| 2004-04-06 | @ SEA | 1 | W 10-5 | 1-0 | 1 | 46,142 | Bartolo Colon | Jamie Moyer | Bartolo Colon | Jamie Moyer | | 10 | 5 | 5 |
| 2004-04-07 | @ SEA | 2 | W 10-7 | 2-0 | 1 | 37,947 | Jarrod Washburn | Joel Pineiro | Jarrod Washburn | Joel Pineiro | Troy Percival | 20 | 12 | 8 |
| 2004-04-08 | @ SEA | 3 | W 5-1 | 3-0 | 1 | 34,376 | Kelvim Escobar | Freddy Garcia | Scot Shields | Shigetoshi Hasegawa | | 25 | 13 | 12 |
| 2004-04-09 | @ TEX | 4 | L 4-12 | 3-1 | 1 | 50,370 | Ramon Ortiz | R.A. Dickey | R.A. Dickey | Ramon Ortiz | | 29 | 25 | 4 |
| 2004-04-10 | @ TEX | 5 | L 6-12 | 3-2 | 2 | 30,331 | John Lackey | Kenny Rogers | Kenny Rogers | John Lackey | | 35 | 37 | -2 |
| 2004-04-11 | @ TEX | 6 | W 7-2 | 4-2 | 1 | 18,209 | Bartolo Colon | Chan Ho Park | Bartolo Colon | Chan Ho Park | | 42 | 39 | 3 |
| 2004-04-12 | @ TEX | 7 | L 6-7 | 4-3 | 2 | 18,156 | Jarrod Washburn | Colby Lewis | Carlos Almanzar | Jarrod Washburn | Francisco Cordero | 48 | 46 | 2 |
| 2004-04-13 | vs SEA | 8 | W 7-5 | 5-3 | 2 | 43,443 | Kelvim Escobar | Joel Pineiro | Scot Shields | Rafael Soriano | Troy Percival | 55 | 51 | 4 |
| 2004-04-14 | vs SEA | 9 | W 6-5 | 6-3 | 2 | 42,888 | Ramon Ortiz | Freddy Garcia | Troy Percival | Shigetoshi Hasegawa | | 61 | 56 | 5 |
| 2004-04-15 | vs SEA | 10 | L 2-6 | 6-4 | 2 | 40,032 | John Lackey | Ryan Franklin | Ryan Franklin | John Lackey | | 63 | 62 | 1 |
| 2004-04-16 | vs OAK | 11 | L 0-3 | 6-5 | 2 | 43,657 | Bartolo Colon | Tim Hudson | Tim Hudson | Bartolo Colon | Arthur Rhodes | 63 | 65 | -2 |
| 2004-04-17 | vs OAK | 12 | W 6-3 | 7-5 | 2 | 43,487 | Jarrod Washburn | Mark Mulder | Jarrod Washburn | Mark Mulder | | 69 | 68 | 1 |
| 2004-04-18 | vs OAK | 13 | L 1-7 | 7-6 | 2 | 43,411 | Kelvim Escobar | Barry Zito | Barry Zito | Kelvim Escobar | Chris Hammond | 70 | 75 | -5 |
| 2004-04-20 | vs TEX | 14 | L 3-6 | 7-7 | 2 | 33,892 | Ramon Ortiz | Kenny Rogers | Kenny Rogers | Ramon Ortiz | Francisco Cordero | 73 | 81 | -8 |
| 2004-04-21 | vs TEX | 15 | L 1-4 | 7-8 | 3 | 36,689 | John Lackey | R.A. Dickey | R.A. Dickey | John Lackey | Francisco Cordero | 74 | 85 | -11 |
| 2004-04-22 | vs TEX | 16 | W 7-5 | 8-8 | 2 | 30,725 | Bartolo Colon | Chan Ho Park | Bartolo Colon | Chan Ho Park | Troy Percival | 81 | 90 | -9 |
| 2004-04-23 | @ OAK | 17 | W 12-2 | 9-8 | 2 | 23,507 | Jarrod Washburn | Barry Zito | Jarrod Washburn | Barry Zito | Kevin Gregg | 93 | 92 | 1 |
| 2004-04-24 | @ OAK | 18 | W 6-3 | 10-8 | 1 | 25,739 | Kelvim Escobar | Mark Redman | Kelvim Escobar | Mark Redman | Troy Percival | 99 | 95 | 4 |
| 2004-04-25 | @ OAK | 19 | W 4-3 | 11-8 | 1 | 33,567 | Ramon Ortiz | Rich Harden | Ramon Ortiz | Rich Harden | Troy Percival | 103 | 98 | 5 |
| 2004-04-27 | @ DET | 20 | W 10-4 | 12-8 | 1 | 18,208 | John Lackey | Nate Cornejo | John Lackey | Nate Cornejo | Scot Shields | 113 | 102 | 11 |
| 2004-04-28 | @ DET | 21 | L 2-10 | 12-9 | 1 | 17,175 | Bartolo Colon | Mike Maroth | Mike Maroth | Bartolo Colon | | 115 | 112 | 3 |
