| 2001-04-02 | vs CHA | 1 | L 4-7 | 0-1 | 2 | 42,606 | Bartolo Colon | David Wells | David Wells | Bartolo Colon | Keith Foulke | 4 | 7 | -3 |
| 2001-04-04 | vs CHA | 2 | W 8-4 | 1-1 | 3 | 32,763 | Chuck Finley | Cal Eldred | Chuck Finley | Cal Eldred | | 12 | 11 | 1 |
| 2001-04-06 | vs BAL | 3 | W 4-3 | 2-1 | 2 | 32,738 | Dave Burba | Jose Mercedes | Ricardo Rincon | Jose Mercedes | Bob Wickman | 16 | 14 | 2 |
| 2001-04-07 | vs BAL | 4 | L 2-4 | 2-2 | 2 | 40,704 | Bartolo Colon | Pat Hentgen | Mike Trombley | Steve Reed | Ryan Kohlmeier | 18 | 18 | 0 |
| 2001-04-08 | vs BAL | 5 | W 4-3 | 3-2 | 1 | 40,754 | CC Sabathia | Chuck McElroy | Justin Speier | Calvin Maduro | Bob Wickman | 22 | 21 | 1 |
| 2001-04-09 | @ CHA | 6 | L 2-9 | 3-3 | 2 | 21,242 | Chuck Finley | Rocky Biddle | Rocky Biddle | Chuck Finley | | 24 | 30 | -6 |
| 2001-04-10 | @ CHA | 7 | L 7-8 | 3-4 | 3 | 12,465 | Tim Drew | Jim Parque | Gary Glover | Paul Shuey | Keith Foulke | 31 | 38 | -7 |
| 2001-04-11 | @ CHA | 8 | L 6-7 | 3-5 | 3 | 12,693 | Dave Burba | Cal Eldred | Sean Lowe | Dave Burba | Keith Foulke | 37 | 45 | -8 |
| 2001-04-12 | @ DET | 9 | W 5-3 | 4-5 | 3 | 15,639 | Bartolo Colon | Chris Holt | Bartolo Colon | Chris Holt | Bob Wickman | 42 | 48 | -6 |
| 2001-04-13 | @ DET | 10 | W 9-8 | 5-5 | 2 | 20,334 | CC Sabathia | Jeff Weaver | CC Sabathia | Jeff Weaver | Paul Shuey | 51 | 56 | -5 |
| 2001-04-14 | @ DET | 11 | L 0-1 | 5-6 | 2 | 23,119 | Chuck Finley | Steve Sparks | Steve Sparks | Chuck Finley | | 51 | 57 | -6 |
| 2001-04-17 | @ BAL | 12 | W 8-1 | 6-6 | 2 | 28,679 | Dave Burba | Jose Mercedes | Dave Burba | Jose Mercedes | | 59 | 58 | 1 |
| 2001-04-18 | @ BAL | 13 | W 4-1 | 7-6 | 2 | 28,801 | Bartolo Colon | Pat Hentgen | Bartolo Colon | Pat Hentgen | | 63 | 59 | 4 |
| 2001-04-19 | @ BAL | 14 | W 11-5 | 8-6 | 2 | 34,100 | CC Sabathia | Chuck McElroy | CC Sabathia | Chuck McElroy | | 74 | 64 | 10 |
| 2001-04-20 | vs DET | 15 | W 5-4 | 9-6 | 2 | 33,127 | Chuck Finley | Steve Sparks | Bob Wickman | C.J. Nitkowski | | 79 | 68 | 11 |
| 2001-04-21 | vs DET | 16 | W 5-4 | 10-6 | 2 | 42,068 | Tim Drew | Matt Perisho | Steve Reed | Todd Jones | | 84 | 72 | 12 |
| 2001-04-22 | vs DET | 17 | W 11-3 | 11-6 | 2 | 34,125 | Dave Burba | Dave Mlicki | Dave Burba | Dave Mlicki | | 95 | 75 | 20 |
| 2001-04-24 | vs ANA | 18 | L 2-7 | 11-7 | 2 | 31,942 | Bartolo Colon | Scott Schoeneweis | Scott Schoeneweis | Bartolo Colon | | 97 | 82 | 15 |
| 2001-04-25 | vs ANA | 19 | L 1-3 | 11-8 | 2 | 31,396 | CC Sabathia | Ismael Valdez | Ismael Valdez | CC Sabathia | Troy Percival | 98 | 85 | 13 |
| 2001-04-26 | vs ANA | 20 | W 6-5 | 12-8 | 2 | 29,427 | Chuck Finley | Pat Rapp | Paul Shuey | Shigetoshi Hasegawa | Bob Wickman | 104 | 90 | 14 |
| 2001-04-27 | vs TEX | 21 | L 9-11 | 12-9 | 2 | 40,320 | Tim Drew | Darren Oliver | Pat Mahomes | Tim Drew | Jeff Zimmerman | 113 | 101 | 12 |
