| 2005-04-04 | @ PIT | 1 | W 9-2 | 1-0 | 3 | 38,016 | Ben Sheets | Oliver Perez | Ben Sheets | Oliver Perez | | 9 | 2 | 7 |
| 2005-04-06 | @ PIT | 2 | W 10-2 | 2-0 | 2 | 12,077 | Doug Davis | Kip Wells | Doug Davis | Kip Wells | | 19 | 4 | 15 |
| 2005-04-08 | @ CHN | 3 | W 6-3 | 3-0 | 1 | 39,892 | Chris Capuano | Kerry Wood | Jorge de la Rosa | Jon Leicester | Mike Adams | 25 | 7 | 18 |
| 2005-04-09 | @ CHN | 4 | L 0-4 | 3-1 | 2 | 38,743 | Ben Sheets | Carlos Zambrano | Carlos Zambrano | Ben Sheets | | 25 | 11 | 14 |
| 2005-04-10 | @ CHN | 5 | L 5-6 | 3-2 | 2 | 39,076 | Victor Santos | Greg Maddux | Glendon Rusch | Derrick Turnbow | | 30 | 17 | 13 |
| 2005-04-11 | vs PIT | 6 | W 6-2 | 4-2 | 2 | 42,458 | Doug Davis | Kip Wells | Doug Davis | Kip Wells | | 36 | 19 | 17 |
| 2005-04-12 | vs PIT | 7 | L 2-4 | 4-3 | 2 | 10,927 | Gary Glover | Mark Redman | Mark Redman | Gary Glover | Jose Mesa | 38 | 23 | 15 |
| 2005-04-13 | vs PIT | 8 | W 6-2 | 5-3 | 1 | 11,021 | Chris Capuano | Josh Fogg | Jorge de la Rosa | Rick White | | 44 | 25 | 19 |
| 2005-04-15 | vs SLN | 9 | L 0-3 | 5-4 | 2 | 22,676 | Ben Sheets | Jeff Suppan | Jeff Suppan | Ben Sheets | Jason Isringhausen | 44 | 28 | 16 |
| 2005-04-16 | vs SLN | 10 | L 3-5 | 5-5 | 4 | 30,732 | Doug Davis | Chris Carpenter | Chris Carpenter | Doug Davis | Jason Isringhausen | 47 | 33 | 14 |
| 2005-04-17 | vs SLN | 11 | L 2-3 | 5-6 | 5 | 21,144 | Victor Santos | Jason Marquis | Jason Marquis | Mike Adams | Jason Isringhausen | 49 | 36 | 13 |
| 2005-04-18 | vs LAN | 12 | L 3-7 | 5-7 | 5 | 11,728 | Chris Capuano | Odalis Perez | Odalis Perez | Chris Capuano | | 52 | 43 | 9 |
| 2005-04-19 | vs LAN | 13 | L 6-8 | 5-8 | 5 | 11,029 | Gary Glover | Elmer Dessens | Giovanni Carrara | Tommy Phelps | Yhency Brazoban | 58 | 51 | 7 |
| 2005-04-20 | @ HOU | 14 | L 1-6 | 5-9 | 5 | 26,119 | Ben Sheets | Roy Oswalt | Roy Oswalt | Ben Sheets | | 59 | 57 | 2 |
| 2005-04-21 | @ HOU | 15 | L 7-8 | 5-10 | 5 | 32,173 | Doug Davis | Andy Pettitte | Andy Pettitte | Doug Davis | Brad Lidge | 66 | 65 | 1 |
| 2005-04-22 | @ SFN | 16 | W 6-1 | 6-10 | 5 | 36,994 | Victor Santos | Kirk Rueter | Victor Santos | Kirk Rueter | | 72 | 66 | 6 |
| 2005-04-23 | @ SFN | 17 | L 2-6 | 6-11 | 5 | 37,341 | Chris Capuano | Brett Tomko | Brett Tomko | Chris Capuano | Armando Benitez | 74 | 72 | 2 |
| 2005-04-24 | @ SFN | 18 | W 8-5 | 7-11 | 5 | 36,604 | Gary Glover | Jerome Williams | Gary Glover | Jerome Williams | Derrick Turnbow | 82 | 77 | 5 |
| 2005-04-26 | @ SLN | 19 | L 3-5 | 7-12 | 5 | 28,787 | Doug Davis | Jeff Suppan | Jeff Suppan | Doug Davis | Randy Flores | 85 | 82 | 3 |
| 2005-04-27 | @ SLN | 20 | L 3-6 | 7-13 | 6 | 38,343 | Victor Santos | Chris Carpenter | Chris Carpenter | Victor Santos | Julian Tavarez | 88 | 88 | 0 |
| 2005-04-28 | @ SLN | 21 | W 4-3 | 8-13 | 6 | 26,026 | Chris Capuano | Jason Marquis | Chris Capuano | Jason Marquis | Derrick Turnbow | 92 | 91 | 1 |
