| 2005-04-04 | @ BAL | 1 | L 0-4 | 0-1 | 2 | 48,271 | Barry Zito | Rodrigo Lopez | Rodrigo Lopez | Barry Zito | | 0 | 4 | -4 |
| 2005-04-06 | @ BAL | 2 | W 9-0 | 1-1 | 1 | 22,415 | Kirk Saarloos | Daniel Cabrera | Kirk Saarloos | Daniel Cabrera | | 9 | 4 | 5 |
| 2005-04-07 | @ BAL | 3 | W 5-1 | 2-1 | 1 | 16,395 | Dan Haren | Erik Bedard | Ricardo Rincon | Steve Kline | | 14 | 5 | 9 |
| 2005-04-08 | @ TBA | 4 | L 2-3 | 2-2 | 1 | 10,223 | Joe Blanton | Rob Bell | Danys Baez | Juan Cruz | | 16 | 8 | 8 |
| 2005-04-09 | @ TBA | 5 | L 2-11 | 2-3 | 2 | 13,536 | Barry Zito | Hideo Nomo | Hideo Nomo | Barry Zito | | 18 | 19 | -1 |
| 2005-04-10 | @ TBA | 6 | W 6-1 | 3-3 | 1 | 12,174 | Rich Harden | Dewon Brazelton | Rich Harden | Dewon Brazelton | | 24 | 20 | 4 |
| 2005-04-11 | vs TOR | 7 | L 3-10 | 3-4 | 2 | 44,815 | Kirk Saarloos | Gustavo Chacin | Gustavo Chacin | Kirk Saarloos | | 27 | 30 | -3 |
| 2005-04-12 | vs TOR | 8 | L 2-5 | 3-5 | 3 | 10,106 | Dan Haren | Josh Towers | Josh Towers | Dan Haren | Miguel Batista | 29 | 35 | -6 |
| 2005-04-13 | vs TOR | 9 | W 6-3 | 4-5 | 3 | 15,860 | Joe Blanton | David Bush | Kiko Calero | Jason Frasor | | 35 | 38 | -3 |
| 2005-04-15 | vs ANA | 10 | L 1-6 | 4-6 | 4 | 23,283 | Barry Zito | Bartolo Colon | Bartolo Colon | Barry Zito | | 36 | 44 | -8 |
| 2005-04-16 | vs ANA | 11 | W 1-0 | 5-6 | 2 | 25,280 | Rich Harden | Jarrod Washburn | Kiko Calero | Scot Shields | | 37 | 44 | -7 |
| 2005-04-17 | vs ANA | 12 | W 7-6 | 6-6 | 1 | 36,291 | Kirk Saarloos | John Lackey | Huston Street | John Lackey | Octavio Dotel | 44 | 50 | -6 |
| 2005-04-18 | @ TEX | 13 | W 8-5 | 7-6 | 1 | 20,939 | Dan Haren | Chan Ho Park | Dan Haren | Chan Ho Park | Octavio Dotel | 52 | 55 | -3 |
| 2005-04-19 | @ TEX | 14 | L 0-3 | 7-7 | 1 | 22,146 | Joe Blanton | Pedro Astacio | Pedro Astacio | Joe Blanton | Francisco Cordero | 52 | 58 | -6 |
| 2005-04-20 | @ SEA | 15 | L 6-7 | 7-8 | 4 | 24,841 | Barry Zito | Joel Pineiro | Joel Pineiro | Huston Street | Eddie Guardado | 58 | 65 | -7 |
| 2005-04-21 | @ SEA | 16 | W 3-0 | 8-8 | 2 | 22,428 | Rich Harden | Ryan Franklin | Rich Harden | Ryan Franklin | Octavio Dotel | 61 | 65 | -4 |
| 2005-04-22 | @ ANA | 17 | W 4-3 | 9-8 | 1 | 43,810 | Kirk Saarloos | John Lackey | Keiichi Yabu | Francisco Rodriguez | Octavio Dotel | 65 | 68 | -3 |
| 2005-04-23 | @ ANA | 18 | L 5-9 | 9-9 | 3 | 43,880 | Dan Haren | Paul Byrd | Jake Woods | Dan Haren | | 70 | 77 | -7 |
| 2005-04-24 | @ ANA | 19 | L 0-1 | 9-10 | 3 | 43,915 | Joe Blanton | Kelvim Escobar | Scot Shields | Joe Blanton | Francisco Rodriguez | 70 | 78 | -8 |
| 2005-04-25 | vs CHA | 20 | L 0-6 | 9-11 | 4 | 10,206 | Barry Zito | Jon Garland | Jon Garland | Barry Zito | | 70 | 84 | -14 |
| 2005-04-26 | vs CHA | 21 | W 9-7 | 10-11 | 3 | 20,412 | Rich Harden | Mark Buehrle | Justin Duchscherer | Damaso Marte | Octavio Dotel | 79 | 91 | -12 |