| 2004-04-29 | @ DET | 22 | W 12-3 | 13-9 | 1 | 20,678 | Jarrod Washburn | Nate Robertson | Jarrod Washburn | Nate Robertson | | 127 | 115 | 12 |
| 2004-04-30 | @ MIN | 23 | L 3-6 | 13-10 | 2 | 21,279 | Ramon Ortiz | Carlos Silva | Carlos Silva | Ramon Ortiz | Joe Nathan | 130 | 121 | 9 |
| 2004-05-01 | @ MIN | 24 | W 1-0 | 14-10 | 2 | 26,180 | Aaron Sele | Brad Radke | Francisco Rodriguez | Juan Rincon | Troy Percival | 131 | 121 | 10 |
| 2004-05-02 | @ MIN | 25 | W 3-1 | 15-10 | 2 | 20,744 | John Lackey | Johan Santana | John Lackey | J.C. Romero | Troy Percival | 134 | 122 | 12 |
| 2004-05-03 | vs DET | 26 | W 11-9 | 16-10 | 2 | 33,683 | Bartolo Colon | Mike Maroth | Kevin Gregg | Al Levine | Troy Percival | 145 | 131 | 14 |
| 2004-05-04 | vs DET | 27 | W 11-4 | 17-10 | 1 | 34,920 | Jarrod Washburn | Nate Robertson | Jarrod Washburn | Nate Robertson | | 156 | 135 | 21 |
| 2004-05-05 | vs DET | 28 | W 6-3 | 18-10 | 1 | 39,827 | Kelvim Escobar | Jason Johnson | Kelvim Escobar | Jason Johnson | Troy Percival | 162 | 138 | 24 |
| 2004-05-06 | vs TBA | 29 | W 7-3 | 19-10 | 1 | 34,538 | Aaron Sele | Geremi Gonzalez | Aaron Sele | Geremi Gonzalez | Scot Shields | 169 | 141 | 28 |
| 2004-05-07 | vs TBA | 30 | W 1-0 | 20-10 | 1 | 43,674 | John Lackey | Mark Hendrickson | John Lackey | Mark Hendrickson | | 170 | 141 | 29 |
| 2004-05-08 | vs TBA | 31 | W 7-2 | 21-10 | 1 | 43,465 | Bartolo Colon | Paul Abbott | Bartolo Colon | Paul Abbott | | 177 | 143 | 34 |
| 2004-05-09 | vs TBA | 32 | W 8-4 | 22-10 | 1 | 41,410 | Jarrod Washburn | Victor Zambrano | Jarrod Washburn | Victor Zambrano | Francisco Rodriguez | 185 | 147 | 38 |
| 2004-05-11 | @ NYA | 33 | L 7-8 | 22-11 | 1 | 36,706 | Kelvim Escobar | Kevin Brown | Tom Gordon | Ben Weber | | 192 | 155 | 37 |
| 2004-05-12 | @ NYA | 34 | W 11-2 | 23-11 | 1 | 49,954 | Aaron Sele | Javier Vazquez | Aaron Sele | Javier Vazquez | | 203 | 157 | 46 |
| 2004-05-13 | @ NYA | 35 | L 4-7 | 23-12 | 1 | 41,089 | John Lackey | Jon Lieber | Jon Lieber | John Lackey | Mariano Rivera | 207 | 164 | 43 |
| 2004-05-14 | @ BAL | 36 | W 10-9 | 24-12 | 1 | 38,232 | Bartolo Colon | Kurt Ainsworth | Troy Percival | Jorge Julio | Scot Shields | 217 | 173 | 44 |
| 2004-05-15 | @ BAL | 37 | W 7-4 | 25-12 | 1 | 40,275 | Jarrod Washburn | Eric DuBose | Jarrod Washburn | Eric DuBose | Troy Percival | 224 | 177 | 47 |
| 2004-05-16 | @ BAL | 38 | L 0-4 | 25-13 | 1 | 25,448 | Kelvim Escobar | Sidney Ponson | Sidney Ponson | Kelvim Escobar | | 224 | 181 | 43 |
| 2004-05-18 | vs NYA | 39 | W 1-0 | 26-13 | 1 | 43,660 | Aaron Sele | Javier Vazquez | Scot Shields | Paul Quantrill | | 225 | 181 | 44 |
| 2004-05-19 | vs NYA | 40 | L 2-4 | 26-14 | 1 | 43,742 | John Lackey | Jon Lieber | Jon Lieber | John Lackey | Mariano Rivera | 227 | 185 | 42 |
| 2004-05-20 | vs NYA | 41 | L 2-6 | 26-15 | 1 | 43,810 | Bartolo Colon | Mike Mussina | Mike Mussina | Bartolo Colon | | 229 | 191 | 38 |
