| 2002-04-01 | @ KCA | 1 | W 8-6 | 1-0 | 3 | 40,605 | Brad Radke | Jeff Suppan | J.C. Romero | Cory Bailey | Eddie Guardado | 8 | 6 | 2 |
| 2002-04-03 | @ KCA | 2 | W 1-0 | 2-0 | 1 | 10,856 | Eric Milton | Dan Reichert | Eric Milton | Dan Reichert | Eddie Guardado | 9 | 6 | 3 |
| 2002-04-04 | @ TOR | 3 | L 2-7 | 2-1 | 2 | 47,469 | Joe Mays | Roy Halladay | Roy Halladay | Joe Mays | | 11 | 13 | -2 |
| 2002-04-05 | @ TOR | 4 | W 4-3 | 3-1 | 2 | 15,784 | Rick Reed | Brandon Lyon | Rick Reed | Brandon Lyon | Eddie Guardado | 15 | 16 | -1 |
| 2002-04-06 | @ TOR | 5 | W 7-5 | 4-1 | 2 | 18,947 | Kyle Lohse | Scott Eyre | LaTroy Hawkins | Scott Eyre | Eddie Guardado | 22 | 21 | 1 |
| 2002-04-07 | @ TOR | 6 | W 10-6 | 5-1 | 2 | 21,071 | Brad Radke | Brian Cooper | Brad Radke | Brian Cooper | | 32 | 27 | 5 |
| 2002-04-08 | @ CLE | 7 | L 5-9 | 5-2 | 2 | 42,441 | Eric Milton | Ryan Drese | Ryan Drese | Eric Milton | | 37 | 36 | 1 |
| 2002-04-09 | @ CLE | 8 | L 4-5 | 5-3 | 2 | 23,760 | Joe Mays | Chuck Finley | Chuck Finley | Joe Mays | Bob Wickman | 41 | 41 | 0 |
| 2002-04-10 | @ CLE | 9 | L 3-9 | 5-4 | 2 | 25,420 | Rick Reed | Danys Baez | Danys Baez | Rick Reed | | 44 | 50 | -6 |
| 2002-04-11 | @ CLE | 10 | L 4-8 | 5-5 | 4 | 25,582 | Kyle Lohse | Bartolo Colon | Bartolo Colon | Kyle Lohse | | 48 | 58 | -10 |
| 2002-04-12 | vs DET | 11 | W 4-2 | 6-5 | 3 | 48,244 | Brad Radke | Mark Redman | Brad Radke | Mark Redman | Eddie Guardado | 52 | 60 | -8 |
| 2002-04-13 | vs DET | 12 | W 7-3 | 7-5 | 3 | 25,268 | Eric Milton | Jeff Weaver | Eric Milton | Jeff Weaver | | 59 | 63 | -4 |
| 2002-04-14 | vs DET | 13 | W 13-7 | 8-5 | 2 | 17,975 | Joe Mays | Steve Sparks | J.C. Romero | Matt Anderson | | 72 | 70 | 2 |
| 2002-04-16 | vs KCA | 14 | W 8-5 | 9-5 | 2 | 12,013 | Rick Reed | Dan Reichert | Tony Fiore | Blake Stein | Eddie Guardado | 80 | 75 | 5 |
| 2002-04-17 | vs KCA | 15 | L 3-16 | 9-6 | 3 | 13,693 | Brad Radke | Paul Byrd | Paul Byrd | Brad Radke | | 83 | 91 | -8 |
| 2002-04-18 | vs KCA | 16 | W 4-1 | 10-6 | 3 | 13,313 | Eric Milton | Jeff Suppan | Eric Milton | Jeff Suppan | Eddie Guardado | 87 | 92 | -5 |
| 2002-04-19 | vs CLE | 17 | W 12-3 | 11-6 | 2 | 23,491 | Kyle Lohse | CC Sabathia | Kyle Lohse | CC Sabathia | | 99 | 95 | 4 |
| 2002-04-20 | vs CLE | 18 | W 6-2 | 12-6 | 1 | 30,146 | Matt Kinney | Ryan Drese | Matt Kinney | Ryan Drese | | 105 | 97 | 8 |
| 2002-04-21 | vs CLE | 19 | W 4-2 | 13-6 | 1 | 22,264 | Rick Reed | Chuck Finley | Rick Reed | Chuck Finley | Eddie Guardado | 109 | 99 | 10 |
| 2002-04-23 | @ TBA | 20 | L 4-6 | 13-7 | 2 | 10,602 | Brad Radke | Joe Kennedy | Joe Kennedy | Brad Radke | Esteban Yan | 113 | 105 | 8 |
| 2002-04-24 | @ TBA | 21 | L 1-9 | 13-8 | 2 | 10,761 | Eric Milton | Ryan Rupe | Ryan Rupe | Eric Milton | | 114 | 114 | 0 |
