| 2003-03-31 | @ KCA | 1 | L 0-3 | 0-1 | 3 | 40,302 | Mark Buehrle | Runelvys Hernandez | Runelvys Hernandez | Mark Buehrle | Mike MacDougal | 0 | 3 | -3 |
| 2003-04-02 | @ KCA | 2 | L 4-5 | 0-2 | 4 | 10,429 | Bartolo Colon | Jeremy Affeldt | Albie Lopez | Rick White | Mike MacDougal | 4 | 8 | -4 |
| 2003-04-03 | @ KCA | 3 | L 6-12 | 0-3 | 4 | 9,524 | Jon Garland | Miguel Asencio | Ryan Bukvich | Tom Gordon | | 10 | 20 | -10 |
| 2003-04-04 | vs DET | 4 | W 5-2 | 1-3 | 4 | 40,395 | Esteban Loaiza | Nate Cornejo | Esteban Loaiza | Nate Cornejo | Billy Koch | 15 | 22 | -7 |
| 2003-04-05 | vs DET | 5 | W 7-0 | 2-3 | 3 | 16,972 | Mark Buehrle | Mike Maroth | Mark Buehrle | Mike Maroth | | 22 | 22 | 0 |
| 2003-04-06 | vs DET | 6 | W 10-2 | 3-3 | 2 | 14,514 | Josh Stewart | Gary Knotts | Damaso Marte | Franklyn German | | 32 | 24 | 8 |
| 2003-04-08 | @ CLE | 7 | W 5-3 | 4-3 | 2 | 42,301 | Bartolo Colon | Ricardo Rodriguez | Billy Koch | Chad Paronto | | 37 | 27 | 10 |
| 2003-04-09 | @ CLE | 8 | L 2-5 | 4-4 | 2 | 14,841 | Jon Garland | Brian Anderson | Brian Anderson | Jon Garland | Danys Baez | 39 | 32 | 7 |
| 2003-04-10 | @ CLE | 9 | W 7-2 | 5-4 | 2 | 15,916 | Mark Buehrle | Jason Davis | Mark Buehrle | Jason Davis | | 46 | 34 | 12 |
| 2003-04-11 | @ DET | 10 | W 5-0 | 6-4 | 2 | 12,577 | Esteban Loaiza | Adam Bernero | Esteban Loaiza | Adam Bernero | | 51 | 34 | 17 |
| 2003-04-12 | @ DET | 11 | L 3-4 | 6-5 | 2 | 12,985 | Josh Stewart | Nate Cornejo | Nate Cornejo | Josh Stewart | Matt Anderson | 54 | 38 | 16 |
| 2003-04-13 | @ DET | 12 | W 3-2 | 7-5 | 2 | 12,808 | Bartolo Colon | Gary Knotts | Bartolo Colon | Gary Knotts | Billy Koch | 57 | 40 | 17 |
| 2003-04-15 | vs KCA | 13 | L 5-8 | 7-6 | 2 | 20,591 | Mark Buehrle | Miguel Asencio | Albie Lopez | Billy Koch | Mike MacDougal | 62 | 48 | 14 |
| 2003-04-16 | vs KCA | 14 | W 4-3 | 8-6 | 2 | 9,882 | Jon Garland | Runelvys Hernandez | Tom Gordon | Jason Grimsley | | 66 | 51 | 15 |
| 2003-04-17 | vs KCA | 15 | W 8-2 | 9-6 | 2 | 10,716 | Esteban Loaiza | Chris George | Esteban Loaiza | Chris George | | 74 | 53 | 21 |
| 2003-04-18 | vs CLE | 16 | W 5-3 | 10-6 | 2 | 13,015 | Bartolo Colon | Ricardo Rodriguez | Bartolo Colon | Billy Traber | | 79 | 56 | 23 |
| 2003-04-19 | vs CLE | 17 | W 12-3 | 11-6 | 2 | 18,907 | Josh Stewart | Brian Anderson | Josh Stewart | Brian Anderson | | 91 | 59 | 32 |
| 2003-04-20 | vs CLE | 18 | L 4-7 | 11-7 | 2 | 14,975 | Mark Buehrle | Jason Davis | Jason Davis | Mark Buehrle | | 95 | 66 | 29 |
| 2003-04-21 | vs CLE | 19 | L 2-9 | 11-8 | 2 | 15,424 | Jon Garland | Jake Westbrook | Jake Westbrook | Jon Garland | | 97 | 75 | 22 |
| 2003-04-22 | @ BAL | 20 | W 3-1 | 12-8 | 2 | 18,676 | Esteban Loaiza | Sidney Ponson | Esteban Loaiza | Sidney Ponson | Billy Koch | 100 | 76 | 24 |
| 2003-04-23 | @ BAL | 21 | L 1-7 | 12-9 | 2 | 19,908 | Bartolo Colon | Jason Johnson | Jason Johnson | Bartolo Colon | | 101 | 83 | 18 |