| 2004-05-21 | vs BAL | 42 | W 5-3 | 27-15 | 1 | 43,557 | Jarrod Washburn | Eric DuBose | Scot Shields | Mike DeJean | Troy Percival | 234 | 194 | 40 |
| 2004-05-22 | vs BAL | 43 | W 3-2 | 28-15 | 1 | 43,586 | Kelvim Escobar | Sidney Ponson | Kelvim Escobar | Sidney Ponson | Troy Percival | 237 | 196 | 41 |
| 2004-05-23 | vs BAL | 44 | W 8-3 | 29-15 | 1 | 43,758 | Aaron Sele | Daniel Cabrera | Aaron Sele | Daniel Cabrera | | 245 | 199 | 46 |
| 2004-05-24 | @ TOR | 45 | L 5-6 | 29-16 | 1 | 15,301 | John Lackey | Justin Miller | Jason Frasor | Ben Weber | | 250 | 205 | 45 |
| 2004-05-26 | @ TOR | 46 | L 5-6 | 29-17 | 1 | 14,515 | Bartolo Colon | Pat Hentgen | Terry Adams | Troy Percival | | 255 | 211 | 44 |
| 2004-05-27 | @ TOR | 47 | L 2-3 | 29-18 | 1 | 14,773 | Jarrod Washburn | Roy Halladay | Roy Halladay | Jarrod Washburn | Jason Frasor | 257 | 214 | 43 |
| 2004-05-28 | @ CHA | 48 | L 3-4 | 29-19 | 1 | 21,163 | Kelvim Escobar | Jon Garland | Shingo Takatsu | Ramon Ortiz | | 260 | 218 | 42 |
| 2004-05-29 | @ CHA | 49 | W 5-1 | 30-19 | 1 | 25,050 | Aaron Sele | Jon Rauch | Aaron Sele | Jon Rauch | | 265 | 219 | 46 |
| 2004-05-30 | @ CHA | 50 | L 2-11 | 30-20 | 1 | 19,859 | John Lackey | Scott Schoeneweis | Scott Schoeneweis | John Lackey | | 267 | 230 | 37 |
| 2004-06-01 | vs BOS | 51 | W 7-6 | 31-20 | 1 | 43,285 | Bartolo Colon | Bronson Arroyo | Kevin Gregg | Bronson Arroyo | Troy Percival | 274 | 236 | 38 |
| 2004-06-02 | vs BOS | 52 | W 10-7 | 32-20 | 1 | 43,205 | Jarrod Washburn | Pedro Martinez | Ramon Ortiz | Mike Timlin | Francisco Rodriguez | 284 | 243 | 41 |
| 2004-06-03 | vs CLE | 53 | W 5-2 | 33-20 | 1 | 39,353 | Kelvim Escobar | Cliff Lee | Kelvim Escobar | Cliff Lee | | 289 | 245 | 44 |
| 2004-06-04 | vs CLE | 54 | L 6-9 | 33-21 | 1 | 43,590 | Aaron Sele | Jason Davis | David Riske | Francisco Rodriguez | Jose Jimenez | 295 | 254 | 41 |
| 2004-06-05 | vs CLE | 55 | L 2-3 | 33-22 | 1 | 43,514 | John Lackey | Joey Dawley | Rick White | John Lackey | Jose Jimenez | 297 | 257 | 40 |
| 2004-06-06 | vs CLE | 56 | L 0-7 | 33-23 | 1 | 43,337 | Bartolo Colon | CC Sabathia | CC Sabathia | Bartolo Colon | | 297 | 264 | 33 |
| 2004-06-08 | vs MIL | 57 | L 0-1 | 33-24 | 1 | 37,589 | Kelvim Escobar | Ben Sheets | Matt Kinney | Ramon Ortiz | Danny Kolb | 297 | 265 | 32 |
| 2004-06-09 | vs MIL | 58 | L 2-12 | 33-25 | 2 | 41,423 | Jarrod Washburn | Victor Santos | Victor Santos | Jarrod Washburn | Dave Burba | 299 | 277 | 22 |
| 2004-06-10 | vs MIL | 59 | W 5-4 | 34-25 | 3 | 39,425 | Aaron Sele | Wes Obermueller | Kevin Gregg | Jeff Bennett | Francisco Rodriguez | 304 | 281 | 23 |
| 2004-06-11 | vs CHN | 60 | W 3-2 | 35-25 | 2 | 43,764 | John Lackey | Greg Maddux | John Lackey | Greg Maddux | Francisco Rodriguez | 307 | 283 | 24 |
| 2004-06-12 | vs CHN | 61 | L 5-10 | 35-26 | 3 | 43,722 | Bartolo Colon | Glendon Rusch | Glendon Rusch | Bartolo Colon | LaTroy Hawkins | 312 | 293 | 19 |