| 2002-04-25 | @ TBA | 22 | W 6-2 | 14-8 | 2 | 10,623 | Kyle Lohse | Tanyon Sturtze | Michael Jackson | Esteban Yan | | 120 | 116 | 4 |
| 2002-04-26 | @ DET | 23 | L 2-3 | 14-9 | 2 | 16,394 | Rick Reed | Seth Greisinger | Matt Anderson | Bob Wells | | 122 | 119 | 3 |
| 2002-04-27 | @ DET | 24 | L 1-5 | 14-10 | 2 | 17,030 | Matt Kinney | Nate Cornejo | Nate Cornejo | Matt Kinney | | 123 | 124 | -1 |
| 2002-04-28 | @ DET | 25 | L 4-5 | 14-11 | 2 | 14,108 | Brad Radke | Mark Redman | Julio Santana | Michael Jackson | | 127 | 129 | -2 |
| 2002-04-29 | vs TBA | 26 | W 3-2 | 15-11 | 2 | 11,390 | Eric Milton | Joe Kennedy | Eric Milton | Joe Kennedy | Eddie Guardado | 130 | 131 | -1 |
| 2002-04-30 | vs TBA | 27 | W 6-3 | 16-11 | 2 | 10,205 | Kyle Lohse | Ryan Rupe | Kyle Lohse | Ryan Rupe | Eddie Guardado | 136 | 134 | 2 |
| 2002-05-01 | vs TBA | 28 | W 5-3 | 17-11 | 2 | 12,691 | Rick Reed | Tanyon Sturtze | Rick Reed | Tanyon Sturtze | Eddie Guardado | 141 | 137 | 4 |
| 2002-05-02 | vs TBA | 29 | W 7-6 | 18-11 | 1 | 14,106 | Matt Kinney | Paul Wilson | Tony Fiore | Steven Kent | | 148 | 143 | 5 |
| 2002-05-03 | vs DET | 30 | W 8-4 | 19-11 | 1 | 20,010 | Brad Radke | Nate Cornejo | Brad Radke | Nate Cornejo | | 156 | 147 | 9 |
| 2002-05-04 | vs DET | 31 | W 3-2 | 20-11 | 1 | 21,845 | Eric Milton | Mark Redman | Michael Jackson | Fernando Rodney | | 159 | 149 | 10 |
| 2002-05-05 | vs DET | 32 | L 6-7 | 20-12 | 1 | 16,943 | Kyle Lohse | Jeff Weaver | Jeff Weaver | Kyle Lohse | Juan Acevedo | 165 | 156 | 9 |
| 2002-05-06 | vs DET | 33 | W 3-1 | 21-12 | 1 | 10,708 | Rick Reed | Steve Sparks | Rick Reed | Steve Sparks | Eddie Guardado | 168 | 157 | 11 |
| 2002-05-07 | vs KCA | 34 | L 1-4 | 21-13 | 1 | 12,229 | Matt Kinney | Paul Byrd | Paul Byrd | Matt Kinney | Roberto Hernandez | 169 | 161 | 8 |
| 2002-05-08 | vs KCA | 35 | W 3-1 | 22-13 | 1 | 13,026 | Brad Radke | Jeremy Affeldt | Brad Radke | Jeremy Affeldt | | 172 | 162 | 10 |
| 2002-05-10 | vs NYA | 36 | L 3-5 | 22-14 | 1 | 35,727 | Eric Milton | David Wells | David Wells | Eric Milton | Mariano Rivera | 175 | 167 | 8 |
| 2002-05-11 | vs NYA | 37 | L 2-4 | 22-15 | 1 | 43,465 | Kyle Lohse | Ted Lilly | Mike Stanton | Eddie Guardado | Mariano Rivera | 177 | 171 | 6 |
| 2002-05-12 | vs NYA | 38 | L 4-10 | 22-16 | 1 | 26,165 | Rick Reed | Mike Mussina | Mike Mussina | Rick Reed | | 181 | 181 | 0 |
| 2002-05-13 | @ KCA | 39 | W 3-2 | 23-16 | 1 | 12,389 | Brad Radke | Jeremy Affeldt | J.C. Romero | Jason Grimsley | Eddie Guardado | 184 | 183 | 1 |
| 2002-05-14 | @ KCA | 40 | L 1-8 | 23-17 | 1 | 12,334 | Matt Kinney | Jeff Suppan | Jeff Suppan | Matt Kinney | | 185 | 191 | -6 |
| 2002-05-15 | @ KCA | 41 | W 8-6 | 24-17 | 1 | 12,620 | Eric Milton | Blake Stein | Eric Milton | Dan Reichert | Eddie Guardado | 193 | 197 | -4 |