| 2003-04-24 | @ BAL | 22 | L 4-5 | 12-10 | 2 | 23,731 | Josh Stewart | Rodrigo Lopez | Willis Roberts | Tom Gordon | Jorge Julio | 105 | 88 | 17 |
| 2003-04-25 | vs MIN | 23 | L 1-6 | 12-11 | 2 | 14,285 | Mark Buehrle | Joe Mays | Joe Mays | Mark Buehrle | | 106 | 94 | 12 |
| 2003-04-26 | vs MIN | 24 | W 7-4 | 13-11 | 2 | 25,381 | Jon Garland | Kyle Lohse | Jon Garland | Kyle Lohse | | 113 | 98 | 15 |
| 2003-04-27 | vs MIN | 25 | W 3-1 | 14-11 | 2 | 22,714 | Esteban Loaiza | Rick Reed | Esteban Loaiza | Rick Reed | Damaso Marte | 116 | 99 | 17 |
| 2003-04-29 | vs OAK | 26 | L 2-3 | 14-12 | 2 | 13,936 | Bartolo Colon | Barry Zito | Barry Zito | Bartolo Colon | Keith Foulke | 118 | 102 | 16 |
| 2003-04-30 | vs OAK | 27 | L 1-4 | 14-13 | 2 | 11,084 | Mark Buehrle | Mark Mulder | Mark Mulder | Mark Buehrle | | 119 | 106 | 13 |
| 2003-05-01 | vs OAK | 28 | W 7-5 | 15-13 | 2 | 10,639 | Jon Garland | John Halama | Jon Garland | John Halama | Damaso Marte | 126 | 111 | 15 |
| 2003-05-02 | vs SEA | 29 | L 2-9 | 15-14 | 2 | 13,355 | Esteban Loaiza | Ryan Franklin | Ryan Franklin | Esteban Loaiza | | 128 | 120 | 8 |
| 2003-05-03 | vs SEA | 30 | L 2-12 | 15-15 | 2 | 25,837 | Josh Stewart | Freddy Garcia | Freddy Garcia | Josh Stewart | | 130 | 132 | -2 |
| 2003-05-04 | vs SEA | 31 | L 1-5 | 15-16 | 3 | 15,413 | Bartolo Colon | Gil Meche | Gil Meche | Bartolo Colon | | 131 | 137 | -6 |
| 2003-05-06 | @ OAK | 32 | L 0-6 | 15-17 | 3 | 10,695 | Mark Buehrle | Mark Mulder | Mark Mulder | Mark Buehrle | | 131 | 143 | -12 |
| 2003-05-07 | @ OAK | 33 | W 8-4 | 16-17 | 3 | 20,715 | Esteban Loaiza | Ted Lilly | Esteban Loaiza | Ted Lilly | Damaso Marte | 139 | 147 | -8 |
| 2003-05-08 | @ OAK | 34 | L 5-8 | 16-18 | 3 | 12,329 | Jon Garland | John Halama | John Halama | Jon Garland | Keith Foulke | 144 | 155 | -11 |
| 2003-05-09 | @ SEA | 35 | L 3-6 | 16-19 | 3 | 38,749 | Dan Wright | Ryan Franklin | Ryan Franklin | Dan Wright | Jeff Nelson | 147 | 161 | -14 |
| 2003-05-10 | @ SEA | 36 | W 4-3 | 17-19 | 3 | 43,123 | Bartolo Colon | Gil Meche | Bartolo Colon | Gil Meche | Damaso Marte | 151 | 164 | -13 |
| 2003-05-11 | @ SEA | 37 | L 2-7 | 17-20 | 3 | 45,383 | Mark Buehrle | Jamie Moyer | Jamie Moyer | Mark Buehrle | | 153 | 171 | -18 |
| 2003-05-13 | vs BAL | 38 | W 1-0 | 18-20 | 3 | 14,397 | Esteban Loaiza | Omar Daal | Esteban Loaiza | Omar Daal | Billy Koch | 154 | 171 | -17 |
| 2003-05-14 | vs BAL | 39 | W 5-1 | 19-20 | 3 | 12,078 | Dan Wright | Rick Helling | Tom Gordon | Rick Helling | | 159 | 172 | -13 |
| 2003-05-15 | vs BAL | 40 | W 8-2 | 20-20 | 3 | 11,886 | Bartolo Colon | Sidney Ponson | Bartolo Colon | Sidney Ponson | | 167 | 174 | -7 |
| 2003-05-16 | @ MIN | 41 | L 3-18 | 20-21 | 3 | 22,233 | Mark Buehrle | Brad Radke | Brad Radke | Mark Buehrle | | 170 | 192 | -22 |
