| 2002-04-01 | vs MIN | 1 | L 6-8 | 0-1 | 5 | 40,605 | Jeff Suppan | Brad Radke | J.C. Romero | Cory Bailey | Eddie Guardado | 6 | 8 | -2 |
| 2002-04-03 | vs MIN | 2 | L 0-1 | 0-2 | 5 | 10,856 | Dan Reichert | Eric Milton | Eric Milton | Dan Reichert | Eddie Guardado | 6 | 9 | -3 |
| 2002-04-05 | vs CHA | 3 | W 5-2 | 1-2 | 3 | 15,975 | Paul Byrd | Jon Garland | Paul Byrd | Jon Garland | Blake Stein | 11 | 11 | 0 |
| 2002-04-06 | vs CHA | 4 | L 0-14 | 1-3 | 4 | 15,178 | Chad Durbin | Mark Buehrle | Mark Buehrle | Chad Durbin | | 11 | 25 | -14 |
| 2002-04-07 | vs CHA | 5 | W 9-2 | 2-3 | 3 | 10,788 | Jeff Suppan | Todd Ritchie | Jeff Suppan | Todd Ritchie | | 20 | 27 | -7 |
| 2002-04-09 | @ BOS | 6 | L 4-8 | 2-4 | 4 | 31,115 | Dan Reichert | Tim Wakefield | Tim Wakefield | Dan Reichert | | 24 | 35 | -11 |
| 2002-04-10 | @ BOS | 7 | W 6-2 | 3-4 | 4 | 33,376 | Paul Byrd | Derek Lowe | Paul Byrd | Derek Lowe | Cory Bailey | 30 | 37 | -7 |
| 2002-04-11 | @ BOS | 8 | W 8-5 | 4-4 | 3 | 32,953 | Chad Durbin | Frank Castillo | Jason Grimsley | Ugueth Urbina | | 38 | 42 | -4 |
| 2002-04-12 | @ CLE | 9 | L 1-3 | 4-5 | 4 | 29,970 | Jeff Suppan | CC Sabathia | CC Sabathia | Jeff Suppan | Bob Wickman | 39 | 45 | -6 |
| 2002-04-13 | @ CLE | 10 | L 7-8 | 4-6 | 4 | 28,455 | Darrell May | Ryan Drese | Paul Shuey | Cory Bailey | | 46 | 53 | -7 |
| 2002-04-16 | @ MIN | 11 | L 5-8 | 4-7 | 4 | 12,013 | Dan Reichert | Rick Reed | Tony Fiore | Blake Stein | Eddie Guardado | 51 | 61 | -10 |
| 2002-04-17 | @ MIN | 12 | W 16-3 | 5-7 | 4 | 13,693 | Paul Byrd | Brad Radke | Paul Byrd | Brad Radke | | 67 | 64 | 3 |
| 2002-04-18 | @ MIN | 13 | L 1-4 | 5-8 | 4 | 13,313 | Jeff Suppan | Eric Milton | Eric Milton | Jeff Suppan | Eddie Guardado | 68 | 68 | 0 |
| 2002-04-19 | vs BOS | 14 | L 0-4 | 5-9 | 4 | 24,456 | Chris George | Pedro Martinez | Pedro Martinez | Chris George | | 68 | 72 | -4 |
| 2002-04-21 | vs BOS | 15 | L 2-12 | 5-11 | 4 | 0 | Dan Reichert | John Burkett | John Burkett | Dan Reichert | Tim Wakefield | 70 | 84 | -14 |
| 2002-04-21 | vs BOS | 16 | L 7-8 | 5-11 | 4 | 17,289 | Bryan Rekar | Derek Lowe | Derek Lowe | Bryan Rekar | Ugueth Urbina | 77 | 92 | -15 |
| 2002-04-22 | vs DET | 17 | W 6-0 | 6-11 | 4 | 10,470 | Paul Byrd | Mark Redman | Paul Byrd | Mark Redman | | 83 | 92 | -9 |
| 2002-04-23 | vs DET | 18 | L 0-3 | 6-12 | 4 | 11,125 | Jeff Suppan | Jeff Weaver | Jeff Weaver | Jeff Suppan | | 83 | 95 | -12 |
| 2002-04-24 | vs DET | 19 | W 8-2 | 7-12 | 4 | 11,825 | Chris George | Steve Sparks | Jeremy Affeldt | Steve Sparks | | 91 | 97 | -6 |
| 2002-04-26 | vs BAL | 20 | L 5-10 | 7-13 | 4 | 12,372 | Dan Reichert | Sean Douglass | Buddy Groom | Jason Grimsley | | 96 | 107 | -11 |
| 2002-04-27 | vs BAL | 21 | L 4-9 | 7-14 | 4 | 16,850 | Paul Byrd | Sidney Ponson | Sidney Ponson | Paul Byrd | | 100 | 116 | -16 |
| 2002-04-28 | vs BAL | 22 | L 0-13 | 7-15 | 4 | 15,643 | Bryan Rekar | Scott Erickson | Scott Erickson | Bryan Rekar | | 100 | 129 | -29 |
