| 2003-03-31 | @ BAL | 1 | L 5-6 | 0-1 | 4 | 46,257 | CC Sabathia | Rodrigo Lopez | B.J. Ryan | Jake Westbrook | | 5 | 6 | -1 |
| 2003-04-02 | @ BAL | 2 | W 4-2 | 1-1 | 3 | 27,658 | Ricardo Rodriguez | Omar Daal | Ricardo Rodriguez | Omar Daal | Danys Baez | 9 | 8 | 1 |
| 2003-04-03 | @ BAL | 3 | W 3-0 | 2-1 | 3 | 18,470 | Brian Anderson | Rick Helling | Brian Anderson | Rick Helling | Danys Baez | 12 | 8 | 4 |
| 2003-04-04 | @ KCA | 4 | L 1-5 | 2-2 | 3 | 15,241 | Jason Davis | Chris George | Chris George | Jason Davis | | 13 | 13 | 0 |
| 2003-04-05 | @ KCA | 5 | L 1-3 | 2-3 | 4 | 19,912 | CC Sabathia | Runelvys Hernandez | Runelvys Hernandez | CC Sabathia | Mike MacDougal | 14 | 16 | -2 |
| 2003-04-08 | vs CHA | 6 | L 3-5 | 2-4 | 4 | 42,301 | Ricardo Rodriguez | Bartolo Colon | Billy Koch | Chad Paronto | | 17 | 21 | -4 |
| 2003-04-09 | vs CHA | 7 | W 5-2 | 3-4 | 3 | 14,841 | Brian Anderson | Jon Garland | Brian Anderson | Jon Garland | Danys Baez | 22 | 23 | -1 |
| 2003-04-10 | vs CHA | 8 | L 2-7 | 3-5 | 3 | 15,916 | Jason Davis | Mark Buehrle | Mark Buehrle | Jason Davis | | 24 | 30 | -6 |
| 2003-04-11 | vs KCA | 9 | L 0-1 | 3-6 | 4 | 17,931 | Jake Westbrook | Runelvys Hernandez | Runelvys Hernandez | Jake Westbrook | Mike MacDougal | 24 | 31 | -7 |
| 2003-04-12 | vs KCA | 10 | L 2-5 | 3-7 | 4 | 18,168 | CC Sabathia | Chris George | Chris George | CC Sabathia | D.J. Carrasco | 26 | 36 | -10 |
| 2003-04-13 | vs KCA | 11 | W 6-1 | 4-7 | 4 | 19,335 | Ricardo Rodriguez | Darrell May | Ricardo Rodriguez | Darrell May | | 32 | 37 | -5 |
| 2003-04-14 | vs KCA | 12 | L 4-12 | 4-8 | 4 | 15,875 | Brian Anderson | Jeremy Affeldt | Jeremy Affeldt | Brian Anderson | | 36 | 49 | -13 |
| 2003-04-15 | vs BAL | 13 | W 8-3 | 5-8 | 4 | 17,015 | Jason Davis | Omar Daal | Jason Davis | Omar Daal | | 44 | 52 | -8 |
| 2003-04-16 | vs BAL | 14 | L 3-4 | 5-9 | 4 | 15,674 | Jake Westbrook | Rick Helling | Buddy Groom | Danys Baez | Jorge Julio | 47 | 56 | -9 |
| 2003-04-17 | vs BAL | 15 | L 4-6 | 5-10 | 4 | 17,368 | CC Sabathia | Sidney Ponson | Willis Roberts | Chad Paronto | Jorge Julio | 51 | 62 | -11 |
| 2003-04-18 | @ CHA | 16 | L 3-5 | 5-11 | 4 | 13,015 | Ricardo Rodriguez | Bartolo Colon | Bartolo Colon | Billy Traber | | 54 | 67 | -13 |
| 2003-04-19 | @ CHA | 17 | L 3-12 | 5-12 | 4 | 18,907 | Brian Anderson | Josh Stewart | Josh Stewart | Brian Anderson | | 57 | 79 | -22 |
| 2003-04-20 | @ CHA | 18 | W 7-4 | 6-12 | 4 | 14,975 | Jason Davis | Mark Buehrle | Jason Davis | Mark Buehrle | | 64 | 83 | -19 |
| 2003-04-21 | @ CHA | 19 | W 9-2 | 7-12 | 4 | 15,424 | Jake Westbrook | Jon Garland | Jake Westbrook | Jon Garland | | 73 | 85 | -12 |
| 2003-04-22 | @ SEA | 20 | L 5-8 | 7-13 | 4 | 25,231 | CC Sabathia | Freddy Garcia | Giovanni Carrara | Danys Baez | | 78 | 93 | -15 |
| 2003-04-23 | @ SEA | 21 | L 0-4 | 7-14 | 4 | 26,036 | Ricardo Rodriguez | Gil Meche | Gil Meche | Ricardo Rodriguez | | 78 | 97 | -19 |
