| 2002-04-01 | @ ARI | 1 | L 0-2 | 0-1 | 4 | 47,025 | Kevin Jarvis | Randy Johnson | Randy Johnson | Kevin Jarvis | | 0 | 2 | -2 |
| 2002-04-02 | @ ARI | 2 | L 0-9 | 0-2 | 5 | 48,042 | Brian Tollberg | Curt Schilling | Curt Schilling | Brian Tollberg | | 0 | 11 | -11 |
| 2002-04-03 | @ ARI | 3 | W 8-7 | 1-2 | 4 | 36,201 | Brian Lawrence | Brian Anderson | Jeremy Fikac | Mike Myers | Trevor Hoffman | 8 | 18 | -10 |
| 2002-04-05 | @ SFN | 4 | L 1-3 | 1-3 | 5 | 41,714 | Brett Tomko | Kirk Rueter | Tim Worrell | Steve Reed | | 9 | 21 | -12 |
| 2002-04-06 | @ SFN | 5 | L 1-4 | 1-4 | 5 | 40,894 | Kevin Jarvis | Kurt Ainsworth | Aaron Fultz | Kevin Jarvis | Robb Nen | 10 | 25 | -15 |
| 2002-04-07 | @ SFN | 6 | L 1-10 | 1-5 | 5 | 40,819 | Brian Tollberg | Livan Hernandez | Livan Hernandez | Brian Tollberg | | 11 | 35 | -24 |
| 2002-04-08 | vs ARI | 7 | W 8-0 | 2-5 | 5 | 59,103 | Brian Lawrence | Brian Anderson | Brian Lawrence | Brian Anderson | | 19 | 35 | -16 |
| 2002-04-09 | vs ARI | 8 | W 5-2 | 3-5 | 5 | 43,861 | Robert Joseph Jones | Todd Stottlemyre | Robert Joseph Jones | Todd Stottlemyre | Trevor Hoffman | 24 | 37 | -13 |
| 2002-04-10 | vs ARI | 9 | W 2-1 | 4-5 | 5 | 15,724 | Brett Tomko | Rick Helling | Alan Embree | Rick Helling | Trevor Hoffman | 26 | 38 | -12 |
| 2002-04-12 | vs LAN | 10 | L 0-3 | 4-6 | 4 | 31,894 | Kevin Jarvis | Kazuhisa Ishii | Kazuhisa Ishii | Kevin Jarvis | Eric Gagne | 26 | 41 | -15 |
| 2002-04-13 | vs LAN | 11 | W 6-4 | 5-6 | 4 | 47,893 | Brian Tollberg | Kevin Brown | Jeremy Fikac | Paul Quantrill | Trevor Hoffman | 32 | 45 | -13 |
| 2002-04-14 | vs LAN | 12 | W 1-0 | 6-6 | 4 | 46,410 | Brian Lawrence | Hideo Nomo | Brian Lawrence | Hideo Nomo | Trevor Hoffman | 33 | 45 | -12 |
| 2002-04-15 | vs SFN | 13 | W 4-3 | 7-6 | 4 | 14,675 | Robert Joseph Jones | Ryan Jensen | Alan Embree | Jason Christiansen | | 37 | 48 | -11 |
| 2002-04-16 | vs SFN | 14 | L 1-5 | 7-7 | 4 | 20,930 | Brett Tomko | Kirk Rueter | Kirk Rueter | Brett Tomko | | 38 | 53 | -15 |
| 2002-04-17 | vs SFN | 15 | W 5-3 | 8-7 | 4 | 22,438 | Kevin Jarvis | Kurt Ainsworth | Kevin Jarvis | Kurt Ainsworth | Trevor Hoffman | 43 | 56 | -13 |
| 2002-04-18 | @ LAN | 16 | L 2-5 | 8-8 | 4 | 24,434 | Brian Tollberg | Omar Daal | Omar Daal | Brian Tollberg | Eric Gagne | 45 | 61 | -16 |
| 2002-04-19 | @ LAN | 17 | L 2-5 | 8-9 | 4 | 47,425 | Brian Lawrence | Hideo Nomo | Hideo Nomo | Brian Lawrence | Eric Gagne | 47 | 66 | -19 |
| 2002-04-20 | @ LAN | 18 | L 1-4 | 8-10 | 4 | 41,000 | Robert Joseph Jones | Odalis Perez | Odalis Perez | Robert Joseph Jones | Giovanni Carrara | 48 | 70 | -22 |
| 2002-04-21 | @ LAN | 19 | W 5-0 | 9-10 | 4 | 48,469 | Brett Tomko | Andy Ashby | Brett Tomko | Andy Ashby | | 53 | 70 | -17 |
| 2002-04-23 | @ PHI | 20 | L 5-8 | 9-11 | 4 | 12,138 | Brian Tollberg | Randy Wolf | Randy Wolf | Matt DeWitt | Jose Mesa | 58 | 78 | -20 |
| 2002-04-24 | @ PHI | 21 | W 7-2 | 10-11 | 4 | 12,250 | Brian Lawrence | Robert Person | Brian Lawrence | Robert Person | | 65 | 80 | -15 |
