| Central | W | L | Pct | GB |
| Minnesota | 92 | 70 | .568 | -- |
| Chi White Sox | 83 | 79 | .512 | 9.0 |
| Cleveland | 80 | 82 | .494 | 12.0 |
| Detroit | 72 | 90 | .444 | 20.0 |
| KC Royals | 58 | 104 | .358 | 34.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2004-04-05 | Brad Radke | R | 31 | L 7-4 | vs CLE | 1 | 285 | - | 6.0 | 11 | 4 | 2 | 3 | 0 | 3 | 85 | 27 | 58 | 68% | 0-0 | 3.00 | 1.83 |
| 2004-04-06 | Johan Santana | L | 25 | L 7-6 | vs CLE | 1 | 42 | - | 4.0 | 4 | 2 | 2 | 0 | 0 | 1 | 60 | 18 | 42 | 70% | 0-0 | 4.50 | 1.00 |
| 2004-04-07 | Kyle Lohse | R | 26 | W 4-11 | vs CLE | 1 | 81 | L | 4.0 | 9 | 5 | 5 | 1 | 3 | 4 | 88 | 38 | 50 | 57% | 0-1 | 11.25 | 3.00 |
| 2004-04-08 | Carlos Silva | R | 25 | L 6-10 | @ DET | 1 | 2 | - | 6.0 | 8 | 4 | 4 | 1 | 1 | 4 | 86 | 34 | 52 | 60% | 0-0 | 6.00 | 1.50 |
| 2004-04-10 | Brad Radke | R | 31 | W 10-5 | @ DET | 2 | 286 | W | 5.0 | 9 | 5 | 5 | 1 | 1 | 6 | 101 | 35 | 66 | 65% | 1-0 | 5.73 | 1.91 |
| 2004-04-11 | Johan Santana | L | 25 | L 5-6 | @ DET | 2 | 43 | - | 5.0 | 5 | 3 | 3 | 1 | 1 | 3 | 94 | 34 | 60 | 64% | 0-0 | 5.00 | 1.11 |
| 2004-04-12 | Kyle Lohse | R | 26 | L 3-6 | @ CLE | 2 | 82 | L | 6.0 | 7 | 5 | 5 | 1 | 2 | 2 | 103 | 41 | 62 | 60% | 0-2 | 9.00 | 2.10 |
| 2004-04-14 | Carlos Silva | R | 25 | W 10-6 | @ CLE | 2 | 3 | W | 5.0 | 7 | 3 | 3 | 0 | 2 | 1 | 83 | 34 | 49 | 59% | 1-0 | 5.73 | 1.64 |
| 2004-04-15 | Brad Radke | R | 31 | W 3-0 | @ CLE | 3 | 287 | W | 8.0 | 4 | 0 | 0 | 0 | 1 | 5 | 111 | 40 | 71 | 64% | 2-0 | 3.32 | 1.37 |
| 2004-04-16 | Johan Santana | L | 25 | L 9-7 | vs KCA | 3 | 44 | - | 6.1 | 6 | 6 | 6 | 3 | 1 | 6 | 94 | 35 | 59 | 63% | 0-0 | 6.60 | 1.13 |
| 2004-04-17 | Kyle Lohse | R | 26 | L 8-4 | vs KCA | 3 | 83 | W | 6.0 | 6 | 4 | 4 | 2 | 4 | 5 | 102 | 47 | 55 | 54% | 1-2 | 7.88 | 1.94 |
| 2004-04-18 | Seth Greisinger | R | 29 | L 8-3 | vs KCA | 1 | 30 | - | 4.0 | 6 | 3 | 2 | 1 | 1 | 4 | 78 | 24 | 54 | 69% | 0-0 | 10.29 | 2.00 |
| 2004-04-20 | Carlos Silva | R | 25 | L 6-4 | vs DET | 3 | 4 | W | 6.0 | 6 | 4 | 4 | 1 | 2 | 1 | 93 | 36 | 57 | 61% | 2-0 | 5.82 | 1.53 |
| 2004-04-21 | Brad Radke | R | 31 | W 8-11 | vs DET | 4 | 288 | L | 2.0 | 7 | 6 | 6 | 0 | 0 | 1 | 28 | 7 | 21 | 75% | 2-1 | 5.57 | 1.57 |
| 2004-04-22 | Johan Santana | L | 25 | L 4-3 | vs DET | 4 | 45 | W | 6.0 | 7 | 3 | 3 | 1 | 3 | 6 | 99 | 33 | 66 | 67% | 1-0 | 6.00 | 1.29 |
| 2004-04-23 | Kyle Lohse | R | 26 | W 7-5 | @ KCA | 4 | 84 | - | 5.2 | 9 | 5 | 5 | 0 | 3 | 2 | 103 | 39 | 64 | 62% | 1-2 | 7.77 | 1.95 |
| 2004-04-24 | Seth Greisinger | R | 29 | L 1-10 | @ KCA | 2 | 31 | L | 4.2 | 7 | 3 | 3 | 1 | 0 | 4 | 93 | 36 | 57 | 61% | 0-1 | 9.00 | 1.91 |
| 2004-04-25 | Carlos Silva | R | 25 | W 4-2 | @ KCA | 4 | 5 | W | 7.0 | 9 | 1 | 1 | 0 | 0 | 2 | 106 | 38 | 68 | 64% | 3-0 | 4.50 | 1.46 |
| 2004-04-26 | Brad Radke | R | 31 | W 1-6 | vs TOR | 5 | 289 | L | 7.0 | 10 | 4 | 4 | 0 | 0 | 3 | 97 | 29 | 68 | 70% | 2-2 | 5.46 | 1.54 |
