| 2005-04-03 | vs BOS | 1 | W 9-2 | 1-0 | 1 | 54,818 | Randy Johnson | David Wells | Randy Johnson | David Wells | | 9 | 2 | 7 |
| 2005-04-05 | vs BOS | 2 | W 4-3 | 2-0 | 2 | 54,690 | Carl Pavano | Matt Clement | Mariano Rivera | Keith Foulke | | 13 | 5 | 8 |
| 2005-04-06 | vs BOS | 3 | L 3-7 | 2-1 | 1 | 55,165 | Mike Mussina | Tim Wakefield | Mike Timlin | Mariano Rivera | | 16 | 12 | 4 |
| 2005-04-08 | vs BAL | 4 | L 5-12 | 2-2 | 3 | 43,128 | Jaret Wright | Sidney Ponson | Sidney Ponson | Jaret Wright | | 21 | 24 | -3 |
| 2005-04-09 | vs BAL | 5 | W 8-5 | 3-2 | 1 | 50,275 | Randy Johnson | Bruce Chen | Tanyon Sturtze | Steve Reed | Mariano Rivera | 29 | 29 | 0 |
| 2005-04-10 | vs BAL | 6 | L 2-7 | 3-3 | 3 | 46,797 | Carl Pavano | Rodrigo Lopez | Rodrigo Lopez | Carl Pavano | | 31 | 36 | -5 |
| 2005-04-11 | @ BOS | 7 | L 1-8 | 3-4 | 5 | 33,702 | Mike Mussina | Tim Wakefield | Tim Wakefield | Mike Mussina | | 32 | 44 | -12 |
| 2005-04-13 | @ BOS | 8 | W 5-2 | 4-4 | 3 | 35,115 | Jaret Wright | Curt Schilling | Jaret Wright | Curt Schilling | Mariano Rivera | 37 | 46 | -9 |
| 2005-04-14 | @ BOS | 9 | L 5-8 | 4-5 | 4 | 35,251 | Randy Johnson | Bronson Arroyo | Keith Foulke | Tom Gordon | | 42 | 54 | -12 |
| 2005-04-15 | @ BAL | 10 | L 1-8 | 4-6 | 4 | 48,061 | Carl Pavano | Bruce Chen | Bruce Chen | Carl Pavano | | 43 | 62 | -19 |
| 2005-04-16 | @ BAL | 11 | L 6-7 | 4-7 | 4 | 48,598 | Mike Mussina | Rodrigo Lopez | Steve Kline | Tom Gordon | B.J. Ryan | 49 | 69 | -20 |
| 2005-04-17 | @ BAL | 12 | L 4-8 | 4-8 | 4 | 47,883 | Kevin Brown | Daniel Cabrera | Daniel Cabrera | Kevin Brown | | 53 | 77 | -24 |
| 2005-04-18 | vs TBA | 13 | W 19-8 | 5-8 | 4 | 35,282 | Jaret Wright | Rob Bell | Jaret Wright | Rob Bell | | 72 | 85 | -13 |
| 2005-04-19 | vs TBA | 14 | L 2-6 | 5-9 | 4 | 45,802 | Randy Johnson | Hideo Nomo | Hideo Nomo | Randy Johnson | | 74 | 91 | -17 |
| 2005-04-20 | @ TOR | 15 | W 11-2 | 6-9 | 4 | 22,838 | Carl Pavano | Ted Lilly | Carl Pavano | Ted Lilly | | 85 | 93 | -8 |
| 2005-04-21 | @ TOR | 16 | W 4-3 | 7-9 | 4 | 23,178 | Mike Mussina | Gustavo Chacin | Mike Mussina | Gustavo Chacin | Mariano Rivera | 89 | 96 | -7 |
| 2005-04-22 | vs TEX | 17 | L 3-5 | 7-10 | 4 | 42,710 | Kevin Brown | Chris Young | Chris Young | Kevin Brown | Francisco Cordero | 92 | 101 | -9 |
| 2005-04-23 | vs TEX | 18 | L 2-10 | 7-11 | 5 | 44,731 | Jaret Wright | Chan Ho Park | Chan Ho Park | Jaret Wright | | 94 | 111 | -17 |
| 2005-04-24 | vs TEX | 19 | W 11-1 | 8-11 | 4 | 42,732 | Randy Johnson | Pedro Astacio | Randy Johnson | Pedro Astacio | | 105 | 112 | -7 |
| 2005-04-26 | vs ANA | 20 | W 12-4 | 9-11 | 4 | 36,328 | Carl Pavano | Bartolo Colon | Carl Pavano | Bartolo Colon | | 117 | 116 | 1 |
| 2005-04-27 | vs ANA | 21 | L 1-5 | 9-12 | 4 | 37,934 | Mike Mussina | Jarrod Washburn | Jarrod Washburn | Mike Mussina | | 118 | 121 | -3 |
