| 2005-04-04 | vs KCA | 1 | W 11-2 | 1-0 | 2 | 44,105 | Jeremy Bonderman | Jose Lima | Jeremy Bonderman | Jose Lima | | 11 | 2 | 9 |
| 2005-04-06 | vs KCA | 2 | L 2-7 | 1-1 | 3 | 14,168 | Mike Maroth | Runelvys Hernandez | Runelvys Hernandez | Mike Maroth | | 13 | 9 | 4 |
| 2005-04-07 | vs KCA | 3 | W 7-3 | 2-1 | 2 | 10,463 | Jason Johnson | Zack Greinke | Jason Johnson | Mike Wood | | 20 | 12 | 8 |
| 2005-04-08 | vs CLE | 4 | L 3-4 | 2-2 | 3 | 23,294 | Nate Robertson | Scott Elarton | David Riske | Ugueth Urbina | Bob Wickman | 23 | 16 | 7 |
| 2005-04-09 | vs CLE | 5 | W 11-1 | 3-2 | 2 | 26,037 | Wil Ledezma | Jake Westbrook | Wil Ledezma | Jake Westbrook | | 34 | 17 | 17 |
| 2005-04-10 | vs CLE | 6 | L 6-7 | 3-3 | 3 | 25,758 | Jeremy Bonderman | Jason Davis | Jason Davis | Jeremy Bonderman | Bob Wickman | 40 | 24 | 16 |
| 2005-04-12 | @ MIN | 7 | L 4-5 | 3-4 | 4 | 15,071 | Mike Maroth | Joe Mays | Juan Rincon | Troy Percival | | 44 | 29 | 15 |
| 2005-04-13 | @ MIN | 8 | L 4-8 | 3-5 | 4 | 16,067 | Jason Johnson | Kyle Lohse | Kyle Lohse | Jason Johnson | | 48 | 37 | 11 |
| 2005-04-14 | @ MIN | 9 | L 4-10 | 3-6 | 4 | 14,344 | Nate Robertson | Brad Radke | Brad Radke | Nate Robertson | | 52 | 47 | 5 |
| 2005-04-15 | @ KCA | 10 | L 5-6 | 3-7 | 5 | 29,720 | Wil Ledezma | Jose Lima | Jaime Cerda | Ugueth Urbina | Mike MacDougal | 57 | 53 | 4 |
| 2005-04-16 | @ KCA | 11 | W 7-1 | 4-7 | 4 | 22,881 | Jeremy Bonderman | Brian Anderson | Jeremy Bonderman | Brian Anderson | | 64 | 54 | 10 |
| 2005-04-17 | @ KCA | 12 | W 6-1 | 5-7 | 4 | 14,904 | Mike Maroth | Runelvys Hernandez | Mike Maroth | Runelvys Hernandez | | 70 | 55 | 15 |
| 2005-04-18 | @ BAL | 13 | W 13-3 | 6-7 | 4 | 16,301 | Jason Johnson | Erik Bedard | Jason Johnson | Erik Bedard | | 83 | 58 | 25 |
| 2005-04-19 | @ BAL | 14 | L 4-8 | 6-8 | 4 | 18,009 | Nate Robertson | Sidney Ponson | Sidney Ponson | Nate Robertson | | 87 | 66 | 21 |
| 2005-04-20 | vs CHA | 15 | L 1-9 | 6-9 | 4 | 16,887 | Wil Ledezma | Jon Garland | Jon Garland | Wil Ledezma | | 88 | 75 | 13 |
| 2005-04-21 | vs CHA | 16 | L 3-4 | 6-10 | 4 | 19,334 | Jeremy Bonderman | Mark Buehrle | Mark Buehrle | Jeremy Bonderman | Shingo Takatsu | 91 | 79 | 12 |
| 2005-04-22 | vs MIN | 17 | W 5-4 | 7-10 | 4 | 18,873 | Mike Maroth | Carlos Silva | Troy Percival | Terry Mulholland | | 96 | 83 | 13 |
| 2005-04-25 | vs MIN | 18 | W 6-4 | 8-10 | 3 | 14,976 | Jason Johnson | Brad Radke | Kyle Farnsworth | Juan Rincon | Troy Percival | 102 | 87 | 15 |
| 2005-04-27 | @ CLE | 19 | W 10-3 | 9-10 | 3 | 12,162 | Jeremy Bonderman | Jake Westbrook | Jeremy Bonderman | Jake Westbrook | | 112 | 90 | 22 |
| 2005-04-28 | @ CLE | 20 | W 3-2 | 10-10 | 3 | 13,809 | Mike Maroth | Kevin Millwood | Mike Maroth | Kevin Millwood | Troy Percival | 115 | 92 | 23 |
| 2005-04-29 | @ CHA | 21 | W 3-2 | 11-10 | 3 | 18,313 | Nate Robertson | Jose Contreras | Jamie Walker | Shingo Takatsu | Franklyn German | 118 | 94 | 24 |