| 2004-04-27 | Johan Santana | L | 25 | L 7-4 | vs TOR | 5 | 46 | - | 7.0 | 8 | 4 | 3 | 0 | 2 | 8 | 108 | 39 | 69 | 64% | 1-0 | 5.46 | 1.32 |
| 2004-04-28 | Kyle Lohse | R | 26 | L 9-5 | vs TOR | 5 | 85 | - | 6.0 | 7 | 1 | 1 | 0 | 2 | 1 | 98 | 37 | 61 | 62% | 1-2 | 6.43 | 1.86 |
| 2004-04-30 | Carlos Silva | R | 25 | L 6-3 | vs ANA | 5 | 6 | W | 7.1 | 7 | 3 | 2 | 0 | 2 | 3 | 101 | 37 | 64 | 63% | 4-0 | 4.06 | 1.42 |
| 2004-05-01 | Brad Radke | R | 32 | W 0-1 | vs ANA | 6 | 290 | - | 7.0 | 5 | 0 | 0 | 0 | 2 | 4 | 96 | 36 | 60 | 63% | 2-2 | 4.37 | 1.43 |
| 2004-05-02 | Johan Santana | L | 25 | W 1-3 | vs ANA | 6 | 47 | - | 7.0 | 5 | 1 | 1 | 0 | 2 | 6 | 98 | 31 | 67 | 68% | 1-0 | 4.63 | 1.26 |
| 2004-05-04 | Kyle Lohse | R | 26 | L 3-4 | @ SEA | 6 | 86 | - | 5.2 | 7 | 3 | 3 | 1 | 3 | 4 | 101 | 44 | 57 | 56% | 1-2 | 6.27 | 1.88 |
| 2004-05-05 | Carlos Silva | R | 25 | W 5-1 | @ SEA | 6 | 7 | W | 8.0 | 5 | 1 | 1 | 0 | 1 | 5 | 107 | 41 | 66 | 62% | 5-0 | 3.46 | 1.28 |
| 2004-05-06 | Brad Radke | R | 32 | L 1-2 | @ SEA | 7 | 291 | - | 6.0 | 4 | 1 | 1 | 0 | 0 | 3 | 100 | 33 | 67 | 67% | 2-2 | 3.95 | 1.32 |
| 2004-05-07 | Johan Santana | L | 25 | L 9-11 | @ OAK | 7 | 48 | - | 4.0 | 7 | 5 | 5 | 3 | 1 | 5 | 83 | 31 | 52 | 63% | 1-0 | 5.31 | 1.33 |
| 2004-05-08 | Seth Greisinger | R | 29 | W 3-2 | @ OAK | 3 | 32 | - | 5.0 | 6 | 2 | 2 | 1 | 2 | 2 | 92 | 33 | 59 | 64% | 0-2 | 7.00 | 1.78 |
| 2004-05-09 | Kyle Lohse | R | 26 | L 4-8 | @ OAK | 7 | 87 | L | 4.1 | 6 | 5 | 4 | 1 | 6 | 1 | 111 | 55 | 56 | 50% | 1-3 | 6.39 | 1.95 |
| 2004-05-11 | Carlos Silva | R | 25 | L 7-6 | vs SEA | 7 | 8 | - | 7.0 | 11 | 2 | 1 | 0 | 0 | 4 | 103 | 29 | 74 | 72% | 5-0 | 3.13 | 1.33 |
| 2004-05-12 | Brad Radke | R | 32 | L 4-3 | vs SEA | 8 | 292 | W | 8.0 | 10 | 3 | 3 | 1 | 1 | 4 | 112 | 32 | 80 | 71% | 3-2 | 3.86 | 1.33 |
| 2004-05-13 | Johan Santana | L | 25 | L 1-0 | vs SEA | 8 | 49 | W | 7.0 | 6 | 0 | 0 | 0 | 2 | 5 | 94 | 32 | 62 | 66% | 2-0 | 4.50 | 1.30 |
| 2004-05-14 | Kyle Lohse | R | 26 | W 3-2 | @ CHA | 8 | 88 | - | 6.1 | 5 | 2 | 2 | 1 | 2 | 1 | 97 | 37 | 60 | 62% | 1-3 | 5.93 | 1.84 |
| 2004-05-15 | Seth Greisinger | R | 29 | W 4-1 | @ CHA | 4 | 33 | W | 7.0 | 4 | 1 | 1 | 1 | 1 | 2 | 82 | 34 | 48 | 59% | 1-2 | 5.40 | 1.48 |
| 2004-05-16 | Carlos Silva | R | 25 | L 0-11 | @ CHA | 8 | 9 | L | 3.0 | 8 | 6 | 6 | 2 | 1 | 2 | 61 | 18 | 43 | 70% | 5-1 | 4.04 | 1.43 |
| 2004-05-17 | Brad Radke | R | 32 | W 9-5 | @ TOR | 9 | 293 | - | 6.0 | 8 | 4 | 4 | 0 | 0 | 6 | 102 | 32 | 70 | 69% | 3-2 | 4.09 | 1.33 |
| 2004-05-18 | Johan Santana | L | 25 | L 3-5 | @ TOR | 9 | 50 | L | 5.1 | 8 | 5 | 4 | 0 | 2 | 6 | 108 | 43 | 65 | 60% | 2-1 | 4.67 | 1.35 |
| 2004-05-19 | Kyle Lohse | R | 26 | W 6-5 | @ TOR | 9 | 89 | - | 6.1 | 6 | 5 | 5 | 0 | 4 | 3 | 100 | 45 | 55 | 55% | 1-3 | 6.12 | 1.82 |
