| 2005-04-04 | @ CIN | 1 | L 6-7 | 0-1 | 4 | 42,794 | Pedro Martinez | Paul Wilson | Danny Graves | Braden Looper | | 6 | 7 | -1 |
| 2005-04-06 | @ CIN | 2 | L 5-9 | 0-2 | 5 | 22,301 | Tom Glavine | Eric Milton | Eric Milton | Tom Glavine | | 11 | 16 | -5 |
| 2005-04-07 | @ CIN | 3 | L 1-6 | 0-3 | 5 | 16,048 | Kazuhisa Ishii | Aaron Harang | Aaron Harang | Kazuhisa Ishii | Danny Graves | 12 | 22 | -10 |
| 2005-04-08 | @ ATL | 4 | L 1-3 | 0-4 | 5 | 50,939 | Victor Zambrano | John Thomson | John Thomson | Victor Zambrano | Danny Kolb | 13 | 25 | -12 |
| 2005-04-09 | @ ATL | 5 | L 3-6 | 0-5 | 5 | 40,604 | Aaron Heilman | Horacio Ramirez | Adam Bernero | Aaron Heilman | | 16 | 31 | -15 |
| 2005-04-10 | @ ATL | 6 | W 6-1 | 1-5 | 5 | 36,601 | Pedro Martinez | John Smoltz | Pedro Martinez | John Smoltz | | 22 | 32 | -10 |
| 2005-04-11 | vs HOU | 7 | W 8-4 | 2-5 | 5 | 53,663 | Tom Glavine | Andy Pettitte | Roberto Hernandez | Russ Springer | | 30 | 36 | -6 |
| 2005-04-13 | vs HOU | 8 | W 1-0 | 3-5 | 5 | 22,431 | Kazuhisa Ishii | Roger Clemens | Mike DeJean | Dan Wheeler | | 31 | 36 | -5 |
| 2005-04-14 | vs HOU | 9 | W 4-3 | 4-5 | 4 | 17,214 | Victor Zambrano | Brandon Backe | Mike Matthews | John Franco | Braden Looper | 35 | 39 | -4 |
| 2005-04-15 | vs FLO | 10 | W 4-0 | 5-5 | 4 | 49,448 | Aaron Heilman | Josh Beckett | Aaron Heilman | Josh Beckett | | 39 | 39 | 0 |
| 2005-04-16 | vs FLO | 11 | W 4-3 | 6-5 | 3 | 55,351 | Pedro Martinez | Al Leiter | Braden Looper | Guillermo Mota | | 43 | 42 | 1 |
| 2005-04-17 | vs FLO | 12 | L 2-5 | 6-6 | 4 | 55,266 | Tom Glavine | A.J. Burnett | A.J. Burnett | Tom Glavine | | 45 | 47 | -2 |
| 2005-04-18 | @ PHI | 13 | L 4-5 | 6-7 | 5 | 25,236 | Kazuhisa Ishii | Randy Wolf | Randy Wolf | Kazuhisa Ishii | Tim Worrell | 49 | 52 | -3 |
| 2005-04-19 | @ PHI | 14 | W 16-4 | 7-7 | 4 | 28,063 | Victor Zambrano | Vicente Padilla | Victor Zambrano | Vicente Padilla | | 65 | 56 | 9 |
| 2005-04-20 | @ FLO | 15 | L 2-9 | 7-8 | 4 | 21,339 | Aaron Heilman | Josh Beckett | Josh Beckett | Aaron Heilman | | 67 | 65 | 2 |
| 2005-04-21 | @ FLO | 16 | W 10-1 | 8-8 | 4 | 27,674 | Pedro Martinez | Al Leiter | Pedro Martinez | Al Leiter | | 77 | 66 | 11 |
| 2005-04-22 | vs WAS | 17 | W 3-1 | 9-8 | 3 | 28,488 | Tom Glavine | Esteban Loaiza | Tom Glavine | Esteban Loaiza | Braden Looper | 80 | 67 | 13 |
| 2005-04-23 | vs WAS | 18 | W 10-5 | 10-8 | 3 | 44,058 | Jae Weong Seo | Tomo Ohka | Jae Weong Seo | Tomo Ohka | | 90 | 72 | 18 |
| 2005-04-24 | vs WAS | 19 | L 4-11 | 10-9 | 3 | 43,313 | Victor Zambrano | Livan Hernandez | Livan Hernandez | Victor Zambrano | | 94 | 83 | 11 |
| 2005-04-25 | vs ATL | 20 | W 5-4 | 11-9 | 3 | 16,874 | Aaron Heilman | Horacio Ramirez | Aaron Heilman | Horacio Ramirez | Braden Looper | 99 | 87 | 12 |
| 2005-04-26 | vs ATL | 21 | L 3-4 | 11-10 | 3 | 31,511 | Pedro Martinez | John Smoltz | John Smoltz | Pedro Martinez | John Foster | 102 | 91 | 11 |