| 2005-04-30 | @ CHA | 22 | L 3-4 | 11-11 | 3 | 30,189 | Jason Johnson | Orlando Hernandez | Orlando Hernandez | Jason Johnson | Dustin Hermanson | 121 | 98 | 23 |
| 2005-05-01 | @ CHA | 23 | L 0-8 | 11-12 | 3 | 20,862 | Wil Ledezma | Jon Garland | Jon Garland | Wil Ledezma | | 121 | 106 | 15 |
| 2005-05-02 | vs BOS | 24 | W 8-3 | 12-12 | 3 | 17,497 | Jeremy Bonderman | Geremi Gonzalez | Jeremy Bonderman | Blaine Neal | Ugueth Urbina | 129 | 109 | 20 |
| 2005-05-03 | vs BOS | 25 | L 3-5 | 12-13 | 3 | 19,121 | Mike Maroth | John Halama | John Halama | Mike Maroth | Keith Foulke | 132 | 114 | 18 |
| 2005-05-04 | vs BOS | 26 | L 3-4 | 12-14 | 3 | 23,295 | Nate Robertson | Tim Wakefield | Tim Wakefield | Kyle Farnsworth | Keith Foulke | 135 | 118 | 17 |
| 2005-05-05 | vs BOS | 27 | L 1-2 | 12-15 | 3 | 24,870 | Jason Johnson | Bronson Arroyo | Bronson Arroyo | Ugueth Urbina | Keith Foulke | 136 | 120 | 16 |
| 2005-05-06 | @ ANA | 28 | L 3-4 | 12-16 | 4 | 44,022 | Wil Ledezma | Kelvim Escobar | Kelvim Escobar | Wil Ledezma | Francisco Rodriguez | 139 | 124 | 15 |
| 2005-05-07 | @ ANA | 29 | W 2-1 | 13-16 | 3 | 43,876 | Jeremy Bonderman | Bartolo Colon | Jeremy Bonderman | Bartolo Colon | Troy Percival | 141 | 125 | 16 |
| 2005-05-08 | @ ANA | 30 | W 10-1 | 14-16 | 3 | 43,587 | Mike Maroth | Jarrod Washburn | Mike Maroth | Jarrod Washburn | | 151 | 126 | 25 |
| 2005-05-09 | @ TEX | 31 | W 2-0 | 15-16 | 3 | 24,122 | Nate Robertson | Chris Young | Nate Robertson | Francisco Cordero | Ugueth Urbina | 153 | 126 | 27 |
| 2005-05-10 | @ TEX | 32 | L 4-5 | 15-17 | 3 | 24,766 | Jason Johnson | Chan Ho Park | Doug Brocail | Jason Johnson | Francisco Cordero | 157 | 131 | 26 |
| 2005-05-11 | @ TEX | 33 | W 6-5 | 16-17 | 3 | 28,689 | Wil Ledezma | Pedro Astacio | Jamie Walker | Ron Mahay | Ugueth Urbina | 163 | 136 | 27 |
| 2005-05-14 | vs ANA | 34 | L 2-4 | 17-18 | 3 | 0 | Jeremy Bonderman | Bartolo Colon | Brendan Donnelly | Jamie Walker | Francisco Rodriguez | 165 | 140 | 25 |
| 2005-05-14 | vs ANA | 35 | W 3-2 | 17-18 | 3 | 33,380 | Mike Maroth | Jarrod Washburn | Mike Maroth | Jarrod Washburn | Ugueth Urbina | 168 | 142 | 26 |
| 2005-05-15 | vs ANA | 36 | L 3-9 | 17-19 | 3 | 23,107 | Nate Robertson | John Lackey | John Lackey | Nate Robertson | | 171 | 151 | 20 |
| 2005-05-17 | vs TBA | 37 | W 4-3 | 18-19 | 3 | 15,955 | Jason Johnson | Casey Fossum | Franklyn German | Travis Harper | | 175 | 154 | 21 |
| 2005-05-18 | vs TBA | 38 | W 6-4 | 19-19 | 3 | 17,414 | Wil Ledezma | Doug Waechter | Wil Ledezma | Doug Waechter | Ugueth Urbina | 181 | 158 | 23 |
| 2005-05-19 | vs TBA | 39 | L 2-6 | 19-20 | 3 | 20,355 | Mike Maroth | Scott Kazmir | Scott Kazmir | Mike Maroth | Danys Baez | 183 | 164 | 19 |
| 2005-05-20 | vs ARI | 40 | L 2-6 | 19-21 | 3 | 30,119 | Jeremy Bonderman | Brandon Webb | Brandon Webb | Jamie Walker | Brian Bruney | 185 | 170 | 15 |
| 2005-05-21 | vs ARI | 41 | W 3-2 | 20-21 | 3 | 30,134 | Nate Robertson | Shawn Estes | Franklyn German | Brian Bruney | | 188 | 172 | 16 |
