| 2004-04-04 | @ BAL | 1 | L 2-7 | 0-1 | 4 | 47,683 | Pedro Martinez | Sidney Ponson | Sidney Ponson | Pedro Martinez | B.J. Ryan | 2 | 7 | -5 |
| 2004-04-06 | @ BAL | 2 | W 4-1 | 1-1 | 3 | 35,355 | Curt Schilling | Eric DuBose | Curt Schilling | Eric DuBose | Keith Foulke | 6 | 8 | -2 |
| 2004-04-07 | @ BAL | 3 | W 10-3 | 2-1 | 1 | 28,373 | Derek Lowe | Kurt Ainsworth | Derek Lowe | Kurt Ainsworth | | 16 | 11 | 5 |
| 2004-04-08 | @ BAL | 4 | L 2-3 | 2-2 | 3 | 31,121 | Tim Wakefield | Matt Riley | Rodrigo Lopez | Bobby Jones | | 18 | 14 | 4 |
| 2004-04-09 | vs TOR | 5 | L 5-10 | 2-3 | 4 | 34,337 | Bronson Arroyo | Ted Lilly | Justin Speier | Mike Timlin | | 23 | 24 | -1 |
| 2004-04-10 | vs TOR | 6 | W 4-1 | 3-3 | 2 | 35,305 | Pedro Martinez | Roy Halladay | Pedro Martinez | Roy Halladay | Keith Foulke | 27 | 25 | 2 |
| 2004-04-11 | vs TOR | 7 | W 6-4 | 4-3 | 1 | 34,286 | Curt Schilling | Miguel Batista | Mark Malaska | Aquilino Lopez | | 33 | 29 | 4 |
| 2004-04-15 | vs BAL | 8 | L 7-12 | 4-4 | 3 | 35,271 | Pedro Martinez | Sidney Ponson | Buddy Groom | Bronson Arroyo | | 40 | 41 | -1 |
| 2004-04-16 | vs NYA | 9 | W 6-2 | 5-4 | 2 | 35,163 | Tim Wakefield | Javier Vazquez | Tim Wakefield | Javier Vazquez | | 46 | 43 | 3 |
| 2004-04-17 | vs NYA | 10 | W 5-2 | 6-4 | 2 | 35,023 | Curt Schilling | Mike Mussina | Curt Schilling | Mike Mussina | | 51 | 45 | 6 |
| 2004-04-18 | vs NYA | 11 | L 3-7 | 6-5 | 2 | 35,011 | Derek Lowe | Jose Contreras | Paul Quantrill | Derek Lowe | | 54 | 52 | 2 |
| 2004-04-19 | vs NYA | 12 | W 5-4 | 7-5 | 2 | 35,027 | Bronson Arroyo | Kevin Brown | Mike Timlin | Tom Gordon | Keith Foulke | 59 | 56 | 3 |
| 2004-04-20 | @ TOR | 13 | W 4-2 | 8-5 | 2 | 26,010 | Pedro Martinez | Roy Halladay | Pedro Martinez | Roy Halladay | Keith Foulke | 63 | 58 | 5 |
| 2004-04-21 | @ TOR | 14 | W 4-2 | 9-5 | 1 | 16,163 | Tim Wakefield | Ted Lilly | Tim Wakefield | Ted Lilly | Keith Foulke | 67 | 60 | 7 |
| 2004-04-22 | @ TOR | 15 | L 3-7 | 9-6 | 2 | 16,480 | Curt Schilling | Miguel Batista | Terry Adams | Curt Schilling | | 70 | 67 | 3 |
| 2004-04-23 | @ NYA | 16 | W 11-2 | 10-6 | 2 | 55,001 | Derek Lowe | Jose Contreras | Derek Lowe | Jose Contreras | | 81 | 69 | 12 |
| 2004-04-24 | @ NYA | 17 | W 3-2 | 11-6 | 1 | 55,195 | Bronson Arroyo | Kevin Brown | Keith Foulke | Paul Quantrill | Mike Timlin | 84 | 71 | 13 |
| 2004-04-25 | @ NYA | 18 | W 2-0 | 12-6 | 1 | 55,338 | Pedro Martinez | Javier Vazquez | Pedro Martinez | Javier Vazquez | Scott Williamson | 86 | 71 | 15 |
| 2004-04-28 | vs TBA | 19 | W 6-0 | 13-6 | 1 | 35,120 | Curt Schilling | Paul Abbott | Curt Schilling | Paul Abbott | | 92 | 71 | 21 |
| 2004-04-29 | vs TBA | 20 | W 4-0 | 15-6 | 1 | 35,614 | Byung-Hyun Kim | Victor Zambrano | Byung-Hyun Kim | Victor Zambrano | | 96 | 71 | 25 |
| 2004-04-29 | vs TBA | 21 | W 7-3 | 15-6 | 1 | 35,441 | Derek Lowe | Damian Moss | Derek Lowe | Damian Moss | | 103 | 74 | 29 |
