| 2004-04-05 | @ MIN | 1 | L 4-7 | 0-1 | 5 | 49,584 | CC Sabathia | Brad Radke | Juan Rincon | Chad Durbin | | 4 | 7 | -3 |
| 2004-04-06 | @ MIN | 2 | L 6-7 | 0-2 | 5 | 19,832 | Jason Davis | Johan Santana | Joe Roa | Jake Westbrook | | 10 | 14 | -4 |
| 2004-04-07 | @ MIN | 3 | W 11-4 | 1-2 | 5 | 20,313 | Cliff Lee | Kyle Lohse | Chad Durbin | Kyle Lohse | | 21 | 18 | 3 |
| 2004-04-08 | @ KCA | 4 | W 6-1 | 2-2 | 2 | 14,671 | Jeff D'Amico | Jeremy Affeldt | Jeff D'Amico | Jeremy Affeldt | | 27 | 19 | 8 |
| 2004-04-09 | @ KCA | 5 | L 1-3 | 2-3 | 5 | 28,535 | Jason Stanford | Jimmy Gobble | Jason Grimsley | Jack Cressend | Curt Leskanic | 28 | 22 | 6 |
| 2004-04-10 | @ KCA | 6 | L 6-7 | 2-4 | 5 | 21,889 | CC Sabathia | Brian Anderson | Scott Sullivan | Rafael Betancourt | | 34 | 29 | 5 |
| 2004-04-11 | @ KCA | 7 | L 3-5 | 2-5 | 5 | 16,933 | Jason Davis | Dennys Reyes | Scott Sullivan | Jose Jimenez | Curt Leskanic | 37 | 34 | 3 |
| 2004-04-12 | vs MIN | 8 | W 6-3 | 3-5 | 5 | 42,424 | Cliff Lee | Kyle Lohse | Cliff Lee | Kyle Lohse | | 43 | 37 | 6 |
| 2004-04-14 | vs MIN | 9 | L 6-10 | 3-6 | 5 | 14,237 | Jeff D'Amico | Carlos Silva | Carlos Silva | Jeff D'Amico | Juan Rincon | 49 | 47 | 2 |
| 2004-04-15 | vs MIN | 10 | L 0-3 | 3-7 | 5 | 15,105 | Jason Stanford | Brad Radke | Brad Radke | Jason Stanford | Joe Nathan | 49 | 50 | -1 |
| 2004-04-16 | vs DET | 11 | W 10-3 | 4-7 | 5 | 18,507 | CC Sabathia | Nate Cornejo | CC Sabathia | Nate Cornejo | | 59 | 53 | 6 |
| 2004-04-17 | vs DET | 12 | L 1-6 | 4-8 | 5 | 18,955 | Jason Davis | Mike Maroth | Mike Maroth | Jason Davis | | 60 | 59 | 1 |
| 2004-04-18 | vs DET | 13 | W 9-7 | 5-8 | 4 | 19,240 | Cliff Lee | Jeremy Bonderman | Cliff Lee | Jeremy Bonderman | David Riske | 69 | 66 | 3 |
| 2004-04-19 | vs DET | 14 | L 4-10 | 5-9 | 4 | 13,650 | Jeff D'Amico | Nate Robertson | Al Levine | Rafael Betancourt | | 73 | 76 | -3 |
| 2004-04-20 | vs KCA | 15 | L 5-15 | 5-10 | 5 | 13,563 | Chad Durbin | Brian Anderson | Brian Anderson | Chad Durbin | | 78 | 91 | -13 |
| 2004-04-22 | vs KCA | 16 | W 5-4 | 6-10 | 4 | 15,720 | Jeff D'Amico | Jeremy Affeldt | Rafael Betancourt | Jason Grimsley | David Riske | 83 | 95 | -12 |
| 2004-04-23 | @ DET | 17 | L 3-17 | 6-11 | 4 | 22,008 | Jason Davis | Jeremy Bonderman | Jeremy Bonderman | Jason Davis | Esteban Yan | 86 | 112 | -26 |
| 2004-04-24 | @ DET | 18 | L 2-5 | 6-12 | 5 | 20,913 | Cliff Lee | Nate Robertson | Ugueth Urbina | Scott Stewart | | 88 | 117 | -29 |
| 2004-04-25 | @ DET | 19 | W 3-2 | 7-12 | 4 | 17,253 | Jake Westbrook | Jason Johnson | Jake Westbrook | Jason Johnson | | 91 | 119 | -28 |
| 2004-04-27 | @ CHA | 20 | W 11-7 | 8-12 | 4 | 14,572 | Jeff D'Amico | Jon Garland | Rafael Betancourt | Jon Adkins | | 102 | 126 | -24 |
| 2004-04-28 | @ CHA | 21 | L 8-9 | 8-13 | 4 | 12,189 | Jason Davis | Scott Schoeneweis | Michael Jackson | Rafael Betancourt | | 110 | 135 | -25 |