| 2005-05-22 | vs ARI | 42 | L 0-1 | 20-22 | 3 | 23,124 | Jason Johnson | Javier Vazquez | Javier Vazquez | Jason Johnson | | 188 | 173 | 15 |
| 2005-05-24 | @ NYA | 43 | L 3-12 | 20-23 | 3 | 37,099 | Wil Ledezma | Mike Mussina | Mike Mussina | Wil Ledezma | | 191 | 185 | 6 |
| 2005-05-25 | @ NYA | 44 | L 2-4 | 20-24 | 4 | 51,833 | Mike Maroth | Chien-Ming Wang | Chien-Ming Wang | Mike Maroth | Mariano Rivera | 193 | 189 | 4 |
| 2005-05-26 | @ NYA | 45 | L 3-4 | 20-25 | 4 | 42,835 | Jeremy Bonderman | Kevin Brown | Kevin Brown | Jeremy Bonderman | Mariano Rivera | 196 | 193 | 3 |
| 2005-05-27 | @ BAL | 46 | W 4-3 | 21-25 | 4 | 34,175 | Nate Robertson | Sidney Ponson | Nate Robertson | Sidney Ponson | Ugueth Urbina | 200 | 196 | 4 |
| 2005-05-28 | @ BAL | 47 | W 5-3 | 22-25 | 4 | 35,955 | Jason Johnson | Hayden Penn | Jason Johnson | Jorge Julio | Ugueth Urbina | 205 | 199 | 6 |
| 2005-05-29 | @ BAL | 48 | W 8-6 | 23-25 | 4 | 37,061 | Wil Ledezma | Bruce Chen | Chris Spurling | Steve Reed | Ugueth Urbina | 213 | 205 | 8 |
| 2005-05-31 | vs TEX | 49 | L 2-8 | 23-26 | 4 | 16,931 | Mike Maroth | Kenny Rogers | Kenny Rogers | Mike Maroth | | 215 | 213 | 2 |
| 2005-06-01 | vs TEX | 50 | W 6-4 | 24-26 | 4 | 15,428 | Jeremy Bonderman | Ryan Drese | Jeremy Bonderman | Ryan Drese | Ugueth Urbina | 221 | 217 | 4 |
| 2005-06-02 | vs TEX | 51 | W 6-5 | 25-26 | 3 | 21,166 | Nate Robertson | Chris Young | Ugueth Urbina | Nick Regilio | | 227 | 222 | 5 |
| 2005-06-03 | vs BAL | 52 | W 5-3 | 26-26 | 3 | 30,784 | Jason Johnson | Bruce Chen | Jason Johnson | Bruce Chen | Kyle Farnsworth | 232 | 225 | 7 |
| 2005-06-04 | vs BAL | 53 | L 7-14 | 26-27 | 3 | 33,451 | Wil Ledezma | Rodrigo Lopez | Steve Reed | Jamie Walker | | 239 | 239 | 0 |
| 2005-06-05 | vs BAL | 54 | L 2-6 | 26-28 | 3 | 28,252 | Mike Maroth | Daniel Cabrera | Daniel Cabrera | Mike Maroth | | 241 | 245 | -4 |
| 2005-06-06 | @ LAN | 55 | L 3-5 | 26-29 | 4 | 33,518 | Jeremy Bonderman | Derek Lowe | Derek Lowe | Jeremy Bonderman | Eric Gagne | 244 | 250 | -6 |
| 2005-06-07 | @ LAN | 56 | W 8-4 | 27-29 | 4 | 32,314 | Nate Robertson | Derek Thompson | Chris Spurling | Duaner Sanchez | | 252 | 254 | -2 |
| 2005-06-08 | @ LAN | 57 | L 1-3 | 27-30 | 4 | 34,690 | Jason Johnson | Jeff Weaver | Jeff Weaver | Jason Johnson | Eric Gagne | 253 | 257 | -4 |
| 2005-06-10 | @ COL | 58 | L 0-2 | 27-31 | 4 | 20,275 | Mike Maroth | Jamey Wright | Jamey Wright | Mike Maroth | Brian Fuentes | 253 | 259 | -6 |
| 2005-06-11 | @ COL | 59 | W 6-4 | 28-31 | 4 | 30,192 | Jeremy Bonderman | Jason Jennings | Jeremy Bonderman | Jason Jennings | Troy Percival | 259 | 263 | -4 |
| 2005-06-12 | @ COL | 60 | L 3-7 | 28-32 | 4 | 22,078 | Nate Robertson | Byung-Hyun Kim | Byung-Hyun Kim | Nate Robertson | | 262 | 270 | -8 |
| 2005-06-14 | vs SDN | 61 | W 8-4 | 29-32 | 4 | 19,585 | Jason Johnson | Jake Peavy | Fernando Rodney | Jake Peavy | | 270 | 274 | -4 |
