| 2001-04-02 | vs MON | 1 | L 4-5 | 0-1 | 1 | 38,466 | Jon Lieber | Javier Vazquez | Graeme Lloyd | Mike Fyhrie | Ugueth Urbina | 4 | 5 | -1 |
| 2001-04-04 | vs MON | 2 | L 2-3 | 0-2 | 4 | 23,070 | Kerry Wood | Britt Reames | Britt Reames | Kerry Wood | Ugueth Urbina | 6 | 8 | -2 |
| 2001-04-05 | vs MON | 3 | W 2-1 | 1-2 | 3 | 16,758 | Kevin Tapani | Tony Armas | Kevin Tapani | Tony Armas | Jeff Fassero | 8 | 9 | -1 |
| 2001-04-06 | @ PHI | 4 | W 3-2 | 2-2 | 2 | 36,380 | Julian Tavarez | Randy Wolf | Julian Tavarez | Randy Wolf | Jeff Fassero | 11 | 11 | 0 |
| 2001-04-07 | @ PHI | 5 | W 8-4 | 3-2 | 2 | 16,847 | Jason Bere | Omar Daal | Jason Bere | Vicente Padilla | | 19 | 15 | 4 |
| 2001-04-08 | @ PHI | 6 | L 1-3 | 3-3 | 2 | 15,550 | Jon Lieber | Robert Person | Robert Person | Jon Lieber | Jose Mesa | 20 | 18 | 2 |
| 2001-04-09 | @ MON | 7 | L 5-7 | 3-4 | 3 | 5,776 | Kerry Wood | Britt Reames | Graeme Lloyd | Manny Aybar | Ugueth Urbina | 25 | 25 | 0 |
| 2001-04-10 | @ MON | 8 | W 4-2 | 4-4 | 3 | 8,314 | Kevin Tapani | Tony Armas | Kevin Tapani | Tony Armas | Jeff Fassero | 29 | 27 | 2 |
| 2001-04-11 | @ MON | 9 | W 4-2 | 5-4 | 3 | 9,632 | Julian Tavarez | Mike Thurman | Julian Tavarez | Mike Thurman | Jeff Fassero | 33 | 29 | 4 |
| 2001-04-13 | vs PIT | 10 | W 4-2 | 6-4 | 2 | 26,003 | Jason Bere | Bronson Arroyo | Jason Bere | Bronson Arroyo | Jeff Fassero | 37 | 31 | 6 |
| 2001-04-14 | vs PIT | 11 | W 7-6 | 7-4 | 2 | 34,220 | Jon Lieber | Ramon Martinez | Manny Aybar | Jose Silva | Jeff Fassero | 44 | 37 | 7 |
| 2001-04-15 | vs PIT | 12 | W 5-1 | 8-4 | 1 | 21,061 | Kerry Wood | Todd Ritchie | Courtney Duncan | Scott Sauerbeck | | 49 | 38 | 11 |
| 2001-04-17 | vs PHI | 13 | L 3-6 | 8-5 | 1 | 18,189 | Julian Tavarez | Amaury Telemaco | Vicente Padilla | Jeff Fassero | Jose Mesa | 52 | 44 | 8 |
| 2001-04-18 | vs PHI | 14 | W 4-3 | 10-5 | 1 | 0 | Kevin Tapani | Bruce Chen | Kevin Tapani | Bruce Chen | Jeff Fassero | 56 | 47 | 9 |
| 2001-04-18 | vs PHI | 15 | W 5-3 | 10-5 | 1 | 26,793 | Jason Bere | Randy Wolf | Jason Bere | Randy Wolf | Jeff Fassero | 61 | 50 | 11 |
| 2001-04-20 | @ PIT | 16 | W 8-2 | 11-5 | 1 | 31,692 | Jon Lieber | Ramon Martinez | Jon Lieber | Ramon Martinez | | 69 | 52 | 17 |
| 2001-04-21 | @ PIT | 17 | W 4-3 | 12-5 | 1 | 33,105 | Kerry Wood | Todd Ritchie | Felix Heredia | Mike Williams | Jeff Fassero | 73 | 55 | 18 |
| 2001-04-22 | @ PIT | 18 | L 3-4 | 12-6 | 1 | 35,676 | Julian Tavarez | Jimmy Anderson | Mike Williams | Jeff Fassero | | 76 | 59 | 17 |
| 2001-04-24 | @ COL | 19 | L 1-14 | 12-7 | 1 | 43,562 | Kevin Tapani | Mike Hampton | Mike Hampton | Kevin Tapani | | 77 | 73 | 4 |
| 2001-04-25 | @ COL | 20 | L 5-6 | 12-8 | 1 | 42,514 | Jason Bere | Denny Neagle | Jose Jimenez | Courtney Duncan | | 82 | 79 | 3 |
| 2001-04-26 | @ COL | 21 | W 7-2 | 13-8 | 1 | 47,336 | Jon Lieber | Brian Bohanon | Jon Lieber | Brian Bohanon | | 89 | 81 | 8 |
| 2001-04-27 | @ SFN | 22 | W 7-3 | 14-8 | 1 | 41,059 | Kerry Wood | Mark Gardner | Kerry Wood | Mark Gardner | | 96 | 84 | 12 |
| 2001-04-28 | @ SFN | 23 | L 0-5 | 14-9 | 1 | 41,059 | Julian Tavarez | Shawn Estes | Shawn Estes | Julian Tavarez | | 96 | 89 | 7 |