| 2003-04-24 | @ SEA | 22 | L 2-4 | 7-15 | 4 | 26,263 | Billy Traber | Jamie Moyer | Jamie Moyer | Billy Traber | Jeff Nelson | 80 | 101 | -21 |
| 2003-04-25 | @ OAK | 23 | L 2-5 | 7-16 | 4 | 11,178 | Jason Davis | Ted Lilly | Ted Lilly | Jason Davis | Keith Foulke | 82 | 106 | -24 |
| 2003-04-26 | @ OAK | 24 | L 3-6 | 7-17 | 4 | 36,346 | Jake Westbrook | John Halama | Chad Bradford | Terry Mulholland | Keith Foulke | 85 | 112 | -27 |
| 2003-04-27 | @ OAK | 25 | L 3-4 | 7-18 | 4 | 26,414 | CC Sabathia | Tim Hudson | Ricardo Rincon | Danys Baez | | 88 | 116 | -28 |
| 2003-04-29 | vs ANA | 26 | L 1-10 | 7-19 | 4 | 16,667 | Ricardo Rodriguez | Ramon Ortiz | Ramon Ortiz | Ricardo Rodriguez | | 89 | 126 | -37 |
| 2003-04-30 | vs ANA | 27 | L 2-6 | 7-20 | 4 | 15,761 | Brian Anderson | Jarrod Washburn | Jarrod Washburn | Brian Anderson | | 91 | 132 | -41 |
| 2003-05-02 | vs TEX | 28 | W 6-5 | 8-20 | 4 | 19,823 | Jason Davis | Joaquin Benoit | Dave Elder | Francisco Cordero | Danys Baez | 97 | 137 | -40 |
| 2003-05-03 | vs TEX | 29 | L 5-6 | 8-21 | 4 | 23,030 | Jake Westbrook | Todd Van Poppel | Jay Powell | Jose Santiago | Ugueth Urbina | 102 | 143 | -41 |
| 2003-05-04 | vs TEX | 30 | W 3-1 | 9-21 | 4 | 20,866 | CC Sabathia | John Thomson | CC Sabathia | John Thomson | Danys Baez | 105 | 144 | -39 |
| 2003-05-06 | @ ANA | 31 | L 1-6 | 9-22 | 4 | 25,043 | Ricardo Rodriguez | Jarrod Washburn | Jarrod Washburn | Ricardo Rodriguez | | 106 | 150 | -44 |
| 2003-05-07 | @ ANA | 32 | L 5-6 | 9-23 | 4 | 24,063 | Brian Anderson | John Lackey | Scot Shields | Dave Elder | Troy Percival | 111 | 156 | -45 |
| 2003-05-08 | @ ANA | 33 | L 1-7 | 9-24 | 4 | 27,957 | Jason Davis | Kevin Appier | Kevin Appier | Jason Davis | | 112 | 163 | -51 |
| 2003-05-09 | @ TEX | 34 | W 9-5 | 10-24 | 4 | 25,106 | Jake Westbrook | John Thomson | Jake Westbrook | John Thomson | | 121 | 168 | -47 |
| 2003-05-10 | @ TEX | 35 | W 6-4 | 11-24 | 4 | 43,484 | CC Sabathia | Alan Benes | CC Sabathia | Alan Benes | Danys Baez | 127 | 172 | -45 |
| 2003-05-11 | @ TEX | 36 | L 10-17 | 11-25 | 4 | 23,407 | Ricardo Rodriguez | Colby Lewis | Joaquin Benoit | Ricardo Rodriguez | | 137 | 189 | -52 |
| 2003-05-13 | vs SEA | 37 | L 3-8 | 11-26 | 4 | 16,721 | Brian Anderson | Joel Pineiro | Joel Pineiro | Brian Anderson | | 140 | 197 | -57 |
| 2003-05-14 | vs SEA | 38 | W 7-2 | 12-26 | 4 | 17,324 | Jason Davis | Freddy Garcia | Jason Davis | Freddy Garcia | | 147 | 199 | -52 |
| 2003-05-15 | vs SEA | 39 | L 1-9 | 12-27 | 4 | 17,889 | Jake Westbrook | Ryan Franklin | Giovanni Carrara | Jake Westbrook | | 148 | 208 | -60 |
| 2003-05-16 | vs OAK | 40 | W 3-2 | 13-27 | 4 | 22,357 | CC Sabathia | Mark Mulder | Billy Traber | Mark Mulder | Danys Baez | 151 | 210 | -59 |
| 2003-05-17 | vs OAK | 41 | W 4-2 | 14-27 | 4 | 23,958 | Ricardo Rodriguez | John Halama | Terry Mulholland | Ricardo Rincon | Danys Baez | 155 | 212 | -57 |