| 2003-05-17 | @ MIN | 42 | L 1-3 | 20-22 | 3 | 23,209 | Jon Garland | Joe Mays | Joe Mays | Jon Garland | Eddie Guardado | 171 | 195 | -24 |
| 2003-05-18 | @ MIN | 43 | L 2-3 | 20-23 | 3 | 25,055 | Esteban Loaiza | Kyle Lohse | LaTroy Hawkins | Tom Gordon | Eddie Guardado | 173 | 198 | -25 |
| 2003-05-19 | vs TOR | 44 | L 2-12 | 20-24 | 3 | 19,628 | Dan Wright | Cory Lidle | Cory Lidle | Dan Wright | | 175 | 210 | -35 |
| 2003-05-20 | vs TOR | 45 | W 4-1 | 21-24 | 3 | 12,857 | Bartolo Colon | Doug Davis | Bartolo Colon | Doug Davis | | 179 | 211 | -32 |
| 2003-05-21 | vs TOR | 46 | W 6-5 | 22-24 | 3 | 13,076 | Mark Buehrle | Mark Hendrickson | Damaso Marte | Cliff Politte | Billy Koch | 185 | 216 | -31 |
| 2003-05-23 | vs DET | 47 | L 2-3 | 22-25 | 3 | 15,069 | Jon Garland | Mike Maroth | Mike Maroth | Tom Gordon | Chris Spurling | 187 | 219 | -32 |
| 2003-05-24 | vs DET | 48 | L 0-1 | 22-26 | 3 | 27,535 | Esteban Loaiza | Gary Knotts | Gary Knotts | Esteban Loaiza | Franklyn German | 187 | 220 | -33 |
| 2003-05-25 | vs DET | 49 | W 8-5 | 23-26 | 3 | 21,398 | Dan Wright | Adam Bernero | Gary Glover | Steve Sparks | | 195 | 225 | -30 |
| 2003-05-26 | @ TOR | 50 | L 5-11 | 23-27 | 3 | 19,009 | Mark Buehrle | Mark Hendrickson | Josh Towers | Mark Buehrle | Jeff Tam | 200 | 236 | -36 |
| 2003-05-27 | @ TOR | 51 | L 1-5 | 23-28 | 3 | 19,365 | Bartolo Colon | Roy Halladay | Roy Halladay | Bartolo Colon | | 201 | 241 | -40 |
| 2003-05-28 | @ TOR | 52 | W 8-0 | 24-28 | 3 | 36,806 | Jon Garland | Kelvim Escobar | Jon Garland | Kelvim Escobar | | 209 | 241 | -32 |
| 2003-05-29 | @ TOR | 53 | W 3-2 | 25-28 | 3 | 20,010 | Esteban Loaiza | Cory Lidle | Esteban Loaiza | Cory Lidle | Billy Koch | 212 | 243 | -31 |
| 2003-05-30 | @ CLE | 54 | L 3-7 | 25-29 | 3 | 24,666 | Dan Wright | CC Sabathia | CC Sabathia | Dan Wright | | 215 | 250 | -35 |
| 2003-06-01 | @ CLE | 55 | L 4-5 | 25-30 | 3 | 22,681 | Mark Buehrle | Jason Davis | Jason Boyd | Billy Koch | | 219 | 255 | -36 |
| 2003-06-02 | @ CLE | 56 | L 2-5 | 25-31 | 3 | 20,892 | Bartolo Colon | Brian Anderson | Brian Anderson | Bartolo Colon | Danys Baez | 221 | 260 | -39 |
| 2003-06-03 | @ ARI | 57 | L 1-2 | 25-32 | 3 | 33,544 | Esteban Loaiza | Miguel Batista | Oscar Villarreal | Tom Gordon | | 222 | 262 | -40 |
| 2003-06-04 | @ ARI | 58 | L 6-8 | 25-33 | 3 | 26,667 | Jon Garland | Andrew Good | Andrew Good | Jon Garland | Jose Valverde | 228 | 270 | -42 |
| 2003-06-05 | @ ARI | 59 | W 3-2 | 26-33 | 3 | 27,747 | Dan Wright | Elmer Dessens | Billy Koch | Scott Service | | 231 | 272 | -41 |
| 2003-06-06 | @ LAN | 60 | L 1-2 | 26-34 | 3 | 35,503 | Mark Buehrle | Kazuhisa Ishii | Kazuhisa Ishii | Mark Buehrle | Eric Gagne | 232 | 274 | -42 |
| 2003-06-07 | @ LAN | 61 | W 4-1 | 27-34 | 3 | 44,122 | Bartolo Colon | Andy Ashby | Bartolo Colon | Andy Ashby | | 236 | 275 | -39 |
