| 2005-04-05 | vs SLN | 1 | L 3-7 | - | | 43,567 | Roy Oswalt | Chris Carpenter | Chris Carpenter | Roy Oswalt | Jason Isringhausen | 3 | 7 | -4 |
| 2005-04-06 | vs SLN | 2 | W 4-1 | - | | 28,496 | Andy Pettitte | Jason Marquis | Chad Qualls | Julian Tavarez | Brad Lidge | 7 | 8 | -1 |
| 2005-04-08 | vs CIN | 3 | W 3-2 | - | | 36,382 | Roger Clemens | Ramon Ortiz | Roger Clemens | Matt Belisle | Brad Lidge | 10 | 10 | 0 |
| 2005-04-09 | vs CIN | 4 | W 4-3 | - | | 34,502 | Brandon Backe | Paul Wilson | Brad Lidge | Ryan Wagner | | 14 | 13 | 1 |
| 2005-04-10 | vs CIN | 5 | W 5-2 | - | | 31,832 | Roy Oswalt | Eric Milton | Roy Oswalt | Eric Milton | Brad Lidge | 19 | 15 | 4 |
| 2005-04-11 | @ NYN | 6 | L 4-8 | - | | 53,663 | Andy Pettitte | Tom Glavine | Roberto Hernandez | Russ Springer | | 23 | 23 | 0 |
| 2005-04-13 | @ NYN | 7 | L 0-1 | - | | 22,431 | Roger Clemens | Kazuhisa Ishii | Mike DeJean | Dan Wheeler | | 23 | 24 | -1 |
| 2005-04-14 | @ NYN | 8 | L 3-4 | - | | 17,214 | Brandon Backe | Victor Zambrano | Mike Matthews | John Franco | Braden Looper | 26 | 28 | -2 |
| 2005-04-15 | @ CIN | 9 | W 11-2 | - | | 31,740 | Roy Oswalt | Paul Wilson | Roy Oswalt | Paul Wilson | | 37 | 30 | 7 |
| 2005-04-16 | @ CIN | 10 | L 2-3 | - | | 26,926 | Andy Pettitte | Eric Milton | Eric Milton | Andy Pettitte | Danny Graves | 39 | 33 | 6 |
| 2005-04-17 | @ CIN | 11 | L 5-6 | - | | 25,762 | Brandon Duckworth | Aaron Harang | Ryan Wagner | Chad Qualls | Danny Graves | 44 | 39 | 5 |
| 2005-04-18 | vs ATL | 12 | L 0-1 | - | | 31,672 | Roger Clemens | Tim Hudson | Jorge Sosa | Dan Wheeler | Danny Kolb | 44 | 40 | 4 |
| 2005-04-19 | vs ATL | 13 | W 5-3 | - | | 32,146 | Brandon Backe | John Thomson | Brandon Backe | John Thomson | Brad Lidge | 49 | 43 | 6 |
| 2005-04-20 | vs MIL | 14 | W 6-1 | - | | 26,119 | Roy Oswalt | Ben Sheets | Roy Oswalt | Ben Sheets | | 55 | 44 | 11 |
| 2005-04-21 | vs MIL | 15 | W 8-7 | - | | 32,173 | Andy Pettitte | Doug Davis | Andy Pettitte | Doug Davis | Brad Lidge | 63 | 51 | 12 |
| 2005-04-22 | @ SLN | 16 | L 7-8 | - | | 44,805 | Brandon Duckworth | Jason Marquis | Jason Marquis | Brandon Duckworth | Jason Isringhausen | 70 | 59 | 11 |
| 2005-04-23 | @ SLN | 17 | L 0-1 | - | | 40,058 | Roger Clemens | Mark Mulder | Mark Mulder | Chad Qualls | | 70 | 60 | 10 |
| 2005-04-24 | @ SLN | 18 | L 5-8 | - | | 39,020 | Brandon Backe | Matt Morris | Matt Morris | Brandon Backe | Jason Isringhausen | 75 | 68 | 7 |
| 2005-04-25 | @ PIT | 19 | L 0-2 | - | | 8,413 | Roy Oswalt | Oliver Perez | Oliver Perez | Roy Oswalt | Jose Mesa | 75 | 70 | 5 |
| 2005-04-27 | @ PIT | 20 | L 0-2 | - | | 13,426 | Andy Pettitte | Kip Wells | Kip Wells | Andy Pettitte | Jose Mesa | 75 | 72 | 3 |
| 2005-04-29 | vs CHN | 21 | L 2-3 | - | | 41,232 | Roger Clemens | Greg Maddux | Greg Maddux | Roger Clemens | LaTroy Hawkins | 77 | 75 | 2 |