| 2005-04-28 | vs ANA | 22 | L 1-3 | 9-13 | 4 | 51,951 | Kevin Brown | John Lackey | John Lackey | Kevin Brown | Francisco Rodriguez | 119 | 124 | -5 |
| 2005-04-29 | vs TOR | 23 | L 0-2 | 9-14 | 4 | 40,839 | Randy Johnson | Roy Halladay | Roy Halladay | Randy Johnson | | 119 | 126 | -7 |
| 2005-04-30 | vs TOR | 24 | W 4-3 | 10-14 | 4 | 47,483 | Chien-Ming Wang | David Bush | Mariano Rivera | Vinnie Chulk | | 123 | 129 | -6 |
| 2005-05-01 | vs TOR | 25 | L 6-8 | 10-15 | 4 | 54,224 | Carl Pavano | Ted Lilly | Pete Walker | Mike Stanton | Miguel Batista | 129 | 137 | -8 |
| 2005-05-02 | @ TBA | 26 | W 6-2 | 11-15 | 4 | 13,217 | Mike Mussina | Scott Kazmir | Mike Mussina | Scott Kazmir | | 135 | 139 | -4 |
| 2005-05-03 | @ TBA | 27 | L 4-11 | 11-16 | 4 | 14,824 | Kevin Brown | Doug Waechter | Doug Waechter | Kevin Brown | | 139 | 150 | -11 |
| 2005-05-04 | @ TBA | 28 | L 8-11 | 11-17 | 4 | 16,452 | Sean Henn | Hideo Nomo | Casey Fossum | Sean Henn | Danys Baez | 147 | 161 | -14 |
| 2005-05-05 | @ TBA | 29 | L 2-6 | 11-18 | 4 | 16,662 | Chien-Ming Wang | Mark Hendrickson | Mark Hendrickson | Chien-Ming Wang | | 149 | 167 | -18 |
| 2005-05-06 | vs OAK | 30 | L 3-6 | 11-19 | 4 | 47,973 | Carl Pavano | Barry Zito | Octavio Dotel | Mariano Rivera | Kiko Calero | 152 | 173 | -21 |
| 2005-05-07 | vs OAK | 31 | W 5-0 | 12-19 | 4 | 52,776 | Mike Mussina | Joe Blanton | Mike Mussina | Joe Blanton | | 157 | 173 | -16 |
| 2005-05-08 | vs OAK | 32 | W 6-0 | 13-19 | 4 | 47,575 | Kevin Brown | Rich Harden | Kevin Brown | Rich Harden | | 163 | 173 | -10 |
| 2005-05-09 | vs SEA | 33 | W 4-3 | 14-19 | 4 | 38,079 | Randy Johnson | Gil Meche | Randy Johnson | Jeff Nelson | Mariano Rivera | 167 | 176 | -9 |
| 2005-05-10 | vs SEA | 34 | W 7-4 | 15-19 | 4 | 39,780 | Chien-Ming Wang | Aaron Sele | Chien-Ming Wang | Aaron Sele | Mariano Rivera | 174 | 180 | -6 |
| 2005-05-11 | vs SEA | 35 | W 13-9 | 16-19 | 4 | 47,844 | Carl Pavano | Jamie Moyer | Paul Quantrill | Matt Thornton | | 187 | 189 | -2 |
| 2005-05-13 | @ OAK | 36 | W 9-4 | 17-19 | 4 | 38,636 | Mike Mussina | Rich Harden | Mike Mussina | Rich Harden | | 196 | 193 | 3 |
| 2005-05-14 | @ OAK | 37 | W 15-6 | 18-19 | 4 | 41,180 | Kevin Brown | Joe Blanton | Kevin Brown | Joe Blanton | | 211 | 199 | 12 |
| 2005-05-15 | @ OAK | 38 | W 6-4 | 19-19 | 4 | 37,237 | Randy Johnson | Dan Haren | Randy Johnson | Ricardo Rincon | Mariano Rivera | 217 | 203 | 14 |
| 2005-05-16 | @ SEA | 39 | W 6-3 | 20-19 | 4 | 37,814 | Chien-Ming Wang | Aaron Sele | Chien-Ming Wang | Shigetoshi Hasegawa | Mariano Rivera | 223 | 206 | 17 |
| 2005-05-17 | @ SEA | 40 | W 6-0 | 21-19 | 4 | 35,549 | Carl Pavano | Julio Mateo | Carl Pavano | Julio Mateo | | 229 | 206 | 23 |
| 2005-05-18 | @ SEA | 41 | L 6-7 | 21-20 | 4 | 37,419 | Mike Mussina | Jamie Moyer | Jeff Nelson | Tom Gordon | Ron Villone | 235 | 213 | 22 |
| 2005-05-20 | @ NYN | 42 | W 5-2 | 22-20 | 3 | 55,740 | Kevin Brown | Victor Zambrano | Kevin Brown | Victor Zambrano | Mariano Rivera | 240 | 215 | 25 |
