| 25 | Abe Alvarez | P | MLB | 6-3 | 185 | Left | Left | 10/17/1982 | 20 | Los Angeles,California | 2003 | 2 | 49 | BOS |
|
| 46 | Wes Anderson | P | A+ | 6-4 | 175 | Right | Right | 9/10/1979 | 23 | Pine Bluff,Arkansas | 1997 | 14 | 426 | FLA |
| 26 | Claudio Arias | 3B | AA | 6-2 | 200 | Right | Right | 5/9/1982 | 21 | Bani,Dominican Republic | 2002 | UDFA | | BOS |
| 29 | Bryan Barnowski | 1B | A | 6-2 | 205 | Right | Right | 9/3/1980 | 22 | Hartford,Connecticut | 1998 | 42 | 1255 | BOS |
| 39 | Zach Basch | P | A- | 6-3 | 185 | Right | Right | 6/22/1981 | 22 | Sylvania,Ohio | 2003 | 13 | 384 | BOS |
| 13 | Matt Blaney | P | A+ | 5-11 | 180 | Both | Right | 5/7/1979 | 24 | Vero Beach,Florida | 2001 | UDFA | | LAD |
| 32 | Brett Bonvechio | 1B | AA | 6-1 | 190 | Left | Right | 11/13/1982 | 20 | San Jose,California | 2000 | 37 | 1112 | BOS |
| 5 | Zach Borowiak | SS | AAA | 6-1 | 185 | Right | Right | 5/18/1981 | 22 | Centralia,Illinois | 2003 | 14 | 414 | BOS |
| 29 | Jim Buckley | C | AAA | 6-1 | 230 | Right | Right | 9/14/1979 | 23 | Kansas City,Missouri | 2002 | 25 | 748 | BOS |
| 2 | Erich Cloninger | C | A | 5-11 | 190 | Right | Right | 11/6/1980 | 22 | Catawba,North Carolina | 2003 | 35 | 1044 | BOS |
| 21 | Tom Cochran | P | AAA | 6-2 | 215 | Left | Left | 10/16/1982 | 20 | Wilmington,Delaware | 2003 | UDFA | | BOS |
| 47 | Dexter Cooper | P | A- | 6-2 | 210 | Right | Right | 7/14/1982 | 20 | Marietta,Georgia | 2001 | 15 | 465 | ATL |
| 22 | Jessie Corn | P | A- | 6-1 | 190 | Right | Right | 7/16/1982 | 20 | Lithia Springs,Georgia | 2003 | 6 | 174 | BOS |
| 24 | Rob Cucinotta | 1B | A- | 6-3 | 222 | Right | Right | 3/1/1980 | 23 | Lansdowne,Pennsylvania | 2003 | UDFA | | BOS |
| 19 | Jon Devries | C | AA | 6-3 | 200 | Right | Right | 8/22/1982 | 20 | Mission Viejo,California | 2001 | 3 | 93 | BOS |
| 12 | Bobb Evans | OF | A | 5-11 | 185 | Left | Left | 3/1/1981 | 22 | Birmingham,Alabama | 2000 | 23 | 694 | TEX |
| 31 | Chris Farley | P | AAA | 6-2 | 180 | Right | Right | 2/24/1983 | 20 | Greenfield,Massachusetts | 2001 | 14 | 423 | BOS |
| 36 | Jarrett Gardner | P | AA | 6-2 | 200 | Right | Right | 3/26/1981 | 22 | Norman,Oklahoma | 2003 | 19 | 564 | BOS |
| 30 | Barry Hertzler | P | AAA | 6-2 | 205 | Right | Right | 2/15/1981 | 22 | Providence,Rhode Island | 2003 | 11 | 324 | BOS |
| 34 | Kyle Jackson | P | AA | 6-3 | 180 | Right | Right | 4/9/1983 | 20 | Nashua,New Hampshire | 2001 | 32 | 963 | BOS |
