| 2005-04-04 | vs CHN | 1 | L 6-16 | 0-1 | 2 | 45,539 | Javier Vazquez | Carlos Zambrano | Glendon Rusch | Javier Vazquez | | 6 | 16 | -10 |
| 2005-04-05 | vs CHN | 2 | W 5-4 | 1-1 | 3 | 30,260 | Russ Ortiz | Greg Maddux | Russ Ortiz | Greg Maddux | Brandon Lyon | 11 | 20 | -9 |
| 2005-04-06 | vs CHN | 3 | W 8-3 | 2-1 | 1 | 26,789 | Brandon Webb | Ryan Dempster | Brandon Webb | Ryan Dempster | | 19 | 23 | -4 |
| 2005-04-08 | vs LAN | 4 | L 7-8 | 2-2 | 2 | 25,813 | Shawn Estes | Elmer Dessens | Steve Schmoll | Brandon Lyon | Yhency Brazoban | 26 | 31 | -5 |
| 2005-04-09 | vs LAN | 5 | L 10-12 | 2-3 | 4 | 30,753 | Javier Vazquez | Scott Erickson | Yhency Brazoban | Mike Gosling | Steve Schmoll | 36 | 43 | -7 |
| 2005-04-10 | vs LAN | 6 | W 5-4 | 3-3 | 3 | 29,796 | Russ Ortiz | Derek Lowe | Mike Koplove | Duaner Sanchez | Brandon Lyon | 41 | 47 | -6 |
| 2005-04-11 | vs COL | 7 | W 2-0 | 4-3 | 3 | 18,742 | Brad Halsey | Jason Jennings | Brad Halsey | Jason Jennings | Brandon Lyon | 43 | 47 | -4 |
| 2005-04-12 | vs COL | 8 | W 4-2 | 5-3 | 2 | 20,725 | Brandon Webb | Shawn Chacon | Brandon Webb | Brian Fuentes | Brandon Lyon | 47 | 49 | -2 |
| 2005-04-13 | vs COL | 9 | W 5-2 | 6-3 | 2 | 19,272 | Shawn Estes | Jeff Francis | Shawn Estes | Byung-Hyun Kim | Brian Bruney | 52 | 51 | 1 |
| 2005-04-14 | @ WAS | 10 | L 3-5 | 6-4 | 2 | 45,596 | Javier Vazquez | Livan Hernandez | Livan Hernandez | Javier Vazquez | Chad Cordero | 55 | 56 | -1 |
| 2005-04-16 | @ WAS | 11 | L 3-9 | 6-5 | 2 | 34,943 | Russ Ortiz | John Patterson | John Patterson | Russ Ortiz | | 58 | 65 | -7 |
| 2005-04-17 | @ WAS | 12 | L 3-7 | 6-6 | 3 | 35,463 | Brad Halsey | Esteban Loaiza | T.J. Tucker | Mike Koplove | | 61 | 72 | -11 |
| 2005-04-18 | @ COL | 13 | W 5-3 | 7-6 | 2 | 18,563 | Brandon Webb | Shawn Chacon | Brandon Webb | Ryan Speier | Brandon Lyon | 66 | 75 | -9 |
| 2005-04-19 | @ COL | 14 | L 1-8 | 7-7 | 2 | 18,235 | Shawn Estes | Jeff Francis | Jeff Francis | Shawn Estes | | 67 | 83 | -16 |
| 2005-04-20 | @ SFN | 15 | W 2-1 | 8-7 | 2 | 36,955 | Javier Vazquez | Noah Lowry | Javier Vazquez | Noah Lowry | Brandon Lyon | 69 | 84 | -15 |
| 2005-04-21 | @ SFN | 16 | L 3-4 | 8-8 | 2 | 34,824 | Russ Ortiz | Jason Schmidt | Tyler Walker | Mike Gosling | | 72 | 88 | -16 |
| 2005-04-22 | vs SDN | 17 | W 5-3 | 9-8 | 2 | 26,407 | Brad Halsey | Tim Redding | Brad Halsey | Tim Redding | Brandon Lyon | 77 | 91 | -14 |
| 2005-04-23 | vs SDN | 18 | W 2-1 | 10-8 | 2 | 30,760 | Brandon Webb | Jake Peavy | Mike Koplove | Akinori Otsuka | | 79 | 92 | -13 |
| 2005-04-24 | vs SDN | 19 | W 8-6 | 11-8 | 2 | 30,471 | Shawn Estes | Brian Lawrence | Shawn Estes | Brian Lawrence | Brandon Lyon | 87 | 98 | -11 |
| 2005-04-25 | @ LAN | 20 | W 4-2 | 12-8 | 2 | 36,876 | Javier Vazquez | Derek Lowe | Javier Vazquez | Derek Lowe | Brandon Lyon | 91 | 100 | -9 |
| 2005-04-26 | @ LAN | 21 | W 3-2 | 13-8 | 2 | 44,486 | Russ Ortiz | Scott Erickson | Russ Ortiz | Scott Erickson | Brandon Lyon | 94 | 102 | -8 |
