| 2004-04-05 | vs DET | 1 | L 0-7 | 0-1 | 5 | 47,817 | Roy Halladay | Jason Johnson | Jason Johnson | Roy Halladay | | 0 | 7 | -7 |
| 2004-04-06 | vs DET | 2 | L 3-7 | 0-2 | 5 | 21,003 | Miguel Batista | Mike Maroth | Mike Maroth | Miguel Batista | Nate Robertson | 3 | 14 | -11 |
| 2004-04-07 | vs DET | 3 | L 3-6 | 0-3 | 5 | 13,100 | Pat Hentgen | Jeremy Bonderman | Jeremy Bonderman | Pat Hentgen | | 6 | 20 | -14 |
| 2004-04-09 | @ BOS | 4 | W 10-5 | 1-3 | 5 | 34,337 | Ted Lilly | Bronson Arroyo | Justin Speier | Mike Timlin | | 16 | 25 | -9 |
| 2004-04-10 | @ BOS | 5 | L 1-4 | 1-4 | 5 | 35,305 | Roy Halladay | Pedro Martinez | Pedro Martinez | Roy Halladay | Keith Foulke | 17 | 29 | -12 |
| 2004-04-11 | @ BOS | 6 | L 4-6 | 1-5 | 5 | 34,286 | Miguel Batista | Curt Schilling | Mark Malaska | Aquilino Lopez | | 21 | 35 | -14 |
| 2004-04-13 | @ DET | 7 | W 7-5 | 2-5 | 5 | 8,804 | Pat Hentgen | Jeremy Bonderman | Terry Adams | Danny Patterson | Justin Speier | 28 | 40 | -12 |
| 2004-04-14 | @ DET | 8 | L 3-5 | 2-6 | 5 | 15,129 | Ted Lilly | Nate Robertson | Nate Robertson | Ted Lilly | Danny Patterson | 31 | 45 | -14 |
| 2004-04-15 | @ DET | 9 | W 11-0 | 3-6 | 5 | 17,572 | Roy Halladay | Jason Johnson | Roy Halladay | Jason Johnson | | 42 | 45 | -3 |
| 2004-04-16 | vs BAL | 10 | L 2-11 | 3-7 | 5 | 14,239 | Miguel Batista | Matt Riley | Matt Riley | Miguel Batista | | 44 | 56 | -12 |
| 2004-04-17 | vs BAL | 11 | L 3-5 | 3-8 | 5 | 20,177 | Josh Towers | Kurt Ainsworth | B.J. Ryan | Justin Speier | Jorge Julio | 47 | 61 | -14 |
| 2004-04-18 | vs BAL | 12 | L 0-7 | 3-9 | 5 | 16,842 | Pat Hentgen | Eric DuBose | Eric DuBose | Pat Hentgen | | 47 | 68 | -21 |
| 2004-04-20 | vs BOS | 13 | L 2-4 | 3-10 | 5 | 26,010 | Roy Halladay | Pedro Martinez | Pedro Martinez | Roy Halladay | Keith Foulke | 49 | 72 | -23 |
| 2004-04-21 | vs BOS | 14 | L 2-4 | 3-11 | 5 | 16,163 | Ted Lilly | Tim Wakefield | Tim Wakefield | Ted Lilly | Keith Foulke | 51 | 76 | -25 |
| 2004-04-22 | vs BOS | 15 | W 7-3 | 4-11 | 5 | 16,480 | Miguel Batista | Curt Schilling | Terry Adams | Curt Schilling | | 58 | 79 | -21 |
| 2004-04-23 | @ BAL | 16 | L 3-11 | 4-12 | 5 | 26,827 | Josh Towers | Eric DuBose | Eric DuBose | Josh Towers | | 61 | 90 | -29 |
| 2004-04-24 | @ BAL | 17 | W 5-4 | 5-12 | 5 | 41,093 | Pat Hentgen | Erik Bedard | Kerry Ligtenberg | Mike DeJean | | 66 | 94 | -28 |
| 2004-04-25 | @ BAL | 18 | W 15-3 | 6-12 | 5 | 31,028 | Roy Halladay | Sidney Ponson | Roy Halladay | Sidney Ponson | | 81 | 97 | -16 |
| 2004-04-26 | @ MIN | 19 | W 6-1 | 7-12 | 5 | 13,859 | Ted Lilly | Brad Radke | Ted Lilly | Brad Radke | | 87 | 98 | -11 |
| 2004-04-27 | @ MIN | 20 | L 4-7 | 7-13 | 5 | 14,029 | Miguel Batista | Johan Santana | Juan Rincon | Justin Speier | | 91 | 105 | -14 |
| 2004-04-28 | @ MIN | 21 | L 5-9 | 7-14 | 5 | 15,164 | Justin Miller | Kyle Lohse | Juan Rincon | Jason Frasor | | 96 | 114 | -18 |