| 2004-05-01 | @ TEX | 22 | L 3-4 | 15-8 | 1 | 0 | Bronson Arroyo | Ryan Drese | Erasmo Ramirez | Mark Malaska | Francisco Cordero | 106 | 78 | 28 |
| 2004-05-01 | @ TEX | 23 | L 5-8 | 15-8 | 1 | 44,598 | Pedro Martinez | Joaquin Benoit | Joaquin Benoit | Pedro Martinez | Francisco Cordero | 111 | 86 | 25 |
| 2004-05-02 | @ TEX | 24 | L 1-4 | 15-9 | 1 | 31,538 | Tim Wakefield | R.A. Dickey | R.A. Dickey | Tim Wakefield | Francisco Cordero | 112 | 90 | 22 |
| 2004-05-03 | @ CLE | 25 | L 1-2 | 15-10 | 1 | 16,285 | Curt Schilling | Jake Westbrook | Jake Westbrook | Curt Schilling | Rafael Betancourt | 113 | 92 | 21 |
| 2004-05-04 | @ CLE | 26 | L 6-7 | 15-11 | 1 | 16,070 | Derek Lowe | Jason Davis | Jason Davis | Derek Lowe | Rafael Betancourt | 119 | 99 | 20 |
| 2004-05-05 | @ CLE | 27 | W 9-5 | 16-11 | 1 | 17,370 | Byung-Hyun Kim | Jeff D'Amico | Bronson Arroyo | Jeff D'Amico | | 128 | 104 | 24 |
| 2004-05-06 | @ CLE | 28 | W 5-2 | 17-11 | 1 | 26,825 | Pedro Martinez | CC Sabathia | Pedro Martinez | CC Sabathia | Keith Foulke | 133 | 106 | 27 |
| 2004-05-07 | vs KCA | 29 | W 7-6 | 18-11 | 1 | 35,280 | Tim Wakefield | Jeremy Affeldt | Mike Timlin | Mike MacDougal | | 140 | 112 | 28 |
| 2004-05-08 | vs KCA | 30 | W 9-1 | 19-11 | 1 | 34,929 | Curt Schilling | Jimmy Gobble | Curt Schilling | Jimmy Gobble | | 149 | 113 | 36 |
| 2004-05-09 | vs KCA | 31 | L 4-8 | 19-12 | 1 | 34,589 | Derek Lowe | Darrell May | Darrell May | Derek Lowe | | 153 | 121 | 32 |
| 2004-05-10 | vs CLE | 32 | L 6-10 | 19-13 | 1 | 35,257 | Byung-Hyun Kim | Jeff D'Amico | Chad Durbin | Byung-Hyun Kim | | 159 | 131 | 28 |
| 2004-05-11 | vs CLE | 33 | W 5-3 | 20-13 | 1 | 35,401 | Pedro Martinez | CC Sabathia | Alan Embree | Jose Jimenez | Keith Foulke | 164 | 134 | 30 |
| 2004-05-12 | vs CLE | 34 | L 4-6 | 20-14 | 1 | 35,371 | Tim Wakefield | Cliff Lee | Cliff Lee | Tim Wakefield | | 168 | 140 | 28 |
| 2004-05-13 | @ TOR | 35 | L 6-12 | 20-15 | 2 | 20,876 | Curt Schilling | Miguel Batista | Miguel Batista | Curt Schilling | | 174 | 152 | 22 |
| 2004-05-14 | @ TOR | 36 | W 9-3 | 21-15 | 2 | 20,948 | Derek Lowe | Justin Miller | Alan Embree | Kerry Ligtenberg | | 183 | 155 | 28 |
| 2004-05-15 | @ TOR | 37 | W 4-0 | 22-15 | 1 | 36,841 | Bronson Arroyo | Pat Hentgen | Bronson Arroyo | Pat Hentgen | | 187 | 155 | 32 |
| 2004-05-16 | @ TOR | 38 | L 1-3 | 22-16 | 2 | 31,618 | Pedro Martinez | Roy Halladay | Roy Halladay | Pedro Martinez | Terry Adams | 188 | 158 | 30 |
| 2004-05-18 | @ TBA | 39 | W 7-3 | 23-16 | 1 | 12,836 | Tim Wakefield | Mark Hendrickson | Tim Wakefield | Mark Hendrickson | | 195 | 161 | 34 |
| 2004-05-19 | @ TBA | 40 | W 4-1 | 24-16 | 1 | 13,960 | Curt Schilling | Rob Bell | Curt Schilling | Rob Bell | Keith Foulke | 199 | 162 | 37 |
| 2004-05-20 | @ TBA | 41 | L 6-9 | 24-17 | 2 | 12,401 | Derek Lowe | Victor Zambrano | Jorge Sosa | Derek Lowe | Danys Baez | 205 | 171 | 34 |