| 2005-06-15 | vs SDN | 62 | W 8-2 | 30-32 | 4 | 21,895 | Mike Maroth | Adam Eaton | Mike Maroth | Adam Eaton | | 278 | 276 | 2 |
| 2005-06-16 | vs SDN | 63 | W 3-1 | 31-32 | 4 | 21,429 | Jeremy Bonderman | Woody Williams | Jeremy Bonderman | Woody Williams | Troy Percival | 281 | 277 | 4 |
| 2005-06-17 | vs SFN | 64 | L 0-4 | 31-33 | 4 | 34,397 | Nate Robertson | Jason Schmidt | Jason Schmidt | Nate Robertson | Tyler Walker | 281 | 281 | 0 |
| 2005-06-18 | vs SFN | 65 | W 8-2 | 32-33 | 4 | 38,461 | Jason Johnson | Kirk Rueter | Jason Johnson | Kirk Rueter | | 289 | 283 | 6 |
| 2005-06-19 | vs SFN | 66 | W 10-8 | 33-33 | 4 | 35,191 | Mike Maroth | Jesse Foppert | Jamie Walker | Scott Eyre | | 299 | 291 | 8 |
| 2005-06-21 | @ MIN | 67 | W 7-2 | 34-33 | 4 | 20,839 | Jeremy Bonderman | Kyle Lohse | Jeremy Bonderman | Kyle Lohse | | 306 | 293 | 13 |
| 2005-06-22 | @ MIN | 68 | W 8-1 | 35-33 | 4 | 24,114 | Nate Robertson | Joe Mays | Nate Robertson | Joe Mays | | 314 | 294 | 20 |
| 2005-06-23 | @ MIN | 69 | L 2-6 | 35-34 | 4 | 20,517 | Jason Johnson | Carlos Silva | Carlos Silva | Jason Johnson | | 316 | 300 | 16 |
| 2005-06-24 | @ ARI | 70 | L 1-2 | 35-35 | 4 | 24,808 | Mike Maroth | Shawn Estes | Shawn Estes | Mike Maroth | Brian Bruney | 317 | 302 | 15 |
| 2005-06-25 | @ ARI | 71 | W 5-1 | 36-35 | 4 | 27,344 | Sean Douglass | Javier Vazquez | Sean Douglass | Javier Vazquez | | 322 | 303 | 19 |
| 2005-06-26 | @ ARI | 72 | L 7-13 | 36-36 | 4 | 25,720 | Jeremy Bonderman | Claudio Vargas | Claudio Vargas | Jeremy Bonderman | | 329 | 316 | 13 |
| 2005-06-28 | vs CHA | 73 | L 1-2 | 36-37 | 4 | 23,602 | Nate Robertson | Mark Buehrle | Mark Buehrle | Nate Robertson | Dustin Hermanson | 330 | 318 | 12 |
| 2005-06-29 | vs CHA | 74 | L 3-4 | 36-38 | 4 | 19,931 | Jason Johnson | Brandon McCarthy | Shingo Takatsu | Fernando Rodney | | 333 | 322 | 11 |
| 2005-06-30 | vs CHA | 75 | L 1-6 | 36-39 | 4 | 23,447 | Mike Maroth | Freddy Garcia | Freddy Garcia | Mike Maroth | | 334 | 328 | 6 |
| 2005-07-01 | vs NYA | 76 | W 10-2 | 37-39 | 4 | 40,776 | Jeremy Bonderman | Randy Johnson | Jeremy Bonderman | Randy Johnson | | 344 | 330 | 14 |
| 2005-07-02 | vs NYA | 77 | L 4-8 | 37-40 | 4 | 41,207 | Sean Douglass | Mike Mussina | Tom Gordon | Troy Percival | | 348 | 338 | 10 |
| 2005-07-03 | vs NYA | 78 | L 0-1 | 37-41 | 4 | 40,056 | Nate Robertson | Chien-Ming Wang | Chien-Ming Wang | Nate Robertson | Mariano Rivera | 348 | 339 | 9 |
| 2005-07-04 | @ CLE | 79 | L 3-9 | 37-43 | 4 | 26,869 | Jason Johnson | Scott Elarton | Scott Elarton | Jason Johnson | | 351 | 348 | 3 |
| 2005-07-04 | @ CLE | 80 | L 0-6 | 37-43 | 4 | 33,599 | Justin Verlander | Jason Davis | Jason Davis | Justin Verlander | | 351 | 354 | -3 |
| 2005-07-05 | @ CLE | 81 | W 3-2 | 38-43 | 4 | 18,478 | Mike Maroth | Jake Westbrook | Mike Maroth | Jake Westbrook | Troy Percival | 354 | 356 | -2 |
| 2005-07-06 | @ CLE | 82 | W 7-3 | 39-43 | 4 | 22,539 | Jeremy Bonderman | CC Sabathia | Jeremy Bonderman | CC Sabathia | Troy Percival | 361 | 359 | 2 |