| 2005-04-27 | @ LAN | 22 | W 6-3 | 14-8 | 1 | 54,387 | Brad Halsey | Jeff Weaver | Lance Cormier | Jeff Weaver | Javier Lopez | 100 | 105 | -5 |
| 2005-04-29 | @ SDN | 23 | L 4-5 | 14-9 | 2 | 41,464 | Brandon Webb | Jake Peavy | Chris Hammond | Brandon Lyon | | 104 | 110 | -6 |
| 2005-04-30 | @ SDN | 24 | L 0-2 | 14-10 | 2 | 38,148 | Shawn Estes | Brian Lawrence | Brian Lawrence | Shawn Estes | Trevor Hoffman | 104 | 112 | -8 |
| 2005-05-01 | @ SDN | 25 | W 5-2 | 15-10 | 2 | 35,165 | Javier Vazquez | Woody Williams | Javier Vazquez | Woody Williams | | 109 | 114 | -5 |
| 2005-05-02 | vs SFN | 26 | L 8-9 | 15-11 | 2 | 25,317 | Russ Ortiz | Jason Schmidt | Jim Brower | Brian Bruney | Tyler Walker | 117 | 123 | -6 |
| 2005-05-03 | vs SFN | 27 | W 3-2 | 16-11 | 2 | 28,072 | Brad Halsey | Kirk Rueter | Javier Lopez | Matt Herges | Brandon Lyon | 120 | 125 | -5 |
| 2005-05-04 | vs SFN | 28 | W 6-2 | 17-11 | 2 | 21,367 | Brandon Webb | Brett Tomko | Brandon Webb | Brett Tomko | | 126 | 127 | -1 |
| 2005-05-05 | vs PIT | 29 | L 2-6 | 17-12 | 2 | 18,906 | Shawn Estes | David Williams | David Williams | Shawn Estes | | 128 | 133 | -5 |
| 2005-05-06 | vs PIT | 30 | W 8-4 | 18-12 | 2 | 24,056 | Javier Vazquez | Oliver Perez | Javier Vazquez | Oliver Perez | | 136 | 137 | -1 |
| 2005-05-07 | vs PIT | 31 | L 2-3 | 18-13 | 2 | 32,879 | Russ Ortiz | Josh Fogg | Josh Fogg | Russ Ortiz | Jose Mesa | 138 | 140 | -2 |
| 2005-05-08 | vs PIT | 32 | L 2-16 | 18-14 | 2 | 24,526 | Brad Halsey | Kip Wells | Kip Wells | Brad Halsey | | 140 | 156 | -16 |
| 2005-05-09 | vs WAS | 33 | L 3-4 | 18-15 | 2 | 19,440 | Brandon Webb | Livan Hernandez | Livan Hernandez | Jose Valverde | Chad Cordero | 143 | 160 | -17 |
| 2005-05-10 | vs WAS | 34 | W 3-2 | 19-15 | 2 | 23,181 | Shawn Estes | Tony Armas | Shawn Estes | Tony Armas | Brandon Lyon | 146 | 162 | -16 |
| 2005-05-11 | vs WAS | 35 | W 3-2 | 20-15 | 2 | 21,011 | Javier Vazquez | Claudio Vargas | Lance Cormier | Jon Rauch | Brandon Lyon | 149 | 164 | -15 |
| 2005-05-12 | @ COL | 36 | W 6-3 | 21-15 | 2 | 18,184 | Russ Ortiz | Shawn Chacon | Russ Ortiz | Shawn Chacon | | 155 | 167 | -12 |
| 2005-05-13 | @ COL | 37 | L 3-18 | 21-16 | 2 | 20,233 | Brad Halsey | Jeff Francis | Jeff Francis | Brad Halsey | | 158 | 185 | -27 |
| 2005-05-14 | @ COL | 38 | W 10-4 | 22-16 | 2 | 23,367 | Brandon Webb | Jamey Wright | Brandon Webb | Jamey Wright | | 168 | 189 | -21 |
| 2005-05-15 | @ COL | 39 | W 5-4 | 23-16 | 1 | 28,071 | Shawn Estes | Jason Jennings | Shawn Estes | Jason Jennings | Brian Bruney | 173 | 193 | -20 |
| 2005-05-17 | @ HOU | 40 | L 0-3 | 23-17 | 2 | 27,156 | Javier Vazquez | Roy Oswalt | Roy Oswalt | Javier Vazquez | Brad Lidge | 173 | 196 | -23 |
| 2005-05-18 | @ HOU | 41 | W 7-6 | 24-17 | 2 | 27,790 | Russ Ortiz | Andy Pettitte | Russ Ortiz | Andy Pettitte | Brian Bruney | 180 | 202 | -22 |
