| 2004-04-06 | @ FLO | 1 | L 3-4 | 0-1 | 4 | 55,315 | Livan Hernandez | Josh Beckett | Matt Perisho | Luis Ayala | Armando Benitez | 3 | 4 | -1 |
| 2004-04-07 | @ FLO | 2 | W 3-2 | 1-1 | 3 | 17,622 | Claudio Vargas | Brad Penny | Claudio Vargas | Brad Penny | Rocky Biddle | 6 | 6 | 0 |
| 2004-04-08 | @ FLO | 3 | L 0-3 | 1-2 | 3 | 18,121 | Tomo Ohka | Dontrelle Willis | Dontrelle Willis | Tomo Ohka | Armando Benitez | 6 | 9 | -3 |
| 2004-04-09 | vs NYN | 4 | L 2-3 | 1-3 | 4 | 14,739 | Zach Day | Tyler Yates | David Weathers | Luis Ayala | Orber Moreno | 8 | 12 | -4 |
| 2004-04-10 | vs NYN | 5 | W 1-0 | 2-3 | 3 | 11,957 | John Patterson | Al Leiter | John Patterson | Jae Weong Seo | Rocky Biddle | 9 | 12 | -3 |
| 2004-04-11 | vs NYN | 6 | L 1-4 | 2-4 | 4 | 10,623 | Livan Hernandez | Tom Glavine | Tom Glavine | Livan Hernandez | Braden Looper | 10 | 16 | -6 |
| 2004-04-13 | vs FLO | 7 | L 0-5 | 2-5 | 4 | 14,620 | Claudio Vargas | Brad Penny | Brad Penny | Claudio Vargas | | 10 | 21 | -11 |
| 2004-04-14 | vs FLO | 8 | L 0-9 | 2-6 | 4 | 13,180 | Tomo Ohka | Dontrelle Willis | Dontrelle Willis | Tomo Ohka | | 10 | 30 | -20 |
| 2004-04-15 | vs FLO | 9 | L 0-3 | 2-7 | 5 | 8,494 | Zach Day | Carl Pavano | Carl Pavano | Zach Day | Armando Benitez | 10 | 33 | -23 |
| 2004-04-16 | @ PHI | 10 | L 2-4 | 2-8 | 5 | 39,613 | Livan Hernandez | Eric Milton | Eric Milton | Livan Hernandez | Billy Wagner | 12 | 37 | -25 |
| 2004-04-17 | @ PHI | 11 | L 3-6 | 2-9 | 5 | 42,931 | John Patterson | Kevin Millwood | Kevin Millwood | John Patterson | Billy Wagner | 15 | 43 | -28 |
| 2004-04-18 | @ PHI | 12 | L 4-5 | 2-10 | 5 | 43,791 | Claudio Vargas | Randy Wolf | Billy Wagner | Rocky Biddle | | 19 | 48 | -29 |
| 2004-04-19 | @ NYN | 13 | L 1-4 | 2-11 | 5 | 14,002 | Tomo Ohka | Tyler Yates | Tyler Yates | Tomo Ohka | Braden Looper | 20 | 52 | -32 |
| 2004-04-20 | @ NYN | 14 | W 2-1 | 3-11 | 5 | 14,513 | Zach Day | Al Leiter | Zach Day | David Weathers | Rocky Biddle | 22 | 53 | -31 |
| 2004-04-21 | @ NYN | 15 | W 2-1 | 4-11 | 5 | 23,565 | Livan Hernandez | Tom Glavine | Livan Hernandez | Tom Glavine | Rocky Biddle | 24 | 54 | -30 |
| 2004-04-22 | @ NYN | 16 | L 2-3 | 4-12 | 5 | 15,062 | John Patterson | Steve Trachsel | Steve Trachsel | Chad Bentz | Braden Looper | 26 | 57 | -31 |
| 2004-04-23 | vs PHI | 17 | L 6-8 | 4-13 | 5 | 30,112 | Claudio Vargas | Kevin Millwood | Kevin Millwood | Chad Bentz | Billy Wagner | 32 | 65 | -33 |
| 2004-04-24 | vs PHI | 18 | L 0-7 | 4-14 | 5 | 6,899 | Tomo Ohka | Randy Wolf | Randy Wolf | Tomo Ohka | | 32 | 72 | -40 |
| 2004-04-25 | vs PHI | 19 | W 2-0 | 5-14 | 5 | 8,267 | Zach Day | Vicente Padilla | Zach Day | Vicente Padilla | Rocky Biddle | 34 | 72 | -38 |
| 2004-04-26 | @ SDN | 20 | L 2-3 | 5-15 | 5 | 25,438 | Livan Hernandez | Jake Peavy | Akinori Otsuka | Luis Ayala | | 36 | 75 | -39 |
