| 2004-03-30 | vs NYA | 1 | W 8-3 | 1-0 | 1 | 55,000 | Victor Zambrano | Mike Mussina | Victor Zambrano | Mike Mussina | | 8 | 3 | 5 |
| 2004-03-31 | vs NYA | 2 | L 1-12 | 1-1 | 2 | 55,000 | Geremi Gonzalez | Kevin Brown | Kevin Brown | Geremi Gonzalez | | 9 | 15 | -6 |
| 2004-04-06 | vs NYA | 3 | W 9-4 | 2-1 | 1 | 41,755 | Victor Zambrano | Mike Mussina | Victor Zambrano | Mike Mussina | | 18 | 19 | -1 |
| 2004-04-07 | vs NYA | 4 | L 2-3 | 2-2 | 3 | 31,669 | Paul Abbott | Kevin Brown | Kevin Brown | Paul Abbott | Mariano Rivera | 20 | 22 | -2 |
| 2004-04-09 | vs BAL | 5 | W 4-3 | 3-2 | 1 | 12,123 | Mark Hendrickson | Sidney Ponson | Danys Baez | John Parrish | | 24 | 25 | -1 |
| 2004-04-10 | vs BAL | 6 | L 3-11 | 3-3 | 3 | 14,093 | Geremi Gonzalez | Erik Bedard | Rick Bauer | Geremi Gonzalez | | 27 | 36 | -9 |
| 2004-04-11 | vs BAL | 7 | W 10-1 | 4-3 | 2 | 10,269 | Victor Zambrano | Eric DuBose | Victor Zambrano | Eric DuBose | | 37 | 37 | 0 |
| 2004-04-14 | @ NYA | 8 | L 1-5 | 4-4 | 3 | 37,914 | Mark Hendrickson | Kevin Brown | Kevin Brown | Mark Hendrickson | | 38 | 42 | -4 |
| 2004-04-16 | vs CHA | 9 | W 3-0 | 5-4 | 3 | 12,108 | Paul Abbott | Dan Wright | Paul Abbott | Dan Wright | Danys Baez | 41 | 42 | -1 |
| 2004-04-17 | vs CHA | 10 | L 1-4 | 5-5 | 3 | 14,302 | Victor Zambrano | Scott Schoeneweis | Scott Schoeneweis | Victor Zambrano | Damaso Marte | 42 | 46 | -4 |
| 2004-04-18 | vs CHA | 11 | L 0-5 | 5-6 | 4 | 12,072 | Geremi Gonzalez | Esteban Loaiza | Esteban Loaiza | Geremi Gonzalez | | 42 | 51 | -9 |
| 2004-04-20 | @ BAL | 12 | L 1-9 | 5-7 | 4 | 21,902 | Mark Hendrickson | Sidney Ponson | Sidney Ponson | Mark Hendrickson | | 43 | 60 | -17 |
| 2004-04-21 | @ BAL | 13 | W 7-3 | 6-7 | 4 | 20,781 | Paul Abbott | Matt Riley | Paul Abbott | Matt Riley | | 50 | 63 | -13 |
| 2004-04-22 | @ BAL | 14 | L 6-7 | 6-8 | 4 | 19,250 | Damian Moss | Kurt Ainsworth | John Parrish | Chad Gaudin | Jorge Julio | 56 | 70 | -14 |
| 2004-04-23 | @ CHA | 15 | L 2-3 | 6-9 | 4 | 12,049 | Victor Zambrano | Esteban Loaiza | Billy Koch | Danys Baez | | 58 | 73 | -15 |
| 2004-04-24 | @ CHA | 16 | W 4-1 | 7-9 | 4 | 17,062 | Doug Waechter | Dan Wright | Doug Waechter | Dan Wright | Danys Baez | 62 | 74 | -12 |
| 2004-04-25 | @ CHA | 17 | L 5-6 | 7-10 | 4 | 17,497 | Geremi Gonzalez | Mark Buehrle | Jon Adkins | Trever Miller | | 67 | 80 | -13 |
| 2004-04-28 | @ BOS | 18 | L 0-6 | 7-11 | 4 | 35,120 | Paul Abbott | Curt Schilling | Curt Schilling | Paul Abbott | | 67 | 86 | -19 |
| 2004-04-29 | @ BOS | 19 | L 0-4 | 7-13 | 4 | 35,614 | Victor Zambrano | Byung-Hyun Kim | Byung-Hyun Kim | Victor Zambrano | | 67 | 90 | -23 |
| 2004-04-29 | @ BOS | 20 | L 3-7 | 7-13 | 4 | 35,441 | Damian Moss | Derek Lowe | Derek Lowe | Damian Moss | | 70 | 97 | -27 |
| 2004-04-30 | vs OAK | 21 | L 2-4 | 7-14 | 4 | 10,226 | Doug Waechter | Mark Redman | Mark Redman | Doug Waechter | | 72 | 101 | -29 |