| 2005-04-29 | vs CIN | 22 | W 4-3 | 9-13 | 4 | 21,332 | Gary Glover | Brandon Claussen | Gary Glover | Brandon Claussen | Derrick Turnbow | 96 | 94 | 2 |
| 2005-04-30 | vs CIN | 23 | W 6-5 | 10-13 | 4 | 23,880 | Wes Obermueller | Paul Wilson | Derrick Turnbow | Joe Valentine | | 102 | 99 | 3 |
| 2005-05-01 | vs CIN | 24 | W 13-3 | 11-13 | 3 | 23,036 | Doug Davis | Ramon Ortiz | Doug Davis | Ramon Ortiz | | 115 | 102 | 13 |
| 2005-05-03 | vs CHN | 25 | W 4-1 | 12-13 | 3 | 27,079 | Chris Capuano | Carlos Zambrano | Chris Capuano | Carlos Zambrano | Derrick Turnbow | 119 | 103 | 16 |
| 2005-05-04 | vs CHN | 26 | W 4-3 | 13-13 | 2 | 28,392 | Victor Santos | Ryan Dempster | Derrick Turnbow | Roberto Novoa | | 123 | 106 | 17 |
| 2005-05-05 | vs CHN | 27 | W 6-5 | 14-13 | 2 | 31,721 | Gary Glover | Greg Maddux | Derrick Turnbow | LaTroy Hawkins | | 129 | 111 | 18 |
| 2005-05-06 | vs NYN | 28 | L 4-7 | 14-14 | 2 | 21,067 | Doug Davis | Victor Zambrano | Victor Zambrano | Doug Davis | Braden Looper | 133 | 118 | 15 |
| 2005-05-07 | vs NYN | 29 | L 5-7 | 14-15 | 2 | 39,589 | Wes Obermueller | Pedro Martinez | Pedro Martinez | Julio Santana | Roberto Hernandez | 138 | 125 | 13 |
| 2005-05-08 | vs NYN | 30 | W 5-4 | 15-15 | 2 | 17,626 | Chris Capuano | Tom Glavine | Derrick Turnbow | Mike DeJean | | 143 | 129 | 14 |
| 2005-05-09 | vs PHI | 31 | L 2-4 | 15-16 | 2 | 11,103 | Victor Santos | Randy Wolf | Randy Wolf | Victor Santos | Billy Wagner | 145 | 133 | 12 |
| 2005-05-10 | vs PHI | 32 | W 8-5 | 16-16 | 2 | 12,082 | Gary Glover | Vicente Padilla | Julio Santana | Terry Adams | Ricky Bottalico | 153 | 138 | 15 |
| 2005-05-11 | vs PHI | 33 | W 5-2 | 17-16 | 2 | 13,175 | Doug Davis | Cory Lidle | Doug Davis | Cory Lidle | Derrick Turnbow | 158 | 140 | 18 |
| 2005-05-13 | @ PIT | 34 | W 4-3 | 18-16 | 2 | 23,845 | Chris Capuano | Kip Wells | Chris Capuano | Jose Mesa | Derrick Turnbow | 162 | 143 | 19 |
| 2005-05-14 | @ PIT | 35 | L 0-2 | 18-17 | 2 | 21,772 | Victor Santos | Mark Redman | Mark Redman | Victor Santos | | 162 | 145 | 17 |
| 2005-05-15 | @ PIT | 36 | L 2-4 | 18-18 | 2 | 15,134 | Gary Glover | David Williams | David Williams | Gary Glover | Jose Mesa | 164 | 149 | 15 |
| 2005-05-16 | @ WAS | 37 | L 2-5 | 18-19 | 2 | 26,606 | Doug Davis | Tony Armas | Tony Armas | Doug Davis | Luis Ayala | 166 | 154 | 12 |
| 2005-05-17 | @ WAS | 38 | W 8-2 | 19-19 | 2 | 26,427 | Wes Obermueller | Claudio Vargas | Wes Obermueller | Claudio Vargas | | 174 | 156 | 18 |
| 2005-05-18 | @ WAS | 39 | L 0-1 | 19-20 | 2 | 29,216 | Chris Capuano | Esteban Loaiza | Gary Majewski | Chris Capuano | | 174 | 157 | 17 |
| 2005-05-19 | @ WAS | 40 | L 2-3 | 19-21 | 2 | 30,968 | Victor Santos | Livan Hernandez | Livan Hernandez | Victor Santos | Chad Cordero | 176 | 160 | 16 |
| 2005-05-20 | @ MIN | 41 | L 1-7 | 19-22 | 2 | 30,073 | Gary Glover | Carlos Silva | Carlos Silva | Gary Glover | | 177 | 167 | 10 |