| 2005-05-19 | @ HOU | 42 | W 6-1 | 25-17 | 2 | 32,132 | Brad Halsey | Roger Clemens | Brad Halsey | Roger Clemens | Jose Valverde | 186 | 203 | -17 |
| 2005-05-20 | @ DET | 43 | W 6-2 | 26-17 | 2 | 30,119 | Brandon Webb | Jeremy Bonderman | Brandon Webb | Jamie Walker | Brian Bruney | 192 | 205 | -13 |
| 2005-05-21 | @ DET | 44 | L 2-3 | 26-18 | 2 | 30,134 | Shawn Estes | Nate Robertson | Franklyn German | Brian Bruney | | 194 | 208 | -14 |
| 2005-05-22 | @ DET | 45 | W 1-0 | 27-18 | 1 | 23,124 | Javier Vazquez | Jason Johnson | Javier Vazquez | Jason Johnson | | 195 | 208 | -13 |
| 2005-05-24 | vs SDN | 46 | L 5-9 | 27-19 | 2 | 24,759 | Russ Ortiz | Adam Eaton | Adam Eaton | Russ Ortiz | Trevor Hoffman | 200 | 217 | -17 |
| 2005-05-25 | vs SDN | 47 | W 12-11 | 28-19 | 1 | 20,769 | Brad Halsey | Darrell May | Jose Valverde | Akinori Otsuka | Brian Bruney | 212 | 228 | -16 |
| 2005-05-26 | vs SDN | 48 | L 0-10 | 28-20 | 2 | 21,127 | Brandon Webb | Jake Peavy | Jake Peavy | Brandon Webb | | 212 | 238 | -26 |
| 2005-05-27 | vs LAN | 49 | L 4-7 | 28-21 | 2 | 26,601 | Shawn Estes | Derek Lowe | Kelly Wunsch | Jose Valverde | Eric Gagne | 216 | 245 | -29 |
| 2005-05-28 | vs LAN | 50 | W 5-4 | 29-21 | 2 | 33,725 | Javier Vazquez | Derek Thompson | Lance Cormier | Giovanni Carrara | | 221 | 249 | -28 |
| 2005-05-29 | vs LAN | 51 | L 3-6 | 29-22 | 2 | 33,621 | Russ Ortiz | Jeff Weaver | Jeff Weaver | Russ Ortiz | Eric Gagne | 224 | 255 | -31 |
| 2005-05-31 | @ NYN | 52 | W 7-0 | 30-22 | 2 | 33,955 | Brad Halsey | Kris Benson | Brad Halsey | Kris Benson | | 231 | 255 | -24 |
| 2005-06-01 | @ NYN | 53 | L 1-2 | 30-23 | 2 | 33,436 | Brandon Webb | Victor Zambrano | Victor Zambrano | Brandon Webb | Braden Looper | 232 | 257 | -25 |
| 2005-06-02 | @ NYN | 54 | L 1-6 | 30-24 | 2 | 28,260 | Shawn Estes | Pedro Martinez | Pedro Martinez | Shawn Estes | | 233 | 263 | -30 |
| 2005-06-04 | @ PHI | 55 | L 6-10 | 30-26 | 2 | 0 | Javier Vazquez | Vicente Padilla | Vicente Padilla | Javier Vazquez | | 239 | 273 | -34 |
| 2005-06-04 | @ PHI | 56 | L 3-5 | 30-26 | 2 | 43,449 | Russ Ortiz | Brett Myers | Brett Myers | Russ Ortiz | Billy Wagner | 242 | 278 | -36 |
| 2005-06-05 | @ PHI | 57 | L 6-7 | 30-27 | 2 | 37,582 | Brad Halsey | Randy Wolf | Randy Wolf | Brad Halsey | Billy Wagner | 248 | 285 | -37 |
| 2005-06-06 | @ PHI | 58 | W 10-8 | 31-27 | 2 | 25,570 | Brandon Webb | Cory Lidle | Brandon Webb | Cory Lidle | Javier Lopez | 258 | 293 | -35 |
| 2005-06-07 | vs MIN | 59 | L 8-9 | 31-28 | 2 | 27,901 | Shawn Estes | Brad Radke | Juan Rincon | Jose Valverde | Joe Nathan | 266 | 302 | -36 |
| 2005-06-08 | vs MIN | 60 | L 0-10 | 31-29 | 3 | 23,404 | Claudio Vargas | Johan Santana | Johan Santana | Claudio Vargas | | 266 | 312 | -46 |
| 2005-06-09 | vs MIN | 61 | W 4-3 | 32-29 | 3 | 22,139 | Javier Vazquez | Kyle Lohse | Javier Vazquez | Kyle Lohse | Brian Bruney | 270 | 315 | -45 |