| 2003-05-18 | vs OAK | 42 | L 5-8 | 14-28 | 4 | 25,421 | Brian Anderson | Ted Lilly | Keith Foulke | Danys Baez | | 160 | 220 | -60 |
| 2003-05-19 | vs DET | 43 | W 10-9 | 15-28 | 4 | 16,492 | Jason Davis | Gary Knotts | Billy Traber | Jamie Walker | David Riske | 170 | 229 | -59 |
| 2003-05-20 | vs DET | 44 | W 6-4 | 16-28 | 4 | 15,499 | Jake Westbrook | Adam Bernero | David Riske | Matt Roney | | 176 | 233 | -57 |
| 2003-05-21 | vs DET | 45 | W 4-0 | 17-28 | 4 | 16,534 | CC Sabathia | Jeremy Bonderman | CC Sabathia | Jeremy Bonderman | | 180 | 233 | -53 |
| 2003-05-22 | vs DET | 46 | L 2-3 | 17-29 | 4 | 18,347 | Jason Bere | Nate Cornejo | Franklyn German | Jason Phillips | Steve Sparks | 182 | 236 | -54 |
| 2003-05-23 | @ BOS | 47 | L 2-9 | 17-30 | 4 | 32,673 | Ricardo Rodriguez | Derek Lowe | Derek Lowe | Ricardo Rodriguez | | 184 | 245 | -61 |
| 2003-05-24 | @ BOS | 48 | L 3-12 | 17-31 | 4 | 32,643 | Brian Anderson | John Burkett | John Burkett | Brian Anderson | | 187 | 257 | -70 |
| 2003-05-25 | @ BOS | 49 | W 6-4 | 18-31 | 4 | 34,318 | Jason Davis | Casey Fossum | Jason Davis | Casey Fossum | Danys Baez | 193 | 261 | -68 |
| 2003-05-26 | @ DET | 50 | L 5-6 | 18-32 | 4 | 17,619 | Jake Westbrook | Jeremy Bonderman | Steve Avery | Jason Boyd | Franklyn German | 198 | 267 | -69 |
| 2003-05-27 | @ DET | 51 | W 5-2 | 19-32 | 4 | 10,844 | Jason Bere | Nate Cornejo | Dan Miceli | Jamie Walker | Danys Baez | 203 | 269 | -66 |
| 2003-05-28 | @ DET | 52 | W 8-2 | 20-32 | 4 | 17,388 | Ricardo Rodriguez | Mike Maroth | Ricardo Rodriguez | Mike Maroth | | 211 | 271 | -60 |
| 2003-05-30 | vs CHA | 53 | W 7-3 | 21-32 | 4 | 24,666 | CC Sabathia | Dan Wright | CC Sabathia | Dan Wright | | 218 | 274 | -56 |
| 2003-06-01 | vs CHA | 54 | W 5-4 | 22-32 | 4 | 22,681 | Jason Davis | Mark Buehrle | Jason Boyd | Billy Koch | | 223 | 278 | -55 |
| 2003-06-02 | vs CHA | 55 | W 5-2 | 23-32 | 4 | 20,892 | Brian Anderson | Bartolo Colon | Brian Anderson | Bartolo Colon | Danys Baez | 228 | 280 | -52 |
| 2003-06-03 | @ COL | 56 | L 3-7 | 23-33 | 4 | 22,326 | Ricardo Rodriguez | Scott Elarton | Scott Elarton | Ricardo Rodriguez | | 231 | 287 | -56 |
| 2003-06-04 | @ COL | 57 | L 1-2 | 23-34 | 4 | 22,222 | Billy Traber | Darren Oliver | Darren Oliver | Billy Traber | Jose Jimenez | 232 | 289 | -57 |
| 2003-06-05 | @ COL | 58 | L 4-7 | 23-35 | 4 | 25,221 | CC Sabathia | Jason Jennings | Jason Jennings | CC Sabathia | Jose Jimenez | 236 | 296 | -60 |
| 2003-06-06 | @ ARI | 59 | W 6-3 | 24-35 | 4 | 32,430 | Jason Davis | Edgar Gonzalez | Jason Davis | Edgar Gonzalez | Danys Baez | 242 | 299 | -57 |
| 2003-06-07 | @ ARI | 60 | L 3-5 | 24-36 | 4 | 36,619 | Brian Anderson | John Patterson | Steve Randolph | Brian Anderson | Jose Valverde | 245 | 304 | -59 |
| 2003-06-08 | @ ARI | 61 | L 3-13 | 24-37 | 4 | 42,956 | Ricardo Rodriguez | Brandon Webb | Brandon Webb | Ricardo Rodriguez | | 248 | 317 | -69 |
