noah Lowry | Carlos Zambrano | Carlos Zambrano | Noah Lowry | Ryan Dempster | 578 | 658 | -80 |
| 2005-09-09 | vs CHN | 140 | W 2-1 | 64-76 | 2 | 39,936 | Matt Cain | Jerome Williams | Matt Cain | Jerome Williams | | 580 | 659 | -79 |
| 2005-09-10 | vs CHN | 141 | L 2-5 | 64-77 | 4 | 42,013 | Brad Hennessey | Mark Prior | Mark Prior | Brad Hennessey | Ryan Dempster | 582 | 664 | -82 |
| 2005-09-11 | vs CHN | 142 | L 2-3 | 64-78 | 4 | 41,052 | Brett Tomko | Glendon Rusch | Michael Wuertz | LaTroy Hawkins | Ryan Dempster | 584 | 667 | -83 |
| 2005-09-12 | vs SDN | 143 | W 4-3 | 65-78 | 3 | 39,095 | Kevin Correia | Adam Eaton | Matt Kinney | Adam Eaton | Armando Benitez | 588 | 670 | -82 |
| 2005-09-13 | vs SDN | 144 | W 5-4 | 66-78 | 3 | 37,216 | Noah Lowry | Brian Lawrence | Noah Lowry | Brian Lawrence | Armando Benitez | 593 | 674 | -81 |
| 2005-09-14 | vs SDN | 145 | L 4-5 | 66-79 | 3 | 38,477 | Matt Cain | Woody Williams | Rudy Seanez | LaTroy Hawkins | Trevor Hoffman | 597 | 679 | -82 |
| 2005-09-15 | vs LAN | 146 | L 1-7 | 66-80 | 3 | 39,820 | Brad Hennessey | Derek Lowe | Derek Lowe | Brad Hennessey | | 598 | 686 | -88 |
| 2005-09-16 | vs LAN | 147 | W 5-4 | 67-80 | 3 | 42,962 | Brett Tomko | Brad Penny | Armando Benitez | Duaner Sanchez | | 603 | 690 | -87 |
| 2005-09-17 | vs LAN | 148 | W 2-1 | 68-80 | 2 | 42,864 | Jason Schmidt | Jeff Weaver | Tyler Walker | Jeff Weaver | Armando Benitez | 605 | 691 | -86 |
| 2005-09-18 | vs LAN | 149 | W 5-3 | 69-80 | 2 | 42,659 | Noah Lowry | Elmer Dessens | Matt Kinney | Franquelis Osoria | Armando Benitez | 610 | 694 | -84 |
| 2005-09-20 | @ WAS | 150 | W 4-3 | 70-80 | 2 | 32,403 | Matt Cain | Livan Hernandez | Jack Taschner | Livan Hernandez | Armando Benitez | 614 | 697 | -83 |
| 2005-09-21 | @ WAS | 151 | W 5-1 | 71-80 | 2 | 32,076 | Brad Hennessey | John Patterson | Brad Hennessey | John Patterson | Armando Benitez | 619 | 698 | -79 |
| 2005-09-22 | @ WAS | 152 | L 0-2 | 71-81 | 2 | 29,807 | Brett Tomko | Hector Carrasco | Jon Rauch | Brett Tomko | Chad Cordero | 619 | 700 | -81 |
| 2005-09-23 | @ COL | 153 | W 7-6 | 72-81 | 2 | 35,265 | Matt Kinney | Jeff Francis | Jeremy Accardo | Mike DeJean | Tyler Walker | 626 | 706 | -80 |
| 2005-09-24 | @ COL | 154 | L 0-6 | 72-82 | 2 | 25,141 | Noah Lowry | Sun-Woo Kim | Sun-Woo Kim | Noah Lowry | | 626 | 712 | -86 |
| 2005-09-25 | @ COL | 155 | W 6-2 | 73-82 | 2 | 31,746 | Matt Cain | Byung-Hyun Kim | Tyler Walker | Brian Fuentes | | 632 | 714 | -82 |
| 2005-09-26 | @ SDN | 156 | W 3-2 | 74-82 | 2 | 31,569 | Brad Hennessey | Jake Peavy | Tyler Walker | Trevor Hoffman | Armando Benitez | 635 | 716 | -81 |
| 2005-09-27 | @ SDN | 157 | L 6-9 | 74-83 | 2 | 29,492 | Brett Tomko | Adam Eaton | Clay Hensley | Jeff Fassero | Trevor Hoffman | 641 | 725 | -84 |
| 2005-09-28 | @ SDN | 158 | L 1-9 | 74-84 | 3 | 33,992 | Jason Schmidt | Pedro Astacio | Pedro Astacio | Jason Schmidt | | 642 | 734 | -92 |
| 2005-09-29 | @ SDN | 159 | L 0-1 | 74-85 | 3 | 29,818 | Noah Lowry | Brian Lawrence | Scott Cassidy | Jeremy Accardo | | 642 | 735 | -93 |
| 2005-09-30 | vs ARI | 160 | L 3-7 | 74-86 | 3 | 38,893 | Matt Cain | Claudio Vargas | Oscar Villarreal | LaTroy Hawkins | Jose Valverde | 645 | 742 | -97 |
| 2005-10-01 | vs ARI | 161 | L 1-2 | 74-87 | 3 | 38,772 | Brad Hennessey | Javier Vazquez | Brandon Medders | Armando Benitez | Jose Valverde | 646 | 744 | -98 |
| 2005-10-02 | vs ARI | 162 | W 3-1 | 75-87 | 3 | 40,239 | Brett Tomko | Brandon Webb | Brett Tomko | Brandon Webb | | 649 | 745 | -96 |