| 2005-06-10 | vs KCA | 62 | W 12-11 | 33-29 | 3 | 22,731 | Russ Ortiz | Zack Greinke | Brian Bruney | Mike MacDougal | | 282 | 326 | -44 |
| 2005-06-11 | vs KCA | 63 | L 5-8 | 33-30 | 3 | 27,996 | Brad Halsey | J.P. Howell | J.P. Howell | Brad Halsey | | 287 | 334 | -47 |
| 2005-06-12 | vs KCA | 64 | L 4-9 | 33-31 | 3 | 25,965 | Brandon Webb | D.J. Carrasco | Ryan Jensen | Javier Lopez | | 291 | 343 | -52 |
| 2005-06-13 | @ CHA | 65 | W 8-1 | 34-31 | 3 | 32,952 | Shawn Estes | Jose Contreras | Shawn Estes | Jose Contreras | | 299 | 344 | -45 |
| 2005-06-14 | @ CHA | 66 | W 10-4 | 35-31 | 2 | 24,831 | Javier Vazquez | Orlando Hernandez | Javier Vazquez | Orlando Hernandez | | 309 | 348 | -39 |
| 2005-06-15 | @ CHA | 67 | L 6-12 | 35-32 | 2 | 24,499 | Russ Ortiz | Jon Garland | Jon Garland | Russ Ortiz | | 315 | 360 | -45 |
| 2005-06-17 | @ CLE | 68 | L 6-13 | 35-33 | 2 | 23,138 | Brad Halsey | Cliff Lee | Cliff Lee | Brad Halsey | | 321 | 373 | -52 |
| 2005-06-18 | @ CLE | 69 | L 1-3 | 35-34 | 2 | 28,306 | Brandon Webb | Scott Elarton | Scott Elarton | Brandon Webb | Bob Wickman | 322 | 376 | -54 |
| 2005-06-19 | @ CLE | 70 | L 2-3 | 35-35 | 2 | 27,416 | Shawn Estes | Jake Westbrook | Jake Westbrook | Shawn Estes | Bob Wickman | 324 | 379 | -55 |
| 2005-06-20 | @ SFN | 71 | L 3-8 | 35-36 | 2 | 38,891 | Javier Vazquez | Noah Lowry | Noah Lowry | Javier Vazquez | | 327 | 387 | -60 |
| 2005-06-21 | @ SFN | 72 | W 6-4 | 36-36 | 2 | 37,942 | Claudio Vargas | Brett Tomko | Claudio Vargas | Brett Tomko | Brian Bruney | 333 | 391 | -58 |
| 2005-06-22 | @ SFN | 73 | L 0-4 | 36-37 | 2 | 36,349 | Brad Halsey | Jason Schmidt | Jason Schmidt | Brad Halsey | | 333 | 395 | -62 |
| 2005-06-23 | @ SFN | 74 | W 7-2 | 37-37 | 2 | 39,739 | Brandon Webb | Kirk Rueter | Brandon Webb | Kirk Rueter | | 340 | 397 | -57 |
| 2005-06-24 | vs DET | 75 | W 2-1 | 38-37 | 2 | 24,808 | Shawn Estes | Mike Maroth | Shawn Estes | Mike Maroth | Brian Bruney | 342 | 398 | -56 |
| 2005-06-25 | vs DET | 76 | L 1-5 | 38-38 | 2 | 27,344 | Javier Vazquez | Sean Douglass | Sean Douglass | Javier Vazquez | | 343 | 403 | -60 |
| 2005-06-26 | vs DET | 77 | W 13-7 | 39-38 | 2 | 25,720 | Claudio Vargas | Jeremy Bonderman | Claudio Vargas | Jeremy Bonderman | | 356 | 410 | -54 |
| 2005-06-28 | vs SFN | 78 | L 3-11 | 39-39 | 2 | 30,640 | Brad Halsey | Jason Schmidt | Jason Schmidt | Brad Halsey | | 359 | 421 | -62 |
| 2005-06-29 | vs SFN | 79 | L 2-4 | 39-40 | 2 | 22,991 | Brandon Webb | Kirk Rueter | Jason Christiansen | Brandon Webb | Tyler Walker | 361 | 425 | -64 |
| 2005-06-30 | vs SFN | 80 | L 2-9 | 39-41 | 2 | 21,751 | Shawn Estes | Noah Lowry | Noah Lowry | Shawn Estes | Brett Tomko | 363 | 434 | -71 |
| 2005-07-01 | @ LAN | 81 | L 0-7 | 39-42 | 2 | 48,306 | Javier Vazquez | Brad Penny | Brad Penny | Javier Vazquez | | 363 | 441 | -78 |
| 2005-07-02 | @ LAN | 82 | W 7-5 | 40-42 | 2 | 44,457 | Claudio Vargas | Derek Lowe | Claudio Vargas | Derek Lowe | Brian Bruney | 370 | 446 | -76 |