| 2005-05-21 | @ NYN | 43 | L 1-7 | 22-21 | 4 | 55,800 | Randy Johnson | Kris Benson | Kris Benson | Randy Johnson | | 241 | 222 | 19 |
| 2005-05-22 | @ NYN | 44 | W 5-3 | 23-21 | 3 | 55,953 | Carl Pavano | Pedro Martinez | Carl Pavano | Roberto Hernandez | Mariano Rivera | 246 | 225 | 21 |
| 2005-05-24 | vs DET | 45 | W 12-3 | 24-21 | 3 | 37,099 | Mike Mussina | Wil Ledezma | Mike Mussina | Wil Ledezma | | 258 | 228 | 30 |
| 2005-05-25 | vs DET | 46 | W 4-2 | 25-21 | 3 | 51,833 | Chien-Ming Wang | Mike Maroth | Chien-Ming Wang | Mike Maroth | Mariano Rivera | 262 | 230 | 32 |
| 2005-05-26 | vs DET | 47 | W 4-3 | 26-21 | 2 | 42,835 | Kevin Brown | Jeremy Bonderman | Kevin Brown | Jeremy Bonderman | Mariano Rivera | 266 | 233 | 33 |
| 2005-05-27 | vs BOS | 48 | W 6-3 | 27-21 | 2 | 55,051 | Randy Johnson | Tim Wakefield | Randy Johnson | Tim Wakefield | Mariano Rivera | 272 | 236 | 36 |
| 2005-05-28 | vs BOS | 49 | L 1-17 | 27-22 | 2 | 55,315 | Carl Pavano | Matt Clement | Matt Clement | Carl Pavano | | 273 | 253 | 20 |
| 2005-05-29 | vs BOS | 50 | L 2-7 | 27-23 | 3 | 55,235 | Mike Mussina | David Wells | David Wells | Mike Mussina | | 275 | 260 | 15 |
| 2005-05-31 | @ KCA | 51 | L 3-5 | 27-24 | 4 | 18,680 | Kevin Brown | Zack Greinke | Zack Greinke | Kevin Brown | Mike MacDougal | 278 | 265 | 13 |
| 2005-06-01 | @ KCA | 52 | L 1-3 | 27-25 | 4 | 28,033 | Randy Johnson | D.J. Carrasco | D.J. Carrasco | Randy Johnson | Mike MacDougal | 279 | 268 | 11 |
| 2005-06-02 | @ KCA | 53 | L 2-5 | 27-26 | 4 | 25,590 | Carl Pavano | Ryan Jensen | Ryan Jensen | Carl Pavano | Ambiorix Burgos | 281 | 273 | 8 |
| 2005-06-03 | @ MIN | 54 | L 3-6 | 27-27 | 4 | 41,588 | Mike Mussina | Kyle Lohse | Kyle Lohse | Mike Mussina | Joe Nathan | 284 | 279 | 5 |
| 2005-06-04 | @ MIN | 55 | W 4-3 | 28-27 | 4 | 45,553 | Chien-Ming Wang | Joe Mays | Tom Gordon | Joe Nathan | Mariano Rivera | 288 | 282 | 6 |
| 2005-06-05 | @ MIN | 56 | L 3-9 | 28-28 | 4 | 37,349 | Kevin Brown | Carlos Silva | Carlos Silva | Kevin Brown | | 291 | 291 | 0 |
| 2005-06-06 | @ MIL | 57 | L 3-4 | 28-29 | 4 | 34,627 | Randy Johnson | Doug Davis | Doug Davis | Randy Johnson | Derrick Turnbow | 294 | 295 | -1 |
| 2005-06-07 | @ MIL | 58 | L 1-2 | 28-30 | 4 | 35,611 | Carl Pavano | Ben Sheets | Ben Sheets | Carl Pavano | Derrick Turnbow | 295 | 297 | -2 |
| 2005-06-08 | @ MIL | 59 | W 12-3 | 29-30 | 4 | 37,586 | Mike Mussina | Chris Capuano | Mike Mussina | Chris Capuano | | 307 | 300 | 7 |
| 2005-06-10 | @ SLN | 60 | L 1-8 | 29-31 | 4 | 50,250 | Chien-Ming Wang | Jason Marquis | Jason Marquis | Chien-Ming Wang | | 308 | 308 | 0 |
| 2005-06-11 | @ SLN | 61 | W 5-0 | 30-31 | 4 | 50,177 | Randy Johnson | Mark Mulder | Randy Johnson | Mark Mulder | Mariano Rivera | 313 | 308 | 5 |
| 2005-06-12 | @ SLN | 62 | L 3-5 | 30-32 | 4 | 50,372 | Carl Pavano | Matt Morris | Ray King | Tanyon Sturtze | Jason Isringhausen | 316 | 313 | 3 |