| 2001-04-28 | vs TEX | 22 | W 7-3 | 13-9 | 2 | 41,147 | Dave Burba | Rick Helling | Dave Burba | Rick Helling | | 120 | 104 | 16 |
| 2001-04-29 | vs TEX | 23 | W 9-2 | 14-9 | 2 | 40,132 | Bartolo Colon | Doug Davis | Bartolo Colon | Doug Davis | | 129 | 106 | 23 |
| 2001-05-01 | @ KCA | 24 | W 13-2 | 15-9 | 2 | 14,512 | Chuck Finley | Chad Durbin | Chuck Finley | Chad Durbin | | 142 | 108 | 34 |
| 2001-05-02 | @ KCA | 25 | W 8-4 | 16-9 | 2 | 13,401 | CC Sabathia | Mac Suzuki | CC Sabathia | Mac Suzuki | | 150 | 112 | 38 |
| 2001-05-03 | @ KCA | 26 | W 9-4 | 17-9 | 2 | 23,869 | Dave Burba | Dan Reichert | Dave Burba | Dan Reichert | | 159 | 116 | 43 |
| 2001-05-04 | @ TBA | 27 | W 8-6 | 18-9 | 2 | 16,478 | Bartolo Colon | Albie Lopez | Bartolo Colon | Albie Lopez | Paul Shuey | 167 | 122 | 45 |
| 2001-05-05 | @ TBA | 28 | W 9-4 | 19-9 | 2 | 16,180 | Tim Drew | Paul Wilson | Justin Speier | Paul Wilson | Steve Karsay | 176 | 126 | 50 |
| 2001-05-06 | @ TBA | 29 | W 10-3 | 20-9 | 2 | 19,511 | Chuck Finley | Bryan Rekar | Chuck Finley | Doug Creek | | 186 | 129 | 57 |
| 2001-05-08 | vs KCA | 30 | W 8-4 | 21-9 | 2 | 31,537 | Dave Burba | Mac Suzuki | Dave Burba | Tony Cogan | | 194 | 133 | 61 |
| 2001-05-09 | vs KCA | 31 | W 5-1 | 22-9 | 1 | 32,664 | CC Sabathia | Dan Reichert | CC Sabathia | Dan Reichert | | 199 | 134 | 65 |
| 2001-05-10 | vs KCA | 32 | L 3-8 | 22-10 | 2 | 34,502 | Bartolo Colon | Brian Meadows | Brian Meadows | Bartolo Colon | | 202 | 142 | 60 |
| 2001-05-11 | vs TBA | 33 | W 10-6 | 23-10 | 2 | 42,009 | Tim Drew | Bryan Rekar | Rich Rodriguez | Bryan Rekar | | 212 | 148 | 64 |
| 2001-05-12 | vs TBA | 34 | W 8-0 | 24-10 | 1 | 40,399 | Chuck Finley | Brian Rose | Chuck Finley | Brian Rose | | 220 | 148 | 72 |
| 2001-05-13 | vs TBA | 35 | L 0-7 | 24-11 | 2 | 41,399 | Dave Burba | Tanyon Sturtze | Tanyon Sturtze | Dave Burba | | 220 | 155 | 65 |
| 2001-05-15 | @ TEX | 36 | W 8-6 | 25-11 | 2 | 39,348 | CC Sabathia | Doug Davis | CC Sabathia | Doug Davis | Bob Wickman | 228 | 161 | 67 |
| 2001-05-16 | @ TEX | 37 | W 4-3 | 26-11 | 2 | 33,695 | Bartolo Colon | Ryan Glynn | Paul Shuey | Tim Crabtree | Bob Wickman | 232 | 164 | 68 |
| 2001-05-17 | @ TEX | 38 | L 7-12 | 26-12 | 2 | 37,191 | Chuck Finley | Kenny Rogers | Kenny Rogers | Chuck Finley | | 239 | 176 | 63 |
| 2001-05-18 | @ ANA | 39 | W 7-2 | 27-12 | 2 | 39,177 | Dave Burba | Pat Rapp | Dave Burba | Pat Rapp | | 246 | 178 | 68 |
| 2001-05-19 | @ ANA | 40 | W 4-3 | 28-12 | 2 | 40,019 | Jaret Wright | Jarrod Washburn | Paul Shuey | Troy Percival | Bob Wickman | 250 | 181 | 69 |
| 2001-05-20 | @ ANA | 41 | L 6-9 | 28-13 | 2 | 36,339 | CC Sabathia | Ismael Valdez | Al Levine | Rich Rodriguez | Troy Percival | 256 | 190 | 66 |
| 2001-05-22 | vs DET | 42 | L 0-3 | 28-14 | 2 | 35,362 | Bartolo Colon | Jeff Weaver | Jeff Weaver | Bartolo Colon | Todd Jones | 256 | 193 | 63 |