| 2005-04-30 | vs CHN | 22 | W 7-5 | - | | 41,615 | Brandon Backe | Kerry Wood | Brandon Backe | Cliff Bartosh | | 84 | 80 | 4 |
| 2005-05-01 | vs CHN | 23 | W 9-3 | - | | 38,014 | Roy Oswalt | Mark Prior | Roy Oswalt | Mark Prior | | 93 | 83 | 10 |
| 2005-05-02 | vs PIT | 24 | W 11-4 | - | | 23,882 | Andy Pettitte | Josh Fogg | Andy Pettitte | Josh Fogg | | 104 | 87 | 17 |
| 2005-05-03 | vs PIT | 25 | L 4-7 | - | | 27,809 | Ezequiel Astacio | Kip Wells | Rick White | Chad Qualls | Jose Mesa | 108 | 94 | 14 |
| 2005-05-04 | vs PIT | 26 | L 4-6 | - | | 29,299 | Roger Clemens | Mark Redman | Salomon Torres | Brad Lidge | Jose Mesa | 112 | 100 | 12 |
| 2005-05-05 | @ ATL | 27 | L 3-9 | - | | 20,553 | Brandon Backe | John Thomson | John Thomson | Brandon Backe | | 115 | 109 | 6 |
| 2005-05-06 | @ ATL | 28 | L 4-9 | - | | 26,987 | Roy Oswalt | John Smoltz | John Smoltz | Roy Oswalt | | 119 | 118 | 1 |
| 2005-05-07 | @ ATL | 29 | L 1-4 | - | | 36,452 | Andy Pettitte | Horacio Ramirez | Horacio Ramirez | Andy Pettitte | Danny Kolb | 120 | 122 | -2 |
| 2005-05-08 | @ ATL | 30 | L 0-16 | - | | 32,498 | Ezequiel Astacio | Mike Hampton | Mike Hampton | Ezequiel Astacio | | 120 | 138 | -18 |
| 2005-05-09 | @ FLO | 31 | W 2-1 | - | | 20,539 | Roger Clemens | A.J. Burnett | Roger Clemens | A.J. Burnett | Brad Lidge | 122 | 139 | -17 |
| 2005-05-10 | @ FLO | 32 | L 2-6 | - | | 11,687 | Brandon Backe | Brian Moehler | Jim Mecir | Russ Springer | | 124 | 145 | -21 |
| 2005-05-11 | @ FLO | 33 | L 1-2 | - | | 21,789 | Roy Oswalt | Dontrelle Willis | Dontrelle Willis | Roy Oswalt | Todd Jones | 125 | 147 | -22 |
| 2005-05-12 | vs SFN | 34 | L 3-6 | - | | 29,126 | Andy Pettitte | Brad Hennessey | Brad Hennessey | Andy Pettitte | Tyler Walker | 128 | 153 | -25 |
| 2005-05-13 | vs SFN | 35 | L 2-4 | - | | 31,365 | Ezequiel Astacio | Kirk Rueter | Kirk Rueter | Ezequiel Astacio | Tyler Walker | 130 | 157 | -27 |
| 2005-05-14 | vs SFN | 36 | W 4-1 | - | | 41,323 | Roger Clemens | Brett Tomko | Roger Clemens | Brett Tomko | Brad Lidge | 134 | 158 | -24 |
| 2005-05-15 | vs SFN | 37 | W 9-0 | - | | 33,633 | Brandon Backe | Jeff Fassero | Brandon Backe | Jeff Fassero | | 143 | 158 | -15 |
| 2005-05-17 | vs ARI | 38 | W 3-0 | - | | 27,156 | Roy Oswalt | Javier Vazquez | Roy Oswalt | Javier Vazquez | Brad Lidge | 146 | 158 | -12 |
| 2005-05-18 | vs ARI | 39 | L 6-7 | - | | 27,790 | Andy Pettitte | Russ Ortiz | Russ Ortiz | Andy Pettitte | Brian Bruney | 152 | 165 | -13 |
| 2005-05-19 | vs ARI | 40 | L 1-6 | - | | 32,132 | Roger Clemens | Brad Halsey | Brad Halsey | Roger Clemens | Jose Valverde | 153 | 171 | -18 |
| 2005-05-20 | @ TEX | 41 | L 3-7 | - | | 38,109 | Brandon Backe | Kenny Rogers | Kenny Rogers | Brandon Backe | | 156 | 178 | -22 |