| 2002-04-25 | @ PHI | 22 | W 6-4 | 11-11 | 4 | 12,249 | Robert Joseph Jones | Vicente Padilla | Robert Joseph Jones | Rheal Cormier | Trevor Hoffman | 71 | 84 | -13 |
| 2002-04-26 | @ PIT | 23 | W 10-1 | 12-11 | 4 | 20,575 | Brett Tomko | Ron Villone | Brett Tomko | Ron Villone | | 81 | 85 | -4 |
| 2002-04-28 | @ PIT | 24 | L 2-3 | 13-12 | 4 | 0 | Ben Howard | Kip Wells | Scott Sauerbeck | Alan Embree | Mike Williams | 83 | 88 | -5 |
| 2002-04-28 | @ PIT | 25 | W 7-2 | 13-12 | 4 | 19,621 | Brian Tollberg | Jimmy Anderson | Brian Tollberg | Jimmy Anderson | | 90 | 90 | 0 |
| 2002-04-30 | vs CHN | 26 | W 2-1 | 14-12 | 4 | 20,389 | Brian Lawrence | Matt Clement | Jeremy Fikac | Joe Borowski | Trevor Hoffman | 92 | 91 | 1 |
| 2002-05-01 | vs CHN | 27 | W 4-3 | 15-12 | 4 | 18,071 | Robert Joseph Jones | Jon Lieber | Robert Joseph Jones | Jon Lieber | Trevor Hoffman | 96 | 94 | 2 |
| 2002-05-02 | vs CHN | 28 | L 1-6 | 15-13 | 4 | 31,651 | Brett Tomko | Kerry Wood | Kerry Wood | Brett Tomko | | 97 | 100 | -3 |
| 2002-05-03 | vs PIT | 29 | L 4-6 | 15-14 | 4 | 20,312 | Ben Howard | Kip Wells | Kip Wells | Ben Howard | Mike Williams | 101 | 106 | -5 |
| 2002-05-04 | vs PIT | 30 | W 3-0 | 16-14 | 4 | 36,972 | Kevin Jarvis | Jimmy Anderson | Kevin Jarvis | Jimmy Anderson | Trevor Hoffman | 104 | 106 | -2 |
| 2002-05-05 | vs PIT | 31 | W 6-5 | 17-14 | 4 | 27,399 | Brian Lawrence | Sean Lowe | Brian Lawrence | Sean Lowe | Trevor Hoffman | 110 | 111 | -1 |
| 2002-05-07 | @ FLO | 32 | L 4-12 | 17-15 | 4 | 6,098 | Robert Joseph Jones | Ryan Dempster | Ryan Dempster | Robert Joseph Jones | | 114 | 123 | -9 |
| 2002-05-08 | @ FLO | 33 | L 4-7 | 17-16 | 4 | 6,915 | Brett Tomko | Kevin Olsen | Oswaldo Mairena | Jeremy Fikac | Vladimir Nunez | 118 | 130 | -12 |
| 2002-05-09 | @ FLO | 34 | L 0-1 | 17-17 | 4 | 5,461 | Brian Tollberg | Hansel Izquierdo | Hansel Izquierdo | Brian Tollberg | Vladimir Nunez | 118 | 131 | -13 |
| 2002-05-10 | @ ATL | 35 | L 3-7 | 17-18 | 4 | 29,075 | Dennis Tankersley | Greg Maddux | Mike Remlinger | Jeremy Fikac | | 121 | 138 | -17 |
| 2002-05-11 | @ ATL | 36 | L 1-6 | 17-19 | 4 | 36,273 | Brian Lawrence | Jason Marquis | Jason Marquis | Brian Lawrence | | 122 | 144 | -22 |
| 2002-05-12 | @ ATL | 37 | W 6-5 | 18-19 | 4 | 25,636 | Robert Joseph Jones | Tom Glavine | Jason Boyd | Tom Glavine | Trevor Hoffman | 128 | 149 | -21 |
| 2002-05-13 | vs MON | 38 | W 7-3 | 19-19 | 4 | 27,865 | Brett Tomko | Carl Pavano | Brett Tomko | Carl Pavano | | 135 | 152 | -17 |
| 2002-05-14 | vs MON | 39 | W 5-4 | 20-19 | 4 | 13,323 | Brian Tollberg | Bruce Chen | Trevor Hoffman | Scott Stewart | | 140 | 156 | -16 |
| 2002-05-15 | vs MON | 40 | W 2-1 | 21-19 | 4 | 12,402 | Dennis Tankersley | Javier Vazquez | Alan Embree | Joey Eischen | | 142 | 157 | -15 |
| 2002-05-16 | vs NYN | 41 | L 1-3 | 21-20 | 4 | 15,931 | Brian Lawrence | Al Leiter | Al Leiter | Brian Lawrence | Mark Guthrie | 143 | 160 | -17 |