| 2004-04-29 | @ CHA | 22 | L 4-6 | 7-15 | 5 | 11,210 | Pat Hentgen | Esteban Loaiza | Esteban Loaiza | Micheal Nakamura | Billy Koch | 100 | 120 | -20 |
| 2004-05-01 | @ CHA | 23 | L 3-4 | 8-16 | 4 | 0 | Roy Halladay | Mark Buehrle | Shingo Takatsu | Justin Speier | | 103 | 124 | -21 |
| 2004-05-01 | @ CHA | 24 | W 10-6 | 8-16 | 4 | 22,072 | Ted Lilly | Dan Wright | Ted Lilly | Dan Wright | | 113 | 130 | -17 |
| 2004-05-02 | @ CHA | 25 | L 2-3 | 8-17 | 5 | 15,550 | Miguel Batista | Jon Garland | Jon Garland | Miguel Batista | Billy Koch | 115 | 133 | -18 |
| 2004-05-03 | vs KCA | 26 | L 2-3 | 8-18 | 5 | 13,007 | Justin Miller | Jimmy Gobble | Nate Field | Terry Adams | Jaime Cerda | 117 | 136 | -19 |
| 2004-05-04 | vs KCA | 27 | W 5-4 | 9-18 | 5 | 20,011 | Pat Hentgen | Darrell May | Pat Hentgen | Darrell May | Jason Frasor | 122 | 140 | -18 |
| 2004-05-05 | vs KCA | 28 | W 10-3 | 10-18 | 4 | 14,103 | Roy Halladay | Brian Anderson | Roy Halladay | Brian Anderson | | 132 | 143 | -11 |
| 2004-05-07 | vs CHA | 29 | W 5-4 | 11-18 | 4 | 15,661 | Ted Lilly | Jon Garland | Terry Adams | Cliff Politte | | 137 | 147 | -10 |
| 2004-05-08 | vs CHA | 30 | W 4-2 | 12-18 | 4 | 18,368 | Miguel Batista | Scott Schoeneweis | Jason Frasor | Neal Cotts | Terry Adams | 141 | 149 | -8 |
| 2004-05-09 | vs CHA | 31 | W 5-2 | 13-18 | 4 | 17,546 | Justin Miller | Esteban Loaiza | Justin Miller | Esteban Loaiza | Kerry Ligtenberg | 146 | 151 | -5 |
| 2004-05-10 | @ KCA | 32 | W 9-3 | 14-18 | 4 | 13,803 | Pat Hentgen | Brian Anderson | Pat Hentgen | Brian Anderson | | 155 | 154 | 1 |
| 2004-05-11 | @ KCA | 33 | L 1-5 | 14-19 | 4 | 15,779 | Roy Halladay | Dennys Reyes | Shawn Camp | Roy Halladay | | 156 | 159 | -3 |
| 2004-05-12 | @ KCA | 34 | L 3-4 | 14-20 | 4 | 29,309 | Ted Lilly | Jeremy Affeldt | Nate Field | Terry Adams | | 159 | 163 | -4 |
| 2004-05-13 | vs BOS | 35 | W 12-6 | 15-20 | 4 | 20,876 | Miguel Batista | Curt Schilling | Miguel Batista | Curt Schilling | | 171 | 169 | 2 |
| 2004-05-14 | vs BOS | 36 | L 3-9 | 15-21 | 4 | 20,948 | Justin Miller | Derek Lowe | Alan Embree | Kerry Ligtenberg | | 174 | 178 | -4 |
| 2004-05-15 | vs BOS | 37 | L 0-4 | 15-22 | 4 | 36,841 | Pat Hentgen | Bronson Arroyo | Bronson Arroyo | Pat Hentgen | | 174 | 182 | -8 |
| 2004-05-16 | vs BOS | 38 | W 3-1 | 16-22 | 4 | 31,618 | Roy Halladay | Pedro Martinez | Roy Halladay | Pedro Martinez | Terry Adams | 177 | 183 | -6 |
| 2004-05-17 | vs MIN | 39 | L 5-9 | 16-23 | 4 | 13,502 | Ted Lilly | Brad Radke | Juan Rincon | Micheal Nakamura | Aaron Fultz | 182 | 192 | -10 |
| 2004-05-18 | vs MIN | 40 | W 5-3 | 17-23 | 4 | 25,405 | Miguel Batista | Johan Santana | Miguel Batista | Johan Santana | Terry Adams | 187 | 195 | -8 |
| 2004-05-19 | vs MIN | 41 | L 5-6 | 17-24 | 4 | 25,675 | Justin Miller | Kyle Lohse | Aaron Fultz | Terry Adams | Joe Nathan | 192 | 201 | -9 |