| 2005-07-03 | @ LAN | 83 | W 10-3 | 41-42 | 2 | 55,868 | Brad Halsey | D.J. Houlton | Brad Halsey | D.J. Houlton | | 380 | 449 | -69 |
| 2005-07-04 | vs SLN | 84 | L 3-10 | 41-43 | 2 | 31,197 | Brandon Webb | Matt Morris | Matt Morris | Brandon Webb | | 383 | 459 | -76 |
| 2005-07-05 | vs SLN | 85 | L 1-7 | 41-44 | 2 | 23,590 | Shawn Estes | Jeff Suppan | Jeff Suppan | Shawn Estes | | 384 | 466 | -82 |
| 2005-07-06 | vs SLN | 86 | L 1-2 | 41-45 | 2 | 21,076 | Javier Vazquez | Chris Carpenter | Chris Carpenter | Javier Vazquez | Jason Isringhausen | 385 | 468 | -83 |
| 2005-07-07 | vs SLN | 87 | W 2-1 | 42-45 | 2 | 21,959 | Claudio Vargas | Jason Marquis | Lance Cormier | Ray King | | 387 | 469 | -82 |
| 2005-07-08 | vs CIN | 88 | L 3-4 | 42-46 | 2 | 23,267 | Brad Halsey | Ramon Ortiz | David Weathers | Lance Cormier | Kent Mercker | 390 | 473 | -83 |
| 2005-07-09 | vs CIN | 89 | L 2-6 | 42-47 | 2 | 27,663 | Brandon Webb | Brandon Claussen | Todd Coffey | Brandon Webb | | 392 | 479 | -87 |
| 2005-07-10 | vs CIN | 90 | W 2-0 | 43-47 | 2 | 24,414 | Mike Gosling | Eric Milton | Lance Cormier | Eric Milton | Brian Bruney | 394 | 479 | -85 |
| 2005-07-14 | @ SDN | 91 | W 6-0 | 44-47 | 2 | 38,322 | Javier Vazquez | Brian Lawrence | Javier Vazquez | Brian Lawrence | | 400 | 479 | -79 |
| 2005-07-15 | @ SDN | 92 | L 7-10 | 44-48 | 2 | 43,555 | Brandon Webb | Woody Williams | Scott Linebrink | Greg Aquino | Trevor Hoffman | 407 | 489 | -82 |
| 2005-07-16 | @ SDN | 93 | L 1-4 | 44-49 | 2 | 42,330 | Claudio Vargas | Jake Peavy | Jake Peavy | Claudio Vargas | Trevor Hoffman | 408 | 493 | -85 |
| 2005-07-17 | @ SDN | 94 | W 6-1 | 45-49 | 2 | 40,188 | Brad Halsey | Tim Stauffer | Brad Halsey | Tim Stauffer | Jose Valverde | 414 | 494 | -80 |
| 2005-07-18 | vs FLO | 95 | W 8-7 | 46-49 | 2 | 21,995 | Mike Gosling | Jason Vargas | Brandon Medders | Todd Jones | | 422 | 501 | -79 |
| 2005-07-19 | vs FLO | 96 | L 3-6 | 46-50 | 2 | 23,603 | Javier Vazquez | A.J. Burnett | A.J. Burnett | Javier Vazquez | Todd Jones | 425 | 507 | -82 |
| 2005-07-20 | vs FLO | 97 | L 2-9 | 46-51 | 2 | 20,790 | Brandon Webb | Brian Moehler | Brian Moehler | Brandon Webb | | 427 | 516 | -89 |
| 2005-07-22 | vs ATL | 98 | W 6-5 | 47-51 | 2 | 27,348 | Claudio Vargas | Tim Hudson | Lance Cormier | Jim Brower | | 433 | 521 | -88 |
| 2005-07-23 | vs ATL | 99 | L 2-3 | 47-52 | 2 | 32,673 | Brad Halsey | Jorge Sosa | Chris Reitsma | Jose Valverde | | 435 | 524 | -89 |
| 2005-07-24 | vs ATL | 100 | W 3-2 | 48-52 | 2 | 30,280 | Javier Vazquez | Horacio Ramirez | Javier Vazquez | Horacio Ramirez | Brian Bruney | 438 | 526 | -88 |
| 2005-07-25 | @ MIL | 101 | L 2-4 | 48-53 | 2 | 20,062 | Mike Gosling | Ben Sheets | Ben Sheets | Tim Worrell | Derrick Turnbow | 440 | 530 | -90 |
| 2005-07-26 | @ MIL | 102 | L 2-7 | 48-54 | 2 | 31,128 | Brandon Webb | Chris Capuano | Dana Eveland | Brandon Webb | | 442 | 537 | -95 |
