| East | W | L | Pct | GB |
| NY Yankees | 101 | 61 | .623 | -- |
| Boston | 98 | 64 | .605 | 3.0 |
| Baltimore | 78 | 84 | .481 | 23.0 |
| Tampa Bay | 70 | 91 | .435 | 30.5 |
| Toronto | 67 | 94 | .416 | 33.5 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2004-03-30 | Mike Mussina | R | 35 | L 3-8 | @ TBA | 1 | 387 | L | 5.0 | 10 | 5 | 5 | 1 | 2 | 2 | 86 | 30 | 56 | 65% | 0-1 | 9.00 | 2.40 |
| 2004-03-31 | Kevin Brown | R | 39 | W 12-1 | @ TBA | 1 | 442 | W | 7.0 | 6 | 1 | 1 | 0 | 0 | 5 | 79 | 26 | 53 | 67% | 1-0 | 1.29 | 0.86 |
| 2004-04-06 | Mike Mussina | R | 35 | L 4-9 | @ TBA | 2 | 388 | L | 4.0 | 9 | 6 | 6 | 1 | 2 | 1 | 82 | 28 | 54 | 66% | 0-2 | 11.00 | 2.56 |
| 2004-04-07 | Kevin Brown | R | 39 | W 3-2 | @ TBA | 2 | 443 | W | 7.0 | 5 | 1 | 1 | 0 | 0 | 5 | 92 | 29 | 63 | 68% | 2-0 | 1.29 | 0.79 |
| 2004-04-08 | Javier Vazquez | R | 28 | L 3-1 | vs CHA | 1 | 192 | W | 8.0 | 3 | 1 | 1 | 0 | 2 | 5 | 102 | 32 | 70 | 69% | 1-0 | 1.13 | 0.63 |
| 2004-04-09 | Jose Contreras | R | 32 | W 3-9 | vs CHA | 1 | 10 | L | 5.1 | 6 | 5 | 5 | 2 | 3 | 5 | 104 | 47 | 57 | 55% | 0-1 | 9.00 | 1.80 |
| 2004-04-10 | Jorge DePaula | R | 25 | W 3-7 | vs CHA | 1 | 2 | L | 6.1 | 8 | 5 | 5 | 2 | 1 | 1 | 93 | 31 | 62 | 67% | 0-1 | 5.63 | 1.25 |
| 2004-04-11 | Mike Mussina | R | 35 | L 5-4 | vs CHA | 3 | 389 | W | 6.1 | 7 | 4 | 3 | 1 | 2 | 6 | 102 | 37 | 65 | 64% | 1-2 | 8.40 | 2.13 |
| 2004-04-14 | Kevin Brown | R | 39 | L 5-1 | vs TBA | 3 | 444 | W | 7.0 | 5 | 1 | 1 | 0 | 4 | 4 | 100 | 41 | 59 | 59% | 3-0 | 1.29 | 0.95 |
| 2004-04-16 | Javier Vazquez | R | 28 | L 2-6 | @ BOS | 2 | 193 | L | 5.1 | 9 | 6 | 4 | 3 | 1 | 5 | 97 | 36 | 61 | 63% | 1-1 | 3.46 | 1.15 |
| 2004-04-17 | Mike Mussina | R | 35 | L 2-5 | @ BOS | 4 | 390 | L | 5.0 | 7 | 4 | 3 | 1 | 4 | 2 | 99 | 40 | 59 | 60% | 1-3 | 7.65 | 2.15 |
| 2004-04-18 | Jose Contreras | R | 32 | W 7-3 | @ BOS | 2 | 11 | - | 2.1 | 6 | 3 | 3 | 0 | 2 | 3 | 63 | 29 | 34 | 54% | 0-1 | 9.00 | 2.13 |
| 2004-04-19 | Kevin Brown | R | 39 | L 4-5 | @ BOS | 4 | 445 | - | 6.0 | 9 | 4 | 4 | 1 | 0 | 4 | 105 | 34 | 71 | 68% | 3-0 | 2.33 | 1.07 |
| 2004-04-20 | Alex Graman | L | 26 | W 11-8 | @ CHA | 1 | 1 | - | 2.2 | 8 | 5 | 5 | 0 | 2 | 2 | 69 | 28 | 41 | 59% | 0-0 | 15.00 | 3.33 |
| 2004-04-21 | Javier Vazquez | R | 28 | W 3-1 | @ CHA | 3 | 194 | W | 8.0 | 5 | 1 | 1 | 1 | 2 | 6 | 112 | 41 | 71 | 63% | 2-1 | 2.57 | 1.05 |
| 2004-04-22 | Mike Mussina | R | 35 | L 3-4 | @ CHA | 5 | 391 | L | 8.0 | 9 | 4 | 4 | 1 | 3 | 5 | 111 | 40 | 71 | 64% | 1-4 | 6.75 | 1.96 |
| 2004-04-23 | Jose Contreras | R | 32 | W 2-11 | vs BOS | 3 | 12 | L | 3.1 | 5 | 5 | 5 | 2 | 4 | 3 | 90 | 46 | 44 | 49% | 0-2 | 10.64 | 2.36 |
| 2004-04-24 | Kevin Brown | R | 39 | W 2-3 | vs BOS | 5 | 446 | - | 7.0 | 4 | 2 | 1 | 0 | 4 | 1 | 104 | 47 | 57 | 55% | 3-0 | 2.12 | 1.09 |
| 2004-04-25 | Javier Vazquez | R | 28 | W 0-2 | vs BOS | 4 | 195 | L | 6.0 | 4 | 2 | 2 | 1 | 1 | 8 | 102 | 34 | 68 | 67% | 2-2 | 2.67 | 1.00 |