| 2003-06-08 | @ LAN | 62 | W 10-3 | 28-34 | 3 | 52,637 | Esteban Loaiza | Odalis Perez | Esteban Loaiza | Odalis Perez | | 246 | 278 | -32 |
| 2003-06-10 | vs SFN | 63 | W 5-3 | 29-34 | 3 | 23,837 | Jon Garland | Jerome Williams | Jon Garland | Joe Nathan | | 251 | 281 | -30 |
| 2003-06-11 | vs SFN | 64 | L 4-11 | 29-35 | 3 | 19,114 | Mark Buehrle | Jesse Foppert | Jesse Foppert | Mark Buehrle | | 255 | 292 | -37 |
| 2003-06-12 | vs SFN | 65 | L 4-8 | 29-36 | 3 | 22,827 | Bartolo Colon | Kirk Rueter | Joe Nathan | Bartolo Colon | | 259 | 300 | -41 |
| 2003-06-13 | vs SDN | 66 | W 5-3 | 30-36 | 3 | 14,162 | Esteban Loaiza | Kevin Jarvis | Tom Gordon | Scott Linebrink | Billy Koch | 264 | 303 | -39 |
| 2003-06-14 | vs SDN | 67 | W 6-5 | 31-36 | 3 | 27,287 | Dan Wright | Brian Lawrence | Tom Gordon | Jay Witasick | Billy Koch | 270 | 308 | -38 |
| 2003-06-15 | vs SDN | 68 | L 0-1 | 31-37 | 3 | 26,491 | Jon Garland | Oliver Perez | Oliver Perez | Jon Garland | Rod Beck | 270 | 309 | -39 |
| 2003-06-16 | vs BOS | 69 | W 4-2 | 32-37 | 3 | 30,779 | Mark Buehrle | Pedro Martinez | Mark Buehrle | Ryan Rupe | Tom Gordon | 274 | 311 | -37 |
| 2003-06-17 | vs BOS | 70 | L 4-7 | 32-38 | 3 | 19,887 | Bartolo Colon | John Burkett | John Burkett | Bartolo Colon | Brandon Lyon | 278 | 318 | -40 |
| 2003-06-18 | vs BOS | 71 | W 3-1 | 33-38 | 3 | 18,708 | Esteban Loaiza | Tim Wakefield | Esteban Loaiza | Tim Wakefield | Billy Koch | 281 | 319 | -38 |
| 2003-06-19 | vs BOS | 72 | L 3-4 | 33-39 | 3 | 17,225 | Dan Wright | Derek Lowe | Brandon Lyon | Billy Koch | | 284 | 323 | -39 |
| 2003-06-20 | @ CHN | 73 | W 12-3 | 34-39 | 3 | 39,080 | Jon Garland | Shawn Estes | Jon Garland | Shawn Estes | | 296 | 326 | -30 |
| 2003-06-21 | @ CHN | 74 | W 7-6 | 35-39 | 3 | 38,938 | Mark Buehrle | Matt Clement | Mark Buehrle | Matt Clement | Billy Koch | 303 | 332 | -29 |
| 2003-06-22 | @ CHN | 75 | L 1-2 | 35-40 | 3 | 38,223 | Bartolo Colon | Carlos Zambrano | Carlos Zambrano | Damaso Marte | Joe Borowski | 304 | 334 | -30 |
| 2003-06-24 | @ MIN | 76 | W 2-1 | 36-40 | 3 | 19,229 | Esteban Loaiza | Rick Reed | Esteban Loaiza | Rick Reed | Billy Koch | 306 | 335 | -29 |
| 2003-06-25 | @ MIN | 77 | L 5-6 | 36-41 | 3 | 21,338 | Jon Garland | Joe Mays | Eddie Guardado | Billy Koch | | 311 | 341 | -30 |
| 2003-06-26 | @ MIN | 78 | W 5-1 | 37-41 | 3 | 26,474 | Mark Buehrle | Brad Radke | Mark Buehrle | Brad Radke | | 316 | 342 | -26 |
| 2003-06-27 | vs CHN | 79 | W 4-3 | 38-41 | 3 | 45,147 | Dan Wright | Matt Clement | Billy Koch | Antonio Alfonseca | | 320 | 345 | -25 |
| 2003-06-28 | vs CHN | 80 | W 7-6 | 39-41 | 3 | 45,440 | Bartolo Colon | Carlos Zambrano | Billy Koch | Juan Cruz | | 327 | 351 | -24 |
| 2003-06-29 | vs CHN | 81 | L 2-5 | 39-42 | 3 | 44,858 | Esteban Loaiza | Kerry Wood | Kerry Wood | Esteban Loaiza | | 329 | 356 | -27 |
| 2003-06-30 | vs MIN | 82 | W 10-3 | 40-42 | 3 | 29,945 | Jon Garland | Joe Mays | Jon Garland | Joe Mays | | 339 | 359 | -20 |