| 2005-06-14 | vs PIT | 63 | W 9-0 | 31-32 | 4 | 44,541 | Mike Mussina | Kip Wells | Mike Mussina | Kip Wells | | 325 | 313 | 12 |
| 2005-06-15 | vs PIT | 64 | W 7-5 | 32-32 | 3 | 48,828 | Kevin Brown | Mark Redman | Mariano Rivera | Jose Mesa | | 332 | 318 | 14 |
| 2005-06-16 | vs PIT | 65 | W 6-1 | 33-32 | 3 | 54,734 | Randy Johnson | Oliver Perez | Randy Johnson | Oliver Perez | | 338 | 319 | 19 |
| 2005-06-17 | vs CHN | 66 | W 9-6 | 34-32 | 3 | 54,773 | Carl Pavano | Carlos Zambrano | Mike Stanton | Will Ohman | Mariano Rivera | 347 | 325 | 22 |
| 2005-06-18 | vs CHN | 67 | W 8-1 | 35-32 | 3 | 55,284 | Chien-Ming Wang | Glendon Rusch | Chien-Ming Wang | Glendon Rusch | | 355 | 326 | 29 |
| 2005-06-19 | vs CHN | 68 | W 6-3 | 36-32 | 3 | 55,060 | Mike Mussina | Sergio Mitre | Mike Mussina | Sergio Mitre | Mariano Rivera | 361 | 329 | 32 |
| 2005-06-20 | vs TBA | 69 | L 4-5 | 36-33 | 3 | 43,543 | Sean Henn | Casey Fossum | Casey Fossum | Sean Henn | Danys Baez | 365 | 334 | 31 |
| 2005-06-21 | vs TBA | 70 | W 20-11 | 37-33 | 3 | 40,241 | Randy Johnson | Hideo Nomo | Buddy Groom | Travis Harper | | 385 | 345 | 40 |
| 2005-06-22 | vs TBA | 71 | L 3-5 | 37-34 | 3 | 48,452 | Carl Pavano | Scott Kazmir | Scott Kazmir | Carl Pavano | Danys Baez | 388 | 350 | 38 |
| 2005-06-23 | vs TBA | 72 | L 4-9 | 37-35 | 3 | 45,382 | Chien-Ming Wang | Mark Hendrickson | Mark Hendrickson | Chien-Ming Wang | Danys Baez | 392 | 359 | 33 |
| 2005-06-24 | vs NYN | 73 | L 4-6 | 37-36 | 3 | 55,297 | Mike Mussina | Pedro Martinez | Pedro Martinez | Mike Mussina | | 396 | 365 | 31 |
| 2005-06-25 | vs NYN | 74 | L 3-10 | 37-37 | 3 | 55,114 | Sean Henn | Tom Glavine | Tom Glavine | Sean Henn | | 399 | 375 | 24 |
| 2005-06-26 | vs NYN | 75 | W 5-4 | 38-37 | 3 | 55,327 | Randy Johnson | Kris Benson | Mariano Rivera | Braden Looper | | 404 | 379 | 25 |
| 2005-06-27 | @ BAL | 76 | W 6-4 | 39-37 | 3 | 45,801 | Carl Pavano | Daniel Cabrera | Tanyon Sturtze | Steve Kline | Mariano Rivera | 410 | 383 | 27 |
| 2005-06-28 | @ BAL | 77 | L 4-5 | 39-38 | 3 | 47,465 | Chien-Ming Wang | Sidney Ponson | B.J. Ryan | Mike Stanton | | 414 | 388 | 26 |
| 2005-07-01 | @ DET | 78 | L 2-10 | 39-39 | 4 | 40,776 | Randy Johnson | Jeremy Bonderman | Jeremy Bonderman | Randy Johnson | | 416 | 398 | 18 |
| 2005-07-02 | @ DET | 79 | W 8-4 | 40-39 | 3 | 41,207 | Mike Mussina | Sean Douglass | Tom Gordon | Troy Percival | | 424 | 402 | 22 |
| 2005-07-03 | @ DET | 80 | W 1-0 | 41-39 | 3 | 40,056 | Chien-Ming Wang | Nate Robertson | Chien-Ming Wang | Nate Robertson | Mariano Rivera | 425 | 402 | 23 |
| 2005-07-04 | vs BAL | 81 | W 13-8 | 42-39 | 3 | 53,844 | Tanyon Sturtze | Bruce Chen | Jason Anderson | B.J. Ryan | | 438 | 410 | 28 |
| 2005-07-05 | vs BAL | 82 | W 12-3 | 43-39 | 3 | 55,276 | Randy Johnson | Rodrigo Lopez | Randy Johnson | Rodrigo Lopez | | 450 | 413 | 37 |