| 2002-04-29 | @ DET | 23 | W 4-0 | 8-15 | 4 | 9,643 | Jeff Suppan | Jeff Weaver | Jeff Suppan | Jeff Weaver | | 104 | 129 | -25 |
| 2002-04-30 | @ DET | 24 | L 3-9 | 8-16 | 4 | 14,421 | Chris George | Steve Sparks | Steve Sparks | Chris George | | 107 | 138 | -31 |
| 2002-05-01 | @ DET | 25 | L 6-7 | 8-17 | 5 | 24,481 | Dan Reichert | Seth Greisinger | Jamie Walker | Cory Bailey | Juan Acevedo | 113 | 145 | -32 |
| 2002-05-02 | @ BAL | 26 | L 2-6 | 8-18 | 5 | 25,748 | Paul Byrd | Sidney Ponson | Sidney Ponson | Paul Byrd | Rick Bauer | 115 | 151 | -36 |
| 2002-05-03 | @ BAL | 27 | L 3-4 | 8-19 | 5 | 31,792 | Jeremy Affeldt | Scott Erickson | Willis Roberts | Cory Bailey | Jorge Julio | 118 | 155 | -37 |
| 2002-05-04 | @ BAL | 28 | L 0-10 | 8-20 | 5 | 42,131 | Jeff Suppan | Rodrigo Lopez | Rodrigo Lopez | Jeff Suppan | | 118 | 165 | -47 |
| 2002-05-05 | @ BAL | 29 | L 2-3 | 8-21 | 5 | 39,348 | Chris George | Calvin Maduro | Calvin Maduro | Chris George | Jorge Julio | 120 | 168 | -48 |
| 2002-05-07 | @ MIN | 30 | W 4-1 | 9-21 | 5 | 12,229 | Paul Byrd | Matt Kinney | Paul Byrd | Matt Kinney | Roberto Hernandez | 124 | 169 | -45 |
| 2002-05-08 | @ MIN | 31 | L 1-3 | 9-22 | 5 | 13,026 | Jeremy Affeldt | Brad Radke | Brad Radke | Jeremy Affeldt | | 125 | 172 | -47 |
| 2002-05-09 | vs CLE | 32 | W 5-3 | 10-22 | 5 | 12,555 | Jeff Suppan | Bartolo Colon | Jeff Suppan | Ricardo Rincon | Roberto Hernandez | 130 | 175 | -45 |
| 2002-05-10 | vs CLE | 33 | W 9-0 | 11-22 | 4 | 24,279 | Chris George | CC Sabathia | Dan Reichert | CC Sabathia | | 139 | 175 | -36 |
| 2002-05-12 | vs CLE | 34 | W 4-1 | 12-22 | 4 | 10,820 | Paul Byrd | Chuck Finley | Paul Byrd | Chuck Finley | Roberto Hernandez | 143 | 176 | -33 |
| 2002-05-13 | vs MIN | 35 | L 2-3 | 12-23 | 4 | 12,389 | Jeremy Affeldt | Brad Radke | J.C. Romero | Jason Grimsley | Eddie Guardado | 145 | 179 | -34 |
| 2002-05-14 | vs MIN | 36 | W 8-1 | 13-23 | 4 | 12,334 | Jeff Suppan | Matt Kinney | Jeff Suppan | Matt Kinney | | 153 | 180 | -27 |
| 2002-05-15 | vs MIN | 37 | L 6-8 | 13-24 | 4 | 12,620 | Blake Stein | Eric Milton | Eric Milton | Dan Reichert | Eddie Guardado | 159 | 188 | -29 |
| 2002-05-16 | vs MIN | 38 | L 5-14 | 13-25 | 4 | 24,055 | Chris George | Kyle Lohse | Kyle Lohse | Chris George | | 164 | 202 | -38 |
| 2002-05-17 | @ CLE | 39 | W 6-2 | 14-25 | 4 | 32,593 | Paul Byrd | Chuck Finley | Paul Byrd | Chuck Finley | | 170 | 204 | -34 |
| 2002-05-18 | @ CLE | 40 | W 4-2 | 15-26 | 4 | 29,388 | Jeremy Affeldt | CC Sabathia | Dan Reichert | Bob Wickman | Roberto Hernandez | 174 | 206 | -32 |
| 2002-05-18 | @ CLE | 41 | L 1-4 | 15-26 | 4 | 32,110 | Darrell May | Ryan Drese | Ryan Drese | Darrell May | Bob Wickman | 175 | 210 | -35 |
| 2002-05-19 | @ CLE | 42 | W 5-4 | 15-27 | 4 | 31,105 | Jeff Suppan | Danys Baez | Jason Grimsley | Bob Wickman | Roberto Hernandez | 180 | 214 | -34 |