| 2003-07-01 | vs MIN | 83 | W 6-1 | 41-42 | 3 | 30,694 | Mark Buehrle | Brad Radke | Mark Buehrle | Brad Radke | | 345 | 360 | -15 |
| 2003-07-02 | vs MIN | 84 | W 8-6 | 42-42 | 3 | 19,555 | Dan Wright | Kyle Lohse | Billy Koch | Eddie Guardado | | 353 | 366 | -13 |
| 2003-07-04 | @ TBA | 85 | L 3-4 | 42-43 | 3 | 9,493 | Bartolo Colon | Victor Zambrano | Jesus Colome | Billy Koch | | 356 | 370 | -14 |
| 2003-07-05 | @ TBA | 86 | L 2-3 | 42-44 | 3 | 13,365 | Esteban Loaiza | Jorge Sosa | Jorge Sosa | Esteban Loaiza | Lance Carter | 358 | 373 | -15 |
| 2003-07-06 | @ TBA | 87 | W 11-3 | 43-44 | 3 | 11,683 | Mark Buehrle | Jason Standridge | Mark Buehrle | Jason Standridge | | 369 | 376 | -7 |
| 2003-07-08 | @ DET | 88 | L 1-2 | 43-45 | 3 | 13,643 | Jon Garland | Wil Ledezma | Chris Spurling | Jon Garland | Chris Mears | 370 | 378 | -8 |
| 2003-07-09 | @ DET | 89 | L 2-4 | 43-46 | 3 | 12,869 | Bartolo Colon | Jeremy Bonderman | Jeremy Bonderman | Bartolo Colon | Chris Mears | 372 | 382 | -10 |
| 2003-07-10 | @ DET | 90 | L 0-1 | 43-47 | 3 | 18,206 | Esteban Loaiza | Nate Cornejo | Nate Cornejo | Esteban Loaiza | Chris Mears | 372 | 383 | -11 |
| 2003-07-11 | @ CLE | 91 | L 5-12 | 43-48 | 3 | 27,712 | Dan Wright | Brian Anderson | Brian Anderson | Dan Wright | | 377 | 395 | -18 |
| 2003-07-12 | @ CLE | 92 | W 7-4 | 44-49 | 3 | 24,163 | Mark Buehrle | Jason Stanford | Damaso Marte | Terry Mulholland | Tom Gordon | 384 | 399 | -15 |
| 2003-07-12 | @ CLE | 93 | L 2-4 | 44-49 | 3 | 27,165 | Mike Porzio | Jake Westbrook | Jake Westbrook | Mike Porzio | Danys Baez | 386 | 403 | -17 |
| 2003-07-13 | @ CLE | 94 | W 7-4 | 45-49 | 2 | 26,467 | Jon Garland | Billy Traber | Damaso Marte | Rafael Betancourt | Tom Gordon | 393 | 407 | -14 |
| 2003-07-17 | vs DET | 95 | L 9-10 | 45-50 | 3 | 17,060 | Bartolo Colon | Mike Maroth | Mike Maroth | Bartolo Colon | | 402 | 417 | -15 |
| 2003-07-18 | vs DET | 96 | W 7-5 | 46-50 | 3 | 18,868 | Mark Buehrle | Matt Roney | Mark Buehrle | Matt Roney | Tom Gordon | 409 | 422 | -13 |
| 2003-07-19 | vs DET | 97 | W 6-2 | 47-50 | 3 | 32,245 | Jon Garland | Nate Cornejo | Jon Garland | Nate Cornejo | Damaso Marte | 415 | 424 | -9 |
| 2003-07-20 | vs DET | 98 | W 10-1 | 48-50 | 3 | 20,631 | Esteban Loaiza | Wil Ledezma | Esteban Loaiza | Wil Ledezma | | 425 | 425 | 0 |
| 2003-07-21 | vs CLE | 99 | W 4-3 | 49-50 | 3 | 31,776 | Mike Porzio | Brian Tallet | Mike Porzio | Brian Tallet | Tom Gordon | 429 | 428 | 1 |
| 2003-07-22 | vs CLE | 100 | W 5-2 | 50-50 | 2 | 20,667 | Bartolo Colon | Jason Davis | Bartolo Colon | Jason Davis | Damaso Marte | 434 | 430 | 4 |
| 2003-07-23 | @ TOR | 101 | W 7-6 | 51-50 | 2 | 20,320 | Mark Buehrle | Roy Halladay | Rick White | Juan Acevedo | Damaso Marte | 441 | 436 | 5 |
| 2003-07-24 | @ TOR | 102 | W 4-3 | 52-50 | 2 | 18,438 | Jon Garland | Kelvim Escobar | Tom Gordon | Tanyon Sturtze | Rick White | 445 | 439 | 6 |