| 2005-04-27 | vs ATL | 22 | L 4-8 | 11-11 | 3 | 21,087 | Tom Glavine | Mike Hampton | Mike Hampton | Tom Glavine | | 106 | 99 | 7 |
| 2005-04-29 | @ WAS | 23 | L 1-5 | 11-12 | 4 | 30,627 | Jae Weong Seo | Livan Hernandez | Livan Hernandez | Jae Weong Seo | Chad Cordero | 107 | 104 | 3 |
| 2005-04-30 | @ WAS | 24 | L 3-5 | 11-13 | 4 | 40,913 | Victor Zambrano | Tomo Ohka | Tomo Ohka | Victor Zambrano | Hector Carrasco | 110 | 109 | 1 |
| 2005-05-01 | @ WAS | 25 | W 6-3 | 12-13 | 4 | 27,333 | Aaron Heilman | John Patterson | Roberto Hernandez | Luis Ayala | Braden Looper | 116 | 112 | 4 |
| 2005-05-02 | vs PHI | 26 | W 5-1 | 13-13 | 4 | 16,897 | Pedro Martinez | Jon Lieber | Pedro Martinez | Terry Adams | | 121 | 113 | 8 |
| 2005-05-03 | vs PHI | 27 | L 3-10 | 13-14 | 4 | 17,051 | Tom Glavine | Brett Myers | Brett Myers | Tom Glavine | | 124 | 123 | 1 |
| 2005-05-04 | vs PHI | 28 | W 3-2 | 14-14 | 4 | 21,356 | Jae Weong Seo | Randy Wolf | Jae Weong Seo | Randy Wolf | Braden Looper | 127 | 125 | 2 |
| 2005-05-05 | vs PHI | 29 | W 7-5 | 15-14 | 4 | 19,553 | Kris Benson | Vicente Padilla | Aaron Heilman | Vicente Padilla | Braden Looper | 134 | 130 | 4 |
| 2005-05-06 | @ MIL | 30 | W 7-4 | 16-14 | 4 | 21,067 | Victor Zambrano | Doug Davis | Victor Zambrano | Doug Davis | Braden Looper | 141 | 134 | 7 |
| 2005-05-07 | @ MIL | 31 | W 7-5 | 17-14 | 4 | 39,589 | Pedro Martinez | Wes Obermueller | Pedro Martinez | Julio Santana | Roberto Hernandez | 148 | 139 | 9 |
| 2005-05-08 | @ MIL | 32 | L 4-5 | 17-15 | 4 | 17,626 | Tom Glavine | Chris Capuano | Derrick Turnbow | Mike DeJean | | 152 | 144 | 8 |
| 2005-05-09 | @ CHN | 33 | W 7-4 | 18-15 | 4 | 37,562 | Aaron Heilman | Jon Leicester | Mike DeJean | LaTroy Hawkins | Braden Looper | 159 | 148 | 11 |
| 2005-05-10 | @ CHN | 34 | L 0-7 | 18-16 | 4 | 38,813 | Kris Benson | Greg Maddux | Greg Maddux | Kris Benson | | 159 | 155 | 4 |
| 2005-05-11 | @ CHN | 35 | L 3-4 | 18-17 | 4 | 38,475 | Victor Zambrano | Mark Prior | Ryan Dempster | Heath Bell | | 162 | 159 | 3 |
| 2005-05-13 | vs SLN | 36 | W 2-0 | 19-17 | 3 | 43,495 | Tom Glavine | Jason Marquis | Tom Glavine | Jason Marquis | Braden Looper | 164 | 159 | 5 |
| 2005-05-14 | vs SLN | 37 | L 6-7 | 19-18 | 4 | 40,921 | Pedro Martinez | Mark Mulder | Julian Tavarez | Roberto Hernandez | Jason Isringhausen | 170 | 166 | 4 |
| 2005-05-15 | vs SLN | 38 | L 2-4 | 19-19 | 4 | 32,949 | Aaron Heilman | Matt Morris | Matt Morris | Aaron Heilman | Jason Isringhausen | 172 | 170 | 2 |
| 2005-05-16 | vs CIN | 39 | W 9-2 | 20-19 | 4 | 19,963 | Kris Benson | Paul Wilson | Kris Benson | Paul Wilson | | 181 | 172 | 9 |
| 2005-05-17 | vs CIN | 40 | W 2-1 | 21-19 | 4 | 28,426 | Kazuhisa Ishii | Ramon Ortiz | Mike DeJean | Ramon Ortiz | Braden Looper | 183 | 173 | 10 |
| 2005-05-18 | vs CIN | 41 | W 10-6 | 22-19 | 4 | 26,607 | Tom Glavine | Eric Milton | Tom Glavine | Eric Milton | | 193 | 179 | 14 |