| 2005-05-21 | @ TEX | 42 | L 3-18 | - | | 35,781 | Ezequiel Astacio | Chris Young | Chris Young | Ezequiel Astacio | | 159 | 196 | -37 |
| 2005-05-22 | @ TEX | 43 | L 0-2 | - | | 40,583 | Roy Oswalt | Chan Ho Park | Chan Ho Park | Roy Oswalt | Francisco Cordero | 159 | 198 | -39 |
| 2005-05-23 | @ CHN | 44 | L 1-4 | - | | 38,232 | Wandy Rodriguez | Glendon Rusch | Glendon Rusch | Wandy Rodriguez | Ryan Dempster | 160 | 202 | -42 |
| 2005-05-24 | @ CHN | 45 | L 2-4 | - | | 38,805 | Roger Clemens | Sergio Mitre | Michael Wuertz | Brad Lidge | Ryan Dempster | 162 | 206 | -44 |
| 2005-05-25 | @ CHN | 46 | W 5-1 | - | | 38,118 | Brandon Backe | Greg Maddux | Brandon Backe | Greg Maddux | | 167 | 207 | -40 |
| 2005-05-27 | @ MIL | 47 | L 0-3 | - | | 22,173 | Roy Oswalt | Doug Davis | Doug Davis | Roy Oswalt | Derrick Turnbow | 167 | 210 | -43 |
| 2005-05-28 | @ MIL | 48 | W 9-6 | - | | 37,845 | Wandy Rodriguez | Ben Sheets | Wandy Rodriguez | Ben Sheets | Brad Lidge | 176 | 216 | -40 |
| 2005-05-29 | @ MIL | 49 | W 2-1 | - | | 34,402 | Andy Pettitte | Chris Capuano | Andy Pettitte | Chris Capuano | Brad Lidge | 178 | 217 | -39 |
| 2005-05-30 | vs CIN | 50 | L 0-9 | - | | 42,097 | Roger Clemens | Aaron Harang | Aaron Harang | Roger Clemens | | 178 | 226 | -48 |
| 2005-05-31 | vs CIN | 51 | W 4-3 | - | | 28,535 | Brandon Backe | Matt Belisle | Brandon Backe | Matt Belisle | Brad Lidge | 182 | 229 | -47 |
| 2005-06-01 | vs CIN | 52 | W 4-1 | - | | 31,571 | Roy Oswalt | Ramon Ortiz | Roy Oswalt | Ramon Ortiz | Brad Lidge | 186 | 230 | -44 |
| 2005-06-03 | vs SLN | 53 | L 0-2 | - | | 34,092 | Andy Pettitte | Chris Carpenter | Chris Carpenter | Andy Pettitte | Julian Tavarez | 186 | 232 | -46 |
| 2005-06-04 | vs SLN | 54 | L 9-11 | - | | 39,288 | Wandy Rodriguez | Jason Marquis | Jason Marquis | Wandy Rodriguez | Jason Isringhausen | 195 | 243 | -48 |
| 2005-06-05 | vs SLN | 55 | W 6-4 | - | | 34,009 | Roger Clemens | Mark Mulder | Roger Clemens | Mark Mulder | Brad Lidge | 201 | 247 | -46 |
| 2005-06-07 | @ NYN | 56 | L 1-3 | - | | 39,953 | Roy Oswalt | Pedro Martinez | Pedro Martinez | Roy Oswalt | | 202 | 250 | -48 |
| 2005-06-08 | @ NYN | 57 | W 4-1 | - | | 23,635 | Brandon Backe | Victor Zambrano | Brandon Backe | Victor Zambrano | Brad Lidge | 206 | 251 | -45 |
| 2005-06-09 | @ NYN | 58 | W 6-3 | - | | 30,737 | Andy Pettitte | Tom Glavine | Russ Springer | Heath Bell | Brad Lidge | 212 | 254 | -42 |
| 2005-06-10 | vs TOR | 59 | W 4-2 | - | | 28,607 | Wandy Rodriguez | Ted Lilly | Wandy Rodriguez | Ted Lilly | Brad Lidge | 216 | 256 | -40 |
| 2005-06-11 | vs TOR | 60 | W 6-3 | - | | 34,925 | Roger Clemens | Gustavo Chacin | Brad Lidge | Scott Schoeneweis | | 222 | 259 | -37 |
| 2005-06-12 | vs TOR | 61 | W 3-0 | - | | 30,584 | Roy Oswalt | Josh Towers | Roy Oswalt | Josh Towers | | 225 | 259 | -34 |