| 2004-04-27 | @ SDN | 21 | L 0-3 | 5-16 | 5 | 25,473 | John Patterson | Ismael Valdez | Ismael Valdez | John Patterson | Trevor Hoffman | 36 | 78 | -42 |
| 2004-04-28 | @ SDN | 22 | L 4-5 | 5-17 | 5 | 24,079 | Claudio Vargas | Adam Eaton | Antonio Osuna | Luis Ayala | Trevor Hoffman | 40 | 83 | -43 |
| 2004-04-29 | @ SDN | 23 | L 1-2 | 5-18 | 5 | 24,581 | Tomo Ohka | David Wells | David Wells | Tomo Ohka | Trevor Hoffman | 41 | 85 | -44 |
| 2004-04-30 | @ LAN | 24 | L 4-13 | 5-19 | 5 | 54,958 | Zach Day | Kazuhisa Ishii | Kazuhisa Ishii | Zach Day | | 45 | 98 | -53 |
| 2004-05-01 | @ LAN | 25 | L 4-5 | 5-20 | 5 | 52,900 | Livan Hernandez | Jose Lima | Guillermo Mota | Luis Ayala | Eric Gagne | 49 | 103 | -54 |
| 2004-05-02 | @ LAN | 26 | W 6-4 | 6-20 | 5 | 35,351 | Sun-Woo Kim | Hideo Nomo | Sun-Woo Kim | Hideo Nomo | | 55 | 107 | -52 |
| 2004-05-04 | vs COL | 27 | W 10-4 | 7-20 | 5 | 4,001 | Claudio Vargas | Jason Jennings | Claudio Vargas | Jason Jennings | | 65 | 111 | -46 |
| 2004-05-05 | vs COL | 28 | L 0-2 | 7-21 | 5 | 3,609 | Zach Day | Joe Kennedy | Joe Kennedy | Zach Day | Shawn Chacon | 65 | 113 | -48 |
| 2004-05-06 | vs COL | 29 | W 3-1 | 8-21 | 5 | 8,851 | Livan Hernandez | Scott Elarton | Livan Hernandez | Scott Elarton | | 68 | 114 | -46 |
| 2004-05-07 | vs SLN | 30 | W 4-2 | 9-21 | 5 | 5,332 | Sun-Woo Kim | Matt Morris | Sun-Woo Kim | Matt Morris | Rocky Biddle | 72 | 116 | -44 |
| 2004-05-08 | vs SLN | 31 | W 2-0 | 10-21 | 5 | 5,611 | Tomo Ohka | Jason Marquis | Tomo Ohka | Jason Marquis | Rocky Biddle | 74 | 116 | -42 |
| 2004-05-09 | vs SLN | 32 | L 2-5 | 10-22 | 5 | 12,301 | Claudio Vargas | Chris Carpenter | Chris Carpenter | Claudio Vargas | Jason Isringhausen | 76 | 121 | -45 |
| 2004-05-11 | @ MIL | 33 | L 5-8 | 10-23 | 5 | 10,761 | Livan Hernandez | Ben Sheets | Dave Burba | T.J. Tucker | | 81 | 129 | -48 |
| 2004-05-12 | @ MIL | 34 | L 3-4 | 10-24 | 5 | 10,803 | Zach Day | Wes Obermueller | Wes Obermueller | Zach Day | Danny Kolb | 84 | 133 | -49 |
| 2004-05-13 | @ MIL | 35 | L 4-7 | 10-25 | 5 | 14,972 | Sun-Woo Kim | Doug Davis | Doug Davis | Sun-Woo Kim | Danny Kolb | 88 | 140 | -52 |
| 2004-05-14 | @ ARI | 36 | W 4-3 | 11-25 | 5 | 27,118 | Tomo Ohka | Casey Fossum | Chad Cordero | Jose Valverde | Rocky Biddle | 92 | 143 | -51 |
| 2004-05-15 | @ ARI | 37 | W 5-0 | 12-25 | 5 | 32,379 | Claudio Vargas | Casey Daigle | Claudio Vargas | Casey Daigle | | 97 | 143 | -46 |
| 2004-05-16 | @ ARI | 38 | W 6-1 | 13-25 | 5 | 32,629 | Livan Hernandez | Steve Sparks | Livan Hernandez | Steve Sparks | | 103 | 144 | -41 |
| 2004-05-18 | vs MIL | 39 | W 3-2 | 14-25 | 5 | 8,387 | Zach Day | Doug Davis | Zach Day | Doug Davis | Rocky Biddle | 106 | 146 | -40 |
| 2004-05-19 | vs MIL | 40 | L 3-6 | 14-26 | 5 | 8,157 | Sun-Woo Kim | Victor Santos | Victor Santos | Sun-Woo Kim | Danny Kolb | 109 | 152 | -43 |
| 2004-05-20 | vs MIL | 41 | L 2-3 | 14-27 | 5 | 8,941 | Tomo Ohka | Matt Wise | Mike Adams | Rocky Biddle | Danny Kolb | 111 | 155 | -44 |