| 2001-05-23 | vs DET | 43 | W 4-3 | 29-14 | 2 | 36,804 | Chuck Finley | Steve Sparks | Bob Wickman | Dave Borkowski | | 260 | 196 | 64 |
| 2001-05-24 | vs DET | 44 | W 8-5 | 30-14 | 1 | 36,295 | Dave Burba | Victor Santos | Dave Burba | Victor Santos | Bob Wickman | 268 | 201 | 67 |
| 2001-05-25 | vs NYA | 45 | W 6-4 | 31-14 | 1 | 42,455 | Jaret Wright | Orlando Hernandez | Rich Rodriguez | Orlando Hernandez | Bob Wickman | 274 | 205 | 69 |
| 2001-05-26 | vs NYA | 46 | L 5-12 | 31-15 | 1 | 42,528 | CC Sabathia | Roger Clemens | Roger Clemens | CC Sabathia | | 279 | 217 | 62 |
| 2001-05-27 | vs NYA | 47 | L 2-6 | 31-16 | 2 | 42,570 | Bartolo Colon | Ted Lilly | Ted Lilly | Bartolo Colon | Mariano Rivera | 281 | 223 | 58 |
| 2001-05-28 | @ DET | 48 | L 6-12 | 31-17 | 2 | 24,615 | Chuck Finley | Steve Sparks | Steve Sparks | Chuck Finley | | 287 | 235 | 52 |
| 2001-05-29 | @ DET | 49 | W 6-4 | 32-17 | 2 | 21,404 | Dave Burba | Victor Santos | Paul Shuey | Heath Murray | Bob Wickman | 293 | 239 | 54 |
| 2001-05-30 | @ DET | 50 | W 8-4 | 33-17 | 2 | 18,359 | Jaret Wright | Chris Holt | Jaret Wright | Chris Holt | Bob Wickman | 301 | 243 | 58 |
| 2001-06-01 | @ NYA | 51 | W 7-4 | 34-17 | 2 | 42,032 | CC Sabathia | Ted Lilly | CC Sabathia | Ted Lilly | Ricardo Rincon | 308 | 247 | 61 |
| 2001-06-02 | @ NYA | 52 | L 4-9 | 34-18 | 2 | 46,618 | Bartolo Colon | Roger Clemens | Roger Clemens | Bartolo Colon | Mariano Rivera | 312 | 256 | 56 |
| 2001-06-03 | @ NYA | 53 | W 4-3 | 35-18 | 2 | 47,300 | Charles Nagy | Andy Pettitte | Charles Nagy | Andy Pettitte | Bob Wickman | 316 | 259 | 57 |
| 2001-06-04 | @ MIN | 54 | L 10-11 | 35-19 | 2 | 20,613 | Dave Burba | Joe Mays | Eddie Guardado | Paul Shuey | | 326 | 270 | 56 |
| 2001-06-05 | @ MIN | 55 | W 5-0 | 36-19 | 2 | 22,022 | Jaret Wright | J.C. Romero | Jaret Wright | J.C. Romero | | 331 | 270 | 61 |
| 2001-06-06 | @ MIN | 56 | W 5-2 | 37-19 | 1 | 24,031 | CC Sabathia | Brad Thomas | Paul Shuey | Jack Cressend | Bob Wickman | 336 | 272 | 64 |
| 2001-06-07 | @ MIN | 57 | W 6-2 | 38-19 | 1 | 24,671 | Bartolo Colon | Brad Radke | Bartolo Colon | Brad Radke | | 342 | 274 | 68 |
| 2001-06-08 | vs CIN | 58 | L 4-7 | 38-20 | 1 | 42,512 | Charles Nagy | Rob Bell | Jim Brower | Rich Rodriguez | Danny Graves | 346 | 281 | 65 |
| 2001-06-09 | vs CIN | 59 | W 10-2 | 39-20 | 1 | 42,521 | Dave Burba | Osvaldo Fernandez | Dave Burba | Osvaldo Fernandez | | 356 | 283 | 73 |
| 2001-06-10 | vs CIN | 60 | L 3-9 | 39-21 | 1 | 49,479 | Jaret Wright | Chris Reitsma | Chris Reitsma | Jaret Wright | | 359 | 292 | 67 |
| 2001-06-12 | vs MIL | 61 | L 2-4 | 39-22 | 2 | 39,192 | CC Sabathia | Jimmy Haynes | Chad Fox | Paul Shuey | Curt Leskanic | 361 | 296 | 65 |