| 2002-05-20 | @ ANA | 43 | L 3-6 | 15-28 | 5 | 14,035 | Blake Stein | Kevin Appier | Kevin Appier | Blake Stein | Troy Percival | 183 | 220 | -37 |
| 2002-05-21 | @ ANA | 44 | L 1-5 | 15-29 | 5 | 15,593 | Miguel Asencio | Aaron Sele | Dennis Cook | Dan Reichert | | 184 | 225 | -41 |
| 2002-05-22 | @ ANA | 45 | L 6-7 | 15-30 | 5 | 16,163 | Paul Byrd | Scott Schoeneweis | Ben Weber | Darrell May | Troy Percival | 190 | 232 | -42 |
| 2002-05-25 | vs TEX | 46 | W 6-3 | 16-30 | 5 | 20,062 | Jeff Suppan | Dave Burba | Jeff Suppan | Dave Burba | Roberto Hernandez | 196 | 235 | -39 |
| 2002-05-26 | vs TEX | 47 | W 7-5 | 18-30 | 5 | 0 | Miguel Asencio | Ismael Valdez | Cory Bailey | Hideki Irabu | | 203 | 240 | -37 |
| 2002-05-26 | vs TEX | 48 | W 9-8 | 18-30 | 5 | 21,740 | Darrell May | Doug Davis | Cory Bailey | Chris Michalak | Roberto Hernandez | 212 | 248 | -36 |
| 2002-05-28 | vs ANA | 49 | W 7-4 | 19-30 | 5 | 11,773 | Paul Byrd | Aaron Sele | Paul Byrd | Aaron Sele | Roberto Hernandez | 219 | 252 | -33 |
| 2002-05-29 | vs ANA | 50 | L 2-12 | 19-31 | 5 | 13,662 | Jeremy Affeldt | Ramon Ortiz | Ramon Ortiz | Jeremy Affeldt | | 221 | 264 | -43 |
| 2002-05-31 | @ TEX | 51 | W 10-7 | 20-31 | 4 | 30,700 | Jeff Suppan | Ismael Valdez | Cory Bailey | Hideki Irabu | | 231 | 271 | -40 |
| 2002-06-01 | @ TEX | 52 | L 1-3 | 20-32 | 4 | 39,245 | Darrell May | Kenny Rogers | Kenny Rogers | Darrell May | | 232 | 274 | -42 |
| 2002-06-02 | @ TEX | 53 | L 6-8 | 20-33 | 4 | 26,464 | Paul Byrd | Chan Ho Park | Chan Ho Park | Paul Byrd | Hideki Irabu | 238 | 282 | -44 |
| 2002-06-03 | @ CHA | 54 | L 0-4 | 20-34 | 5 | 15,168 | Jeremy Affeldt | Jon Garland | Jon Garland | Jeremy Affeldt | | 238 | 286 | -48 |
| 2002-06-04 | @ CHA | 55 | W 3-2 | 21-34 | 4 | 13,063 | Miguel Asencio | Mark Buehrle | Miguel Asencio | Mark Buehrle | Roberto Hernandez | 241 | 288 | -47 |
| 2002-06-05 | @ CHA | 56 | L 1-6 | 21-35 | 4 | 12,167 | Jeff Suppan | Gary Glover | Gary Glover | Jeff Suppan | | 242 | 294 | -52 |
| 2002-06-06 | @ CHA | 57 | W 4-3 | 22-35 | 4 | 14,311 | Darrell May | Todd Ritchie | Darrell May | Todd Ritchie | Roberto Hernandez | 246 | 297 | -51 |
| 2002-06-07 | vs SLN | 58 | L 6-12 | 22-36 | 4 | 34,194 | Paul Byrd | Darryl Kile | Darryl Kile | Paul Byrd | | 252 | 309 | -57 |
| 2002-06-08 | vs SLN | 59 | L 3-11 | 22-37 | 4 | 40,016 | Jeremy Affeldt | Matt Morris | Matt Morris | Jeremy Affeldt | | 255 | 320 | -65 |
| 2002-06-09 | vs SLN | 60 | W 3-2 | 23-37 | 4 | 26,905 | Miguel Asencio | Jason Simontacchi | Roberto Hernandez | Mike Timlin | | 258 | 322 | -64 |
| 2002-06-10 | vs FLO | 61 | L 8-15 | 23-38 | 4 | 13,493 | Jeff Suppan | A.J. Burnett | Armando Almanza | Mac Suzuki | | 266 | 337 | -71 |
| 2002-06-11 | vs FLO | 62 | W 6-0 | 24-38 | 4 | 12,963 | Darrell May | Michael Tejera | Darrell May | Michael Tejera | | 272 | 337 | -65 |