| 2002-05-16 | @ KCA | 42 | W 14-5 | 25-17 | 1 | 24,055 | Kyle Lohse | Chris George | Kyle Lohse | Chris George | | 207 | 202 | 5 |
| 2002-05-17 | @ NYA | 43 | L 12-13 | 25-18 | 1 | 39,470 | Rick Reed | Mike Mussina | Sterling Hitchcock | Mike Trombley | | 219 | 215 | 4 |
| 2002-05-18 | @ NYA | 44 | L 2-6 | 25-19 | 1 | 46,057 | Tony Fiore | Ted Lilly | Ted Lilly | Tony Fiore | | 221 | 221 | 0 |
| 2002-05-19 | @ NYA | 45 | L 0-3 | 25-20 | 1 | 53,662 | Matt Kinney | Roger Clemens | Roger Clemens | Matt Kinney | Mariano Rivera | 221 | 224 | -3 |
| 2002-05-21 | vs TEX | 46 | W 8-2 | 26-20 | 1 | 16,335 | Eric Milton | Ismael Valdez | Eric Milton | Ismael Valdez | | 229 | 226 | 3 |
| 2002-05-22 | vs TEX | 47 | L 5-6 | 26-21 | 2 | 23,518 | Kyle Lohse | Kenny Rogers | Kenny Rogers | Kyle Lohse | Hideki Irabu | 234 | 232 | 2 |
| 2002-05-24 | @ ANA | 48 | W 5-1 | 27-21 | 2 | 27,494 | Rick Reed | Ramon Ortiz | Rick Reed | Ramon Ortiz | | 239 | 233 | 6 |
| 2002-05-25 | @ ANA | 49 | L 3-4 | 27-22 | 2 | 31,820 | Matt Kinney | Jarrod Washburn | Al Levine | Jack Cressend | | 242 | 237 | 5 |
| 2002-05-26 | @ ANA | 50 | W 5-2 | 28-22 | 2 | 22,854 | Eric Milton | Kevin Appier | Eric Milton | Kevin Appier | Eddie Guardado | 247 | 239 | 8 |
| 2002-05-27 | @ TEX | 51 | W 5-2 | 29-22 | 1 | 30,871 | Kyle Lohse | Kenny Rogers | Kyle Lohse | Kenny Rogers | Eddie Guardado | 252 | 241 | 11 |
| 2002-05-28 | @ TEX | 52 | W 11-4 | 30-22 | 1 | 20,181 | Tony Fiore | Chan Ho Park | Tony Fiore | Chan Ho Park | | 263 | 245 | 18 |
| 2002-05-29 | @ TEX | 53 | L 8-9 | 30-23 | 1 | 23,680 | Rick Reed | Rob Bell | Hideki Irabu | J.C. Romero | | 271 | 254 | 17 |
| 2002-05-30 | vs ANA | 54 | W 7-6 | 31-23 | 1 | 14,521 | Brad Radke | Scott Schoeneweis | Eddie Guardado | Lou Pote | | 278 | 260 | 18 |
| 2002-05-31 | vs ANA | 55 | L 3-11 | 31-24 | 1 | 17,101 | Eric Milton | Jarrod Washburn | Jarrod Washburn | Eric Milton | | 281 | 271 | 10 |
| 2002-06-01 | vs ANA | 56 | W 4-2 | 32-24 | 1 | 17,480 | Kyle Lohse | Kevin Appier | Kyle Lohse | Kevin Appier | Eddie Guardado | 285 | 273 | 12 |
| 2002-06-02 | vs ANA | 57 | L 4-5 | 32-25 | 1 | 18,657 | Matt Kinney | Aaron Sele | Aaron Sele | Matt Kinney | Troy Percival | 289 | 278 | 11 |
| 2002-06-04 | vs CLE | 58 | W 23-2 | 33-25 | 1 | 14,029 | Rick Reed | Ryan Drese | Rick Reed | Ryan Drese | | 312 | 280 | 32 |
| 2002-06-05 | vs CLE | 59 | L 4-6 | 33-26 | 1 | 15,617 | Eric Milton | CC Sabathia | CC Sabathia | Eric Milton | David Riske | 316 | 286 | 30 |
| 2002-06-06 | vs CLE | 60 | W 8-3 | 34-26 | 1 | 15,553 | Kyle Lohse | Bartolo Colon | Kyle Lohse | Bartolo Colon | | 324 | 289 | 35 |
| 2002-06-07 | vs FLO | 61 | W 12-7 | 35-26 | 1 | 20,271 | Johan Santana | Ryan Dempster | Johan Santana | Ryan Dempster | | 336 | 296 | 40 |