| 2004-05-21 | @ BOS | 42 | L 5-11 | 17-25 | 4 | 35,287 | Roy Halladay | Bronson Arroyo | Mike Timlin | Micheal Nakamura | | 197 | 212 | -15 |
| 2004-05-22 | @ BOS | 43 | L 2-5 | 17-26 | 4 | 35,196 | Ted Lilly | Pedro Martinez | Anastacio Martinez | Kerry Ligtenberg | Keith Foulke | 199 | 217 | -18 |
| 2004-05-23 | @ BOS | 44 | L 2-7 | 17-27 | 4 | 35,239 | Miguel Batista | Tim Wakefield | Tim Wakefield | Miguel Batista | | 201 | 224 | -23 |
| 2004-05-24 | vs ANA | 45 | W 6-5 | 18-27 | 4 | 15,301 | Justin Miller | John Lackey | Jason Frasor | Ben Weber | | 207 | 229 | -22 |
| 2004-05-26 | vs ANA | 46 | W 6-5 | 19-27 | 4 | 14,515 | Pat Hentgen | Bartolo Colon | Terry Adams | Troy Percival | | 213 | 234 | -21 |
| 2004-05-27 | vs ANA | 47 | W 3-2 | 20-27 | 4 | 14,773 | Roy Halladay | Jarrod Washburn | Roy Halladay | Jarrod Washburn | Jason Frasor | 216 | 236 | -20 |
| 2004-05-28 | vs TEX | 48 | W 5-4 | 21-27 | 4 | 16,394 | Ted Lilly | R.A. Dickey | Ted Lilly | R.A. Dickey | Jason Frasor | 221 | 240 | -19 |
| 2004-05-29 | vs TEX | 49 | W 6-2 | 22-27 | 4 | 30,704 | Miguel Batista | Juan Dominguez | Miguel Batista | Juan Dominguez | | 227 | 242 | -15 |
| 2004-05-30 | vs TEX | 50 | L 2-4 | 22-28 | 4 | 22,225 | Justin Miller | Kenny Rogers | Kenny Rogers | Justin Miller | Francisco Cordero | 229 | 246 | -17 |
| 2004-05-31 | @ SEA | 51 | L 2-6 | 22-29 | 4 | 27,856 | Pat Hentgen | Jamie Moyer | Jamie Moyer | Pat Hentgen | | 231 | 252 | -21 |
| 2004-06-01 | @ SEA | 52 | W 6-5 | 23-29 | 4 | 24,848 | Jason Kershner | Gil Meche | Aquilino Lopez | Clint Nageotte | Jason Frasor | 237 | 257 | -20 |
| 2004-06-02 | @ SEA | 53 | W 5-3 | 24-29 | 4 | 25,317 | Ted Lilly | Joel Pineiro | Ted Lilly | Joel Pineiro | Kerry Ligtenberg | 242 | 260 | -18 |
| 2004-06-03 | @ OAK | 54 | L 1-2 | 24-30 | 4 | 10,879 | Miguel Batista | Barry Zito | Chad Bradford | Terry Adams | | 243 | 262 | -19 |
| 2004-06-04 | @ OAK | 55 | W 6-1 | 25-30 | 4 | 12,822 | Josh Towers | Rich Harden | Josh Towers | Chad Bradford | Vinnie Chulk | 249 | 263 | -14 |
| 2004-06-05 | @ OAK | 56 | L 0-4 | 25-31 | 4 | 20,772 | Pat Hentgen | Tim Hudson | Tim Hudson | Pat Hentgen | | 249 | 267 | -18 |
| 2004-06-06 | @ OAK | 57 | L 3-8 | 25-32 | 4 | 24,092 | Jason Kershner | Mark Redman | Mark Redman | Jason Kershner | | 252 | 275 | -23 |
| 2004-06-08 | vs LAN | 58 | W 7-1 | 26-32 | 4 | 16,499 | Ted Lilly | Hideo Nomo | Ted Lilly | Hideo Nomo | | 259 | 276 | -17 |
| 2004-06-09 | vs LAN | 59 | W 4-0 | 27-32 | 4 | 18,003 | Miguel Batista | Jose Lima | Miguel Batista | Jose Lima | | 263 | 276 | -13 |
| 2004-06-10 | vs LAN | 60 | L 1-6 | 27-33 | 4 | 16,267 | Josh Towers | Kazuhisa Ishii | Kazuhisa Ishii | Josh Towers | | 264 | 282 | -18 |
| 2004-06-11 | vs ARI | 61 | L 2-3 | 27-34 | 4 | 14,259 | Pat Hentgen | Steve Sparks | Randy Choate | Jason Frasor | Jose Valverde | 266 | 285 | -19 |