| 2004-05-01 | vs OAK | 22 | L 5-6 | 7-15 | 5 | 11,109 | Geremi Gonzalez | Rich Harden | Chris Hammond | Lance Carter | | 77 | 107 | -30 |
| 2004-05-02 | vs OAK | 23 | W 8-2 | 8-15 | 4 | 10,177 | Mark Hendrickson | Tim Hudson | Mark Hendrickson | Tim Hudson | | 85 | 109 | -24 |
| 2004-05-03 | @ TEX | 24 | L 0-9 | 8-16 | 4 | 18,116 | Paul Abbott | Kenny Rogers | Kenny Rogers | Paul Abbott | | 85 | 118 | -33 |
| 2004-05-04 | @ TEX | 25 | W 5-4 | 9-16 | 4 | 20,228 | Victor Zambrano | Chan Ho Park | Lance Carter | Jeff Nelson | Danys Baez | 90 | 122 | -32 |
| 2004-05-05 | @ TEX | 26 | L 1-6 | 9-17 | 5 | 21,082 | Doug Waechter | Ryan Drese | Ryan Drese | Doug Waechter | | 91 | 128 | -37 |
| 2004-05-06 | @ ANA | 27 | L 3-7 | 9-18 | 5 | 34,538 | Geremi Gonzalez | Aaron Sele | Aaron Sele | Geremi Gonzalez | Scot Shields | 94 | 135 | -41 |
| 2004-05-07 | @ ANA | 28 | L 0-1 | 9-19 | 5 | 43,674 | Mark Hendrickson | John Lackey | John Lackey | Mark Hendrickson | | 94 | 136 | -42 |
| 2004-05-08 | @ ANA | 29 | L 2-7 | 9-20 | 5 | 43,465 | Paul Abbott | Bartolo Colon | Bartolo Colon | Paul Abbott | | 96 | 143 | -47 |
| 2004-05-09 | @ ANA | 30 | L 4-8 | 9-21 | 5 | 41,410 | Victor Zambrano | Jarrod Washburn | Jarrod Washburn | Victor Zambrano | Francisco Rodriguez | 100 | 151 | -51 |
| 2004-05-11 | vs TEX | 31 | L 4-5 | 9-22 | 5 | 10,389 | Doug Waechter | Ryan Drese | Erasmo Ramirez | Doug Waechter | Francisco Cordero | 104 | 156 | -52 |
| 2004-05-12 | vs TEX | 32 | L 8-9 | 9-23 | 5 | 10,202 | Geremi Gonzalez | Chan Ho Park | Chan Ho Park | John Halama | Francisco Cordero | 112 | 165 | -53 |
| 2004-05-13 | vs TEX | 33 | W 6-3 | 10-23 | 5 | 10,234 | Mark Hendrickson | R.A. Dickey | Mark Hendrickson | R.A. Dickey | Danys Baez | 118 | 168 | -50 |
| 2004-05-14 | @ CLE | 34 | L 7-8 | 10-24 | 5 | 19,796 | Paul Abbott | Jason Davis | Rick White | Lance Carter | | 125 | 176 | -51 |
| 2004-05-15 | @ CLE | 35 | L 7-9 | 10-25 | 5 | 18,040 | Victor Zambrano | Jake Westbrook | Jake Westbrook | Victor Zambrano | | 132 | 185 | -53 |
| 2004-05-16 | @ CLE | 36 | L 0-10 | 10-26 | 5 | 19,499 | Doug Waechter | CC Sabathia | CC Sabathia | Doug Waechter | | 132 | 195 | -63 |
| 2004-05-18 | vs BOS | 37 | L 3-7 | 10-27 | 5 | 12,836 | Mark Hendrickson | Tim Wakefield | Tim Wakefield | Mark Hendrickson | | 135 | 202 | -67 |
| 2004-05-19 | vs BOS | 38 | L 1-4 | 10-28 | 5 | 13,960 | Rob Bell | Curt Schilling | Curt Schilling | Rob Bell | Keith Foulke | 136 | 206 | -70 |
| 2004-05-20 | vs BOS | 39 | W 9-6 | 11-28 | 5 | 12,401 | Victor Zambrano | Derek Lowe | Jorge Sosa | Derek Lowe | Danys Baez | 145 | 212 | -67 |
| 2004-05-21 | vs CLE | 40 | W 5-3 | 12-28 | 5 | 10,213 | Paul Abbott | CC Sabathia | Trever Miller | CC Sabathia | Danys Baez | 150 | 215 | -65 |
| 2004-05-22 | vs CLE | 41 | W 6-3 | 13-28 | 5 | 12,008 | Doug Waechter | Jake Westbrook | Doug Waechter | Jake Westbrook | Jorge Sosa | 156 | 218 | -62 |