| 2005-04-27 | vs CHA | 22 | W 2-1 | 11-11 | 2 | 14,172 | Kirk Saarloos | Freddy Garcia | Justin Duchscherer | Damaso Marte | | 81 | 92 | -11 |
| 2005-04-29 | vs SEA | 23 | L 2-4 | 11-12 | 4 | 18,545 | Dan Haren | Aaron Sele | Aaron Sele | Dan Haren | Eddie Guardado | 83 | 96 | -13 |
| 2005-04-30 | vs SEA | 24 | W 6-5 | 12-12 | 2 | 23,288 | Joe Blanton | Jamie Moyer | Keiichi Yabu | Ron Villone | | 89 | 101 | -12 |
| 2005-05-01 | vs SEA | 25 | W 3-2 | 13-12 | 2 | 30,634 | Barry Zito | Joel Pineiro | Barry Zito | Joel Pineiro | Octavio Dotel | 92 | 103 | -11 |
| 2005-05-02 | vs TEX | 26 | L 2-3 | 13-13 | 2 | 10,144 | Rich Harden | Kenny Rogers | Kenny Rogers | Rich Harden | Francisco Cordero | 94 | 106 | -12 |
| 2005-05-03 | vs TEX | 27 | L 1-6 | 13-14 | 3 | 10,427 | Kirk Saarloos | Chris Young | Chris Young | Kirk Saarloos | | 95 | 112 | -17 |
| 2005-05-04 | vs TEX | 28 | L 7-16 | 13-15 | 3 | 15,654 | Dan Haren | Chan Ho Park | Brian Shouse | Dan Haren | | 102 | 128 | -26 |
| 2005-05-06 | @ NYA | 29 | W 6-3 | 14-15 | 3 | 47,973 | Barry Zito | Carl Pavano | Octavio Dotel | Mariano Rivera | Kiko Calero | 108 | 131 | -23 |
| 2005-05-07 | @ NYA | 30 | L 0-5 | 14-16 | 3 | 52,776 | Joe Blanton | Mike Mussina | Mike Mussina | Joe Blanton | | 108 | 136 | -28 |
| 2005-05-08 | @ NYA | 31 | L 0-6 | 14-17 | 3 | 47,575 | Rich Harden | Kevin Brown | Kevin Brown | Rich Harden | | 108 | 142 | -34 |
| 2005-05-09 | @ BOS | 32 | L 5-13 | 14-18 | 3 | 35,000 | Dan Haren | Tim Wakefield | Tim Wakefield | Dan Haren | | 113 | 155 | -42 |
| 2005-05-10 | @ BOS | 33 | L 2-3 | 14-19 | 3 | 35,644 | Kirk Saarloos | Bronson Arroyo | Matt Mantei | Octavio Dotel | | 115 | 158 | -43 |
| 2005-05-11 | @ BOS | 34 | L 5-6 | 14-20 | 3 | 35,375 | Barry Zito | Matt Clement | Keith Foulke | Octavio Dotel | | 120 | 164 | -44 |
| 2005-05-13 | vs NYA | 35 | L 4-9 | 14-21 | 3 | 38,636 | Rich Harden | Mike Mussina | Mike Mussina | Rich Harden | | 124 | 173 | -49 |
| 2005-05-14 | vs NYA | 36 | L 6-15 | 14-22 | 3 | 41,180 | Joe Blanton | Kevin Brown | Kevin Brown | Joe Blanton | | 130 | 188 | -58 |
| 2005-05-15 | vs NYA | 37 | L 4-6 | 14-23 | 4 | 37,237 | Dan Haren | Randy Johnson | Randy Johnson | Ricardo Rincon | Mariano Rivera | 134 | 194 | -60 |
| 2005-05-16 | vs BOS | 38 | W 6-4 | 15-23 | 3 | 30,281 | Kirk Saarloos | Bronson Arroyo | Keiichi Yabu | Mike Myers | Octavio Dotel | 140 | 198 | -58 |
| 2005-05-17 | vs BOS | 39 | L 5-7 | 15-24 | 3 | 29,494 | Barry Zito | Matt Clement | Alan Embree | Juan Cruz | Keith Foulke | 145 | 205 | -60 |
| 2005-05-18 | vs BOS | 40 | W 13-6 | 16-24 | 3 | 42,705 | Seth Etherton | David Wells | Seth Etherton | David Wells | | 158 | 211 | -53 |
| 2005-05-20 | @ SFN | 41 | W 8-4 | 17-24 | 3 | 42,701 | Joe Blanton | Kirk Rueter | Keiichi Yabu | Kirk Rueter | | 166 | 215 | -49 |