| 2002-06-08 | vs FLO | 62 | W 5-3 | 36-26 | 1 | 20,949 | Matt Kinney | Kevin Olsen | Matt Kinney | Kevin Olsen | Eddie Guardado | 341 | 299 | 42 |
| 2002-06-09 | vs FLO | 63 | L 3-6 | 36-27 | 1 | 29,448 | Rick Reed | Julian Tavarez | Julian Tavarez | Rick Reed | Vladimir Nunez | 344 | 305 | 39 |
| 2002-06-10 | vs ATL | 64 | W 6-5 | 37-27 | 1 | 24,534 | Eric Milton | Greg Maddux | Tony Fiore | Kerry Ligtenberg | | 350 | 310 | 40 |
| 2002-06-11 | vs ATL | 65 | L 0-11 | 37-28 | 1 | 23,256 | Kyle Lohse | Tom Glavine | Tom Glavine | Kyle Lohse | | 350 | 321 | 29 |
| 2002-06-12 | vs ATL | 66 | L 2-3 | 37-29 | 1 | 21,485 | Johan Santana | Damian Moss | Damian Moss | Johan Santana | John Smoltz | 352 | 324 | 28 |
| 2002-06-14 | @ MIL | 67 | L 5-7 | 37-30 | 1 | 25,038 | Rick Reed | Glendon Rusch | Ray King | Michael Jackson | Mike DeJean | 357 | 331 | 26 |
| 2002-06-15 | @ MIL | 68 | W 5-2 | 38-30 | 1 | 35,832 | Eric Milton | Jamey Wright | Eric Milton | Jamey Wright | Eddie Guardado | 362 | 333 | 29 |
| 2002-06-16 | @ MIL | 69 | W 7-6 | 39-30 | 1 | 31,218 | Kyle Lohse | Ruben Quevedo | Tony Fiore | Nelson Figueroa | Eddie Guardado | 369 | 339 | 30 |
| 2002-06-18 | @ NYN | 70 | W 6-1 | 40-30 | 1 | 35,947 | Johan Santana | Jeff D'Amico | Johan Santana | Jeff D'Amico | | 375 | 340 | 35 |
| 2002-06-19 | @ NYN | 71 | L 2-4 | 40-31 | 1 | 26,967 | Matt Kinney | Al Leiter | Al Leiter | Matt Kinney | Armando Benitez | 377 | 344 | 33 |
| 2002-06-20 | @ NYN | 72 | L 2-3 | 40-32 | 1 | 23,217 | Eric Milton | Steve Trachsel | Steve Trachsel | Tony Fiore | Armando Benitez | 379 | 347 | 32 |
| 2002-06-21 | @ PHI | 73 | L 0-3 | 40-33 | 1 | 17,039 | Kyle Lohse | Brandon Duckworth | Brandon Duckworth | Kyle Lohse | Jose Mesa | 379 | 350 | 29 |
| 2002-06-22 | @ PHI | 74 | W 4-1 | 41-33 | 1 | 18,759 | Rick Reed | Terry Adams | LaTroy Hawkins | Dan Plesac | Eddie Guardado | 383 | 351 | 32 |
| 2002-06-23 | @ PHI | 75 | W 5-1 | 42-33 | 1 | 38,158 | Johan Santana | Randy Wolf | Tony Fiore | Randy Wolf | | 388 | 352 | 36 |
| 2002-06-24 | vs CHA | 76 | W 5-4 | 43-33 | 1 | 24,102 | Matt Kinney | Jon Garland | LaTroy Hawkins | Bob Howry | Eddie Guardado | 393 | 356 | 37 |
| 2002-06-25 | vs CHA | 77 | L 7-15 | 43-34 | 1 | 24,662 | Eric Milton | Mark Buehrle | Mark Buehrle | Eric Milton | | 400 | 371 | 29 |
| 2002-06-26 | vs CHA | 78 | W 6-5 | 44-34 | 1 | 28,340 | Kyle Lohse | Todd Ritchie | Kyle Lohse | Todd Ritchie | Eddie Guardado | 406 | 376 | 30 |
| 2002-06-27 | vs CHA | 79 | L 4-7 | 44-35 | 1 | 29,532 | Rick Reed | Gary Glover | Gary Glover | Rick Reed | Keith Foulke | 410 | 383 | 27 |
| 2002-06-28 | vs MIL | 80 | W 5-1 | 45-35 | 1 | 25,409 | Johan Santana | Ben Sheets | Johan Santana | Ben Sheets | | 415 | 384 | 31 |
| 2002-06-29 | vs MIL | 81 | L 2-10 | 45-36 | 1 | 30,125 | Matt Kinney | Jose Cabrera | Jose Cabrera | Matt Kinney | | 417 | 394 | 23 |