| 2004-04-27 | Mike Mussina | R | 35 | L 10-8 | vs OAK | 6 | 392 | - | 6.0 | 10 | 5 | 4 | 1 | 1 | 7 | 110 | 34 | 76 | 69% | 1-4 | 6.62 | 1.94 |
| 2004-04-28 | Jose Contreras | R | 32 | L 5-1 | vs OAK | 4 | 13 | W | 6.0 | 4 | 1 | 1 | 1 | 1 | 4 | 105 | 41 | 64 | 61% | 1-2 | 7.41 | 1.82 |
| 2004-04-29 | Kevin Brown | R | 39 | L 7-5 | vs OAK | 6 | 447 | W | 6.0 | 7 | 4 | 4 | 1 | 0 | 5 | 113 | 41 | 72 | 64% | 4-0 | 2.70 | 1.10 |
| 2004-04-30 | Javier Vazquez | R | 28 | L 5-2 | vs KCA | 5 | 196 | W | 8.0 | 2 | 2 | 2 | 1 | 0 | 5 | 91 | 26 | 65 | 71% | 3-2 | 2.57 | 0.83 |
| 2004-05-01 | Jon Lieber | R | 34 | L 12-4 | vs KCA | 1 | 226 | W | 7.0 | 5 | 3 | 3 | 1 | 0 | 3 | 91 | 22 | 69 | 76% | 1-0 | 3.86 | 0.71 |
| 2004-05-02 | Mike Mussina | R | 35 | L 4-2 | vs KCA | 7 | 393 | W | 7.0 | 8 | 2 | 2 | 0 | 0 | 2 | 109 | 40 | 69 | 63% | 2-4 | 5.93 | 1.80 |
| 2004-05-04 | Jose Contreras | R | 32 | W 10-8 | @ OAK | 5 | 14 | - | 2.0 | 4 | 7 | 6 | 2 | 4 | 2 | 68 | 32 | 36 | 53% | 1-2 | 9.47 | 2.05 |
| 2004-05-05 | Kevin Brown | R | 39 | W 4-3 | @ OAK | 7 | 448 | - | 6.2 | 7 | 3 | 3 | 1 | 2 | 4 | 109 | 42 | 67 | 61% | 4-0 | 2.87 | 1.13 |
| 2004-05-06 | Javier Vazquez | R | 28 | L 4-7 | @ OAK | 6 | 197 | L | 5.2 | 6 | 7 | 7 | 1 | 4 | 4 | 106 | 37 | 69 | 65% | 3-3 | 3.73 | 0.95 |
| 2004-05-07 | Jon Lieber | R | 34 | L 2-6 | @ SEA | 2 | 227 | L | 6.0 | 9 | 6 | 6 | 1 | 0 | 2 | 92 | 25 | 67 | 73% | 1-1 | 6.23 | 1.08 |
| 2004-05-08 | Mike Mussina | R | 35 | W 6-0 | @ SEA | 8 | 394 | W | 8.0 | 4 | 0 | 0 | 0 | 2 | 7 | 123 | 43 | 80 | 65% | 3-4 | 4.96 | 1.63 |
| 2004-05-09 | Donovan Osborne | L | 35 | W 7-6 | @ SEA | 1 | 139 | - | 1.1 | 6 | 6 | 6 | 1 | 2 | 0 | 43 | 20 | 23 | 53% | 2-0 | 6.92 | 1.69 |
| 2004-05-11 | Kevin Brown | R | 39 | L 8-7 | vs ANA | 8 | 449 | - | 6.0 | 7 | 5 | 5 | 2 | 0 | 2 | 90 | 30 | 60 | 67% | 4-0 | 3.40 | 1.13 |
| 2004-05-12 | Javier Vazquez | R | 28 | W 2-11 | vs ANA | 7 | 198 | L | 7.1 | 6 | 5 | 5 | 2 | 2 | 4 | 100 | 41 | 59 | 59% | 3-4 | 4.13 | 0.98 |
| 2004-05-13 | Jon Lieber | R | 34 | L 7-4 | vs ANA | 3 | 228 | W | 8.0 | 5 | 3 | 3 | 1 | 0 | 6 | 101 | 25 | 76 | 75% | 2-1 | 5.14 | 0.90 |
| 2004-05-14 | Mike Mussina | R | 35 | L 9-5 | vs SEA | 9 | 395 | W | 6.0 | 11 | 5 | 5 | 0 | 1 | 0 | 79 | 26 | 53 | 67% | 4-4 | 5.24 | 1.67 |
| 2004-05-15 | Donovan Osborne | L | 35 | W 7-13 | vs SEA | 2 | 140 | - | 5.0 | 8 | 6 | 4 | 0 | 0 | 0 | 70 | 21 | 49 | 70% | 2-0 | 7.00 | 1.67 |
| 2004-05-16 | Kevin Brown | R | 39 | L 2-1 | vs SEA | 9 | 450 | W | 7.2 | 8 | 1 | 1 | 1 | 1 | 5 | 113 | 37 | 76 | 67% | 5-0 | 3.15 | 1.15 |
| 2004-05-18 | Javier Vazquez | R | 28 | L 0-1 | @ ANA | 8 | 199 | - | 7.0 | 5 | 0 | 0 | 0 | 2 | 5 | 112 | 42 | 70 | 63% | 3-4 | 3.60 | 0.98 |
| 2004-05-19 | Jon Lieber | R | 34 | W 4-2 | @ ANA | 4 | 229 | W | 7.2 | 7 | 2 | 2 | 0 | 1 | 2 | 102 | 39 | 63 | 62% | 3-1 | 4.34 | 0.93 |