| 2005-07-27 | @ MIL | 103 | W 3-0 | 49-54 | 2 | 28,971 | Claudio Vargas | Tomo Ohka | Claudio Vargas | Tomo Ohka | Brian Bruney | 445 | 537 | -92 |
| 2005-07-28 | @ CHN | 104 | W 6-0 | 50-54 | 2 | 39,154 | Brad Halsey | Jerome Williams | Brad Halsey | Jerome Williams | | 451 | 537 | -86 |
| 2005-07-29 | @ CHN | 105 | L 3-4 | 50-55 | 2 | 39,312 | Javier Vazquez | Mark Prior | Roberto Novoa | Brian Bruney | | 454 | 541 | -87 |
| 2005-07-30 | @ CHN | 106 | W 3-2 | 51-55 | 2 | 39,726 | Mike Gosling | Rich Hill | Lance Cormier | Roberto Novoa | Greg Aquino | 457 | 543 | -86 |
| 2005-07-31 | @ CHN | 107 | W 13-6 | 52-55 | 1 | 39,285 | Brandon Webb | Greg Maddux | Brandon Webb | Greg Maddux | | 470 | 549 | -79 |
| 2005-08-02 | vs HOU | 108 | L 1-3 | 52-56 | 2 | 31,696 | Claudio Vargas | Roger Clemens | Roger Clemens | Claudio Vargas | Brad Lidge | 471 | 552 | -81 |
| 2005-08-03 | vs HOU | 109 | L 0-7 | 52-57 | 2 | 22,283 | Javier Vazquez | Ezequiel Astacio | Ezequiel Astacio | Javier Vazquez | | 471 | 559 | -88 |
| 2005-08-04 | vs HOU | 110 | W 7-3 | 53-57 | 2 | 23,217 | Brad Halsey | Wandy Rodriguez | Brad Halsey | Wandy Rodriguez | Jose Valverde | 478 | 562 | -84 |
| 2005-08-05 | vs COL | 111 | L 4-6 | 53-58 | 2 | 22,596 | Brandon Webb | Aaron Cook | Mike DeJean | Lance Cormier | Brian Fuentes | 482 | 568 | -86 |
| 2005-08-06 | vs COL | 112 | L 7-14 | 53-59 | 2 | 31,186 | Mike Gosling | Jeff Francis | Jeff Francis | Mike Gosling | | 489 | 582 | -93 |
| 2005-08-07 | vs COL | 113 | W 9-4 | 54-59 | 2 | 28,028 | Claudio Vargas | Jamey Wright | Claudio Vargas | Jamey Wright | | 498 | 586 | -88 |
| 2005-08-09 | @ FLO | 114 | L 0-5 | 54-60 | 2 | 17,551 | Javier Vazquez | A.J. Burnett | A.J. Burnett | Javier Vazquez | | 498 | 591 | -93 |
| 2005-08-10 | @ FLO | 115 | L 5-10 | 54-61 | 2 | 20,443 | Brad Halsey | Jason Vargas | Jason Vargas | Brad Halsey | Todd Jones | 503 | 601 | -98 |
| 2005-08-11 | @ FLO | 116 | W 3-1 | 55-61 | 2 | 20,432 | Brandon Webb | Brian Moehler | Brandon Webb | Valerio de los Santos | Jose Valverde | 506 | 602 | -96 |
| 2005-08-12 | @ ATL | 117 | W 8-0 | 56-61 | 2 | 32,006 | Claudio Vargas | Jorge Sosa | Claudio Vargas | Jorge Sosa | | 514 | 602 | -88 |
| 2005-08-13 | @ ATL | 118 | L 5-9 | 56-62 | 2 | 36,817 | Russ Ortiz | John Thomson | John Foster | Lance Cormier | | 519 | 611 | -92 |
| 2005-08-14 | @ ATL | 119 | L 8-13 | 56-63 | 2 | 30,098 | Javier Vazquez | Mike Hampton | Mike Hampton | Javier Vazquez | | 527 | 624 | -97 |
| 2005-08-16 | @ SLN | 120 | L 2-8 | 56-64 | 2 | 42,198 | Brad Halsey | Jeff Suppan | Jeff Suppan | Brad Halsey | | 529 | 632 | -103 |
| 2005-08-17 | @ SLN | 121 | L 0-5 | 56-65 | 2 | 41,407 | Brandon Webb | Mark Mulder | Mark Mulder | Brandon Webb | | 529 | 637 | -108 |
| 2005-08-18 | @ SLN | 122 | W 9-2 | 57-65 | 2 | 44,625 | Claudio Vargas | Jason Marquis | Claudio Vargas | Jason Marquis | | 538 | 639 | -101 |