| 2005-05-21 | @ SFN | 42 | L 2-3 | 17-25 | 3 | 43,069 | Dan Haren | Jeff Fassero | Jeff Fassero | Dan Haren | Tyler Walker | 168 | 218 | -50 |
| 2005-05-22 | @ SFN | 43 | L 1-3 | 17-26 | 4 | 42,452 | Barry Zito | Noah Lowry | Noah Lowry | Barry Zito | Tyler Walker | 169 | 221 | -52 |
| 2005-05-24 | @ TBA | 44 | L 4-5 | 17-27 | 4 | 8,801 | Seth Etherton | Doug Waechter | Travis Harper | Kirk Saarloos | Danys Baez | 173 | 226 | -53 |
| 2005-05-25 | @ TBA | 45 | L 6-14 | 17-28 | 4 | 8,785 | Joe Blanton | Scott Kazmir | Scott Kazmir | Joe Blanton | | 179 | 240 | -61 |
| 2005-05-26 | @ TBA | 46 | L 1-2 | 17-29 | 4 | 8,847 | Dan Haren | Hideo Nomo | Hideo Nomo | Dan Haren | Danys Baez | 180 | 242 | -62 |
| 2005-05-27 | @ CLE | 47 | L 1-4 | 17-30 | 4 | 19,711 | Barry Zito | Cliff Lee | Cliff Lee | Barry Zito | David Riske | 181 | 246 | -65 |
| 2005-05-28 | @ CLE | 48 | L 3-6 | 17-31 | 4 | 33,646 | Kirk Saarloos | Scott Elarton | Scott Elarton | Kirk Saarloos | Bob Howry | 184 | 252 | -68 |
| 2005-05-29 | @ CLE | 49 | L 2-6 | 17-32 | 4 | 25,737 | Seth Etherton | Jake Westbrook | Jake Westbrook | Seth Etherton | Matt Miller | 186 | 258 | -72 |
| 2005-05-30 | vs TBA | 50 | W 5-4 | 18-32 | 4 | 25,921 | Joe Blanton | Scott Kazmir | Huston Street | Travis Harper | | 191 | 262 | -71 |
| 2005-05-31 | vs TBA | 51 | W 10-1 | 19-32 | 4 | 11,702 | Dan Haren | Hideo Nomo | Dan Haren | Hideo Nomo | | 201 | 263 | -62 |
| 2005-06-01 | vs TBA | 52 | W 11-2 | 20-32 | 4 | 16,246 | Barry Zito | Mark Hendrickson | Barry Zito | Mark Hendrickson | | 212 | 265 | -53 |
| 2005-06-02 | vs TOR | 53 | W 5-3 | 21-32 | 4 | 10,637 | Kirk Saarloos | Josh Towers | Kirk Saarloos | Josh Towers | Huston Street | 217 | 268 | -51 |
| 2005-06-03 | vs TOR | 54 | L 2-6 | 21-33 | 4 | 12,332 | Ryan Glynn | Roy Halladay | Roy Halladay | Ryan Glynn | | 219 | 274 | -55 |
| 2005-06-04 | vs TOR | 55 | W 5-2 | 22-33 | 4 | 25,273 | Joe Blanton | Ted Lilly | Joe Blanton | Ted Lilly | Huston Street | 224 | 276 | -52 |
| 2005-06-05 | vs TOR | 56 | W 12-4 | 23-33 | 4 | 28,754 | Dan Haren | Chad Gaudin | Dan Haren | Chad Gaudin | | 236 | 280 | -44 |
| 2005-06-07 | @ WAS | 57 | L 1-2 | 23-34 | 4 | 26,879 | Barry Zito | Tony Armas | Tony Armas | Barry Zito | Chad Cordero | 237 | 282 | -45 |
| 2005-06-08 | @ WAS | 58 | L 2-7 | 23-35 | 4 | 28,749 | Ryan Glynn | Esteban Loaiza | Esteban Loaiza | Ryan Glynn | | 239 | 289 | -50 |
| 2005-06-09 | @ WAS | 59 | L 3-4 | 23-36 | 4 | 26,672 | Joe Blanton | Livan Hernandez | Livan Hernandez | Joe Blanton | Chad Cordero | 242 | 293 | -51 |
| 2005-06-10 | @ ATL | 60 | W 6-4 | 24-36 | 4 | 28,535 | Dan Haren | Kyle Davies | Dan Haren | Roman Colon | Huston Street | 248 | 297 | -49 |
| 2005-06-11 | @ ATL | 61 | L 3-5 | 24-37 | 4 | 36,004 | Kirk Saarloos | John Smoltz | John Smoltz | Justin Duchscherer | | 251 | 302 | -51 |
| 2005-06-12 | @ ATL | 62 | W 11-5 | 25-37 | 4 | 27,819 | Barry Zito | Horacio Ramirez | Barry Zito | Blaine Boyer | | 262 | 307 | -45 |