| 2004-05-20 | Mike Mussina | R | 35 | W 6-2 | @ ANA | 10 | 396 | W | 7.2 | 7 | 1 | 1 | 0 | 0 | 6 | 118 | 39 | 79 | 67% | 5-4 | 4.71 | 1.57 |
| 2004-05-21 | Kevin Brown | R | 39 | L 7-9 | @ TEX | 10 | 451 | L | 4.2 | 10 | 5 | 5 | 1 | 1 | 2 | 90 | 29 | 61 | 68% | 5-1 | 3.60 | 1.23 |
| 2004-05-22 | Jose Contreras | R | 32 | L 3-4 | @ TEX | 6 | 15 | - | 6.0 | 3 | 1 | 1 | 1 | 2 | 7 | 107 | 46 | 61 | 57% | 1-2 | 7.56 | 1.76 |
| 2004-05-23 | Javier Vazquez | R | 28 | W 8-3 | @ TEX | 9 | 200 | W | 6.0 | 6 | 3 | 3 | 0 | 1 | 6 | 101 | 35 | 66 | 65% | 4-4 | 3.69 | 1.00 |
| 2004-05-25 | Jon Lieber | R | 34 | W 11-3 | @ BAL | 5 | 230 | W | 7.0 | 4 | 2 | 0 | 0 | 1 | 2 | 90 | 36 | 54 | 60% | 4-1 | 3.50 | 0.89 |
| 2004-05-26 | Mike Mussina | R | 35 | W 12-9 | @ BAL | 11 | 397 | - | 5.1 | 6 | 5 | 5 | 1 | 1 | 3 | 97 | 38 | 59 | 61% | 5-4 | 5.03 | 1.56 |
| 2004-05-27 | Jose Contreras | R | 32 | W 18-5 | @ BAL | 7 | 16 | W | 6.0 | 8 | 3 | 3 | 2 | 4 | 4 | 117 | 50 | 67 | 57% | 2-2 | 6.97 | 1.81 |
| 2004-05-28 | Javier Vazquez | R | 28 | W 7-5 | @ TBA | 10 | 201 | W | 6.0 | 8 | 4 | 4 | 1 | 2 | 2 | 101 | 37 | 64 | 63% | 5-4 | 3.90 | 1.06 |
| 2004-05-29 | Kevin Brown | R | 39 | W 5-3 | @ TBA | 11 | 452 | W | 7.2 | 3 | 3 | 3 | 1 | 3 | 5 | 119 | 46 | 73 | 61% | 6-1 | 3.58 | 1.18 |
| 2004-05-30 | Jon Lieber | R | 34 | L 6-7 | @ TBA | 6 | 231 | L | 5.0 | 11 | 6 | 6 | 2 | 1 | 1 | 68 | 16 | 52 | 76% | 4-2 | 4.39 | 1.07 |
| 2004-06-01 | Mike Mussina | R | 35 | L 8-7 | vs BAL | 12 | 398 | W | 6.0 | 9 | 3 | 3 | 0 | 1 | 2 | 104 | 32 | 72 | 69% | 6-4 | 4.99 | 1.57 |
| 2004-06-02 | Jose Contreras | R | 32 | L 6-5 | vs BAL | 8 | 17 | - | 0.2 | 2 | 5 | 1 | 0 | 3 | 0 | 44 | 20 | 24 | 55% | 2-2 | 7.03 | 1.91 |
| 2004-06-03 | Javier Vazquez | R | 28 | L 5-2 | vs BAL | 11 | 202 | W | 7.0 | 5 | 2 | 2 | 1 | 1 | 2 | 117 | 36 | 81 | 69% | 6-4 | 3.77 | 1.04 |
| 2004-06-04 | Kevin Brown | R | 39 | L 7-6 | vs TEX | 12 | 453 | W | 6.0 | 7 | 6 | 5 | 2 | 2 | 4 | 97 | 38 | 59 | 61% | 7-1 | 3.87 | 1.20 |
| 2004-06-05 | Jon Lieber | R | 34 | W 1-8 | vs TEX | 7 | 232 | L | 6.0 | 9 | 6 | 6 | 2 | 0 | 2 | 96 | 35 | 61 | 64% | 4-3 | 4.98 | 1.13 |
| 2004-06-06 | Mike Mussina | R | 35 | L 2-1 | vs TEX | 13 | 399 | W | 8.0 | 4 | 1 | 1 | 0 | 0 | 10 | 98 | 30 | 68 | 69% | 7-4 | 4.61 | 1.46 |
| 2004-06-08 | Javier Vazquez | R | 28 | L 2-1 | vs COL | 12 | 203 | W | 7.0 | 5 | 1 | 1 | 0 | 0 | 6 | 93 | 29 | 64 | 69% | 7-4 | 3.56 | 1.01 |
| 2004-06-09 | Kevin Brown | R | 39 | L 7-5 | vs COL | 13 | 454 | - | 2.0 | 5 | 4 | 3 | 0 | 1 | 2 | 43 | 17 | 26 | 60% | 7-1 | 4.11 | 1.25 |
| 2004-06-10 | Jose Contreras | R | 33 | L 10-4 | vs COL | 9 | 18 | W | 7.0 | 5 | 4 | 4 | 3 | 2 | 6 | 114 | 49 | 65 | 57% | 3-2 | 6.69 | 1.74 |
| 2004-06-11 | Mike Mussina | R | 36 | W 2-10 | vs SDN | 14 | 400 | - | 3.0 | 1 | 1 | 0 | 0 | 0 | 4 | 41 | 12 | 29 | 71% | 7-4 | 4.45 | 1.42 |
| 2004-06-12 | Jon Lieber | R | 34 | L 3-2 | vs SDN | 8 | 233 | W | 6.0 | 11 | 2 | 2 | 0 | 0 | 1 | 67 | 17 | 50 | 75% | 5-3 | 4.75 | 1.21 |