| 2004-05-20 | Seth Greisinger | R | 29 | W 3-10 | vs CHA | 5 | 34 | L | 4.0 | 10 | 7 | 3 | 1 | 2 | 1 | 70 | 22 | 48 | 69% | 1-3 | 5.59 | 1.69 |
| 2004-05-21 | Carlos Silva | R | 25 | W 2-8 | vs CHA | 9 | 10 | L | 4.0 | 10 | 6 | 4 | 1 | 0 | 2 | 86 | 25 | 61 | 71% | 5-2 | 4.42 | 1.51 |
| 2004-05-22 | Brad Radke | R | 32 | L 9-1 | vs CHA | 10 | 294 | W | 7.0 | 6 | 1 | 1 | 0 | 0 | 5 | 105 | 33 | 72 | 69% | 4-2 | 3.77 | 1.27 |
| 2004-05-23 | Johan Santana | L | 25 | W 7-17 | vs CHA | 10 | 51 | L | 3.0 | 10 | 7 | 7 | 2 | 2 | 2 | 73 | 26 | 47 | 64% | 2-2 | 5.56 | 1.49 |
| 2004-05-25 | Kyle Lohse | R | 26 | L 1-6 | @ TBA | 10 | 90 | L | 6.0 | 7 | 4 | 4 | 1 | 2 | 2 | 103 | 34 | 69 | 67% | 1-4 | 6.11 | 1.79 |
| 2004-05-26 | Seth Greisinger | R | 29 | W 4-2 | @ TBA | 6 | 35 | W | 5.0 | 6 | 2 | 2 | 0 | 2 | 3 | 91 | 39 | 52 | 57% | 2-3 | 5.29 | 1.68 |
| 2004-05-27 | Carlos Silva | R | 25 | L 4-5 | @ TBA | 10 | 11 | L | 6.0 | 11 | 5 | 4 | 1 | 0 | 1 | 86 | 30 | 56 | 65% | 5-3 | 4.58 | 1.54 |
| 2004-05-28 | Brad Radke | R | 32 | L 1-2 | @ KCA | 11 | 295 | - | 7.0 | 7 | 1 | 1 | 0 | 0 | 4 | 109 | 34 | 75 | 69% | 4-2 | 3.52 | 1.25 |
| 2004-05-29 | Johan Santana | L | 25 | L 2-5 | @ KCA | 11 | 52 | L | 6.1 | 6 | 4 | 4 | 1 | 2 | 6 | 103 | 36 | 67 | 65% | 2-3 | 5.61 | 1.48 |
| 2004-05-30 | Kyle Lohse | R | 26 | W 8-3 | @ KCA | 11 | 91 | W | 5.0 | 9 | 3 | 2 | 1 | 2 | 4 | 92 | 34 | 58 | 63% | 2-4 | 5.90 | 1.82 |
| 2004-05-31 | Seth Greisinger | R | 29 | W 3-7 | vs TBA | 7 | 36 | L | 5.2 | 5 | 5 | 5 | 2 | 2 | 4 | 84 | 32 | 52 | 62% | 2-4 | 5.63 | 1.60 |
| 2004-06-01 | Carlos Silva | R | 25 | L 16-4 | vs TBA | 11 | 12 | W | 7.0 | 5 | 2 | 2 | 1 | 2 | 1 | 75 | 30 | 45 | 60% | 6-3 | 4.36 | 1.48 |
| 2004-06-02 | Brad Radke | R | 32 | W 2-4 | vs TBA | 12 | 296 | L | 7.0 | 9 | 3 | 3 | 0 | 1 | 3 | 99 | 32 | 67 | 68% | 4-3 | 3.55 | 1.26 |
| 2004-06-03 | Johan Santana | L | 25 | W 2-5 | vs TBA | 12 | 53 | L | 7.2 | 4 | 4 | 4 | 1 | 4 | 7 | 114 | 49 | 65 | 57% | 2-4 | 5.48 | 1.42 |
| 2004-06-04 | Kyle Lohse | R | 26 | L 3-2 | vs DET | 12 | 92 | - | 6.0 | 6 | 2 | 2 | 1 | 2 | 5 | 112 | 45 | 67 | 60% | 2-4 | 5.64 | 1.78 |
| 2004-06-05 | Seth Greisinger | R | 29 | W 0-6 | vs DET | 8 | 37 | L | 5.1 | 8 | 4 | 4 | 2 | 1 | 5 | 91 | 39 | 52 | 57% | 2-5 | 5.80 | 1.62 |
| 2004-06-06 | Carlos Silva | R | 25 | L 6-5 | vs DET | 12 | 13 | - | 7.2 | 9 | 3 | 3 | 0 | 1 | 2 | 89 | 30 | 59 | 66% | 6-3 | 4.26 | 1.46 |
| 2004-06-08 | Brad Radke | R | 32 | L 2-1 | vs NYN | 13 | 297 | - | 7.0 | 5 | 1 | 1 | 0 | 2 | 7 | 105 | 33 | 72 | 69% | 4-3 | 3.36 | 1.24 |
| 2004-06-09 | Johan Santana | L | 25 | L 5-3 | vs NYN | 13 | 54 | W | 7.0 | 6 | 1 | 1 | 1 | 0 | 10 | 111 | 29 | 82 | 74% | 3-4 | 5.09 | 1.37 |
| 2004-06-10 | Kyle Lohse | R | 26 | L 3-2 | vs NYN | 13 | 93 | - | 7.0 | 5 | 2 | 2 | 1 | 1 | 3 | 97 | 32 | 65 | 67% | 2-4 | 5.35 | 1.69 |
| 2004-06-11 | Seth Greisinger | R | 29 | W 6-11 | vs PHI | 9 | 38 | - | 5.2 | 9 | 6 | 6 | 2 | 1 | 3 | 79 | 26 | 53 | 67% | 2-5 | 6.18 | 1.63 |