| 2004-05-21 | vs SFN | 42 | L 5-6 | 14-28 | 5 | 14,325 | Livan Hernandez | Brett Tomko | Wayne Franklin | Livan Hernandez | Matt Herges | 116 | 161 | -45 |
| 2004-05-22 | vs SFN | 43 | L 2-7 | 14-29 | 5 | 16,836 | Claudio Vargas | Jerome Williams | Tyler Walker | Jeremy Fikac | | 118 | 168 | -50 |
| 2004-05-24 | vs ATL | 44 | L 0-5 | 14-30 | 5 | 4,675 | Zach Day | John Thomson | John Thomson | Zach Day | | 118 | 173 | -55 |
| 2004-05-25 | vs ATL | 45 | W 3-1 | 15-30 | 5 | 4,235 | Tomo Ohka | Horacio Ramirez | Tomo Ohka | Horacio Ramirez | Rocky Biddle | 121 | 174 | -53 |
| 2004-05-26 | vs ATL | 46 | L 1-6 | 15-31 | 5 | 4,544 | Livan Hernandez | Russ Ortiz | Russ Ortiz | Livan Hernandez | | 122 | 180 | -58 |
| 2004-05-28 | vs CIN | 47 | L 6-7 | 15-32 | 5 | 7,058 | Claudio Vargas | Cory Lidle | Cory Lidle | Claudio Vargas | Danny Graves | 128 | 187 | -59 |
| 2004-05-29 | vs CIN | 48 | L 1-4 | 15-33 | 5 | 7,913 | Zach Day | Jose Acevedo | Jose Acevedo | Zach Day | Danny Graves | 129 | 191 | -62 |
| 2004-05-30 | vs CIN | 49 | W 6-2 | 16-33 | 5 | 9,745 | Tomo Ohka | Joe Valentine | Tomo Ohka | Joe Valentine | Chad Cordero | 135 | 193 | -58 |
| 2004-05-31 | @ ATL | 50 | L 2-8 | 16-34 | 5 | 24,945 | Livan Hernandez | Russ Ortiz | Russ Ortiz | Livan Hernandez | | 137 | 201 | -64 |
| 2004-06-01 | @ ATL | 51 | L 6-7 | 16-35 | 5 | 20,271 | Tony Armas | Jaret Wright | Armando Almanza | Rocky Biddle | | 143 | 208 | -65 |
| 2004-06-02 | @ ATL | 52 | W 8-4 | 17-35 | 5 | 21,055 | Claudio Vargas | Mike Hampton | Claudio Vargas | Mike Hampton | | 151 | 212 | -61 |
| 2004-06-04 | @ CIN | 53 | W 4-2 | 18-35 | 5 | 32,701 | Zach Day | Jose Acevedo | Zach Day | Jose Acevedo | Rocky Biddle | 155 | 214 | -59 |
| 2004-06-05 | @ CIN | 54 | L 3-6 | 18-36 | 5 | 40,545 | Tomo Ohka | Paul Wilson | Todd Jones | Chad Cordero | | 158 | 220 | -62 |
| 2004-06-06 | @ CIN | 55 | L 5-6 | 18-37 | 5 | 31,814 | Livan Hernandez | Todd Van Poppel | Mike Matthews | Rocky Biddle | | 163 | 226 | -63 |
| 2004-06-08 | @ KCA | 56 | L 2-4 | 18-38 | 5 | 15,209 | Tony Armas | Zack Greinke | Zack Greinke | Tony Armas | Jeremy Affeldt | 165 | 230 | -65 |
| 2004-06-10 | @ KCA | 57 | W 8-0 | 20-38 | 5 | 0 | Zach Day | Dennys Reyes | Zach Day | Dennys Reyes | | 173 | 230 | -57 |
| 2004-06-10 | @ KCA | 58 | W 7-2 | 20-38 | 5 | 16,891 | Tomo Ohka | Jimmy Gobble | Sun-Woo Kim | Jimmy Gobble | | 180 | 232 | -52 |
| 2004-06-11 | @ SEA | 59 | L 0-1 | 20-39 | 5 | 32,826 | Livan Hernandez | Ryan Franklin | Eddie Guardado | Livan Hernandez | | 180 | 233 | -53 |
| 2004-06-12 | @ SEA | 60 | L 0-3 | 20-40 | 5 | 36,562 | Claudio Vargas | Jamie Moyer | Jamie Moyer | Claudio Vargas | Eddie Guardado | 180 | 236 | -56 |
| 2004-06-13 | @ SEA | 61 | L 1-8 | 20-41 | 5 | 43,339 | Tony Armas | Joel Pineiro | Joel Pineiro | Tony Armas | | 181 | 244 | -63 |