| 2003-06-10 | vs SDN | 62 | W 8-5 | 25-37 | 4 | 19,949 | Billy Traber | Brian Tollberg | Jake Westbrook | Brian Tollberg | Danys Baez | 256 | 322 | -66 |
| 2003-06-11 | vs SDN | 63 | W 3-2 | 26-37 | 4 | 17,427 | CC Sabathia | Adam Eaton | CC Sabathia | Adam Eaton | Danys Baez | 259 | 324 | -65 |
| 2003-06-12 | vs SDN | 64 | L 4-9 | 26-38 | 4 | 17,983 | Jason Davis | Jake Peavy | Jake Peavy | Jason Davis | | 263 | 333 | -70 |
| 2003-06-13 | vs LAN | 65 | L 3-4 | 26-39 | 4 | 23,401 | Brian Anderson | Odalis Perez | Paul Quantrill | Jake Westbrook | Eric Gagne | 266 | 337 | -71 |
| 2003-06-14 | vs LAN | 66 | L 2-5 | 26-40 | 4 | 25,426 | Brian Tallet | Andy Ashby | Andy Ashby | Brian Tallet | Wilson Alvarez | 268 | 342 | -74 |
| 2003-06-15 | vs LAN | 67 | L 3-4 | 26-41 | 4 | 26,786 | Billy Traber | Hideo Nomo | Hideo Nomo | Billy Traber | Eric Gagne | 271 | 346 | -75 |
| 2003-06-17 | @ DET | 68 | W 7-4 | 27-41 | 4 | 13,908 | CC Sabathia | Adam Bernero | CC Sabathia | Adam Bernero | Danys Baez | 278 | 350 | -72 |
| 2003-06-18 | @ DET | 69 | W 4-1 | 28-41 | 4 | 16,278 | Jason Davis | Jeremy Bonderman | Jason Davis | Jeremy Bonderman | | 282 | 351 | -69 |
| 2003-06-19 | @ DET | 70 | W 10-3 | 29-41 | 4 | 19,098 | Brian Anderson | Nate Cornejo | Brian Anderson | Nate Cornejo | | 292 | 354 | -62 |
| 2003-06-20 | @ PIT | 71 | L 4-5 | 29-42 | 4 | 26,305 | Brian Tallet | Josh Fogg | Salomon Torres | Danys Baez | | 296 | 359 | -63 |
| 2003-06-21 | @ PIT | 72 | L 6-7 | 29-43 | 4 | 36,856 | Billy Traber | Kris Benson | Scott Sauerbeck | Dan Miceli | | 302 | 366 | -64 |
| 2003-06-22 | @ PIT | 73 | W 8-5 | 30-43 | 4 | 37,803 | CC Sabathia | Ryan Vogelsong | CC Sabathia | Ryan Vogelsong | Danys Baez | 310 | 371 | -61 |
| 2003-06-24 | vs KCA | 74 | L 1-3 | 30-44 | 4 | 19,638 | Jason Davis | Chris George | Chris George | Jason Davis | Mike MacDougal | 311 | 374 | -63 |
| 2003-06-25 | vs KCA | 75 | L 1-3 | 30-45 | 4 | 18,527 | Brian Anderson | Kyle Snyder | Jason Gilfillan | David Riske | Mike MacDougal | 312 | 377 | -65 |
| 2003-06-26 | vs KCA | 76 | L 1-4 | 30-46 | 4 | 17,494 | Ricardo Rodriguez | Jose Lima | Jose Lima | Ricardo Rodriguez | Mike MacDougal | 313 | 381 | -68 |
| 2003-06-27 | vs CIN | 77 | W 3-0 | 31-46 | 4 | 29,233 | Billy Traber | Danny Graves | Billy Traber | Danny Graves | Danys Baez | 316 | 381 | -65 |
| 2003-06-28 | vs CIN | 78 | L 4-5 | 31-47 | 4 | 31,924 | CC Sabathia | Ryan Dempster | Chris Reitsma | Danys Baez | Scott Williamson | 320 | 386 | -66 |
| 2003-06-29 | vs CIN | 79 | W 3-1 | 32-47 | 4 | 28,433 | Jason Davis | Jimmy Haynes | Jason Davis | Jimmy Haynes | Danys Baez | 323 | 387 | -64 |
| 2003-06-30 | @ KCA | 80 | W 10-5 | 34-47 | 4 | 0 | Cliff Lee | Brad Voyles | Cliff Lee | Brad Voyles | | 333 | 392 | -59 |
| 2003-06-30 | @ KCA | 81 | W 8-5 | 34-47 | 4 | 14,645 | Brian Anderson | Kyle Snyder | Brian Anderson | Les Walrond | Danys Baez | 341 | 397 | -56 |