| 2004-06-12 | Carlos Silva | R | 25 | L 6-1 | vs PHI | 13 | 14 | W | 7.0 | 8 | 1 | 1 | 1 | 0 | 8 | 86 | 27 | 59 | 69% | 7-3 | 4.00 | 1.43 |
| 2004-06-13 | Brad Radke | R | 32 | W 1-2 | vs PHI | 14 | 298 | - | 7.0 | 6 | 1 | 1 | 0 | 1 | 7 | 113 | 40 | 73 | 65% | 4-3 | 3.20 | 1.22 |
| 2004-06-15 | Johan Santana | L | 25 | W 8-2 | @ MON | 14 | 55 | W | 8.0 | 3 | 2 | 2 | 1 | 0 | 7 | 98 | 23 | 75 | 77% | 4-4 | 4.82 | 1.27 |
| 2004-06-16 | Kyle Lohse | R | 26 | W 5-4 | @ MON | 14 | 94 | - | 6.0 | 6 | 4 | 4 | 1 | 0 | 3 | 88 | 27 | 61 | 69% | 2-4 | 5.40 | 1.64 |
| 2004-06-17 | Matt Guerrier | R | 26 | W 6-4 | @ MON | 1 | 1 | - | 4.0 | 6 | 3 | 2 | 1 | 1 | 3 | 77 | 24 | 53 | 69% | 0-0 | 4.50 | 1.75 |
| 2004-06-18 | Carlos Silva | R | 25 | L 1-4 | @ MIL | 14 | 15 | L | 4.0 | 8 | 3 | 3 | 1 | 2 | 1 | 81 | 36 | 45 | 56% | 7-4 | 4.13 | 1.48 |
| 2004-06-19 | Brad Radke | R | 32 | L 6-7 | @ MIL | 15 | 299 | - | 6.2 | 7 | 5 | 2 | 0 | 0 | 5 | 85 | 28 | 57 | 67% | 4-3 | 3.15 | 1.21 |
| 2004-06-20 | Johan Santana | L | 25 | W 4-2 | @ MIL | 15 | 56 | W | 8.0 | 4 | 1 | 2 | 1 | 2 | 12 | 115 | 42 | 73 | 63% | 5-4 | 4.60 | 1.23 |
| 2004-06-22 | Kyle Lohse | R | 26 | L 2-9 | @ BOS | 15 | 95 | L | 6.0 | 7 | 3 | 3 | 2 | 1 | 3 | 106 | 39 | 67 | 63% | 2-5 | 5.34 | 1.62 |
| 2004-06-23 | Carlos Silva | R | 25 | W 4-2 | @ BOS | 15 | 16 | W | 6.1 | 7 | 2 | 2 | 2 | 2 | 2 | 96 | 36 | 60 | 63% | 8-4 | 4.05 | 1.48 |
| 2004-06-24 | Brad Radke | R | 32 | W 4-3 | @ BOS | 16 | 300 | - | 6.2 | 8 | 3 | 3 | 1 | 1 | 5 | 120 | 42 | 78 | 65% | 4-3 | 3.23 | 1.22 |
| 2004-06-25 | Johan Santana | L | 25 | L 6-3 | vs MIL | 16 | 57 | W | 7.0 | 4 | 1 | 1 | 1 | 0 | 10 | 112 | 39 | 73 | 65% | 6-4 | 4.36 | 1.18 |
| 2004-06-26 | Matt Guerrier | R | 26 | W 2-7 | vs MIL | 2 | 2 | L | 4.0 | 6 | 4 | 4 | 1 | 1 | 0 | 64 | 23 | 41 | 64% | 0-1 | 6.00 | 1.67 |
| 2004-06-27 | Kyle Lohse | R | 26 | W 3-7 | vs MIL | 16 | 96 | L | 6.2 | 8 | 6 | 2 | 1 | 3 | 4 | 114 | 53 | 61 | 54% | 2-6 | 5.13 | 1.61 |
| 2004-06-29 | Carlos Silva | R | 25 | W 2-6 | vs CHA | 16 | 17 | L | 8.2 | 11 | 6 | 6 | 2 | 0 | 2 | 112 | 35 | 77 | 69% | 8-5 | 4.23 | 1.46 |
| 2004-06-30 | Brad Radke | R | 32 | W 6-9 | vs CHA | 17 | 301 | L | 6.0 | 11 | 8 | 8 | 3 | 0 | 2 | 97 | 25 | 72 | 74% | 4-4 | 3.72 | 1.26 |
| 2004-07-01 | Johan Santana | L | 25 | W 1-2 | vs CHA | 17 | 58 | L | 8.0 | 3 | 2 | 2 | 1 | 2 | 12 | 109 | 32 | 77 | 71% | 6-5 | 4.21 | 1.14 |
| 2004-07-02 | Kyle Lohse | R | 26 | W 6-5 | @ ARI | 17 | 97 | - | 5.0 | 11 | 5 | 3 | 0 | 0 | 0 | 77 | 29 | 48 | 62% | 2-6 | 5.14 | 1.64 |
| 2004-07-03 | Terry Mulholland | L | 41 | W 8-4 | @ ARI | 1 | 318 | W | 5.0 | 5 | 4 | 4 | 2 | 1 | 0 | 58 | 16 | 42 | 72% | 1-3 | 5.54 | 1.64 |
| 2004-07-04 | Carlos Silva | R | 25 | L 2-6 | @ ARI | 17 | 18 | L | 6.0 | 9 | 4 | 4 | 1 | 1 | 3 | 101 | 29 | 72 | 71% | 8-6 | 4.33 | 1.47 |
| 2004-07-05 | Brad Radke | R | 32 | L 9-0 | vs KCA | 18 | 302 | W | 9.0 | 4 | 0 | 0 | 0 | 0 | 4 | 102 | 28 | 74 | 73% | 5-4 | 3.43 | 1.19 |