| 2005-07-07 | @ TBA | 83 | W 6-4 | 40-43 | 4 | 9,174 | Sean Douglass | Seth McClung | Sean Douglass | Seth McClung | Troy Percival | 367 | 363 | 4 |
| 2005-07-08 | @ TBA | 84 | W 7-3 | 41-43 | 4 | 10,582 | Nate Robertson | Scott Kazmir | Franklyn German | Scott Kazmir | | 374 | 366 | 8 |
| 2005-07-09 | @ TBA | 85 | L 4-5 | 41-44 | 4 | 9,320 | Jason Johnson | Hideo Nomo | Danys Baez | Troy Percival | | 378 | 371 | 7 |
| 2005-07-10 | @ TBA | 86 | W 9-4 | 42-44 | 4 | 15,223 | Mike Maroth | Mark Hendrickson | Mike Maroth | Mark Hendrickson | | 387 | 375 | 12 |
| 2005-07-14 | vs KCA | 87 | L 9-12 | 42-45 | 4 | 18,922 | Jeremy Bonderman | Zack Greinke | Zack Greinke | Jeremy Bonderman | Mike MacDougal | 396 | 387 | 9 |
| 2005-07-15 | vs KCA | 88 | W 4-1 | 43-45 | 4 | 30,807 | Nate Robertson | Jose Lima | Nate Robertson | Jose Lima | Kyle Farnsworth | 400 | 388 | 12 |
| 2005-07-16 | vs KCA | 89 | W 5-3 | 44-45 | 4 | 29,482 | Jason Johnson | J.P. Howell | Jason Johnson | Mike Wood | Kyle Farnsworth | 405 | 391 | 14 |
| 2005-07-17 | vs KCA | 90 | L 0-5 | 44-46 | 4 | 24,166 | Mike Maroth | Runelvys Hernandez | Runelvys Hernandez | Mike Maroth | | 405 | 396 | 9 |
| 2005-07-18 | @ CHA | 91 | L 5-7 | 44-47 | 4 | 37,556 | Sean Douglass | Orlando Hernandez | Luis Vizcaino | Chris Spurling | Cliff Politte | 410 | 403 | 7 |
| 2005-07-19 | @ CHA | 92 | W 7-1 | 45-47 | 4 | 31,008 | Jeremy Bonderman | Jose Contreras | Jeremy Bonderman | Jose Contreras | | 417 | 404 | 13 |
| 2005-07-20 | @ CHA | 93 | W 8-6 | 46-47 | 4 | 39,146 | Nate Robertson | Freddy Garcia | Nate Robertson | Freddy Garcia | Craig Dingman | 425 | 410 | 15 |
| 2005-07-21 | vs MIN | 94 | L 5-10 | 46-48 | 4 | 23,769 | Jason Johnson | Johan Santana | Johan Santana | Jason Johnson | | 430 | 420 | 10 |
| 2005-07-22 | vs MIN | 95 | W 12-6 | 47-48 | 4 | 34,526 | Mike Maroth | Joe Mays | Mike Maroth | Joe Mays | | 442 | 426 | 16 |
| 2005-07-23 | vs MIN | 96 | W 2-1 | 48-49 | 4 | 20,206 | Sean Douglass | Carlos Silva | Sean Douglass | Carlos Silva | Kyle Farnsworth | 444 | 427 | 17 |
| 2005-07-23 | vs MIN | 97 | L 2-5 | 48-49 | 4 | 34,388 | Justin Verlander | Scott Baker | Scott Baker | Justin Verlander | Joe Nathan | 446 | 432 | 14 |
| 2005-07-24 | vs MIN | 98 | W 5-2 | 49-49 | 4 | 27,966 | Jeremy Bonderman | Kyle Lohse | Jeremy Bonderman | Kyle Lohse | Kyle Farnsworth | 451 | 434 | 17 |
| 2005-07-25 | @ SEA | 99 | L 3-5 | 49-50 | 4 | 27,102 | Nate Robertson | Ryan Franklin | J.J. Putz | Nate Robertson | Eddie Guardado | 454 | 439 | 15 |
| 2005-07-26 | @ SEA | 100 | W 8-5 | 50-50 | 4 | 30,644 | Jason Johnson | Joel Pineiro | Jason Johnson | Julio Mateo | Kyle Farnsworth | 462 | 444 | 18 |
| 2005-07-27 | @ SEA | 101 | L 3-9 | 50-51 | 4 | 29,323 | Mike Maroth | Jamie Moyer | Jamie Moyer | Mike Maroth | | 465 | 453 | 12 |
| 2005-07-29 | @ OAK | 102 | L 4-8 | 50-52 | 4 | 20,563 | Sean Douglass | Rich Harden | Rich Harden | Sean Douglass | | 469 | 461 | 8 |