| 2005-05-20 | vs NYA | 42 | L 2-5 | 22-20 | 4 | 55,740 | Victor Zambrano | Kevin Brown | Kevin Brown | Victor Zambrano | Mariano Rivera | 195 | 184 | 11 |
| 2005-05-21 | vs NYA | 43 | W 7-1 | 23-20 | 3 | 55,800 | Kris Benson | Randy Johnson | Kris Benson | Randy Johnson | | 202 | 185 | 17 |
| 2005-05-22 | vs NYA | 44 | L 3-5 | 23-21 | 4 | 55,953 | Pedro Martinez | Carl Pavano | Carl Pavano | Roberto Hernandez | Mariano Rivera | 205 | 190 | 15 |
| 2005-05-23 | @ ATL | 45 | L 6-8 | 23-22 | 4 | 26,132 | Kazuhisa Ishii | Horacio Ramirez | Horacio Ramirez | Kazuhisa Ishii | Danny Kolb | 211 | 198 | 13 |
| 2005-05-24 | @ ATL | 46 | L 0-4 | 23-23 | 4 | 28,927 | Tom Glavine | Tim Hudson | Tim Hudson | Tom Glavine | | 211 | 202 | 9 |
| 2005-05-25 | @ ATL | 47 | L 0-3 | 23-24 | 4 | 33,250 | Victor Zambrano | Kyle Davies | Kyle Davies | Victor Zambrano | Chris Reitsma | 211 | 205 | 6 |
| 2005-05-26 | @ FLO | 48 | W 12-4 | 24-24 | 4 | 20,308 | Kris Benson | Frank Castillo | Kris Benson | Frank Castillo | | 223 | 209 | 14 |
| 2005-05-27 | @ FLO | 49 | W 1-0 | 25-24 | 3 | 25,891 | Pedro Martinez | Brian Moehler | Pedro Martinez | Brian Moehler | Braden Looper | 224 | 209 | 15 |
| 2005-05-28 | @ FLO | 50 | W 6-1 | 26-24 | 3 | 35,223 | Kazuhisa Ishii | Dontrelle Willis | Kazuhisa Ishii | Dontrelle Willis | | 230 | 210 | 20 |
| 2005-05-29 | @ FLO | 51 | L 3-6 | 26-25 | 3 | 30,214 | Tom Glavine | Josh Beckett | Josh Beckett | Heath Bell | Todd Jones | 233 | 216 | 17 |
| 2005-05-31 | vs ARI | 52 | L 0-7 | 26-26 | 4 | 33,955 | Kris Benson | Brad Halsey | Brad Halsey | Kris Benson | | 233 | 223 | 10 |
| 2005-06-01 | vs ARI | 53 | W 2-1 | 27-26 | 3 | 33,436 | Victor Zambrano | Brandon Webb | Victor Zambrano | Brandon Webb | Braden Looper | 235 | 224 | 11 |
| 2005-06-02 | vs ARI | 54 | W 6-1 | 28-26 | 3 | 28,260 | Pedro Martinez | Shawn Estes | Pedro Martinez | Shawn Estes | | 241 | 225 | 16 |
| 2005-06-04 | vs SFN | 55 | W 5-1 | 29-26 | 4 | 37,194 | Tom Glavine | Noah Lowry | Tom Glavine | Noah Lowry | | 246 | 226 | 20 |
| 2005-06-05 | vs SFN | 56 | L 3-6 | 30-27 | 3 | 0 | Kazuhisa Ishii | Brett Tomko | Brett Tomko | Kazuhisa Ishii | Tyler Walker | 249 | 232 | 17 |
| 2005-06-05 | vs SFN | 57 | W 12-1 | 30-27 | 3 | 33,460 | Kris Benson | Jason Schmidt | Kris Benson | Jason Schmidt | | 261 | 233 | 28 |
| 2005-06-07 | vs HOU | 58 | W 3-1 | 31-27 | 3 | 39,953 | Pedro Martinez | Roy Oswalt | Pedro Martinez | Roy Oswalt | | 264 | 234 | 30 |
| 2005-06-08 | vs HOU | 59 | L 1-4 | 31-28 | 4 | 23,635 | Victor Zambrano | Brandon Backe | Brandon Backe | Victor Zambrano | Brad Lidge | 265 | 238 | 27 |
| 2005-06-09 | vs HOU | 60 | L 3-6 | 31-29 | 4 | 30,737 | Tom Glavine | Andy Pettitte | Russ Springer | Heath Bell | Brad Lidge | 268 | 244 | 24 |
| 2005-06-10 | vs ANA | 61 | L 2-12 | 31-30 | 5 | 31,131 | Kazuhisa Ishii | Bartolo Colon | Bartolo Colon | Kazuhisa Ishii | | 270 | 256 | 14 |
| 2005-06-11 | vs ANA | 62 | W 5-3 | 32-30 | 5 | 33,889 | Kris Benson | Jarrod Washburn | Braden Looper | Brendan Donnelly | | 275 | 259 | 16 |