| 2004-07-06 | Johan Santana | L | 25 | L 4-0 | vs KCA | 18 | 59 | W | 9.0 | 3 | 0 | 0 | 0 | 2 | 13 | 114 | 33 | 81 | 71% | 7-5 | 3.88 | 1.09 |
| 2004-07-07 | Kyle Lohse | R | 26 | L 12-0 | vs KCA | 18 | 98 | W | 9.0 | 6 | 0 | 0 | 0 | 0 | 7 | 117 | 36 | 81 | 69% | 3-6 | 4.71 | 1.56 |
| 2004-07-08 | Terry Mulholland | L | 41 | L 7-1 | vs DET | 2 | 319 | - | 5.2 | 7 | 1 | 1 | 1 | 1 | 7 | 81 | 22 | 59 | 73% | 1-3 | 5.00 | 1.60 |
| 2004-07-09 | Carlos Silva | R | 25 | W 3-5 | vs DET | 18 | 19 | L | 5.2 | 9 | 5 | 5 | 3 | 0 | 3 | 78 | 18 | 60 | 77% | 8-7 | 4.50 | 1.47 |
| 2004-07-10 | Brad Radke | R | 32 | W 2-4 | vs DET | 19 | 303 | L | 6.0 | 5 | 3 | 3 | 3 | 0 | 8 | 98 | 35 | 63 | 64% | 5-5 | 3.48 | 1.18 |
| 2004-07-11 | Johan Santana | L | 25 | W 0-2 | vs DET | 19 | 60 | L | 8.0 | 2 | 2 | 2 | 1 | 2 | 11 | 103 | 32 | 71 | 69% | 7-6 | 3.77 | 1.06 |
| 2004-07-15 | Kyle Lohse | R | 26 | L 1-3 | @ KCA | 19 | 99 | L | 5.0 | 8 | 3 | 3 | 0 | 2 | 2 | 106 | 44 | 62 | 58% | 3-7 | 4.74 | 1.58 |
| 2004-07-16 | Brad Radke | R | 32 | L 3-12 | @ KCA | 20 | 304 | L | 3.0 | 8 | 7 | 7 | 3 | 1 | 2 | 62 | 23 | 39 | 63% | 5-6 | 3.90 | 1.22 |
| 2004-07-17 | Johan Santana | L | 25 | W 4-1 | @ KCA | 20 | 61 | W | 8.0 | 1 | 1 | 0 | 0 | 4 | 9 | 120 | 50 | 70 | 58% | 8-6 | 3.55 | 1.03 |
| 2004-07-18 | Carlos Silva | R | 25 | L 3-4 | @ KCA | 19 | 20 | - | 7.0 | 6 | 3 | 3 | 0 | 2 | 0 | 84 | 28 | 56 | 67% | 8-7 | 4.46 | 1.45 |
| 2004-07-19 | Terry Mulholland | L | 41 | W 3-1 | @ DET | 3 | 320 | W | 6.2 | 4 | 1 | 1 | 0 | 1 | 2 | 80 | 28 | 52 | 65% | 2-3 | 4.59 | 1.51 |
| 2004-07-20 | Kyle Lohse | R | 26 | W 5-4 | @ DET | 20 | 100 | - | 5.0 | 7 | 4 | 4 | 1 | 3 | 4 | 96 | 36 | 60 | 63% | 3-7 | 4.85 | 1.60 |
| 2004-07-21 | Brad Radke | R | 32 | L 12-2 | vs TBA | 21 | 305 | W | 7.0 | 6 | 2 | 2 | 1 | 0 | 4 | 99 | 24 | 75 | 76% | 6-6 | 3.83 | 1.20 |
| 2004-07-22 | Johan Santana | L | 25 | L 7-5 | vs TBA | 21 | 62 | - | 7.0 | 3 | 1 | 1 | 1 | 3 | 10 | 101 | 33 | 68 | 67% | 8-6 | 3.43 | 1.02 |
| 2004-07-23 | Carlos Silva | R | 25 | W 7-3 | @ BAL | 20 | 21 | W | 6.0 | 9 | 3 | 3 | 0 | 0 | 2 | 94 | 37 | 57 | 61% | 9-7 | 4.46 | 1.46 |
| 2004-07-24 | Terry Mulholland | L | 41 | L 2-4 | @ BAL | 4 | 321 | - | 6.0 | 4 | 2 | 2 | 1 | 2 | 1 | 89 | 30 | 59 | 66% | 2-3 | 4.42 | 1.46 |
| 2004-07-25 | Kyle Lohse | R | 26 | W 8-4 | @ BAL | 21 | 101 | W | 5.0 | 7 | 4 | 3 | 0 | 0 | 0 | 69 | 22 | 47 | 68% | 4-7 | 4.87 | 1.59 |
| 2004-07-26 | Brad Radke | R | 32 | W 6-2 | @ CHA | 22 | 306 | W | 7.0 | 3 | 1 | 1 | 1 | 0 | 3 | 107 | 36 | 71 | 66% | 7-6 | 3.70 | 1.16 |
| 2004-07-27 | Johan Santana | L | 25 | W 7-3 | @ CHA | 22 | 63 | W | 6.0 | 2 | 1 | 1 | 1 | 2 | 6 | 108 | 41 | 67 | 62% | 9-6 | 3.35 | 1.01 |
| 2004-07-28 | Carlos Silva | R | 25 | W 5-4 | @ CHA | 21 | 22 | - | 6.2 | 7 | 4 | 4 | 1 | 2 | 1 | 113 | 47 | 66 | 58% | 9-7 | 4.53 | 1.46 |