| 2004-04-30 | vs BAL | 22 | W 11-2 | 9-13 | 4 | 18,782 | Cliff Lee | Sidney Ponson | Cliff Lee | Sidney Ponson | | 121 | 137 | -16 |
| 2004-05-01 | vs BAL | 23 | W 3-2 | 10-13 | 4 | 17,275 | CC Sabathia | Erik Bedard | Chad Durbin | Mike DeJean | | 124 | 139 | -15 |
| 2004-05-03 | vs BOS | 24 | W 2-1 | 11-13 | 4 | 16,285 | Jake Westbrook | Curt Schilling | Jake Westbrook | Curt Schilling | Rafael Betancourt | 126 | 140 | -14 |
| 2004-05-04 | vs BOS | 25 | W 7-6 | 12-13 | 4 | 16,070 | Jason Davis | Derek Lowe | Jason Davis | Derek Lowe | Rafael Betancourt | 133 | 146 | -13 |
| 2004-05-05 | vs BOS | 26 | L 5-9 | 12-14 | 4 | 17,370 | Jeff D'Amico | Byung-Hyun Kim | Bronson Arroyo | Jeff D'Amico | | 138 | 155 | -17 |
| 2004-05-06 | vs BOS | 27 | L 2-5 | 12-15 | 4 | 26,825 | CC Sabathia | Pedro Martinez | Pedro Martinez | CC Sabathia | Keith Foulke | 140 | 160 | -20 |
| 2004-05-07 | @ BAL | 28 | L 2-3 | 12-16 | 4 | 34,324 | Cliff Lee | Erik Bedard | Jorge Julio | Chad Durbin | | 142 | 163 | -21 |
| 2004-05-08 | @ BAL | 29 | L 7-10 | 12-17 | 4 | 30,687 | Jake Westbrook | Kurt Ainsworth | John Parrish | Scott Stewart | Jorge Julio | 149 | 173 | -24 |
| 2004-05-09 | @ BAL | 30 | L 11-12 | 12-18 | 4 | 35,778 | Jason Davis | Eric DuBose | Rodrigo Lopez | David Riske | Jorge Julio | 160 | 185 | -25 |
| 2004-05-10 | @ BOS | 31 | W 10-6 | 13-18 | 4 | 35,257 | Jeff D'Amico | Byung-Hyun Kim | Chad Durbin | Byung-Hyun Kim | | 170 | 191 | -21 |
| 2004-05-11 | @ BOS | 32 | L 3-5 | 13-19 | 4 | 35,401 | CC Sabathia | Pedro Martinez | Alan Embree | Jose Jimenez | Keith Foulke | 173 | 196 | -23 |
| 2004-05-12 | @ BOS | 33 | W 6-4 | 14-19 | 4 | 35,371 | Cliff Lee | Tim Wakefield | Cliff Lee | Tim Wakefield | | 179 | 200 | -21 |
| 2004-05-14 | vs TBA | 34 | W 8-7 | 15-19 | 4 | 19,796 | Jason Davis | Paul Abbott | Rick White | Lance Carter | | 187 | 207 | -20 |
| 2004-05-15 | vs TBA | 35 | W 9-7 | 16-19 | 4 | 18,040 | Jake Westbrook | Victor Zambrano | Jake Westbrook | Victor Zambrano | | 196 | 214 | -18 |
| 2004-05-16 | vs TBA | 36 | W 10-0 | 17-19 | 4 | 19,499 | CC Sabathia | Doug Waechter | CC Sabathia | Doug Waechter | | 206 | 214 | -8 |
| 2004-05-17 | vs CHA | 37 | W 7-2 | 18-19 | 3 | 15,617 | Cliff Lee | Felix Diaz | Cliff Lee | Felix Diaz | | 213 | 216 | -3 |
| 2004-05-18 | vs CHA | 38 | L 2-4 | 18-20 | 4 | 15,298 | Chad Durbin | Jon Garland | Jon Garland | Chad Durbin | Billy Koch | 215 | 220 | -5 |
| 2004-05-19 | vs CHA | 39 | L 3-15 | 18-21 | 4 | 17,205 | Jason Davis | Scott Schoeneweis | Scott Schoeneweis | Jason Davis | | 218 | 235 | -17 |
| 2004-05-21 | @ TBA | 40 | L 3-5 | 18-22 | 4 | 10,213 | CC Sabathia | Paul Abbott | Trever Miller | CC Sabathia | Danys Baez | 221 | 240 | -19 |
| 2004-05-22 | @ TBA | 41 | L 3-6 | 18-23 | 4 | 12,008 | Jake Westbrook | Doug Waechter | Doug Waechter | Jake Westbrook | Jorge Sosa | 224 | 246 | -22 |