| 2002-06-12 | vs FLO | 63 | L 5-13 | 24-39 | 4 | 14,027 | Paul Byrd | Ryan Dempster | Ryan Dempster | Paul Byrd | | 277 | 350 | -73 |
| 2002-06-14 | @ SLN | 64 | L 0-3 | 24-40 | 4 | 40,510 | Miguel Asencio | Matt Morris | Matt Morris | Miguel Asencio | Steve Kline | 277 | 353 | -76 |
| 2002-06-15 | @ SLN | 65 | L 3-5 | 24-41 | 4 | 47,453 | Jeff Suppan | Jason Simontacchi | Jason Simontacchi | Jeff Suppan | Dave Veres | 280 | 358 | -78 |
| 2002-06-16 | @ SLN | 66 | L 1-5 | 24-42 | 4 | 47,522 | Darrell May | Woody Williams | Woody Williams | Darrell May | | 281 | 363 | -82 |
| 2002-06-18 | @ MON | 67 | L 4-5 | 24-43 | 5 | 6,249 | Shawn Sedlacek | Tony Armas | Zach Day | Scott Mullen | Scott Stewart | 285 | 368 | -83 |
| 2002-06-19 | @ MON | 68 | L 3-6 | 24-44 | 5 | 6,187 | Mac Suzuki | Tomo Ohka | Tomo Ohka | Mac Suzuki | Scott Stewart | 288 | 374 | -86 |
| 2002-06-20 | @ MON | 69 | L 4-5 | 24-45 | 5 | 5,773 | Jeff Suppan | Masato Yoshii | Joey Eischen | Scott Mullen | | 292 | 379 | -87 |
| 2002-06-21 | @ NYN | 70 | L 3-4 | 24-46 | 5 | 37,547 | Darrell May | Shawn Estes | Mark Guthrie | Brad Voyles | | 295 | 383 | -88 |
| 2002-06-22 | @ NYN | 71 | W 5-1 | 25-46 | 4 | 44,790 | Paul Byrd | Pedro Astacio | Paul Byrd | Pedro Astacio | | 300 | 384 | -84 |
| 2002-06-23 | @ NYN | 72 | L 4-5 | 25-47 | 5 | 41,406 | Shawn Sedlacek | Jeff D'Amico | Scott Strickland | Jason Grimsley | Armando Benitez | 304 | 389 | -85 |
| 2002-06-25 | vs DET | 73 | W 8-6 | 26-47 | 4 | 12,952 | Jeff Suppan | Mike Maroth | Jeff Suppan | Julio Santana | Roberto Hernandez | 312 | 395 | -83 |
| 2002-06-26 | vs DET | 74 | W 6-5 | 27-47 | 4 | 12,828 | Darrell May | Adam Bernero | Dan Reichert | Adam Bernero | Roberto Hernandez | 318 | 400 | -82 |
| 2002-06-27 | vs DET | 75 | W 5-2 | 28-47 | 4 | 16,373 | Paul Byrd | Steve Sparks | Paul Byrd | Steve Sparks | Roberto Hernandez | 323 | 402 | -79 |
| 2002-06-28 | vs SDN | 76 | W 14-10 | 29-47 | 4 | 29,935 | Miguel Asencio | Brian Lawrence | Jason Grimsley | Eric Cyr | | 337 | 412 | -75 |
| 2002-06-29 | vs SDN | 77 | L 4-8 | 29-48 | 4 | 27,441 | Shawn Sedlacek | Brett Tomko | Steve Reed | Jason Grimsley | | 341 | 420 | -79 |
| 2002-06-30 | vs SDN | 78 | W 13-1 | 30-48 | 4 | 22,073 | Jeff Suppan | Jake Peavy | Jeff Suppan | Jake Peavy | | 354 | 421 | -67 |
| 2002-07-01 | @ SEA | 79 | L 0-7 | 30-49 | 4 | 43,577 | Darrell May | Jamie Moyer | Jamie Moyer | Darrell May | | 354 | 428 | -74 |
| 2002-07-02 | @ SEA | 80 | W 7-5 | 31-49 | 4 | 45,652 | Paul Byrd | Rafael Soriano | Paul Byrd | Kazuhiro Sasaki | Roberto Hernandez | 361 | 433 | -72 |
| 2002-07-03 | @ SEA | 81 | L 0-3 | 31-50 | 4 | 44,340 | Miguel Asencio | Joel Pineiro | Joel Pineiro | Miguel Asencio | Kazuhiro Sasaki | 361 | 436 | -75 |
| 2002-07-04 | @ OAK | 82 | L 2-3 | 31-51 | 4 | 28,315 | Shawn Sedlacek | Cory Lidle | Billy Koch | Roberto Hernandez | | 363 | 439 | -76 |