| 2001-06-13 | vs MIL | 62 | W 5-2 | 40-22 | 2 | 35,679 | Bartolo Colon | Allen Levrault | Bob Wickman | Chad Fox | | 366 | 298 | 68 |
| 2001-06-14 | vs MIL | 63 | L 4-9 | 40-23 | 2 | 41,610 | Charles Nagy | Ben Sheets | Ben Sheets | Charles Nagy | | 370 | 307 | 63 |
| 2001-06-15 | @ PIT | 64 | L 3-6 | 40-24 | 2 | 36,235 | Dave Burba | Jimmy Anderson | Jimmy Anderson | Dave Burba | Mike Williams | 373 | 313 | 60 |
| 2001-06-16 | @ PIT | 65 | L 4-6 | 40-25 | 2 | 37,056 | Jaret Wright | Jason Schmidt | Jason Schmidt | Jaret Wright | Mike Williams | 377 | 319 | 58 |
| 2001-06-17 | @ PIT | 66 | L 0-1 | 40-26 | 2 | 36,694 | CC Sabathia | Todd Ritchie | Todd Ritchie | Steve Karsay | | 377 | 320 | 57 |
| 2001-06-19 | vs MIN | 67 | L 9-10 | 40-27 | 2 | 39,190 | Bartolo Colon | Eric Milton | Bob Wells | Charles Nagy | | 386 | 330 | 56 |
| 2001-06-20 | vs MIN | 68 | W 4-2 | 41-27 | 2 | 40,213 | Chuck Finley | Joe Mays | Jake Westbrook | Joe Mays | Bob Wickman | 390 | 332 | 58 |
| 2001-06-21 | vs MIN | 69 | W 9-6 | 42-27 | 1 | 39,755 | Jaret Wright | J.C. Romero | Steve Woodard | J.C. Romero | Ricardo Rincon | 399 | 338 | 61 |
| 2001-06-22 | @ KCA | 70 | W 6-5 | 43-27 | 1 | 31,572 | CC Sabathia | Paul Byrd | CC Sabathia | Blake Stein | Bob Wickman | 405 | 343 | 62 |
| 2001-06-23 | @ KCA | 71 | L 2-3 | 43-28 | 1 | 29,808 | Dave Burba | Chad Durbin | Chad Durbin | Dave Burba | Roberto Hernandez | 407 | 346 | 61 |
| 2001-06-24 | @ KCA | 72 | W 4-2 | 44-28 | 1 | 25,127 | Bartolo Colon | Jeff Suppan | Bartolo Colon | Jeff Suppan | John Rocker | 411 | 348 | 63 |
| 2001-06-25 | @ NYA | 73 | L 7-8 | 44-29 | 1 | 40,852 | Chuck Finley | Randy Keisler | Jay Witasick | Ricardo Rincon | Mariano Rivera | 418 | 356 | 62 |
| 2001-06-26 | @ NYA | 74 | W 5-3 | 45-29 | 1 | 40,346 | Charles Nagy | Adrian Hernandez | Charles Nagy | Adrian Hernandez | John Rocker | 423 | 359 | 64 |
| 2001-06-27 | @ NYA | 75 | L 5-15 | 45-30 | 2 | 45,539 | CC Sabathia | Mike Mussina | Mike Mussina | CC Sabathia | | 428 | 374 | 54 |
| 2001-06-29 | vs KCA | 76 | L 3-5 | 45-31 | 2 | 42,500 | Dave Burba | Jeff Suppan | Jeff Suppan | Dave Burba | Roberto Hernandez | 431 | 379 | 52 |
| 2001-06-30 | vs KCA | 77 | L 7-11 | 45-32 | 2 | 42,446 | Bartolo Colon | Kris Wilson | Kris Wilson | Bartolo Colon | | 438 | 390 | 48 |
| 2001-07-01 | vs KCA | 78 | L 11-13 | 45-33 | 2 | 42,457 | Charles Nagy | Dan Reichert | Blake Stein | Charles Nagy | Roberto Hernandez | 449 | 403 | 46 |
| 2001-07-02 | vs KCA | 79 | W 2-1 | 46-33 | 2 | 40,248 | CC Sabathia | Paul Byrd | John Rocker | Tony Cogan | | 451 | 404 | 47 |
| 2001-07-03 | vs BOS | 80 | W 9-1 | 47-33 | 2 | 42,520 | Jake Westbrook | Tomo Ohka | Jake Westbrook | Tomo Ohka | | 460 | 405 | 55 |
| 2001-07-04 | vs BOS | 81 | L 4-13 | 47-34 | 2 | 42,382 | Dave Burba | Tim Wakefield | Tim Wakefield | Dave Burba | | 464 | 418 | 46 |