| 2005-06-12 | vs ANA | 63 | L 3-4 | 32-31 | 5 | 43,582 | Pedro Martinez | John Lackey | Scot Shields | Braden Looper | Francisco Rodriguez | 278 | 263 | 15 |
| 2005-06-14 | @ OAK | 64 | L 0-5 | 32-32 | 5 | 18,744 | Tom Glavine | Joe Blanton | Joe Blanton | Tom Glavine | Huston Street | 278 | 268 | 10 |
| 2005-06-15 | @ OAK | 65 | L 2-3 | 32-33 | 5 | 27,598 | Victor Zambrano | Dan Haren | Justin Duchscherer | Royce Ring | | 280 | 271 | 9 |
| 2005-06-16 | @ OAK | 66 | W 9-6 | 33-33 | 5 | 17,308 | Kris Benson | Ryan Glynn | Kris Benson | Ryan Glynn | Braden Looper | 289 | 277 | 12 |
| 2005-06-17 | @ SEA | 67 | L 0-5 | 33-34 | 5 | 37,443 | Kazuhisa Ishii | Jamie Moyer | Jamie Moyer | Kazuhisa Ishii | Jeff Nelson | 289 | 282 | 7 |
| 2005-06-18 | @ SEA | 68 | L 1-4 | 33-35 | 5 | 45,841 | Pedro Martinez | Ryan Franklin | Ryan Franklin | Pedro Martinez | Eddie Guardado | 290 | 286 | 4 |
| 2005-06-19 | @ SEA | 69 | L 5-11 | 33-36 | 5 | 45,785 | Tom Glavine | Gil Meche | Gil Meche | Tom Glavine | | 295 | 297 | -2 |
| 2005-06-21 | @ PHI | 70 | W 8-5 | 34-36 | 5 | 43,050 | Kris Benson | Brett Myers | Kris Benson | Brett Myers | Braden Looper | 303 | 302 | 1 |
| 2005-06-22 | @ PHI | 71 | L 4-8 | 34-37 | 5 | 42,640 | Victor Zambrano | Rob Tejeda | Ryan Madson | Royce Ring | | 307 | 310 | -3 |
| 2005-06-23 | @ PHI | 72 | W 4-3 | 35-37 | 5 | 45,449 | Kazuhisa Ishii | Cory Lidle | Kazuhisa Ishii | Cory Lidle | Braden Looper | 311 | 313 | -2 |
| 2005-06-24 | @ NYA | 73 | W 6-4 | 36-37 | 5 | 55,297 | Pedro Martinez | Mike Mussina | Pedro Martinez | Mike Mussina | | 317 | 317 | 0 |
| 2005-06-25 | @ NYA | 74 | W 10-3 | 37-37 | 5 | 55,114 | Tom Glavine | Sean Henn | Tom Glavine | Sean Henn | | 327 | 320 | 7 |
| 2005-06-26 | @ NYA | 75 | L 4-5 | 37-38 | 5 | 55,327 | Kris Benson | Randy Johnson | Mariano Rivera | Braden Looper | | 331 | 325 | 6 |
| 2005-06-28 | vs PHI | 76 | W 8-3 | 38-38 | 5 | 39,898 | Victor Zambrano | Rob Tejeda | Victor Zambrano | Rob Tejeda | | 339 | 328 | 11 |
| 2005-06-29 | vs PHI | 77 | L 3-6 | 38-39 | 5 | 24,915 | Kazuhisa Ishii | Cory Lidle | Cory Lidle | Kazuhisa Ishii | Billy Wagner | 342 | 334 | 8 |
| 2005-06-30 | vs PHI | 78 | W 5-3 | 39-39 | 5 | 36,667 | Pedro Martinez | Jon Lieber | Pedro Martinez | Jon Lieber | Braden Looper | 347 | 337 | 10 |
| 2005-07-01 | vs FLO | 79 | W 7-6 | 40-39 | 4 | 44,853 | Tom Glavine | A.J. Burnett | Roberto Hernandez | Jim Mecir | Braden Looper | 354 | 343 | 11 |
| 2005-07-02 | vs FLO | 80 | L 3-7 | 40-40 | 5 | 41,290 | Kris Benson | Brian Moehler | Brian Moehler | Kris Benson | | 357 | 350 | 7 |
| 2005-07-03 | vs FLO | 81 | L 0-3 | 40-41 | 5 | 37,824 | Victor Zambrano | Dontrelle Willis | Dontrelle Willis | Victor Zambrano | | 357 | 353 | 4 |
| 2005-07-04 | @ WAS | 82 | W 5-2 | 41-41 | 5 | 44,331 | Kazuhisa Ishii | John Patterson | Roberto Hernandez | Sun-Woo Kim | Braden Looper | 362 | 355 | 7 |