| 2003-07-25 | vs TBA | 103 | W 7-2 | 53-50 | 2 | 22,617 | Esteban Loaiza | Jorge Sosa | Esteban Loaiza | Jorge Sosa | | 452 | 441 | 11 |
| 2003-07-26 | vs TBA | 104 | L 6-10 | 53-51 | 2 | 29,633 | Mike Porzio | Rob Bell | Mark Malaska | Rick White | Jesus Colome | 458 | 451 | 7 |
| 2003-07-27 | vs TBA | 105 | W 9-1 | 54-51 | 2 | 28,027 | Bartolo Colon | Joe Kennedy | Bartolo Colon | Joe Kennedy | | 467 | 452 | 15 |
| 2003-07-29 | @ KCA | 106 | W 9-6 | 55-51 | 2 | 24,485 | Mark Buehrle | Darrell May | Mark Buehrle | Darrell May | Tom Gordon | 476 | 458 | 18 |
| 2003-07-30 | @ KCA | 107 | W 15-4 | 56-51 | 2 | 20,722 | Jon Garland | Runelvys Hernandez | Jon Garland | Runelvys Hernandez | | 491 | 462 | 29 |
| 2003-07-31 | @ KCA | 108 | W 8-6 | 57-51 | 2 | 21,352 | Esteban Loaiza | Kyle Snyder | Scott Schoeneweis | Nate Field | | 499 | 468 | 31 |
| 2003-08-01 | @ SEA | 109 | W 12-1 | 58-51 | 2 | 39,337 | Bartolo Colon | Freddy Garcia | Bartolo Colon | Freddy Garcia | | 511 | 469 | 42 |
| 2003-08-02 | @ SEA | 110 | L 0-10 | 58-52 | 2 | 45,719 | Dan Wright | Ryan Franklin | Ryan Franklin | Dan Wright | | 511 | 479 | 32 |
| 2003-08-03 | @ SEA | 111 | L 2-8 | 58-53 | 2 | 45,632 | Mark Buehrle | Gil Meche | Gil Meche | Mark Buehrle | | 513 | 487 | 26 |
| 2003-08-04 | vs KCA | 112 | L 9-13 | 58-54 | 2 | 43,922 | Jon Garland | Runelvys Hernandez | Runelvys Hernandez | Scott Schoeneweis | Al Levine | 522 | 500 | 22 |
| 2003-08-05 | vs KCA | 113 | W 5-4 | 59-54 | 2 | 38,973 | Esteban Loaiza | Kyle Snyder | Esteban Loaiza | Kyle Snyder | Damaso Marte | 527 | 504 | 23 |
| 2003-08-06 | vs KCA | 114 | W 4-3 | 60-54 | 2 | 25,348 | Bartolo Colon | Kris Wilson | Bartolo Colon | Kris Wilson | Damaso Marte | 531 | 507 | 24 |
| 2003-08-08 | vs OAK | 115 | W 3-2 | 61-54 | 1 | 24,118 | Mark Buehrle | Mark Mulder | Mark Buehrle | Mark Mulder | | 534 | 509 | 25 |
| 2003-08-09 | vs OAK | 116 | L 2-7 | 61-55 | 2 | 36,151 | Jon Garland | Ted Lilly | Chad Bradford | Jon Garland | | 536 | 516 | 20 |
| 2003-08-10 | vs OAK | 117 | W 5-1 | 62-55 | 2 | 29,442 | Esteban Loaiza | Rich Harden | Esteban Loaiza | Rich Harden | | 541 | 517 | 24 |
| 2003-08-11 | @ ANA | 118 | L 8-10 | 62-56 | 2 | 35,889 | Bartolo Colon | Aaron Sele | Ben Weber | Bartolo Colon | | 549 | 527 | 22 |
| 2003-08-12 | @ ANA | 119 | W 10-4 | 63-56 | 2 | 36,458 | Neal Cotts | Ramon Ortiz | Dan Wright | Ramon Ortiz | | 559 | 531 | 28 |
| 2003-08-13 | @ ANA | 120 | L 1-2 | 63-57 | 2 | 37,563 | Mark Buehrle | Jarrod Washburn | Francisco Rodriguez | Mark Buehrle | Troy Percival | 560 | 533 | 27 |
| 2003-08-14 | @ ANA | 121 | L 1-5 | 63-58 | 2 | 35,056 | Jon Garland | Scot Shields | Scot Shields | Jon Garland | Troy Percival | 561 | 538 | 23 |
| 2003-08-15 | @ TEX | 122 | L 5-11 | 63-59 | 2 | 21,186 | Esteban Loaiza | Colby Lewis | Colby Lewis | Esteban Loaiza | | 566 | 549 | 17 |