| 2004-06-13 | vs CHN | 62 | L 5-6 | 35-27 | 3 | 43,812 | Kelvim Escobar | Matt Clement | Jon Leicester | Matt Hensley | | 317 | 299 | 18 |
| 2004-06-15 | @ PIT | 63 | W 4-2 | 36-27 | 2 | 19,035 | Jarrod Washburn | Oliver Perez | Scot Shields | Salomon Torres | Francisco Rodriguez | 321 | 301 | 20 |
| 2004-06-16 | @ PIT | 64 | L 3-5 | 36-28 | 2 | 22,404 | John Lackey | Josh Fogg | Josh Fogg | John Lackey | Jose Mesa | 324 | 306 | 18 |
| 2004-06-17 | @ PIT | 65 | L 2-5 | 36-29 | 2 | 15,395 | Bartolo Colon | Kris Benson | Kris Benson | Bartolo Colon | Jose Mesa | 326 | 311 | 15 |
| 2004-06-18 | @ HOU | 66 | L 0-5 | 36-30 | 3 | 38,328 | Kelvim Escobar | Peter Munro | Peter Munro | Kelvim Escobar | | 326 | 316 | 10 |
| 2004-06-19 | @ HOU | 67 | W 6-4 | 37-30 | 3 | 42,449 | Ramon Ortiz | Roger Clemens | Ramon Ortiz | Roger Clemens | Francisco Rodriguez | 332 | 320 | 12 |
| 2004-06-20 | @ HOU | 68 | L 1-3 | 37-31 | 3 | 41,590 | Jarrod Washburn | Wade Miller | Wade Miller | Matt Hensley | Octavio Dotel | 333 | 323 | 10 |
| 2004-06-21 | vs OAK | 69 | W 10-3 | 38-31 | 3 | 43,058 | John Lackey | Rich Harden | John Lackey | Rich Harden | | 343 | 326 | 17 |
| 2004-06-22 | vs OAK | 70 | W 6-1 | 39-31 | 2 | 43,021 | Bartolo Colon | Tim Hudson | Bartolo Colon | Tim Hudson | | 349 | 327 | 22 |
| 2004-06-23 | vs OAK | 71 | L 1-7 | 39-32 | 3 | 42,774 | Kelvim Escobar | Mark Redman | Mark Redman | Kelvim Escobar | | 350 | 334 | 16 |
| 2004-06-24 | vs OAK | 72 | L 1-2 | 39-33 | 3 | 43,461 | Ramon Ortiz | Mark Mulder | Mark Mulder | Scot Shields | | 351 | 336 | 15 |
| 2004-06-25 | @ LAN | 73 | W 13-0 | 40-33 | 3 | 54,617 | Jarrod Washburn | Jose Lima | Jarrod Washburn | Jose Lima | | 364 | 336 | 28 |
| 2004-06-26 | @ LAN | 74 | W 7-5 | 41-33 | 3 | 52,715 | Aaron Sele | Odalis Perez | Brendan Donnelly | Guillermo Mota | Francisco Rodriguez | 371 | 341 | 30 |
| 2004-06-27 | @ LAN | 75 | L 5-10 | 41-34 | 3 | 54,333 | Bartolo Colon | Kazuhisa Ishii | Kazuhisa Ishii | Bartolo Colon | | 376 | 351 | 25 |
| 2004-06-29 | @ OAK | 76 | L 4-5 | 41-35 | 3 | 20,328 | Kelvim Escobar | Mark Mulder | Mark Mulder | Brendan Donnelly | Octavio Dotel | 380 | 356 | 24 |
| 2004-06-30 | @ OAK | 77 | L 2-4 | 41-36 | 3 | 35,016 | John Lackey | Barry Zito | Chad Bradford | Scot Shields | Octavio Dotel | 382 | 360 | 22 |
| 2004-07-01 | @ OAK | 78 | L 3-7 | 41-37 | 3 | 22,114 | Jarrod Washburn | Kirk Saarloos | Kirk Saarloos | Jarrod Washburn | | 385 | 367 | 18 |
| 2004-07-02 | vs LAN | 79 | W 7-3 | 42-37 | 3 | 43,816 | Aaron Sele | Kazuhisa Ishii | Aaron Sele | Kazuhisa Ishii | | 392 | 370 | 22 |
| 2004-07-03 | vs LAN | 80 | L 5-8 | 42-38 | 3 | 43,686 | Bartolo Colon | Edwin Jackson | Guillermo Mota | Bartolo Colon | Eric Gagne | 397 | 378 | 19 |
| 2004-07-04 | vs LAN | 81 | L 2-6 | 42-39 | 3 | 43,823 | Kelvim Escobar | Jeff Weaver | Jeff Weaver | Kelvim Escobar | | 399 | 384 | 15 |