| 2004-05-23 | vs CLE | 42 | W 5-4 | 14-28 | 5 | 10,555 | Mark Hendrickson | Cliff Lee | Travis Harper | David Riske | | 161 | 222 | -61 |
| 2004-05-25 | vs MIN | 43 | W 6-1 | 15-28 | 5 | 8,571 | Victor Zambrano | Kyle Lohse | Victor Zambrano | Kyle Lohse | | 167 | 223 | -56 |
| 2004-05-26 | vs MIN | 44 | L 2-4 | 15-29 | 5 | 9,107 | Rob Bell | Seth Greisinger | Seth Greisinger | Rob Bell | Joe Nathan | 169 | 227 | -58 |
| 2004-05-27 | vs MIN | 45 | W 5-4 | 16-29 | 5 | 10,570 | Jason Standridge | Carlos Silva | John Halama | Carlos Silva | Danys Baez | 174 | 231 | -57 |
| 2004-05-28 | vs NYA | 46 | L 5-7 | 16-30 | 5 | 20,627 | Doug Waechter | Javier Vazquez | Javier Vazquez | Doug Waechter | Mariano Rivera | 179 | 238 | -59 |
| 2004-05-29 | vs NYA | 47 | L 3-5 | 16-31 | 5 | 25,692 | Mark Hendrickson | Kevin Brown | Kevin Brown | Mark Hendrickson | Mariano Rivera | 182 | 243 | -61 |
| 2004-05-30 | vs NYA | 48 | W 7-6 | 17-31 | 5 | 26,098 | Victor Zambrano | Jon Lieber | Victor Zambrano | Jon Lieber | Danys Baez | 189 | 249 | -60 |
| 2004-05-31 | @ MIN | 49 | W 7-3 | 18-31 | 5 | 25,191 | Rob Bell | Seth Greisinger | Rob Bell | Seth Greisinger | | 196 | 252 | -56 |
| 2004-06-01 | @ MIN | 50 | L 4-16 | 18-32 | 5 | 13,928 | Paul Abbott | Carlos Silva | Carlos Silva | Paul Abbott | | 200 | 268 | -68 |
| 2004-06-02 | @ MIN | 51 | W 4-2 | 19-32 | 5 | 14,939 | Doug Waechter | Brad Radke | Doug Waechter | Brad Radke | Danys Baez | 204 | 270 | -66 |
| 2004-06-03 | @ MIN | 52 | W 5-2 | 20-32 | 5 | 16,706 | Mark Hendrickson | Johan Santana | Mark Hendrickson | Johan Santana | Danys Baez | 209 | 272 | -63 |
| 2004-06-04 | @ BAL | 53 | W 8-7 | 21-32 | 5 | 32,139 | Victor Zambrano | Erik Bedard | Lance Carter | Mike DeJean | Danys Baez | 217 | 279 | -62 |
| 2004-06-06 | @ BAL | 54 | L 4-5 | 21-33 | 5 | 46,044 | Rob Bell | Rodrigo Lopez | Rodrigo Lopez | Rob Bell | Jorge Julio | 221 | 284 | -63 |
| 2004-06-08 | vs SFN | 55 | L 3-7 | 21-34 | 5 | 13,275 | Doug Waechter | Jerome Williams | Jerome Williams | Doug Waechter | | 224 | 291 | -67 |
| 2004-06-09 | vs SFN | 56 | W 4-3 | 22-34 | 5 | 25,395 | Mark Hendrickson | Jason Schmidt | Danys Baez | Tyler Walker | | 228 | 294 | -66 |
| 2004-06-10 | vs SFN | 57 | W 5-2 | 23-34 | 5 | 10,630 | Victor Zambrano | Kirk Rueter | Victor Zambrano | Kirk Rueter | Jesus Colome | 233 | 296 | -63 |
| 2004-06-11 | vs COL | 58 | W 8-7 | 24-34 | 5 | 9,280 | Chad Gaudin | Aaron Cook | Danys Baez | Shawn Chacon | | 241 | 303 | -62 |
| 2004-06-12 | vs COL | 59 | W 10-7 | 25-34 | 5 | 11,299 | Rob Bell | Shawn Estes | John Halama | Tim Harikkala | | 251 | 310 | -59 |
| 2004-06-13 | vs COL | 60 | W 3-2 | 26-34 | 5 | 11,227 | Dewon Brazelton | Jeff Fassero | Jesus Colome | Shawn Chacon | | 254 | 312 | -58 |
| 2004-06-15 | @ SDN | 61 | W 5-2 | 27-34 | 4 | 28,933 | Mark Hendrickson | Brian Lawrence | Mark Hendrickson | Brian Lawrence | | 259 | 314 | -55 |