| 2003-07-01 | @ KCA | 82 | L 3-6 | 34-48 | 4 | 12,831 | Ricardo Rodriguez | Jose Lima | Jose Lima | Ricardo Rodriguez | Mike MacDougal | 344 | 403 | -59 |
| 2003-07-02 | @ KCA | 83 | L 2-8 | 34-49 | 4 | 12,918 | Billy Traber | Darrell May | Darrell May | Billy Traber | | 346 | 411 | -65 |
| 2003-07-03 | @ MIN | 84 | W 4-1 | 35-49 | 4 | 15,064 | CC Sabathia | Kenny Rogers | CC Sabathia | Kenny Rogers | | 350 | 412 | -62 |
| 2003-07-04 | @ MIN | 85 | L 2-9 | 35-50 | 4 | 21,328 | Jason Davis | Rick Reed | Rick Reed | Jason Davis | | 352 | 421 | -69 |
| 2003-07-05 | @ MIN | 86 | W 13-2 | 36-50 | 4 | 20,273 | Brian Anderson | Joe Mays | Brian Anderson | Joe Mays | | 365 | 423 | -58 |
| 2003-07-06 | @ MIN | 87 | W 5-3 | 37-50 | 4 | 20,549 | Jason Stanford | Brad Radke | David Riske | Eddie Guardado | Danys Baez | 370 | 426 | -56 |
| 2003-07-08 | vs NYA | 88 | W 4-0 | 38-50 | 4 | 26,540 | Billy Traber | Jeff Weaver | Billy Traber | Jeff Weaver | | 374 | 426 | -52 |
| 2003-07-09 | vs NYA | 89 | L 2-6 | 38-51 | 4 | 25,058 | CC Sabathia | David Wells | David Wells | CC Sabathia | | 376 | 432 | -56 |
| 2003-07-10 | vs NYA | 90 | W 3-2 | 39-51 | 4 | 30,167 | Jason Davis | Roger Clemens | Jason Boyd | Sterling Hitchcock | | 379 | 434 | -55 |
| 2003-07-11 | vs CHA | 91 | W 12-5 | 40-51 | 4 | 27,712 | Brian Anderson | Dan Wright | Brian Anderson | Dan Wright | | 391 | 439 | -48 |
| 2003-07-12 | vs CHA | 92 | L 4-7 | 41-52 | 4 | 24,163 | Jason Stanford | Mark Buehrle | Damaso Marte | Terry Mulholland | Tom Gordon | 395 | 446 | -51 |
| 2003-07-12 | vs CHA | 93 | W 4-2 | 41-52 | 4 | 27,165 | Jake Westbrook | Mike Porzio | Jake Westbrook | Mike Porzio | Danys Baez | 399 | 448 | -49 |
| 2003-07-13 | vs CHA | 94 | L 4-7 | 41-53 | 4 | 26,467 | Billy Traber | Jon Garland | Damaso Marte | Rafael Betancourt | Tom Gordon | 403 | 455 | -52 |
| 2003-07-17 | @ NYA | 95 | L 4-5 | 41-54 | 4 | 46,401 | Jason Davis | Andy Pettitte | Mariano Rivera | David Riske | | 407 | 460 | -53 |
| 2003-07-18 | @ NYA | 96 | L 4-10 | 41-55 | 4 | 47,341 | Brian Anderson | Roger Clemens | Roger Clemens | Brian Anderson | | 411 | 470 | -59 |
| 2003-07-19 | @ NYA | 97 | L 4-7 | 41-56 | 4 | 54,981 | CC Sabathia | David Wells | David Wells | CC Sabathia | Mariano Rivera | 415 | 477 | -62 |
| 2003-07-20 | @ NYA | 98 | L 4-7 | 41-57 | 4 | 51,891 | Jake Westbrook | Mike Mussina | Mike Mussina | Jake Westbrook | Mariano Rivera | 419 | 484 | -65 |
| 2003-07-21 | @ CHA | 99 | L 3-4 | 41-58 | 4 | 31,776 | Brian Tallet | Mike Porzio | Mike Porzio | Brian Tallet | Tom Gordon | 422 | 488 | -66 |
| 2003-07-22 | @ CHA | 100 | L 2-5 | 41-59 | 4 | 20,667 | Jason Davis | Bartolo Colon | Bartolo Colon | Jason Davis | Damaso Marte | 424 | 493 | -69 |
| 2003-07-23 | vs DET | 101 | W 4-1 | 42-59 | 4 | 21,202 | Brian Anderson | Matt Roney | Brian Anderson | Matt Roney | Danys Baez | 428 | 494 | -66 |
| 2003-07-24 | vs DET | 102 | L 4-7 | 42-60 | 4 | 20,857 | CC Sabathia | Nate Cornejo | Nate Cornejo | CC Sabathia | Chris Mears | 432 | 501 | -69 |