| 2002-06-30 | vs MIL | 82 | W 4-3 | 46-36 | 1 | 33,193 | Eric Milton | Glendon Rusch | Eric Milton | Glendon Rusch | Eddie Guardado | 421 | 397 | 24 |
| 2002-07-01 | @ OAK | 83 | W 5-4 | 47-36 | 1 | 13,503 | Kyle Lohse | Aaron Harang | J.C. Romero | Mike Venafro | Eddie Guardado | 426 | 401 | 25 |
| 2002-07-02 | @ OAK | 84 | L 3-4 | 47-37 | 1 | 15,317 | Rick Reed | Barry Zito | Chad Bradford | Eddie Guardado | | 429 | 405 | 24 |
| 2002-07-03 | @ OAK | 85 | W 2-1 | 48-37 | 1 | 30,213 | Johan Santana | Mark Mulder | Johan Santana | Mark Mulder | Eddie Guardado | 431 | 406 | 25 |
| 2002-07-04 | @ SEA | 86 | L 1-2 | 48-38 | 1 | 44,543 | Juan Rincon | Freddy Garcia | Arthur Rhodes | Jose Rodriguez | Kazuhiro Sasaki | 432 | 408 | 24 |
| 2002-07-05 | @ SEA | 87 | W 8-4 | 49-38 | 1 | 45,526 | Eric Milton | James Baldwin | Eric Milton | Jeff Nelson | | 440 | 412 | 28 |
| 2002-07-06 | @ SEA | 88 | W 7-2 | 50-38 | 1 | 45,416 | Kyle Lohse | Jamie Moyer | Kyle Lohse | Jamie Moyer | | 447 | 414 | 33 |
| 2002-07-07 | @ SEA | 89 | L 2-8 | 50-39 | 1 | 45,738 | Rick Reed | John Halama | John Halama | Rick Reed | Kazuhiro Sasaki | 449 | 422 | 27 |
| 2002-07-11 | vs TEX | 90 | W 4-3 | 51-39 | 1 | 18,144 | Eric Milton | Chan Ho Park | Eric Milton | Chan Ho Park | Eddie Guardado | 453 | 425 | 28 |
| 2002-07-12 | vs TEX | 91 | W 4-3 | 52-39 | 1 | 25,804 | Rick Reed | Ismael Valdez | Tony Fiore | Hideki Irabu | | 457 | 428 | 29 |
| 2002-07-13 | vs TEX | 92 | L 1-8 | 52-40 | 1 | 28,352 | Juan Rincon | Kenny Rogers | Kenny Rogers | Juan Rincon | | 458 | 436 | 22 |
| 2002-07-14 | vs TEX | 93 | W 5-4 | 53-40 | 1 | 22,610 | Kyle Lohse | Dave Burba | J.C. Romero | Colby Lewis | Eddie Guardado | 463 | 440 | 23 |
| 2002-07-15 | vs ANA | 94 | W 10-8 | 54-40 | 1 | 19,189 | Johan Santana | John Lackey | LaTroy Hawkins | Scott Schoeneweis | Eddie Guardado | 473 | 448 | 25 |
| 2002-07-16 | vs ANA | 95 | L 2-4 | 54-41 | 1 | 26,258 | Eric Milton | Jarrod Washburn | Jarrod Washburn | Eric Milton | Ben Weber | 475 | 452 | 23 |
| 2002-07-17 | @ CLE | 96 | W 8-5 | 55-41 | 1 | 33,324 | Rick Reed | Danys Baez | Rick Reed | Danys Baez | Eddie Guardado | 483 | 457 | 26 |
| 2002-07-18 | @ CLE | 97 | W 8-6 | 56-41 | 1 | 33,573 | Juan Rincon | Ryan Drese | Tony Fiore | Ricardo Rincon | Eddie Guardado | 491 | 463 | 28 |
| 2002-07-19 | @ DET | 98 | W 5-1 | 57-41 | 1 | 23,611 | Kyle Lohse | Brian Moehler | Kyle Lohse | Brian Moehler | Johan Santana | 496 | 464 | 32 |
| 2002-07-20 | @ DET | 99 | W 14-4 | 58-41 | 1 | 22,102 | Joe Mays | Adam Bernero | Joe Mays | Adam Bernero | | 510 | 468 | 42 |
| 2002-07-21 | @ DET | 100 | W 4-2 | 59-41 | 1 | 19,285 | Eric Milton | Steve Sparks | Eric Milton | Steve Sparks | Eddie Guardado | 514 | 470 | 44 |
| 2002-07-22 | @ CHA | 101 | W 11-6 | 60-41 | 1 | 32,352 | Rick Reed | Todd Ritchie | Rick Reed | Todd Ritchie | | 525 | 476 | 49 |