| 2005-06-13 | @ BAL | 62 | L 5-8 | - | | 23,297 | Brandon Backe | Hayden Penn | Hayden Penn | Brandon Backe | B.J. Ryan | 230 | 267 | -37 |
| 2005-06-14 | @ BAL | 63 | L 1-6 | - | | 24,659 | Andy Pettitte | Bruce Chen | Bruce Chen | Andy Pettitte | | 231 | 273 | -42 |
| 2005-06-15 | @ BAL | 64 | L 1-5 | - | | 31,547 | Wandy Rodriguez | Rodrigo Lopez | Rodrigo Lopez | Wandy Rodriguez | | 232 | 278 | -46 |
| 2005-06-17 | @ KCA | 65 | W 7-0 | - | | 27,385 | Roger Clemens | J.P. Howell | Roger Clemens | J.P. Howell | | 239 | 278 | -39 |
| 2005-06-18 | @ KCA | 66 | W 6-2 | - | | 26,523 | Roy Oswalt | D.J. Carrasco | Roy Oswalt | D.J. Carrasco | | 245 | 280 | -35 |
| 2005-06-19 | @ KCA | 67 | L 1-7 | - | | 20,214 | Brandon Backe | Runelvys Hernandez | Runelvys Hernandez | Brandon Backe | | 246 | 287 | -41 |
| 2005-06-20 | vs COL | 68 | W 7-0 | - | | 28,237 | Andy Pettitte | Joe Kennedy | Andy Pettitte | Joe Kennedy | | 253 | 287 | -34 |
| 2005-06-21 | vs COL | 69 | W 6-5 | - | | 28,788 | Wandy Rodriguez | Jamey Wright | Chad Qualls | Jamey Wright | Brad Lidge | 259 | 292 | -33 |
| 2005-06-22 | vs COL | 70 | W 6-2 | - | | 39,415 | Roger Clemens | Jason Jennings | Roger Clemens | Jason Jennings | | 265 | 294 | -29 |
| 2005-06-24 | vs TEX | 71 | W 5-2 | - | | 36,199 | Roy Oswalt | Ricardo Rodriguez | Roy Oswalt | Ricardo Rodriguez | Brad Lidge | 270 | 296 | -26 |
| 2005-06-25 | vs TEX | 72 | L 5-6 | - | | 41,868 | Brandon Backe | Chris Young | Chris Young | Brandon Backe | Francisco Cordero | 275 | 302 | -27 |
| 2005-06-26 | vs TEX | 73 | W 3-2 | - | | 35,331 | Andy Pettitte | Chan Ho Park | Chad Qualls | Juan Dominguez | | 278 | 304 | -26 |
| 2005-06-27 | @ COL | 74 | W 11-5 | - | | 21,877 | Wandy Rodriguez | Jamey Wright | Wandy Rodriguez | Jamey Wright | | 289 | 309 | -20 |
| 2005-06-28 | @ COL | 75 | L 5-6 | - | | 28,726 | Roger Clemens | Jason Jennings | David Cortes | Russ Springer | Brian Fuentes | 294 | 315 | -21 |
| 2005-06-29 | @ COL | 76 | W 7-1 | - | | 23,494 | Roy Oswalt | Byung-Hyun Kim | Roy Oswalt | Byung-Hyun Kim | | 301 | 316 | -15 |
| 2005-06-30 | @ CIN | 77 | L 2-2 | - | | 19,903 | Brandon Backe | Eric Milton | | | | 303 | 318 | -15 |
| 2005-07-01 | @ CIN | 78 | W 10-7 | - | | 24,923 | Andy Pettitte | Luke Hudson | Andy Pettitte | Luke Hudson | Dan Wheeler | 313 | 325 | -12 |
| 2005-07-02 | @ CIN | 79 | W 4-3 | - | | 0 | Wandy Rodriguez | Aaron Harang | Wandy Rodriguez | Aaron Harang | Dan Wheeler | 317 | 328 | -11 |
| 2005-07-02 | @ CIN | 80 | L 6-11 | - | | 28,236 | Ezequiel Astacio | Ramon Ortiz | Ramon Ortiz | Ezequiel Astacio | | 323 | 339 | -16 |
| 2005-07-03 | @ CIN | 81 | W 9-0 | - | | 27,506 | Roger Clemens | Brandon Claussen | Roger Clemens | Brandon Claussen | | 332 | 339 | -7 |
| 2005-07-04 | vs SDN | 82 | W 4-1 | - | | 40,550 | Roy Oswalt | Brian Lawrence | Roy Oswalt | Brian Lawrence | | 336 | 340 | -4 |