| 2004-07-06 | @ CHA | 82 | W 6-2 | 43-39 | 3 | 26,209 | John Lackey | Freddy Garcia | John Lackey | Freddy Garcia | | 405 | 386 | 19 |
| 2004-07-07 | @ CHA | 83 | W 12-0 | 44-39 | 3 | 21,378 | Jarrod Washburn | Scott Schoeneweis | Jarrod Washburn | Scott Schoeneweis | | 417 | 386 | 31 |
| 2004-07-08 | @ CHA | 84 | L 8-9 | 44-40 | 3 | 27,845 | Aaron Sele | Esteban Loaiza | Damaso Marte | Brendan Donnelly | | 425 | 395 | 30 |
| 2004-07-09 | @ TOR | 85 | W 5-4 | 45-40 | 3 | 15,071 | Bartolo Colon | Roy Halladay | Bartolo Colon | Roy Halladay | Troy Percival | 430 | 399 | 31 |
| 2004-07-10 | @ TOR | 86 | W 11-2 | 46-40 | 3 | 20,635 | Kelvim Escobar | Ted Lilly | Kelvim Escobar | Ted Lilly | | 441 | 401 | 40 |
| 2004-07-11 | @ TOR | 87 | W 5-2 | 47-40 | 3 | 17,573 | John Lackey | Miguel Batista | John Lackey | Miguel Batista | Troy Percival | 446 | 403 | 43 |
| 2004-07-15 | vs BOS | 88 | W 8-1 | 48-40 | 3 | 43,623 | Jarrod Washburn | Derek Lowe | Jarrod Washburn | Derek Lowe | | 454 | 404 | 50 |
| 2004-07-16 | vs BOS | 89 | L 2-4 | 48-41 | 3 | 43,771 | Kelvim Escobar | Pedro Martinez | Pedro Martinez | Kelvim Escobar | Keith Foulke | 456 | 408 | 48 |
| 2004-07-17 | vs BOS | 90 | W 8-3 | 49-41 | 3 | 43,746 | Bartolo Colon | Tim Wakefield | Bartolo Colon | Tim Wakefield | | 464 | 411 | 53 |
| 2004-07-18 | vs BOS | 91 | L 2-6 | 49-42 | 3 | 43,613 | John Lackey | Curt Schilling | Curt Schilling | John Lackey | | 466 | 417 | 49 |
| 2004-07-19 | vs CLE | 92 | L 5-8 | 49-43 | 3 | 42,986 | Aaron Sele | Kazuhito Tadano | David Riske | Troy Percival | Matt Miller | 471 | 425 | 46 |
| 2004-07-20 | vs CLE | 93 | L 5-14 | 49-44 | 3 | 40,000 | Jarrod Washburn | Jake Westbrook | Jake Westbrook | Jarrod Washburn | | 476 | 439 | 37 |
| 2004-07-21 | @ TEX | 94 | L 2-3 | 49-45 | 3 | 37,210 | Kelvim Escobar | Ryan Drese | Ryan Drese | Kelvim Escobar | Francisco Cordero | 478 | 442 | 36 |
| 2004-07-22 | @ TEX | 95 | W 11-1 | 50-45 | 3 | 23,308 | Bartolo Colon | Ricardo Rodriguez | Bartolo Colon | Ricardo Rodriguez | | 489 | 443 | 46 |
| 2004-07-23 | @ SEA | 96 | W 8-2 | 51-45 | 3 | 38,181 | John Lackey | Jamie Moyer | John Lackey | Jamie Moyer | | 497 | 445 | 52 |
| 2004-07-24 | @ SEA | 97 | W 8-4 | 52-45 | 3 | 44,514 | Aaron Sele | Ron Villone | Aaron Sele | Julio Mateo | | 505 | 449 | 56 |
| 2004-07-25 | @ SEA | 98 | L 2-6 | 52-46 | 3 | 45,099 | Ramon Ortiz | Joel Pineiro | Joel Pineiro | Ramon Ortiz | | 507 | 455 | 52 |
| 2004-07-26 | vs TEX | 99 | L 1-6 | 52-47 | 3 | 42,040 | Kelvim Escobar | Ryan Drese | Ryan Drese | Kelvim Escobar | | 508 | 461 | 47 |
| 2004-07-27 | vs TEX | 100 | W 2-0 | 53-47 | 3 | 42,625 | Bartolo Colon | Nick Regilio | Bartolo Colon | Nick Regilio | Troy Percival | 510 | 461 | 49 |
| 2004-07-28 | vs TEX | 101 | W 2-0 | 54-47 | 3 | 41,133 | John Lackey | Kenny Rogers | John Lackey | Kenny Rogers | Troy Percival | 512 | 461 | 51 |
| 2004-07-29 | vs SEA | 102 | L 5-6 | 54-48 | 3 | 43,033 | Aaron Sele | Ron Villone | Bobby Madritsch | Kevin Gregg | | 517 | 467 | 50 |