| 2005-05-21 | @ MIN | 42 | W 6-0 | 20-22 | 2 | 32,106 | Doug Davis | Brad Radke | Doug Davis | Brad Radke | | 183 | 167 | 16 |
| 2005-05-22 | @ MIN | 43 | L 5-6 | 20-23 | 2 | 28,466 | Wes Obermueller | Johan Santana | Jesse Crain | Matt Wise | | 188 | 173 | 15 |
| 2005-05-23 | vs COL | 44 | W 2-1 | 21-23 | 2 | 11,855 | Chris Capuano | Shawn Chacon | Chris Capuano | Shawn Chacon | Ricky Bottalico | 190 | 174 | 16 |
| 2005-05-24 | vs COL | 45 | W 6-1 | 22-23 | 2 | 17,759 | Victor Santos | Jeff Francis | Victor Santos | Jeff Francis | | 196 | 175 | 21 |
| 2005-05-25 | vs COL | 46 | W 11-1 | 23-23 | 2 | 24,916 | Gary Glover | Jamey Wright | Gary Glover | Jamey Wright | | 207 | 176 | 31 |
| 2005-05-27 | vs HOU | 47 | W 3-0 | 24-23 | 2 | 22,173 | Doug Davis | Roy Oswalt | Doug Davis | Roy Oswalt | Derrick Turnbow | 210 | 176 | 34 |
| 2005-05-28 | vs HOU | 48 | L 6-9 | 24-24 | 2 | 37,845 | Ben Sheets | Wandy Rodriguez | Wandy Rodriguez | Ben Sheets | Brad Lidge | 216 | 185 | 31 |
| 2005-05-29 | vs HOU | 49 | L 1-2 | 24-25 | 3 | 34,402 | Chris Capuano | Andy Pettitte | Andy Pettitte | Chris Capuano | Brad Lidge | 217 | 187 | 30 |
| 2005-05-30 | @ SDN | 50 | L 1-2 | 24-26 | 3 | 36,152 | Victor Santos | Darrell May | Scott Linebrink | Jorge de la Rosa | | 218 | 189 | 29 |
| 2005-05-31 | @ SDN | 51 | L 4-8 | 24-27 | 3 | 23,124 | Wes Obermueller | Jake Peavy | Dennys Reyes | Gary Glover | | 222 | 197 | 25 |
| 2005-06-01 | @ SDN | 52 | W 5-2 | 25-27 | 3 | 27,692 | Doug Davis | Brian Lawrence | Doug Davis | Brian Lawrence | Julio Santana | 227 | 199 | 28 |
| 2005-06-02 | @ LAN | 53 | L 4-6 | 25-28 | 3 | 32,004 | Ben Sheets | Derek Thompson | Giovanni Carrara | Ben Sheets | Eric Gagne | 231 | 205 | 26 |
| 2005-06-03 | @ LAN | 54 | W 7-5 | 26-28 | 3 | 41,528 | Chris Capuano | Jeff Weaver | Chris Capuano | Jeff Weaver | Derrick Turnbow | 238 | 210 | 28 |
| 2005-06-04 | @ LAN | 55 | L 1-2 | 26-29 | 3 | 46,287 | Victor Santos | D.J. Houlton | D.J. Houlton | Victor Santos | Eric Gagne | 239 | 212 | 27 |
| 2005-06-05 | @ LAN | 56 | L 6-10 | 26-30 | 4 | 40,876 | Wes Obermueller | Brad Penny | Brad Penny | Wes Obermueller | | 245 | 222 | 23 |
| 2005-06-06 | vs NYA | 57 | W 4-3 | 27-30 | 3 | 34,627 | Doug Davis | Randy Johnson | Doug Davis | Randy Johnson | Derrick Turnbow | 249 | 225 | 24 |
| 2005-06-07 | vs NYA | 58 | W 2-1 | 28-30 | 3 | 35,611 | Ben Sheets | Carl Pavano | Ben Sheets | Carl Pavano | Derrick Turnbow | 251 | 226 | 25 |
| 2005-06-08 | vs NYA | 59 | L 3-12 | 28-31 | 4 | 37,586 | Chris Capuano | Mike Mussina | Mike Mussina | Chris Capuano | | 254 | 238 | 16 |
| 2005-06-10 | @ PHI | 60 | L 2-5 | 28-32 | 4 | 27,225 | Victor Santos | Brett Myers | Ryan Madson | Matt Wise | | 256 | 243 | 13 |
| 2005-06-11 | @ PHI | 61 | L 5-7 | 28-33 | 4 | 33,455 | Doug Davis | Randy Wolf | Rheal Cormier | Ricky Bottalico | Ugueth Urbina | 261 | 250 | 11 |