| 2001-07-05 | vs BOS | 82 | L 4-5 | 47-35 | 2 | 42,647 | Bartolo Colon | David Cone | Derek Lowe | John Rocker | | 468 | 423 | 45 |
| 2001-07-06 | vs SLN | 83 | W 14-2 | 48-35 | 2 | 42,394 | Charles Nagy | Matt Morris | Charles Nagy | Matt Morris | | 482 | 425 | 57 |
| 2001-07-07 | vs SLN | 84 | W 7-6 | 49-35 | 2 | 42,467 | CC Sabathia | Andy Benes | John Rocker | Dave Veres | | 489 | 431 | 58 |
| 2001-07-08 | vs SLN | 85 | L 3-4 | 49-36 | 2 | 42,431 | Jake Westbrook | Dustin Hermanson | Mike Timlin | John Rocker | | 492 | 435 | 57 |
| 2001-07-12 | @ CIN | 86 | W 7-0 | 50-36 | 2 | 28,816 | Bartolo Colon | Chris Reitsma | Bartolo Colon | Chris Reitsma | | 499 | 435 | 64 |
| 2001-07-13 | @ CIN | 87 | W 5-1 | 51-36 | 2 | 38,790 | CC Sabathia | Elmer Dessens | CC Sabathia | Elmer Dessens | | 504 | 436 | 68 |
| 2001-07-14 | @ CIN | 88 | L 5-6 | 51-37 | 2 | 40,794 | Dave Burba | Jim Brower | Danny Graves | John Rocker | | 509 | 442 | 67 |
| 2001-07-15 | @ HOU | 89 | L 3-5 | 51-38 | 2 | 39,127 | Jake Westbrook | Tim Redding | Tim Redding | Jake Westbrook | Billy Wagner | 512 | 447 | 65 |
| 2001-07-16 | @ HOU | 90 | L 8-10 | 51-39 | 2 | 30,834 | Charles Nagy | Scott Elarton | Ron Villone | John Rocker | | 520 | 457 | 63 |
| 2001-07-17 | @ HOU | 91 | W 10-4 | 52-39 | 2 | 32,284 | Bartolo Colon | Shane Reynolds | Bartolo Colon | Shane Reynolds | | 530 | 461 | 69 |
| 2001-07-18 | @ CHA | 92 | W 9-4 | 53-39 | 2 | 22,634 | CC Sabathia | Mark Buehrle | CC Sabathia | Mark Buehrle | | 539 | 465 | 74 |
| 2001-07-19 | @ CHA | 93 | W 10-3 | 54-39 | 2 | 23,450 | Dave Burba | Sean Lowe | Dave Burba | Sean Lowe | | 549 | 468 | 81 |
| 2001-07-20 | vs DET | 94 | L 3-7 | 54-40 | 2 | 42,520 | Jake Westbrook | Chris Holt | Chris Holt | Jake Westbrook | | 552 | 475 | 77 |
| 2001-07-21 | vs DET | 95 | W 8-4 | 55-40 | 2 | 42,316 | Charles Nagy | Adam Pettyjohn | Charles Nagy | Adam Pettyjohn | | 560 | 479 | 81 |
| 2001-07-22 | vs DET | 96 | W 6-3 | 56-40 | 2 | 42,462 | Bartolo Colon | Jeff Weaver | Bartolo Colon | Jeff Weaver | | 566 | 482 | 84 |
| 2001-07-23 | vs CHA | 97 | W 2-0 | 57-40 | 1 | 41,317 | CC Sabathia | Mark Buehrle | CC Sabathia | Mark Buehrle | Bob Wickman | 568 | 482 | 86 |
| 2001-07-24 | vs CHA | 98 | L 1-4 | 57-41 | 1 | 42,175 | Dave Burba | Sean Lowe | Sean Lowe | Dave Burba | Keith Foulke | 569 | 486 | 83 |
| 2001-07-25 | vs CHA | 99 | W 7-5 | 58-41 | 1 | 42,645 | Jake Westbrook | Rocky Biddle | Jake Westbrook | Rocky Biddle | Bob Wickman | 576 | 491 | 85 |
| 2001-07-26 | vs CHA | 100 | L 4-5 | 58-42 | 2 | 42,054 | Charles Nagy | Gary Glover | Matt Ginter | Charles Nagy | Keith Foulke | 580 | 496 | 84 |
| 2001-07-27 | @ DET | 101 | W 7-4 | 59-42 | 1 | 39,504 | Bartolo Colon | Adam Pettyjohn | Bartolo Colon | Adam Pettyjohn | Bob Wickman | 587 | 500 | 87 |
| 2001-07-28 | @ DET | 102 | W 6-4 | 60-43 | 1 | 27,643 | CC Sabathia | Victor Santos | Danys Baez | Heath Murray | Bob Wickman | 593 | 504 | 89 |