| 2005-08-19 | @ CIN | 123 | L 3-17 | 57-66 | 2 | 21,523 | Russ Ortiz | Brandon Claussen | Brandon Claussen | Russ Ortiz | | 541 | 656 | -115 |
| 2005-08-20 | @ CIN | 124 | W 6-2 | 58-66 | 2 | 26,109 | Javier Vazquez | Aaron Harang | Javier Vazquez | Jason Standridge | | 547 | 658 | -111 |
| 2005-08-21 | @ CIN | 125 | L 6-13 | 58-67 | 2 | 26,323 | Brad Halsey | Eric Milton | Eric Milton | Brad Halsey | | 553 | 671 | -118 |
| 2005-08-22 | vs NYN | 126 | L 1-4 | 58-68 | 2 | 23,371 | Brandon Webb | Tom Glavine | Tom Glavine | Brandon Webb | Braden Looper | 554 | 675 | -121 |
| 2005-08-23 | vs NYN | 127 | L 1-14 | 58-69 | 2 | 24,699 | Claudio Vargas | Victor Zambrano | Victor Zambrano | Claudio Vargas | | 555 | 689 | -134 |
| 2005-08-24 | vs NYN | 128 | L 4-18 | 58-70 | 2 | 22,268 | Russ Ortiz | Jae Weong Seo | Jae Weong Seo | Russ Ortiz | | 559 | 707 | -148 |
| 2005-08-25 | vs NYN | 129 | L 1-3 | 58-71 | 2 | 21,683 | Javier Vazquez | Pedro Martinez | Pedro Martinez | Javier Vazquez | Braden Looper | 560 | 710 | -150 |
| 2005-08-26 | vs PHI | 130 | L 3-11 | 58-72 | 2 | 22,397 | Brad Halsey | Brett Myers | Aaron Fultz | Brad Halsey | | 563 | 721 | -158 |
| 2005-08-27 | vs PHI | 131 | W 2-0 | 59-72 | 2 | 26,903 | Brandon Webb | Jon Lieber | Brandon Webb | Jon Lieber | Jose Valverde | 565 | 721 | -156 |
| 2005-08-28 | vs PHI | 132 | W 10-5 | 60-72 | 2 | 31,112 | Claudio Vargas | Vicente Padilla | Claudio Vargas | Vicente Padilla | | 575 | 726 | -151 |
| 2005-08-29 | @ SDN | 133 | W 7-5 | 61-72 | 2 | 23,762 | Russ Ortiz | Woody Williams | Russ Ortiz | Woody Williams | | 582 | 731 | -149 |
| 2005-08-30 | @ SDN | 134 | L 3-5 | 61-73 | 2 | 27,853 | Brad Halsey | Jake Peavy | Jake Peavy | Brad Halsey | Trevor Hoffman | 585 | 736 | -151 |
| 2005-08-31 | @ SDN | 135 | L 5-9 | 61-74 | 3 | 27,513 | Javier Vazquez | Chan Ho Park | Chan Ho Park | Javier Vazquez | | 590 | 745 | -155 |
| 2005-09-02 | vs SFN | 136 | L 3-6 | 61-75 | 4 | 19,961 | Brandon Webb | Jason Schmidt | Jason Schmidt | Brandon Webb | Armando Benitez | 593 | 751 | -158 |
| 2005-09-03 | vs SFN | 137 | L 4-9 | 61-76 | 4 | 29,670 | Claudio Vargas | Noah Lowry | Noah Lowry | Claudio Vargas | | 597 | 760 | -163 |
| 2005-09-04 | vs SFN | 138 | L 2-3 | 61-77 | 4 | 26,728 | Russ Ortiz | Matt Cain | Matt Cain | Russ Ortiz | Armando Benitez | 599 | 763 | -164 |
| 2005-09-06 | @ PIT | 139 | W 4-2 | 62-77 | 4 | 11,186 | Javier Vazquez | Paul Maholm | Jose Valverde | John Grabow | Buddy Groom | 603 | 765 | -162 |
| 2005-09-07 | @ PIT | 140 | W 4-2 | 63-77 | 4 | 12,066 | Brandon Webb | Mark Redman | Brandon Webb | Mark Redman | Jose Valverde | 607 | 767 | -160 |
| 2005-09-08 | @ PIT | 141 | L 7-8 | 63-78 | 4 | 10,984 | Dustin Nippert | Josh Fogg | Rick White | Buddy Groom | | 614 | 775 | -161 |
| 2005-09-09 | @ COL | 142 | W 7-1 | 64-78 | 3 | 20,045 | Shawn Estes | Byung-Hyun Kim | Shawn Estes | Byung-Hyun Kim | | 621 | 776 | -155 |