| 2002-07-05 | @ OAK | 83 | L 3-4 | 31-52 | 4 | 53,802 | Jeff Suppan | Tim Hudson | Jim Mecir | Roberto Hernandez | | 366 | 443 | -77 |
| 2002-07-06 | @ OAK | 84 | W 4-3 | 32-52 | 4 | 18,259 | Darrell May | Aaron Harang | Scott Mullen | Billy Koch | Brad Voyles | 370 | 446 | -76 |
| 2002-07-07 | @ OAK | 85 | L 2-3 | 32-53 | 4 | 31,676 | Paul Byrd | Barry Zito | Barry Zito | Paul Byrd | Billy Koch | 372 | 449 | -77 |
| 2002-07-11 | vs ANA | 86 | L 0-1 | 32-54 | 4 | 13,031 | Darrell May | Jarrod Washburn | Jarrod Washburn | Darrell May | Troy Percival | 372 | 450 | -78 |
| 2002-07-12 | vs ANA | 87 | L 3-11 | 32-55 | 5 | 24,824 | Jeff Suppan | Kevin Appier | Kevin Appier | Jeff Suppan | | 375 | 461 | -86 |
| 2002-07-13 | vs ANA | 88 | W 4-0 | 33-55 | 5 | 19,504 | Paul Byrd | Aaron Sele | Paul Byrd | Aaron Sele | | 379 | 461 | -82 |
| 2002-07-14 | vs ANA | 89 | W 12-3 | 34-55 | 4 | 12,457 | Miguel Asencio | Ramon Ortiz | Miguel Asencio | Ramon Ortiz | | 391 | 464 | -73 |
| 2002-07-15 | vs TEX | 90 | W 8-6 | 36-55 | 4 | 0 | Shawn Sedlacek | Joaquin Benoit | Shawn Sedlacek | Joaquin Benoit | Roberto Hernandez | 399 | 470 | -71 |
| 2002-07-15 | vs TEX | 91 | W 6-4 | 36-55 | 4 | 14,905 | Runelvys Hernandez | Rob Bell | Kris Wilson | Anthony Telford | Roberto Hernandez | 405 | 474 | -69 |
| 2002-07-16 | vs TEX | 92 | W 6-5 | 37-55 | 4 | 14,677 | Darrell May | Chan Ho Park | Kris Wilson | Juan Alvarez | | 411 | 479 | -68 |
| 2002-07-17 | vs CHA | 93 | W 8-6 | 38-55 | 4 | 13,823 | Jeff Suppan | Todd Ritchie | Jeff Suppan | Todd Ritchie | Roberto Hernandez | 419 | 485 | -66 |
| 2002-07-18 | vs CHA | 94 | W 5-3 | 39-55 | 4 | 15,522 | Paul Byrd | Mark Buehrle | Paul Byrd | Damaso Marte | | 424 | 488 | -64 |
| 2002-07-19 | vs CLE | 95 | W 8-5 | 40-55 | 4 | 20,922 | Miguel Asencio | Jason Phillips | Scott Mullen | Heath Murray | Roberto Hernandez | 432 | 493 | -61 |
| 2002-07-20 | vs CLE | 96 | W 7-5 | 41-56 | 4 | 0 | Runelvys Hernandez | Jaret Wright | Runelvys Hernandez | Jaret Wright | Roberto Hernandez | 439 | 498 | -59 |
| 2002-07-20 | vs CLE | 97 | L 3-5 | 41-56 | 4 | 36,277 | Shawn Sedlacek | Charles Nagy | Paul Shuey | Brad Voyles | Bob Wickman | 442 | 503 | -61 |
| 2002-07-21 | vs CLE | 98 | W 13-12 | 42-56 | 4 | 15,637 | Darrell May | CC Sabathia | Scott Mullen | Heath Murray | | 455 | 515 | -60 |
| 2002-07-23 | @ DET | 99 | L 1-10 | 42-57 | 4 | 14,470 | Jeff Suppan | Mark Redman | Mark Redman | Jeff Suppan | | 456 | 525 | -69 |
| 2002-07-24 | @ DET | 100 | L 0-3 | 42-58 | 4 | 18,848 | Paul Byrd | Jose Lima | Jose Lima | Paul Byrd | Juan Acevedo | 456 | 528 | -72 |
| 2002-07-25 | @ DET | 101 | L 2-5 | 42-59 | 4 | 19,540 | Miguel Asencio | Mike Maroth | Mike Maroth | Miguel Asencio | Juan Acevedo | 458 | 533 | -75 |
| 2002-07-26 | @ CHA | 102 | L 2-10 | 42-60 | 4 | 20,803 | Shawn Sedlacek | Dan Wright | Dan Wright | Shawn Sedlacek | | 460 | 543 | -83 |
| 2002-07-27 | @ CHA | 103 | L 1-9 | 42-61 | 4 | 28,931 | Darrell May | Gary Glover | Gary Glover | Darrell May | | 461 | 552 | -91 |