| 2001-07-28 | @ DET | 103 | L 2-4 | 60-43 | 1 | 34,916 | Steve Woodard | Jeff Weaver | Jeff Weaver | Steve Woodard | Matt Anderson | 595 | 508 | 87 |
| 2001-07-29 | @ DET | 104 | L 3-8 | 60-44 | 1 | 32,918 | Dave Burba | Steve Sparks | Steve Sparks | Dave Burba | | 598 | 516 | 82 |
| 2001-07-31 | vs OAK | 105 | L 2-11 | 60-45 | 1 | 38,830 | Jake Westbrook | Cory Lidle | Cory Lidle | Jake Westbrook | | 600 | 527 | 73 |
| 2001-08-01 | vs OAK | 106 | W 6-5 | 61-45 | 1 | 40,592 | Charles Nagy | Erik Hiljus | Danys Baez | Jim Mecir | Bob Wickman | 606 | 532 | 74 |
| 2001-08-02 | vs OAK | 107 | L 4-17 | 61-46 | 1 | 38,226 | CC Sabathia | Mark Mulder | Mark Mulder | CC Sabathia | | 610 | 549 | 61 |
| 2001-08-03 | vs SEA | 108 | L 1-2 | 61-47 | 2 | 42,580 | Bartolo Colon | Jamie Moyer | Jamie Moyer | Bartolo Colon | Kazuhiro Sasaki | 611 | 551 | 60 |
| 2001-08-04 | vs SEA | 109 | L 5-8 | 61-48 | 2 | 42,440 | Steve Woodard | Freddy Garcia | Freddy Garcia | Danys Baez | Arthur Rhodes | 616 | 559 | 57 |
| 2001-08-05 | vs SEA | 110 | W 15-14 | 62-48 | 2 | 42,494 | Dave Burba | Aaron Sele | John Rocker | Jose Paniagua | | 631 | 573 | 58 |
| 2001-08-06 | vs SEA | 111 | L 6-8 | 62-49 | 2 | 42,058 | Charles Nagy | Paul Abbott | Paul Abbott | Charles Nagy | Jose Paniagua | 637 | 581 | 56 |
| 2001-08-07 | @ MIN | 112 | W 7-2 | 63-49 | 1 | 28,192 | CC Sabathia | Rick Reed | CC Sabathia | Rick Reed | | 644 | 583 | 61 |
| 2001-08-08 | @ MIN | 113 | W 8-2 | 64-49 | 1 | 38,444 | Bartolo Colon | Kyle Lohse | Danys Baez | Bob Wells | | 652 | 585 | 67 |
| 2001-08-09 | @ MIN | 114 | L 4-6 | 64-50 | 1 | 30,080 | Chuck Finley | Eric Milton | Eric Milton | Chuck Finley | LaTroy Hawkins | 656 | 591 | 65 |
| 2001-08-10 | @ TEX | 115 | L 2-7 | 64-51 | 1 | 47,242 | Steve Woodard | Doug Davis | Doug Davis | Steve Woodard | | 658 | 598 | 60 |
| 2001-08-11 | @ TEX | 116 | L 5-6 | 64-52 | 1 | 43,145 | Charles Nagy | Darren Oliver | Mark Petkovsek | John Rocker | Jeff Zimmerman | 663 | 604 | 59 |
| 2001-08-12 | @ TEX | 117 | W 13-2 | 65-52 | 1 | 28,765 | CC Sabathia | Rob Bell | CC Sabathia | Rob Bell | | 676 | 606 | 70 |
| 2001-08-14 | vs MIN | 118 | W 8-7 | 66-52 | 1 | 42,619 | Bartolo Colon | Eric Milton | Danys Baez | Bob Wells | | 684 | 613 | 71 |
| 2001-08-15 | vs MIN | 119 | W 8-2 | 67-52 | 1 | 41,602 | Chuck Finley | Joe Mays | Chuck Finley | Joe Mays | | 692 | 615 | 77 |
| 2001-08-16 | vs MIN | 120 | W 6-1 | 68-52 | 1 | 40,672 | Steve Woodard | Adam Johnson | Steve Woodard | Adam Johnson | | 698 | 616 | 82 |
| 2001-08-17 | vs ANA | 121 | L 2-7 | 68-53 | 1 | 42,528 | Charles Nagy | Ramon Ortiz | Ramon Ortiz | Charles Nagy | | 700 | 623 | 77 |
| 2001-08-18 | vs ANA | 122 | W 4-2 | 69-53 | 1 | 42,610 | CC Sabathia | Pat Rapp | CC Sabathia | Pat Rapp | Bob Wickman | 704 | 625 | 79 |