| 2004-06-16 | @ SDN | 62 | W 9-6 | 28-34 | 3 | 26,645 | Victor Zambrano | Ismael Valdez | Victor Zambrano | Scott Linebrink | Danys Baez | 268 | 320 | -52 |
| 2004-06-17 | @ SDN | 63 | W 4-1 | 29-34 | 3 | 28,321 | Chad Gaudin | Adam Eaton | Chad Gaudin | Adam Eaton | Danys Baez | 272 | 321 | -49 |
| 2004-06-18 | @ ARI | 64 | W 6-2 | 30-34 | 3 | 27,995 | John Halama | Randy Johnson | John Halama | Randy Johnson | | 278 | 323 | -45 |
| 2004-06-19 | @ ARI | 65 | W 11-4 | 31-34 | 3 | 29,440 | Dewon Brazelton | Lance Cormier | Rob Bell | Lance Cormier | | 289 | 327 | -38 |
| 2004-06-20 | @ ARI | 66 | W 2-1 | 32-34 | 3 | 36,037 | Mark Hendrickson | Brandon Webb | Mark Hendrickson | Brandon Webb | Jesus Colome | 291 | 328 | -37 |
| 2004-06-22 | @ TOR | 67 | W 5-1 | 33-34 | 3 | 15,646 | Chad Gaudin | Pat Hentgen | Travis Harper | Pat Hentgen | | 296 | 329 | -33 |
| 2004-06-23 | @ TOR | 68 | L 1-2 | 33-35 | 3 | 14,713 | Victor Zambrano | Roy Halladay | Jason Frasor | Jesus Colome | | 297 | 331 | -34 |
| 2004-06-24 | @ TOR | 69 | W 19-13 | 34-35 | 3 | 14,876 | John Halama | Ted Lilly | John Halama | Ted Lilly | | 316 | 344 | -28 |
| 2004-06-25 | vs FLO | 70 | W 2-0 | 35-35 | 3 | 25,157 | Dewon Brazelton | A.J. Burnett | Dewon Brazelton | A.J. Burnett | Danys Baez | 318 | 344 | -26 |
| 2004-06-26 | vs FLO | 71 | W 6-4 | 36-35 | 3 | 28,361 | Mark Hendrickson | Michael Tejera | Jorge Sosa | Josias Manzanillo | Danys Baez | 324 | 348 | -24 |
| 2004-06-27 | vs FLO | 72 | L 4-11 | 36-36 | 3 | 23,442 | Chad Gaudin | Carl Pavano | Carl Pavano | Chad Gaudin | | 328 | 359 | -31 |
| 2004-06-28 | vs TOR | 73 | W 10-2 | 37-36 | 3 | 11,218 | Victor Zambrano | Roy Halladay | Victor Zambrano | Roy Halladay | | 338 | 361 | -23 |
| 2004-06-29 | vs TOR | 74 | L 0-4 | 37-37 | 3 | 11,640 | John Halama | Ted Lilly | Ted Lilly | John Halama | | 338 | 365 | -27 |
| 2004-06-30 | vs TOR | 75 | W 6-2 | 38-37 | 3 | 10,560 | Dewon Brazelton | Josh Towers | Dewon Brazelton | Josh Towers | | 344 | 367 | -23 |
| 2004-07-01 | vs TOR | 76 | L 0-14 | 38-38 | 3 | 14,417 | Mark Hendrickson | Miguel Batista | Miguel Batista | Mark Hendrickson | | 344 | 381 | -37 |
| 2004-07-02 | @ FLO | 77 | W 4-2 | 39-38 | 3 | 15,079 | Rob Bell | Carl Pavano | Jesus Colome | Carl Pavano | Danys Baez | 348 | 383 | -35 |
| 2004-07-03 | @ FLO | 78 | W 6-1 | 40-38 | 3 | 30,124 | Victor Zambrano | Brad Penny | Victor Zambrano | Brad Penny | | 354 | 384 | -30 |
| 2004-07-04 | @ FLO | 79 | L 3-4 | 40-39 | 3 | 15,310 | John Halama | A.J. Burnett | A.J. Burnett | John Halama | Armando Benitez | 357 | 388 | -31 |
| 2004-07-05 | @ BAL | 80 | L 2-4 | 40-41 | 3 | 31,438 | Dewon Brazelton | Daniel Cabrera | B.J. Ryan | Dewon Brazelton | Jorge Julio | 359 | 392 | -33 |
| 2004-07-05 | @ BAL | 81 | L 2-8 | 40-41 | 3 | 26,727 | Geremi Gonzalez | Dave Borkowski | Dave Borkowski | Geremi Gonzalez | | 361 | 400 | -39 |
| 2004-07-06 | @ BAL | 82 | W 3-1 | 41-41 | 3 | 22,192 | Mark Hendrickson | Rodrigo Lopez | Mark Hendrickson | Rodrigo Lopez | Danys Baez | 364 | 401 | -37 |