| 2005-07-05 | vs SDN | 83 | W 6-2 | - | | 27,307 | Brandon Backe | Dennys Reyes | Brandon Backe | Dennys Reyes | | 342 | 342 | 0 |
| 2005-07-06 | vs SDN | 84 | W 5-4 | - | | 29,774 | Andy Pettitte | Jake Peavy | Andy Pettitte | Jake Peavy | Dan Wheeler | 347 | 346 | 1 |
| 2005-07-07 | vs SDN | 85 | L 5-7 | - | | 28,810 | Wandy Rodriguez | Woody Williams | Woody Williams | Wandy Rodriguez | Trevor Hoffman | 352 | 353 | -1 |
| 2005-07-08 | vs LAN | 86 | W 3-2 | - | | 36,176 | Roger Clemens | D.J. Houlton | Brad Lidge | Yhency Brazoban | | 355 | 355 | 0 |
| 2005-07-09 | vs LAN | 87 | W 4-2 | - | | 37,196 | Roy Oswalt | Jeff Weaver | Roy Oswalt | Jeff Weaver | Brad Lidge | 359 | 357 | 2 |
| 2005-07-10 | vs LAN | 88 | W 6-5 | - | | 39,177 | Brandon Backe | Odalis Perez | Russ Springer | Duaner Sanchez | Brad Lidge | 365 | 362 | 3 |
| 2005-07-15 | @ SLN | 89 | L 3-4 | - | | 48,420 | Andy Pettitte | Mark Mulder | Brad Thompson | Chad Harville | | 368 | 366 | 2 |
| 2005-07-16 | @ SLN | 90 | L 2-4 | - | | 48,034 | Roy Oswalt | Jason Marquis | Jason Marquis | Roy Oswalt | Jason Isringhausen | 370 | 370 | 0 |
| 2005-07-17 | @ SLN | 91 | L 0-3 | - | | 46,584 | Roger Clemens | Chris Carpenter | Chris Carpenter | Roger Clemens | | 370 | 373 | -3 |
| 2005-07-18 | @ PIT | 92 | W 11-1 | - | | 17,590 | Brandon Backe | David Williams | Brandon Backe | David Williams | | 381 | 374 | 7 |
| 2005-07-19 | @ PIT | 93 | W 9-3 | - | | 0 | Ezequiel Astacio | Ian Snell | Ezequiel Astacio | Ian Snell | | 390 | 377 | 13 |
| 2005-07-19 | @ PIT | 94 | W 6-4 | - | | 20,552 | Wandy Rodriguez | Mark Redman | Wandy Rodriguez | Mark Redman | Brad Lidge | 396 | 381 | 15 |
| 2005-07-20 | @ PIT | 95 | W 8-0 | - | | 19,769 | Andy Pettitte | Josh Fogg | Andy Pettitte | Josh Fogg | | 404 | 381 | 23 |
| 2005-07-21 | @ WAS | 96 | W 3-2 | - | | 36,840 | Roy Oswalt | Esteban Loaiza | Roy Oswalt | Esteban Loaiza | Brad Lidge | 407 | 383 | 24 |
| 2005-07-22 | @ WAS | 97 | W 14-1 | - | | 38,019 | Roger Clemens | Ryan Drese | Roger Clemens | Ryan Drese | | 421 | 384 | 37 |
| 2005-07-23 | @ WAS | 98 | L 2-4 | - | | 42,680 | Brandon Backe | Tony Armas | Tony Armas | Brandon Backe | Chad Cordero | 423 | 388 | 35 |
| 2005-07-24 | @ WAS | 99 | W 4-1 | - | | 39,203 | Wandy Rodriguez | John Patterson | Russ Springer | Hector Carrasco | Brad Lidge | 427 | 389 | 38 |
| 2005-07-25 | vs PHI | 100 | W 7-1 | - | | 36,029 | Andy Pettitte | Cory Lidle | Andy Pettitte | Cory Lidle | | 434 | 390 | 44 |
| 2005-07-26 | vs PHI | 101 | W 2-1 | - | | 33,867 | Roy Oswalt | Jon Lieber | Roy Oswalt | Ryan Madson | | 436 | 391 | 45 |
| 2005-07-27 | vs PHI | 102 | W 3-2 | - | | 38,071 | Roger Clemens | Vicente Padilla | Roger Clemens | Vicente Padilla | Brad Lidge | 439 | 393 | 46 |
| 2005-07-28 | vs NYN | 103 | W 3-2 | - | | 43,552 | Ezequiel Astacio | Pedro Martinez | Dan Wheeler | Roberto Hernandez | | 442 | 395 | 47 |