| 2004-07-30 | Kyle Lohse | R | 26 | W 2-8 | vs BOS | 22 | 102 | L | 4.0 | 11 | 7 | 7 | 0 | 4 | 5 | 97 | 38 | 59 | 61% | 4-8 | 5.21 | 1.66 |
| 2004-07-31 | Brad Radke | R | 32 | L 5-4 | vs BOS | 23 | 307 | - | 6.2 | 7 | 4 | 4 | 1 | 1 | 3 | 104 | 38 | 66 | 63% | 7-6 | 3.77 | 1.16 |
| 2004-08-01 | Johan Santana | L | 25 | L 4-3 | vs BOS | 23 | 64 | W | 8.0 | 2 | 3 | 2 | 2 | 1 | 12 | 114 | 42 | 72 | 63% | 10-6 | 3.29 | 0.97 |
| 2004-08-03 | Carlos Silva | R | 25 | L 10-0 | vs ANA | 22 | 23 | W | 9.0 | 11 | 0 | 0 | 0 | 2 | 3 | 99 | 32 | 67 | 68% | 10-7 | 4.24 | 1.46 |
| 2004-08-04 | Kyle Lohse | R | 26 | L 6-3 | vs ANA | 23 | 103 | W | 7.0 | 9 | 3 | 3 | 1 | 1 | 4 | 98 | 31 | 67 | 68% | 5-8 | 5.14 | 1.65 |
| 2004-08-05 | Terry Mulholland | L | 41 | W 3-8 | vs ANA | 5 | 322 | L | 3.2 | 9 | 7 | 5 | 0 | 1 | 1 | 66 | 23 | 43 | 65% | 3-4 | 4.79 | 1.53 |
| 2004-08-06 | Brad Radke | R | 32 | W 1-3 | vs OAK | 24 | 308 | - | 9.0 | 5 | 1 | 1 | 0 | 2 | 7 | 112 | 36 | 76 | 68% | 7-6 | 3.61 | 1.14 |
| 2004-08-07 | Johan Santana | L | 25 | L 4-3 | vs OAK | 24 | 65 | W | 6.1 | 7 | 3 | 3 | 0 | 1 | 10 | 106 | 35 | 71 | 67% | 11-6 | 3.34 | 0.99 |
| 2004-08-08 | Carlos Silva | R | 25 | W 5-6 | vs OAK | 23 | 24 | - | 7.0 | 8 | 3 | 3 | 0 | 1 | 3 | 103 | 34 | 69 | 67% | 10-7 | 4.22 | 1.45 |
| 2004-08-09 | Kyle Lohse | R | 26 | W 2-8 | vs OAK | 24 | 104 | L | 6.1 | 8 | 4 | 4 | 0 | 4 | 5 | 118 | 45 | 73 | 62% | 5-9 | 5.18 | 1.66 |
| 2004-08-10 | Terry Mulholland | L | 41 | L 3-4 | @ SEA | 6 | 323 | L | 7.0 | 10 | 4 | 4 | 2 | 1 | 3 | 98 | 36 | 62 | 63% | 3-6 | 5.14 | 1.59 |
| 2004-08-11 | Brad Radke | R | 32 | L 3-4 | @ SEA | 25 | 309 | - | 6.0 | 5 | 3 | 3 | 0 | 2 | 4 | 102 | 37 | 65 | 64% | 7-6 | 3.64 | 1.14 |
| 2004-08-12 | Johan Santana | L | 25 | W 6-3 | @ SEA | 25 | 66 | W | 7.0 | 7 | 1 | 1 | 1 | 2 | 7 | 110 | 38 | 72 | 65% | 12-6 | 3.25 | 1.00 |
| 2004-08-13 | Carlos Silva | R | 25 | L 2-8 | @ CLE | 24 | 25 | L | 2.0 | 6 | 6 | 6 | 1 | 1 | 0 | 49 | 21 | 28 | 57% | 10-8 | 4.53 | 1.48 |
| 2004-08-14 | Kyle Lohse | R | 26 | L 1-7 | @ CLE | 25 | 105 | L | 5.0 | 7 | 7 | 7 | 3 | 2 | 3 | 104 | 45 | 59 | 57% | 5-10 | 5.44 | 1.67 |
| 2004-08-15 | Terry Mulholland | L | 41 | W 4-2 | @ CLE | 7 | 324 | - | 8.0 | 6 | 2 | 1 | 0 | 1 | 2 | 95 | 28 | 67 | 71% | 3-6 | 4.73 | 1.51 |
| 2004-08-17 | Brad Radke | R | 32 | L 8-2 | vs NYA | 26 | 310 | W | 7.0 | 6 | 1 | 1 | 1 | 1 | 5 | 97 | 30 | 67 | 69% | 8-6 | 3.55 | 1.14 |
| 2004-08-18 | Johan Santana | L | 25 | L 7-2 | vs NYA | 26 | 67 | W | 7.0 | 5 | 2 | 2 | 0 | 1 | 6 | 105 | 36 | 69 | 66% | 13-6 | 3.23 | 0.99 |
| 2004-08-19 | Carlos Silva | R | 25 | W 10-13 | vs NYA | 25 | 26 | - | 5.0 | 9 | 7 | 7 | 1 | 1 | 4 | 77 | 26 | 51 | 66% | 10-8 | 4.79 | 1.49 |
| 2004-08-20 | Kyle Lohse | R | 26 | L 5-1 | vs CLE | 26 | 106 | W | 7.0 | 3 | 1 | 1 | 1 | 1 | 4 | 108 | 43 | 65 | 60% | 6-10 | 5.25 | 1.62 |