| 2002-05-17 | vs NYN | 42 | L 4-13 | 21-21 | 4 | 28,162 | Jason Middlebrook | Steve Trachsel | Steve Trachsel | Jason Middlebrook | | 147 | 173 | -26 |
| 2002-05-18 | vs NYN | 43 | L 2-5 | 21-22 | 4 | 43,282 | Brett Tomko | Shawn Estes | Shawn Estes | Brett Tomko | Armando Benitez | 149 | 178 | -29 |
| 2002-05-19 | vs NYN | 44 | W 4-3 | 22-22 | 4 | 26,254 | Brian Tollberg | Pedro Astacio | Steve Reed | Scott Strickland | | 153 | 181 | -28 |
| 2002-05-21 | @ COL | 45 | L 6-7 | 22-23 | 4 | 30,616 | Dennis Tankersley | Jason Jennings | Justin Speier | Alan Embree | Jose Jimenez | 159 | 188 | -29 |
| 2002-05-22 | @ COL | 46 | L 3-5 | 22-24 | 5 | 29,204 | Brian Lawrence | Mike Hampton | Kent Mercker | Jeremy Fikac | Jose Jimenez | 162 | 193 | -31 |
| 2002-05-23 | @ COL | 47 | L 3-16 | 22-25 | 5 | 30,701 | Brett Tomko | John Thomson | John Thomson | Brett Tomko | | 165 | 209 | -44 |
| 2002-05-24 | @ MIL | 48 | L 2-6 | 22-26 | 5 | 18,857 | Brian Tollberg | Jamey Wright | Jamey Wright | Brian Tollberg | | 167 | 215 | -48 |
| 2002-05-25 | @ MIL | 49 | L 0-2 | 22-27 | 5 | 25,658 | Kevin Pickford | Ruben Quevedo | Ruben Quevedo | Kevin Pickford | | 167 | 217 | -50 |
| 2002-05-26 | @ MIL | 50 | W 8-7 | 23-27 | 5 | 27,007 | Dennis Tankersley | Nelson Figueroa | Dennis Tankersley | Nelson Figueroa | Trevor Hoffman | 175 | 224 | -49 |
| 2002-05-27 | vs COL | 51 | W 8-5 | 24-27 | 5 | 15,666 | Brian Lawrence | Mike Hampton | Brian Lawrence | Mike Hampton | Trevor Hoffman | 183 | 229 | -46 |
| 2002-05-28 | vs COL | 52 | L 2-3 | 24-28 | 5 | 13,998 | Brett Tomko | John Thomson | Jose Jimenez | Jeremy Fikac | Justin Speier | 185 | 232 | -47 |
| 2002-05-29 | vs COL | 53 | W 11-3 | 25-28 | 5 | 13,421 | Brian Tollberg | Denny Stark | Jason Middlebrook | Denny Stark | | 196 | 235 | -39 |
| 2002-05-30 | vs COL | 54 | L 2-4 | 25-29 | 5 | 18,755 | Robert Joseph Jones | Denny Neagle | Denny Neagle | Robert Joseph Jones | Jose Jimenez | 198 | 239 | -41 |
| 2002-05-31 | vs MIL | 55 | L 1-12 | 25-30 | 5 | 56,167 | Dennis Tankersley | Ruben Quevedo | Ruben Quevedo | Dennis Tankersley | | 199 | 251 | -52 |
| 2002-06-01 | vs MIL | 56 | L 3-4 | 25-31 | 5 | 35,944 | Brian Lawrence | Ben Sheets | Luis Vizcaino | Alan Embree | Mike DeJean | 202 | 255 | -53 |
| 2002-06-02 | vs MIL | 57 | L 3-4 | 25-32 | 5 | 19,401 | Brett Tomko | Glendon Rusch | Chad Fox | Steve Reed | Mike DeJean | 205 | 259 | -54 |
| 2002-06-03 | vs SFN | 58 | L 3-11 | 25-33 | 5 | 16,534 | Jason Middlebrook | Russ Ortiz | Russ Ortiz | Jason Middlebrook | | 208 | 270 | -62 |
| 2002-06-04 | vs SFN | 59 | L 1-3 | 25-34 | 5 | 23,567 | Robert Joseph Jones | Kirk Rueter | Kirk Rueter | Robert Joseph Jones | Robb Nen | 209 | 273 | -64 |
| 2002-06-05 | vs SFN | 60 | L 2-12 | 25-35 | 5 | 21,498 | Dennis Tankersley | Ryan Jensen | Ryan Jensen | Dennis Tankersley | | 211 | 285 | -74 |
| 2002-06-07 | @ TBA | 61 | W 8-4 | 26-35 | 5 | 10,578 | Brian Lawrence | Ryan Rupe | Brian Lawrence | Ryan Rupe | | 219 | 289 | -70 |