| 2005-07-07 | vs CLE | 83 | W 7-2 | 44-39 | 3 | 52,201 | Mike Mussina | Kevin Millwood | Mike Mussina | Kevin Millwood | | 457 | 415 | 42 |
| 2005-07-08 | vs CLE | 84 | W 5-4 | 45-39 | 2 | 52,938 | Chien-Ming Wang | Cliff Lee | Chien-Ming Wang | Cliff Lee | Mariano Rivera | 462 | 419 | 43 |
| 2005-07-09 | vs CLE | 85 | L 7-8 | 45-40 | 3 | 54,366 | Darrell May | Scott Elarton | Scott Elarton | Darrell May | Bob Wickman | 469 | 427 | 42 |
| 2005-07-10 | vs CLE | 86 | W 9-4 | 46-40 | 3 | 54,256 | Randy Johnson | Jake Westbrook | Randy Johnson | Jake Westbrook | Mariano Rivera | 478 | 431 | 47 |
| 2005-07-14 | @ BOS | 87 | W 8-6 | 47-40 | 3 | 35,232 | Mike Mussina | Bronson Arroyo | Tom Gordon | Curt Schilling | Mariano Rivera | 486 | 437 | 49 |
| 2005-07-15 | @ BOS | 88 | L 1-17 | 47-41 | 3 | 35,083 | Tim Redding | David Wells | David Wells | Tim Redding | | 487 | 454 | 33 |
| 2005-07-16 | @ BOS | 89 | W 7-4 | 48-41 | 3 | 34,694 | Randy Johnson | Matt Clement | Randy Johnson | Matt Clement | Mariano Rivera | 494 | 458 | 36 |
| 2005-07-17 | @ BOS | 90 | W 5-3 | 49-41 | 2 | 34,802 | Al Leiter | Tim Wakefield | Al Leiter | Tim Wakefield | Mariano Rivera | 499 | 461 | 38 |
| 2005-07-18 | @ TEX | 91 | W 11-10 | 50-41 | 1 | 46,538 | Kevin Brown | Ricardo Rodriguez | Tanyon Sturtze | Doug Brocail | Mariano Rivera | 510 | 471 | 39 |
| 2005-07-19 | @ TEX | 92 | L 1-2 | 50-42 | 2 | 45,208 | Mike Mussina | Chan Ho Park | Kameron Loe | Wayne Franklin | Francisco Cordero | 511 | 473 | 38 |
| 2005-07-20 | @ TEX | 93 | W 8-4 | 51-42 | 2 | 45,354 | Aaron Small | Joaquin Benoit | Aaron Small | Joaquin Benoit | | 519 | 477 | 42 |
| 2005-07-21 | @ ANA | 94 | L 5-6 | 51-43 | 2 | 44,109 | Randy Johnson | Bartolo Colon | Bartolo Colon | Tom Gordon | Francisco Rodriguez | 524 | 483 | 41 |
| 2005-07-22 | @ ANA | 95 | L 3-6 | 51-44 | 2 | 44,043 | Al Leiter | John Lackey | John Lackey | Al Leiter | Francisco Rodriguez | 527 | 489 | 38 |
| 2005-07-23 | @ ANA | 96 | L 6-8 | 51-45 | 2 | 44,035 | Kevin Brown | Ervin Santana | Ervin Santana | Kevin Brown | Francisco Rodriguez | 533 | 497 | 36 |
| 2005-07-24 | @ ANA | 97 | W 4-1 | 52-45 | 2 | 44,032 | Mike Mussina | Jarrod Washburn | Mike Mussina | Jarrod Washburn | Mariano Rivera | 537 | 498 | 39 |
| 2005-07-26 | vs MIN | 98 | W 4-0 | 53-45 | 2 | 53,855 | Randy Johnson | Brad Radke | Randy Johnson | Brad Radke | | 541 | 498 | 43 |
| 2005-07-27 | vs MIN | 99 | L 3-7 | 53-46 | 2 | 50,334 | Al Leiter | Johan Santana | Johan Santana | Al Leiter | Joe Nathan | 544 | 505 | 39 |
| 2005-07-28 | vs MIN | 100 | W 6-3 | 54-46 | 2 | 53,524 | Aaron Small | Joe Mays | Aaron Small | Joe Mays | Mariano Rivera | 550 | 508 | 42 |
| 2005-07-29 | vs ANA | 101 | L 1-4 | 54-47 | 2 | 54,025 | Mike Mussina | Ervin Santana | Ervin Santana | Mike Mussina | Francisco Rodriguez | 551 | 512 | 39 |
| 2005-07-30 | vs ANA | 102 | W 8-7 | 55-47 | 2 | 54,220 | Shawn Chacon | Paul Byrd | Mariano Rivera | Francisco Rodriguez | | 559 | 519 | 40 |