| 2004-05-21 | vs TOR | 42 | W 11-5 | 25-17 | 1 | 35,287 | Bronson Arroyo | Roy Halladay | Mike Timlin | Micheal Nakamura | | 216 | 176 | 40 |
| 2004-05-22 | vs TOR | 43 | W 5-2 | 26-17 | 1 | 35,196 | Pedro Martinez | Ted Lilly | Anastacio Martinez | Kerry Ligtenberg | Keith Foulke | 221 | 178 | 43 |
| 2004-05-23 | vs TOR | 44 | W 7-2 | 27-17 | 1 | 35,239 | Tim Wakefield | Miguel Batista | Tim Wakefield | Miguel Batista | | 228 | 180 | 48 |
| 2004-05-25 | vs OAK | 45 | W 12-2 | 28-17 | 1 | 35,236 | Curt Schilling | Tim Hudson | Curt Schilling | Tim Hudson | | 240 | 182 | 58 |
| 2004-05-26 | vs OAK | 46 | W 9-6 | 29-17 | 1 | 34,931 | Derek Lowe | Mark Redman | Derek Lowe | Mark Redman | Keith Foulke | 249 | 188 | 61 |
| 2004-05-27 | vs OAK | 47 | L 2-15 | 29-18 | 1 | 35,438 | Bronson Arroyo | Mark Mulder | Mark Mulder | Bronson Arroyo | | 251 | 203 | 48 |
| 2004-05-28 | vs SEA | 48 | W 8-4 | 30-18 | 1 | 35,134 | Pedro Martinez | Joel Pineiro | Pedro Martinez | Joel Pineiro | | 259 | 207 | 52 |
| 2004-05-29 | vs SEA | 49 | L 4-5 | 30-19 | 2 | 35,250 | Tim Wakefield | Freddy Garcia | Freddy Garcia | Tim Wakefield | Eddie Guardado | 263 | 212 | 51 |
| 2004-05-30 | vs SEA | 50 | W 9-7 | 31-19 | 1 | 35,046 | Curt Schilling | Ryan Franklin | Anastacio Martinez | J.J. Putz | | 272 | 219 | 53 |
| 2004-05-31 | vs BAL | 51 | L 4-13 | 31-20 | 2 | 35,465 | Derek Lowe | Rodrigo Lopez | Rodrigo Lopez | Derek Lowe | | 276 | 232 | 44 |
| 2004-06-01 | @ ANA | 52 | L 6-7 | 31-21 | 2 | 43,285 | Bronson Arroyo | Bartolo Colon | Kevin Gregg | Bronson Arroyo | Troy Percival | 282 | 239 | 43 |
| 2004-06-02 | @ ANA | 53 | L 7-10 | 31-22 | 2 | 43,205 | Pedro Martinez | Jarrod Washburn | Ramon Ortiz | Mike Timlin | Francisco Rodriguez | 289 | 249 | 40 |
| 2004-06-04 | @ KCA | 54 | L 2-5 | 31-23 | 2 | 28,182 | Tim Wakefield | Jimmy Gobble | Jimmy Gobble | Tim Wakefield | Jeremy Affeldt | 291 | 254 | 37 |
| 2004-06-05 | @ KCA | 55 | W 8-4 | 32-23 | 2 | 29,968 | Curt Schilling | Darrell May | Curt Schilling | Darrell May | | 299 | 258 | 41 |
| 2004-06-06 | @ KCA | 56 | W 5-3 | 33-23 | 2 | 22,964 | Derek Lowe | Chris George | Derek Lowe | Jason Grimsley | Keith Foulke | 304 | 261 | 43 |
| 2004-06-08 | vs SDN | 57 | W 1-0 | 34-23 | 2 | 35,205 | Pedro Martinez | David Wells | Pedro Martinez | Antonio Osuna | Keith Foulke | 305 | 261 | 44 |
| 2004-06-09 | vs SDN | 58 | L 1-8 | 34-24 | 2 | 35,064 | Bronson Arroyo | Brian Lawrence | Brian Lawrence | Bronson Arroyo | | 306 | 269 | 37 |
| 2004-06-10 | vs SDN | 59 | W 9-3 | 35-24 | 2 | 35,068 | Curt Schilling | Ismael Valdez | Curt Schilling | Ismael Valdez | | 315 | 272 | 43 |
| 2004-06-11 | vs LAN | 60 | W 2-1 | 36-24 | 2 | 35,173 | Derek Lowe | Odalis Perez | Keith Foulke | Tom Martin | | 317 | 273 | 44 |
| 2004-06-12 | vs LAN | 61 | L 5-14 | 36-25 | 2 | 34,671 | Tim Wakefield | Jeff Weaver | Jeff Weaver | Tim Wakefield | | 322 | 287 | 35 |