| 2005-07-29 | vs NYN | 104 | W 5-2 | - | | 42,659 | Wandy Rodriguez | Kris Benson | Wandy Rodriguez | Kris Benson | Brad Lidge | 447 | 397 | 50 |
| 2005-07-30 | vs NYN | 105 | W 2-0 | - | | 43,596 | Andy Pettitte | Tom Glavine | Andy Pettitte | Tom Glavine | Brad Lidge | 449 | 397 | 52 |
| 2005-07-31 | vs NYN | 106 | L 4-9 | - | | 43,028 | Roy Oswalt | Kazuhisa Ishii | Aaron Heilman | Dan Wheeler | | 453 | 406 | 47 |
| 2005-08-02 | @ ARI | 107 | W 3-1 | - | | 31,696 | Roger Clemens | Claudio Vargas | Roger Clemens | Claudio Vargas | Brad Lidge | 456 | 407 | 49 |
| 2005-08-03 | @ ARI | 108 | W 7-0 | - | | 22,283 | Ezequiel Astacio | Javier Vazquez | Ezequiel Astacio | Javier Vazquez | | 463 | 407 | 56 |
| 2005-08-04 | @ ARI | 109 | L 3-7 | - | | 23,217 | Wandy Rodriguez | Brad Halsey | Brad Halsey | Wandy Rodriguez | Jose Valverde | 466 | 414 | 52 |
| 2005-08-05 | @ SFN | 110 | L 0-4 | - | | 39,686 | Andy Pettitte | Jason Schmidt | Jason Schmidt | Andy Pettitte | | 466 | 418 | 48 |
| 2005-08-06 | @ SFN | 111 | L 2-5 | - | | 41,959 | Roy Oswalt | Noah Lowry | Noah Lowry | Roy Oswalt | | 468 | 423 | 45 |
| 2005-08-07 | @ SFN | 112 | W 8-1 | - | | 42,947 | Roger Clemens | Brian Cooper | Roger Clemens | Scott Eyre | | 476 | 424 | 52 |
| 2005-08-09 | vs WAS | 113 | L 5-6 | - | | 34,255 | Ezequiel Astacio | John Patterson | John Patterson | Ezequiel Astacio | Chad Cordero | 481 | 430 | 51 |
| 2005-08-10 | vs WAS | 114 | W 7-6 | - | | 34,309 | Wandy Rodriguez | Livan Hernandez | Wandy Rodriguez | Livan Hernandez | Brad Lidge | 488 | 436 | 52 |
| 2005-08-11 | vs WAS | 115 | W 6-3 | - | | 35,036 | Andy Pettitte | Ryan Drese | Andy Pettitte | Ryan Drese | | 494 | 439 | 55 |
| 2005-08-12 | vs PIT | 116 | W 6-5 | - | | 37,524 | Roy Oswalt | Zach Duke | Dan Wheeler | Rick White | Brad Lidge | 500 | 444 | 56 |
| 2005-08-13 | vs PIT | 117 | L 0-1 | - | | 43,286 | Roger Clemens | Kip Wells | Salomon Torres | Brad Lidge | Jose Mesa | 500 | 445 | 55 |
| 2005-08-14 | vs PIT | 118 | L 0-8 | - | | 36,872 | Ezequiel Astacio | David Williams | David Williams | Ezequiel Astacio | | 500 | 453 | 47 |
| 2005-08-15 | vs CHN | 119 | W 12-4 | - | | 26,992 | Wandy Rodriguez | Glendon Rusch | Wandy Rodriguez | Glendon Rusch | | 512 | 457 | 55 |
| 2005-08-16 | vs CHN | 120 | L 1-4 | - | | 31,963 | Andy Pettitte | Greg Maddux | Greg Maddux | Andy Pettitte | Ryan Dempster | 513 | 461 | 52 |
| 2005-08-17 | vs CHN | 121 | L 2-4 | - | | 29,978 | Roy Oswalt | Carlos Zambrano | Carlos Zambrano | Roy Oswalt | Ryan Dempster | 515 | 465 | 50 |
| 2005-08-18 | vs MIL | 122 | L 2-5 | - | | 29,844 | Roger Clemens | Tomo Ohka | Tomo Ohka | Roger Clemens | Derrick Turnbow | 517 | 470 | 47 |
| 2005-08-19 | vs MIL | 123 | W 5-3 | - | | 31,651 | Ezequiel Astacio | Doug Davis | Russ Springer | Doug Davis | Brad Lidge | 522 | 473 | 49 |