| 2004-06-13 | Javier Vazquez | R | 28 | L 6-5 | vs SDN | 13 | 204 | - | 8.0 | 6 | 2 | 2 | 1 | 0 | 8 | 114 | 36 | 78 | 68% | 7-4 | 3.44 | 0.99 |
| 2004-06-15 | Jose Contreras | R | 33 | W 4-2 | @ ARI | 10 | 19 | W | 6.1 | 5 | 2 | 2 | 1 | 2 | 6 | 124 | 43 | 81 | 65% | 4-2 | 6.20 | 1.67 |
| 2004-06-16 | Tanyon Sturtze | R | 34 | W 9-4 | @ ARI | 1 | 81 | W | 6.0 | 6 | 3 | 3 | 0 | 2 | 3 | 104 | 44 | 60 | 58% | 2-0 | 4.26 | 1.53 |
| 2004-06-17 | Jon Lieber | R | 34 | L 1-6 | @ ARI | 9 | 234 | L | 7.0 | 9 | 4 | 4 | 1 | 1 | 4 | 87 | 29 | 58 | 67% | 5-4 | 4.80 | 1.23 |
| 2004-06-18 | Javier Vazquez | R | 28 | L 3-6 | @ LAN | 14 | 205 | L | 5.0 | 9 | 5 | 2 | 0 | 1 | 5 | 105 | 38 | 67 | 64% | 7-5 | 3.45 | 1.04 |
| 2004-06-19 | Brad Halsey | L | 23 | W 6-2 | @ LAN | 1 | 1 | W | 5.2 | 5 | 2 | 2 | 1 | 1 | 3 | 111 | 40 | 71 | 64% | 1-0 | 3.00 | 1.00 |
| 2004-06-20 | Jose Contreras | R | 33 | L 4-5 | @ LAN | 11 | 20 | L | 6.0 | 7 | 4 | 4 | 1 | 0 | 5 | 100 | 35 | 65 | 65% | 4-3 | 6.18 | 1.61 |
| 2004-06-22 | Mike Mussina | R | 36 | W 10-4 | @ BAL | 15 | 401 | W | 5.0 | 4 | 4 | 4 | 1 | 0 | 1 | 66 | 21 | 45 | 68% | 8-4 | 4.60 | 1.39 |
| 2004-06-23 | Jon Lieber | R | 34 | L 2-13 | @ BAL | 10 | 235 | L | 3.2 | 11 | 7 | 5 | 0 | 0 | 1 | 71 | 21 | 50 | 70% | 5-5 | 5.29 | 1.35 |
| 2004-06-24 | Javier Vazquez | R | 28 | W 5-2 | @ BAL | 15 | 206 | W | 7.0 | 9 | 2 | 2 | 1 | 2 | 2 | 106 | 40 | 66 | 62% | 8-5 | 3.39 | 1.08 |
| 2004-06-26 | Brad Halsey | L | 23 | W 3-9 | vs NYN | 2 | 2 | L | 3.1 | 5 | 7 | 6 | 0 | 5 | 4 | 76 | 33 | 43 | 57% | 1-1 | 8.00 | 1.78 |
| 2004-06-27 | Jose Contreras | R | 33 | L 8-1 | vs NYN | 12 | 21 | W | 6.0 | 2 | 0 | 0 | 0 | 4 | 10 | 96 | 41 | 55 | 57% | 5-3 | 5.53 | 1.54 |
| 2004-06-27 | Mike Mussina | R | 36 | L 11-6 | vs NYN | 16 | 402 | W | 6.0 | 7 | 5 | 4 | 3 | 2 | 6 | 97 | 33 | 64 | 66% | 9-4 | 4.69 | 1.40 |
| 2004-06-29 | Javier Vazquez | R | 28 | L 11-3 | vs BOS | 16 | 207 | W | 6.2 | 7 | 3 | 3 | 3 | 1 | 8 | 115 | 40 | 75 | 65% | 9-5 | 3.42 | 1.08 |
| 2004-06-30 | Jon Lieber | R | 34 | L 4-2 | vs BOS | 11 | 236 | - | 6.0 | 8 | 2 | 2 | 1 | 1 | 3 | 99 | 33 | 66 | 67% | 5-5 | 5.09 | 1.36 |
| 2004-07-01 | Brad Halsey | L | 23 | L 5-4 | vs BOS | 3 | 3 | - | 5.1 | 4 | 2 | 2 | 1 | 2 | 5 | 91 | 36 | 55 | 60% | 1-1 | 6.43 | 1.57 |
| 2004-07-02 | Mike Mussina | R | 36 | L 2-11 | @ NYN | 17 | 403 | L | 5.0 | 9 | 7 | 5 | 2 | 1 | 3 | 73 | 18 | 55 | 75% | 9-5 | 4.90 | 1.43 |
| 2004-07-03 | Jose Contreras | R | 33 | L 9-10 | @ NYN | 13 | 22 | - | 5.0 | 8 | 7 | 7 | 3 | 1 | 4 | 73 | 21 | 52 | 71% | 5-3 | 6.10 | 1.56 |
| 2004-07-04 | Javier Vazquez | R | 28 | L 5-6 | @ NYN | 17 | 208 | - | 5.0 | 6 | 4 | 3 | 1 | 5 | 5 | 113 | 51 | 62 | 55% | 9-5 | 3.50 | 1.13 |
| 2004-07-05 | Jon Lieber | R | 34 | L 10-3 | vs DET | 12 | 237 | W | 6.2 | 6 | 3 | 3 | 0 | 1 | 6 | 108 | 32 | 76 | 70% | 6-5 | 4.97 | 1.33 |
| 2004-07-06 | Mike Mussina | R | 36 | W 1-9 | vs DET | 18 | 404 | L | 6.0 | 9 | 7 | 7 | 2 | 1 | 8 | 105 | 35 | 70 | 67% | 9-6 | 5.21 | 1.44 |