| 2005-07-05 | @ WAS | 83 | L 2-3 | 41-42 | 5 | 35,087 | Pedro Martinez | Esteban Loaiza | Esteban Loaiza | Pedro Martinez | Chad Cordero | 364 | 358 | 6 |
| 2005-07-06 | @ WAS | 84 | W 5-3 | 42-42 | 5 | 38,148 | Tom Glavine | Livan Hernandez | Tom Glavine | Livan Hernandez | Braden Looper | 369 | 361 | 8 |
| 2005-07-07 | @ WAS | 85 | W 3-2 | 43-42 | 4 | 44,492 | Kris Benson | Tony Armas | Heath Bell | Luis Ayala | Braden Looper | 372 | 363 | 9 |
| 2005-07-08 | @ PIT | 86 | L 5-6 | 43-43 | 4 | 32,563 | Victor Zambrano | Josh Fogg | Jose Mesa | Braden Looper | | 377 | 369 | 8 |
| 2005-07-09 | @ PIT | 87 | L 4-11 | 43-44 | 5 | 36,708 | Kazuhisa Ishii | David Williams | David Williams | Kazuhisa Ishii | | 381 | 380 | 1 |
| 2005-07-10 | @ PIT | 88 | W 6-1 | 44-44 | 5 | 26,551 | Pedro Martinez | Kip Wells | Pedro Martinez | Kip Wells | | 387 | 381 | 6 |
| 2005-07-14 | vs ATL | 89 | W 6-3 | 45-44 | 5 | 43,319 | Kris Benson | Horacio Ramirez | Roberto Hernandez | Jim Brower | Braden Looper | 393 | 384 | 9 |
| 2005-07-15 | vs ATL | 90 | L 1-2 | 45-45 | 5 | 34,444 | Tom Glavine | John Smoltz | John Smoltz | Roberto Hernandez | Chris Reitsma | 394 | 386 | 8 |
| 2005-07-16 | vs ATL | 91 | L 0-3 | 45-46 | 5 | 36,078 | Victor Zambrano | Tim Hudson | Tim Hudson | Victor Zambrano | Chris Reitsma | 394 | 389 | 5 |
| 2005-07-17 | vs ATL | 92 | W 8-1 | 46-46 | 5 | 34,983 | Pedro Martinez | Mike Hampton | Pedro Martinez | Mike Hampton | | 402 | 390 | 12 |
| 2005-07-19 | vs SDN | 93 | W 3-1 | 47-46 | 4 | 37,945 | Kris Benson | Brian Lawrence | Braden Looper | Chris Hammond | | 405 | 391 | 14 |
| 2005-07-20 | vs SDN | 94 | W 7-3 | 48-46 | 4 | 31,697 | Tom Glavine | Woody Williams | Tom Glavine | Woody Williams | Juan Padilla | 412 | 394 | 18 |
| 2005-07-21 | vs SDN | 95 | W 12-0 | 49-46 | 3 | 33,361 | Kazuhisa Ishii | Jake Peavy | Kazuhisa Ishii | Jake Peavy | | 424 | 394 | 30 |
| 2005-07-22 | vs LAN | 96 | L 5-6 | 49-47 | 4 | 50,273 | Victor Zambrano | Jeff Weaver | Jeff Weaver | Victor Zambrano | Yhency Brazoban | 429 | 400 | 29 |
| 2005-07-23 | vs LAN | 97 | W 7-5 | 50-47 | 4 | 43,705 | Pedro Martinez | D.J. Houlton | Pedro Martinez | Giovanni Carrara | Braden Looper | 436 | 405 | 31 |
| 2005-07-24 | vs LAN | 98 | W 6-0 | 51-47 | 4 | 38,008 | Kris Benson | Brad Penny | Kris Benson | Brad Penny | | 442 | 405 | 37 |
| 2005-07-25 | @ COL | 99 | L 3-5 | 51-48 | 4 | 22,216 | Tom Glavine | Jose Acevedo | Jose Acevedo | Tom Glavine | Brian Fuentes | 445 | 410 | 35 |
| 2005-07-26 | @ COL | 100 | L 3-4 | 51-49 | 4 | 22,518 | Kazuhisa Ishii | Jeff Francis | Jeff Francis | Kazuhisa Ishii | Brian Fuentes | 448 | 414 | 34 |
| 2005-07-27 | @ COL | 101 | W 9-3 | 52-49 | 3 | 26,183 | Victor Zambrano | Jamey Wright | Victor Zambrano | Jamey Wright | | 457 | 417 | 40 |
| 2005-07-28 | @ HOU | 102 | L 2-3 | 52-50 | 5 | 43,552 | Pedro Martinez | Ezequiel Astacio | Dan Wheeler | Roberto Hernandez | | 459 | 420 | 39 |