| 2002-07-23 | @ CHA | 102 | L 7-8 | 60-42 | 1 | 22,665 | Johan Santana | Mark Buehrle | Mark Buehrle | Johan Santana | Antonio Osuna | 532 | 484 | 48 |
| 2002-07-24 | @ CHA | 103 | W 8-1 | 61-42 | 1 | 23,535 | Kyle Lohse | Jon Garland | Kyle Lohse | Jon Garland | | 540 | 485 | 55 |
| 2002-07-26 | vs TOR | 104 | W 10-5 | 62-42 | 1 | 25,049 | Joe Mays | Steve Parris | Tony Fiore | Luke Prokopec | | 550 | 490 | 60 |
| 2002-07-27 | vs TOR | 105 | W 5-4 | 63-42 | 1 | 40,306 | Eric Milton | Roy Halladay | Bob Wells | Kelvim Escobar | | 555 | 494 | 61 |
| 2002-07-28 | vs TOR | 106 | W 4-0 | 64-42 | 1 | 30,554 | Johan Santana | Esteban Loaiza | Johan Santana | Esteban Loaiza | | 559 | 494 | 65 |
| 2002-07-30 | vs CHA | 107 | L 0-3 | 64-43 | 1 | 27,391 | Kyle Lohse | Mark Buehrle | Mark Buehrle | Kyle Lohse | | 559 | 497 | 62 |
| 2002-07-31 | vs CHA | 108 | W 2-1 | 65-43 | 1 | 29,478 | Joe Mays | Jon Garland | J.C. Romero | Antonio Osuna | | 561 | 498 | 63 |
| 2002-08-01 | vs CHA | 109 | W 6-0 | 66-43 | 1 | 26,270 | Eric Milton | Dan Wright | Eric Milton | Dan Wright | | 567 | 498 | 69 |
| 2002-08-02 | vs KCA | 110 | W 2-1 | 67-43 | 1 | 23,230 | Rick Reed | Jeff Suppan | Rick Reed | Jeff Suppan | Eddie Guardado | 569 | 499 | 70 |
| 2002-08-03 | vs KCA | 111 | W 4-3 | 68-43 | 1 | 32,567 | Brad Radke | Paul Byrd | Johan Santana | Darrell May | | 573 | 502 | 71 |
| 2002-08-04 | vs KCA | 112 | W 5-4 | 69-43 | 1 | 35,641 | Kyle Lohse | Miguel Asencio | J.C. Romero | Scott Mullen | | 578 | 506 | 72 |
| 2002-08-05 | vs KCA | 113 | L 4-12 | 69-44 | 1 | 27,182 | Joe Mays | Shawn Sedlacek | Shawn Sedlacek | Joe Mays | | 582 | 518 | 64 |
| 2002-08-06 | @ BAL | 114 | L 2-9 | 69-45 | 1 | 33,858 | Eric Milton | Sidney Ponson | Sidney Ponson | Johan Santana | | 584 | 527 | 57 |
| 2002-08-07 | @ BAL | 115 | L 4-6 | 69-46 | 1 | 40,074 | Rick Reed | Scott Erickson | Scott Erickson | Rick Reed | Jorge Julio | 588 | 533 | 55 |
| 2002-08-08 | @ BAL | 116 | L 1-4 | 69-47 | 1 | 36,757 | Brad Radke | Travis Driskill | Travis Driskill | Brad Radke | Jorge Julio | 589 | 537 | 52 |
| 2002-08-09 | @ BOS | 117 | W 5-4 | 70-47 | 1 | 33,973 | Kyle Lohse | Casey Fossum | J.C. Romero | Frank Castillo | Eddie Guardado | 594 | 541 | 53 |
| 2002-08-10 | @ BOS | 118 | L 0-2 | 70-48 | 1 | 32,018 | Joe Mays | Pedro Martinez | Pedro Martinez | Joe Mays | Ugueth Urbina | 594 | 543 | 51 |
| 2002-08-11 | @ BOS | 119 | L 1-3 | 70-49 | 1 | 33,470 | Johan Santana | Tim Wakefield | Tim Wakefield | Johan Santana | Ugueth Urbina | 595 | 546 | 49 |
| 2002-08-13 | vs BAL | 120 | W 6-0 | 71-49 | 1 | 20,268 | Rick Reed | Scott Erickson | Rick Reed | Scott Erickson | | 601 | 546 | 55 |
| 2002-08-14 | vs BAL | 121 | L 5-6 | 71-50 | 1 | 28,488 | Brad Radke | Travis Driskill | Rick Bauer | Tony Fiore | | 606 | 552 | 54 |