| 2002-07-28 | @ CHA | 104 | L 2-4 | 42-62 | 4 | 29,534 | Jeff Suppan | Rocky Biddle | Bob Howry | Jeff Suppan | Damaso Marte | 463 | 556 | -93 |
| 2002-07-29 | vs TOR | 105 | W 4-1 | 43-62 | 4 | 14,759 | Paul Byrd | Chris Carpenter | Paul Byrd | Chris Carpenter | | 467 | 557 | -90 |
| 2002-07-30 | vs TOR | 106 | L 4-13 | 43-63 | 4 | 13,066 | Miguel Asencio | Pete Walker | Pete Walker | Miguel Asencio | | 471 | 570 | -99 |
| 2002-07-31 | vs TOR | 107 | L 2-9 | 43-64 | 4 | 13,461 | Shawn Sedlacek | Steve Parris | Steve Parris | Shawn Sedlacek | | 473 | 579 | -106 |
| 2002-08-01 | vs TOR | 108 | L 2-3 | 43-65 | 4 | 12,669 | Runelvys Hernandez | Roy Halladay | Roy Halladay | Runelvys Hernandez | Kelvim Escobar | 475 | 582 | -107 |
| 2002-08-02 | @ MIN | 109 | L 1-2 | 43-66 | 4 | 23,230 | Jeff Suppan | Rick Reed | Rick Reed | Jeff Suppan | Eddie Guardado | 476 | 584 | -108 |
| 2002-08-03 | @ MIN | 110 | L 3-4 | 43-67 | 4 | 32,567 | Paul Byrd | Brad Radke | Johan Santana | Darrell May | | 479 | 588 | -109 |
| 2002-08-04 | @ MIN | 111 | L 4-5 | 43-68 | 4 | 35,641 | Miguel Asencio | Kyle Lohse | J.C. Romero | Scott Mullen | | 483 | 593 | -110 |
| 2002-08-05 | @ MIN | 112 | W 12-4 | 44-68 | 4 | 27,182 | Shawn Sedlacek | Joe Mays | Shawn Sedlacek | Joe Mays | | 495 | 597 | -102 |
| 2002-08-06 | @ NYA | 113 | W 6-2 | 45-68 | 4 | 48,275 | Runelvys Hernandez | Mike Mussina | Runelvys Hernandez | Mike Mussina | | 501 | 599 | -98 |
| 2002-08-07 | @ NYA | 114 | L 2-6 | 45-69 | 4 | 40,184 | Jeff Suppan | Roger Clemens | Roger Clemens | Jeff Suppan | | 503 | 605 | -102 |
| 2002-08-08 | @ NYA | 115 | L 3-6 | 45-70 | 4 | 55,142 | Paul Byrd | Andy Pettitte | Andy Pettitte | Paul Byrd | Mariano Rivera | 506 | 611 | -105 |
| 2002-08-09 | vs TBA | 116 | W 5-4 | 46-70 | 4 | 23,003 | Miguel Asencio | Joe Kennedy | Darrell May | Travis Phelps | | 511 | 615 | -104 |
| 2002-08-10 | vs TBA | 117 | L 6-13 | 46-71 | 4 | 18,213 | Shawn Sedlacek | Victor Zambrano | Victor Zambrano | Shawn Sedlacek | Wilson Alvarez | 517 | 628 | -111 |
| 2002-08-11 | vs TBA | 118 | W 10-0 | 47-71 | 4 | 15,527 | Runelvys Hernandez | Jorge Sosa | Runelvys Hernandez | Jorge Sosa | | 527 | 628 | -101 |
| 2002-08-13 | vs NYA | 119 | L 5-10 | 47-72 | 4 | 28,834 | Jeff Suppan | Roger Clemens | Roger Clemens | Jeff Suppan | | 532 | 638 | -106 |
| 2002-08-14 | vs NYA | 120 | L 2-3 | 47-73 | 4 | 26,383 | Paul Byrd | Andy Pettitte | Ramiro Mendoza | Blake Stein | Mariano Rivera | 534 | 641 | -107 |
| 2002-08-15 | vs NYA | 121 | L 5-7 | 47-74 | 4 | 27,565 | Miguel Asencio | Orlando Hernandez | Mike Stanton | Roberto Hernandez | Mariano Rivera | 539 | 648 | -109 |
| 2002-08-16 | @ TBA | 122 | W 6-5 | 48-74 | 4 | 10,311 | Shawn Sedlacek | Victor Zambrano | Ryan Bukvich | Esteban Yan | Roberto Hernandez | 545 | 653 | -108 |