| 2005-07-29 | @ HOU | 103 | L 2-5 | 52-51 | 5 | 42,659 | Kris Benson | Wandy Rodriguez | Wandy Rodriguez | Kris Benson | Brad Lidge | 461 | 425 | 36 |
| 2005-07-30 | @ HOU | 104 | L 0-2 | 52-52 | 5 | 43,596 | Tom Glavine | Andy Pettitte | Andy Pettitte | Tom Glavine | Brad Lidge | 461 | 427 | 34 |
| 2005-07-31 | @ HOU | 105 | W 9-4 | 53-52 | 5 | 43,028 | Kazuhisa Ishii | Roy Oswalt | Aaron Heilman | Dan Wheeler | | 470 | 431 | 39 |
| 2005-08-02 | vs MIL | 106 | W 9-8 | 54-52 | 5 | 32,453 | Victor Zambrano | Tomo Ohka | Braden Looper | Julio Santana | | 479 | 439 | 40 |
| 2005-08-03 | vs MIL | 107 | L 4-6 | 54-53 | 5 | 40,659 | Pedro Martinez | Victor Santos | Rick Helling | Braden Looper | Derrick Turnbow | 483 | 445 | 38 |
| 2005-08-04 | vs MIL | 108 | L 9-12 | 54-54 | 5 | 30,359 | Kris Benson | Doug Davis | Julio Santana | Roberto Hernandez | Derrick Turnbow | 492 | 457 | 35 |
| 2005-08-05 | vs CHN | 109 | W 9-5 | 55-54 | 5 | 34,728 | Tom Glavine | Rich Hill | Tom Glavine | Rich Hill | | 501 | 462 | 39 |
| 2005-08-06 | vs CHN | 110 | W 2-0 | 56-54 | 5 | 39,911 | Jae Weong Seo | Greg Maddux | Jae Weong Seo | Greg Maddux | Braden Looper | 503 | 462 | 41 |
| 2005-08-07 | vs CHN | 111 | W 6-1 | 57-54 | 5 | 40,321 | Victor Zambrano | Carlos Zambrano | Victor Zambrano | Carlos Zambrano | | 509 | 463 | 46 |
| 2005-08-09 | @ SDN | 112 | L 3-8 | 57-55 | 5 | 41,977 | Pedro Martinez | Chan Ho Park | Chan Ho Park | Pedro Martinez | | 512 | 471 | 41 |
| 2005-08-10 | @ SDN | 113 | W 9-1 | 58-55 | 5 | 43,162 | Kris Benson | Brian Lawrence | Kris Benson | Brian Lawrence | | 521 | 472 | 49 |
| 2005-08-11 | @ SDN | 114 | L 1-2 | 58-56 | 5 | 35,148 | Tom Glavine | Woody Williams | Woody Williams | Tom Glavine | Trevor Hoffman | 522 | 474 | 48 |
| 2005-08-12 | @ LAN | 115 | L 6-7 | 58-57 | 5 | 54,361 | Victor Zambrano | Jeff Weaver | Duaner Sanchez | Braden Looper | | 528 | 481 | 47 |
| 2005-08-13 | @ LAN | 116 | W 5-1 | 59-57 | 5 | 47,096 | Jae Weong Seo | D.J. Houlton | Jae Weong Seo | D.J. Houlton | | 533 | 482 | 51 |
| 2005-08-14 | @ LAN | 117 | L 1-2 | 59-58 | 5 | 48,055 | Pedro Martinez | Brad Penny | Brad Penny | Pedro Martinez | | 534 | 484 | 50 |
| 2005-08-16 | vs PIT | 118 | W 6-2 | 60-58 | 5 | 37,202 | Kris Benson | Mark Redman | Kris Benson | Mark Redman | | 540 | 486 | 54 |
| 2005-08-17 | vs PIT | 119 | W 5-1 | 61-58 | 5 | 28,730 | Tom Glavine | Josh Fogg | Tom Glavine | Josh Fogg | Aaron Heilman | 545 | 487 | 58 |
| 2005-08-18 | vs PIT | 120 | L 0-5 | 61-59 | 5 | 35,653 | Victor Zambrano | Zach Duke | Zach Duke | Victor Zambrano | | 545 | 492 | 53 |
| 2005-08-19 | vs WAS | 121 | W 1-0 | 62-59 | 5 | 38,196 | Jae Weong Seo | John Patterson | Jae Weong Seo | John Patterson | Braden Looper | 546 | 492 | 54 |
| 2005-08-20 | vs WAS | 122 | W 9-8 | 63-59 | 5 | 51,785 | Pedro Martinez | Livan Hernandez | Roberto Hernandez | Gary Majewski | | 555 | 500 | 55 |
| 2005-08-21 | vs WAS | 123 | L 4-7 | 63-60 | 5 | 42,412 | Kris Benson | Esteban Loaiza | Esteban Loaiza | Kris Benson | | 559 | 507 | 52 |