| 2005-06-14 | vs NYN | 63 | W 5-0 | 26-37 | 4 | 18,744 | Joe Blanton | Tom Glavine | Joe Blanton | Tom Glavine | Huston Street | 267 | 307 | -40 |
| 2005-06-15 | vs NYN | 64 | W 3-2 | 27-37 | 4 | 27,598 | Dan Haren | Victor Zambrano | Justin Duchscherer | Royce Ring | | 270 | 309 | -39 |
| 2005-06-16 | vs NYN | 65 | L 6-9 | 27-38 | 4 | 17,308 | Ryan Glynn | Kris Benson | Kris Benson | Ryan Glynn | Braden Looper | 276 | 318 | -42 |
| 2005-06-17 | vs PHI | 66 | L 1-6 | 27-39 | 4 | 15,601 | Barry Zito | Rob Tejeda | Rob Tejeda | Barry Zito | | 277 | 324 | -47 |
| 2005-06-18 | vs PHI | 67 | W 2-1 | 28-39 | 4 | 20,332 | Kirk Saarloos | Cory Lidle | Kirk Saarloos | Cory Lidle | Justin Duchscherer | 279 | 325 | -46 |
| 2005-06-19 | vs PHI | 68 | W 5-2 | 29-39 | 4 | 30,619 | Joe Blanton | Jon Lieber | Joe Blanton | Jon Lieber | Justin Duchscherer | 284 | 327 | -43 |
| 2005-06-20 | @ SEA | 69 | W 6-2 | 30-39 | 4 | 27,263 | Dan Haren | Aaron Sele | Dan Haren | Ron Villone | | 290 | 329 | -39 |
| 2005-06-21 | @ SEA | 70 | W 4-2 | 31-39 | 4 | 31,673 | Rich Harden | Joel Pineiro | Rich Harden | Joel Pineiro | Justin Duchscherer | 294 | 331 | -37 |
| 2005-06-22 | @ SEA | 71 | L 4-5 | 31-40 | 4 | 28,829 | Barry Zito | Jamie Moyer | Eddie Guardado | Ryan Glynn | | 298 | 336 | -38 |
| 2005-06-23 | @ SEA | 72 | W 5-0 | 32-40 | 4 | 37,549 | Kirk Saarloos | Ryan Franklin | Kirk Saarloos | Ryan Franklin | | 303 | 336 | -33 |
| 2005-06-24 | vs SFN | 73 | W 4-3 | 33-40 | 4 | 40,485 | Joe Blanton | Jeff Fassero | Joe Blanton | Jeff Fassero | Justin Duchscherer | 307 | 339 | -32 |
| 2005-06-25 | vs SFN | 74 | W 6-3 | 34-40 | 3 | 46,763 | Dan Haren | Noah Lowry | Dan Haren | Noah Lowry | | 313 | 342 | -29 |
| 2005-06-26 | vs SFN | 75 | W 16-0 | 35-40 | 3 | 44,633 | Rich Harden | Brett Tomko | Rich Harden | Brett Tomko | | 329 | 342 | -13 |
| 2005-06-28 | vs SEA | 76 | W 8-1 | 36-40 | 3 | 14,384 | Barry Zito | Jamie Moyer | Barry Zito | Jamie Moyer | | 337 | 343 | -6 |
| 2005-06-29 | vs SEA | 77 | W 6-2 | 37-40 | 3 | 25,177 | Joe Blanton | Ryan Franklin | Joe Blanton | Ryan Franklin | | 343 | 345 | -2 |
| 2005-06-30 | vs SEA | 78 | W 6-2 | 38-40 | 3 | 19,583 | Dan Haren | Gil Meche | Dan Haren | Gil Meche | | 349 | 347 | 2 |
| 2005-07-01 | vs CHA | 79 | W 6-2 | 39-40 | 3 | 15,293 | Rich Harden | Jose Contreras | Rich Harden | Jose Contreras | | 355 | 349 | 6 |
| 2005-07-02 | vs CHA | 80 | L 3-5 | 39-41 | 3 | 45,712 | Kirk Saarloos | Jon Garland | Jon Garland | Kirk Saarloos | Dustin Hermanson | 358 | 354 | 4 |
| 2005-07-03 | vs CHA | 81 | W 7-2 | 40-41 | 3 | 22,596 | Barry Zito | Mark Buehrle | Barry Zito | Mark Buehrle | | 365 | 356 | 9 |
| 2005-07-05 | @ TOR | 82 | W 10-7 | 41-41 | 3 | 21,667 | Dan Haren | Josh Towers | Justin Duchscherer | Miguel Batista | | 375 | 363 | 12 |