| 2004-06-15 | vs MIN | 62 | L 2-8 | 20-42 | 5 | 4,557 | Zach Day | Johan Santana | Johan Santana | Zach Day | | 183 | 252 | -69 |
| 2004-06-16 | vs MIN | 63 | L 4-5 | 20-43 | 5 | 3,763 | Sun-Woo Kim | Kyle Lohse | Juan Rincon | Jeremy Fikac | Joe Nathan | 187 | 257 | -70 |
| 2004-06-17 | vs MIN | 64 | L 4-6 | 20-44 | 5 | 10,044 | Livan Hernandez | Matt Guerrier | Aaron Fultz | Livan Hernandez | Joe Nathan | 191 | 263 | -72 |
| 2004-06-18 | vs CHA | 65 | L 7-11 | 20-45 | 5 | 4,576 | Claudio Vargas | Mark Buehrle | Neal Cotts | Luis Ayala | Damaso Marte | 198 | 274 | -76 |
| 2004-06-19 | vs CHA | 66 | W 17-14 | 21-45 | 5 | 18,414 | Tony Armas | Arnie Munoz | Jeremy Fikac | Arnie Munoz | Chad Cordero | 215 | 288 | -73 |
| 2004-06-20 | vs CHA | 67 | W 4-2 | 22-45 | 5 | 6,546 | Zach Day | Jon Garland | Chad Cordero | Jon Garland | | 219 | 290 | -71 |
| 2004-06-22 | vs PHI | 68 | W 5-2 | 23-45 | 5 | 4,564 | Livan Hernandez | Brett Myers | Livan Hernandez | Brett Myers | Chad Cordero | 224 | 292 | -68 |
| 2004-06-23 | vs PHI | 69 | L 2-5 | 23-46 | 5 | 4,209 | Sun-Woo Kim | Kevin Millwood | Kevin Millwood | Sun-Woo Kim | Billy Wagner | 226 | 297 | -71 |
| 2004-06-24 | vs PHI | 70 | W 3-2 | 24-46 | 5 | 11,655 | Tony Armas | Eric Milton | Tony Armas | Eric Milton | Chad Cordero | 229 | 299 | -70 |
| 2004-06-25 | @ TOR | 71 | L 1-3 | 24-47 | 5 | 16,484 | Zach Day | Josh Towers | Josh Towers | Zach Day | Jason Frasor | 230 | 302 | -72 |
| 2004-06-26 | @ TOR | 72 | L 5-10 | 24-48 | 5 | 23,875 | Scott Downs | Miguel Batista | Miguel Batista | Scott Downs | | 235 | 312 | -77 |
| 2004-06-27 | @ TOR | 73 | W 9-4 | 25-48 | 5 | 25,915 | Livan Hernandez | Pat Hentgen | Livan Hernandez | Pat Hentgen | | 244 | 316 | -72 |
| 2004-06-28 | @ PHI | 74 | L 6-14 | 25-49 | 5 | 39,444 | Sun-Woo Kim | Kevin Millwood | Kevin Millwood | Sun-Woo Kim | | 250 | 330 | -80 |
| 2004-06-29 | @ PHI | 75 | L 7-17 | 25-50 | 5 | 35,390 | Shawn Hill | Eric Milton | Eric Milton | Shawn Hill | | 257 | 347 | -90 |
| 2004-06-30 | @ PHI | 76 | W 6-3 | 26-50 | 5 | 40,407 | Zach Day | Paul Abbott | Joe Horgan | Tim Worrell | Chad Cordero | 263 | 350 | -87 |
| 2004-07-01 | @ PHI | 77 | L 5-10 | 26-51 | 5 | 43,246 | Scott Downs | Randy Wolf | Randy Wolf | Scott Downs | | 268 | 360 | -92 |
| 2004-07-02 | vs TOR | 78 | W 2-0 | 27-51 | 5 | 8,220 | Livan Hernandez | David Bush | Livan Hernandez | David Bush | | 270 | 360 | -90 |
| 2004-07-03 | vs TOR | 79 | L 0-2 | 27-52 | 5 | 8,831 | Tony Armas | Roy Halladay | Roy Halladay | Tony Armas | Jason Frasor | 270 | 362 | -92 |
| 2004-07-04 | vs TOR | 80 | W 6-4 | 28-52 | 5 | 8,279 | Shawn Hill | Ted Lilly | Shawn Hill | Ted Lilly | Joe Horgan | 276 | 366 | -90 |
| 2004-07-05 | vs ATL | 81 | L 4-11 | 28-53 | 5 | 13,122 | Zach Day | Paul Byrd | Paul Byrd | Zach Day | | 280 | 377 | -97 |
| 2004-07-06 | vs ATL | 82 | L 0-1 | 28-54 | 5 | 7,697 | Scott Downs | Russ Ortiz | Russ Ortiz | Scott Downs | John Smoltz | 280 | 378 | -98 |