| 2004-07-07 | Brad Halsey | L | 23 | W 8-10 | vs DET | 4 | 4 | L | 4.1 | 9 | 7 | 5 | 1 | 1 | 5 | 86 | 27 | 59 | 69% | 1-2 | 7.11 | 1.68 |
| 2004-07-08 | Jose Contreras | R | 33 | L 7-1 | vs TBA | 14 | 23 | W | 6.2 | 3 | 1 | 1 | 0 | 3 | 3 | 100 | 43 | 57 | 57% | 6-3 | 5.61 | 1.49 |
| 2004-07-09 | Javier Vazquez | R | 28 | L 5-4 | vs TBA | 18 | 209 | W | 5.2 | 4 | 3 | 3 | 2 | 5 | 9 | 108 | 43 | 65 | 60% | 10-5 | 3.55 | 1.15 |
| 2004-07-10 | Jon Lieber | R | 34 | L 6-3 | vs TBA | 13 | 238 | W | 7.0 | 9 | 2 | 2 | 0 | 0 | 5 | 95 | 20 | 75 | 79% | 7-5 | 4.77 | 1.33 |
| 2004-07-11 | Orlando Hernandez | R | 39 | L 10-3 | vs TBA | 1 | 122 | W | 5.0 | 5 | 2 | 2 | 1 | 3 | 5 | 82 | 34 | 48 | 59% | 1-0 | 3.60 | 1.60 |
| 2004-07-15 | Jose Contreras | R | 33 | W 5-1 | @ DET | 15 | 24 | W | 8.0 | 4 | 1 | 1 | 0 | 1 | 7 | 118 | 47 | 71 | 60% | 7-3 | 5.14 | 1.40 |
| 2004-07-16 | Javier Vazquez | R | 28 | L 0-8 | @ DET | 19 | 210 | L | 4.1 | 9 | 8 | 8 | 1 | 0 | 5 | 78 | 24 | 54 | 69% | 10-6 | 4.02 | 1.19 |
| 2004-07-17 | Orlando Hernandez | R | 39 | W 5-3 | @ DET | 2 | 123 | W | 5.0 | 6 | 3 | 3 | 1 | 3 | 6 | 98 | 42 | 56 | 57% | 2-0 | 4.50 | 1.70 |
| 2004-07-18 | Jon Lieber | R | 34 | L 2-4 | @ DET | 14 | 239 | L | 6.2 | 10 | 4 | 4 | 1 | 0 | 5 | 105 | 28 | 77 | 73% | 7-6 | 4.80 | 1.33 |
| 2004-07-19 | Alex Graman | L | 27 | L 7-9 | @ TBA | 2 | 2 | - | 0.1 | 5 | 5 | 5 | 0 | 0 | 0 | 25 | 13 | 12 | 48% | 0-0 | 19.80 | 3.20 |
| 2004-07-20 | Jose Contreras | R | 33 | W 4-2 | @ TBA | 16 | 25 | W | 7.0 | 4 | 2 | 1 | 0 | 2 | 3 | 101 | 44 | 57 | 56% | 8-3 | 4.82 | 1.36 |
| 2004-07-21 | Javier Vazquez | R | 28 | L 10-3 | vs TOR | 20 | 211 | W | 6.0 | 9 | 3 | 3 | 0 | 2 | 4 | 109 | 39 | 70 | 64% | 11-6 | 4.05 | 1.22 |
| 2004-07-22 | Orlando Hernandez | R | 39 | L 1-0 | vs TOR | 3 | 124 | - | 7.0 | 4 | 0 | 0 | 0 | 1 | 10 | 107 | 37 | 70 | 65% | 2-0 | 2.65 | 1.29 |
| 2004-07-23 | Jon Lieber | R | 34 | W 8-7 | @ BOS | 15 | 240 | - | 5.0 | 6 | 4 | 4 | 2 | 1 | 4 | 82 | 24 | 58 | 71% | 7-6 | 4.93 | 1.34 |
| 2004-07-24 | Tanyon Sturtze | R | 34 | L 10-11 | @ BOS | 2 | 82 | - | 3.0 | 2 | 2 | 2 | 0 | 0 | 2 | 45 | 21 | 24 | 53% | 3-2 | 5.08 | 1.44 |
| 2004-07-25 | Jose Contreras | R | 33 | L 6-9 | @ BOS | 17 | 26 | L | 5.1 | 9 | 8 | 8 | 3 | 2 | 3 | 103 | 44 | 59 | 57% | 8-4 | 5.36 | 1.40 |
| 2004-07-26 | Javier Vazquez | R | 28 | W 6-5 | @ TOR | 21 | 212 | - | 6.1 | 5 | 3 | 3 | 2 | 1 | 4 | 97 | 36 | 61 | 63% | 11-6 | 4.07 | 1.21 |
| 2004-07-27 | Orlando Hernandez | R | 39 | W 7-4 | @ TOR | 4 | 125 | - | 2.0 | 0 | 0 | 0 | 0 | 3 | 3 | 52 | 23 | 29 | 56% | 2-0 | 2.37 | 1.32 |
| 2004-07-28 | Jon Lieber | R | 34 | L 2-3 | @ TOR | 16 | 241 | - | 7.2 | 7 | 2 | 2 | 0 | 2 | 4 | 115 | 38 | 77 | 67% | 7-6 | 4.76 | 1.33 |
| 2004-07-29 | Jose Contreras | R | 33 | W 1-9 | vs BAL | 18 | 27 | L | 6.2 | 8 | 7 | 7 | 1 | 2 | 7 | 103 | 38 | 65 | 63% | 8-5 | 5.63 | 1.41 |