| 2004-06-13 | vs LAN | 62 | W 4-1 | 37-25 | 2 | 35,068 | Pedro Martinez | Hideo Nomo | Pedro Martinez | Hideo Nomo | Keith Foulke | 326 | 288 | 38 |
| 2004-06-15 | @ COL | 63 | L 3-6 | 37-26 | 2 | 40,489 | Bronson Arroyo | Joe Kennedy | Joe Kennedy | Bronson Arroyo | Shawn Chacon | 329 | 294 | 35 |
| 2004-06-16 | @ COL | 64 | L 6-7 | 37-27 | 2 | 39,319 | Curt Schilling | Jason Jennings | Jason Jennings | Curt Schilling | Shawn Chacon | 335 | 301 | 34 |
| 2004-06-17 | @ COL | 65 | W 11-0 | 38-27 | 2 | 40,088 | Derek Lowe | Aaron Cook | Derek Lowe | Aaron Cook | | 346 | 301 | 45 |
| 2004-06-18 | @ SFN | 66 | W 14-9 | 39-27 | 2 | 42,557 | Tim Wakefield | Jerome Williams | Mike Timlin | Jerome Williams | | 360 | 310 | 50 |
| 2004-06-19 | @ SFN | 67 | L 4-6 | 39-28 | 2 | 42,499 | Pedro Martinez | Noah Lowry | Matt Herges | Alan Embree | | 364 | 316 | 48 |
| 2004-06-20 | @ SFN | 68 | L 0-4 | 39-29 | 2 | 42,568 | Bronson Arroyo | Jason Schmidt | Jason Schmidt | Bronson Arroyo | | 364 | 320 | 44 |
| 2004-06-22 | vs MIN | 69 | W 9-2 | 40-29 | 2 | 35,261 | Curt Schilling | Kyle Lohse | Curt Schilling | Kyle Lohse | | 373 | 322 | 51 |
| 2004-06-23 | vs MIN | 70 | L 2-4 | 40-30 | 2 | 35,233 | Derek Lowe | Carlos Silva | Carlos Silva | Derek Lowe | Joe Nathan | 375 | 326 | 49 |
| 2004-06-24 | vs MIN | 71 | L 3-4 | 40-31 | 2 | 34,827 | Tim Wakefield | Brad Radke | Grant Balfour | Keith Foulke | Joe Nathan | 378 | 330 | 48 |
| 2004-06-25 | vs PHI | 72 | W 12-1 | 41-31 | 2 | 35,059 | Pedro Martinez | Paul Abbott | Pedro Martinez | Paul Abbott | | 390 | 331 | 59 |
| 2004-06-26 | vs PHI | 73 | L 2-9 | 41-32 | 2 | 34,712 | Bronson Arroyo | Randy Wolf | Ryan Madson | Bronson Arroyo | | 392 | 340 | 52 |
| 2004-06-27 | vs PHI | 74 | W 12-3 | 42-32 | 2 | 34,739 | Curt Schilling | Brett Myers | Curt Schilling | Brett Myers | | 404 | 343 | 61 |
| 2004-06-29 | @ NYA | 75 | L 3-11 | 42-33 | 2 | 55,231 | Derek Lowe | Javier Vazquez | Javier Vazquez | Derek Lowe | | 407 | 354 | 53 |
| 2004-06-30 | @ NYA | 76 | L 2-4 | 42-34 | 2 | 55,023 | Tim Wakefield | Jon Lieber | Tom Gordon | Mike Timlin | Mariano Rivera | 409 | 358 | 51 |
| 2004-07-01 | @ NYA | 77 | L 4-5 | 42-35 | 2 | 55,265 | Pedro Martinez | Brad Halsey | Tanyon Sturtze | Curt Leskanic | | 413 | 363 | 50 |
| 2004-07-02 | @ ATL | 78 | L 3-6 | 42-36 | 2 | 42,231 | Bronson Arroyo | Jaret Wright | Juan Cruz | Anastacio Martinez | | 416 | 369 | 47 |
| 2004-07-03 | @ ATL | 79 | W 6-1 | 43-36 | 2 | 51,831 | Curt Schilling | John Thomson | Curt Schilling | John Thomson | | 422 | 370 | 52 |
| 2004-07-04 | @ ATL | 80 | L 4-10 | 43-37 | 2 | 41,414 | Derek Lowe | Mike Hampton | Mike Hampton | Derek Lowe | | 426 | 380 | 46 |
| 2004-07-06 | vs OAK | 81 | W 11-0 | 44-37 | 2 | 35,302 | Tim Wakefield | Barry Zito | Tim Wakefield | Barry Zito | | 437 | 380 | 57 |
| 2004-07-07 | vs OAK | 82 | W 11-3 | 45-37 | 2 | 35,012 | Pedro Martinez | Mark Redman | Pedro Martinez | Mark Redman | | 448 | 383 | 65 |