| 2004-07-30 | vs SEA | 103 | W 6-5 | 55-48 | 3 | 43,635 | Ramon Ortiz | Gil Meche | Brendan Donnelly | J.J. Putz | Troy Percival | 523 | 472 | 51 |
| 2004-07-31 | vs SEA | 104 | W 9-8 | 56-48 | 3 | 43,576 | Kelvim Escobar | Travis Blackley | Brendan Donnelly | Eddie Guardado | | 532 | 480 | 52 |
| 2004-08-01 | vs SEA | 105 | W 3-2 | 57-48 | 3 | 43,412 | Bartolo Colon | Ryan Franklin | Bartolo Colon | Ryan Franklin | Scot Shields | 535 | 482 | 53 |
| 2004-08-03 | @ MIN | 106 | L 0-10 | 57-49 | 3 | 22,273 | John Lackey | Carlos Silva | Carlos Silva | John Lackey | | 535 | 492 | 43 |
| 2004-08-04 | @ MIN | 107 | L 3-6 | 57-50 | 3 | 28,435 | Ramon Ortiz | Kyle Lohse | Kyle Lohse | Ramon Ortiz | Joe Nathan | 538 | 498 | 40 |
| 2004-08-05 | @ MIN | 108 | W 8-3 | 58-50 | 3 | 26,867 | Aaron Sele | Terry Mulholland | Aaron Sele | Terry Mulholland | | 546 | 501 | 45 |
| 2004-08-06 | @ KCA | 109 | W 3-0 | 59-50 | 3 | 20,572 | Kelvim Escobar | Darrell May | Kelvim Escobar | Darrell May | Troy Percival | 549 | 501 | 48 |
| 2004-08-07 | @ KCA | 110 | W 7-5 | 60-50 | 3 | 27,046 | Bartolo Colon | Jimmy Serrano | Bartolo Colon | Dennys Reyes | Troy Percival | 556 | 506 | 50 |
| 2004-08-08 | @ KCA | 111 | W 6-4 | 61-50 | 3 | 18,366 | John Lackey | Mike Wood | Brendan Donnelly | Nate Field | Francisco Rodriguez | 562 | 510 | 52 |
| 2004-08-09 | @ KCA | 112 | W 5-3 | 62-50 | 2 | 16,262 | Ramon Ortiz | Brian Anderson | Kevin Gregg | Jaime Cerda | Troy Percival | 567 | 513 | 54 |
| 2004-08-10 | vs BAL | 113 | L 3-11 | 62-51 | 3 | 43,068 | Aaron Sele | Daniel Cabrera | Daniel Cabrera | Aaron Sele | | 570 | 524 | 46 |
| 2004-08-11 | vs BAL | 114 | W 4-2 | 63-51 | 2 | 41,446 | Kelvim Escobar | Erik Bedard | Kelvim Escobar | Jason Grimsley | Troy Percival | 574 | 526 | 48 |
| 2004-08-12 | vs BAL | 115 | L 1-6 | 63-52 | 2 | 41,467 | Bartolo Colon | Rodrigo Lopez | Rodrigo Lopez | Bartolo Colon | | 575 | 532 | 43 |
| 2004-08-13 | vs DET | 116 | L 3-5 | 63-53 | 3 | 43,580 | John Lackey | Jeremy Bonderman | Esteban Yan | Troy Percival | Ugueth Urbina | 578 | 537 | 41 |
| 2004-08-14 | vs DET | 117 | W 11-8 | 64-53 | 3 | 43,545 | Ramon Ortiz | Nate Robertson | Kevin Gregg | Roberto Novoa | Francisco Rodriguez | 589 | 545 | 44 |
| 2004-08-15 | vs DET | 118 | W 3-2 | 65-53 | 3 | 42,850 | Aaron Sele | Jason Johnson | Scot Shields | Jason Johnson | Troy Percival | 592 | 547 | 45 |
| 2004-08-17 | @ TBA | 119 | L 3-8 | 65-54 | 3 | 9,537 | Kelvim Escobar | Dewon Brazelton | Dewon Brazelton | Kelvim Escobar | | 595 | 555 | 40 |
| 2004-08-18 | @ TBA | 120 | W 6-4 | 66-54 | 3 | 10,731 | Bartolo Colon | Mark Hendrickson | Bartolo Colon | Mark Hendrickson | | 601 | 559 | 42 |
| 2004-08-19 | @ TBA | 121 | W 10-7 | 67-54 | 3 | 9,720 | John Lackey | Rob Bell | John Lackey | Rob Bell | Francisco Rodriguez | 611 | 566 | 45 |
| 2004-08-20 | @ NYA | 122 | W 5-0 | 68-54 | 3 | 53,530 | Ramon Ortiz | Jon Lieber | Ramon Ortiz | Jon Lieber | | 616 | 566 | 50 |