| 2005-07-31 | vs ANA | 103 | W 8-7 | 56-47 | 2 | 53,653 | Randy Johnson | Chris Bootcheck | Tom Gordon | Kevin Gregg | | 567 | 526 | 41 |
| 2005-08-02 | @ CLE | 104 | L 5-6 | 56-48 | 2 | 34,457 | Al Leiter | Scott Elarton | Scott Elarton | Al Leiter | Bob Wickman | 572 | 532 | 40 |
| 2005-08-03 | @ CLE | 105 | L 4-7 | 56-49 | 2 | 35,737 | Mike Mussina | Cliff Lee | Cliff Lee | Mike Mussina | Bob Wickman | 576 | 539 | 37 |
| 2005-08-04 | @ CLE | 106 | W 4-3 | 57-49 | 2 | 40,048 | Shawn Chacon | Kevin Millwood | Tom Gordon | Bob Wickman | Mariano Rivera | 580 | 542 | 38 |
| 2005-08-05 | @ TOR | 107 | W 6-2 | 58-49 | 2 | 43,688 | Aaron Small | Gustavo Chacin | Aaron Small | Gustavo Chacin | Mariano Rivera | 586 | 544 | 42 |
| 2005-08-06 | @ TOR | 108 | L 5-8 | 58-50 | 2 | 48,088 | Randy Johnson | Scott Downs | Pete Walker | Randy Johnson | | 591 | 552 | 39 |
| 2005-08-07 | @ TOR | 109 | W 6-2 | 59-50 | 2 | 46,114 | Al Leiter | Josh Towers | Al Leiter | Josh Towers | Mariano Rivera | 597 | 554 | 43 |
| 2005-08-08 | vs CHA | 110 | W 3-2 | 60-50 | 2 | 54,871 | Mike Mussina | Orlando Hernandez | Mike Mussina | Orlando Hernandez | Mariano Rivera | 600 | 556 | 44 |
| 2005-08-09 | vs CHA | 111 | L 1-2 | 60-51 | 2 | 53,946 | Shawn Chacon | Jose Contreras | Jose Contreras | Shawn Chacon | Dustin Hermanson | 601 | 558 | 43 |
| 2005-08-10 | vs CHA | 112 | L 1-2 | 60-52 | 2 | 54,635 | Aaron Small | Freddy Garcia | Neal Cotts | Mariano Rivera | Dustin Hermanson | 602 | 560 | 42 |
| 2005-08-11 | vs TEX | 113 | W 9-8 | 61-52 | 2 | 54,283 | Scott Proctor | John Wasdin | Tanyon Sturtze | James Baldwin | Mariano Rivera | 611 | 568 | 43 |
| 2005-08-12 | vs TEX | 114 | W 6-5 | 62-52 | 2 | 54,442 | Al Leiter | Chris Young | Al Leiter | C.J. Wilson | Tanyon Sturtze | 617 | 573 | 44 |
| 2005-08-13 | vs TEX | 115 | W 7-5 | 63-52 | 2 | 54,919 | Mike Mussina | Juan Dominguez | Aaron Small | Kameron Loe | | 624 | 578 | 46 |
| 2005-08-14 | vs TEX | 116 | W 10-3 | 64-52 | 2 | 54,824 | Shawn Chacon | Joaquin Benoit | Shawn Chacon | Joaquin Benoit | | 634 | 581 | 53 |
| 2005-08-15 | @ TBA | 117 | W 5-2 | 65-52 | 2 | 19,320 | Jaret Wright | Casey Fossum | Jaret Wright | Casey Fossum | Mariano Rivera | 639 | 583 | 56 |
| 2005-08-16 | @ TBA | 118 | L 3-4 | 65-53 | 2 | 20,678 | Randy Johnson | Doug Waechter | Chad Orvella | Alan Embree | | 642 | 587 | 55 |
| 2005-08-17 | @ TBA | 119 | L 6-7 | 65-54 | 2 | 20,178 | Al Leiter | Mark Hendrickson | Trever Miller | Tanyon Sturtze | Danys Baez | 648 | 594 | 54 |
| 2005-08-19 | @ CHA | 120 | W 3-1 | 66-54 | 2 | 39,496 | Mike Mussina | Jon Garland | Mike Mussina | Jon Garland | Mariano Rivera | 651 | 595 | 56 |
| 2005-08-20 | @ CHA | 121 | W 5-0 | 67-54 | 2 | 38,938 | Shawn Chacon | Orlando Hernandez | Shawn Chacon | Orlando Hernandez | | 656 | 595 | 61 |