| 2004-07-08 | vs OAK | 83 | W 8-7 | 46-37 | 2 | 35,144 | Curt Schilling | Rich Harden | Curt Leskanic | Justin Lehr | | 456 | 390 | 66 |
| 2004-07-09 | vs TEX | 84 | W 7-0 | 47-37 | 2 | 35,030 | Bronson Arroyo | Joaquin Benoit | Bronson Arroyo | Joaquin Benoit | | 463 | 390 | 73 |
| 2004-07-10 | vs TEX | 85 | W 14-6 | 48-37 | 2 | 35,024 | Derek Lowe | Kenny Rogers | Derek Lowe | Kenny Rogers | | 477 | 396 | 81 |
| 2004-07-11 | vs TEX | 86 | L 5-6 | 48-38 | 2 | 34,778 | Tim Wakefield | Ryan Drese | Brian Shouse | Keith Foulke | Francisco Cordero | 482 | 402 | 80 |
| 2004-07-15 | @ ANA | 87 | L 1-8 | 48-39 | 2 | 43,623 | Derek Lowe | Jarrod Washburn | Jarrod Washburn | Derek Lowe | | 483 | 410 | 73 |
| 2004-07-16 | @ ANA | 88 | W 4-2 | 49-39 | 2 | 43,771 | Pedro Martinez | Kelvim Escobar | Pedro Martinez | Kelvim Escobar | Keith Foulke | 487 | 412 | 75 |
| 2004-07-17 | @ ANA | 89 | L 3-8 | 49-40 | 2 | 43,746 | Tim Wakefield | Bartolo Colon | Bartolo Colon | Tim Wakefield | | 490 | 420 | 70 |
| 2004-07-18 | @ ANA | 90 | W 6-2 | 50-40 | 2 | 43,613 | Curt Schilling | John Lackey | Curt Schilling | John Lackey | | 496 | 422 | 74 |
| 2004-07-19 | @ SEA | 91 | L 4-8 | 50-41 | 2 | 42,898 | Bronson Arroyo | Ron Villone | Mike Myers | Curt Leskanic | | 500 | 430 | 70 |
| 2004-07-20 | @ SEA | 92 | W 9-7 | 51-41 | 2 | 46,024 | Derek Lowe | Joel Pineiro | Derek Lowe | Joel Pineiro | Keith Foulke | 509 | 437 | 72 |
| 2004-07-21 | vs BAL | 93 | L 5-10 | 51-42 | 2 | 35,023 | Pedro Martinez | Erik Bedard | Erik Bedard | Pedro Martinez | | 514 | 447 | 67 |
| 2004-07-22 | vs BAL | 94 | L 3-8 | 52-43 | 2 | 34,697 | Abe Alvarez | Rodrigo Lopez | Rodrigo Lopez | Abe Alvarez | | 517 | 455 | 62 |
| 2004-07-22 | vs BAL | 95 | W 4-0 | 52-43 | 2 | 35,370 | Tim Wakefield | Dave Borkowski | Tim Wakefield | Dave Borkowski | | 521 | 455 | 66 |
| 2004-07-23 | vs NYA | 96 | L 7-8 | 52-44 | 2 | 34,933 | Curt Schilling | Jon Lieber | Tom Gordon | Keith Foulke | Mariano Rivera | 528 | 463 | 65 |
| 2004-07-24 | vs NYA | 97 | W 11-10 | 53-44 | 2 | 34,501 | Bronson Arroyo | Tanyon Sturtze | Ramiro Mendoza | Mariano Rivera | | 539 | 473 | 66 |
| 2004-07-25 | vs NYA | 98 | W 9-6 | 54-44 | 2 | 35,006 | Derek Lowe | Jose Contreras | Derek Lowe | Jose Contreras | Keith Foulke | 548 | 479 | 69 |
| 2004-07-26 | @ BAL | 99 | W 12-5 | 55-44 | 2 | 42,113 | Pedro Martinez | Erik Bedard | Pedro Martinez | Erik Bedard | | 560 | 484 | 76 |
| 2004-07-28 | @ BAL | 100 | L 1-4 | 55-45 | 2 | 45,780 | Curt Schilling | Dave Borkowski | Dave Borkowski | Curt Schilling | | 561 | 488 | 73 |
| 2004-07-30 | @ MIN | 101 | W 8-2 | 56-45 | 2 | 34,263 | Bronson Arroyo | Kyle Lohse | Bronson Arroyo | Kyle Lohse | | 569 | 490 | 79 |
| 2004-07-31 | @ MIN | 102 | L 4-5 | 56-46 | 2 | 40,283 | Derek Lowe | Brad Radke | Juan Rincon | Alan Embree | Joe Nathan | 573 | 495 | 78 |