| 2004-06-12 | vs ARI | 62 | W 15-4 | 28-34 | 4 | 30,349 | Roy Halladay | Andrew Good | Roy Halladay | Andrew Good | Vinnie Chulk | 281 | 289 | -8 |
| 2004-06-13 | vs ARI | 63 | L 3-5 | 28-35 | 4 | 22,766 | Ted Lilly | Randy Johnson | Randy Johnson | Ted Lilly | Jose Valverde | 284 | 294 | -10 |
| 2004-06-15 | @ SFN | 64 | L 3-4 | 28-36 | 5 | 36,737 | Miguel Batista | Jason Schmidt | Jason Schmidt | Miguel Batista | Matt Herges | 287 | 298 | -11 |
| 2004-06-16 | @ SFN | 65 | L 2-10 | 28-37 | 5 | 36,834 | Pat Hentgen | Kirk Rueter | Kirk Rueter | Pat Hentgen | | 289 | 308 | -19 |
| 2004-06-17 | @ SFN | 66 | L 5-8 | 28-38 | 5 | 40,464 | Roy Halladay | Dustin Hermanson | Jim Brower | Justin Speier | Matt Herges | 294 | 316 | -22 |
| 2004-06-18 | @ SDN | 67 | W 3-2 | 29-38 | 4 | 40,511 | Ted Lilly | David Wells | Ted Lilly | David Wells | Jason Frasor | 297 | 318 | -21 |
| 2004-06-19 | @ SDN | 68 | L 2-3 | 29-39 | 4 | 40,307 | Josh Towers | Dennis Tankersley | Scott Linebrink | Justin Speier | Trevor Hoffman | 299 | 321 | -22 |
| 2004-06-20 | @ SDN | 69 | W 3-0 | 30-39 | 4 | 41,060 | Miguel Batista | Brian Lawrence | Miguel Batista | Brian Lawrence | Jason Frasor | 302 | 321 | -19 |
| 2004-06-22 | vs TBA | 70 | L 1-5 | 30-40 | 4 | 15,646 | Pat Hentgen | Chad Gaudin | Travis Harper | Pat Hentgen | | 303 | 326 | -23 |
| 2004-06-23 | vs TBA | 71 | W 2-1 | 31-40 | 4 | 14,713 | Roy Halladay | Victor Zambrano | Jason Frasor | Jesus Colome | | 305 | 327 | -22 |
| 2004-06-24 | vs TBA | 72 | L 13-19 | 31-41 | 4 | 14,876 | Ted Lilly | John Halama | John Halama | Ted Lilly | | 318 | 346 | -28 |
| 2004-06-25 | vs MON | 73 | W 3-1 | 32-41 | 4 | 16,484 | Josh Towers | Zach Day | Josh Towers | Zach Day | Jason Frasor | 321 | 347 | -26 |
| 2004-06-26 | vs MON | 74 | W 10-5 | 33-41 | 4 | 23,875 | Miguel Batista | Scott Downs | Miguel Batista | Scott Downs | | 331 | 352 | -21 |
| 2004-06-27 | vs MON | 75 | L 4-9 | 33-42 | 4 | 25,915 | Pat Hentgen | Livan Hernandez | Livan Hernandez | Pat Hentgen | | 335 | 361 | -26 |
| 2004-06-28 | @ TBA | 76 | L 2-10 | 33-43 | 4 | 11,218 | Roy Halladay | Victor Zambrano | Victor Zambrano | Roy Halladay | | 337 | 371 | -34 |
| 2004-06-29 | @ TBA | 77 | W 4-0 | 34-43 | 4 | 11,640 | Ted Lilly | John Halama | Ted Lilly | John Halama | | 341 | 371 | -30 |
| 2004-06-30 | @ TBA | 78 | L 2-6 | 34-44 | 4 | 10,560 | Josh Towers | Dewon Brazelton | Dewon Brazelton | Josh Towers | | 343 | 377 | -34 |
| 2004-07-01 | @ TBA | 79 | W 14-0 | 35-44 | 4 | 14,417 | Miguel Batista | Mark Hendrickson | Miguel Batista | Mark Hendrickson | | 357 | 377 | -20 |
| 2004-07-02 | @ MON | 80 | L 0-2 | 35-45 | 5 | 8,220 | David Bush | Livan Hernandez | Livan Hernandez | David Bush | | 357 | 379 | -22 |
| 2004-07-03 | @ MON | 81 | W 2-0 | 36-45 | 4 | 8,831 | Roy Halladay | Tony Armas | Roy Halladay | Tony Armas | Jason Frasor | 359 | 379 | -20 |
| 2004-07-04 | @ MON | 82 | L 4-6 | 36-46 | 4 | 8,279 | Ted Lilly | Shawn Hill | Shawn Hill | Ted Lilly | Joe Horgan | 363 | 385 | -22 |