| 2002-06-08 | @ TBA | 62 | L 2-3 | 26-36 | 5 | 14,039 | Brett Tomko | Tanyon Sturtze | Victor Zambrano | Alan Embree | | 221 | 292 | -71 |
| 2002-06-09 | @ TBA | 63 | W 9-6 | 27-36 | 5 | 13,286 | Robert Joseph Jones | Paul Wilson | Robert Joseph Jones | Paul Wilson | Trevor Hoffman | 230 | 298 | -68 |
| 2002-06-10 | @ BAL | 64 | L 6-8 | 27-37 | 5 | 30,075 | Dennis Tankersley | Scott Erickson | Buddy Groom | Jeremy Fikac | Jorge Julio | 236 | 306 | -70 |
| 2002-06-11 | @ BAL | 65 | L 5-6 | 27-38 | 5 | 32,829 | Kevin Pickford | Travis Driskill | Jorge Julio | J.J. Trujillo | | 241 | 312 | -71 |
| 2002-06-12 | @ BAL | 66 | W 2-0 | 28-38 | 5 | 28,272 | Brian Lawrence | Rodrigo Lopez | Brian Lawrence | Rodrigo Lopez | Trevor Hoffman | 243 | 312 | -69 |
| 2002-06-14 | vs SEA | 67 | L 3-6 | 28-39 | 5 | 26,098 | Brett Tomko | Freddy Garcia | Freddy Garcia | Brett Tomko | Kazuhiro Sasaki | 246 | 318 | -72 |
| 2002-06-15 | vs SEA | 68 | W 3-1 | 29-39 | 5 | 39,001 | Robert Joseph Jones | Rafael Soriano | Robert Joseph Jones | Rafael Soriano | Trevor Hoffman | 249 | 319 | -70 |
| 2002-06-16 | vs SEA | 69 | W 5-3 | 30-39 | 5 | 30,784 | Oliver Perez | Jamie Moyer | Oliver Perez | Jamie Moyer | Trevor Hoffman | 254 | 322 | -68 |
| 2002-06-18 | vs BOS | 70 | L 2-4 | 30-40 | 5 | 30,212 | Brian Lawrence | Rolando Arrojo | Willie Banks | Brian Lawrence | Ugueth Urbina | 256 | 326 | -70 |
| 2002-06-19 | vs BOS | 71 | W 3-2 | 31-40 | 5 | 32,974 | Brett Tomko | Frank Castillo | Brett Tomko | Frank Castillo | Trevor Hoffman | 259 | 328 | -69 |
| 2002-06-20 | vs BOS | 72 | L 0-5 | 31-41 | 5 | 35,346 | Kevin Pickford | Pedro Martinez | Pedro Martinez | Kevin Pickford | | 259 | 333 | -74 |
| 2002-06-21 | vs NYA | 73 | W 9-1 | 32-41 | 5 | 55,858 | Oliver Perez | David Wells | Oliver Perez | David Wells | | 268 | 334 | -66 |
| 2002-06-22 | vs NYA | 74 | L 0-1 | 32-42 | 5 | 60,021 | Jake Peavy | Ted Lilly | Ted Lilly | Jake Peavy | | 268 | 335 | -67 |
| 2002-06-23 | vs NYA | 75 | L 2-3 | 32-43 | 5 | 50,050 | Brian Lawrence | Mike Mussina | Ramiro Mendoza | Steve Reed | Steve Karsay | 270 | 338 | -68 |
| 2002-06-24 | vs SFN | 76 | L 6-7 | 32-44 | 5 | 17,475 | Brett Tomko | Jason Schmidt | Tim Worrell | Trevor Hoffman | Robb Nen | 276 | 345 | -69 |
| 2002-06-25 | vs SFN | 77 | W 10-7 | 33-44 | 5 | 15,856 | Kevin Pickford | Russ Ortiz | Rodney Myers | Felix Rodriguez | Trevor Hoffman | 286 | 352 | -66 |
| 2002-06-26 | @ SFN | 78 | L 5-6 | 33-45 | 5 | 40,037 | Oliver Perez | Kirk Rueter | Jay Witasick | Rodney Myers | | 291 | 358 | -67 |
| 2002-06-27 | @ SFN | 79 | L 6-11 | 33-46 | 5 | 39,519 | Kevin Jarvis | Ryan Jensen | Ryan Jensen | Jason Middlebrook | Robb Nen | 297 | 369 | -72 |
| 2002-06-28 | @ KCA | 80 | L 10-14 | 33-47 | 5 | 29,935 | Brian Lawrence | Miguel Asencio | Jason Grimsley | Eric Cyr | | 307 | 383 | -76 |
| 2002-06-29 | @ KCA | 81 | W 8-4 | 34-47 | 5 | 27,441 | Brett Tomko | Shawn Sedlacek | Steve Reed | Jason Grimsley | | 315 | 387 | -72 |