| 2004-08-01 | @ MIN | 103 | L 3-4 | 56-47 | 2 | 38,751 | Pedro Martinez | Johan Santana | Johan Santana | Mike Timlin | Joe Nathan | 576 | 499 | 77 |
| 2004-08-02 | @ TBA | 104 | W 6-3 | 57-47 | 2 | 21,835 | Tim Wakefield | Mark Hendrickson | Tim Wakefield | Mark Hendrickson | Keith Foulke | 582 | 502 | 80 |
| 2004-08-03 | @ TBA | 105 | W 5-2 | 58-47 | 2 | 20,882 | Curt Schilling | Rob Bell | Curt Schilling | Rob Bell | | 587 | 504 | 83 |
| 2004-08-04 | @ TBA | 106 | L 4-5 | 58-48 | 2 | 18,133 | Bronson Arroyo | John Halama | Travis Harper | Bronson Arroyo | Danys Baez | 591 | 509 | 82 |
| 2004-08-06 | @ DET | 107 | L 3-4 | 58-49 | 2 | 40,674 | Derek Lowe | Mike Maroth | Roberto Novoa | Derek Lowe | Ugueth Urbina | 594 | 513 | 81 |
| 2004-08-07 | @ DET | 108 | W 7-4 | 59-49 | 2 | 42,607 | Pedro Martinez | Jeremy Bonderman | Pedro Martinez | Jeremy Bonderman | | 601 | 517 | 84 |
| 2004-08-08 | @ DET | 109 | W 11-9 | 60-49 | 2 | 40,098 | Tim Wakefield | Nate Robertson | Tim Wakefield | Nate Robertson | Keith Foulke | 612 | 526 | 86 |
| 2004-08-09 | vs TBA | 110 | L 3-8 | 60-50 | 2 | 35,172 | Curt Schilling | John Halama | John Halama | Curt Schilling | | 615 | 534 | 81 |
| 2004-08-10 | vs TBA | 111 | W 8-4 | 61-50 | 2 | 35,191 | Bronson Arroyo | Jorge Sosa | Bronson Arroyo | Jorge Sosa | | 623 | 538 | 85 |
| 2004-08-11 | vs TBA | 112 | W 14-4 | 62-50 | 2 | 35,091 | Derek Lowe | Dewon Brazelton | Derek Lowe | Dewon Brazelton | | 637 | 542 | 95 |
| 2004-08-12 | vs TBA | 113 | W 6-0 | 63-50 | 2 | 34,804 | Pedro Martinez | Mark Hendrickson | Pedro Martinez | Mark Hendrickson | | 643 | 542 | 101 |
| 2004-08-13 | vs CHA | 114 | L 7-8 | 63-51 | 2 | 35,028 | Tim Wakefield | Jose Contreras | Jose Contreras | Tim Wakefield | Shingo Takatsu | 650 | 550 | 100 |
| 2004-08-14 | vs CHA | 115 | W 4-3 | 64-51 | 2 | 35,012 | Curt Schilling | Jon Garland | Curt Schilling | Jon Adkins | Keith Foulke | 654 | 553 | 101 |
| 2004-08-15 | vs CHA | 116 | L 4-5 | 64-52 | 2 | 34,405 | Bronson Arroyo | Mark Buehrle | Mark Buehrle | Bronson Arroyo | Shingo Takatsu | 658 | 558 | 100 |
| 2004-08-16 | vs TOR | 117 | W 8-4 | 65-52 | 2 | 35,271 | Derek Lowe | Justin Miller | Derek Lowe | Justin Miller | Keith Foulke | 666 | 562 | 104 |
| 2004-08-17 | vs TOR | 118 | W 5-4 | 66-52 | 2 | 35,105 | Pedro Martinez | Ted Lilly | Keith Foulke | Kevin Frederick | | 671 | 566 | 105 |
| 2004-08-18 | vs TOR | 119 | W 6-4 | 67-52 | 2 | 34,867 | Tim Wakefield | Miguel Batista | Tim Wakefield | Miguel Batista | | 677 | 570 | 107 |
| 2004-08-20 | @ CHA | 120 | W 10-1 | 68-52 | 2 | 38,720 | Curt Schilling | Mark Buehrle | Curt Schilling | Mark Buehrle | | 687 | 571 | 116 |
| 2004-08-21 | @ CHA | 121 | W 10-7 | 69-52 | 2 | 37,303 | Bronson Arroyo | Josh Stewart | Bronson Arroyo | Josh Stewart | Keith Foulke | 697 | 578 | 119 |
| 2004-08-22 | @ CHA | 122 | W 6-5 | 70-52 | 2 | 34,355 | Derek Lowe | Freddy Garcia | Curt Leskanic | Damaso Marte | Keith Foulke | 703 | 583 | 120 |