| 2004-08-21 | @ NYA | 123 | W 6-1 | 69-54 | 3 | 54,008 | Aaron Sele | Esteban Loaiza | Scot Shields | Esteban Loaiza | | 622 | 567 | 55 |
| 2004-08-22 | @ NYA | 124 | W 4-3 | 70-54 | 3 | 53,885 | Kelvim Escobar | Kevin Brown | Kelvim Escobar | Kevin Brown | Troy Percival | 626 | 570 | 56 |
| 2004-08-23 | vs KCA | 125 | W 9-4 | 71-54 | 2 | 40,717 | Bartolo Colon | Darrell May | Bartolo Colon | Darrell May | | 635 | 574 | 61 |
| 2004-08-24 | vs KCA | 126 | W 7-5 | 72-54 | 2 | 40,183 | John Lackey | Jimmy Serrano | John Lackey | Dennys Reyes | Troy Percival | 642 | 579 | 63 |
| 2004-08-25 | vs KCA | 127 | W 21-6 | 73-54 | 2 | 39,657 | Ramon Ortiz | Mike Wood | Ramon Ortiz | Mike Wood | | 663 | 585 | 78 |
| 2004-08-27 | vs MIN | 128 | W 9-6 | 74-54 | 2 | 43,634 | Aaron Sele | Brad Radke | Aaron Sele | Brad Radke | Troy Percival | 672 | 591 | 81 |
| 2004-08-28 | vs MIN | 129 | L 1-7 | 74-55 | 2 | 42,778 | Bartolo Colon | Johan Santana | Johan Santana | Bartolo Colon | | 673 | 598 | 75 |
| 2004-08-29 | vs MIN | 130 | W 4-2 | 75-55 | 2 | 43,193 | Kelvim Escobar | Carlos Silva | Francisco Rodriguez | Juan Rincon | | 677 | 600 | 77 |
| 2004-08-31 | @ BOS | 131 | L 7-10 | 75-56 | 2 | 35,040 | John Lackey | Curt Schilling | Curt Schilling | John Lackey | Keith Foulke | 684 | 610 | 74 |
| 2004-09-01 | @ BOS | 132 | L 7-12 | 75-57 | 2 | 35,076 | Aaron Sele | Bronson Arroyo | Terry Adams | Aaron Sele | | 691 | 622 | 69 |
| 2004-09-02 | @ BOS | 133 | L 3-4 | 75-58 | 2 | 35,050 | Bartolo Colon | Derek Lowe | Derek Lowe | Bartolo Colon | Keith Foulke | 694 | 626 | 68 |
| 2004-09-03 | @ CLE | 134 | W 10-5 | 76-58 | 2 | 20,994 | Kelvim Escobar | Scott Elarton | Kelvim Escobar | Scott Elarton | | 704 | 631 | 73 |
| 2004-09-04 | @ CLE | 135 | W 6-1 | 77-58 | 2 | 23,786 | Jarrod Washburn | Jason Davis | Jarrod Washburn | Jason Davis | | 710 | 632 | 78 |
| 2004-09-05 | @ CLE | 136 | W 2-1 | 78-58 | 2 | 26,208 | John Lackey | Jake Westbrook | John Lackey | Jake Westbrook | Francisco Rodriguez | 712 | 633 | 79 |
| 2004-09-07 | vs TOR | 137 | W 5-2 | 79-58 | 2 | 36,277 | Bartolo Colon | David Bush | Bartolo Colon | David Bush | Troy Percival | 717 | 635 | 82 |
| 2004-09-08 | vs TOR | 138 | L 0-1 | 79-59 | 2 | 36,905 | Kelvim Escobar | Justin Miller | Justin Miller | Kelvim Escobar | Justin Speier | 717 | 636 | 81 |
| 2004-09-09 | vs TOR | 139 | L 4-5 | 79-60 | 2 | 37,514 | Jarrod Washburn | Ted Lilly | Ted Lilly | Jarrod Washburn | Justin Speier | 721 | 641 | 80 |
| 2004-09-10 | vs CHA | 140 | W 7-5 | 80-60 | 2 | 42,431 | John Lackey | Jon Garland | Francisco Rodriguez | Jeff Bajenaru | Troy Percival | 728 | 646 | 82 |
| 2004-09-11 | vs CHA | 141 | L 6-13 | 80-61 | 2 | 42,568 | Aaron Sele | Jason Grilli | Jason Grilli | Aaron Sele | | 734 | 659 | 75 |
| 2004-09-12 | vs CHA | 142 | W 11-0 | 81-61 | 2 | 41,932 | Bartolo Colon | Jose Contreras | Bartolo Colon | Jose Contreras | | 745 | 659 | 86 |