| 2005-06-12 | @ PHI | 62 | L 2-6 | 28-34 | 4 | 40,385 | Ben Sheets | Cory Lidle | Cory Lidle | Ben Sheets | | 263 | 256 | 7 |
| 2005-06-13 | @ TBA | 63 | L 3-5 | 28-35 | 4 | 8,878 | Chris Capuano | Doug Waechter | Doug Waechter | Chris Capuano | Danys Baez | 266 | 261 | 5 |
| 2005-06-14 | @ TBA | 64 | W 4-0 | 29-35 | 4 | 8,897 | Tomo Ohka | Casey Fossum | Tomo Ohka | Casey Fossum | | 270 | 261 | 9 |
| 2005-06-15 | @ TBA | 65 | L 3-5 | 29-36 | 4 | 8,801 | Victor Santos | Hideo Nomo | Hideo Nomo | Victor Santos | Danys Baez | 273 | 266 | 7 |
| 2005-06-17 | @ TOR | 66 | L 5-9 | 29-37 | 4 | 17,615 | Doug Davis | Gustavo Chacin | Pete Walker | Doug Davis | | 278 | 275 | 3 |
| 2005-06-18 | @ TOR | 67 | W 5-2 | 30-37 | 4 | 25,264 | Ben Sheets | Roy Halladay | Ben Sheets | Roy Halladay | Tommy Phelps | 283 | 277 | 6 |
| 2005-06-19 | @ TOR | 68 | W 5-2 | 31-37 | 4 | 30,480 | Chris Capuano | Josh Towers | Chris Capuano | Josh Towers | Derrick Turnbow | 288 | 279 | 9 |
| 2005-06-20 | vs CHN | 69 | L 4-5 | 31-38 | 4 | 40,126 | Tomo Ohka | Greg Maddux | Greg Maddux | Tomo Ohka | Ryan Dempster | 292 | 284 | 8 |
| 2005-06-21 | vs CHN | 70 | L 2-4 | 31-39 | 4 | 40,300 | Victor Santos | Jerome Williams | Jerome Williams | Victor Santos | Ryan Dempster | 294 | 288 | 6 |
| 2005-06-22 | vs CHN | 71 | W 9-4 | 32-39 | 4 | 41,453 | Doug Davis | Carlos Zambrano | Doug Davis | Carlos Zambrano | | 303 | 292 | 11 |
| 2005-06-23 | vs CHN | 72 | W 8-7 | 33-39 | 4 | 42,288 | Ben Sheets | Glendon Rusch | Ricky Bottalico | Mike Remlinger | Derrick Turnbow | 311 | 299 | 12 |
| 2005-06-24 | vs MIN | 73 | W 3-1 | 34-39 | 3 | 36,023 | Chris Capuano | Brad Radke | Chris Capuano | Brad Radke | Derrick Turnbow | 314 | 300 | 14 |
| 2005-06-25 | vs MIN | 74 | W 7-6 | 35-39 | 3 | 44,685 | Tomo Ohka | Johan Santana | Matt Wise | Johan Santana | Derrick Turnbow | 321 | 306 | 15 |
| 2005-06-26 | vs MIN | 75 | L 2-5 | 35-40 | 3 | 34,324 | Victor Santos | Kyle Lohse | Kyle Lohse | Victor Santos | | 323 | 311 | 12 |
| 2005-06-28 | @ CHN | 76 | L 0-2 | 35-41 | 3 | 39,574 | Doug Davis | Carlos Zambrano | Carlos Zambrano | Doug Davis | Ryan Dempster | 323 | 313 | 10 |
| 2005-06-29 | @ CHN | 77 | L 2-3 | 35-42 | 4 | 38,846 | Ben Sheets | Kerry Wood | Roberto Novoa | Julio Santana | | 325 | 316 | 9 |
| 2005-06-30 | @ CHN | 78 | W 10-6 | 36-42 | 3 | 38,631 | Chris Capuano | Greg Maddux | Chris Capuano | Greg Maddux | | 335 | 322 | 13 |
| 2005-07-01 | vs PIT | 79 | W 8-4 | 37-42 | 3 | 21,804 | Tomo Ohka | Mark Redman | Matt Wise | Mark Redman | | 343 | 326 | 17 |
| 2005-07-02 | vs PIT | 80 | W 5-3 | 38-42 | 3 | 29,052 | Victor Santos | Zach Duke | Ricky Bottalico | Salomon Torres | Derrick Turnbow | 348 | 329 | 19 |
| 2005-07-03 | vs PIT | 81 | L 10-11 | 38-43 | 4 | 28,323 | Doug Davis | Josh Fogg | Brian Meadows | Tommy Phelps | Jose Mesa | 358 | 340 | 18 |