| 15 | Scooter Jordan | OF | A | 5-8 | 160 | Left | Right | 12/15/1980 | 22 | Los Angeles,California | 2003 | 33 | 984 | BOS |
| - | Gabe Kapler | CF-RF | MLB | 6-2 | 208 | Right | Right | 8/31/1975 | 27 | Hollywood,California | 1995 | 57 | 1487 | DET |
| 44 | Wayne Lundgren | P | A+ | 6-7 | 220 | Right | Right | 4/21/1982 | 21 | Thornleigh,Australia | 2000 | UDFA | | BOS |
| 45 | Brian Marshall | P | AA | 6-5 | 185 | Left | Left | 8/30/1982 | 20 | Chesterfield,Virginia | 2003 | 5 | 144 | BOS |
| 3 | Brandon Moss | 1B | MLB | 6-0 | 180 | Left | Right | 9/16/1983 | 19 | Monroe,Georgia | 2002 | 8 | 238 | BOS |
| 32 | David Murphy | LF | MLB | 6-3 | 195 | Left | Left | 10/18/1981 | 21 | Houston,Texas | 2003 | 1 | 17 | BOS |
| 10 | Matt Murton | OF | MLB | 6-1 | 226 | Right | Right | 10/3/1981 | 21 | Fort Lauderdale,Florida | 2003 | 1 | 32 | BOS |
| 35 | Kevin Ool | P | AA | 5-10 | 180 | Left | Left | 1/4/1981 | 22 | Middletown,New York | 2003 | 16 | 474 | BOS |
| 23 | Jonathan Papelbon | P | MLB | 6-4 | 220 | Right | Right | 11/23/1980 | 22 | Baton Rouge,Louisiana | 2003 | 4 | 114 | BOS |
| 41 | Davey Penny | P | A | 6-3 | 210 | Right | Right | 9/9/1981 | 21 | Frankfurt,Germany | 2003 | 28 | 834 | BOS |
| 5 | Jason Ramos | SS | AA | 6-0 | 185 | Both | Right | 8/9/1982 | 20 | Miami,Florida | 2003 | 26 | 774 | BOS |
| 7 | Melvin Reyes | 2B | A- | 5-11 | 170 | Both | Right | 3/14/1983 | 20 | Moca,Dominican Republic | 2001 | UDFA | | BOS |
| 38 | David Sanders | P | AAA | 6-4 | 195 | Left | Left | 1/5/1982 | 21 | Anchorage,Alaska | 2003 | 30 | 894 | BOS |
| 28 | Arthur Santos | P | AA | 6-0 | 175 | Right | Right | 2/20/1982 | 21 | Miami,Florida | 2003 | 34 | 1014 | BOS |
| 38 | Lance Schartz | C | A | 6-0 | 215 | Right | Right | 1/26/1983 | 20 | Larned,Kansas | 2002 | 43 | 1287 | BOS |
| 14 | Brandon Smith | P | A | 6-3 | 196 | Right | Right | 2/18/1980 | 23 | Houston,Texas | 2002 | 18 | 538 | BOS |
| 37 | Justin Sturge | P | AA | 6-4 | 190 | Right | Left | 5/4/1981 | 22 | Syracuse,New York | 2003 | 12 | 354 | BOS |
| 6 | Iggy Suarez | SS | AAA | 5-11 | 165 | Right | Right | 5/3/1981 | 22 | New York,New York | 2003 | 24 | 714 | BOS |
| 16 | Jose Vaquedano | P | AAA | 6-4 | 175 | Right | Right | 7/9/1981 | 21 | La Ceiba,Honduras | 2002 | 35 | 1048 | BOS |
| 40 | Beau Vaughan | P | AAA | 6-4 | 230 | Both | Right | 6/4/1981 | 22 | Phoenix,Arizona | 2003 | 3 | 84 | BOS |
| 18 | Jeremy West | C | AA | 6-0 | 200 | Right | Right | 11/8/1981 | 21 | Las Vegas,Nevada | 2003 | 7 | 204 | BOS |