| 2004-07-30 | Kevin Brown | R | 39 | L 2-1 | vs BAL | 14 | 455 | W | 6.1 | 4 | 1 | 1 | 1 | 2 | 5 | 88 | 33 | 55 | 63% | 8-1 | 3.93 | 1.23 |
| 2004-07-31 | Javier Vazquez | R | 28 | L 6-4 | vs BAL | 22 | 213 | W | 5.1 | 4 | 4 | 4 | 1 | 2 | 3 | 83 | 29 | 54 | 65% | 12-6 | 4.15 | 1.20 |
| 2004-08-01 | Orlando Hernandez | R | 39 | L 9-7 | vs BAL | 5 | 126 | W | 5.0 | 9 | 3 | 3 | 2 | 1 | 9 | 104 | 35 | 69 | 66% | 3-0 | 3.00 | 1.46 |
| 2004-08-03 | Jon Lieber | R | 34 | W 4-13 | vs OAK | 17 | 242 | L | 4.1 | 11 | 7 | 6 | 1 | 2 | 2 | 89 | 28 | 61 | 69% | 7-7 | 5.05 | 1.39 |
| 2004-08-04 | Esteban Loaiza | R | 33 | L 8-6 | vs OAK | 22 | 258 | - | 6.0 | 6 | 5 | 5 | 2 | 4 | 6 | 111 | 43 | 68 | 61% | 9-5 | 4.96 | 1.44 |
| 2004-08-05 | Kevin Brown | R | 39 | L 5-1 | vs OAK | 15 | 456 | W | 8.0 | 4 | 0 | 0 | 0 | 2 | 7 | 106 | 31 | 75 | 71% | 9-1 | 3.60 | 1.19 |
| 2004-08-06 | Javier Vazquez | R | 28 | L 11-4 | vs TOR | 23 | 214 | W | 8.0 | 6 | 3 | 3 | 1 | 0 | 3 | 92 | 24 | 68 | 74% | 13-6 | 4.11 | 1.17 |
| 2004-08-07 | Orlando Hernandez | R | 39 | L 6-0 | vs TOR | 6 | 127 | W | 8.0 | 5 | 0 | 0 | 0 | 2 | 7 | 103 | 34 | 69 | 67% | 4-0 | 2.25 | 1.31 |
| 2004-08-08 | Jon Lieber | R | 34 | L 8-2 | vs TOR | 18 | 243 | W | 8.0 | 4 | 2 | 2 | 0 | 1 | 5 | 107 | 31 | 76 | 71% | 8-7 | 4.85 | 1.34 |
| 2004-08-09 | Esteban Loaiza | R | 33 | W 4-5 | vs TOR | 23 | 259 | L | 6.0 | 10 | 5 | 4 | 1 | 1 | 2 | 108 | 38 | 70 | 65% | 9-6 | 5.00 | 1.45 |
| 2004-08-10 | Kevin Brown | R | 39 | L 1-7 | @ TEX | 16 | 457 | L | 5.0 | 8 | 5 | 4 | 1 | 2 | 0 | 104 | 45 | 59 | 57% | 9-2 | 3.78 | 1.23 |
| 2004-08-11 | Tanyon Sturtze | R | 34 | W 4-2 | @ TEX | 3 | 83 | W | 5.0 | 5 | 2 | 2 | 0 | 1 | 1 | 88 | 42 | 46 | 52% | 4-2 | 5.06 | 1.46 |
| 2004-08-12 | Orlando Hernandez | R | 39 | W 5-1 | @ TEX | 7 | 128 | W | 7.0 | 4 | 1 | 1 | 0 | 3 | 7 | 107 | 43 | 64 | 60% | 5-0 | 2.08 | 1.26 |
| 2004-08-13 | Jon Lieber | R | 34 | W 11-3 | @ SEA | 19 | 244 | W | 8.0 | 7 | 3 | 3 | 1 | 0 | 4 | 105 | 34 | 71 | 68% | 9-7 | 4.76 | 1.31 |
| 2004-08-14 | Esteban Loaiza | R | 33 | W 6-4 | @ SEA | 24 | 260 | - | 5.1 | 7 | 4 | 4 | 1 | 4 | 3 | 103 | 49 | 54 | 52% | 9-6 | 5.07 | 1.47 |
| 2004-08-15 | Kevin Brown | R | 39 | L 3-7 | @ SEA | 17 | 458 | - | 6.1 | 7 | 3 | 3 | 1 | 2 | 6 | 107 | 38 | 69 | 64% | 9-2 | 3.82 | 1.25 |
| 2004-08-17 | Javier Vazquez | R | 28 | L 2-8 | @ MIN | 24 | 215 | L | 6.2 | 9 | 6 | 6 | 2 | 2 | 2 | 114 | 42 | 72 | 63% | 13-7 | 4.30 | 1.20 |
| 2004-08-18 | Mike Mussina | R | 36 | L 2-7 | @ MIN | 19 | 405 | L | 4.0 | 5 | 4 | 4 | 1 | 2 | 2 | 72 | 34 | 38 | 53% | 9-7 | 5.35 | 1.45 |
| 2004-08-19 | Orlando Hernandez | R | 39 | W 13-10 | @ MIN | 8 | 129 | - | 6.1 | 7 | 5 | 5 | 0 | 3 | 6 | 111 | 48 | 63 | 57% | 5-0 | 2.80 | 1.31 |
| 2004-08-20 | Jon Lieber | R | 34 | W 0-5 | vs ANA | 20 | 245 | L | 6.1 | 11 | 3 | 2 | 1 | 2 | 5 | 103 | 36 | 67 | 65% | 9-8 | 4.67 | 1.35 |