| 2003-08-16 | @ TEX | 123 | L 8-12 | 63-60 | 2 | 40,072 | Bartolo Colon | Robert Ellis | Joaquin Benoit | Bartolo Colon | | 574 | 561 | 13 |
| 2003-08-17 | @ TEX | 124 | L 4-6 | 63-61 | 2 | 17,015 | Neal Cotts | Juan Dominguez | Jay Powell | Damaso Marte | Francisco Cordero | 578 | 567 | 11 |
| 2003-08-18 | vs ANA | 125 | W 4-2 | 64-61 | 2 | 32,381 | Mark Buehrle | Jarrod Washburn | Tom Gordon | Jarrod Washburn | | 582 | 569 | 13 |
| 2003-08-19 | vs ANA | 126 | W 5-2 | 65-61 | 2 | 22,396 | Jon Garland | Scot Shields | Jon Garland | Scot Shields | Tom Gordon | 587 | 571 | 16 |
| 2003-08-20 | vs ANA | 127 | W 5-3 | 66-61 | 2 | 17,879 | Esteban Loaiza | John Lackey | Esteban Loaiza | John Lackey | Damaso Marte | 592 | 574 | 18 |
| 2003-08-21 | vs TEX | 128 | W 7-3 | 67-61 | 1 | 18,305 | Bartolo Colon | Colby Lewis | Bartolo Colon | Colby Lewis | Tom Gordon | 599 | 577 | 22 |
| 2003-08-22 | vs TEX | 129 | W 7-1 | 68-61 | 1 | 36,311 | Neal Cotts | Juan Dominguez | Neal Cotts | Juan Dominguez | | 606 | 578 | 28 |
| 2003-08-23 | vs TEX | 130 | W 13-2 | 69-61 | 1 | 33,721 | Mark Buehrle | Ismael Valdez | Mark Buehrle | Ismael Valdez | Dan Wright | 619 | 580 | 39 |
| 2003-08-24 | vs TEX | 131 | L 0-5 | 69-62 | 1 | 29,364 | Jon Garland | John Thomson | John Thomson | Jon Garland | | 619 | 585 | 34 |
| 2003-08-26 | @ NYA | 132 | W 13-2 | 70-62 | 1 | 38,884 | Esteban Loaiza | Roger Clemens | Esteban Loaiza | Roger Clemens | | 632 | 587 | 45 |
| 2003-08-27 | @ NYA | 133 | W 11-2 | 71-62 | 1 | 40,654 | Bartolo Colon | David Wells | Bartolo Colon | David Wells | | 643 | 589 | 54 |
| 2003-08-28 | @ NYA | 134 | L 5-7 | 71-63 | 2 | 40,569 | Neal Cotts | Mike Mussina | Mike Mussina | Neal Cotts | Mariano Rivera | 648 | 596 | 52 |
| 2003-08-29 | @ DET | 135 | L 4-8 | 71-64 | 2 | 15,828 | Mark Buehrle | Nate Robertson | Nate Robertson | Mark Buehrle | | 652 | 604 | 48 |
| 2003-08-30 | @ DET | 136 | W 5-2 | 72-64 | 1 | 15,786 | Jon Garland | Mike Maroth | Jon Garland | Mike Maroth | | 657 | 606 | 51 |
| 2003-08-31 | @ DET | 137 | W 6-1 | 73-64 | 1 | 15,873 | Esteban Loaiza | Nate Cornejo | Esteban Loaiza | Nate Cornejo | | 663 | 607 | 56 |
| 2003-09-02 | vs BOS | 138 | L 1-2 | 73-65 | 1 | 23,943 | Bartolo Colon | John Burkett | John Burkett | Bartolo Colon | Byung-Hyun Kim | 664 | 609 | 55 |
| 2003-09-03 | vs BOS | 139 | L 4-5 | 73-66 | 1 | 20,082 | Mark Buehrle | Derek Lowe | Byung-Hyun Kim | Tom Gordon | | 668 | 614 | 54 |
| 2003-09-05 | vs CLE | 140 | W 5-3 | 74-66 | 1 | 27,196 | Jon Garland | Billy Traber | Jon Garland | Billy Traber | Tom Gordon | 673 | 617 | 56 |
| 2003-09-06 | vs CLE | 141 | W 8-5 | 75-66 | 1 | 24,796 | Esteban Loaiza | Jason Stanford | Esteban Loaiza | Jack Cressend | Tom Gordon | 681 | 622 | 59 |
| 2003-09-07 | vs CLE | 142 | W 7-3 | 76-66 | 1 | 19,999 | Dan Wright | Cliff Lee | Scott Schoeneweis | Danys Baez | | 688 | 625 | 63 |