| 2004-07-07 | vs ATL | 83 | L 2-14 | 28-55 | 5 | 8,534 | Livan Hernandez | Jaret Wright | Jaret Wright | Livan Hernandez | | 282 | 392 | -110 |
| 2004-07-08 | vs PIT | 84 | W 2-1 | 29-55 | 5 | 7,746 | Tony Armas | Kris Benson | Luis Ayala | John Grabow | Chad Cordero | 284 | 393 | -109 |
| 2004-07-09 | vs PIT | 85 | L 0-11 | 29-56 | 5 | 7,436 | Shawn Hill | Sean Burnett | Sean Burnett | Shawn Hill | | 284 | 404 | -120 |
| 2004-07-10 | vs PIT | 86 | W 4-0 | 30-56 | 5 | 8,780 | Rocky Biddle | Kip Wells | Rocky Biddle | Kip Wells | | 288 | 404 | -116 |
| 2004-07-11 | vs PIT | 87 | W 2-1 | 31-56 | 5 | 8,101 | Scott Downs | Josh Fogg | Scott Downs | Josh Fogg | Chad Cordero | 290 | 405 | -115 |
| 2004-07-15 | @ ATL | 88 | L 0-8 | 31-57 | 5 | 33,883 | Livan Hernandez | Jaret Wright | Jaret Wright | Livan Hernandez | | 290 | 413 | -123 |
| 2004-07-16 | @ ATL | 89 | W 5-1 | 32-57 | 5 | 26,424 | John Patterson | Paul Byrd | Joe Horgan | Paul Byrd | | 295 | 414 | -119 |
| 2004-07-17 | @ ATL | 90 | L 2-6 | 32-58 | 5 | 34,296 | Tony Armas | Russ Ortiz | Russ Ortiz | Chad Bentz | John Smoltz | 297 | 420 | -123 |
| 2004-07-18 | @ ATL | 91 | L 5-16 | 32-59 | 5 | 23,952 | Scott Downs | John Thomson | John Thomson | Scott Downs | | 302 | 436 | -134 |
| 2004-07-19 | @ PIT | 92 | W 6-2 | 33-59 | 5 | 14,787 | Rocky Biddle | Josh Fogg | Joe Horgan | John Grabow | | 308 | 438 | -130 |
| 2004-07-20 | @ PIT | 93 | L 1-2 | 33-60 | 5 | 18,075 | Livan Hernandez | Sean Burnett | Sean Burnett | Livan Hernandez | Jose Mesa | 309 | 440 | -131 |
| 2004-07-21 | @ NYN | 94 | L 4-5 | 33-61 | 5 | 30,227 | John Patterson | Jae Weong Seo | Orber Moreno | Joe Horgan | Braden Looper | 313 | 445 | -132 |
| 2004-07-22 | @ NYN | 95 | W 4-1 | 34-61 | 5 | 27,637 | Zach Day | Tom Glavine | Luis Ayala | John Franco | Chad Cordero | 317 | 446 | -129 |
| 2004-07-23 | vs FLO | 96 | W 2-1 | 35-61 | 5 | 6,407 | Tony Armas | Brad Penny | Tony Armas | Brad Penny | Chad Cordero | 319 | 447 | -128 |
| 2004-07-24 | vs FLO | 97 | W 6-2 | 36-61 | 5 | 7,229 | Rocky Biddle | Dontrelle Willis | Rocky Biddle | Dontrelle Willis | | 325 | 449 | -124 |
| 2004-07-25 | vs FLO | 98 | W 6-4 | 37-61 | 5 | 9,688 | Livan Hernandez | Justin Wayne | Livan Hernandez | Justin Wayne | Luis Ayala | 331 | 453 | -122 |
| 2004-07-26 | vs NYN | 99 | W 19-10 | 38-61 | 5 | 6,643 | John Patterson | Scott Erickson | Luis Ayala | Scott Erickson | | 350 | 463 | -113 |
| 2004-07-27 | vs NYN | 100 | L 2-4 | 38-62 | 5 | 7,147 | Zach Day | Tom Glavine | Tom Glavine | Zach Day | Braden Looper | 352 | 467 | -115 |
| 2004-07-28 | vs NYN | 101 | W 7-4 | 39-62 | 5 | 6,852 | Tony Armas | Jae Weong Seo | T.J. Tucker | Jae Weong Seo | Chad Cordero | 359 | 471 | -112 |
| 2004-07-29 | vs NYN | 102 | L 1-10 | 39-63 | 5 | 20,042 | Rocky Biddle | Al Leiter | Al Leiter | Rocky Biddle | | 360 | 481 | -121 |