| 2002-08-17 | @ TBA | 123 | W 7-3 | 49-74 | 4 | 10,892 | Darrell May | Jorge Sosa | Scott Mullen | Jesus Colome | Roberto Hernandez | 552 | 656 | -104 |
| 2002-08-18 | @ TBA | 124 | L 6-8 | 49-75 | 4 | 10,607 | Jeff Suppan | Tanyon Sturtze | Tanyon Sturtze | Jeff Suppan | | 558 | 664 | -106 |
| 2002-08-19 | @ TOR | 125 | L 0-2 | 49-76 | 4 | 16,218 | Paul Byrd | Pete Walker | Pete Walker | Paul Byrd | Kelvim Escobar | 558 | 666 | -108 |
| 2002-08-20 | @ TOR | 126 | W 6-5 | 50-76 | 4 | 20,002 | Miguel Asencio | Justin Miller | Jeremy Affeldt | Scott Cassidy | Roberto Hernandez | 564 | 671 | -107 |
| 2002-08-21 | @ TOR | 127 | W 7-4 | 51-76 | 4 | 25,304 | Shawn Sedlacek | Roy Halladay | Shawn Sedlacek | Roy Halladay | Roberto Hernandez | 571 | 675 | -104 |
| 2002-08-22 | vs MIN | 128 | L 6-8 | 51-77 | 4 | 11,785 | Runelvys Hernandez | Johan Santana | Johan Santana | Runelvys Hernandez | Eddie Guardado | 577 | 683 | -106 |
| 2002-08-23 | vs MIN | 129 | L 2-9 | 51-78 | 4 | 29,685 | Jeff Suppan | Rick Reed | Rick Reed | Jeff Suppan | | 579 | 692 | -113 |
| 2002-08-24 | vs MIN | 130 | L 5-6 | 51-79 | 4 | 22,180 | Paul Byrd | Brad Radke | Brad Radke | Paul Byrd | Eddie Guardado | 584 | 698 | -114 |
| 2002-08-25 | vs MIN | 131 | W 4-2 | 52-79 | 4 | 13,440 | Miguel Asencio | Kyle Lohse | Miguel Asencio | Kyle Lohse | Roberto Hernandez | 588 | 700 | -112 |
| 2002-08-26 | vs OAK | 132 | L 3-6 | 52-80 | 4 | 11,096 | Darrell May | Cory Lidle | Cory Lidle | Darrell May | Billy Koch | 591 | 706 | -115 |
| 2002-08-27 | vs OAK | 133 | L 4-6 | 52-81 | 4 | 13,077 | Runelvys Hernandez | Mark Mulder | Mark Mulder | Runelvys Hernandez | Billy Koch | 595 | 712 | -117 |
| 2002-08-28 | vs OAK | 134 | L 1-7 | 52-82 | 4 | 15,952 | Shawn Sedlacek | Barry Zito | Barry Zito | Shawn Sedlacek | | 596 | 719 | -123 |
| 2002-08-30 | @ SEA | 135 | W 5-1 | 53-82 | 4 | 45,260 | Paul Byrd | Freddy Garcia | Paul Byrd | Freddy Garcia | Jason Grimsley | 601 | 720 | -119 |
| 2002-08-31 | @ SEA | 136 | W 4-2 | 54-82 | 4 | 45,500 | Miguel Asencio | Ryan Franklin | Jeremy Affeldt | Arthur Rhodes | Roberto Hernandez | 605 | 722 | -117 |
| 2002-09-01 | @ SEA | 137 | L 4-9 | 54-83 | 4 | 45,461 | Jeff Suppan | Ismael Valdez | Ismael Valdez | Jeff Suppan | | 609 | 731 | -122 |
| 2002-09-02 | @ OAK | 138 | L 6-7 | 54-84 | 4 | 26,325 | Runelvys Hernandez | Barry Zito | Billy Koch | Jason Grimsley | | 615 | 738 | -123 |
| 2002-09-04 | @ OAK | 139 | L 11-12 | 54-85 | 4 | 55,528 | Paul Byrd | Tim Hudson | Billy Koch | Jason Grimsley | | 626 | 750 | -124 |
| 2002-09-06 | vs SEA | 140 | L 7-14 | 54-86 | 4 | 13,363 | Shawn Sedlacek | Freddy Garcia | Freddy Garcia | Shawn Sedlacek | | 633 | 764 | -131 |
| 2002-09-07 | vs SEA | 141 | L 2-9 | 54-87 | 4 | 19,775 | Miguel Asencio | Ryan Franklin | Ryan Franklin | Miguel Asencio | | 635 | 773 | -138 |
| 2002-09-08 | vs SEA | 142 | L 9-16 | 54-88 | 4 | 11,442 | Jeff Suppan | Ismael Valdez | Doug Creek | Blake Stein | | 644 | 789 | -145 |