| 2005-07-06 | @ TOR | 83 | L 0-8 | 41-42 | 3 | 21,208 | Joe Blanton | Ted Lilly | Ted Lilly | Joe Blanton | | 375 | 371 | 4 |
| 2005-07-07 | @ TOR | 84 | L 2-4 | 41-43 | 3 | 22,339 | Rich Harden | Gustavo Chacin | Gustavo Chacin | Rich Harden | Miguel Batista | 377 | 375 | 2 |
| 2005-07-08 | @ CHA | 85 | W 4-2 | 42-43 | 3 | 33,623 | Kirk Saarloos | Jon Garland | Kirk Saarloos | Jon Garland | Huston Street | 381 | 377 | 4 |
| 2005-07-09 | @ CHA | 86 | W 10-1 | 43-43 | 3 | 38,318 | Barry Zito | Mark Buehrle | Barry Zito | Mark Buehrle | | 391 | 378 | 13 |
| 2005-07-10 | @ CHA | 87 | W 9-8 | 44-43 | 3 | 33,221 | Dan Haren | Freddy Garcia | Huston Street | Luis Vizcaino | | 400 | 386 | 14 |
| 2005-07-14 | vs TEX | 88 | W 6-0 | 45-43 | 3 | 17,987 | Rich Harden | Chan Ho Park | Rich Harden | Chan Ho Park | | 406 | 386 | 20 |
| 2005-07-15 | vs TEX | 89 | W 7-2 | 46-43 | 3 | 22,423 | Barry Zito | John Wasdin | Barry Zito | John Wasdin | | 413 | 388 | 25 |
| 2005-07-16 | vs TEX | 90 | L 8-10 | 46-44 | 3 | 22,826 | Joe Blanton | Kenny Rogers | Kenny Rogers | Joe Blanton | Francisco Cordero | 421 | 398 | 23 |
| 2005-07-17 | vs TEX | 91 | W 5-4 | 47-44 | 3 | 25,330 | Dan Haren | Chris Young | Joe Kennedy | Kameron Loe | | 426 | 402 | 24 |
| 2005-07-18 | @ ANA | 92 | L 2-5 | 47-45 | 3 | 40,546 | Kirk Saarloos | Ervin Santana | Ervin Santana | Kirk Saarloos | Francisco Rodriguez | 428 | 407 | 21 |
| 2005-07-19 | @ ANA | 93 | W 3-1 | 48-45 | 3 | 42,155 | Rich Harden | Jarrod Washburn | Rich Harden | Jarrod Washburn | Huston Street | 431 | 408 | 23 |
| 2005-07-20 | @ ANA | 94 | W 3-0 | 49-45 | 2 | 42,285 | Barry Zito | Paul Byrd | Barry Zito | Paul Byrd | Huston Street | 434 | 408 | 26 |
| 2005-07-21 | @ TEX | 95 | W 6-4 | 50-45 | 2 | 31,643 | Joe Blanton | Kenny Rogers | Jay Witasick | Kameron Loe | Huston Street | 440 | 412 | 28 |
| 2005-07-22 | @ TEX | 96 | W 11-10 | 51-45 | 2 | 35,266 | Dan Haren | Chris Young | Dan Haren | Chris Young | Justin Duchscherer | 451 | 422 | 29 |
| 2005-07-23 | @ TEX | 97 | W 5-4 | 52-45 | 2 | 38,841 | Kirk Saarloos | Ricardo Rodriguez | Kirk Saarloos | Ricardo Rodriguez | Huston Street | 456 | 426 | 30 |
| 2005-07-24 | @ TEX | 98 | W 8-3 | 53-45 | 2 | 29,410 | Rich Harden | Chan Ho Park | Rich Harden | Chan Ho Park | | 464 | 429 | 35 |
| 2005-07-25 | vs CLE | 99 | W 13-4 | 54-45 | 2 | 19,242 | Barry Zito | CC Sabathia | Barry Zito | CC Sabathia | Keiichi Yabu | 477 | 433 | 44 |
| 2005-07-26 | vs CLE | 100 | L 0-2 | 54-46 | 2 | 18,606 | Joe Blanton | Jake Westbrook | Jake Westbrook | Joe Blanton | Bob Wickman | 477 | 435 | 42 |
| 2005-07-27 | vs CLE | 101 | W 5-4 | 55-46 | 2 | 40,331 | Dan Haren | Scott Elarton | Huston Street | David Riske | | 482 | 439 | 43 |
| 2005-07-29 | vs DET | 102 | W 8-4 | 56-46 | 2 | 20,563 | Rich Harden | Sean Douglass | Rich Harden | Sean Douglass | | 490 | 443 | 47 |