| 2004-05-23 | @ TBA | 42 | L 4-5 | 18-24 | 4 | 10,555 | Cliff Lee | Mark Hendrickson | Travis Harper | David Riske | | 228 | 251 | -23 |
| 2004-05-25 | vs SEA | 43 | L 4-5 | 18-25 | 4 | 15,349 | Jason Davis | Ryan Franklin | Mike Myers | Jose Jimenez | Eddie Guardado | 232 | 256 | -24 |
| 2004-05-26 | vs SEA | 44 | L 3-7 | 18-26 | 4 | 16,007 | CC Sabathia | Jamie Moyer | Jamie Moyer | CC Sabathia | Eddie Guardado | 235 | 263 | -28 |
| 2004-05-27 | vs SEA | 45 | W 9-5 | 19-26 | 4 | 17,272 | Jake Westbrook | Gil Meche | Jake Westbrook | Gil Meche | | 244 | 268 | -24 |
| 2004-05-28 | vs OAK | 46 | W 1-0 | 20-26 | 4 | 19,257 | Cliff Lee | Barry Zito | Jose Jimenez | Jim Mecir | | 245 | 268 | -23 |
| 2004-05-29 | vs OAK | 47 | W 8-6 | 21-26 | 4 | 26,441 | Joey Dawley | Rich Harden | David Riske | Arthur Rhodes | Jose Jimenez | 253 | 274 | -21 |
| 2004-05-30 | vs OAK | 48 | W 4-3 | 22-26 | 3 | 24,005 | Jason Davis | Tim Hudson | Rick White | Arthur Rhodes | | 257 | 277 | -20 |
| 2004-06-01 | vs TEX | 49 | L 5-6 | 22-27 | 4 | 17,136 | CC Sabathia | Ryan Drese | Erasmo Ramirez | Rick White | Francisco Cordero | 262 | 283 | -21 |
| 2004-06-02 | vs TEX | 50 | L 3-5 | 22-28 | 4 | 18,098 | Jake Westbrook | R.A. Dickey | Carlos Almanzar | Rafael Betancourt | Francisco Cordero | 265 | 288 | -23 |
| 2004-06-03 | @ ANA | 51 | L 2-5 | 22-29 | 4 | 39,353 | Cliff Lee | Kelvim Escobar | Kelvim Escobar | Cliff Lee | | 267 | 293 | -26 |
| 2004-06-04 | @ ANA | 52 | W 9-6 | 23-29 | 4 | 43,590 | Jason Davis | Aaron Sele | David Riske | Francisco Rodriguez | Jose Jimenez | 276 | 299 | -23 |
| 2004-06-05 | @ ANA | 53 | W 3-2 | 24-29 | 4 | 43,514 | Joey Dawley | John Lackey | Rick White | John Lackey | Jose Jimenez | 279 | 301 | -22 |
| 2004-06-06 | @ ANA | 54 | W 7-0 | 25-29 | 3 | 43,337 | CC Sabathia | Bartolo Colon | CC Sabathia | Bartolo Colon | | 286 | 301 | -15 |
| 2004-06-08 | vs FLO | 55 | L 5-7 | 25-30 | 3 | 21,252 | Cliff Lee | Dontrelle Willis | Nate Bump | Jose Jimenez | Armando Benitez | 291 | 308 | -17 |
| 2004-06-09 | vs FLO | 56 | W 8-1 | 26-30 | 3 | 17,072 | Jake Westbrook | A.J. Burnett | Jake Westbrook | A.J. Burnett | | 299 | 309 | -10 |
| 2004-06-10 | vs FLO | 57 | L 1-4 | 26-31 | 4 | 19,113 | Jason Davis | Carl Pavano | Carl Pavano | Jason Davis | Armando Benitez | 300 | 313 | -13 |
| 2004-06-11 | vs CIN | 58 | W 6-5 | 27-31 | 4 | 27,308 | CC Sabathia | Paul Wilson | David Riske | Phil Norton | | 306 | 318 | -12 |
| 2004-06-12 | vs CIN | 59 | W 8-7 | 28-31 | 4 | 42,101 | Scott Elarton | Todd Van Poppel | Rafael Betancourt | Phil Norton | Jose Jimenez | 314 | 325 | -11 |
| 2004-06-13 | vs CIN | 60 | W 10-8 | 29-31 | 3 | 31,235 | Cliff Lee | Cory Lidle | Matt Miller | Brian Reith | Jose Jimenez | 324 | 333 | -9 |
| 2004-06-14 | vs BAL | 61 | W 14-0 | 30-31 | 3 | 19,340 | Jake Westbrook | Eric DuBose | Jake Westbrook | Eric DuBose | | 338 | 333 | 5 |