| 2002-06-30 | @ KCA | 82 | L 1-13 | 34-48 | 5 | 22,073 | Jake Peavy | Jeff Suppan | Jeff Suppan | Jake Peavy | | 316 | 400 | -84 |
| 2002-07-01 | @ SLN | 83 | L 3-7 | 34-49 | 5 | 30,113 | Oliver Perez | Woody Williams | Woody Williams | Oliver Perez | | 319 | 407 | -88 |
| 2002-07-02 | @ SLN | 84 | L 5-11 | 34-50 | 5 | 29,622 | Kevin Jarvis | Bud Smith | Mike Crudale | Kevin Jarvis | | 324 | 418 | -94 |
| 2002-07-03 | @ SLN | 85 | L 1-4 | 34-51 | 5 | 41,533 | Brian Lawrence | Jason Simontacchi | Jason Simontacchi | Brian Lawrence | Jason Isringhausen | 325 | 422 | -97 |
| 2002-07-05 | @ COL | 86 | L 6-9 | 34-52 | 5 | 48,540 | Brett Tomko | Mike Hampton | Mike Hampton | Brett Tomko | Jose Jimenez | 331 | 431 | -100 |
| 2002-07-06 | @ COL | 87 | L 2-3 | 34-53 | 5 | 36,866 | Jake Peavy | John Thomson | John Thomson | Jake Peavy | Jose Jimenez | 333 | 434 | -101 |
| 2002-07-07 | @ COL | 88 | W 7-1 | 35-53 | 5 | 30,707 | Oliver Perez | Shawn Chacon | Oliver Perez | Shawn Chacon | | 340 | 435 | -95 |
| 2002-07-12 | vs SLN | 89 | W 4-3 | 36-53 | 5 | 23,794 | Brian Lawrence | Jason Simontacchi | Mike Holtz | Dave Veres | Trevor Hoffman | 344 | 438 | -94 |
| 2002-07-13 | vs SLN | 90 | L 1-2 | 36-54 | 5 | 48,963 | Brett Tomko | Matt Morris | Mike Crudale | Steve Reed | Jason Isringhausen | 345 | 440 | -95 |
| 2002-07-14 | vs SLN | 91 | L 1-4 | 36-55 | 5 | 24,045 | Robert Joseph Jones | Bud Smith | Bud Smith | Robert Joseph Jones | Jason Isringhausen | 346 | 444 | -98 |
| 2002-07-15 | vs COL | 92 | L 0-5 | 36-56 | 5 | 37,827 | Oliver Perez | Denny Stark | Denny Stark | Oliver Perez | | 346 | 449 | -103 |
| 2002-07-16 | vs COL | 93 | W 5-1 | 37-56 | 5 | 22,150 | Jake Peavy | Jason Jennings | Jake Peavy | Jason Jennings | Steve Reed | 351 | 450 | -99 |
| 2002-07-17 | @ LAN | 94 | W 7-0 | 38-56 | 5 | 33,778 | Brian Lawrence | Odalis Perez | Brian Lawrence | Odalis Perez | | 358 | 450 | -92 |
| 2002-07-18 | @ LAN | 95 | W 4-1 | 39-56 | 5 | 53,662 | Brett Tomko | Andy Ashby | Brett Tomko | Andy Ashby | Trevor Hoffman | 362 | 451 | -89 |
| 2002-07-19 | vs ARI | 96 | W 6-1 | 40-56 | 5 | 27,803 | Robert Joseph Jones | Miguel Batista | Robert Joseph Jones | Miguel Batista | | 368 | 452 | -84 |
| 2002-07-20 | vs ARI | 97 | L 1-7 | 40-57 | 5 | 54,980 | Oliver Perez | John Patterson | Mike Myers | Mike Holtz | | 369 | 459 | -90 |
| 2002-07-21 | vs ARI | 98 | W 11-9 | 41-57 | 5 | 36,118 | Jake Peavy | Randy Johnson | Jake Peavy | Randy Johnson | Trevor Hoffman | 380 | 468 | -88 |
| 2002-07-22 | vs LAN | 99 | W 5-2 | 42-57 | 5 | 20,085 | Brian Lawrence | Odalis Perez | Brian Lawrence | Odalis Perez | Trevor Hoffman | 385 | 470 | -85 |
| 2002-07-23 | vs LAN | 100 | L 6-8 | 42-58 | 5 | 25,680 | Brett Tomko | Andy Ashby | Giovanni Carrara | Jeremy Fikac | Eric Gagne | 391 | 478 | -87 |
| 2002-07-24 | vs LAN | 101 | W 8-0 | 43-58 | 5 | 26,779 | Robert Joseph Jones | Kazuhisa Ishii | Robert Joseph Jones | Kazuhisa Ishii | | 399 | 478 | -79 |