| 2004-07-07 | @ BAL | 83 | W 13-3 | 42-41 | 3 | 28,081 | Rob Bell | John Parrish | Rob Bell | John Parrish | | 377 | 404 | -27 |
| 2004-07-08 | @ NYA | 84 | L 1-7 | 42-42 | 3 | 40,378 | Victor Zambrano | Jose Contreras | Jose Contreras | Victor Zambrano | Mariano Rivera | 378 | 411 | -33 |
| 2004-07-09 | @ NYA | 85 | L 4-5 | 42-43 | 3 | 47,700 | John Halama | Javier Vazquez | Javier Vazquez | Jesus Colome | Mariano Rivera | 382 | 416 | -34 |
| 2004-07-10 | @ NYA | 86 | L 3-6 | 42-44 | 3 | 54,680 | Dewon Brazelton | Jon Lieber | Jon Lieber | Dewon Brazelton | Mariano Rivera | 385 | 422 | -37 |
| 2004-07-11 | @ NYA | 87 | L 3-10 | 42-45 | 3 | 53,383 | Mark Hendrickson | Orlando Hernandez | Orlando Hernandez | Mark Hendrickson | | 388 | 432 | -44 |
| 2004-07-15 | vs BAL | 88 | L 4-5 | 42-46 | 3 | 16,185 | Victor Zambrano | Daniel Cabrera | Daniel Cabrera | Travis Harper | Jorge Julio | 392 | 437 | -45 |
| 2004-07-16 | vs BAL | 89 | W 2-0 | 43-46 | 3 | 20,960 | John Halama | Erik Bedard | John Halama | Erik Bedard | Danys Baez | 394 | 437 | -43 |
| 2004-07-17 | vs BAL | 90 | L 2-3 | 43-47 | 3 | 18,571 | Dewon Brazelton | Rodrigo Lopez | Rodrigo Lopez | Dewon Brazelton | Jorge Julio | 396 | 440 | -44 |
| 2004-07-18 | vs BAL | 91 | W 7-2 | 44-47 | 3 | 13,656 | Mark Hendrickson | Dave Borkowski | Mark Hendrickson | Dave Borkowski | | 403 | 442 | -39 |
| 2004-07-19 | vs NYA | 92 | W 9-7 | 45-47 | 3 | 41,755 | Rob Bell | Alex Graman | Lance Carter | Tanyon Sturtze | Danys Baez | 412 | 449 | -37 |
| 2004-07-20 | vs NYA | 93 | L 2-4 | 45-48 | 3 | 27,613 | Victor Zambrano | Jose Contreras | Jose Contreras | Victor Zambrano | Mariano Rivera | 414 | 453 | -39 |
| 2004-07-21 | @ MIN | 94 | L 2-12 | 45-49 | 3 | 21,095 | John Halama | Brad Radke | Brad Radke | John Halama | | 416 | 465 | -49 |
| 2004-07-22 | @ MIN | 95 | L 5-7 | 45-50 | 3 | 26,454 | Dewon Brazelton | Johan Santana | J.C. Romero | Travis Harper | Joe Nathan | 421 | 472 | -51 |
| 2004-07-23 | @ TOR | 96 | L 4-7 | 45-51 | 3 | 16,633 | Mark Hendrickson | Miguel Batista | Miguel Batista | Mark Hendrickson | Jason Frasor | 425 | 479 | -54 |
| 2004-07-24 | @ TOR | 97 | L 2-4 | 45-52 | 3 | 18,841 | Rob Bell | Josh Towers | Josh Towers | Rob Bell | Jason Frasor | 427 | 483 | -56 |
| 2004-07-25 | @ TOR | 98 | L 3-5 | 45-53 | 3 | 15,784 | Victor Zambrano | David Bush | David Bush | Victor Zambrano | Kerry Ligtenberg | 430 | 488 | -58 |
| 2004-07-27 | vs KCA | 99 | W 6-2 | 46-53 | 3 | 10,854 | Dewon Brazelton | Darrell May | Dewon Brazelton | Darrell May | | 436 | 490 | -54 |
| 2004-07-28 | vs KCA | 100 | W 10-1 | 47-53 | 3 | 10,555 | Mark Hendrickson | Jimmy Gobble | Mark Hendrickson | Jimmy Gobble | | 446 | 491 | -45 |
| 2004-07-29 | vs KCA | 101 | W 2-0 | 48-53 | 3 | 10,084 | Rob Bell | Mike Wood | Rob Bell | Mike Wood | Danys Baez | 448 | 491 | -43 |