| 2003-07-25 | vs MIN | 103 | L 5-6 | 42-61 | 4 | 23,444 | Jake Westbrook | Kenny Rogers | LaTroy Hawkins | Danys Baez | Eddie Guardado | 437 | 507 | -70 |
| 2003-07-26 | vs MIN | 104 | W 9-2 | 43-61 | 4 | 25,077 | Billy Traber | Kyle Lohse | Billy Traber | Kyle Lohse | | 446 | 509 | -63 |
| 2003-07-27 | vs MIN | 105 | W 3-2 | 44-61 | 4 | 24,318 | Jason Davis | Rick Reed | Rafael Betancourt | Juan Rincon | | 449 | 511 | -62 |
| 2003-07-29 | @ OAK | 106 | L 2-6 | 44-62 | 4 | 19,260 | Brian Anderson | Mark Mulder | Mark Mulder | Brian Anderson | Keith Foulke | 451 | 517 | -66 |
| 2003-07-30 | @ OAK | 107 | W 4-2 | 45-62 | 4 | 29,792 | CC Sabathia | Ted Lilly | CC Sabathia | Ted Lilly | Danys Baez | 455 | 519 | -64 |
| 2003-07-31 | @ OAK | 108 | L 1-3 | 45-63 | 4 | 25,011 | Jake Westbrook | Rich Harden | Rich Harden | Jake Westbrook | Keith Foulke | 456 | 522 | -66 |
| 2003-08-01 | @ TEX | 109 | L 3-10 | 45-64 | 4 | 24,143 | Billy Traber | John Thomson | John Thomson | Billy Traber | | 459 | 532 | -73 |
| 2003-08-02 | @ TEX | 110 | L 7-9 | 45-65 | 4 | 49,290 | Jason Davis | Joaquin Benoit | Erasmo Ramirez | Jason Stanford | Francisco Cordero | 466 | 541 | -75 |
| 2003-08-03 | @ TEX | 111 | L 5-8 | 45-66 | 4 | 19,133 | Brian Anderson | R.A. Dickey | R.A. Dickey | Brian Anderson | Francisco Cordero | 471 | 549 | -78 |
| 2003-08-05 | vs SEA | 112 | L 1-2 | 45-67 | 4 | 22,300 | CC Sabathia | Jamie Moyer | Jamie Moyer | CC Sabathia | Shigetoshi Hasegawa | 472 | 551 | -79 |
| 2003-08-06 | vs SEA | 113 | W 10-6 | 46-67 | 4 | 23,282 | Jake Westbrook | Joel Pineiro | Jake Westbrook | Joel Pineiro | | 482 | 557 | -75 |
| 2003-08-07 | vs SEA | 114 | W 3-0 | 47-67 | 4 | 21,141 | Billy Traber | Freddy Garcia | Billy Traber | Freddy Garcia | Danys Baez | 485 | 557 | -72 |
| 2003-08-08 | vs ANA | 115 | L 2-5 | 47-68 | 4 | 26,175 | Jason Davis | Jarrod Washburn | Jarrod Washburn | Jason Davis | | 487 | 562 | -75 |
| 2003-08-09 | vs ANA | 116 | W 3-2 | 49-68 | 4 | 26,391 | Brian Anderson | Kevin Gregg | Jack Cressend | Ben Weber | | 490 | 564 | -74 |
| 2003-08-09 | vs ANA | 117 | W 3-2 | 49-68 | 4 | 20,116 | Jason Stanford | Scot Shields | Jason Boyd | Scot Shields | Danys Baez | 493 | 566 | -73 |
| 2003-08-10 | vs ANA | 118 | W 3-1 | 50-68 | 4 | 23,576 | CC Sabathia | John Lackey | CC Sabathia | John Lackey | Rafael Betancourt | 496 | 567 | -71 |
| 2003-08-11 | @ MIN | 119 | L 3-5 | 50-69 | 4 | 23,291 | Jake Westbrook | Kyle Lohse | Kyle Lohse | Jake Westbrook | LaTroy Hawkins | 499 | 572 | -73 |
| 2003-08-12 | @ MIN | 120 | W 9-6 | 51-69 | 4 | 25,834 | Billy Traber | Joe Mays | Rafael Betancourt | James Baldwin | | 508 | 578 | -70 |
| 2003-08-13 | @ MIN | 121 | W 5-0 | 52-69 | 4 | 30,082 | Jason Davis | Johan Santana | Terry Mulholland | Juan Rincon | | 513 | 578 | -65 |
| 2003-08-14 | @ MIN | 122 | W 8-3 | 53-69 | 4 | 24,273 | Brian Anderson | Brad Radke | Brian Anderson | Brad Radke | | 521 | 581 | -60 |