| 2005-08-20 | vs MIL | 124 | L 2-3 | - | | 41,101 | Wandy Rodriguez | Ben Sheets | Ben Sheets | Chad Harville | | 524 | 476 | 48 |
| 2005-08-21 | vs MIL | 125 | W 8-3 | - | | 35,712 | Andy Pettitte | Victor Santos | Andy Pettitte | Victor Santos | | 532 | 479 | 53 |
| 2005-08-22 | @ SDN | 126 | W 6-2 | - | | 33,991 | Roy Oswalt | Woody Williams | Roy Oswalt | Woody Williams | | 538 | 481 | 57 |
| 2005-08-23 | @ SDN | 127 | L 0-2 | - | | 37,985 | Roger Clemens | Jake Peavy | Jake Peavy | Roger Clemens | | 538 | 483 | 55 |
| 2005-08-24 | @ SDN | 128 | L 4-7 | - | | 30,928 | Ezequiel Astacio | Chan Ho Park | Chan Ho Park | Wandy Rodriguez | Trevor Hoffman | 542 | 490 | 52 |
| 2005-08-26 | @ LAN | 129 | W 2-1 | - | | 41,638 | Andy Pettitte | Derek Lowe | Andy Pettitte | Derek Lowe | Brad Lidge | 544 | 491 | 53 |
| 2005-08-27 | @ LAN | 130 | L 3-8 | - | | 51,738 | Roy Oswalt | Edwin Jackson | Edwin Jackson | Roy Oswalt | | 547 | 499 | 48 |
| 2005-08-28 | @ LAN | 131 | L 0-1 | - | | 47,541 | Roger Clemens | Jeff Weaver | Jeff Weaver | Chad Qualls | Duaner Sanchez | 547 | 500 | 47 |
| 2005-08-30 | vs CIN | 132 | W 5-2 | - | | 29,971 | Wandy Rodriguez | Ramon Ortiz | Wandy Rodriguez | Ramon Ortiz | | 552 | 502 | 50 |
| 2005-08-31 | vs CIN | 133 | W 10-0 | - | | 28,639 | Andy Pettitte | Brandon Claussen | Andy Pettitte | Brandon Claussen | | 562 | 502 | 60 |
| 2005-09-01 | vs CIN | 134 | W 3-1 | - | | 27,490 | Roy Oswalt | Aaron Harang | Roy Oswalt | Aaron Harang | Brad Lidge | 565 | 503 | 62 |
| 2005-09-02 | vs SLN | 135 | W 6-5 | - | | 38,511 | Ezequiel Astacio | Mark Mulder | Chad Qualls | Julian Tavarez | | 571 | 508 | 63 |
| 2005-09-03 | vs SLN | 136 | L 2-4 | - | | 42,817 | Roger Clemens | Chris Carpenter | Chris Carpenter | Russ Springer | | 573 | 512 | 61 |
| 2005-09-04 | vs SLN | 137 | L 1-4 | - | | 38,277 | Wandy Rodriguez | Jason Marquis | Jason Marquis | Wandy Rodriguez | | 574 | 516 | 58 |
| 2005-09-05 | @ PHI | 138 | W 4-3 | - | | 36,144 | Andy Pettitte | Brett Myers | Andy Pettitte | Brett Myers | Brad Lidge | 578 | 519 | 59 |
| 2005-09-06 | @ PHI | 139 | W 2-1 | - | | 30,600 | Roy Oswalt | Jon Lieber | Roy Oswalt | Billy Wagner | Brad Lidge | 580 | 520 | 60 |
| 2005-09-07 | @ PHI | 140 | W 8-6 | - | | 29,026 | Brandon Backe | Vicente Padilla | Chad Qualls | Billy Wagner | Brad Lidge | 588 | 526 | 62 |
| 2005-09-09 | @ MIL | 141 | L 4-7 | - | | 18,130 | Roger Clemens | Doug Davis | Doug Davis | Roger Clemens | Derrick Turnbow | 592 | 533 | 59 |
| 2005-09-10 | @ MIL | 142 | W 7-5 | - | | 24,437 | Andy Pettitte | Tomo Ohka | Andy Pettitte | Tomo Ohka | Brad Lidge | 599 | 538 | 61 |
| 2005-09-11 | @ MIL | 143 | L 2-4 | - | | 17,392 | Roy Oswalt | Rick Helling | Rick Helling | Roy Oswalt | Derrick Turnbow | 601 | 542 | 59 |