| 2005-07-30 | vs DET | 103 | W 9-5 | 57-46 | 2 | 25,265 | Barry Zito | Nate Robertson | Barry Zito | Nate Robertson | Jay Witasick | 499 | 448 | 51 |
| 2005-07-31 | vs DET | 104 | W 5-2 | 58-46 | 2 | 30,057 | Kirk Saarloos | Jeremy Bonderman | Kirk Saarloos | Jeremy Bonderman | | 504 | 450 | 54 |
| 2005-08-01 | @ MIN | 105 | W 2-1 | 59-46 | 2 | 21,176 | Joe Blanton | Johan Santana | Joe Blanton | Johan Santana | Huston Street | 506 | 451 | 55 |
| 2005-08-02 | @ MIN | 106 | W 5-2 | 60-46 | 2 | 22,101 | Dan Haren | Joe Mays | Dan Haren | J.C. Romero | Huston Street | 511 | 453 | 58 |
| 2005-08-03 | @ MIN | 107 | L 3-4 | 60-47 | 2 | 30,581 | Rich Harden | Carlos Silva | Joe Nathan | Justin Duchscherer | | 514 | 457 | 57 |
| 2005-08-04 | @ MIN | 108 | W 5-2 | 61-47 | 2 | 25,154 | Barry Zito | Kyle Lohse | Barry Zito | Jesse Crain | Huston Street | 519 | 459 | 60 |
| 2005-08-05 | @ KCA | 109 | W 5-4 | 62-47 | 2 | 23,979 | Kirk Saarloos | Zack Greinke | Joe Kennedy | Jeremy Affeldt | Huston Street | 524 | 463 | 61 |
| 2005-08-06 | @ KCA | 110 | W 16-1 | 63-47 | 1 | 19,964 | Joe Blanton | Jose Lima | Joe Blanton | Jose Lima | | 540 | 464 | 76 |
| 2005-08-07 | @ KCA | 111 | W 11-0 | 64-47 | 1 | 15,228 | Dan Haren | Runelvys Hernandez | Dan Haren | Runelvys Hernandez | | 551 | 464 | 87 |
| 2005-08-09 | vs ANA | 112 | L 2-9 | 64-48 | 2 | 40,774 | Rich Harden | John Lackey | John Lackey | Rich Harden | | 553 | 473 | 80 |
| 2005-08-10 | vs ANA | 113 | W 4-3 | 65-48 | 1 | 45,131 | Barry Zito | Ervin Santana | Justin Duchscherer | Scot Shields | Huston Street | 557 | 476 | 81 |
| 2005-08-11 | vs ANA | 114 | W 5-4 | 66-48 | 1 | 31,471 | Joe Blanton | Paul Byrd | Justin Duchscherer | Scot Shields | | 562 | 480 | 82 |
| 2005-08-12 | vs MIN | 115 | L 0-1 | 66-49 | 1 | 46,812 | Dan Haren | Johan Santana | Johan Santana | Dan Haren | | 562 | 481 | 81 |
| 2005-08-13 | vs MIN | 116 | W 5-2 | 67-49 | 1 | 47,385 | Kirk Saarloos | Joe Mays | Kirk Saarloos | Joe Mays | Huston Street | 567 | 483 | 84 |
| 2005-08-14 | vs MIN | 117 | L 1-2 | 67-50 | 2 | 29,067 | Rich Harden | Carlos Silva | Juan Rincon | Justin Duchscherer | Joe Nathan | 568 | 485 | 83 |
| 2005-08-15 | vs BAL | 118 | L 2-6 | 67-51 | 2 | 20,285 | Barry Zito | Rodrigo Lopez | Rodrigo Lopez | Barry Zito | | 570 | 491 | 79 |
| 2005-08-16 | vs BAL | 119 | L 3-4 | 67-52 | 2 | 23,252 | Joe Blanton | Bruce Chen | Bruce Chen | Jay Witasick | B.J. Ryan | 573 | 495 | 78 |
| 2005-08-17 | vs BAL | 120 | L 3-5 | 67-53 | 2 | 32,290 | Dan Haren | Eric DuBose | Eric DuBose | Dan Haren | Todd Williams | 576 | 500 | 76 |
| 2005-08-19 | vs KCA | 121 | W 4-0 | 68-53 | 2 | 20,715 | Rich Harden | Jose Lima | Rich Harden | Jose Lima | Huston Street | 580 | 500 | 80 |
| 2005-08-20 | vs KCA | 122 | L 1-2 | 68-54 | 2 | 27,648 | Barry Zito | Mike Wood | Mike Wood | Barry Zito | Mike MacDougal | 581 | 502 | 79 |