| 2004-06-15 | @ NYN | 62 | L 2-7 | 30-32 | 3 | 22,783 | Jason Davis | Steve Trachsel | Steve Trachsel | Jason Davis | | 340 | 340 | 0 |
| 2004-06-16 | @ NYN | 63 | W 9-1 | 31-32 | 3 | 29,512 | CC Sabathia | Matt Ginter | CC Sabathia | Matt Ginter | | 349 | 341 | 8 |
| 2004-06-17 | @ NYN | 64 | L 2-6 | 31-33 | 3 | 17,675 | Scott Elarton | Jae Weong Seo | Ricky Bottalico | Rick White | | 351 | 347 | 4 |
| 2004-06-18 | @ ATL | 65 | W 4-2 | 32-33 | 3 | 28,000 | Cliff Lee | Mike Hampton | Cliff Lee | Mike Hampton | Jose Jimenez | 355 | 349 | 6 |
| 2004-06-19 | @ ATL | 66 | L 0-4 | 32-34 | 3 | 41,987 | Jake Westbrook | Paul Byrd | Paul Byrd | Jake Westbrook | John Smoltz | 355 | 353 | 2 |
| 2004-06-20 | @ ATL | 67 | W 5-2 | 33-34 | 3 | 31,000 | Jason Davis | Russ Ortiz | Jason Davis | Russ Ortiz | Jose Jimenez | 360 | 355 | 5 |
| 2004-06-21 | @ CHA | 68 | W 5-1 | 34-34 | 3 | 29,722 | CC Sabathia | Scott Schoeneweis | CC Sabathia | Scott Schoeneweis | | 365 | 356 | 9 |
| 2004-06-22 | @ CHA | 69 | L 9-11 | 34-35 | 3 | 27,922 | Scott Elarton | Esteban Loaiza | Shingo Takatsu | Jose Jimenez | | 374 | 367 | 7 |
| 2004-06-23 | @ CHA | 70 | W 9-5 | 35-35 | 3 | 21,654 | Cliff Lee | Mark Buehrle | Cliff Lee | Mark Buehrle | | 383 | 372 | 11 |
| 2004-06-24 | @ CHA | 71 | L 1-7 | 35-36 | 3 | 20,744 | Jake Westbrook | Jon Rauch | Jon Rauch | Jake Westbrook | | 384 | 379 | 5 |
| 2004-06-25 | vs COL | 72 | L 8-10 | 35-37 | 3 | 22,642 | Jason Davis | Jeff Fassero | Steve Reed | Jose Jimenez | Shawn Chacon | 392 | 389 | 3 |
| 2004-06-26 | vs COL | 73 | W 4-3 | 36-37 | 3 | 29,124 | CC Sabathia | Joe Kennedy | Jeriome Robertson | Steve Reed | | 396 | 392 | 4 |
| 2004-06-27 | vs COL | 74 | W 5-3 | 37-37 | 3 | 27,252 | Scott Elarton | Jason Jennings | Matt Miller | Jason Jennings | Jose Jimenez | 401 | 395 | 6 |
| 2004-06-29 | @ DET | 75 | L 7-9 | 37-38 | 3 | 30,457 | Jake Westbrook | Gary Knotts | Craig Dingman | Jose Jimenez | | 408 | 404 | 4 |
| 2004-06-30 | @ DET | 76 | L 5-12 | 37-39 | 3 | 27,665 | Jason Davis | Nate Robertson | Nate Robertson | Jason Davis | | 413 | 416 | -3 |
| 2004-07-01 | @ DET | 77 | W 7-6 | 38-39 | 3 | 25,159 | Cliff Lee | Jason Johnson | David Riske | Ugueth Urbina | Rick White | 420 | 422 | -2 |
| 2004-07-02 | @ CIN | 78 | W 15-2 | 39-39 | 3 | 36,156 | Kazuhito Tadano | Jesus Sanchez | Kazuhito Tadano | Jesus Sanchez | | 435 | 424 | 11 |
| 2004-07-03 | @ CIN | 79 | L 2-4 | 39-40 | 3 | 38,708 | Scott Elarton | Paul Wilson | Paul Wilson | Scott Elarton | Danny Graves | 437 | 428 | 9 |
| 2004-07-04 | @ CIN | 80 | L 4-5 | 39-41 | 3 | 30,375 | Jake Westbrook | Aaron Harang | Todd Jones | Rick White | | 441 | 433 | 8 |
| 2004-07-05 | vs TEX | 81 | L 5-8 | 39-42 | 3 | 25,363 | CC Sabathia | Kenny Rogers | Kenny Rogers | CC Sabathia | Francisco Cordero | 446 | 441 | 5 |
| 2004-07-06 | vs TEX | 82 | W 4-1 | 40-42 | 3 | 16,796 | Cliff Lee | Nick Bierbrodt | Cliff Lee | Nick Bierbrodt | David Riske | 450 | 442 | 8 |