| 2002-07-25 | @ ARI | 102 | L 0-10 | 43-59 | 5 | 35,200 | Oliver Perez | John Patterson | John Patterson | Oliver Perez | | 399 | 488 | -89 |
| 2002-07-26 | @ ARI | 103 | L 0-12 | 43-60 | 5 | 41,569 | Jake Peavy | Randy Johnson | Randy Johnson | Jake Peavy | | 399 | 500 | -101 |
| 2002-07-27 | @ ARI | 104 | L 3-4 | 43-61 | 5 | 45,407 | Brian Lawrence | Curt Schilling | Curt Schilling | Brian Lawrence | | 402 | 504 | -102 |
| 2002-07-28 | @ ARI | 105 | L 4-5 | 43-62 | 5 | 40,003 | Brett Tomko | Brian Anderson | Mike Koplove | Trevor Hoffman | | 406 | 509 | -103 |
| 2002-07-30 | @ CHN | 106 | W 6-5 | 44-62 | 5 | 39,819 | Robert Joseph Jones | Mark Prior | Mike Holtz | Tom Gordon | Trevor Hoffman | 412 | 514 | -102 |
| 2002-07-31 | @ CHN | 107 | W 8-6 | 45-62 | 5 | 34,483 | Oliver Perez | Carlos Zambrano | Brandon Villafuerte | Kyle Farnsworth | Trevor Hoffman | 420 | 520 | -100 |
| 2002-08-01 | @ CHN | 108 | L 7-8 | 45-63 | 5 | 33,751 | Jake Peavy | Jon Lieber | Tom Gordon | Trevor Hoffman | | 427 | 528 | -101 |
| 2002-08-02 | vs CIN | 109 | W 5-2 | 46-63 | 5 | 25,548 | Brian Lawrence | Jared Fernandez | Brian Lawrence | Jared Fernandez | Trevor Hoffman | 432 | 530 | -98 |
| 2002-08-03 | vs CIN | 110 | L 3-4 | 46-64 | 5 | 39,341 | Brett Tomko | Jimmy Haynes | Jimmy Haynes | Brett Tomko | Danny Graves | 435 | 534 | -99 |
| 2002-08-04 | vs CIN | 111 | L 10-15 | 46-65 | 5 | 25,871 | Robert Joseph Jones | Ryan Dempster | Gabe White | Trevor Hoffman | | 445 | 549 | -104 |
| 2002-08-06 | vs PHI | 112 | L 4-5 | 46-66 | 5 | 17,519 | Oliver Perez | Randy Wolf | Rheal Cormier | Robert Joseph Jones | | 449 | 554 | -105 |
| 2002-08-07 | vs PHI | 113 | W 5-2 | 47-66 | 5 | 18,583 | Jake Peavy | Vicente Padilla | Jake Peavy | Vicente Padilla | Trevor Hoffman | 454 | 556 | -102 |
| 2002-08-08 | vs PHI | 114 | W 7-4 | 48-66 | 5 | 22,076 | Brian Lawrence | Joe Roa | Tom Davey | Terry Adams | | 461 | 560 | -99 |
| 2002-08-09 | @ CIN | 115 | L 10-12 | 48-67 | 5 | 22,708 | Brett Tomko | Jared Fernandez | John Riedling | Brett Tomko | | 471 | 572 | -101 |
| 2002-08-10 | @ CIN | 116 | L 0-9 | 48-68 | 5 | 40,814 | Robert Joseph Jones | Ryan Dempster | Ryan Dempster | Robert Joseph Jones | | 471 | 581 | -110 |
| 2002-08-11 | @ CIN | 117 | L 7-9 | 48-69 | 5 | 28,657 | Robert Mitchell Jones | Brian Moehler | Jose Rijo | Brandon Villafuerte | | 478 | 590 | -112 |
| 2002-08-13 | @ NYN | 118 | W 7-2 | 49-69 | 5 | 31,672 | Jake Peavy | Steve Trachsel | Jake Peavy | Steve Trachsel | Trevor Hoffman | 485 | 592 | -107 |
| 2002-08-14 | @ NYN | 119 | W 6-2 | 50-69 | 5 | 26,210 | Brian Lawrence | Al Leiter | Brian Lawrence | Al Leiter | Trevor Hoffman | 491 | 594 | -103 |
| 2002-08-15 | @ NYN | 120 | W 5-3 | 51-69 | 5 | 27,182 | Brett Tomko | John Thomson | Brett Tomko | John Thomson | Trevor Hoffman | 496 | 597 | -101 |
| 2002-08-16 | @ MON | 121 | L 6-11 | 51-70 | 5 | 7,564 | Robert Mitchell Jones | Masato Yoshii | Zach Day | Jason Kershner | | 502 | 608 | -106 |