| 2004-07-30 | vs TOR | 102 | L 0-3 | 48-54 | 3 | 10,531 | John Halama | Josh Towers | Josh Towers | John Halama | Jason Frasor | 448 | 494 | -46 |
| 2004-07-31 | vs TOR | 103 | W 6-5 | 49-54 | 3 | 17,418 | Jorge Sosa | David Bush | Jorge Sosa | David Bush | Danys Baez | 454 | 499 | -45 |
| 2004-08-01 | vs TOR | 104 | W 5-3 | 50-54 | 3 | 10,750 | Dewon Brazelton | Sean Douglass | Dewon Brazelton | Sean Douglass | Danys Baez | 459 | 502 | -43 |
| 2004-08-02 | vs BOS | 105 | L 3-6 | 50-55 | 3 | 21,835 | Mark Hendrickson | Tim Wakefield | Tim Wakefield | Mark Hendrickson | Keith Foulke | 462 | 508 | -46 |
| 2004-08-03 | vs BOS | 106 | L 2-5 | 50-56 | 3 | 20,882 | Rob Bell | Curt Schilling | Curt Schilling | Rob Bell | | 464 | 513 | -49 |
| 2004-08-04 | vs BOS | 107 | W 5-4 | 51-56 | 3 | 18,133 | John Halama | Bronson Arroyo | Travis Harper | Bronson Arroyo | Danys Baez | 469 | 517 | -48 |
| 2004-08-05 | vs SEA | 108 | L 2-4 | 51-57 | 3 | 10,442 | Jorge Sosa | Bobby Madritsch | Scott Atchison | Danys Baez | | 471 | 521 | -50 |
| 2004-08-06 | vs SEA | 109 | W 2-1 | 52-57 | 3 | 10,452 | Dewon Brazelton | Ryan Franklin | Travis Harper | Clint Nageotte | | 473 | 522 | -49 |
| 2004-08-07 | vs SEA | 110 | L 2-5 | 52-58 | 3 | 21,000 | Mark Hendrickson | Ron Villone | Ron Villone | Mark Hendrickson | J.J. Putz | 475 | 527 | -52 |
| 2004-08-08 | vs SEA | 111 | W 5-1 | 53-58 | 3 | 13,780 | Rob Bell | Jamie Moyer | Rob Bell | Jamie Moyer | Danys Baez | 480 | 528 | -48 |
| 2004-08-09 | @ BOS | 112 | W 8-3 | 54-58 | 3 | 35,172 | John Halama | Curt Schilling | John Halama | Curt Schilling | | 488 | 531 | -43 |
| 2004-08-10 | @ BOS | 113 | L 4-8 | 54-59 | 4 | 35,191 | Jorge Sosa | Bronson Arroyo | Bronson Arroyo | Jorge Sosa | | 492 | 539 | -47 |
| 2004-08-11 | @ BOS | 114 | L 4-14 | 54-60 | 4 | 35,091 | Dewon Brazelton | Derek Lowe | Derek Lowe | Dewon Brazelton | | 496 | 553 | -57 |
| 2004-08-12 | @ BOS | 115 | L 0-6 | 54-61 | 4 | 34,804 | Mark Hendrickson | Pedro Martinez | Pedro Martinez | Mark Hendrickson | | 496 | 559 | -63 |
| 2004-08-13 | @ TEX | 116 | L 3-5 | 54-62 | 4 | 30,266 | Rob Bell | Kenny Rogers | Kenny Rogers | Rob Bell | Francisco Cordero | 499 | 564 | -65 |
| 2004-08-14 | @ TEX | 117 | L 5-6 | 54-63 | 4 | 38,620 | John Halama | Michael Bacsik | Doug Brocail | Franklin Nunez | Francisco Cordero | 504 | 570 | -66 |
| 2004-08-15 | @ TEX | 118 | L 2-6 | 54-64 | 4 | 23,051 | Jorge Sosa | Ryan Drese | Ryan Drese | Jorge Sosa | | 506 | 576 | -70 |
| 2004-08-17 | vs ANA | 119 | W 8-3 | 55-64 | 4 | 9,537 | Dewon Brazelton | Kelvim Escobar | Dewon Brazelton | Kelvim Escobar | | 514 | 579 | -65 |
| 2004-08-18 | vs ANA | 120 | L 4-6 | 55-65 | 4 | 10,731 | Mark Hendrickson | Bartolo Colon | Bartolo Colon | Mark Hendrickson | | 518 | 585 | -67 |
| 2004-08-19 | vs ANA | 121 | L 7-10 | 55-66 | 4 | 9,720 | Rob Bell | John Lackey | John Lackey | Rob Bell | Francisco Rodriguez | 525 | 595 | -70 |