| 2005-08-22 | @ ARI | 124 | W 4-1 | 64-60 | 5 | 23,371 | Tom Glavine | Brandon Webb | Tom Glavine | Brandon Webb | Braden Looper | 563 | 508 | 55 |
| 2005-08-23 | @ ARI | 125 | W 14-1 | 65-60 | 4 | 24,699 | Victor Zambrano | Claudio Vargas | Victor Zambrano | Claudio Vargas | | 577 | 509 | 68 |
| 2005-08-24 | @ ARI | 126 | W 18-4 | 66-60 | 4 | 22,268 | Jae Weong Seo | Russ Ortiz | Jae Weong Seo | Russ Ortiz | | 595 | 513 | 82 |
| 2005-08-25 | @ ARI | 127 | W 3-1 | 67-60 | 4 | 21,683 | Pedro Martinez | Javier Vazquez | Pedro Martinez | Javier Vazquez | Braden Looper | 598 | 514 | 84 |
| 2005-08-26 | @ SFN | 128 | W 1-0 | 68-60 | 4 | 39,591 | Steve Trachsel | Kevin Correia | Steve Trachsel | Kevin Correia | Braden Looper | 599 | 514 | 85 |
| 2005-08-27 | @ SFN | 129 | L 1-2 | 68-61 | 4 | 42,180 | Tom Glavine | Jason Schmidt | Jason Schmidt | Tom Glavine | Armando Benitez | 600 | 516 | 84 |
| 2005-08-28 | @ SFN | 130 | L 1-4 | 68-62 | 4 | 41,659 | Kris Benson | Noah Lowry | Noah Lowry | Kris Benson | Armando Benitez | 601 | 520 | 81 |
| 2005-08-30 | vs PHI | 131 | W 6-4 | 69-62 | 4 | 36,505 | Jae Weong Seo | Rob Tejeda | Juan Padilla | Ugueth Urbina | Braden Looper | 607 | 524 | 83 |
| 2005-08-31 | vs PHI | 132 | L 2-8 | 69-63 | 4 | 43,780 | Pedro Martinez | Brett Myers | Brett Myers | Pedro Martinez | | 609 | 532 | 77 |
| 2005-09-01 | vs PHI | 133 | L 1-3 | 69-64 | 4 | 38,316 | Tom Glavine | Jon Lieber | Jon Lieber | Tom Glavine | Billy Wagner | 610 | 535 | 75 |
| 2005-09-02 | @ FLO | 134 | L 2-4 | 69-65 | 4 | 25,916 | Victor Zambrano | Dontrelle Willis | Dontrelle Willis | Victor Zambrano | Todd Jones | 612 | 539 | 73 |
| 2005-09-03 | @ FLO | 135 | L 4-5 | 69-66 | 5 | 37,336 | Kris Benson | Josh Beckett | Ron Villone | Juan Padilla | Todd Jones | 616 | 544 | 72 |
| 2005-09-04 | @ FLO | 136 | W 7-1 | 70-66 | 5 | 23,848 | Jae Weong Seo | A.J. Burnett | Jae Weong Seo | A.J. Burnett | | 623 | 545 | 78 |
| 2005-09-05 | @ ATL | 137 | L 2-4 | 70-67 | 5 | 33,045 | Steve Trachsel | John Thomson | Blaine Boyer | Steve Trachsel | Kyle Farnsworth | 625 | 549 | 76 |
| 2005-09-06 | @ ATL | 138 | L 1-3 | 70-68 | 5 | 21,068 | Pedro Martinez | John Smoltz | John Smoltz | Pedro Martinez | Kyle Farnsworth | 626 | 552 | 74 |
| 2005-09-07 | @ ATL | 139 | L 3-4 | 70-69 | 5 | 28,564 | Tom Glavine | Tim Hudson | John Foster | Braden Looper | | 629 | 556 | 73 |
| 2005-09-08 | @ SLN | 140 | L 0-5 | 70-70 | 5 | 47,422 | Kris Benson | Chris Carpenter | Chris Carpenter | Kris Benson | | 629 | 561 | 68 |
| 2005-09-09 | @ SLN | 141 | L 2-3 | 70-71 | 5 | 45,616 | Jae Weong Seo | Jason Marquis | Jason Marquis | Jae Weong Seo | Jason Isringhausen | 631 | 564 | 67 |
| 2005-09-10 | @ SLN | 142 | L 2-4 | 70-72 | 5 | 48,465 | Steve Trachsel | Jeff Suppan | Jeff Suppan | Steve Trachsel | Jason Isringhausen | 633 | 568 | 65 |