| 2004-07-07 | vs TEX | 83 | L 8-9 | 40-43 | 3 | 18,499 | Jason Davis | Ryan Drese | Ron Mahay | Jeriome Robertson | Francisco Cordero | 458 | 451 | 7 |
| 2004-07-08 | vs TEX | 84 | L 0-10 | 40-44 | 3 | 24,914 | Scott Elarton | Ricardo Rodriguez | Ricardo Rodriguez | Scott Elarton | | 458 | 461 | -3 |
| 2004-07-09 | vs OAK | 85 | W 5-4 | 41-44 | 3 | 24,325 | Jake Westbrook | Kirk Saarloos | Bob Howry | Octavio Dotel | | 463 | 465 | -2 |
| 2004-07-10 | vs OAK | 86 | L 7-16 | 41-45 | 3 | 28,448 | CC Sabathia | Mark Mulder | Mark Mulder | Rick White | | 470 | 481 | -11 |
| 2004-07-11 | vs OAK | 87 | W 4-1 | 42-45 | 3 | 24,622 | Cliff Lee | Barry Zito | Cliff Lee | Barry Zito | David Riske | 474 | 482 | -8 |
| 2004-07-15 | @ SEA | 88 | L 1-2 | 42-46 | 3 | 32,896 | Jake Westbrook | Joel Pineiro | Joel Pineiro | Jake Westbrook | Eddie Guardado | 475 | 484 | -9 |
| 2004-07-16 | @ SEA | 89 | W 18-6 | 43-46 | 3 | 32,578 | Cliff Lee | Travis Blackley | Cliff Lee | Travis Blackley | | 493 | 490 | 3 |
| 2004-07-17 | @ SEA | 90 | W 6-5 | 44-46 | 3 | 36,154 | CC Sabathia | Ryan Franklin | CC Sabathia | Ryan Franklin | David Riske | 499 | 495 | 4 |
| 2004-07-18 | @ SEA | 91 | L 5-7 | 44-47 | 3 | 37,363 | Scott Elarton | Jamie Moyer | Shigetoshi Hasegawa | Matt Miller | Eddie Guardado | 504 | 502 | 2 |
| 2004-07-19 | @ ANA | 92 | W 8-5 | 45-47 | 3 | 42,986 | Kazuhito Tadano | Aaron Sele | David Riske | Troy Percival | Matt Miller | 512 | 507 | 5 |
| 2004-07-20 | @ ANA | 93 | W 14-5 | 46-47 | 3 | 40,000 | Jake Westbrook | Jarrod Washburn | Jake Westbrook | Jarrod Washburn | | 526 | 512 | 14 |
| 2004-07-21 | vs CHA | 94 | L 0-14 | 46-48 | 3 | 21,922 | Cliff Lee | Mark Buehrle | Mark Buehrle | Cliff Lee | | 526 | 526 | 0 |
| 2004-07-22 | vs CHA | 95 | L 0-3 | 46-49 | 3 | 23,168 | CC Sabathia | Freddy Garcia | Freddy Garcia | CC Sabathia | Shingo Takatsu | 526 | 529 | -3 |
| 2004-07-23 | vs KCA | 96 | W 3-2 | 47-49 | 3 | 26,504 | Scott Elarton | Mike Wood | Rick White | Nate Field | | 529 | 531 | -2 |
| 2004-07-24 | vs KCA | 97 | W 10-2 | 49-49 | 3 | 18,873 | Chad Durbin | Chris George | Chad Durbin | Chris George | | 539 | 533 | 6 |
| 2004-07-24 | vs KCA | 98 | W 4-3 | 49-49 | 3 | 27,865 | Kazuhito Tadano | Brian Anderson | Matt Miller | Scott Sullivan | | 543 | 536 | 7 |
| 2004-07-25 | vs KCA | 99 | W 5-1 | 50-49 | 3 | 23,540 | Jake Westbrook | Zack Greinke | Jake Westbrook | Zack Greinke | | 548 | 537 | 11 |
| 2004-07-26 | vs DET | 100 | L 4-13 | 50-50 | 3 | 18,359 | Cliff Lee | Mike Maroth | Mike Maroth | Cliff Lee | | 552 | 550 | 2 |
| 2004-07-27 | vs DET | 101 | W 10-6 | 51-50 | 3 | 19,090 | CC Sabathia | Gary Knotts | CC Sabathia | Gary Knotts | | 562 | 556 | 6 |
| 2004-07-28 | vs DET | 102 | W 5-4 | 52-50 | 3 | 23,213 | Scott Elarton | Nate Robertson | Scott Elarton | Jamie Walker | Bob Wickman | 567 | 560 | 7 |