| 2003-08-15 | vs TBA | 123 | W 1-0 | 54-69 | 4 | 19,679 | CC Sabathia | Victor Zambrano | CC Sabathia | Travis Harper | | 522 | 581 | -59 |
| 2003-08-16 | vs TBA | 124 | L 3-5 | 54-70 | 4 | 23,397 | Cliff Lee | Chad Gaudin | Mark Malaska | Cliff Lee | Lance Carter | 525 | 586 | -61 |
| 2003-08-17 | vs TBA | 125 | W 5-4 | 55-70 | 4 | 21,097 | Jake Westbrook | Joe Kennedy | Terry Mulholland | Jesus Colome | | 530 | 590 | -60 |
| 2003-08-18 | vs TBA | 126 | L 4-7 | 55-71 | 4 | 18,685 | Billy Traber | Rob Bell | Lance Carter | Terry Mulholland | | 534 | 597 | -63 |
| 2003-08-19 | vs MIN | 127 | L 2-8 | 55-72 | 4 | 21,239 | Jason Davis | Johan Santana | Johan Santana | Jason Davis | | 536 | 605 | -69 |
| 2003-08-20 | vs MIN | 128 | L 3-4 | 55-73 | 4 | 20,197 | Brian Anderson | Brad Radke | Brad Radke | Brian Anderson | Eddie Guardado | 539 | 609 | -70 |
| 2003-08-22 | @ TBA | 129 | W 8-3 | 56-73 | 4 | 11,979 | Cliff Lee | Joe Kennedy | Cliff Lee | Joe Kennedy | | 547 | 612 | -65 |
| 2003-08-23 | @ TBA | 130 | W 7-5 | 57-73 | 4 | 18,805 | CC Sabathia | Rob Bell | CC Sabathia | Brandon Backe | David Riske | 554 | 617 | -63 |
| 2003-08-24 | @ TBA | 131 | W 7-5 | 58-73 | 4 | 14,507 | Jake Westbrook | Geremi Gonzalez | Jake Westbrook | Geremi Gonzalez | David Riske | 561 | 622 | -61 |
| 2003-08-26 | vs DET | 132 | L 4-5 | 58-74 | 4 | 16,972 | Billy Traber | Nate Cornejo | Nate Cornejo | Billy Traber | Jamie Walker | 565 | 627 | -62 |
| 2003-08-27 | vs DET | 133 | W 9-7 | 59-74 | 4 | 16,457 | Terry Mulholland | Shane Loux | Jack Cressend | Chris Spurling | David Riske | 574 | 634 | -60 |
| 2003-08-28 | vs DET | 134 | W 8-3 | 60-74 | 4 | 16,282 | Cliff Lee | Jeremy Bonderman | Cliff Lee | Jeremy Bonderman | | 582 | 637 | -55 |
| 2003-08-29 | vs TOR | 135 | L 3-7 | 60-75 | 4 | 21,008 | CC Sabathia | Kelvim Escobar | Kelvim Escobar | CC Sabathia | | 585 | 644 | -59 |
| 2003-08-30 | vs TOR | 136 | L 3-9 | 60-76 | 4 | 21,806 | Jake Westbrook | Cory Lidle | Cory Lidle | Jake Westbrook | Josh Towers | 588 | 653 | -65 |
| 2003-08-31 | vs TOR | 137 | W 5-4 | 61-76 | 4 | 20,866 | Billy Traber | Mark Hendrickson | Danys Baez | Jason Kershner | | 593 | 657 | -64 |
| 2003-09-01 | @ DET | 138 | W 7-4 | 62-76 | 4 | 10,986 | Jason Stanford | Chris Mears | Jose Santiago | Jamie Walker | David Riske | 600 | 661 | -61 |
| 2003-09-02 | @ DET | 139 | L 6-8 | 62-77 | 4 | 9,318 | Cliff Lee | Jeremy Bonderman | Brian Schmack | Chad Durbin | Fernando Rodney | 606 | 669 | -63 |
| 2003-09-03 | @ DET | 140 | L 5-6 | 62-78 | 4 | 10,234 | CC Sabathia | Nate Robertson | Jamie Walker | Jose Santiago | | 611 | 675 | -64 |
| 2003-09-04 | @ DET | 141 | L 1-2 | 62-79 | 4 | 11,371 | Jake Westbrook | Gary Knotts | Gary Knotts | Jake Westbrook | Danny Patterson | 612 | 677 | -65 |
| 2003-09-05 | @ CHA | 142 | L 3-5 | 62-80 | 4 | 27,196 | Billy Traber | Jon Garland | Jon Garland | Billy Traber | Tom Gordon | 615 | 682 | -67 |