| 2003-09-08 | vs MIN | 143 | W 5-2 | 77-66 | 1 | 32,807 | Bartolo Colon | Kyle Lohse | Bartolo Colon | Kyle Lohse | | 693 | 627 | 66 |
| 2003-09-09 | vs MIN | 144 | W 8-6 | 78-66 | 1 | 27,623 | Mark Buehrle | Carlos Pulido | Mark Buehrle | Carlos Pulido | Tom Gordon | 701 | 633 | 68 |
| 2003-09-10 | vs MIN | 145 | L 1-4 | 78-67 | 1 | 22,188 | Jon Garland | Johan Santana | Johan Santana | Jon Garland | Eddie Guardado | 702 | 637 | 65 |
| 2003-09-11 | vs MIN | 146 | L 2-5 | 78-68 | 1 | 20,541 | Esteban Loaiza | Brad Radke | Brad Radke | Esteban Loaiza | | 704 | 642 | 62 |
| 2003-09-12 | @ BOS | 147 | L 4-7 | 78-69 | 1 | 34,890 | Dan Wright | Jeff Suppan | Jeff Suppan | Dan Wright | Byung-Hyun Kim | 708 | 649 | 59 |
| 2003-09-13 | @ BOS | 148 | W 3-1 | 79-69 | 1 | 34,414 | Bartolo Colon | Tim Wakefield | Bartolo Colon | Tim Wakefield | | 711 | 650 | 61 |
| 2003-09-14 | @ BOS | 149 | W 7-2 | 80-69 | 1 | 34,174 | Mark Buehrle | John Burkett | Mark Buehrle | John Burkett | Damaso Marte | 718 | 652 | 66 |
| 2003-09-16 | @ MIN | 150 | L 2-5 | 80-70 | 2 | 32,921 | Esteban Loaiza | Brad Radke | Brad Radke | Esteban Loaiza | | 720 | 657 | 63 |
| 2003-09-17 | @ MIN | 151 | L 2-4 | 80-71 | 2 | 40,304 | Jon Garland | Kenny Rogers | Kenny Rogers | Jon Garland | Eddie Guardado | 722 | 661 | 61 |
| 2003-09-18 | @ MIN | 152 | L 3-5 | 80-72 | 2 | 39,948 | Bartolo Colon | Kyle Lohse | Kyle Lohse | Bartolo Colon | Eddie Guardado | 725 | 666 | 59 |
| 2003-09-19 | vs KCA | 153 | W 8-5 | 81-72 | 2 | 32,812 | Mark Buehrle | Jamey Wright | Mark Buehrle | D.J. Carrasco | Tom Gordon | 733 | 671 | 62 |
| 2003-09-20 | vs KCA | 154 | L 1-7 | 81-73 | 2 | 37,367 | Esteban Loaiza | Brian Anderson | Brian Anderson | Esteban Loaiza | | 734 | 678 | 56 |
| 2003-09-21 | vs KCA | 155 | L 4-10 | 81-74 | 2 | 31,539 | Jon Garland | Darrell May | Darrell May | Jon Garland | | 738 | 688 | 50 |
| 2003-09-22 | vs NYA | 156 | W 6-3 | 82-74 | 2 | 39,627 | Bartolo Colon | David Wells | Tom Gordon | Gabe White | | 744 | 691 | 53 |
| 2003-09-23 | vs NYA | 157 | L 0-7 | 82-75 | 2 | 31,305 | Mark Buehrle | Jose Contreras | Jose Contreras | Mark Buehrle | | 744 | 698 | 46 |
| 2003-09-24 | vs NYA | 158 | W 9-4 | 83-75 | 2 | 26,019 | Esteban Loaiza | Mike Mussina | Esteban Loaiza | Mike Mussina | | 753 | 702 | 51 |
| 2003-09-25 | @ KCA | 159 | L 3-7 | 83-76 | 2 | 16,438 | Dan Wright | Brian Anderson | Brian Anderson | Dan Wright | | 756 | 709 | 47 |
| 2003-09-26 | @ KCA | 160 | W 11-2 | 84-76 | 2 | 36,598 | Jon Garland | Darrell May | Jon Garland | Darrell May | | 767 | 711 | 56 |
| 2003-09-27 | @ KCA | 161 | W 19-3 | 85-76 | 2 | 37,567 | Bartolo Colon | Jamey Wright | Bartolo Colon | Jamey Wright | | 786 | 714 | 72 |
| 2003-09-28 | @ KCA | 162 | W 5-1 | 86-76 | 2 | 26,261 | Esteban Loaiza | Jose Lima | Esteban Loaiza | Jose Lima | | 791 | 715 | 76 |