| 2004-07-30 | @ FLO | 103 | W 9-0 | 40-63 | 5 | 16,441 | Livan Hernandez | Josh Beckett | Livan Hernandez | Josh Beckett | | 369 | 481 | -112 |
| 2004-07-31 | @ FLO | 104 | W 8-5 | 41-63 | 5 | 21,562 | John Patterson | A.J. Burnett | Rocky Biddle | Josias Manzanillo | Chad Cordero | 377 | 486 | -109 |
| 2004-08-03 | @ SLN | 105 | W 10-6 | 42-63 | 5 | 33,696 | Sun-Woo Kim | Jason Marquis | Chad Cordero | Dan Haren | | 387 | 492 | -105 |
| 2004-08-04 | @ SLN | 106 | L 4-5 | 42-64 | 5 | 35,779 | Livan Hernandez | Jeff Suppan | Julian Tavarez | Chad Cordero | | 391 | 497 | -106 |
| 2004-08-05 | @ SLN | 107 | L 1-2 | 42-65 | 5 | 31,961 | John Patterson | Chris Carpenter | Chris Carpenter | Luis Ayala | Jason Isringhausen | 392 | 499 | -107 |
| 2004-08-06 | @ HOU | 108 | L 0-4 | 42-66 | 5 | 35,921 | Rocky Biddle | Roy Oswalt | Roy Oswalt | Rocky Biddle | | 392 | 503 | -111 |
| 2004-08-07 | @ HOU | 109 | W 8-3 | 43-66 | 5 | 39,840 | Jon Rauch | Andy Pettitte | Jon Rauch | David Weathers | | 400 | 506 | -106 |
| 2004-08-08 | @ HOU | 110 | W 5-2 | 44-66 | 5 | 38,407 | Sun-Woo Kim | Roger Clemens | T.J. Tucker | Roger Clemens | | 405 | 508 | -103 |
| 2004-08-10 | vs ARI | 111 | W 4-0 | 45-66 | 5 | 8,386 | Livan Hernandez | Randy Johnson | Livan Hernandez | Randy Johnson | | 409 | 508 | -99 |
| 2004-08-11 | vs ARI | 112 | W 7-3 | 46-66 | 5 | 5,089 | John Patterson | Brandon Webb | John Patterson | Brandon Webb | | 416 | 511 | -95 |
| 2004-08-12 | vs ARI | 113 | W 7-5 | 47-66 | 5 | 14,639 | Rocky Biddle | Lance Cormier | Luis Ayala | Lance Cormier | Chad Cordero | 423 | 516 | -93 |
| 2004-08-13 | vs HOU | 114 | W 6-5 | 48-66 | 5 | 8,593 | Jon Rauch | Roger Clemens | Claudio Vargas | Chad Harville | | 429 | 521 | -92 |
| 2004-08-14 | vs HOU | 115 | W 8-3 | 49-66 | 5 | 11,929 | Tony Armas | Carlos Hernandez | T.J. Tucker | Carlos Hernandez | | 437 | 524 | -87 |
| 2004-08-15 | vs HOU | 116 | L 4-5 | 49-67 | 5 | 13,528 | Livan Hernandez | Peter Munro | Dan Miceli | Luis Ayala | Brad Lidge | 441 | 529 | -88 |
| 2004-08-16 | @ SFN | 117 | L 5-8 | 49-68 | 5 | 39,545 | John Patterson | Kirk Rueter | Jason Christiansen | Chad Cordero | Dustin Hermanson | 446 | 537 | -91 |
| 2004-08-17 | @ SFN | 118 | L 4-5 | 49-69 | 5 | 39,511 | Sun-Woo Kim | Jason Schmidt | Dustin Hermanson | Luis Ayala | | 450 | 542 | -92 |
| 2004-08-18 | @ SFN | 119 | W 6-2 | 50-70 | 5 | 0 | Rocky Biddle | Brad Hennessey | Rocky Biddle | Brad Hennessey | | 456 | 544 | -88 |
| 2004-08-18 | @ SFN | 120 | L 4-14 | 50-70 | 5 | 42,296 | T.J. Tucker | Wayne Franklin | Wayne Franklin | T.J. Tucker | | 460 | 558 | -98 |
| 2004-08-20 | @ COL | 121 | W 4-3 | 51-70 | 5 | 32,707 | Tony Armas | Jamey Wright | Luis Ayala | Brian Fuentes | Chad Cordero | 464 | 561 | -97 |
| 2004-08-21 | @ COL | 122 | L 2-5 | 51-71 | 5 | 33,225 | Livan Hernandez | Joe Kennedy | Joe Kennedy | Livan Hernandez | | 466 | 566 | -100 |