| 2004-07-06 | vs SEA | 83 | W 7-6 | 37-46 | 4 | 16,262 | Miguel Batista | Jamie Moyer | Miguel Batista | Jamie Moyer | Jason Frasor | 370 | 391 | -21 |
| 2004-07-07 | vs SEA | 84 | W 12-4 | 38-46 | 4 | 18,513 | Josh Towers | Travis Blackley | Josh Towers | Travis Blackley | | 382 | 395 | -13 |
| 2004-07-08 | vs SEA | 85 | W 10-8 | 39-46 | 4 | 16,188 | David Bush | Ryan Franklin | Justin Speier | Eddie Guardado | | 392 | 403 | -11 |
| 2004-07-09 | vs ANA | 86 | L 4-5 | 39-47 | 4 | 15,071 | Roy Halladay | Bartolo Colon | Bartolo Colon | Roy Halladay | Troy Percival | 396 | 408 | -12 |
| 2004-07-10 | vs ANA | 87 | L 2-11 | 39-48 | 4 | 20,635 | Ted Lilly | Kelvim Escobar | Kelvim Escobar | Ted Lilly | | 398 | 419 | -21 |
| 2004-07-11 | vs ANA | 88 | L 2-5 | 39-49 | 4 | 17,573 | Miguel Batista | John Lackey | John Lackey | Miguel Batista | Troy Percival | 400 | 424 | -24 |
| 2004-07-16 | @ TEX | 89 | L 2-11 | 39-50 | 4 | 44,348 | Roy Halladay | Ryan Drese | Ryan Drese | Roy Halladay | | 402 | 435 | -33 |
| 2004-07-17 | @ TEX | 90 | L 0-4 | 39-51 | 5 | 43,189 | Ted Lilly | Ricardo Rodriguez | Ricardo Rodriguez | Ted Lilly | | 402 | 439 | -37 |
| 2004-07-18 | @ TEX | 91 | L 5-7 | 39-52 | 5 | 24,334 | Miguel Batista | Kenny Rogers | Doug Brocail | Vinnie Chulk | Francisco Cordero | 407 | 446 | -39 |
| 2004-07-19 | @ OAK | 92 | W 5-3 | 40-52 | 5 | 15,480 | Josh Towers | Kirk Saarloos | Josh Towers | Kirk Saarloos | Jason Frasor | 412 | 449 | -37 |
| 2004-07-20 | @ OAK | 93 | L 0-1 | 40-53 | 5 | 18,885 | David Bush | Rich Harden | Justin Lehr | Justin Speier | | 412 | 450 | -38 |
| 2004-07-21 | @ NYA | 94 | L 3-10 | 40-54 | 5 | 53,031 | Pat Hentgen | Javier Vazquez | Javier Vazquez | Pat Hentgen | | 415 | 460 | -45 |
| 2004-07-22 | @ NYA | 95 | L 0-1 | 40-55 | 5 | 53,657 | Ted Lilly | Orlando Hernandez | Mariano Rivera | Vinnie Chulk | | 415 | 461 | -46 |
| 2004-07-23 | vs TBA | 96 | W 7-4 | 41-55 | 5 | 16,633 | Miguel Batista | Mark Hendrickson | Miguel Batista | Mark Hendrickson | Jason Frasor | 422 | 465 | -43 |
| 2004-07-24 | vs TBA | 97 | W 4-2 | 42-55 | 5 | 18,841 | Josh Towers | Rob Bell | Josh Towers | Rob Bell | Jason Frasor | 426 | 467 | -41 |
| 2004-07-25 | vs TBA | 98 | W 5-3 | 43-55 | 5 | 15,784 | David Bush | Victor Zambrano | David Bush | Victor Zambrano | Kerry Ligtenberg | 431 | 470 | -39 |
| 2004-07-26 | vs NYA | 99 | L 5-6 | 43-56 | 5 | 30,041 | Sean Douglass | Javier Vazquez | Mariano Rivera | Jason Frasor | | 436 | 476 | -40 |
| 2004-07-27 | vs NYA | 100 | L 4-7 | 43-57 | 5 | 30,087 | Ted Lilly | Orlando Hernandez | Scott Proctor | Kerry Ligtenberg | Tom Gordon | 440 | 483 | -43 |
| 2004-07-28 | vs NYA | 101 | W 3-2 | 44-57 | 5 | 31,385 | Miguel Batista | Jon Lieber | Jason Frasor | Scott Proctor | | 443 | 485 | -42 |
| 2004-07-30 | @ TBA | 102 | W 3-0 | 45-57 | 5 | 10,531 | Josh Towers | John Halama | Josh Towers | John Halama | Jason Frasor | 446 | 485 | -39 |