| 2002-08-15 | vs BAL | 122 | L 1-3 | 71-51 | 1 | 20,471 | Kyle Lohse | Jason Johnson | Jason Johnson | Kyle Lohse | Jorge Julio | 607 | 555 | 52 |
| 2002-08-16 | vs BOS | 123 | W 5-0 | 72-51 | 1 | 35,824 | Joe Mays | Pedro Martinez | Joe Mays | Pedro Martinez | | 612 | 555 | 57 |
| 2002-08-17 | vs BOS | 124 | L 2-5 | 72-52 | 1 | 43,345 | Johan Santana | Tim Wakefield | Tim Wakefield | Johan Santana | | 614 | 560 | 54 |
| 2002-08-18 | vs BOS | 125 | W 6-2 | 73-52 | 1 | 37,196 | Rick Reed | John Burkett | Rick Reed | John Burkett | | 620 | 562 | 58 |
| 2002-08-19 | @ CHA | 126 | W 7-3 | 74-52 | 1 | 24,016 | Brad Radke | Gary Glover | Brad Radke | Gary Glover | | 627 | 565 | 62 |
| 2002-08-20 | @ CHA | 127 | W 5-0 | 75-52 | 1 | 16,192 | Kyle Lohse | Jim Parque | Kyle Lohse | Jim Parque | | 632 | 565 | 67 |
| 2002-08-21 | @ CHA | 128 | L 1-10 | 75-53 | 1 | 17,225 | Joe Mays | Mark Buehrle | Mark Buehrle | Joe Mays | | 633 | 575 | 58 |
| 2002-08-22 | @ KCA | 129 | W 8-6 | 76-53 | 1 | 11,785 | Johan Santana | Runelvys Hernandez | Johan Santana | Runelvys Hernandez | Eddie Guardado | 641 | 581 | 60 |
| 2002-08-23 | @ KCA | 130 | W 9-2 | 77-53 | 1 | 29,685 | Rick Reed | Jeff Suppan | Rick Reed | Jeff Suppan | | 650 | 583 | 67 |
| 2002-08-24 | @ KCA | 131 | W 6-5 | 78-53 | 1 | 22,180 | Brad Radke | Paul Byrd | Brad Radke | Paul Byrd | Eddie Guardado | 656 | 588 | 68 |
| 2002-08-25 | @ KCA | 132 | L 2-4 | 78-54 | 1 | 13,440 | Kyle Lohse | Miguel Asencio | Miguel Asencio | Kyle Lohse | Roberto Hernandez | 658 | 592 | 66 |
| 2002-08-27 | vs SEA | 133 | W 5-2 | 79-54 | 1 | 28,660 | Joe Mays | Ismael Valdez | Joe Mays | Ismael Valdez | Eddie Guardado | 663 | 594 | 69 |
| 2002-08-28 | vs SEA | 134 | W 2-1 | 80-54 | 1 | 31,414 | Johan Santana | Joel Pineiro | Johan Santana | Joel Pineiro | Eddie Guardado | 665 | 595 | 70 |
| 2002-08-29 | vs SEA | 135 | L 0-2 | 80-55 | 1 | 29,325 | Rick Reed | Jamie Moyer | Jamie Moyer | Rick Reed | Kazuhiro Sasaki | 665 | 597 | 68 |
| 2002-08-30 | @ OAK | 136 | L 2-4 | 80-56 | 1 | 25,221 | Brad Radke | Tim Hudson | Tim Hudson | Brad Radke | Billy Koch | 667 | 601 | 66 |
| 2002-08-31 | @ OAK | 137 | L 3-6 | 80-57 | 1 | 42,841 | Kyle Lohse | Cory Lidle | Jim Mecir | J.C. Romero | Billy Koch | 670 | 607 | 63 |
| 2002-09-01 | @ OAK | 138 | L 5-7 | 80-58 | 1 | 37,676 | Joe Mays | Mark Mulder | Billy Koch | Eddie Guardado | | 675 | 614 | 61 |
| 2002-09-02 | @ SEA | 139 | L 2-5 | 80-59 | 1 | 41,050 | Eric Milton | Joel Pineiro | Arthur Rhodes | Johan Santana | Kazuhiro Sasaki | 677 | 619 | 58 |
| 2002-09-04 | @ SEA | 140 | W 3-2 | 81-59 | 1 | 44,580 | Rick Reed | Jamie Moyer | Rick Reed | Jamie Moyer | Eddie Guardado | 680 | 621 | 59 |
| 2002-09-06 | vs OAK | 141 | W 6-0 | 82-59 | 1 | 27,409 | Brad Radke | Cory Lidle | Brad Radke | Cory Lidle | | 686 | 621 | 65 |