| 2002-09-09 | vs CHA | 143 | L 6-10 | 54-89 | 4 | 9,555 | Paul Byrd | Dan Wright | Dan Wright | Paul Byrd | | 650 | 799 | -149 |
| 2002-09-10 | vs CHA | 144 | L 4-12 | 54-90 | 4 | 10,106 | Runelvys Hernandez | Gary Glover | Mike Porzio | Runelvys Hernandez | Antonio Osuna | 654 | 811 | -157 |
| 2002-09-11 | vs CHA | 145 | W 9-6 | 55-90 | 4 | 12,104 | Darrell May | Mark Buehrle | Darrell May | Mark Buehrle | | 663 | 817 | -154 |
| 2002-09-12 | vs CHA | 146 | L 1-5 | 55-91 | 4 | 10,427 | Miguel Asencio | Jon Garland | Jon Garland | Miguel Asencio | | 664 | 822 | -158 |
| 2002-09-13 | @ DET | 147 | L 2-4 | 55-92 | 4 | 17,023 | Jeff Suppan | Nate Cornejo | Eric Eckenstahler | Scott Mullen | | 666 | 826 | -160 |
| 2002-09-14 | @ DET | 148 | W 5-1 | 56-92 | 4 | 18,693 | Paul Byrd | Andy Van Hekken | Paul Byrd | Andy Van Hekken | | 671 | 827 | -156 |
| 2002-09-15 | @ DET | 149 | W 9-3 | 57-92 | 4 | 20,991 | Runelvys Hernandez | Jason Beverlin | Runelvys Hernandez | Jason Beverlin | | 680 | 830 | -150 |
| 2002-09-16 | @ DET | 150 | L 2-5 | 57-93 | 4 | 10,469 | Darrell May | Mike Maroth | Mike Maroth | Darrell May | Franklyn German | 682 | 835 | -153 |
| 2002-09-17 | @ CHA | 151 | L 1-6 | 57-94 | 4 | 12,003 | Miguel Asencio | Mark Buehrle | Mark Buehrle | Miguel Asencio | Keith Foulke | 683 | 841 | -158 |
| 2002-09-18 | @ CHA | 152 | L 1-3 | 57-95 | 4 | 10,246 | Jeff Suppan | Jon Garland | Jon Garland | Jeff Suppan | Damaso Marte | 684 | 844 | -160 |
| 2002-09-19 | @ CHA | 153 | W 2-1 | 58-95 | 4 | 10,354 | Paul Byrd | Rocky Biddle | Paul Byrd | Rocky Biddle | Roberto Hernandez | 686 | 845 | -159 |
| 2002-09-20 | vs CLE | 154 | L 2-6 | 58-96 | 4 | 13,271 | Wes Obermueller | Jason Davis | Jason Davis | Wes Obermueller | Danys Baez | 688 | 851 | -163 |
| 2002-09-21 | vs CLE | 155 | W 3-2 | 59-96 | 4 | 15,448 | Runelvys Hernandez | Cliff Lee | Jason Grimsley | Terry Mulholland | | 691 | 853 | -162 |
| 2002-09-22 | vs CLE | 156 | L 5-6 | 59-97 | 4 | 11,177 | Darrell May | CC Sabathia | CC Sabathia | Jason Grimsley | Danys Baez | 696 | 859 | -163 |
| 2002-09-24 | vs DET | 157 | W 17-2 | 60-97 | 4 | 9,878 | Miguel Asencio | Shane Loux | Miguel Asencio | Shane Loux | | 713 | 861 | -148 |
| 2002-09-25 | vs DET | 158 | L 6-7 | 60-98 | 4 | 10,203 | Paul Byrd | Steve Sparks | Adam Bernero | Jeremy Hill | | 719 | 868 | -149 |
| 2002-09-26 | vs DET | 159 | W 7-2 | 61-98 | 4 | 11,092 | Jeff Suppan | Nate Cornejo | Jeff Suppan | Nate Cornejo | | 726 | 870 | -144 |
| 2002-09-27 | @ CLE | 160 | L 3-8 | 61-99 | 4 | 27,706 | Wes Obermueller | CC Sabathia | CC Sabathia | Wes Obermueller | | 729 | 878 | -149 |
| 2002-09-28 | @ CLE | 161 | L 5-6 | 61-100 | 4 | 31,428 | Runelvys Hernandez | Dave Burba | Mark Wohlers | Mike MacDougal | | 734 | 884 | -150 |
| 2002-09-29 | @ CLE | 162 | L 3-7 | 61-101 | 4 | 32,018 | Darrell May | Roy Smith | Jaret Wright | Scott Mullen | | 737 | 891 | -154 |