| 2005-08-21 | @ CHA | 122 | L 2-6 | 67-55 | 2 | 39,480 | Randy Johnson | Jose Contreras | Jose Contreras | Randy Johnson | | 658 | 601 | 57 |
| 2005-08-22 | vs TOR | 123 | W 7-0 | 68-55 | 2 | 50,162 | Jaret Wright | Scott Downs | Jaret Wright | Scott Downs | | 665 | 601 | 64 |
| 2005-08-23 | vs TOR | 124 | W 5-4 | 69-55 | 2 | 50,528 | Al Leiter | Josh Towers | Mariano Rivera | Miguel Batista | | 670 | 605 | 65 |
| 2005-08-24 | vs TOR | 125 | L 5-9 | 69-56 | 2 | 54,705 | Mike Mussina | David Bush | David Bush | Mike Mussina | | 675 | 614 | 61 |
| 2005-08-25 | vs TOR | 126 | W 6-2 | 70-56 | 2 | 54,329 | Shawn Chacon | Gustavo Chacin | Shawn Chacon | Gustavo Chacin | | 681 | 616 | 65 |
| 2005-08-26 | vs KCA | 127 | W 5-1 | 71-56 | 2 | 53,922 | Randy Johnson | Mike Wood | Randy Johnson | Mike Wood | | 686 | 617 | 69 |
| 2005-08-27 | vs KCA | 128 | W 8-7 | 72-56 | 2 | 54,452 | Jaret Wright | J.P. Howell | Alan Embree | Shawn Camp | | 694 | 624 | 70 |
| 2005-08-28 | vs KCA | 129 | W 10-3 | 73-56 | 2 | 54,951 | Al Leiter | Zack Greinke | Al Leiter | Zack Greinke | | 704 | 627 | 77 |
| 2005-08-29 | @ SEA | 130 | W 7-4 | 74-56 | 2 | 41,731 | Mike Mussina | Ryan Franklin | Aaron Small | Matt Thornton | Mariano Rivera | 711 | 631 | 80 |
| 2005-08-30 | @ SEA | 131 | L 3-8 | 74-57 | 2 | 37,773 | Shawn Chacon | Jeff Harris | Jeff Harris | Shawn Chacon | | 714 | 639 | 75 |
| 2005-08-31 | @ SEA | 132 | W 2-0 | 75-57 | 2 | 46,240 | Randy Johnson | Felix Hernandez | Randy Johnson | Felix Hernandez | Mariano Rivera | 716 | 639 | 77 |
| 2005-09-01 | @ SEA | 133 | L 1-5 | 75-58 | 2 | 39,986 | Jaret Wright | Joel Pineiro | George Sherrill | Tanyon Sturtze | | 717 | 644 | 73 |
| 2005-09-02 | @ OAK | 134 | L 0-12 | 75-59 | 2 | 36,048 | Al Leiter | Dan Haren | Dan Haren | Al Leiter | | 717 | 656 | 61 |
| 2005-09-03 | @ OAK | 135 | W 7-0 | 76-59 | 2 | 40,076 | Aaron Small | Kirk Saarloos | Aaron Small | Kirk Saarloos | | 724 | 656 | 68 |
| 2005-09-04 | @ OAK | 136 | W 7-3 | 77-59 | 2 | 43,874 | Shawn Chacon | Barry Zito | Shawn Chacon | Barry Zito | | 731 | 659 | 72 |
| 2005-09-06 | vs TBA | 137 | L 3-4 | 77-60 | 2 | 48,820 | Randy Johnson | Casey Fossum | Chad Orvella | Mariano Rivera | Danys Baez | 734 | 663 | 71 |
| 2005-09-07 | vs TBA | 138 | W 5-4 | 78-60 | 2 | 52,928 | Jaret Wright | Doug Waechter | Tanyon Sturtze | Joe Borowski | Mariano Rivera | 739 | 667 | 72 |
| 2005-09-08 | vs TBA | 139 | L 4-7 | 78-61 | 2 | 49,673 | Chien-Ming Wang | Mark Hendrickson | Mark Hendrickson | Chien-Ming Wang | Danys Baez | 743 | 674 | 69 |
| 2005-09-09 | vs BOS | 140 | W 8-4 | 79-61 | 2 | 55,024 | Aaron Small | David Wells | Aaron Small | David Wells | | 751 | 678 | 73 |
| 2005-09-10 | vs BOS | 141 | L 2-9 | 79-62 | 2 | 55,076 | Shawn Chacon | Curt Schilling | Curt Schilling | Shawn Chacon | | 753 | 687 | 66 |
| 2005-09-11 | vs BOS | 142 | W 1-0 | 80-62 | 2 | 55,123 | Randy Johnson | Tim Wakefield | Randy Johnson | Tim Wakefield | Mariano Rivera | 754 | 687 | 67 |