| 2003-09-06 | @ CHA | 143 | L 5-8 | 62-81 | 4 | 24,796 | Jason Stanford | Esteban Loaiza | Esteban Loaiza | Jack Cressend | Tom Gordon | 620 | 690 | -70 |
| 2003-09-07 | @ CHA | 144 | L 3-7 | 62-82 | 4 | 19,999 | Cliff Lee | Dan Wright | Scott Schoeneweis | Danys Baez | | 623 | 697 | -74 |
| 2003-09-09 | @ KCA | 145 | W 7-1 | 63-82 | 4 | 12,389 | Jason Davis | Jimmy Gobble | Jason Davis | Jimmy Gobble | | 630 | 698 | -68 |
| 2003-09-10 | @ KCA | 146 | L 7-9 | 63-83 | 4 | 21,581 | Chad Durbin | Brian Anderson | Kris Wilson | Jose Santiago | Jeremy Affeldt | 637 | 707 | -70 |
| 2003-09-11 | @ KCA | 147 | W 6-5 | 64-83 | 4 | 13,188 | Jake Westbrook | Darrell May | Danys Baez | Jason Grimsley | David Riske | 643 | 712 | -69 |
| 2003-09-12 | vs MIN | 148 | W 4-3 | 65-83 | 4 | 20,679 | CC Sabathia | Kenny Rogers | CC Sabathia | Kenny Rogers | David Riske | 647 | 715 | -68 |
| 2003-09-13 | vs MIN | 149 | L 0-2 | 65-84 | 4 | 20,440 | Jason Stanford | Kyle Lohse | Kyle Lohse | Jason Stanford | Eddie Guardado | 647 | 717 | -70 |
| 2003-09-14 | vs MIN | 150 | L 3-5 | 65-85 | 4 | 19,452 | Cliff Lee | Eric Milton | Juan Rincon | Danys Baez | Eddie Guardado | 650 | 722 | -72 |
| 2003-09-15 | vs MIN | 151 | L 6-13 | 65-86 | 4 | 16,967 | Jason Davis | Johan Santana | Johan Santana | Jason Davis | | 656 | 735 | -79 |
| 2003-09-16 | vs KCA | 152 | L 8-12 | 65-87 | 4 | 16,145 | Billy Traber | Darrell May | Darrell May | Billy Traber | | 664 | 747 | -83 |
| 2003-09-17 | vs KCA | 153 | W 9-1 | 66-87 | 4 | 16,363 | Jake Westbrook | Paul Abbott | Jake Westbrook | Paul Abbott | | 673 | 748 | -75 |
| 2003-09-18 | vs KCA | 154 | L 2-3 | 66-88 | 4 | 17,275 | CC Sabathia | Jose Lima | Jose Lima | CC Sabathia | Curt Leskanic | 675 | 751 | -76 |
| 2003-09-19 | vs BOS | 155 | L 0-2 | 66-89 | 4 | 20,374 | Jason Stanford | John Burkett | John Burkett | Jason Stanford | Alan Embree | 675 | 753 | -78 |
| 2003-09-20 | vs BOS | 156 | W 13-4 | 67-89 | 4 | 23,242 | Terry Mulholland | Derek Lowe | David Lee | Derek Lowe | | 688 | 757 | -69 |
| 2003-09-21 | vs BOS | 157 | L 0-2 | 67-90 | 4 | 27,655 | Cliff Lee | Pedro Martinez | Pedro Martinez | Cliff Lee | Byung-Hyun Kim | 688 | 759 | -71 |
| 2003-09-23 | @ MIN | 158 | L 1-4 | 67-91 | 4 | 33,650 | Jake Westbrook | Kenny Rogers | Kenny Rogers | Jake Westbrook | Eddie Guardado | 689 | 763 | -74 |
| 2003-09-24 | @ MIN | 159 | L 2-3 | 67-92 | 4 | 32,986 | CC Sabathia | Kyle Lohse | Jesse Orosco | Rafael Betancourt | Eddie Guardado | 691 | 766 | -75 |
| 2003-09-26 | @ TOR | 160 | W 2-1 | 68-92 | 4 | 13,861 | Jason Stanford | Cory Lidle | Jason Stanford | Cory Lidle | David Riske | 693 | 767 | -74 |
| 2003-09-27 | @ TOR | 161 | L 4-5 | 68-93 | 4 | 21,504 | Terry Mulholland | Roy Halladay | Roy Halladay | Terry Mulholland | | 697 | 772 | -75 |
| 2003-09-28 | @ TOR | 162 | L 2-6 | 68-94 | 4 | 22,014 | Cliff Lee | Josh Towers | Josh Towers | Cliff Lee | | 699 | 778 | -79 |