| 2004-08-21 | Esteban Loaiza | R | 33 | W 1-6 | vs ANA | 25 | 261 | L | 3.0 | 7 | 4 | 3 | 2 | 1 | 5 | 65 | 23 | 42 | 65% | 9-7 | 5.14 | 1.50 |
| 2004-08-22 | Kevin Brown | R | 39 | W 3-4 | vs ANA | 18 | 459 | L | 7.0 | 8 | 4 | 4 | 1 | 1 | 3 | 89 | 34 | 55 | 62% | 9-3 | 3.90 | 1.25 |
| 2004-08-23 | Mike Mussina | R | 36 | W 6-4 | @ CLE | 20 | 406 | - | 5.0 | 4 | 3 | 3 | 0 | 3 | 6 | 97 | 37 | 60 | 62% | 9-7 | 5.35 | 1.45 |
| 2004-08-24 | Javier Vazquez | R | 28 | W 5-4 | @ CLE | 25 | 216 | - | 7.0 | 6 | 4 | 4 | 1 | 3 | 4 | 113 | 48 | 65 | 58% | 13-7 | 4.33 | 1.20 |
| 2004-08-25 | Orlando Hernandez | R | 39 | L 3-4 | @ CLE | 9 | 130 | - | 6.0 | 5 | 2 | 2 | 0 | 4 | 2 | 113 | 51 | 62 | 55% | 5-0 | 2.82 | 1.33 |
| 2004-08-26 | Jon Lieber | R | 34 | W 7-4 | @ TOR | 21 | 246 | - | 7.1 | 6 | 4 | 4 | 2 | 2 | 4 | 94 | 33 | 61 | 65% | 9-8 | 4.70 | 1.34 |
| 2004-08-27 | Esteban Loaiza | R | 33 | W 8-7 | @ TOR | 26 | 262 | - | 4.1 | 7 | 4 | 4 | 0 | 3 | 0 | 83 | 35 | 48 | 58% | 9-7 | 5.24 | 1.52 |
| 2004-08-28 | Kevin Brown | R | 39 | W 18-6 | @ TOR | 19 | 460 | W | 7.0 | 6 | 4 | 4 | 0 | 4 | 4 | 121 | 53 | 68 | 56% | 10-3 | 3.98 | 1.26 |
| 2004-08-29 | Mike Mussina | R | 36 | L 4-6 | @ TOR | 21 | 407 | L | 6.1 | 5 | 5 | 5 | 2 | 2 | 7 | 114 | 38 | 76 | 67% | 9-8 | 5.41 | 1.42 |
| 2004-08-31 | Javier Vazquez | R | 28 | W 0-22 | vs CLE | 26 | 217 | L | 1.1 | 5 | 6 | 6 | 0 | 2 | 1 | 41 | 18 | 23 | 56% | 13-8 | 4.61 | 1.23 |
| 2004-09-01 | Orlando Hernandez | R | 39 | L 5-3 | vs CLE | 10 | 131 | W | 7.0 | 3 | 1 | 1 | 0 | 2 | 7 | 101 | 43 | 58 | 57% | 6-0 | 2.64 | 1.26 |
| 2004-09-02 | Jon Lieber | R | 34 | L 9-1 | vs CLE | 22 | 247 | W | 7.0 | 6 | 0 | 0 | 0 | 1 | 3 | 100 | 33 | 67 | 67% | 10-8 | 4.47 | 1.32 |
| 2004-09-03 | Kevin Brown | R | 39 | W 1-3 | vs BAL | 20 | 461 | L | 6.0 | 5 | 3 | 3 | 0 | 2 | 7 | 79 | 31 | 48 | 61% | 10-4 | 4.00 | 1.25 |
| 2004-09-04 | Mike Mussina | R | 36 | W 0-7 | vs BAL | 22 | 408 | L | 7.0 | 7 | 2 | 2 | 1 | 0 | 8 | 119 | 44 | 75 | 63% | 9-9 | 5.26 | 1.40 |
| 2004-09-05 | Javier Vazquez | R | 28 | L 4-3 | vs BAL | 27 | 218 | - | 7.0 | 6 | 3 | 3 | 1 | 3 | 8 | 118 | 46 | 72 | 61% | 13-8 | 4.58 | 1.23 |
| 2004-09-06 | Orlando Hernandez | R | 39 | L 7-4 | vs TBA | 11 | 132 | W | 7.0 | 4 | 2 | 2 | 1 | 1 | 5 | 109 | 42 | 67 | 61% | 7-0 | 2.63 | 1.20 |
| 2004-09-07 | Jon Lieber | R | 34 | L 11-2 | vs TBA | 23 | 248 | W | 6.2 | 9 | 2 | 2 | 1 | 0 | 9 | 105 | 31 | 74 | 70% | 11-8 | 4.38 | 1.32 |
| 2004-09-09 | Mike Mussina | R | 36 | L 9-1 | vs TBA | 23 | 409 | W | 8.0 | 4 | 1 | 1 | 0 | 0 | 6 | 101 | 34 | 67 | 66% | 10-9 | 5.02 | 1.35 |
| 2004-09-09 | Brad Halsey | L | 24 | L 10-5 | vs TBA | 5 | 5 | - | 3.1 | 7 | 3 | 3 | 1 | 1 | 3 | 59 | 19 | 40 | 68% | 1-2 | 7.36 | 1.82 |
| 2004-09-10 | Javier Vazquez | R | 28 | L 8-14 | @ BAL | 28 | 219 | L | 2.1 | 5 | 8 | 8 | 1 | 2 | 3 | 54 | 20 | 34 | 63% | 13-9 | 4.94 | 1.26 |
| 2004-09-11 | Orlando Hernandez | R | 39 | W 5-2 | @ BAL | 12 | 133 | W | 7.0 | 5 | 1 | 1 | 1 | 2 | 4 | 96 | 32 | 64 | 67% | 8-0 | 2.50 | 1.18 |