| 2002-08-17 | @ MON | 122 | W 6-5 | 52-70 | 5 | 9,121 | Mike Bynum | Britt Reames | Jonathan Johnson | Matt Herges | Trevor Hoffman | 508 | 613 | -105 |
| 2002-08-18 | @ MON | 123 | L 2-9 | 52-71 | 5 | 24,872 | Jake Peavy | Tomo Ohka | Tomo Ohka | Jake Peavy | | 510 | 622 | -112 |
| 2002-08-19 | @ MON | 124 | L 0-4 | 52-72 | 5 | 8,266 | Brian Lawrence | Bartolo Colon | Bartolo Colon | Brian Lawrence | | 510 | 626 | -116 |
| 2002-08-20 | vs ATL | 125 | W 6-2 | 53-72 | 5 | 21,440 | Brett Tomko | Damian Moss | Brett Tomko | Damian Moss | | 516 | 628 | -112 |
| 2002-08-21 | vs ATL | 126 | L 3-6 | 53-73 | 5 | 22,471 | Dennis Tankersley | Kevin Millwood | Kevin Millwood | Dennis Tankersley | John Smoltz | 519 | 634 | -115 |
| 2002-08-22 | vs ATL | 127 | W 9-2 | 54-73 | 5 | 23,569 | Mike Bynum | Jason Marquis | Mike Bynum | Jason Marquis | | 528 | 636 | -108 |
| 2002-08-23 | vs FLO | 128 | W 18-2 | 55-73 | 5 | 21,964 | Jake Peavy | Carl Pavano | Jake Peavy | Carl Pavano | | 546 | 638 | -92 |
| 2002-08-24 | vs FLO | 129 | L 4-8 | 55-74 | 5 | 25,489 | Brian Lawrence | Julian Tavarez | Julian Tavarez | Brian Lawrence | | 550 | 646 | -96 |
| 2002-08-25 | vs FLO | 130 | L 6-7 | 55-75 | 5 | 22,448 | Brett Tomko | Brad Penny | Toby Borland | Brandon Villafuerte | Braden Looper | 556 | 653 | -97 |
| 2002-08-27 | @ HOU | 131 | W 11-6 | 56-75 | 5 | 21,771 | Mike Bynum | Carlos Hernandez | Jeremy Fikac | Dave Mlicki | | 567 | 659 | -92 |
| 2002-08-28 | @ HOU | 132 | L 1-2 | 56-76 | 5 | 25,339 | Jake Peavy | Roy Oswalt | Roy Oswalt | Jake Peavy | Billy Wagner | 568 | 661 | -93 |
| 2002-08-29 | @ HOU | 133 | L 0-5 | 56-77 | 5 | 22,485 | Brian Lawrence | Peter Munro | Peter Munro | Brian Lawrence | Octavio Dotel | 568 | 666 | -98 |
| 2002-08-30 | vs COL | 134 | W 2-0 | 57-77 | 5 | 15,987 | Brett Tomko | Denny Neagle | Brett Tomko | Denny Neagle | Trevor Hoffman | 570 | 666 | -96 |
| 2002-08-31 | vs COL | 135 | W 3-0 | 58-77 | 5 | 31,043 | Clay Condrey | Aaron Cook | Clay Condrey | Aaron Cook | Trevor Hoffman | 573 | 666 | -93 |
| 2002-09-01 | vs COL | 136 | W 9-5 | 59-77 | 5 | 21,190 | Adam Eaton | Denny Stark | Doug Nickle | Victor Santos | Trevor Hoffman | 582 | 671 | -89 |
| 2002-09-02 | vs COL | 137 | L 2-5 | 59-78 | 5 | 31,837 | Robert Joseph Jones | Jason Jennings | Jason Jennings | Robert Joseph Jones | Jose Jimenez | 584 | 676 | -92 |
| 2002-09-03 | vs HOU | 138 | L 2-6 | 59-79 | 5 | 14,562 | Brian Lawrence | Roy Oswalt | Roy Oswalt | Brian Lawrence | Billy Wagner | 586 | 682 | -96 |
| 2002-09-04 | vs HOU | 139 | W 5-1 | 60-79 | 5 | 15,147 | Brett Tomko | Peter Munro | Brett Tomko | Peter Munro | | 591 | 683 | -92 |
| 2002-09-05 | vs HOU | 140 | L 0-5 | 60-80 | 5 | 12,849 | Jake Peavy | Wade Miller | Billy Wagner | Jonathan Johnson | | 591 | 688 | -97 |
| 2002-09-06 | @ COL | 141 | L 3-7 | 60-81 | 5 | 26,243 | Adam Eaton | Aaron Cook | Aaron Cook | Adam Eaton | | 594 | 695 | -101 |
| 2002-09-07 | @ COL | 142 | L 3-5 | 60-82 | 5 | 26,444 | Oliver Perez | Denny Stark | Kent Mercker | Mike Holtz | Jose Jimenez | 597 | 700 | -103 |