| 2005-08-21 | vs KCA | 123 | L 4-5 | 68-55 | 2 | 25,834 | Joe Blanton | Runelvys Hernandez | Jimmy Gobble | Kiko Calero | | 585 | 507 | 78 |
| 2005-08-23 | @ DET | 124 | L 1-4 | 68-56 | 2 | 24,467 | Dan Haren | Nate Robertson | Nate Robertson | Dan Haren | Fernando Rodney | 586 | 511 | 75 |
| 2005-08-24 | @ DET | 125 | W 9-2 | 69-56 | 2 | 29,210 | Kirk Saarloos | Jeremy Bonderman | Kirk Saarloos | Jeremy Bonderman | | 595 | 513 | 82 |
| 2005-08-25 | @ DET | 126 | W 11-1 | 70-56 | 2 | 24,440 | Barry Zito | Mike Maroth | Barry Zito | Mike Maroth | | 606 | 514 | 92 |
| 2005-08-26 | @ BAL | 127 | W 4-1 | 71-56 | 2 | 26,105 | Joe Blanton | Bruce Chen | Joe Blanton | Bruce Chen | Huston Street | 610 | 515 | 95 |
| 2005-08-27 | @ BAL | 128 | W 12-3 | 72-56 | 2 | 33,195 | Joe Kennedy | Eric DuBose | Joe Kennedy | Eric DuBose | | 622 | 518 | 104 |
| 2005-08-28 | @ BAL | 129 | W 10-3 | 73-56 | 1 | 26,971 | Dan Haren | John Maine | Dan Haren | John Maine | | 632 | 521 | 111 |
| 2005-08-29 | @ BAL | 130 | W 10-5 | 74-56 | 1 | 18,287 | Kirk Saarloos | Erik Bedard | Kiko Calero | Jorge Julio | | 642 | 526 | 116 |
| 2005-08-30 | @ ANA | 131 | W 2-1 | 75-56 | 1 | 42,176 | Barry Zito | Bartolo Colon | Kiko Calero | Francisco Rodriguez | Huston Street | 644 | 527 | 117 |
| 2005-08-31 | @ ANA | 132 | L 1-2 | 75-57 | 1 | 43,501 | Joe Blanton | John Lackey | John Lackey | Joe Blanton | Francisco Rodriguez | 645 | 529 | 116 |
| 2005-09-01 | @ ANA | 133 | L 0-3 | 75-58 | 1 | 41,632 | Joe Kennedy | Ervin Santana | Ervin Santana | Joe Kennedy | Francisco Rodriguez | 645 | 532 | 113 |
| 2005-09-02 | vs NYA | 134 | W 12-0 | 76-58 | 1 | 36,048 | Dan Haren | Al Leiter | Dan Haren | Al Leiter | | 657 | 532 | 125 |
| 2005-09-03 | vs NYA | 135 | L 0-7 | 76-59 | 1 | 40,076 | Kirk Saarloos | Aaron Small | Aaron Small | Kirk Saarloos | | 657 | 539 | 118 |
| 2005-09-04 | vs NYA | 136 | L 3-7 | 76-60 | 2 | 43,874 | Barry Zito | Shawn Chacon | Shawn Chacon | Barry Zito | | 660 | 546 | 114 |
| 2005-09-05 | vs SEA | 137 | L 0-2 | 76-61 | 2 | 22,262 | Joe Blanton | Felix Hernandez | Felix Hernandez | Joe Blanton | Eddie Guardado | 660 | 548 | 112 |
| 2005-09-06 | vs SEA | 138 | L 2-3 | 76-62 | 2 | 24,012 | Joe Kennedy | Joel Pineiro | Joel Pineiro | Joe Kennedy | Eddie Guardado | 662 | 551 | 111 |
| 2005-09-07 | vs SEA | 139 | W 8-7 | 77-62 | 2 | 14,609 | Dan Haren | Ryan Franklin | Huston Street | Eddie Guardado | | 670 | 558 | 112 |
| 2005-09-09 | @ TEX | 140 | W 9-8 | 78-62 | 2 | 26,468 | Barry Zito | Juan Dominguez | Barry Zito | Juan Dominguez | Huston Street | 679 | 566 | 113 |
| 2005-09-10 | @ TEX | 141 | W 5-4 | 79-62 | 2 | 41,058 | Joe Blanton | Kameron Loe | Joe Blanton | Kameron Loe | Huston Street | 684 | 570 | 114 |
| 2005-09-11 | @ TEX | 142 | L 4-7 | 79-63 | 2 | 19,913 | Joe Kennedy | Kenny Rogers | Kenny Rogers | Joe Kennedy | John Wasdin | 688 | 577 | 111 |