| 2004-07-31 | @ TBA | 103 | L 5-6 | 45-58 | 5 | 17,418 | David Bush | Jorge Sosa | Jorge Sosa | David Bush | Danys Baez | 451 | 491 | -40 |
| 2004-08-01 | @ TBA | 104 | L 3-5 | 45-59 | 5 | 10,750 | Sean Douglass | Dewon Brazelton | Dewon Brazelton | Sean Douglass | Danys Baez | 454 | 496 | -42 |
| 2004-08-02 | vs CLE | 105 | W 6-1 | 46-59 | 5 | 17,549 | Ted Lilly | Cliff Lee | Ted Lilly | Cliff Lee | | 460 | 497 | -37 |
| 2004-08-03 | vs CLE | 106 | W 7-6 | 47-59 | 5 | 15,025 | Miguel Batista | Scott Elarton | Justin Speier | Rafael Betancourt | Jason Frasor | 467 | 503 | -36 |
| 2004-08-04 | vs CLE | 107 | L 5-14 | 47-60 | 5 | 15,675 | Josh Towers | Jake Westbrook | Jake Westbrook | Josh Towers | | 472 | 517 | -45 |
| 2004-08-05 | vs CLE | 108 | L 3-6 | 47-61 | 5 | 30,037 | David Bush | Chad Durbin | Rafael Betancourt | Kerry Ligtenberg | Bob Wickman | 475 | 523 | -48 |
| 2004-08-06 | @ NYA | 109 | L 4-11 | 47-62 | 5 | 48,900 | Sean Douglass | Javier Vazquez | Javier Vazquez | Sean Douglass | | 479 | 534 | -55 |
| 2004-08-07 | @ NYA | 110 | L 0-6 | 47-63 | 5 | 54,025 | Ted Lilly | Orlando Hernandez | Orlando Hernandez | Ted Lilly | | 479 | 540 | -61 |
| 2004-08-08 | @ NYA | 111 | L 2-8 | 47-64 | 5 | 52,616 | Miguel Batista | Jon Lieber | Jon Lieber | Miguel Batista | | 481 | 548 | -67 |
| 2004-08-09 | @ NYA | 112 | W 5-4 | 48-64 | 5 | 49,853 | Josh Towers | Esteban Loaiza | Josh Towers | Esteban Loaiza | Jason Frasor | 486 | 552 | -66 |
| 2004-08-10 | @ CLE | 113 | L 0-2 | 48-65 | 5 | 19,942 | David Bush | Chad Durbin | Chad Durbin | David Bush | Bob Wickman | 486 | 554 | -68 |
| 2004-08-11 | @ CLE | 114 | L 2-3 | 48-66 | 5 | 23,696 | Justin Miller | CC Sabathia | CC Sabathia | Kevin Frederick | Bob Wickman | 488 | 557 | -69 |
| 2004-08-12 | @ CLE | 115 | L 2-6 | 48-67 | 5 | 22,734 | Ted Lilly | Cliff Lee | David Riske | Kerry Ligtenberg | | 490 | 563 | -73 |
| 2004-08-13 | vs BAL | 116 | L 0-4 | 48-68 | 5 | 21,234 | Miguel Batista | Sidney Ponson | Sidney Ponson | Miguel Batista | | 490 | 567 | -77 |
| 2004-08-14 | vs BAL | 117 | W 7-2 | 49-68 | 5 | 35,768 | Josh Towers | Dave Borkowski | Josh Towers | Dave Borkowski | | 497 | 569 | -72 |
| 2004-08-15 | vs BAL | 118 | L 7-11 | 49-69 | 5 | 26,132 | David Bush | Daniel Cabrera | Buddy Groom | Vinnie Chulk | | 504 | 580 | -76 |
| 2004-08-16 | @ BOS | 119 | L 4-8 | 49-70 | 5 | 35,271 | Justin Miller | Derek Lowe | Derek Lowe | Justin Miller | Keith Foulke | 508 | 588 | -80 |
| 2004-08-17 | @ BOS | 120 | L 4-5 | 49-71 | 5 | 35,105 | Ted Lilly | Pedro Martinez | Keith Foulke | Kevin Frederick | | 512 | 593 | -81 |
| 2004-08-18 | @ BOS | 121 | L 4-6 | 49-72 | 5 | 34,867 | Miguel Batista | Tim Wakefield | Tim Wakefield | Miguel Batista | | 516 | 599 | -83 |
| 2004-08-20 | @ BAL | 122 | W 14-4 | 50-72 | 5 | 35,024 | Josh Towers | Dave Borkowski | Josh Towers | Dave Borkowski | | 530 | 603 | -73 |