| 2002-09-07 | vs OAK | 142 | L 0-2 | 82-60 | 1 | 43,628 | Joe Mays | Mark Mulder | Mark Mulder | Joe Mays | Billy Koch | 686 | 623 | 63 |
| 2002-09-08 | vs OAK | 143 | L 0-6 | 82-61 | 1 | 20,102 | Eric Milton | Barry Zito | Barry Zito | Eric Milton | | 686 | 629 | 57 |
| 2002-09-09 | vs DET | 144 | W 5-2 | 83-61 | 1 | 11,684 | Rick Reed | Mike Maroth | Rick Reed | Mike Maroth | Eddie Guardado | 691 | 631 | 60 |
| 2002-09-10 | vs DET | 145 | W 11-4 | 84-61 | 1 | 12,408 | Kyle Lohse | Shane Loux | Kyle Lohse | Shane Loux | | 702 | 635 | 67 |
| 2002-09-11 | vs DET | 146 | W 8-2 | 85-61 | 1 | 13,106 | Brad Radke | Mark Redman | Brad Radke | Mark Redman | | 710 | 637 | 73 |
| 2002-09-12 | @ CLE | 147 | L 4-5 | 85-62 | 1 | 28,649 | Joe Mays | CC Sabathia | Jerrod Riggan | Joe Mays | Danys Baez | 714 | 642 | 72 |
| 2002-09-13 | @ CLE | 148 | L 5-12 | 85-63 | 1 | 30,421 | Eric Milton | Terry Mulholland | Terry Mulholland | Eric Milton | | 719 | 654 | 65 |
| 2002-09-14 | @ CLE | 149 | W 3-2 | 86-63 | 1 | 32,330 | Rick Reed | Jason Davis | Rick Reed | Carl Sadler | Eddie Guardado | 722 | 656 | 66 |
| 2002-09-15 | @ CLE | 150 | W 5-0 | 87-63 | 1 | 28,061 | Kyle Lohse | Cliff Lee | Kyle Lohse | Cliff Lee | | 727 | 656 | 71 |
| 2002-09-17 | @ DET | 151 | W 7-4 | 88-63 | 1 | 12,833 | Brad Radke | Shane Loux | Brad Radke | Shane Loux | Eddie Guardado | 734 | 660 | 74 |
| 2002-09-18 | @ DET | 152 | W 2-0 | 89-63 | 1 | 11,214 | Joe Mays | Steve Sparks | Joe Mays | Steve Sparks | Eddie Guardado | 736 | 660 | 76 |
| 2002-09-20 | @ CHA | 153 | L 2-10 | 89-64 | 1 | 16,128 | Rick Reed | Dan Wright | Dan Wright | Juan Rincon | | 738 | 670 | 68 |
| 2002-09-21 | @ CHA | 154 | L 4-14 | 89-65 | 1 | 20,645 | Brad Radke | Jon Rauch | Jon Rauch | Brad Radke | | 742 | 684 | 58 |
| 2002-09-22 | @ CHA | 155 | L 2-8 | 89-66 | 1 | 15,112 | Joe Mays | Mark Buehrle | Mark Buehrle | Joe Mays | | 744 | 692 | 52 |
| 2002-09-24 | vs CLE | 156 | W 4-3 | 90-66 | 1 | 21,634 | Eric Milton | Ricardo Rodriguez | LaTroy Hawkins | Dave Elder | | 748 | 695 | 53 |
| 2002-09-25 | vs CLE | 157 | W 7-5 | 91-66 | 1 | 15,314 | Rick Reed | Brian Tallet | J.C. Romero | Dave Maurer | | 755 | 700 | 55 |
| 2002-09-26 | vs CLE | 158 | L 4-8 | 91-67 | 1 | 17,772 | Brad Radke | Ryan Drese | Ryan Drese | Michael Jackson | | 759 | 708 | 51 |
| 2002-09-27 | vs CHA | 159 | W 3-1 | 92-67 | 1 | 21,905 | Joe Mays | Jon Rauch | Tony Fiore | Gary Glover | Eddie Guardado | 762 | 709 | 53 |
| 2002-09-28 | vs CHA | 160 | W 3-2 | 93-67 | 1 | 32,072 | Kyle Lohse | Mark Buehrle | LaTroy Hawkins | Mark Buehrle | Eddie Guardado | 765 | 711 | 54 |
| 2002-09-29 | vs CHA | 161 | W 3-1 | 94-67 | 1 | 31,270 | Eric Milton | Jon Garland | Bob Wells | Mike Porzio | J.C. Romero | 768 | 712 | 56 |