| 2005-09-12 | vs FLO | 144 | L 2-8 | - | | 27,538 | Brandon Backe | Dontrelle Willis | Dontrelle Willis | Brandon Backe | | 603 | 550 | 53 |
| 2005-09-13 | vs FLO | 145 | L 2-4 | - | | 31,512 | Wandy Rodriguez | Josh Beckett | Josh Beckett | Wandy Rodriguez | Todd Jones | 605 | 554 | 51 |
| 2005-09-14 | vs FLO | 146 | W 10-2 | - | | 30,911 | Roger Clemens | A.J. Burnett | Roger Clemens | A.J. Burnett | | 615 | 556 | 59 |
| 2005-09-15 | vs FLO | 147 | W 4-1 | - | | 35,960 | Andy Pettitte | Jason Vargas | Andy Pettitte | Jason Vargas | Brad Lidge | 619 | 557 | 62 |
| 2005-09-16 | vs MIL | 148 | W 2-1 | - | | 33,767 | Roy Oswalt | Rick Helling | Brad Lidge | Dana Eveland | | 621 | 558 | 63 |
| 2005-09-17 | vs MIL | 149 | W 7-0 | - | | 37,756 | Brandon Backe | Wes Obermueller | Brandon Backe | Wes Obermueller | | 628 | 558 | 70 |
| 2005-09-18 | vs MIL | 150 | W 6-1 | - | | 35,052 | Wandy Rodriguez | Chris Capuano | Wandy Rodriguez | Chris Capuano | | 634 | 559 | 75 |
| 2005-09-19 | @ PIT | 151 | L 0-7 | - | | 13,865 | Roger Clemens | Ian Snell | Ian Snell | Roger Clemens | | 634 | 566 | 68 |
| 2005-09-20 | @ PIT | 152 | W 7-4 | - | | 12,927 | Andy Pettitte | Tom Gorzelanny | Andy Pettitte | Tom Gorzelanny | | 641 | 570 | 71 |
| 2005-09-21 | @ PIT | 153 | W 12-8 | - | | 16,266 | Roy Oswalt | Kip Wells | Roy Oswalt | Kip Wells | | 653 | 578 | 75 |
| 2005-09-22 | @ PIT | 154 | W 2-1 | - | | 12,587 | Brandon Backe | Zach Duke | Brandon Backe | Zach Duke | Brad Lidge | 655 | 579 | 76 |
| 2005-09-23 | @ CHN | 155 | L 4-5 | - | | 38,622 | Wandy Rodriguez | Glendon Rusch | Glendon Rusch | Wandy Rodriguez | Ryan Dempster | 659 | 584 | 75 |
| 2005-09-24 | @ CHN | 156 | W 8-3 | - | | 39,263 | Ezequiel Astacio | Carlos Zambrano | Ezequiel Astacio | Carlos Zambrano | | 667 | 587 | 80 |
| 2005-09-25 | @ CHN | 157 | L 2-3 | - | | 38,121 | Andy Pettitte | Jerome Williams | Jerome Williams | Mike Gallo | Ryan Dempster | 669 | 590 | 79 |
| 2005-09-27 | @ SLN | 158 | W 3-1 | - | | 40,260 | Roy Oswalt | Matt Morris | Roy Oswalt | Matt Morris | Brad Lidge | 672 | 591 | 81 |
| 2005-09-28 | @ SLN | 159 | W 7-6 | - | | 40,616 | Brandon Backe | Chris Carpenter | Chad Qualls | Jason Isringhausen | Brad Lidge | 679 | 597 | 82 |
| 2005-09-29 | vs CHN | 160 | L 2-3 | - | | 37,820 | Wandy Rodriguez | Glendon Rusch | Glendon Rusch | Wandy Rodriguez | Ryan Dempster | 681 | 600 | 81 |
| 2005-09-30 | vs CHN | 161 | L 3-4 | - | | 41,304 | Andy Pettitte | Carlos Zambrano | Roberto Novoa | Brad Lidge | Ryan Dempster | 684 | 604 | 80 |
| 2005-10-01 | vs CHN | 162 | W 3-1 | - | | 42,021 | Roger Clemens | Jerome Williams | Roger Clemens | Jerome Williams | Brad Lidge | 687 | 605 | 82 |
| 2005-10-02 | vs CHN | 163 | W 6-4 | - | | 42,288 | Roy Oswalt | Greg Maddux | Roy Oswalt | Greg Maddux | Brad Lidge | 693 | 609 | 84 |