| 2005-09-12 | @ CLE | 143 | W 2-0 | 80-63 | 2 | 20,282 | Dan Haren | CC Sabathia | Dan Haren | CC Sabathia | Huston Street | 690 | 577 | 113 |
| 2005-09-13 | @ CLE | 144 | L 2-5 | 80-64 | 2 | 21,564 | Kirk Saarloos | Kevin Millwood | Kevin Millwood | Justin Duchscherer | Bob Wickman | 692 | 582 | 110 |
| 2005-09-14 | @ CLE | 145 | L 4-6 | 80-65 | 2 | 21,920 | Barry Zito | Jake Westbrook | Jake Westbrook | Barry Zito | Bob Wickman | 696 | 588 | 108 |
| 2005-09-15 | @ BOS | 146 | W 6-2 | 81-65 | 1 | 35,079 | Joe Blanton | Curt Schilling | Joe Blanton | Curt Schilling | | 702 | 590 | 112 |
| 2005-09-16 | @ BOS | 147 | L 2-3 | 81-66 | 2 | 35,249 | Joe Kennedy | Tim Wakefield | Mike Timlin | Juan Cruz | | 704 | 593 | 111 |
| 2005-09-17 | @ BOS | 148 | L 1-2 | 81-67 | 2 | 35,220 | Dan Haren | Bronson Arroyo | Bronson Arroyo | Dan Haren | Mike Timlin | 705 | 595 | 110 |
| 2005-09-18 | @ BOS | 149 | W 12-3 | 82-67 | 2 | 34,849 | Kirk Saarloos | Matt Clement | Kirk Saarloos | Matt Clement | | 717 | 598 | 119 |
| 2005-09-19 | vs MIN | 150 | W 7-6 | 83-67 | 2 | 15,262 | Barry Zito | Brad Radke | Barry Zito | Brad Radke | | 724 | 604 | 120 |
| 2005-09-20 | vs MIN | 151 | W 8-3 | 84-67 | 2 | 18,014 | Joe Blanton | Francisco Liriano | Joe Blanton | Francisco Liriano | | 732 | 607 | 125 |
| 2005-09-21 | vs MIN | 152 | L 4-10 | 84-68 | 2 | 14,927 | Joe Kennedy | Scott Baker | Scott Baker | Joe Kennedy | | 736 | 617 | 119 |
| 2005-09-23 | vs TEX | 153 | L 1-3 | 84-69 | 2 | 33,402 | Dan Haren | Kenny Rogers | Kenny Rogers | Dan Haren | Francisco Cordero | 737 | 620 | 117 |
| 2005-09-24 | vs TEX | 154 | W 7-6 | 85-69 | 2 | 26,704 | Barry Zito | R.A. Dickey | Justin Duchscherer | John Wasdin | Huston Street | 744 | 626 | 118 |
| 2005-09-25 | vs TEX | 155 | L 2-6 | 85-70 | 2 | 27,709 | Kirk Saarloos | Juan Dominguez | Juan Dominguez | Kirk Saarloos | | 746 | 632 | 114 |
| 2005-09-26 | vs ANA | 156 | L 3-4 | 85-71 | 2 | 19,347 | Joe Blanton | John Lackey | John Lackey | Joe Blanton | Francisco Rodriguez | 749 | 636 | 113 |
| 2005-09-27 | vs ANA | 157 | L 3-4 | 85-72 | 2 | 18,416 | Joe Kennedy | Ervin Santana | Ervin Santana | Joe Kennedy | Francisco Rodriguez | 752 | 640 | 112 |
| 2005-09-28 | vs ANA | 158 | W 6-1 | 86-72 | 2 | 34,562 | Dan Haren | Paul Byrd | Dan Haren | Paul Byrd | | 758 | 641 | 117 |
| 2005-09-29 | vs ANA | 159 | L 1-7 | 86-73 | 2 | 21,957 | Barry Zito | Bartolo Colon | Bartolo Colon | Barry Zito | | 759 | 648 | 111 |
| 2005-09-30 | @ SEA | 160 | L 1-4 | 86-74 | 2 | 34,809 | Kirk Saarloos | Jamie Moyer | Jamie Moyer | Kirk Saarloos | Eddie Guardado | 760 | 652 | 108 |
| 2005-10-01 | @ SEA | 161 | W 4-3 | 87-74 | 2 | 26,998 | Joe Blanton | Jeff Harris | Joe Blanton | Julio Mateo | Huston Street | 764 | 655 | 109 |
| 2005-10-02 | @ SEA | 162 | W 8-3 | 88-74 | 2 | 35,300 | Joe Kennedy | Felix Hernandez | Joe Kennedy | George Sherrill | | 772 | 658 | 114 |