| 2002-09-08 | @ COL | 143 | W 9-4 | 61-82 | 5 | 25,706 | Brian Lawrence | Jason Jennings | Brian Lawrence | Jason Jennings | Trevor Hoffman | 606 | 704 | -98 |
| 2002-09-09 | @ ARI | 144 | L 2-5 | 61-83 | 5 | 30,486 | Brett Tomko | Randy Johnson | Randy Johnson | Brett Tomko | Byung-Hyun Kim | 608 | 709 | -101 |
| 2002-09-10 | @ ARI | 145 | L 2-8 | 61-84 | 5 | 33,382 | Jake Peavy | Curt Schilling | Curt Schilling | Jake Peavy | | 610 | 717 | -107 |
| 2002-09-11 | @ ARI | 146 | L 5-6 | 61-85 | 5 | 34,217 | Adam Eaton | Miguel Batista | Mike Koplove | Kevin Walker | Mike Myers | 615 | 723 | -108 |
| 2002-09-12 | vs SFN | 147 | W 3-2 | 62-85 | 5 | 16,143 | Oliver Perez | Ryan Jensen | Trevor Hoffman | Tim Worrell | | 618 | 725 | -107 |
| 2002-09-13 | vs SFN | 148 | L 3-10 | 62-86 | 5 | 25,857 | Brian Lawrence | Russ Ortiz | Russ Ortiz | Brian Lawrence | | 621 | 735 | -114 |
| 2002-09-14 | @ SFN | 149 | L 4-12 | 62-87 | 5 | 41,506 | Brett Tomko | Livan Hernandez | Livan Hernandez | Brett Tomko | | 625 | 747 | -122 |
| 2002-09-15 | @ SFN | 150 | W 4-1 | 63-87 | 5 | 41,116 | Jake Peavy | Kurt Ainsworth | Jake Peavy | Kurt Ainsworth | Trevor Hoffman | 629 | 748 | -119 |
| 2002-09-17 | vs ARI | 151 | W 3-2 | 64-87 | 5 | 17,857 | Adam Eaton | Miguel Batista | Adam Eaton | Miguel Batista | Trevor Hoffman | 632 | 750 | -118 |
| 2002-09-18 | vs ARI | 152 | L 3-10 | 64-88 | 5 | 17,288 | Oliver Perez | Rick Helling | Rick Helling | Oliver Perez | | 635 | 760 | -125 |
| 2002-09-19 | vs ARI | 153 | L 1-3 | 64-89 | 5 | 15,540 | Clay Condrey | Randy Johnson | Randy Johnson | Clay Condrey | Byung-Hyun Kim | 636 | 763 | -127 |
| 2002-09-20 | vs LAN | 154 | W 8-4 | 65-89 | 5 | 23,595 | Brett Tomko | Andy Ashby | Brett Tomko | Andy Ashby | | 644 | 767 | -123 |
| 2002-09-21 | vs LAN | 155 | L 3-5 | 65-90 | 5 | 48,208 | Jake Peavy | Hideo Nomo | Hideo Nomo | Trevor Hoffman | Eric Gagne | 647 | 772 | -125 |
| 2002-09-22 | vs LAN | 156 | L 3-4 | 65-91 | 5 | 26,017 | Adam Eaton | Omar Daal | Paul Quantrill | Jonathan Johnson | Eric Gagne | 650 | 776 | -126 |
| 2002-09-24 | @ SFN | 157 | L 3-12 | 65-92 | 5 | 37,772 | Oliver Perez | Russ Ortiz | Russ Ortiz | Oliver Perez | | 653 | 788 | -135 |
| 2002-09-25 | @ SFN | 158 | L 0-6 | 65-93 | 5 | 38,001 | Clay Condrey | Livan Hernandez | Livan Hernandez | Clay Condrey | | 653 | 794 | -141 |
| 2002-09-26 | @ LAN | 159 | L 5-6 | 65-94 | 5 | 29,613 | Jake Peavy | Hideo Nomo | Paul Shuey | Brian Lawrence | Eric Gagne | 658 | 800 | -142 |
| 2002-09-27 | @ LAN | 160 | L 0-1 | 65-95 | 5 | 45,801 | Adam Eaton | Omar Daal | Eric Gagne | Jeremy Fikac | | 658 | 801 | -143 |
| 2002-09-28 | @ LAN | 161 | L 2-14 | 65-96 | 5 | 33,664 | Dennis Tankersley | Kevin Beirne | Kevin Beirne | Dennis Tankersley | | 660 | 815 | -155 |
| 2002-09-29 | @ LAN | 162 | W 2-0 | 66-96 | 5 | 49,168 | Oliver Perez | Victor Alvarez | Oliver Perez | Victor Alvarez | Brandon Villafuerte | 662 | 815 | -153 |