| 2004-09-13 | @ SEA | 143 | W 5-1 | 82-61 | 2 | 30,432 | Kelvim Escobar | Cha-Seung Baek | Kelvim Escobar | Cha-Seung Baek | Francisco Rodriguez | 750 | 660 | 90 |
| 2004-09-14 | @ SEA | 144 | L 2-3 | 82-62 | 2 | 28,408 | Jarrod Washburn | Bobby Madritsch | Bobby Madritsch | Jarrod Washburn | J.J. Putz | 752 | 663 | 89 |
| 2004-09-15 | @ SEA | 145 | L 0-1 | 82-63 | 2 | 31,269 | John Lackey | Ryan Franklin | Ryan Franklin | John Lackey | | 752 | 664 | 88 |
| 2004-09-16 | @ SEA | 146 | W 6-1 | 83-63 | 2 | 28,497 | Aaron Sele | Jamie Moyer | Aaron Sele | Jamie Moyer | | 758 | 665 | 93 |
| 2004-09-17 | vs TEX | 147 | W 9-5 | 84-63 | 2 | 43,343 | Bartolo Colon | Chan Ho Park | Bartolo Colon | Chan Ho Park | | 767 | 670 | 97 |
| 2004-09-18 | vs TEX | 148 | L 0-2 | 84-64 | 2 | 41,233 | Kelvim Escobar | Joaquin Benoit | Erasmo Ramirez | Kelvim Escobar | Francisco Cordero | 767 | 672 | 95 |
| 2004-09-19 | vs TEX | 149 | L 0-1 | 84-65 | 2 | 40,099 | Jarrod Washburn | Chris Young | Chris Young | Jarrod Washburn | Francisco Cordero | 767 | 673 | 94 |
| 2004-09-20 | vs SEA | 150 | W 5-2 | 85-65 | 2 | 39,074 | John Lackey | Ryan Franklin | John Lackey | Ryan Franklin | Troy Percival | 772 | 675 | 97 |
| 2004-09-21 | vs SEA | 151 | L 3-7 | 85-66 | 2 | 42,251 | Aaron Sele | Jamie Moyer | Jamie Moyer | Aaron Sele | | 775 | 682 | 93 |
| 2004-09-22 | vs SEA | 152 | L 6-16 | 85-67 | 2 | 37,015 | Bartolo Colon | Gil Meche | Gil Meche | Bartolo Colon | | 781 | 698 | 83 |
| 2004-09-24 | vs OAK | 153 | L 3-6 | 85-68 | 2 | 43,503 | Kelvim Escobar | Rich Harden | Rich Harden | Kelvim Escobar | | 784 | 704 | 80 |
| 2004-09-25 | vs OAK | 154 | W 5-3 | 86-68 | 2 | 43,197 | Jarrod Washburn | Mark Redman | Francisco Rodriguez | Chad Bradford | Troy Percival | 789 | 707 | 82 |
| 2004-09-26 | vs OAK | 155 | W 6-2 | 87-68 | 2 | 43,512 | John Lackey | Mark Mulder | John Lackey | Mark Mulder | | 795 | 709 | 86 |
| 2004-09-27 | @ TEX | 156 | W 5-3 | 88-68 | 2 | 20,333 | Bartolo Colon | Kenny Rogers | Bartolo Colon | Kenny Rogers | Troy Percival | 800 | 712 | 88 |
| 2004-09-28 | @ TEX | 157 | W 8-2 | 89-68 | 1 | 26,686 | Kelvim Escobar | Chan Ho Park | Kelvim Escobar | Chan Ho Park | | 808 | 714 | 94 |
| 2004-09-29 | @ TEX | 158 | W 8-7 | 90-68 | 1 | 31,538 | Jarrod Washburn | Kameron Loe | Scot Shields | Francisco Cordero | Troy Percival | 816 | 721 | 95 |
| 2004-09-30 | @ TEX | 159 | L 3-6 | 90-69 | 1 | 23,036 | John Lackey | Chris Young | Chris Young | John Lackey | R.A. Dickey | 819 | 727 | 92 |
| 2004-10-01 | @ OAK | 160 | W 10-0 | 91-69 | 1 | 47,081 | Bartolo Colon | Mark Mulder | Bartolo Colon | Mark Mulder | | 829 | 727 | 102 |
| 2004-10-02 | @ OAK | 161 | W 5-4 | 92-69 | 1 | 42,832 | Kelvim Escobar | Barry Zito | Brendan Donnelly | Ricardo Rincon | Troy Percival | 834 | 731 | 103 |
| 2004-10-03 | @ OAK | 162 | L 2-3 | 92-70 | 1 | 33,640 | Aaron Sele | Tim Hudson | Justin Duchscherer | Kevin Gregg | | 836 | 734 | 102 |