| 2004-08-23 | @ TOR | 123 | L 0-3 | 70-53 | 2 | 27,145 | Pedro Martinez | Ted Lilly | Ted Lilly | Pedro Martinez | | 703 | 586 | 117 |
| 2004-08-24 | @ TOR | 124 | W 5-4 | 71-53 | 2 | 22,217 | Tim Wakefield | Miguel Batista | Tim Wakefield | Miguel Batista | Keith Foulke | 708 | 590 | 118 |
| 2004-08-25 | @ TOR | 125 | W 11-5 | 72-53 | 2 | 22,479 | Curt Schilling | Josh Towers | Curt Schilling | Josh Towers | | 719 | 595 | 124 |
| 2004-08-26 | vs DET | 126 | W 4-1 | 73-53 | 2 | 35,153 | Bronson Arroyo | Jason Johnson | Bronson Arroyo | Jason Johnson | Keith Foulke | 723 | 596 | 127 |
| 2004-08-27 | vs DET | 127 | W 5-3 | 74-53 | 2 | 35,018 | Derek Lowe | Mike Maroth | Derek Lowe | Mike Maroth | Curt Leskanic | 728 | 599 | 129 |
| 2004-08-28 | vs DET | 128 | W 5-1 | 75-53 | 2 | 35,032 | Pedro Martinez | Jeremy Bonderman | Pedro Martinez | Jeremy Bonderman | | 733 | 600 | 133 |
| 2004-08-29 | vs DET | 129 | W 6-1 | 76-53 | 2 | 34,268 | Tim Wakefield | Wil Ledezma | Tim Wakefield | Wil Ledezma | | 739 | 601 | 138 |
| 2004-08-31 | vs ANA | 130 | W 10-7 | 77-53 | 2 | 35,040 | Curt Schilling | John Lackey | Curt Schilling | John Lackey | Keith Foulke | 749 | 608 | 141 |
| 2004-09-01 | vs ANA | 131 | W 12-7 | 78-53 | 2 | 35,076 | Bronson Arroyo | Aaron Sele | Terry Adams | Aaron Sele | | 761 | 615 | 146 |
| 2004-09-02 | vs ANA | 132 | W 4-3 | 79-53 | 2 | 35,050 | Derek Lowe | Bartolo Colon | Derek Lowe | Bartolo Colon | Keith Foulke | 765 | 618 | 147 |
| 2004-09-03 | vs TEX | 133 | W 2-0 | 80-53 | 2 | 35,151 | Pedro Martinez | John Wasdin | Pedro Martinez | John Wasdin | Keith Foulke | 767 | 618 | 149 |
| 2004-09-04 | vs TEX | 134 | L 6-8 | 80-54 | 2 | 34,670 | Tim Wakefield | Chris Young | Chris Young | Tim Wakefield | Francisco Cordero | 773 | 626 | 147 |
| 2004-09-05 | vs TEX | 135 | W 6-5 | 81-54 | 2 | 34,652 | Curt Schilling | Ryan Drese | Curt Schilling | Ryan Drese | | 779 | 631 | 148 |
| 2004-09-06 | @ OAK | 136 | W 8-3 | 82-54 | 2 | 37,839 | Bronson Arroyo | Barry Zito | Bronson Arroyo | Barry Zito | | 787 | 634 | 153 |
| 2004-09-07 | @ OAK | 137 | W 7-1 | 83-54 | 2 | 29,659 | Derek Lowe | Mark Redman | Derek Lowe | Mark Redman | | 794 | 635 | 159 |
| 2004-09-08 | @ OAK | 138 | W 8-3 | 84-54 | 2 | 39,575 | Pedro Martinez | Tim Hudson | Pedro Martinez | Tim Hudson | Keith Foulke | 802 | 638 | 164 |
| 2004-09-09 | @ SEA | 139 | L 1-7 | 84-55 | 2 | 29,656 | Tim Wakefield | Bobby Madritsch | Bobby Madritsch | Tim Wakefield | | 803 | 645 | 158 |
| 2004-09-10 | @ SEA | 140 | W 13-2 | 85-55 | 2 | 38,100 | Curt Schilling | Ryan Franklin | Curt Schilling | Ryan Franklin | | 816 | 647 | 169 |
| 2004-09-11 | @ SEA | 141 | W 9-0 | 86-55 | 2 | 44,401 | Bronson Arroyo | Jamie Moyer | Bronson Arroyo | Jamie Moyer | | 825 | 647 | 178 |
| 2004-09-12 | @ SEA | 142 | L 0-2 | 86-56 | 2 | 43,742 | Derek Lowe | Gil Meche | Gil Meche | Derek Lowe | | 825 | 649 | 176 |