| 2005-07-04 | @ FLO | 82 | W 3-2 | 39-43 | 4 | 24,207 | Ben Sheets | Scott Olsen | Ben Sheets | Todd Jones | Derrick Turnbow | 361 | 342 | 19 |
| 2005-07-05 | @ FLO | 83 | W 6-4 | 40-43 | 4 | 16,441 | Chris Capuano | Josh Beckett | Chris Capuano | Josh Beckett | Derrick Turnbow | 367 | 346 | 21 |
| 2005-07-06 | @ FLO | 84 | L 4-5 | 40-44 | 4 | 17,079 | Tomo Ohka | A.J. Burnett | Valerio de los Santos | Wes Obermueller | | 371 | 351 | 20 |
| 2005-07-07 | @ FLO | 85 | L 3-11 | 40-45 | 4 | 33,897 | Victor Santos | Brian Moehler | Brian Moehler | Victor Santos | | 374 | 362 | 12 |
| 2005-07-08 | @ ATL | 86 | L 1-2 | 40-46 | 4 | 29,402 | Doug Davis | Jorge Sosa | Danny Kolb | Julio Santana | | 375 | 364 | 11 |
| 2005-07-09 | @ ATL | 87 | W 9-6 | 41-46 | 4 | 40,514 | Ben Sheets | Kyle Davies | Ben Sheets | Kyle Davies | | 384 | 370 | 14 |
| 2005-07-10 | @ ATL | 88 | W 8-4 | 42-46 | 4 | 24,916 | Chris Capuano | Roman Colon | Chris Capuano | Roman Colon | | 392 | 374 | 18 |
| 2005-07-14 | vs WAS | 89 | W 4-2 | 43-46 | 4 | 30,611 | Doug Davis | John Patterson | Matt Wise | Gary Majewski | Derrick Turnbow | 396 | 376 | 20 |
| 2005-07-15 | vs WAS | 90 | W 4-3 | 44-46 | 4 | 40,690 | Ben Sheets | Livan Hernandez | Julio Santana | Luis Ayala | | 400 | 379 | 21 |
| 2005-07-16 | vs WAS | 91 | L 3-5 | 44-47 | 4 | 45,079 | Chris Capuano | Esteban Loaiza | Esteban Loaiza | Ricky Bottalico | Chad Cordero | 403 | 384 | 19 |
| 2005-07-17 | vs WAS | 92 | W 5-3 | 45-47 | 3 | 23,543 | Tomo Ohka | Ryan Drese | Tomo Ohka | Ryan Drese | Derrick Turnbow | 408 | 387 | 21 |
| 2005-07-18 | @ SLN | 93 | L 4-11 | 45-48 | 4 | 41,827 | Victor Santos | Matt Morris | Matt Morris | Victor Santos | | 412 | 398 | 14 |
| 2005-07-19 | @ SLN | 94 | W 5-4 | 46-48 | 4 | 44,270 | Doug Davis | Jeff Suppan | Matt Wise | Julian Tavarez | Derrick Turnbow | 417 | 402 | 15 |
| 2005-07-20 | @ SLN | 95 | L 2-4 | 46-49 | 4 | 40,904 | Ben Sheets | Mark Mulder | Mark Mulder | Ben Sheets | Jason Isringhausen | 419 | 406 | 13 |
| 2005-07-21 | @ SLN | 96 | W 12-7 | 47-49 | 4 | 44,002 | Chris Capuano | Jason Marquis | Chris Capuano | Jason Marquis | | 431 | 413 | 18 |
| 2005-07-22 | @ CIN | 97 | L 6-11 | 47-50 | 4 | 21,370 | Tomo Ohka | Ramon Ortiz | Ramon Ortiz | Tomo Ohka | | 437 | 424 | 13 |
| 2005-07-23 | @ CIN | 98 | W 11-7 | 48-50 | 4 | 36,320 | Victor Santos | Brandon Claussen | Victor Santos | Brandon Claussen | | 448 | 431 | 17 |
| 2005-07-24 | @ CIN | 99 | L 2-3 | 48-51 | 4 | 18,856 | Doug Davis | Luke Hudson | David Weathers | Julio Santana | | 450 | 434 | 16 |
| 2005-07-25 | vs ARI | 100 | W 4-2 | 49-51 | 4 | 20,062 | Ben Sheets | Mike Gosling | Ben Sheets | Tim Worrell | Derrick Turnbow | 454 | 436 | 18 |
| 2005-07-26 | vs ARI | 101 | W 7-2 | 50-51 | 4 | 31,128 | Chris Capuano | Brandon Webb | Dana Eveland | Brandon Webb | | 461 | 438 | 23 |
| 2005-07-27 | vs ARI | 102 | L 0-3 | 50-52 | 4 | 28,971 | Tomo Ohka | Claudio Vargas | Claudio Vargas | Tomo Ohka | Brian Bruney | 461 | 441 | 20 |