| 2004-07-30 | @ KCA | 103 | W 7-6 | 53-50 | 3 | 32,079 | Jake Westbrook | Brian Anderson | Rafael Betancourt | Scott Sullivan | | 574 | 566 | 8 |
| 2004-07-31 | @ KCA | 104 | L 3-10 | 53-51 | 3 | 27,689 | Kazuhito Tadano | Zack Greinke | Zack Greinke | Kazuhito Tadano | | 577 | 576 | 1 |
| 2004-08-01 | @ KCA | 105 | L 7-8 | 53-52 | 3 | 15,641 | CC Sabathia | Darrell May | Darrell May | CC Sabathia | Shawn Camp | 584 | 584 | 0 |
| 2004-08-02 | @ TOR | 106 | L 1-6 | 53-53 | 3 | 17,549 | Cliff Lee | Ted Lilly | Ted Lilly | Cliff Lee | | 585 | 590 | -5 |
| 2004-08-03 | @ TOR | 107 | L 6-7 | 53-54 | 3 | 15,025 | Scott Elarton | Miguel Batista | Justin Speier | Rafael Betancourt | Jason Frasor | 591 | 597 | -6 |
| 2004-08-04 | @ TOR | 108 | W 14-5 | 54-54 | 3 | 15,675 | Jake Westbrook | Josh Towers | Jake Westbrook | Josh Towers | | 605 | 602 | 3 |
| 2004-08-05 | @ TOR | 109 | W 6-3 | 55-54 | 3 | 30,037 | Chad Durbin | David Bush | Rafael Betancourt | Kerry Ligtenberg | Bob Wickman | 611 | 605 | 6 |
| 2004-08-06 | @ CHA | 110 | W 3-2 | 56-54 | 3 | 23,811 | CC Sabathia | Mark Buehrle | CC Sabathia | Mark Buehrle | Bob Wickman | 614 | 607 | 7 |
| 2004-08-07 | @ CHA | 111 | W 6-5 | 57-54 | 2 | 32,790 | Cliff Lee | Freddy Garcia | Matt Miller | Shingo Takatsu | Bob Wickman | 620 | 612 | 8 |
| 2004-08-08 | @ CHA | 112 | L 2-3 | 57-55 | 3 | 25,897 | Scott Elarton | Jose Contreras | Shingo Takatsu | Rafael Betancourt | | 622 | 615 | 7 |
| 2004-08-09 | @ CHA | 113 | W 13-11 | 58-55 | 2 | 31,116 | Jake Westbrook | Felix Diaz | Jake Westbrook | Felix Diaz | | 635 | 626 | 9 |
| 2004-08-10 | vs TOR | 114 | W 2-0 | 59-55 | 2 | 19,942 | Chad Durbin | David Bush | Chad Durbin | David Bush | Bob Wickman | 637 | 626 | 11 |
| 2004-08-11 | vs TOR | 115 | W 3-2 | 60-55 | 2 | 23,696 | CC Sabathia | Justin Miller | CC Sabathia | Kevin Frederick | Bob Wickman | 640 | 628 | 12 |
| 2004-08-12 | vs TOR | 116 | W 6-2 | 61-55 | 2 | 22,734 | Cliff Lee | Ted Lilly | David Riske | Kerry Ligtenberg | | 646 | 630 | 16 |
| 2004-08-13 | vs MIN | 117 | W 8-2 | 62-55 | 2 | 30,101 | Scott Elarton | Carlos Silva | Scott Elarton | Carlos Silva | | 654 | 632 | 22 |
| 2004-08-14 | vs MIN | 118 | W 7-1 | 63-55 | 2 | 40,942 | Jake Westbrook | Kyle Lohse | Jake Westbrook | Kyle Lohse | | 661 | 633 | 28 |
| 2004-08-15 | vs MIN | 119 | L 2-4 | 63-56 | 2 | 38,019 | Chad Durbin | Terry Mulholland | Juan Rincon | Rick White | Joe Nathan | 663 | 637 | 26 |
| 2004-08-16 | @ TEX | 120 | L 2-5 | 63-57 | 2 | 23,551 | CC Sabathia | Mickey Callaway | Erasmo Ramirez | CC Sabathia | Francisco Cordero | 665 | 642 | 23 |
| 2004-08-17 | @ TEX | 121 | L 4-16 | 63-58 | 2 | 24,864 | Cliff Lee | Scott Erickson | Scott Erickson | Cliff Lee | Doug Brocail | 669 | 658 | 11 |
| 2004-08-18 | @ TEX | 122 | L 2-5 | 63-59 | 2 | 31,572 | Scott Elarton | Kenny Rogers | Kenny Rogers | Scott Elarton | Francisco Cordero | 671 | 663 | 8 |