| 2001-08-19 | vs ANA | 123 | L 1-4 | 69-54 | 1 | 42,510 | Bartolo Colon | Jarrod Washburn | Jarrod Washburn | Bartolo Colon | Troy Percival | 705 | 629 | 76 |
| 2001-08-20 | @ OAK | 124 | L 0-9 | 69-55 | 1 | 18,133 | Chuck Finley | Barry Zito | Barry Zito | Chuck Finley | | 705 | 638 | 67 |
| 2001-08-21 | @ OAK | 125 | W 2-1 | 70-55 | 1 | 19,343 | Steve Woodard | Cory Lidle | Steve Woodard | Cory Lidle | Bob Wickman | 707 | 639 | 68 |
| 2001-08-22 | @ OAK | 126 | W 5-4 | 71-55 | 1 | 40,992 | Dave Burba | Erik Hiljus | Bob Wickman | Luis Vizcaino | David Riske | 712 | 643 | 69 |
| 2001-08-23 | @ OAK | 127 | W 9-7 | 72-55 | 1 | 22,281 | CC Sabathia | Mark Mulder | Charles Nagy | Mark Mulder | Bob Wickman | 721 | 650 | 71 |
| 2001-08-24 | @ SEA | 128 | L 1-4 | 72-56 | 1 | 45,767 | Bartolo Colon | Jamie Moyer | Jamie Moyer | Bartolo Colon | Norm Charlton | 722 | 654 | 68 |
| 2001-08-25 | @ SEA | 129 | L 2-3 | 72-57 | 1 | 45,818 | Chuck Finley | Freddy Garcia | John Halama | John Rocker | | 724 | 657 | 67 |
| 2001-08-26 | @ SEA | 130 | W 4-3 | 73-57 | 1 | 45,782 | Steve Woodard | Aaron Sele | David Riske | Jeff Nelson | Bob Wickman | 728 | 660 | 68 |
| 2001-08-28 | vs BOS | 131 | W 8-3 | 74-57 | 1 | 41,048 | Dave Burba | David Cone | Dave Burba | David Cone | | 736 | 663 | 73 |
| 2001-08-29 | vs BOS | 132 | W 2-1 | 75-57 | 1 | 41,320 | CC Sabathia | Casey Fossum | CC Sabathia | Casey Fossum | Bob Wickman | 738 | 664 | 74 |
| 2001-08-30 | vs BOS | 133 | W 3-1 | 76-57 | 1 | 40,616 | Bartolo Colon | Hideo Nomo | Bartolo Colon | Hideo Nomo | Bob Wickman | 741 | 665 | 76 |
| 2001-08-31 | @ CHA | 134 | L 8-11 | 76-58 | 1 | 24,097 | Steve Woodard | Dan Wright | Bob Howry | Jake Westbrook | Keith Foulke | 749 | 676 | 73 |
| 2001-09-01 | @ CHA | 135 | W 4-3 | 77-58 | 1 | 27,869 | Ryan Drese | Jon Garland | Ryan Drese | Jon Garland | Bob Wickman | 753 | 679 | 74 |
| 2001-09-02 | @ CHA | 136 | L 10-19 | 77-59 | 1 | 25,680 | Dave Burba | Rocky Biddle | Rocky Biddle | Dave Burba | | 763 | 698 | 65 |
| 2001-09-03 | @ CHA | 137 | W 6-3 | 78-59 | 1 | 28,135 | CC Sabathia | Gary Glover | CC Sabathia | Gary Glover | Bob Wickman | 769 | 701 | 68 |
| 2001-09-04 | @ BOS | 138 | W 8-5 | 79-59 | 1 | 32,145 | Bartolo Colon | Hideo Nomo | Bartolo Colon | Hideo Nomo | Bob Wickman | 777 | 706 | 71 |
| 2001-09-05 | @ BOS | 139 | L 7-10 | 79-60 | 1 | 32,029 | Steve Woodard | Casey Fossum | Rolando Arrojo | Steve Woodard | Ugueth Urbina | 784 | 716 | 68 |
| 2001-09-06 | @ BOS | 140 | W 6-4 | 80-60 | 1 | 32,500 | Chuck Finley | Frank Castillo | Chuck Finley | Frank Castillo | John Rocker | 790 | 720 | 70 |
| 2001-09-07 | vs CHA | 141 | L 7-10 | 80-61 | 1 | 42,487 | Dave Burba | Rocky Biddle | Rocky Biddle | Dave Burba | Keith Foulke | 797 | 730 | 67 |
| 2001-09-08 | vs CHA | 142 | W 8-7 | 81-61 | 1 | 42,488 | CC Sabathia | Gary Glover | Danys Baez | Keith Foulke | | 805 | 737 | 68 |