| 2005-09-10 | @ COL | 143 | W 8-5 | 65-78 | 2 | 20,284 | Claudio Vargas | Zach Day | Claudio Vargas | Zach Day | Jose Valverde | 629 | 781 | -152 |
| 2005-09-11 | @ COL | 144 | L 2-7 | 65-79 | 3 | 20,476 | Russ Ortiz | Aaron Cook | Aaron Cook | Russ Ortiz | | 631 | 788 | -157 |
| 2005-09-13 | vs MIL | 145 | L 1-3 | 65-80 | 4 | 23,708 | Javier Vazquez | Chris Capuano | Chris Capuano | Javier Vazquez | Derrick Turnbow | 632 | 791 | -159 |
| 2005-09-14 | vs MIL | 146 | W 2-1 | 66-80 | 4 | 23,793 | Brandon Webb | Doug Davis | Brandon Medders | Justin Lehr | | 634 | 792 | -158 |
| 2005-09-15 | vs MIL | 147 | L 2-14 | 66-81 | 4 | 20,741 | Shawn Estes | Tomo Ohka | Tomo Ohka | Shawn Estes | | 636 | 806 | -170 |
| 2005-09-16 | vs COL | 148 | L 5-6 | 66-82 | 4 | 20,207 | Dustin Nippert | Zach Day | Randy Williams | Brandon Medders | Brian Fuentes | 641 | 812 | -171 |
| 2005-09-17 | vs COL | 149 | W 6-5 | 67-82 | 4 | 24,701 | Claudio Vargas | Aaron Cook | Oscar Villarreal | Randy Williams | Jose Valverde | 647 | 817 | -170 |
| 2005-09-18 | vs COL | 150 | L 1-7 | 67-83 | 4 | 24,351 | Russ Ortiz | Jeff Francis | Jeff Francis | Russ Ortiz | | 648 | 824 | -176 |
| 2005-09-20 | vs LAN | 151 | W 4-1 | 68-83 | 3 | 23,907 | Javier Vazquez | Derek Lowe | Javier Vazquez | Derek Lowe | Jose Valverde | 652 | 825 | -173 |
| 2005-09-21 | vs LAN | 152 | W 3-2 | 69-83 | 3 | 19,469 | Brandon Webb | Brad Penny | Brandon Webb | Franquelis Osoria | Jose Valverde | 655 | 827 | -172 |
| 2005-09-22 | vs LAN | 153 | W 7-4 | 70-83 | 3 | 18,808 | Shawn Estes | Jeff Weaver | Jason Bulger | Duaner Sanchez | | 662 | 831 | -169 |
| 2005-09-23 | vs SDN | 154 | L 3-5 | 70-84 | 3 | 30,303 | Claudio Vargas | Pedro Astacio | Pedro Astacio | Claudio Vargas | Trevor Hoffman | 665 | 836 | -171 |
| 2005-09-24 | vs SDN | 155 | W 8-5 | 71-84 | 3 | 26,778 | Russ Ortiz | Brian Lawrence | Tim Worrell | Akinori Otsuka | Jose Valverde | 673 | 841 | -168 |
| 2005-09-25 | vs SDN | 156 | W 4-3 | 72-84 | 3 | 26,838 | Javier Vazquez | Woody Williams | Jose Valverde | Akinori Otsuka | | 677 | 844 | -167 |
| 2005-09-27 | @ LAN | 157 | W 2-0 | 73-84 | 3 | 42,604 | Brandon Webb | Jeff Weaver | Brandon Webb | Jeff Weaver | Jose Valverde | 679 | 844 | -165 |
| 2005-09-28 | @ LAN | 158 | W 4-3 | 74-84 | 2 | 46,424 | Shawn Estes | D.J. Houlton | Brandon Medders | Yhency Brazoban | Jose Valverde | 683 | 847 | -164 |
| 2005-09-29 | @ LAN | 159 | W 3-2 | 75-84 | 2 | 45,053 | Dustin Nippert | Odalis Perez | Dustin Nippert | Hong-Chih Kuo | Brandon Lyon | 686 | 849 | -163 |
| 2005-09-30 | @ SFN | 160 | W 7-3 | 76-84 | 2 | 38,893 | Claudio Vargas | Matt Cain | Oscar Villarreal | LaTroy Hawkins | Jose Valverde | 693 | 852 | -159 |
| 2005-10-01 | @ SFN | 161 | W 2-1 | 77-84 | 2 | 38,772 | Javier Vazquez | Brad Hennessey | Brandon Medders | Armando Benitez | Jose Valverde | 695 | 853 | -158 |
| 2005-10-02 | @ SFN | 162 | L 1-3 | 77-85 | 2 | 40,239 | Brandon Webb | Brett Tomko | Brett Tomko | Brandon Webb | | 696 | 856 | -160 |