| 2004-09-14 | vs TBA | 143 | L 2-5 | 86-57 | 2 | 35,118 | Pedro Martinez | Scott Kazmir | Scott Kazmir | Pedro Martinez | Danys Baez | 827 | 654 | 173 |
| 2004-09-15 | vs TBA | 144 | W 8-6 | 87-57 | 2 | 35,105 | Tim Wakefield | Dewon Brazelton | Mike Myers | Franklin Nunez | Keith Foulke | 835 | 660 | 175 |
| 2004-09-16 | vs TBA | 145 | W 11-4 | 88-57 | 2 | 35,048 | Curt Schilling | Mark Hendrickson | Curt Schilling | Mark Hendrickson | | 846 | 664 | 182 |
| 2004-09-17 | @ NYA | 146 | W 3-2 | 89-57 | 2 | 55,128 | Bronson Arroyo | Orlando Hernandez | Mike Timlin | Mariano Rivera | Keith Foulke | 849 | 666 | 183 |
| 2004-09-18 | @ NYA | 147 | L 4-14 | 89-58 | 2 | 55,153 | Derek Lowe | Jon Lieber | Jon Lieber | Derek Lowe | | 853 | 680 | 173 |
| 2004-09-19 | @ NYA | 148 | L 1-11 | 89-59 | 2 | 55,142 | Pedro Martinez | Mike Mussina | Mike Mussina | Pedro Martinez | | 854 | 691 | 163 |
| 2004-09-20 | vs BAL | 149 | L 6-9 | 89-60 | 2 | 34,758 | Tim Wakefield | Matt Riley | Jason Grimsley | Tim Wakefield | Jorge Julio | 860 | 700 | 160 |
| 2004-09-21 | vs BAL | 150 | W 3-2 | 90-60 | 2 | 35,083 | Curt Schilling | Rodrigo Lopez | Keith Foulke | B.J. Ryan | | 863 | 702 | 161 |
| 2004-09-22 | vs BAL | 151 | W 7-6 | 91-60 | 2 | 35,103 | Bronson Arroyo | Sidney Ponson | Curt Leskanic | Rick Bauer | | 870 | 708 | 162 |
| 2004-09-23 | vs BAL | 152 | L 7-9 | 91-61 | 2 | 35,026 | Derek Lowe | Daniel Cabrera | Todd Williams | Ramiro Mendoza | | 877 | 717 | 160 |
| 2004-09-24 | vs NYA | 153 | L 4-6 | 91-62 | 2 | 35,022 | Pedro Martinez | Mike Mussina | Tom Gordon | Pedro Martinez | Mariano Rivera | 881 | 723 | 158 |
| 2004-09-25 | vs NYA | 154 | W 12-5 | 92-62 | 2 | 34,856 | Tim Wakefield | Javier Vazquez | Keith Foulke | Paul Quantrill | | 893 | 728 | 165 |
| 2004-09-26 | vs NYA | 155 | W 11-4 | 93-62 | 2 | 34,582 | Curt Schilling | Kevin Brown | Curt Schilling | Kevin Brown | | 904 | 732 | 172 |
| 2004-09-27 | @ TBA | 156 | W 7-3 | 94-62 | 2 | 17,602 | Bronson Arroyo | Scott Kazmir | Bronson Arroyo | Jorge Sosa | | 911 | 735 | 176 |
| 2004-09-28 | @ TBA | 157 | W 10-8 | 95-62 | 2 | 20,116 | Derek Lowe | John Halama | Ramiro Mendoza | Danys Baez | Keith Foulke | 921 | 743 | 178 |
| 2004-09-29 | @ TBA | 158 | L 4-9 | 95-63 | 2 | 21,274 | Pedro Martinez | Doug Waechter | Doug Waechter | Pedro Martinez | Trever Miller | 925 | 752 | 173 |
| 2004-10-01 | @ BAL | 159 | W 8-3 | 96-63 | 2 | 39,086 | Tim Wakefield | Rodrigo Lopez | Tim Wakefield | Rodrigo Lopez | | 933 | 755 | 178 |
| 2004-10-02 | @ BAL | 160 | W 7-5 | 98-63 | 2 | 48,540 | Bronson Arroyo | Daniel Cabrera | Terry Adams | Daniel Cabrera | Keith Foulke | 940 | 760 | 180 |
| 2004-10-02 | @ BAL | 161 | W 7-5 | 98-63 | 2 | 47,320 | Pedro Astacio | Sidney Ponson | Byung-Hyun Kim | Jason Grimsley | Curt Leskanic | 947 | 765 | 182 |
| 2004-10-03 | @ BAL | 162 | L 2-3 | 98-64 | 2 | 42,104 | Derek Lowe | Rick Bauer | Bruce Chen | Scott Williamson | B.J. Ryan | 949 | 768 | 181 |