| 2004-09-12 | Jon Lieber | R | 34 | W 9-7 | @ BAL | 24 | 249 | - | 5.1 | 10 | 6 | 4 | 0 | 0 | 4 | 95 | 25 | 70 | 74% | 11-8 | 4.47 | 1.34 |
| 2004-09-13 | Brad Halsey | L | 24 | L 8-17 | @ KCA | 6 | 6 | L | 4.0 | 6 | 4 | 4 | 0 | 1 | 2 | 82 | 31 | 51 | 62% | 1-3 | 7.62 | 1.81 |
| 2004-09-14 | Mike Mussina | R | 36 | W 4-0 | @ KCA | 24 | 410 | W | 8.0 | 3 | 0 | 0 | 0 | 1 | 11 | 104 | 34 | 70 | 67% | 11-9 | 4.75 | 1.30 |
| 2004-09-15 | Javier Vazquez | R | 28 | W 3-0 | @ KCA | 29 | 220 | W | 7.0 | 3 | 0 | 0 | 0 | 4 | 7 | 109 | 39 | 70 | 64% | 14-9 | 4.75 | 1.25 |
| 2004-09-17 | Orlando Hernandez | R | 39 | W 2-3 | vs BOS | 13 | 134 | - | 3.0 | 3 | 1 | 1 | 1 | 2 | 5 | 68 | 30 | 38 | 56% | 8-0 | 2.52 | 1.20 |
| 2004-09-18 | Jon Lieber | R | 34 | L 14-4 | vs BOS | 25 | 250 | W | 8.1 | 4 | 3 | 3 | 2 | 1 | 7 | 98 | 29 | 69 | 70% | 12-8 | 4.39 | 1.30 |
| 2004-09-19 | Mike Mussina | R | 36 | L 11-1 | vs BOS | 25 | 411 | W | 7.0 | 7 | 1 | 1 | 0 | 2 | 8 | 115 | 35 | 80 | 70% | 12-9 | 4.59 | 1.30 |
| 2004-09-20 | Javier Vazquez | R | 28 | W 3-6 | vs TOR | 30 | 221 | L | 6.2 | 9 | 4 | 4 | 1 | 4 | 3 | 115 | 43 | 72 | 63% | 14-10 | 4.76 | 1.27 |
| 2004-09-21 | Esteban Loaiza | R | 33 | L 5-3 | vs TOR | 27 | 263 | W | 5.1 | 2 | 2 | 2 | 0 | 3 | 5 | 98 | 43 | 55 | 56% | 10-7 | 5.44 | 1.53 |
| 2004-09-22 | Orlando Hernandez | R | 39 | W 4-5 | vs TOR | 14 | 135 | L | 6.1 | 8 | 5 | 5 | 1 | 3 | 6 | 121 | 52 | 69 | 57% | 8-1 | 2.85 | 1.23 |
| 2004-09-23 | Jon Lieber | R | 34 | L 7-3 | vs TBA | 26 | 251 | W | 7.1 | 11 | 3 | 3 | 0 | 0 | 3 | 82 | 21 | 61 | 74% | 13-8 | 4.37 | 1.31 |
| 2004-09-24 | Mike Mussina | R | 36 | W 6-4 | @ BOS | 26 | 412 | - | 6.0 | 5 | 3 | 3 | 2 | 3 | 6 | 103 | 35 | 68 | 66% | 12-9 | 4.58 | 1.30 |
| 2004-09-25 | Javier Vazquez | R | 28 | L 5-12 | @ BOS | 31 | 222 | - | 4.2 | 7 | 5 | 5 | 1 | 2 | 4 | 99 | 38 | 61 | 62% | 14-10 | 4.90 | 1.29 |
| 2004-09-26 | Kevin Brown | R | 40 | L 4-11 | @ BOS | 21 | 462 | L | 0.2 | 6 | 4 | 4 | 0 | 0 | 1 | 31 | 10 | 21 | 68% | 10-5 | 4.25 | 1.29 |
| 2004-09-29 | Mike Mussina | R | 36 | L 5-3 | vs MIN | 27 | 413 | - | 6.0 | 7 | 3 | 3 | 1 | 4 | 3 | 100 | 42 | 58 | 58% | 12-9 | 4.58 | 1.32 |
| 2004-09-29 | Jon Lieber | R | 34 | L 5-4 | vs MIN | 27 | 252 | W | 5.2 | 10 | 4 | 2 | 0 | 0 | 5 | 94 | 25 | 69 | 73% | 14-8 | 4.32 | 1.32 |
| 2004-09-30 | Javier Vazquez | R | 28 | L 6-4 | vs MIN | 32 | 223 | - | 6.2 | 7 | 4 | 4 | 2 | 1 | 4 | 95 | 28 | 67 | 71% | 14-10 | 4.91 | 1.29 |
| 2004-10-01 | Orlando Hernandez | R | 39 | L 0-7 | @ TOR | 15 | 136 | L | 3.0 | 5 | 5 | 5 | 1 | 3 | 2 | 72 | 33 | 39 | 54% | 8-2 | 3.28 | 1.28 |
| 2004-10-02 | Kevin Brown | R | 40 | L 2-4 | @ TOR | 22 | 463 | L | 5.0 | 1 | 1 | 0 | 0 | 2 | 2 | 74 | 33 | 41 | 55% | 10-6 | 4.09 | 1.27 |
| 2004-10-03 | Brad Halsey | L | 24 | W 3-2 | @ TOR | 7 | 7 | - | 5.0 | 5 | 1 | 1 | 0 | 3 | 1 | 89 | 34 | 55 | 62% | 1-3 | 6.47 | 1.72 |