| 2005-07-28 | vs SFN | 103 | L 0-3 | 50-53 | 4 | 22,252 | Victor Santos | Brad Hennessey | Brad Hennessey | Victor Santos | Tyler Walker | 461 | 444 | 17 |
| 2005-07-29 | vs SFN | 104 | L 6-7 | 50-54 | 4 | 28,652 | Doug Davis | Kirk Rueter | Jeff Fassero | Matt Wise | Tyler Walker | 467 | 451 | 16 |
| 2005-07-30 | vs SFN | 105 | W 7-1 | 51-54 | 4 | 38,462 | Ben Sheets | Jason Schmidt | Ben Sheets | Jason Schmidt | | 474 | 452 | 22 |
| 2005-07-31 | vs SFN | 106 | W 5-1 | 52-54 | 4 | 36,148 | Chris Capuano | Noah Lowry | Chris Capuano | Noah Lowry | | 479 | 453 | 26 |
| 2005-08-02 | @ NYN | 107 | L 8-9 | 52-55 | 4 | 32,453 | Tomo Ohka | Victor Zambrano | Braden Looper | Julio Santana | | 487 | 462 | 25 |
| 2005-08-03 | @ NYN | 108 | W 6-4 | 53-55 | 4 | 40,659 | Victor Santos | Pedro Martinez | Rick Helling | Braden Looper | Derrick Turnbow | 493 | 466 | 27 |
| 2005-08-04 | @ NYN | 109 | W 12-9 | 54-55 | 4 | 30,359 | Doug Davis | Kris Benson | Julio Santana | Roberto Hernandez | Derrick Turnbow | 505 | 475 | 30 |
| 2005-08-05 | @ PHI | 110 | W 3-1 | 55-55 | 3 | 31,759 | Ben Sheets | Cory Lidle | Ben Sheets | Geoff Geary | Matt Wise | 508 | 476 | 32 |
| 2005-08-06 | @ PHI | 111 | L 2-8 | 55-56 | 3 | 35,800 | Chris Capuano | Jon Lieber | Jon Lieber | Chris Capuano | | 510 | 484 | 26 |
| 2005-08-07 | @ PHI | 112 | W 2-0 | 56-56 | 3 | 35,017 | Tomo Ohka | Vicente Padilla | Tomo Ohka | Vicente Padilla | Derrick Turnbow | 512 | 484 | 28 |
| 2005-08-08 | vs SLN | 113 | L 4-8 | 56-57 | 3 | 30,260 | Victor Santos | Matt Morris | Randy Flores | Matt Wise | | 516 | 492 | 24 |
| 2005-08-09 | vs SLN | 114 | L 2-5 | 56-58 | 3 | 28,556 | Doug Davis | Anthony Reyes | Anthony Reyes | Doug Davis | Jason Isringhausen | 518 | 497 | 21 |
| 2005-08-10 | vs SLN | 115 | L 0-3 | 56-59 | 3 | 37,650 | Ben Sheets | Jeff Suppan | Jeff Suppan | Ben Sheets | Jason Isringhausen | 518 | 500 | 18 |
| 2005-08-12 | vs CIN | 116 | L 3-5 | 56-60 | 4 | 24,103 | Chris Capuano | Luke Hudson | Luke Hudson | Chris Capuano | David Weathers | 521 | 505 | 16 |
| 2005-08-13 | vs CIN | 117 | L 1-4 | 56-61 | 4 | 41,282 | Tomo Ohka | Ramon Ortiz | Ramon Ortiz | Tomo Ohka | David Weathers | 522 | 509 | 13 |
| 2005-08-14 | vs CIN | 118 | W 8-3 | 57-61 | 4 | 29,262 | Doug Davis | Brandon Claussen | Kane Davis | Matt Belisle | | 530 | 512 | 18 |
| 2005-08-15 | @ COL | 119 | L 2-11 | 57-62 | 4 | 18,596 | Ben Sheets | Aaron Cook | Aaron Cook | Ben Sheets | | 532 | 523 | 9 |
| 2005-08-16 | @ COL | 120 | W 6-4 | 58-62 | 4 | 18,582 | Victor Santos | Jeff Francis | Victor Santos | Jeff Francis | Derrick Turnbow | 538 | 527 | 11 |
| 2005-08-17 | @ COL | 121 | W 2-0 | 59-62 | 4 | 19,288 | Chris Capuano | Jamey Wright | Chris Capuano | Jamey Wright | Derrick Turnbow | 540 | 527 | 13 |
| 2005-08-18 | @ HOU | 122 | W 5-2 | 60-62 | 3 | 29,844 | Tomo Ohka | Roger Clemens | Tomo Ohka | Roger Clemens | Derrick Turnbow | 545 | 529 | 16 |