| 2005-07-30 | @ OAK | 103 | L 5-9 | 50-53 | 4 | 25,265 | Nate Robertson | Barry Zito | Barry Zito | Nate Robertson | Jay Witasick | 474 | 470 | 4 |
| 2005-07-31 | @ OAK | 104 | L 2-5 | 50-54 | 4 | 30,057 | Jeremy Bonderman | Kirk Saarloos | Kirk Saarloos | Jeremy Bonderman | | 476 | 475 | 1 |
| 2005-08-02 | vs SEA | 105 | L 1-4 | 50-55 | 4 | 30,306 | Jason Johnson | Jorge Campillo | Julio Mateo | Jason Johnson | Eddie Guardado | 477 | 479 | -2 |
| 2005-08-03 | vs SEA | 106 | W 10-7 | 51-55 | 4 | 26,760 | Mike Maroth | Gil Meche | Mike Maroth | Gil Meche | Fernando Rodney | 487 | 486 | 1 |
| 2005-08-04 | vs SEA | 107 | W 3-1 | 52-55 | 4 | 28,148 | Sean Douglass | Felix Hernandez | Sean Douglass | Felix Hernandez | Fernando Rodney | 490 | 487 | 3 |
| 2005-08-05 | vs CLE | 108 | L 6-9 | 52-56 | 4 | 38,928 | Nate Robertson | CC Sabathia | CC Sabathia | Nate Robertson | Bob Howry | 496 | 496 | 0 |
| 2005-08-06 | vs CLE | 109 | L 2-4 | 52-57 | 4 | 39,817 | Jeremy Bonderman | Jake Westbrook | Jake Westbrook | Jeremy Bonderman | Bob Wickman | 498 | 500 | -2 |
| 2005-08-07 | vs CLE | 110 | L 5-6 | 52-58 | 4 | 34,553 | Jason Johnson | Scott Elarton | David Riske | Fernando Rodney | Bob Wickman | 503 | 506 | -3 |
| 2005-08-08 | @ TOR | 111 | W 9-8 | 53-58 | 4 | 20,887 | Mike Maroth | David Bush | Vic Darensbourg | Scott Schoeneweis | Craig Dingman | 512 | 514 | -2 |
| 2005-08-09 | @ TOR | 112 | L 4-6 | 53-59 | 4 | 21,145 | Sean Douglass | Dustin McGowan | Dustin McGowan | Sean Douglass | Miguel Batista | 516 | 520 | -4 |
| 2005-08-10 | @ TOR | 113 | L 3-4 | 53-60 | 4 | 24,624 | Nate Robertson | Gustavo Chacin | Justin Speier | Craig Dingman | | 519 | 524 | -5 |
| 2005-08-11 | @ TOR | 114 | L 1-2 | 53-61 | 4 | 30,578 | Jeremy Bonderman | Scott Downs | Scott Downs | Jeremy Bonderman | Miguel Batista | 520 | 526 | -6 |
| 2005-08-14 | @ KCA | 115 | W 8-7 | 55-61 | 4 | 0 | Jason Johnson | Mike Wood | Craig Dingman | Ambiorix Burgos | Fernando Rodney | 528 | 533 | -5 |
| 2005-08-14 | @ KCA | 116 | W 1-0 | 55-61 | 4 | 17,568 | Mike Maroth | Jose Lima | Mike Maroth | Jose Lima | Fernando Rodney | 529 | 533 | -4 |
| 2005-08-15 | vs BOS | 117 | W 7-6 | 56-61 | 4 | 30,426 | Sean Douglass | Bronson Arroyo | Jamie Walker | Curt Schilling | | 536 | 539 | -3 |
| 2005-08-16 | vs BOS | 118 | L 7-10 | 56-62 | 4 | 32,129 | Nate Robertson | Jonathan Papelbon | Chad Bradford | Craig Dingman | | 543 | 549 | -6 |
| 2005-08-17 | vs BOS | 119 | W 6-5 | 57-62 | 4 | 30,634 | Jeremy Bonderman | David Wells | Jeremy Bonderman | David Wells | Fernando Rodney | 549 | 554 | -5 |
| 2005-08-19 | vs TOR | 120 | W 9-5 | 58-62 | 4 | 32,769 | Mike Maroth | David Bush | Mike Maroth | David Bush | Craig Dingman | 558 | 559 | -1 |
| 2005-08-20 | vs TOR | 121 | W 3-2 | 59-62 | 4 | 38,073 | Jason Johnson | Gustavo Chacin | Franklyn German | Miguel Batista | | 561 | 561 | 0 |
| 2005-08-21 | vs TOR | 122 | W 17-6 | 60-62 | 4 | 36,818 | Sean Douglass | Dustin McGowan | Sean Douglass | Dustin McGowan | | 578 | 567 | 11 |