| 2004-08-22 | @ COL | 123 | W 8-2 | 52-71 | 5 | 26,833 | John Patterson | Jason Jennings | John Patterson | Jason Jennings | | 474 | 568 | -94 |
| 2004-08-23 | vs LAN | 124 | W 8-7 | 53-71 | 5 | 8,639 | Sun-Woo Kim | Odalis Perez | Chad Cordero | Giovanni Carrara | | 482 | 575 | -93 |
| 2004-08-24 | vs LAN | 125 | L 2-10 | 53-72 | 5 | 8,109 | Rocky Biddle | Kazuhisa Ishii | Kazuhisa Ishii | Rocky Biddle | | 484 | 585 | -101 |
| 2004-08-25 | vs LAN | 126 | W 6-3 | 54-72 | 5 | 7,570 | Tony Armas | Jose Lima | Joe Horgan | Jose Lima | Luis Ayala | 490 | 588 | -98 |
| 2004-08-26 | vs LAN | 127 | L 3-10 | 54-73 | 5 | 18,520 | Livan Hernandez | Jeff Weaver | Jeff Weaver | Livan Hernandez | | 493 | 598 | -105 |
| 2004-08-27 | vs SDN | 128 | W 10-3 | 55-73 | 5 | 8,165 | Scott Downs | Dennis Tankersley | Scott Downs | Dennis Tankersley | | 503 | 601 | -98 |
| 2004-08-28 | vs SDN | 129 | L 2-5 | 55-74 | 5 | 15,450 | John Patterson | Jake Peavy | Jake Peavy | John Patterson | Trevor Hoffman | 505 | 606 | -101 |
| 2004-08-29 | vs SDN | 130 | L 3-11 | 55-75 | 5 | 12,181 | Sun-Woo Kim | David Wells | David Wells | Sun-Woo Kim | | 508 | 617 | -109 |
| 2004-08-30 | vs CHN | 131 | L 2-5 | 55-76 | 5 | 8,122 | Rocky Biddle | Greg Maddux | Greg Maddux | Rocky Biddle | LaTroy Hawkins | 510 | 622 | -112 |
| 2004-08-31 | vs CHN | 132 | W 8-0 | 56-76 | 5 | 7,162 | Livan Hernandez | Mark Prior | Livan Hernandez | Mark Prior | | 518 | 622 | -104 |
| 2004-09-01 | vs CHN | 133 | L 1-2 | 56-77 | 5 | 5,837 | Tony Armas | Kerry Wood | LaTroy Hawkins | Claudio Vargas | | 519 | 624 | -105 |
| 2004-09-03 | vs ATL | 134 | L 1-7 | 56-78 | 5 | 8,617 | Scott Downs | Paul Byrd | Paul Byrd | Scott Downs | | 520 | 631 | -111 |
| 2004-09-04 | vs ATL | 135 | L 0-9 | 56-79 | 5 | 9,772 | John Patterson | Russ Ortiz | Russ Ortiz | John Patterson | | 520 | 640 | -120 |
| 2004-09-05 | vs ATL | 136 | W 4-3 | 57-79 | 5 | 10,015 | Livan Hernandez | John Thomson | T.J. Tucker | Juan Cruz | | 524 | 643 | -119 |
| 2004-09-06 | @ CHN | 137 | L 1-9 | 57-80 | 5 | 38,807 | Tony Armas | Carlos Zambrano | Carlos Zambrano | Tony Armas | | 525 | 652 | -127 |
| 2004-09-07 | @ CHN | 138 | W 7-6 | 58-80 | 5 | 38,321 | Sun-Woo Kim | Matt Clement | Chad Cordero | Todd Wellemeyer | Joe Horgan | 532 | 658 | -126 |
| 2004-09-08 | @ CHN | 139 | W 6-0 | 59-80 | 5 | 38,379 | Scott Downs | Greg Maddux | Scott Downs | Greg Maddux | | 538 | 658 | -120 |
| 2004-09-10 | @ ATL | 140 | L 3-4 | 59-81 | 5 | 22,086 | John Patterson | John Thomson | John Thomson | John Patterson | John Smoltz | 541 | 662 | -121 |
| 2004-09-11 | @ ATL | 141 | L 1-8 | 59-82 | 5 | 28,860 | Livan Hernandez | Mike Hampton | Juan Cruz | Livan Hernandez | | 542 | 670 | -128 |
| 2004-09-12 | @ ATL | 142 | L 8-9 | 59-83 | 5 | 25,865 | Tony Armas | Jose Capellan | Juan Cruz | Luis Ayala | | 550 | 679 | -129 |