| 2005-08-19 | @ HOU | 123 | L 3-5 | 60-63 | 4 | 31,651 | Doug Davis | Ezequiel Astacio | Russ Springer | Doug Davis | Brad Lidge | 548 | 534 | 14 |
| 2005-08-20 | @ HOU | 124 | W 3-2 | 61-63 | 3 | 41,101 | Ben Sheets | Wandy Rodriguez | Ben Sheets | Chad Harville | | 551 | 536 | 15 |
| 2005-08-21 | @ HOU | 125 | L 3-8 | 61-64 | 3 | 35,712 | Victor Santos | Andy Pettitte | Andy Pettitte | Victor Santos | | 554 | 544 | 10 |
| 2005-08-23 | vs FLO | 126 | W 11-2 | 62-64 | 3 | 20,318 | Chris Capuano | Josh Beckett | Chris Capuano | Josh Beckett | | 565 | 546 | 19 |
| 2005-08-24 | vs FLO | 127 | W 6-4 | 63-64 | 3 | 33,323 | Tomo Ohka | A.J. Burnett | Tomo Ohka | A.J. Burnett | Derrick Turnbow | 571 | 550 | 21 |
| 2005-08-25 | vs FLO | 128 | L 1-3 | 63-65 | 3 | 22,843 | Doug Davis | Ismael Valdez | Antonio Alfonseca | Jose Capellan | Todd Jones | 572 | 553 | 19 |
| 2005-08-26 | vs ATL | 129 | W 3-1 | 64-65 | 3 | 30,670 | Ben Sheets | Horacio Ramirez | Ben Sheets | Horacio Ramirez | Derrick Turnbow | 575 | 554 | 21 |
| 2005-08-27 | vs ATL | 130 | L 4-8 | 64-66 | 3 | 42,464 | Rick Helling | John Smoltz | John Smoltz | Victor Santos | | 579 | 562 | 17 |
| 2005-08-28 | vs ATL | 131 | L 2-5 | 64-67 | 3 | 35,060 | Chris Capuano | Tim Hudson | Tim Hudson | Chris Capuano | | 581 | 567 | 14 |
| 2005-08-30 | vs PIT | 132 | L 0-6 | 64-68 | 3 | 28,337 | Doug Davis | Paul Maholm | Paul Maholm | Doug Davis | | 581 | 573 | 8 |
| 2005-08-31 | vs PIT | 133 | W 6-5 | 65-68 | 3 | 15,062 | Tomo Ohka | Mark Redman | Derrick Turnbow | Jose Mesa | | 587 | 578 | 9 |
| 2005-09-01 | vs SDN | 134 | L 5-6 | 65-69 | 3 | 24,785 | Rick Helling | Adam Eaton | Rudy Seanez | Kane Davis | Trevor Hoffman | 592 | 584 | 8 |
| 2005-09-02 | vs SDN | 135 | W 12-2 | 66-69 | 3 | 18,231 | Chris Capuano | Brian Lawrence | Chris Capuano | Brian Lawrence | | 604 | 586 | 18 |
| 2005-09-03 | vs SDN | 136 | L 1-6 | 66-70 | 3 | 32,022 | Wes Obermueller | Woody Williams | Woody Williams | Wes Obermueller | | 605 | 592 | 13 |
| 2005-09-04 | vs SDN | 137 | W 3-2 | 67-70 | 3 | 20,042 | Doug Davis | Jake Peavy | Derrick Turnbow | Akinori Otsuka | | 608 | 594 | 14 |
| 2005-09-05 | @ CIN | 138 | W 6-1 | 68-70 | 3 | 16,144 | Tomo Ohka | Brandon Claussen | Tomo Ohka | Matt Belisle | Dana Eveland | 614 | 595 | 19 |
| 2005-09-06 | @ CIN | 139 | L 1-2 | 68-71 | 3 | 13,351 | Rick Helling | Aaron Harang | Kent Mercker | Jorge de la Rosa | | 615 | 597 | 18 |
| 2005-09-07 | @ CIN | 140 | W 14-5 | 69-71 | 3 | 15,886 | Chris Capuano | Eric Milton | Chris Capuano | Eric Milton | | 629 | 602 | 27 |
| 2005-09-09 | vs HOU | 141 | W 7-4 | 70-71 | 3 | 18,130 | Doug Davis | Roger Clemens | Doug Davis | Roger Clemens | Derrick Turnbow | 636 | 606 | 30 |
| 2005-09-10 | vs HOU | 142 | L 5-7 | 70-72 | 4 | 24,437 | Tomo Ohka | Andy Pettitte | Andy Pettitte | Tomo Ohka | Brad Lidge | 641 | 613 | 28 |