| 2004-08-21 | Terry Mulholland | L | 41 | L 8-1 | vs CLE | 8 | 325 | W | 6.0 | 7 | 1 | 1 | 1 | 2 | 4 | 101 | 35 | 66 | 65% | 4-6 | 4.50 | 1.51 |
| 2004-08-22 | Brad Radke | R | 32 | L 7-3 | vs CLE | 27 | 311 | W | 7.0 | 7 | 2 | 0 | 0 | 1 | 4 | 111 | 32 | 79 | 71% | 9-6 | 3.41 | 1.14 |
| 2004-08-23 | Johan Santana | L | 25 | W 7-4 | @ TEX | 27 | 68 | W | 8.0 | 4 | 1 | 1 | 1 | 1 | 11 | 107 | 38 | 69 | 64% | 14-6 | 3.13 | 0.98 |
| 2004-08-24 | Carlos Silva | R | 25 | L 4-5 | @ TEX | 26 | 27 | - | 6.1 | 6 | 2 | 2 | 0 | 1 | 1 | 81 | 25 | 56 | 69% | 10-8 | 4.70 | 1.47 |
| 2004-08-25 | Kyle Lohse | R | 26 | W 8-5 | @ TEX | 27 | 107 | W | 5.0 | 8 | 5 | 5 | 2 | 0 | 3 | 84 | 29 | 55 | 65% | 7-10 | 5.37 | 1.62 |
| 2004-08-26 | Terry Mulholland | L | 41 | L 3-8 | @ TEX | 9 | 326 | L | 3.2 | 9 | 7 | 7 | 1 | 1 | 1 | 74 | 26 | 48 | 65% | 4-7 | 5.01 | 1.56 |
| 2004-08-27 | Brad Radke | R | 32 | L 6-9 | @ ANA | 28 | 312 | L | 5.2 | 15 | 9 | 9 | 2 | 0 | 4 | 85 | 20 | 65 | 76% | 9-7 | 3.74 | 1.18 |
| 2004-08-28 | Johan Santana | L | 25 | W 7-1 | @ ANA | 28 | 69 | W | 7.0 | 4 | 1 | 1 | 0 | 1 | 6 | 103 | 29 | 74 | 72% | 15-6 | 3.06 | 0.97 |
| 2004-08-29 | Carlos Silva | R | 25 | L 2-4 | @ ANA | 27 | 28 | - | 5.0 | 4 | 1 | 1 | 0 | 1 | 2 | 68 | 25 | 43 | 63% | 10-8 | 4.61 | 1.46 |
| 2004-08-31 | Kyle Lohse | R | 26 | L 8-5 | vs TEX | 28 | 108 | - | 4.2 | 8 | 5 | 5 | 0 | 2 | 4 | 85 | 37 | 48 | 56% | 7-10 | 5.48 | 1.63 |
| 2004-09-01 | Terry Mulholland | L | 41 | L 4-2 | vs TEX | 10 | 327 | - | 6.0 | 8 | 2 | 2 | 0 | 1 | 4 | 102 | 36 | 66 | 65% | 4-7 | 4.88 | 1.55 |
| 2004-09-02 | Brad Radke | R | 32 | L 2-0 | vs TEX | 29 | 313 | W | 8.0 | 5 | 0 | 0 | 0 | 1 | 9 | 111 | 30 | 81 | 73% | 10-7 | 3.58 | 1.16 |
| 2004-09-03 | Johan Santana | L | 25 | L 2-0 | vs KCA | 29 | 70 | W | 7.0 | 1 | 0 | 0 | 0 | 1 | 11 | 105 | 35 | 70 | 67% | 16-6 | 2.95 | 0.94 |
| 2004-09-04 | Carlos Silva | R | 25 | L 4-3 | vs KCA | 28 | 29 | - | 6.0 | 7 | 2 | 2 | 0 | 1 | 2 | 84 | 32 | 52 | 62% | 10-8 | 4.55 | 1.45 |
| 2004-09-05 | Kyle Lohse | R | 26 | W 3-12 | vs KCA | 29 | 109 | L | 3.2 | 7 | 6 | 3 | 1 | 2 | 4 | 92 | 37 | 55 | 60% | 7-11 | 5.51 | 1.64 |
| 2004-09-06 | Terry Mulholland | L | 41 | L 1-4 | @ BAL | 11 | 328 | L | 5.0 | 9 | 4 | 4 | 1 | 4 | 4 | 94 | 35 | 59 | 63% | 4-8 | 5.00 | 1.61 |
| 2004-09-07 | Brad Radke | R | 32 | W 3-1 | @ BAL | 30 | 314 | - | 7.0 | 5 | 1 | 1 | 0 | 0 | 2 | 100 | 33 | 67 | 67% | 10-7 | 3.50 | 1.15 |
| 2004-09-08 | Johan Santana | L | 25 | W 9-0 | @ BAL | 30 | 71 | W | 7.0 | 5 | 0 | 0 | 0 | 0 | 9 | 103 | 29 | 74 | 72% | 17-6 | 2.85 | 0.94 |
| 2004-09-10 | Carlos Silva | R | 25 | W 4-1 | @ DET | 29 | 30 | W | 6.0 | 9 | 1 | 1 | 0 | 0 | 6 | 92 | 34 | 58 | 63% | 11-8 | 4.45 | 1.46 |
| 2004-09-11 | Kyle Lohse | R | 26 | W 3-2 | @ DET | 30 | 110 | - | 5.1 | 6 | 2 | 2 | 0 | 4 | 5 | 105 | 46 | 59 | 56% | 7-11 | 5.45 | 1.65 |
| 2004-09-12 | Terry Mulholland | L | 42 | W 8-5 | @ DET | 12 | 329 | W | 6.2 | 10 | 4 | 4 | 1 | 0 | 4 | 89 | 26 | 63 | 71% | 5-8 | 5.06 | 1.61 |