| 2004-08-21 | @ BAL | 123 | W 10-4 | 51-72 | 5 | 38,079 | David Bush | Daniel Cabrera | David Bush | Daniel Cabrera | | 540 | 607 | -67 |
| 2004-08-22 | @ BAL | 124 | W 8-5 | 52-72 | 5 | 44,482 | Justin Miller | Erik Bedard | Justin Miller | Erik Bedard | Jason Frasor | 548 | 612 | -64 |
| 2004-08-23 | vs BOS | 125 | W 3-0 | 53-72 | 5 | 27,145 | Ted Lilly | Pedro Martinez | Ted Lilly | Pedro Martinez | | 551 | 612 | -61 |
| 2004-08-24 | vs BOS | 126 | L 4-5 | 53-73 | 5 | 22,217 | Miguel Batista | Tim Wakefield | Tim Wakefield | Miguel Batista | Keith Foulke | 555 | 617 | -62 |
| 2004-08-25 | vs BOS | 127 | L 5-11 | 53-74 | 5 | 22,479 | Josh Towers | Curt Schilling | Curt Schilling | Josh Towers | | 560 | 628 | -68 |
| 2004-08-26 | vs NYA | 128 | L 4-7 | 53-75 | 5 | 35,682 | David Bush | Jon Lieber | C.J. Nitkowski | Jason Frasor | Mariano Rivera | 564 | 635 | -71 |
| 2004-08-27 | vs NYA | 129 | L 7-8 | 53-76 | 5 | 35,436 | Justin Miller | Esteban Loaiza | Tanyon Sturtze | Justin Miller | Tom Gordon | 571 | 643 | -72 |
| 2004-08-28 | vs NYA | 130 | L 6-18 | 53-77 | 5 | 43,541 | Ted Lilly | Kevin Brown | Kevin Brown | Ted Lilly | Mariano Rivera | 577 | 661 | -84 |
| 2004-08-29 | vs NYA | 131 | W 6-4 | 54-77 | 5 | 44,072 | Miguel Batista | Mike Mussina | Miguel Batista | Mike Mussina | Jason Frasor | 583 | 665 | -82 |
| 2004-08-31 | vs SEA | 132 | L 5-7 | 54-78 | 5 | 21,174 | Josh Towers | Jamie Moyer | Scott Atchison | Kerry Ligtenberg | J.J. Putz | 588 | 672 | -84 |
| 2004-09-01 | vs SEA | 133 | W 4-2 | 55-78 | 5 | 22,310 | David Bush | Gil Meche | David Bush | Ron Villone | Justin Speier | 592 | 674 | -82 |
| 2004-09-02 | vs SEA | 134 | W 8-6 | 56-78 | 5 | 23,374 | Justin Miller | Cha-Seung Baek | Bob File | Cha-Seung Baek | Justin Speier | 600 | 680 | -80 |
| 2004-09-03 | vs OAK | 135 | L 4-7 | 56-79 | 5 | 28,488 | Ted Lilly | Tim Hudson | Tim Hudson | Ted Lilly | Octavio Dotel | 604 | 687 | -83 |
| 2004-09-04 | vs OAK | 136 | L 5-9 | 56-80 | 5 | 29,149 | Miguel Batista | Mark Mulder | Chris Hammond | Jason Frasor | | 609 | 696 | -87 |
| 2004-09-05 | vs OAK | 137 | W 13-5 | 57-80 | 5 | 28,327 | Ryan Glynn | Rich Harden | Ryan Glynn | Rich Harden | | 622 | 701 | -79 |
| 2004-09-07 | @ ANA | 138 | L 2-5 | 57-81 | 5 | 36,277 | David Bush | Bartolo Colon | Bartolo Colon | David Bush | Troy Percival | 624 | 706 | -82 |
| 2004-09-08 | @ ANA | 139 | W 1-0 | 58-81 | 5 | 36,905 | Justin Miller | Kelvim Escobar | Justin Miller | Kelvim Escobar | Justin Speier | 625 | 706 | -81 |
| 2004-09-09 | @ ANA | 140 | W 5-4 | 59-81 | 5 | 37,514 | Ted Lilly | Jarrod Washburn | Ted Lilly | Jarrod Washburn | Justin Speier | 630 | 710 | -80 |
| 2004-09-10 | @ TEX | 141 | L 3-10 | 59-82 | 5 | 24,617 | Miguel Batista | Ryan Drese | Ryan Drese | Miguel Batista | | 633 | 720 | -87 |