| 2004-08-20 | vs OAK | 122 | L 5-9 | 55-67 | 4 | 10,643 | Jorge Sosa | Rich Harden | Rich Harden | Jorge Sosa | Octavio Dotel | 530 | 604 | -74 |
| 2004-08-21 | vs OAK | 123 | L 0-5 | 55-68 | 4 | 25,123 | John Halama | Barry Zito | Barry Zito | John Halama | | 530 | 609 | -79 |
| 2004-08-22 | vs OAK | 124 | W 2-1 | 56-68 | 4 | 17,599 | Dewon Brazelton | Mark Redman | Dewon Brazelton | Mark Redman | Jesus Colome | 532 | 610 | -78 |
| 2004-08-23 | @ SEA | 125 | W 9-0 | 57-68 | 4 | 34,348 | Scott Kazmir | Bobby Madritsch | Scott Kazmir | Bobby Madritsch | | 541 | 610 | -69 |
| 2004-08-24 | @ SEA | 126 | W 6-5 | 58-68 | 3 | 38,467 | Rob Bell | Ryan Franklin | Rob Bell | Ryan Franklin | | 547 | 615 | -68 |
| 2004-08-25 | @ SEA | 127 | W 6-5 | 59-68 | 3 | 33,495 | Jorge Sosa | Ron Villone | Travis Harper | Scott Atchison | Danys Baez | 553 | 620 | -67 |
| 2004-08-27 | @ OAK | 128 | L 7-8 | 59-69 | 3 | 20,713 | Mark Hendrickson | Mark Redman | Justin Duchscherer | Mark Hendrickson | Octavio Dotel | 560 | 628 | -68 |
| 2004-08-28 | @ OAK | 129 | L 4-5 | 59-70 | 3 | 48,099 | Dewon Brazelton | Tim Hudson | Tim Hudson | Dewon Brazelton | Octavio Dotel | 564 | 633 | -69 |
| 2004-08-29 | @ OAK | 130 | L 6-9 | 59-71 | 3 | 30,538 | Scott Kazmir | Mark Mulder | Octavio Dotel | Danys Baez | | 570 | 642 | -72 |
| 2004-08-31 | vs BAL | 131 | L 6-10 | 59-72 | 4 | 8,620 | Rob Bell | Bruce Chen | Buddy Groom | Lance Carter | | 576 | 652 | -76 |
| 2004-09-01 | vs BAL | 132 | L 0-8 | 59-73 | 4 | 8,988 | Mark Hendrickson | Daniel Cabrera | Daniel Cabrera | Mark Hendrickson | | 576 | 660 | -84 |
| 2004-09-02 | vs BAL | 133 | L 2-13 | 59-74 | 4 | 9,019 | Dewon Brazelton | Erik Bedard | Erik Bedard | Dewon Brazelton | | 578 | 673 | -95 |
| 2004-09-03 | vs DET | 134 | L 2-4 | 59-75 | 4 | 11,631 | Scott Kazmir | Jeremy Bonderman | Jeremy Bonderman | Scott Kazmir | Esteban Yan | 580 | 677 | -97 |
| 2004-09-06 | @ NYA | 135 | L 4-7 | 59-76 | 4 | 44,422 | Doug Waechter | Orlando Hernandez | Orlando Hernandez | Doug Waechter | Paul Quantrill | 584 | 684 | -100 |
| 2004-09-07 | @ NYA | 136 | L 2-11 | 59-77 | 4 | 33,518 | Jorge Sosa | Jon Lieber | Jon Lieber | Jorge Sosa | | 586 | 695 | -109 |
| 2004-09-09 | @ NYA | 137 | L 1-9 | 59-79 | 4 | 0 | Dewon Brazelton | Mike Mussina | Mike Mussina | Dewon Brazelton | | 587 | 704 | -117 |
| 2004-09-09 | @ NYA | 138 | L 5-10 | 59-79 | 4 | 41,230 | Rob Bell | Brad Halsey | Tanyon Sturtze | Rob Bell | | 592 | 714 | -122 |
| 2004-09-10 | @ KCA | 139 | L 5-8 | 59-80 | 4 | 17,746 | Mark Hendrickson | Mike Wood | Dennys Reyes | Franklin Nunez | Jeremy Affeldt | 597 | 722 | -125 |
| 2004-09-11 | @ KCA | 140 | W 8-6 | 60-80 | 4 | 17,496 | Doug Waechter | Jimmy Gobble | Rob Bell | Jimmy Serrano | Danys Baez | 605 | 728 | -123 |
| 2004-09-12 | @ KCA | 141 | W 7-2 | 61-80 | 4 | 14,015 | Jorge Sosa | Denny Bautista | Jorge Sosa | Denny Bautista | | 612 | 730 | -118 |