| 2004-09-13 | Brad Radke | R | 32 | W 5-3 | @ DET | 31 | 315 | W | 7.0 | 7 | 1 | 1 | 0 | 0 | 2 | 92 | 25 | 67 | 73% | 11-7 | 3.42 | 1.14 |
| 2004-09-14 | Johan Santana | L | 26 | L 10-2 | vs CHA | 31 | 72 | W | 7.0 | 2 | 0 | 0 | 0 | 1 | 7 | 88 | 32 | 56 | 64% | 18-6 | 2.76 | 0.92 |
| 2004-09-15 | Carlos Silva | R | 25 | L 6-1 | vs CHA | 30 | 31 | W | 5.1 | 1 | 0 | 0 | 0 | 2 | 2 | 60 | 23 | 37 | 62% | 12-8 | 4.33 | 1.43 |
| 2004-09-16 | Kyle Lohse | R | 26 | L 10-1 | vs CHA | 31 | 111 | W | 7.0 | 4 | 1 | 1 | 0 | 1 | 2 | 95 | 32 | 63 | 66% | 8-11 | 5.29 | 1.62 |
| 2004-09-17 | Terry Mulholland | L | 42 | W 2-11 | vs BAL | 13 | 330 | L | 5.2 | 6 | 4 | 4 | 1 | 3 | 3 | 101 | 42 | 59 | 58% | 5-9 | 5.11 | 1.60 |
| 2004-09-18 | Brad Radke | R | 32 | W 3-12 | vs BAL | 32 | 316 | L | 3.0 | 5 | 3 | 3 | 1 | 2 | 1 | 79 | 27 | 52 | 66% | 11-8 | 3.50 | 1.16 |
| 2004-09-19 | Johan Santana | L | 26 | L 5-1 | vs BAL | 32 | 73 | W | 8.0 | 7 | 0 | 0 | 0 | 0 | 14 | 103 | 25 | 78 | 76% | 19-6 | 2.65 | 0.92 |
| 2004-09-20 | Carlos Silva | R | 25 | W 8-2 | @ CHA | 31 | 32 | W | 7.0 | 7 | 2 | 2 | 1 | 1 | 0 | 89 | 32 | 57 | 64% | 13-8 | 4.26 | 1.42 |
| 2004-09-21 | Kyle Lohse | R | 26 | L 6-8 | @ CHA | 32 | 112 | - | 6.0 | 7 | 4 | 4 | 1 | 6 | 3 | 103 | 47 | 56 | 54% | 8-11 | 5.31 | 1.63 |
| 2004-09-22 | Terry Mulholland | L | 42 | L 6-7 | @ CHA | 14 | 331 | - | 5.1 | 9 | 6 | 6 | 0 | 1 | 4 | 88 | 33 | 55 | 63% | 5-9 | 5.35 | 1.62 |
| 2004-09-23 | J.D. Durbin | R | 23 | L 7-9 | @ CLE | 1 | 1 | L | 3.0 | 7 | 5 | 5 | 0 | 4 | 2 | 66 | 34 | 32 | 48% | 0-1 | 7.71 | 2.57 |
| 2004-09-24 | Johan Santana | L | 26 | W 8-2 | @ CLE | 33 | 74 | W | 6.0 | 2 | 1 | 1 | 0 | 4 | 6 | 92 | 36 | 56 | 61% | 20-6 | 2.62 | 0.92 |
| 2004-09-25 | Brad Radke | R | 32 | L 3-5 | @ CLE | 33 | 317 | - | 7.0 | 3 | 2 | 2 | 1 | 3 | 6 | 111 | 53 | 58 | 52% | 11-8 | 3.47 | 1.15 |
| 2004-09-26 | Carlos Silva | R | 25 | W 6-2 | @ CLE | 32 | 33 | W | 7.0 | 8 | 1 | 1 | 0 | 2 | 1 | 96 | 37 | 59 | 61% | 14-8 | 4.16 | 1.42 |
| 2004-09-29 | Johan Santana | L | 26 | L 3-5 | @ NYA | 34 | 75 | - | 5.0 | 3 | 1 | 1 | 0 | 1 | 5 | 71 | 23 | 48 | 68% | 20-6 | 2.61 | 0.92 |
| 2004-09-29 | Kyle Lohse | R | 26 | L 4-5 | @ NYA | 33 | 113 | L | 6.0 | 7 | 5 | 4 | 2 | 3 | 4 | 123 | 56 | 67 | 54% | 8-12 | 5.33 | 1.63 |
| 2004-09-30 | Brad Radke | R | 32 | L 4-6 | @ NYA | 34 | 318 | - | 5.0 | 6 | 2 | 2 | 0 | 2 | 2 | 82 | 29 | 53 | 65% | 11-8 | 3.48 | 1.16 |
| 2004-10-01 | Terry Mulholland | L | 42 | L 4-3 | vs CLE | 15 | 332 | - | 7.0 | 7 | 3 | 2 | 1 | 1 | 0 | 87 | 33 | 54 | 62% | 5-9 | 5.20 | 1.59 |
| 2004-10-02 | Carlos Silva | R | 25 | L 6-5 | vs CLE | 33 | 34 | - | 6.0 | 9 | 4 | 4 | 2 | 1 | 2 | 88 | 32 | 56 | 64% | 14-8 | 4.21 | 1.43 |
| 2004-10-03 | Kyle Lohse | R | 26 | W 2-5 | vs CLE | 34 | 114 | L | 4.0 | 5 | 3 | 3 | 1 | 0 | 5 | 57 | 11 | 46 | 81% | 9-13 | 5.34 | 1.63 |