| 2005-08-23 | vs OAK | 123 | W 4-1 | 61-62 | 4 | 24,467 | Nate Robertson | Dan Haren | Nate Robertson | Dan Haren | Fernando Rodney | 582 | 568 | 14 |
| 2005-08-24 | vs OAK | 124 | L 2-9 | 61-63 | 4 | 29,210 | Jeremy Bonderman | Kirk Saarloos | Kirk Saarloos | Jeremy Bonderman | | 584 | 577 | 7 |
| 2005-08-25 | vs OAK | 125 | L 1-11 | 61-64 | 4 | 24,440 | Mike Maroth | Barry Zito | Barry Zito | Mike Maroth | | 585 | 588 | -3 |
| 2005-08-26 | @ BOS | 126 | L 8-9 | 61-65 | 4 | 35,056 | Jason Johnson | Tim Wakefield | Tim Wakefield | Jason Johnson | Mike Timlin | 593 | 597 | -4 |
| 2005-08-27 | @ BOS | 127 | W 12-8 | 62-65 | 4 | 35,228 | Sean Douglass | Bronson Arroyo | Roman Colon | Jonathan Papelbon | | 605 | 605 | 0 |
| 2005-08-28 | @ BOS | 128 | L 3-11 | 62-66 | 4 | 34,568 | Nate Robertson | David Wells | David Wells | Nate Robertson | | 608 | 616 | -8 |
| 2005-08-29 | @ CLE | 129 | L 8-10 | 62-67 | 4 | 22,713 | Jeremy Bonderman | Scott Elarton | Fernando Cabrera | Jeremy Bonderman | Bob Wickman | 616 | 626 | -10 |
| 2005-08-31 | @ CLE | 130 | W 4-3 | 63-67 | 4 | 22,091 | Mike Maroth | Cliff Lee | Mike Maroth | Rafael Betancourt | Fernando Rodney | 620 | 629 | -9 |
| 2005-09-01 | @ CHA | 131 | L 3-12 | 63-68 | 4 | 20,743 | Jason Johnson | Jose Contreras | Jose Contreras | Jason Johnson | | 623 | 641 | -18 |
| 2005-09-02 | @ CHA | 132 | L 1-9 | 63-69 | 4 | 25,502 | Sean Douglass | Freddy Garcia | Freddy Garcia | Sean Douglass | | 624 | 650 | -26 |
| 2005-09-03 | @ CHA | 133 | L 2-6 | 63-70 | 4 | 30,509 | Nate Robertson | Mark Buehrle | Mark Buehrle | Nate Robertson | | 626 | 656 | -30 |
| 2005-09-04 | @ CHA | 134 | L 0-2 | 63-71 | 4 | 30,931 | Jeremy Bonderman | Jon Garland | Jon Garland | Jeremy Bonderman | | 626 | 658 | -32 |
| 2005-09-05 | vs CLE | 135 | L 0-2 | 63-72 | 4 | 26,150 | Mike Maroth | Scott Elarton | Scott Elarton | Mike Maroth | Bob Wickman | 626 | 660 | -34 |
| 2005-09-06 | vs CLE | 136 | L 1-6 | 63-73 | 4 | 15,308 | Jason Johnson | Cliff Lee | Cliff Lee | Jason Johnson | | 627 | 666 | -39 |
| 2005-09-07 | vs CLE | 137 | L 1-4 | 63-74 | 4 | 13,193 | Roman Colon | CC Sabathia | CC Sabathia | Roman Colon | | 628 | 670 | -42 |
| 2005-09-08 | @ CLE | 138 | L 2-4 | 63-75 | 4 | 20,363 | Nate Robertson | Kevin Millwood | Rafael Betancourt | Nate Robertson | Bob Wickman | 630 | 674 | -44 |
| 2005-09-09 | vs KCA | 139 | L 2-12 | 63-76 | 4 | 23,950 | Sean Douglass | Zack Greinke | Zack Greinke | Sean Douglass | | 632 | 686 | -54 |
| 2005-09-10 | vs KCA | 140 | W 4-3 | 64-76 | 4 | 25,242 | Mike Maroth | Jimmy Gobble | Chris Spurling | Andy Sisco | Fernando Rodney | 636 | 689 | -53 |
| 2005-09-11 | vs KCA | 141 | W 14-4 | 65-76 | 4 | 20,559 | Jason Johnson | Jose Lima | Jason Johnson | Jose Lima | | 650 | 693 | -43 |
| 2005-09-12 | vs MIN | 142 | L 1-2 | 65-77 | 4 | 12,748 | Roman Colon | Kyle Lohse | Kyle Lohse | Chris Spurling | Joe Nathan | 651 | 695 | -44 |