| 2004-09-14 | @ BOS | 142 | W 5-2 | 62-80 | 4 | 35,118 | Scott Kazmir | Pedro Martinez | Scott Kazmir | Pedro Martinez | Danys Baez | 617 | 732 | -115 |
| 2004-09-15 | @ BOS | 143 | L 6-8 | 62-81 | 4 | 35,105 | Dewon Brazelton | Tim Wakefield | Mike Myers | Franklin Nunez | Keith Foulke | 623 | 740 | -117 |
| 2004-09-16 | @ BOS | 144 | L 4-11 | 62-82 | 4 | 35,048 | Mark Hendrickson | Curt Schilling | Curt Schilling | Mark Hendrickson | | 627 | 751 | -124 |
| 2004-09-17 | @ TOR | 145 | W 11-4 | 63-82 | 4 | 25,987 | Doug Waechter | Josh Towers | Doug Waechter | Josh Towers | | 638 | 755 | -117 |
| 2004-09-18 | @ TOR | 146 | L 2-4 | 63-83 | 4 | 33,432 | Todd Ritchie | David Bush | David Bush | Todd Ritchie | Miguel Batista | 640 | 759 | -119 |
| 2004-09-19 | @ TOR | 147 | L 7-9 | 63-84 | 4 | 30,714 | Scott Kazmir | Justin Miller | Vinnie Chulk | Scott Kazmir | Justin Speier | 647 | 768 | -121 |
| 2004-09-20 | vs KCA | 148 | L 3-6 | 63-85 | 4 | 8,315 | Dewon Brazelton | Brian Anderson | Brian Anderson | Jorge Sosa | Jeremy Affeldt | 650 | 774 | -124 |
| 2004-09-21 | vs KCA | 149 | W 7-4 | 64-85 | 4 | 8,588 | Rob Bell | Zack Greinke | Mark Hendrickson | Shawn Camp | Danys Baez | 657 | 778 | -121 |
| 2004-09-22 | vs KCA | 150 | L 6-7 | 64-86 | 4 | 8,392 | Doug Waechter | Darrell May | Mike MacDougal | Jorge Sosa | Jeremy Affeldt | 663 | 785 | -122 |
| 2004-09-23 | @ NYA | 151 | L 3-7 | 64-87 | 4 | 29,501 | Todd Ritchie | Jon Lieber | Jon Lieber | Todd Ritchie | | 666 | 792 | -126 |
| 2004-09-24 | vs TOR | 152 | W 4-2 | 65-87 | 4 | 13,003 | Mark Hendrickson | Josh Towers | Mark Hendrickson | Josh Towers | Danys Baez | 670 | 794 | -124 |
| 2004-09-25 | vs TOR | 153 | W 6-5 | 66-87 | 4 | 20,978 | Dewon Brazelton | David Bush | Danys Baez | Miguel Batista | | 676 | 799 | -123 |
| 2004-09-27 | vs BOS | 154 | L 3-7 | 66-88 | 4 | 17,602 | Scott Kazmir | Bronson Arroyo | Bronson Arroyo | Jorge Sosa | | 679 | 806 | -127 |
| 2004-09-28 | vs BOS | 155 | L 8-10 | 66-89 | 4 | 20,116 | John Halama | Derek Lowe | Ramiro Mendoza | Danys Baez | Keith Foulke | 687 | 816 | -129 |
| 2004-09-29 | vs BOS | 156 | W 9-4 | 67-89 | 4 | 21,274 | Doug Waechter | Pedro Martinez | Doug Waechter | Pedro Martinez | Trever Miller | 696 | 820 | -124 |
| 2004-09-30 | vs DET | 157 | L 0-8 | 68-90 | 4 | 0 | Dewon Brazelton | Jeremy Bonderman | Jeremy Bonderman | Dewon Brazelton | | 696 | 828 | -132 |
| 2004-09-30 | vs DET | 158 | W 6-4 | 68-90 | 4 | 10,309 | Mark Hendrickson | Wil Ledezma | Travis Harper | Craig Dingman | Danys Baez | 702 | 832 | -130 |
| 2004-10-01 | @ DET | 159 | W 4-1 | 69-90 | 4 | 20,612 | Rob Bell | Mike Maroth | Rob Bell | Mike Maroth | | 706 | 833 | -127 |
| 2004-10-02 | @ DET | 160 | L 1-5 | 69-91 | 4 | 20,029 | Scott Kazmir | Gary Knotts | Gary Knotts | Scott Kazmir | | 707 | 838 | -131 |
| 2004-10-03 | @ DET | 161 | W 7-4 | 70-91 | 4 | 22,471 | John Halama | Nate Robertson | John Halama | Nate Robertson | | 714 | 842 | -128 |