| 2004-09-11 | @ TEX | 142 | L 7-10 | 59-83 | 5 | 40,587 | Ryan Glynn | Kenny Rogers | Ron Mahay | Jason Frasor | Francisco Cordero | 640 | 730 | -90 |
| 2004-09-12 | @ TEX | 143 | L 6-7 | 59-84 | 5 | 20,434 | David Bush | Chan Ho Park | Doug Brocail | Justin Speier | Francisco Cordero | 646 | 737 | -91 |
| 2004-09-13 | vs BAL | 144 | L 1-9 | 59-85 | 5 | 18,372 | Justin Miller | Bruce Chen | Bruce Chen | Justin Miller | | 647 | 746 | -99 |
| 2004-09-15 | vs BAL | 145 | W 3-0 | 60-85 | 5 | 19,942 | Ted Lilly | Matt Riley | Ted Lilly | Matt Riley | Justin Speier | 650 | 746 | -96 |
| 2004-09-16 | vs BAL | 146 | L 5-9 | 60-86 | 5 | 21,451 | Miguel Batista | Rodrigo Lopez | Rodrigo Lopez | Miguel Batista | | 655 | 755 | -100 |
| 2004-09-17 | vs TBA | 147 | L 4-11 | 60-87 | 5 | 25,987 | Josh Towers | Doug Waechter | Doug Waechter | Josh Towers | | 659 | 766 | -107 |
| 2004-09-18 | vs TBA | 148 | W 4-2 | 61-87 | 5 | 33,432 | David Bush | Todd Ritchie | David Bush | Todd Ritchie | Miguel Batista | 663 | 768 | -105 |
| 2004-09-19 | vs TBA | 149 | W 9-7 | 62-87 | 5 | 30,714 | Justin Miller | Scott Kazmir | Vinnie Chulk | Scott Kazmir | Justin Speier | 672 | 775 | -103 |
| 2004-09-20 | @ NYA | 150 | W 6-3 | 63-87 | 5 | 10,732 | Gustavo Chacin | Javier Vazquez | Gustavo Chacin | Javier Vazquez | Miguel Batista | 678 | 778 | -100 |
| 2004-09-21 | @ NYA | 151 | L 3-5 | 63-88 | 5 | 36,675 | Roy Halladay | Esteban Loaiza | Esteban Loaiza | Roy Halladay | Mariano Rivera | 681 | 783 | -102 |
| 2004-09-22 | @ NYA | 152 | W 5-4 | 64-88 | 5 | 49,560 | Ted Lilly | Orlando Hernandez | Ted Lilly | Orlando Hernandez | Miguel Batista | 686 | 787 | -101 |
| 2004-09-24 | @ TBA | 153 | L 2-4 | 64-89 | 5 | 13,003 | Josh Towers | Mark Hendrickson | Mark Hendrickson | Josh Towers | Danys Baez | 688 | 791 | -103 |
| 2004-09-25 | @ TBA | 154 | L 5-6 | 64-90 | 5 | 20,978 | David Bush | Dewon Brazelton | Danys Baez | Miguel Batista | | 693 | 797 | -104 |
| 2004-09-27 | @ BAL | 155 | W 4-1 | 65-90 | 5 | 17,809 | Roy Halladay | Sidney Ponson | Brandon League | Sidney Ponson | Miguel Batista | 697 | 798 | -101 |
| 2004-09-29 | @ BAL | 156 | L 6-7 | 65-92 | 5 | 0 | Ted Lilly | Bruce Chen | B.J. Ryan | Justin Speier | | 703 | 805 | -102 |
| 2004-09-29 | @ BAL | 157 | L 0-4 | 65-92 | 5 | 20,600 | Gustavo Chacin | Rick Bauer | Rick Bauer | Gustavo Chacin | | 703 | 809 | -106 |
| 2004-09-30 | @ BAL | 158 | L 3-9 | 65-93 | 5 | 18,793 | Josh Towers | Matt Riley | Matt Riley | Josh Towers | | 706 | 818 | -112 |
| 2004-10-01 | vs NYA | 159 | W 7-0 | 66-93 | 5 | 48,914 | David Bush | Orlando Hernandez | David Bush | Orlando Hernandez | | 713 | 818 | -105 |
| 2004-10-02 | vs NYA | 160 | W 4-2 | 67-93 | 5 | 50,498 | Roy Halladay | Kevin Brown | Roy Halladay | Kevin Brown | Miguel Batista | 717 | 820 | -103 |
| 2004-10-03 | vs NYA | 161 | L 2-3 | 67-94 | 5 | 49,948 | Josh Towers | Brad Halsey | Scott Proctor | Josh Towers | Tanyon Sturtze | 719 | 823 | -104 |