| 2004-08-20 | @ MIN | 123 | L 1-5 | 63-60 | 2 | 25,157 | Jake Westbrook | Kyle Lohse | Kyle Lohse | Jake Westbrook | | 672 | 668 | 4 |
| 2004-08-21 | @ MIN | 124 | L 1-8 | 63-61 | 2 | 27,945 | Chad Durbin | Terry Mulholland | Terry Mulholland | Chad Durbin | | 673 | 676 | -3 |
| 2004-08-22 | @ MIN | 125 | L 3-7 | 63-62 | 2 | 28,587 | CC Sabathia | Brad Radke | Brad Radke | CC Sabathia | | 676 | 683 | -7 |
| 2004-08-23 | vs NYA | 126 | L 4-6 | 63-63 | 2 | 33,172 | Cliff Lee | Mike Mussina | Tom Gordon | Bob Wickman | Mariano Rivera | 680 | 689 | -9 |
| 2004-08-24 | vs NYA | 127 | L 4-5 | 63-64 | 2 | 31,729 | Scott Elarton | Javier Vazquez | Tom Gordon | Bob Wickman | Mariano Rivera | 684 | 694 | -10 |
| 2004-08-25 | vs NYA | 128 | W 4-3 | 64-64 | 2 | 30,605 | Jake Westbrook | Orlando Hernandez | David Riske | Tom Gordon | Rafael Betancourt | 688 | 697 | -9 |
| 2004-08-26 | vs CHA | 129 | L 9-14 | 64-65 | 2 | 30,049 | Chad Durbin | Josh Stewart | Neal Cotts | Chad Durbin | | 697 | 711 | -14 |
| 2004-08-27 | vs CHA | 130 | W 6-3 | 65-65 | 2 | 30,527 | CC Sabathia | Jason Grilli | CC Sabathia | Jason Grilli | Bob Wickman | 703 | 714 | -11 |
| 2004-08-28 | vs CHA | 131 | L 3-5 | 65-66 | 2 | 37,374 | Cliff Lee | Jose Contreras | Jose Contreras | Cliff Lee | Shingo Takatsu | 706 | 719 | -13 |
| 2004-08-29 | vs CHA | 132 | W 9-0 | 66-66 | 2 | 32,834 | Scott Elarton | Jon Garland | Scott Elarton | Jon Garland | | 715 | 719 | -4 |
| 2004-08-31 | @ NYA | 133 | W 22-0 | 67-66 | 2 | 51,777 | Jake Westbrook | Javier Vazquez | Jake Westbrook | Javier Vazquez | | 737 | 719 | 18 |
| 2004-09-01 | @ NYA | 134 | L 3-5 | 67-67 | 2 | 41,448 | CC Sabathia | Orlando Hernandez | Orlando Hernandez | CC Sabathia | Mariano Rivera | 740 | 724 | 16 |
| 2004-09-02 | @ NYA | 135 | L 1-9 | 67-68 | 2 | 37,963 | Cliff Lee | Jon Lieber | Jon Lieber | Cliff Lee | | 741 | 733 | 8 |
| 2004-09-03 | vs ANA | 136 | L 5-10 | 67-69 | 3 | 20,994 | Scott Elarton | Kelvim Escobar | Kelvim Escobar | Scott Elarton | | 746 | 743 | 3 |
| 2004-09-04 | vs ANA | 137 | L 1-6 | 67-70 | 3 | 23,786 | Jason Davis | Jarrod Washburn | Jarrod Washburn | Jason Davis | | 747 | 749 | -2 |
| 2004-09-05 | vs ANA | 138 | L 1-2 | 67-71 | 3 | 26,208 | Jake Westbrook | John Lackey | John Lackey | Jake Westbrook | Francisco Rodriguez | 748 | 751 | -3 |
| 2004-09-06 | @ SEA | 139 | W 5-0 | 68-71 | 3 | 33,084 | CC Sabathia | Gil Meche | CC Sabathia | Gil Meche | | 753 | 751 | 2 |
| 2004-09-08 | @ SEA | 140 | W 9-5 | 69-71 | 3 | 28,764 | Cliff Lee | Cha-Seung Baek | Cliff Lee | Cha-Seung Baek | | 762 | 756 | 6 |
| 2004-09-10 | @ OAK | 141 | W 4-3 | 70-71 | 3 | 24,154 | Scott Elarton | Mark Mulder | Rick White | Justin Duchscherer | Bob Wickman | 766 | 759 | 7 |
| 2004-09-11 | @ OAK | 142 | L 4-5 | 70-72 | 3 | 30,436 | CC Sabathia | Rich Harden | Ricardo Rincon | Bob Howry | Octavio Dotel | 770 | 764 | 6 |