| 2005-09-13 | @ TBA | 143 | W 17-3 | 81-62 | 2 | 14,048 | Jaret Wright | Doug Waechter | Jaret Wright | Doug Waechter | | 771 | 690 | 81 |
| 2005-09-14 | @ TBA | 144 | W 6-5 | 82-62 | 2 | 14,396 | Chien-Ming Wang | Mark Hendrickson | Chien-Ming Wang | Chad Orvella | Mariano Rivera | 777 | 695 | 82 |
| 2005-09-15 | @ TBA | 145 | W 9-5 | 83-62 | 2 | 18,391 | Aaron Small | Seth McClung | Aaron Small | Seth McClung | Mariano Rivera | 786 | 700 | 86 |
| 2005-09-16 | @ TOR | 146 | W 11-10 | 84-62 | 2 | 36,543 | Randy Johnson | David Bush | Scott Proctor | David Bush | Mariano Rivera | 797 | 710 | 87 |
| 2005-09-17 | @ TOR | 147 | W 1-0 | 85-62 | 2 | 43,433 | Shawn Chacon | Gustavo Chacin | Shawn Chacon | Gustavo Chacin | Tom Gordon | 798 | 710 | 88 |
| 2005-09-18 | @ TOR | 148 | L 5-6 | 85-63 | 2 | 39,891 | Jaret Wright | Ted Lilly | Ted Lilly | Jaret Wright | Miguel Batista | 803 | 716 | 87 |
| 2005-09-19 | vs BAL | 149 | W 3-2 | 86-63 | 2 | 51,521 | Chien-Ming Wang | Erik Bedard | Mariano Rivera | Eric DuBose | | 806 | 718 | 88 |
| 2005-09-20 | vs BAL | 150 | W 12-9 | 87-63 | 2 | 46,982 | Aaron Small | John Maine | Aaron Small | John Maine | | 818 | 727 | 91 |
| 2005-09-21 | vs BAL | 151 | W 2-1 | 88-63 | 1 | 50,382 | Randy Johnson | Rodrigo Lopez | Randy Johnson | Rodrigo Lopez | Mariano Rivera | 820 | 728 | 92 |
| 2005-09-22 | vs BAL | 152 | W 7-6 | 89-63 | 1 | 52,368 | Mike Mussina | Bruce Chen | Mike Mussina | Bruce Chen | Tom Gordon | 827 | 734 | 93 |
| 2005-09-23 | vs TOR | 153 | W 5-0 | 90-63 | 1 | 53,175 | Shawn Chacon | Ted Lilly | Shawn Chacon | Ted Lilly | | 832 | 734 | 98 |
| 2005-09-24 | vs TOR | 154 | L 4-7 | 90-64 | 2 | 53,911 | Jaret Wright | Scott Downs | Scott Downs | Jaret Wright | Miguel Batista | 836 | 741 | 95 |
| 2005-09-25 | vs TOR | 155 | W 8-4 | 91-64 | 2 | 55,136 | Chien-Ming Wang | Josh Towers | Chien-Ming Wang | Josh Towers | Mariano Rivera | 844 | 745 | 99 |
| 2005-09-26 | @ BAL | 156 | W 11-3 | 92-64 | 1 | 43,039 | Randy Johnson | Rodrigo Lopez | Randy Johnson | Rodrigo Lopez | | 855 | 748 | 107 |
| 2005-09-27 | @ BAL | 157 | L 9-17 | 92-65 | 2 | 29,557 | Mike Mussina | Bruce Chen | Aaron Rakers | Al Leiter | | 864 | 765 | 99 |
| 2005-09-28 | @ BAL | 158 | W 2-1 | 93-65 | 1 | 30,539 | Shawn Chacon | Daniel Cabrera | Shawn Chacon | Daniel Cabrera | Mariano Rivera | 866 | 766 | 100 |
| 2005-09-29 | @ BAL | 159 | W 8-4 | 94-65 | 1 | 36,821 | Aaron Small | Erik Bedard | Aaron Small | Erik Bedard | | 874 | 770 | 104 |
| 2005-09-30 | @ BOS | 160 | L 3-5 | 94-66 | 2 | 34,832 | Chien-Ming Wang | David Wells | David Wells | Chien-Ming Wang | Mike Timlin | 877 | 775 | 102 |
| 2005-10-01 | @ BOS | 161 | W 8-4 | 95-66 | 1 | 34,556 | Randy Johnson | Tim Wakefield | Randy Johnson | Tim Wakefield | | 885 | 779 | 106 |
| 2005-10-02 | @ BOS | 162 | L 1-10 | 95-67 | 2 | 34,534 | Jaret Wright | Curt Schilling | Curt Schilling | Jaret Wright | | 886 | 789 | 97 |