| 2005-09-13 | vs MIN | 143 | L 3-9 | 65-78 | 4 | 16,986 | Nate Robertson | Brad Radke | Brad Radke | Nate Robertson | | 654 | 704 | -50 |
| 2005-09-14 | vs MIN | 144 | W 4-2 | 66-78 | 4 | 19,438 | Sean Douglass | Francisco Liriano | Craig Dingman | Juan Rincon | | 658 | 706 | -48 |
| 2005-09-15 | @ ANA | 145 | W 8-6 | 67-78 | 4 | 41,962 | Mike Maroth | Bartolo Colon | Mike Maroth | Bartolo Colon | Craig Dingman | 666 | 712 | -46 |
| 2005-09-16 | @ ANA | 146 | L 6-7 | 67-79 | 4 | 43,144 | Jason Johnson | John Lackey | Kelvim Escobar | Vic Darensbourg | | 672 | 719 | -47 |
| 2005-09-17 | @ ANA | 147 | L 1-3 | 67-80 | 4 | 43,831 | Roman Colon | Ervin Santana | Ervin Santana | Chris Spurling | Francisco Rodriguez | 673 | 722 | -49 |
| 2005-09-18 | @ ANA | 148 | L 3-5 | 67-81 | 4 | 43,076 | Matt Ginter | Paul Byrd | Paul Byrd | Matt Ginter | Francisco Rodriguez | 676 | 727 | -51 |
| 2005-09-19 | @ KCA | 149 | L 4-10 | 67-82 | 4 | 8,915 | Jeremy Bonderman | Mike Wood | Mike Wood | Jeremy Bonderman | | 680 | 737 | -57 |
| 2005-09-20 | @ KCA | 150 | L 4-5 | 67-84 | 4 | 0 | Mike Maroth | J.P. Howell | Mike MacDougal | Craig Dingman | | 684 | 742 | -58 |
| 2005-09-20 | @ KCA | 151 | L 2-4 | 67-84 | 4 | 9,418 | Nate Robertson | Zack Greinke | Zack Greinke | Nate Robertson | Mike MacDougal | 686 | 746 | -60 |
| 2005-09-21 | @ KCA | 152 | L 3-4 | 67-85 | 4 | 8,640 | Jason Johnson | Jimmy Gobble | Kyle Snyder | Fernando Rodney | | 689 | 750 | -61 |
| 2005-09-23 | vs SEA | 153 | L 1-2 | 67-86 | 4 | 23,972 | Sean Douglass | Ryan Franklin | Ryan Franklin | Chris Spurling | Eddie Guardado | 690 | 752 | -62 |
| 2005-09-24 | vs SEA | 154 | W 7-1 | 68-86 | 4 | 25,328 | Jason Grilli | Jamie Moyer | Jason Grilli | Jamie Moyer | | 697 | 753 | -56 |
| 2005-09-25 | vs SEA | 155 | W 8-1 | 69-86 | 4 | 26,128 | Mike Maroth | Gil Meche | Mike Maroth | Shigetoshi Hasegawa | | 705 | 754 | -49 |
| 2005-09-26 | vs CHA | 156 | W 4-3 | 70-86 | 4 | 10,840 | Jason Johnson | Jon Garland | Fernando Rodney | Cliff Politte | | 709 | 757 | -48 |
| 2005-09-27 | vs CHA | 157 | W 3-2 | 71-86 | 4 | 13,983 | Nate Robertson | Brandon McCarthy | Nate Robertson | Brandon McCarthy | Fernando Rodney | 712 | 759 | -47 |
| 2005-09-28 | vs CHA | 158 | L 2-8 | 71-87 | 4 | 17,221 | Sean Douglass | Jose Contreras | Jose Contreras | Sean Douglass | | 714 | 767 | -53 |
| 2005-09-29 | vs CHA | 159 | L 2-4 | 71-88 | 4 | 13,494 | Jason Grilli | Freddy Garcia | Freddy Garcia | Jason Grilli | Bobby Jenks | 716 | 771 | -55 |
| 2005-09-30 | @ MIN | 160 | L 3-7 | 71-89 | 4 | 18,725 | Mike Maroth | Francisco Liriano | Francisco Liriano | Mike Maroth | | 719 | 778 | -59 |
| 2005-10-01 | @ MIN | 161 | L 0-3 | 71-90 | 4 | 28,292 | Jason Johnson | Scott Baker | Scott Baker | Jason Johnson | Joe Nathan | 719 | 781 | -62 |
| 2005-10-02 | @ MIN | 162 | L 4-6 | 71-91 | 4 | 20,160 | Nate Robertson | Johan Santana | Johan Santana | Nate Robertson | Joe Nathan | 723 | 787 | -64 |