| 2004-09-13 | @ FLO | 143 | L 3-6 | 59-84 | 5 | 4,003 | Sun-Woo Kim | Josh Beckett | Matt Perisho | Gary Majewski | | 553 | 685 | -132 |
| 2004-09-14 | @ FLO | 144 | L 6-8 | 59-85 | 5 | 5,457 | Scott Downs | Ismael Valdez | Rudy Seanez | Luis Ayala | Guillermo Mota | 559 | 693 | -134 |
| 2004-09-15 | @ FLO | 145 | W 6-2 | 61-85 | 5 | 0 | John Patterson | Carl Pavano | John Patterson | Carl Pavano | | 565 | 695 | -130 |
| 2004-09-15 | @ FLO | 146 | W 10-4 | 61-85 | 5 | 12,608 | Tomo Ohka | Nate Bump | Jon Rauch | Nate Bump | | 575 | 699 | -124 |
| 2004-09-16 | @ FLO | 147 | L 3-4 | 61-86 | 5 | 17,219 | Livan Hernandez | Dontrelle Willis | Dontrelle Willis | Livan Hernandez | Armando Benitez | 578 | 703 | -125 |
| 2004-09-17 | @ PHI | 148 | W 12-8 | 62-86 | 5 | 35,498 | Claudio Vargas | Eric Milton | Luis Ayala | Tim Worrell | | 590 | 711 | -121 |
| 2004-09-18 | @ PHI | 149 | W 6-5 | 63-86 | 5 | 38,650 | Sun-Woo Kim | Vicente Padilla | Chad Cordero | Brett Myers | Francis Beltran | 596 | 716 | -120 |
| 2004-09-19 | @ PHI | 150 | L 2-7 | 63-87 | 5 | 42,603 | Scott Downs | Kevin Millwood | Gavin Floyd | Scott Downs | | 598 | 723 | -125 |
| 2004-09-21 | vs NYN | 151 | W 6-1 | 64-87 | 5 | 3,839 | Livan Hernandez | Al Leiter | Livan Hernandez | Al Leiter | | 604 | 724 | -120 |
| 2004-09-22 | vs NYN | 152 | L 2-3 | 64-88 | 5 | 3,664 | John Patterson | Steve Trachsel | Bartolome Fortunato | Luis Ayala | Braden Looper | 606 | 727 | -121 |
| 2004-09-23 | vs NYN | 153 | L 2-4 | 64-89 | 5 | 11,142 | Tomo Ohka | Tom Glavine | Tom Glavine | Tomo Ohka | Braden Looper | 608 | 731 | -123 |
| 2004-09-24 | vs PHI | 154 | W 8-1 | 65-89 | 5 | 5,481 | Sun-Woo Kim | Brett Myers | Sun-Woo Kim | Brett Myers | | 616 | 732 | -116 |
| 2004-09-25 | vs PHI | 155 | L 3-4 | 65-90 | 5 | 8,491 | Scott Downs | Kevin Millwood | Tim Worrell | Joey Eischen | Billy Wagner | 619 | 736 | -117 |
| 2004-09-26 | vs PHI | 156 | L 1-2 | 65-91 | 5 | 12,382 | Livan Hernandez | Cory Lidle | Cory Lidle | Livan Hernandez | Billy Wagner | 620 | 738 | -118 |
| 2004-09-27 | vs FLO | 157 | L 1-4 | 65-92 | 5 | 3,923 | John Patterson | Josh Beckett | Josh Beckett | John Patterson | Armando Benitez | 621 | 742 | -121 |
| 2004-09-28 | vs FLO | 158 | L 2-5 | 65-93 | 5 | 5,416 | Tomo Ohka | Ismael Valdez | Ismael Valdez | Tomo Ohka | Armando Benitez | 623 | 747 | -124 |
| 2004-09-29 | vs FLO | 159 | L 1-9 | 65-94 | 5 | 31,395 | Sun-Woo Kim | Carl Pavano | Carl Pavano | Sun-Woo Kim | | 624 | 756 | -132 |
| 2004-10-01 | @ NYN | 160 | W 4-2 | 66-94 | 5 | 29,273 | Scott Downs | Kris Benson | Jon Rauch | Pedro Feliciano | Chad Cordero | 628 | 758 | -130 |
| 2004-10-02 | @ NYN | 161 | W 6-3 | 67-94 | 5 | 30,147 | Livan Hernandez | Al Leiter | Chad Cordero | Braden Looper | Gary Majewski | 634 | 761 | -127 |
| 2004-10-03 | @ NYN | 162 | L 1-8 | 67-95 | 5 | 33,569 | John Patterson | Tom Glavine | Tom Glavine | John Patterson | | 635 | 769 | -134 |