| 2005-09-11 | @ SLN | 143 | W 7-2 | 71-72 | 5 | 45,884 | Pedro Martinez | Matt Morris | Pedro Martinez | Matt Morris | | 640 | 570 | 70 |
| 2005-09-13 | vs WAS | 144 | L 2-4 | 71-73 | 5 | 34,143 | Tom Glavine | Hector Carrasco | Gary Majewski | Tom Glavine | Chad Cordero | 642 | 574 | 68 |
| 2005-09-14 | vs WAS | 145 | L 3-6 | 71-74 | 5 | 24,049 | Kris Benson | Esteban Loaiza | Esteban Loaiza | Kris Benson | Chad Cordero | 645 | 580 | 65 |
| 2005-09-15 | vs WAS | 146 | L 5-6 | 71-75 | 5 | 21,441 | Jae Weong Seo | Livan Hernandez | Jason Bergmann | Roberto Hernandez | Gary Majewski | 650 | 586 | 64 |
| 2005-09-16 | vs ATL | 147 | W 4-0 | 72-75 | 5 | 37,519 | Pedro Martinez | John Smoltz | Pedro Martinez | John Smoltz | | 654 | 586 | 68 |
| 2005-09-17 | vs ATL | 148 | L 4-7 | 72-76 | 5 | 34,191 | Steve Trachsel | Tim Hudson | Tim Hudson | Steve Trachsel | Kyle Farnsworth | 658 | 593 | 65 |
| 2005-09-18 | vs ATL | 149 | W 4-1 | 73-76 | 5 | 31,703 | Tom Glavine | John Thomson | Tom Glavine | John Thomson | | 662 | 594 | 68 |
| 2005-09-20 | vs FLO | 150 | W 3-2 | 74-76 | 5 | 21,275 | Kris Benson | A.J. Burnett | Aaron Heilman | Brian Moehler | | 665 | 596 | 69 |
| 2005-09-21 | vs FLO | 151 | W 5-4 | 75-76 | 5 | 36,793 | Jae Weong Seo | Jason Vargas | Roberto Hernandez | Paul Quantrill | | 670 | 600 | 70 |
| 2005-09-22 | vs FLO | 152 | L 1-2 | 75-77 | 5 | 25,093 | Pedro Martinez | Dontrelle Willis | Dontrelle Willis | Pedro Martinez | Todd Jones | 671 | 602 | 69 |
| 2005-09-23 | @ WAS | 153 | W 5-2 | 76-77 | 5 | 30,194 | Steve Trachsel | Esteban Loaiza | Roberto Hernandez | Gary Majewski | Aaron Heilman | 676 | 604 | 72 |
| 2005-09-24 | @ WAS | 154 | W 5-2 | 77-77 | 5 | 32,467 | Tom Glavine | Livan Hernandez | Tom Glavine | Livan Hernandez | Roberto Hernandez | 681 | 606 | 75 |
| 2005-09-25 | @ WAS | 155 | W 6-5 | 78-77 | 4 | 29,967 | Kris Benson | John Patterson | Juan Padilla | Travis Hughes | Aaron Heilman | 687 | 611 | 76 |
| 2005-09-26 | @ PHI | 156 | W 6-5 | 79-77 | 4 | 28,679 | Jae Weong Seo | Brett Myers | Shingo Takatsu | Ugueth Urbina | Roberto Hernandez | 693 | 616 | 77 |
| 2005-09-27 | @ PHI | 157 | W 3-2 | 80-77 | 3 | 36,150 | Victor Zambrano | Jon Lieber | Juan Padilla | Jon Lieber | Aaron Heilman | 696 | 618 | 78 |
| 2005-09-28 | @ PHI | 158 | L 6-16 | 80-78 | 4 | 42,250 | Steve Trachsel | Vicente Padilla | Vicente Padilla | Steve Trachsel | | 702 | 634 | 68 |
| 2005-09-29 | vs COL | 159 | W 11-0 | 81-78 | 3 | 27,570 | Tom Glavine | Sun-Woo Kim | Tom Glavine | Sun-Woo Kim | | 713 | 634 | 79 |
| 2005-09-30 | vs COL | 160 | W 3-2 | 82-78 | 3 | 29,133 | Kris Benson | Byung-Hyun Kim | Kris Benson | Byung-Hyun Kim | Aaron Heilman | 716 | 636 | 80 |
| 2005-10-01 | vs COL | 161 | W 3-1 | 83-78 | 3 | 36,385 | Jae Weong Seo | Mike Esposito | Jae Weong Seo | Mike Esposito | Roberto Hernandez | 719 | 637 | 82 |
| 2005-10-02 | vs COL | 162 | L 3-11 | 83-79 | 4 | 47,718 | Victor Zambrano | Aaron Cook | Aaron Cook | Victor Zambrano | | 722 | 648 | 74 |