| 2001-09-09 | vs CHA | 143 | W 9-8 | 82-61 | 1 | 42,377 | Steve Woodard | Mark Buehrle | Bob Wickman | Keith Foulke | | 814 | 745 | 69 |
| 2001-09-10 | vs CHA | 144 | L 1-7 | 82-62 | 1 | 38,244 | Bartolo Colon | Dan Wright | Dan Wright | Bartolo Colon | | 815 | 752 | 63 |
| 2001-09-18 | vs KCA | 145 | W 11-2 | 83-62 | 1 | 34,795 | Chuck Finley | Chad Durbin | Chuck Finley | Chad Durbin | | 826 | 754 | 72 |
| 2001-09-19 | vs KCA | 146 | W 11-3 | 84-62 | 1 | 31,357 | Bartolo Colon | Jeff Suppan | Bartolo Colon | Jeff Suppan | | 837 | 757 | 80 |
| 2001-09-20 | vs KCA | 147 | L 2-4 | 84-63 | 1 | 33,912 | Ryan Drese | Chris George | Chris George | Ryan Drese | Roberto Hernandez | 839 | 761 | 78 |
| 2001-09-21 | @ MIN | 148 | L 2-6 | 84-64 | 1 | 20,038 | CC Sabathia | Rick Reed | Rick Reed | CC Sabathia | Eddie Guardado | 841 | 767 | 74 |
| 2001-09-22 | @ MIN | 149 | W 4-2 | 85-64 | 1 | 33,733 | Steve Woodard | Brad Radke | Ricardo Rincon | Brad Radke | Bob Wickman | 845 | 769 | 76 |
| 2001-09-23 | @ MIN | 150 | W 4-2 | 86-64 | 1 | 21,928 | Chuck Finley | Eric Milton | Chuck Finley | Eric Milton | Bob Wickman | 849 | 771 | 78 |
| 2001-09-24 | vs TOR | 151 | L 2-3 | 86-65 | 1 | 32,425 | Bartolo Colon | Roy Halladay | Bob File | Danys Baez | Scott Eyre | 851 | 774 | 77 |
| 2001-09-25 | vs TOR | 152 | W 11-7 | 87-65 | 1 | 35,729 | Ryan Drese | Chris Carpenter | David Riske | Dan Plesac | | 862 | 781 | 81 |
| 2001-09-28 | vs MIN | 153 | L 0-1 | 87-66 | 1 | 41,319 | CC Sabathia | Eric Milton | Eric Milton | Danys Baez | Eddie Guardado | 862 | 782 | 80 |
| 2001-09-29 | vs MIN | 154 | W 9-8 | 88-66 | 1 | 42,417 | Chuck Finley | Joe Mays | Jake Westbrook | Eddie Guardado | | 871 | 790 | 81 |
| 2001-09-30 | vs MIN | 155 | W 9-1 | 89-66 | 1 | 42,323 | Bartolo Colon | Rick Reed | Bartolo Colon | Rick Reed | | 880 | 791 | 89 |
| 2001-10-02 | @ KCA | 156 | L 1-5 | 89-67 | 1 | 12,016 | Ryan Drese | Blake Stein | Roberto Hernandez | John Rocker | | 881 | 796 | 85 |
| 2001-10-03 | @ KCA | 157 | W 4-1 | 90-67 | 1 | 12,581 | CC Sabathia | Mike MacDougal | CC Sabathia | Mike MacDougal | Bob Wickman | 885 | 797 | 88 |
| 2001-10-04 | @ KCA | 158 | L 4-8 | 90-68 | 1 | 12,672 | Bartolo Colon | Chad Durbin | Chad Durbin | Bartolo Colon | | 889 | 805 | 84 |
| 2001-10-05 | @ TOR | 159 | L 0-5 | 90-70 | 1 | 0 | Chuck Finley | Roy Halladay | Roy Halladay | Chuck Finley | | 889 | 810 | 79 |
| 2001-10-05 | @ TOR | 160 | L 3-4 | 90-70 | 1 | 19,387 | Dave Burba | Esteban Loaiza | Bob File | Ryan Drese | | 892 | 814 | 78 |
| 2001-10-06 | @ TOR | 161 | L 2-5 | 90-71 | 1 | 20,762 | Tim Drew | Chris Carpenter | Chris Carpenter | Tim Drew | Paul Quantrill | 894 | 819 | 75 |
| 2001-10-07 | @ TOR | 162 | W 3-2 | 91-71 | 1 | 28,217 | CC Sabathia | Brandon Lyon | CC Sabathia | Brandon Lyon | John Rocker | 897 | 821 | 76 |