| 2005-09-11 | vs HOU | 143 | W 4-2 | 71-72 | 4 | 17,392 | Rick Helling | Roy Oswalt | Rick Helling | Roy Oswalt | Derrick Turnbow | 645 | 615 | 30 |
| 2005-09-13 | @ ARI | 144 | W 3-1 | 72-72 | 3 | 23,708 | Chris Capuano | Javier Vazquez | Chris Capuano | Javier Vazquez | Derrick Turnbow | 648 | 616 | 32 |
| 2005-09-14 | @ ARI | 145 | L 1-2 | 72-73 | 3 | 23,793 | Doug Davis | Brandon Webb | Brandon Medders | Justin Lehr | | 649 | 618 | 31 |
| 2005-09-15 | @ ARI | 146 | W 14-2 | 73-73 | 3 | 20,741 | Tomo Ohka | Shawn Estes | Tomo Ohka | Shawn Estes | | 663 | 620 | 43 |
| 2005-09-16 | @ HOU | 147 | L 1-2 | 73-74 | 3 | 33,767 | Rick Helling | Roy Oswalt | Brad Lidge | Dana Eveland | | 664 | 622 | 42 |
| 2005-09-17 | @ HOU | 148 | L 0-7 | 73-75 | 3 | 37,756 | Wes Obermueller | Brandon Backe | Brandon Backe | Wes Obermueller | | 664 | 629 | 35 |
| 2005-09-18 | @ HOU | 149 | L 1-6 | 73-76 | 4 | 35,052 | Chris Capuano | Wandy Rodriguez | Wandy Rodriguez | Chris Capuano | | 665 | 635 | 30 |
| 2005-09-20 | vs CHN | 150 | W 5-3 | 74-76 | 3 | 30,136 | Doug Davis | Jerome Williams | Doug Davis | Jerome Williams | Derrick Turnbow | 670 | 638 | 32 |
| 2005-09-21 | vs CHN | 151 | W 7-6 | 75-76 | 3 | 30,049 | Tomo Ohka | Mark Prior | Derrick Turnbow | Jermaine Van Buren | | 677 | 644 | 33 |
| 2005-09-22 | vs CHN | 152 | L 0-3 | 75-77 | 3 | 31,137 | Rick Helling | Greg Maddux | Greg Maddux | Rick Helling | Ryan Dempster | 677 | 647 | 30 |
| 2005-09-23 | vs SLN | 153 | W 9-6 | 76-77 | 3 | 22,472 | Chris Capuano | Chris Carpenter | Chris Capuano | Chris Carpenter | Derrick Turnbow | 686 | 653 | 33 |
| 2005-09-24 | vs SLN | 154 | W 8-7 | 77-77 | 3 | 33,506 | Gary Glover | Mark Mulder | Gary Glover | Mark Mulder | Derrick Turnbow | 694 | 660 | 34 |
| 2005-09-25 | vs SLN | 155 | L 0-2 | 77-78 | 3 | 20,150 | Doug Davis | Jeff Suppan | Jeff Suppan | Doug Davis | Jason Isringhausen | 694 | 662 | 32 |
| 2005-09-26 | vs CIN | 156 | W 12-9 | 78-78 | 3 | 14,412 | Tomo Ohka | Ramon Ortiz | Jose Capellan | Todd Coffey | Derrick Turnbow | 706 | 671 | 35 |
| 2005-09-27 | vs CIN | 157 | W 6-2 | 79-78 | 3 | 28,031 | Rick Helling | Brandon Claussen | Rick Helling | Brandon Claussen | Derrick Turnbow | 712 | 673 | 39 |
| 2005-09-28 | vs CIN | 158 | L 4-11 | 79-79 | 3 | 21,181 | Chris Capuano | Aaron Harang | Aaron Harang | Chris Capuano | | 716 | 684 | 32 |
| 2005-09-29 | vs CIN | 159 | W 2-0 | 80-79 | 3 | 13,173 | Gary Glover | Eric Milton | Gary Glover | Eric Milton | Derrick Turnbow | 718 | 684 | 34 |
| 2005-09-30 | @ PIT | 160 | W 6-5 | 81-79 | 3 | 20,922 | Doug Davis | Oliver Perez | Justin Lehr | Ryan Vogelsong | Derrick Turnbow | 724 | 689 | 35 |
| 2005-10-01 | @ PIT | 161 | L 1-5 | 81-80 | 3 | 17,261 | Tomo Ohka | Kip Wells | Kip Wells | Tomo Ohka | | 725 | 694 | 31 |
| 2005-10-02 | @ PIT | 162 | L 1-3 | 81-81 | 3 | 23,008 | Chris Capuano | Zach Duke | Zach Duke | Chris Capuano | Salomon Torres | 726 | 697 | 29 |