| 2004-09-12 | @ OAK | 143 | L 0-1 | 70-73 | 3 | 29,107 | Jake Westbrook | Barry Zito | Barry Zito | Jake Westbrook | Octavio Dotel | 770 | 765 | 5 |
| 2004-09-14 | vs DET | 144 | L 3-11 | 70-74 | 3 | 16,489 | Kyle Denney | Jeremy Bonderman | Jeremy Bonderman | Kyle Denney | | 773 | 776 | -3 |
| 2004-09-15 | vs DET | 145 | W 5-3 | 71-74 | 3 | 15,411 | Scott Elarton | Mike Maroth | Bob Howry | Esteban Yan | Bob Wickman | 778 | 779 | -1 |
| 2004-09-16 | vs DET | 146 | L 4-6 | 71-75 | 3 | 15,943 | CC Sabathia | Gary Knotts | Jamie Walker | CC Sabathia | Esteban Yan | 782 | 785 | -3 |
| 2004-09-17 | vs KCA | 147 | L 4-6 | 71-76 | 3 | 14,347 | Jake Westbrook | Mike Wood | Mike Wood | Jake Westbrook | Jeremy Affeldt | 786 | 791 | -5 |
| 2004-09-18 | vs KCA | 148 | L 1-7 | 71-77 | 3 | 17,848 | Cliff Lee | Jimmy Gobble | Jimmy Gobble | Cliff Lee | | 787 | 798 | -11 |
| 2004-09-19 | vs KCA | 149 | W 8-3 | 72-77 | 3 | 16,745 | Kyle Denney | Denny Bautista | Kyle Denney | Denny Bautista | | 795 | 801 | -6 |
| 2004-09-20 | @ DET | 150 | L 1-3 | 72-78 | 3 | 13,820 | Scott Elarton | Mike Maroth | Mike Maroth | Scott Elarton | Esteban Yan | 796 | 804 | -8 |
| 2004-09-21 | @ DET | 151 | W 8-7 | 73-78 | 3 | 11,351 | Francisco Cruceta | Gary Knotts | Bob Howry | Esteban Yan | Bob Wickman | 804 | 811 | -7 |
| 2004-09-22 | @ DET | 152 | W 7-6 | 74-78 | 3 | 16,360 | Jake Westbrook | Nate Robertson | Jake Westbrook | Wil Ledezma | | 811 | 817 | -6 |
| 2004-09-23 | vs MIN | 153 | W 9-7 | 75-78 | 3 | 18,053 | Cliff Lee | J.D. Durbin | Cliff Lee | J.D. Durbin | Rafael Betancourt | 820 | 824 | -4 |
| 2004-09-24 | vs MIN | 154 | L 2-8 | 75-79 | 3 | 16,253 | Kyle Denney | Johan Santana | Johan Santana | Kyle Denney | | 822 | 832 | -10 |
| 2004-09-25 | vs MIN | 155 | W 5-3 | 76-79 | 3 | 23,541 | Scott Elarton | Brad Radke | Bob Howry | J.C. Romero | Bob Wickman | 827 | 835 | -8 |
| 2004-09-26 | vs MIN | 156 | L 2-6 | 76-80 | 3 | 22,091 | Francisco Cruceta | Carlos Silva | Carlos Silva | Francisco Cruceta | | 829 | 841 | -12 |
| 2004-09-27 | @ KCA | 157 | W 6-1 | 77-80 | 3 | 11,544 | Jake Westbrook | Zack Greinke | Jake Westbrook | Jaime Cerda | | 835 | 842 | -7 |
| 2004-09-28 | @ KCA | 158 | W 5-1 | 78-80 | 3 | 11,847 | Cliff Lee | Darrell May | Cliff Lee | Darrell May | | 840 | 843 | -3 |
| 2004-09-29 | @ KCA | 159 | W 5-2 | 79-80 | 3 | 11,193 | Kyle Denney | Mike Wood | Cliff Bartosh | Mike Wood | Bob Wickman | 845 | 845 | 0 |
| 2004-10-01 | @ MIN | 160 | L 3-4 | 79-81 | 3 | 25,322 | Scott Elarton | Terry Mulholland | Jesse Crain | Bob Howry | Joe Nathan | 848 | 849 | -1 |
| 2004-10-02 | @ MIN | 161 | L 5-6 | 79-82 | 3 | 32,268 | Jake Westbrook | Carlos Silva | Kyle Lohse | David Riske | | 853 | 855 | -2 |
| 2004-10-03 | @ MIN | 162 | W 5-2 | 80-82 | 3 | 28,624 | Cliff Lee | Kyle Lohse | Cliff Lee | Kyle Lohse | Bob Wickman | 858 | 857 | 1 |