| 2001-04-29 | @ SFN | 24 | W 11-2 | 15-9 | 1 | 41,059 | Manny Aybar | Livan Hernandez | Manny Aybar | Livan Hernandez | | 107 | 91 | 16 |
| 2001-05-01 | vs SDN | 25 | L 3-10 | 15-10 | 1 | 28,842 | Jason Bere | Brian Tollberg | Brian Tollberg | Jason Bere | | 110 | 101 | 9 |
| 2001-05-02 | vs SDN | 26 | W 8-3 | 16-10 | 1 | 27,016 | Jon Lieber | Kevin Jarvis | Jon Lieber | Kevin Jarvis | | 118 | 104 | 14 |
| 2001-05-03 | vs SDN | 27 | L 3-5 | 16-11 | 1 | 27,307 | Kerry Wood | Bobby Jones | Bobby Jones | Kerry Wood | Trevor Hoffman | 121 | 109 | 12 |
| 2001-05-04 | vs LAN | 28 | W 4-0 | 17-11 | 1 | 27,871 | Kevin Tapani | Chan Ho Park | Kevin Tapani | Chan Ho Park | | 125 | 109 | 16 |
| 2001-05-05 | vs LAN | 29 | W 20-1 | 18-11 | 1 | 38,468 | Julian Tavarez | Darren Dreifort | Julian Tavarez | Darren Dreifort | | 145 | 110 | 35 |
| 2001-05-06 | vs LAN | 30 | W 3-2 | 19-11 | 1 | 36,050 | Jason Bere | Eric Gagne | Tom Gordon | Matt Herges | | 148 | 112 | 36 |
| 2001-05-07 | @ MIL | 31 | W 7-6 | 20-11 | 1 | 30,239 | Jon Lieber | Paul Rigdon | Todd Van Poppel | David Weathers | Tom Gordon | 155 | 118 | 37 |
| 2001-05-08 | @ MIL | 32 | L 1-4 | 20-12 | 1 | 26,751 | Kerry Wood | Ben Sheets | Ben Sheets | Kerry Wood | Curt Leskanic | 156 | 122 | 34 |
| 2001-05-09 | @ MIL | 33 | W 6-3 | 21-12 | 1 | 30,616 | Kevin Tapani | Jamey Wright | Kevin Tapani | Jamey Wright | Tom Gordon | 162 | 125 | 37 |
| 2001-05-10 | @ MIL | 34 | L 1-11 | 21-13 | 1 | 36,149 | Julian Tavarez | Mark Leiter | Allen Levrault | Julian Tavarez | Mike DeJean | 163 | 136 | 27 |
| 2001-05-11 | @ SLN | 35 | L 2-7 | 21-14 | 1 | 47,444 | Jason Bere | Darryl Kile | Darryl Kile | Jason Bere | | 165 | 143 | 22 |
| 2001-05-12 | @ SLN | 36 | L 2-5 | 21-15 | 1 | 46,885 | Jon Lieber | Matt Morris | Matt Morris | Jon Lieber | Dave Veres | 167 | 148 | 19 |
| 2001-05-13 | @ SLN | 37 | L 4-13 | 21-16 | 2 | 46,167 | Kerry Wood | Andy Benes | Andy Benes | Kerry Wood | | 171 | 161 | 10 |
| 2001-05-15 | vs HOU | 38 | L 7-9 | 21-17 | 4 | 31,648 | Kevin Tapani | Jose Lima | Michael Jackson | Todd Van Poppel | Nelson Cruz | 178 | 170 | 8 |
| 2001-05-16 | vs HOU | 39 | L 2-6 | 21-18 | 4 | 31,206 | Julian Tavarez | Shane Reynolds | Shane Reynolds | Julian Tavarez | | 180 | 176 | 4 |
| 2001-05-17 | vs HOU | 40 | L 2-4 | 21-19 | 4 | 36,014 | Jason Bere | Scott Elarton | Roy Oswalt | Kyle Farnsworth | Billy Wagner | 182 | 180 | 2 |
| 2001-05-18 | vs ARI | 41 | L 0-4 | 21-20 | 4 | 37,830 | Jon Lieber | Randy Johnson | Randy Johnson | Jon Lieber | | 182 | 184 | -2 |
| 2001-05-19 | vs ARI | 42 | W 6-2 | 22-20 | 4 | 40,153 | Kerry Wood | Miguel Batista | Kerry Wood | Miguel Batista | | 188 | 186 | 2 |
| 2001-05-20 | vs ARI | 43 | W 6-5 | 23-20 | 3 | 39,350 | Kevin Tapani | Robert Ellis | Kevin Tapani | Robert Ellis | Jeff Fassero | 194 | 191 | 3 |
| 2001-05-22 | vs CIN | 44 | W 5-3 | 24-20 | 2 | 37,385 | Julian Tavarez | Brian Reith | Courtney Duncan | Jim Brower | Tom Gordon | 199 | 194 | 5 |
| 2001-05-23 | vs CIN | 45 | W 4-2 | 25-20 | 2 | 25,966 | Jason Bere | Rob Bell | Todd Van Poppel | Rob Bell | Tom Gordon | 203 | 196 | 7 |
| 2001-05-24 | vs CIN | 46 | W 3-0 | 26-20 | 2 | 26,227 | Jon Lieber | Osvaldo Fernandez | Jon Lieber | Osvaldo Fernandez | | 206 | 196 | 10 |
| 2001-05-25 | vs MIL | 47 | W 1-0 | 27-20 | 2 | 26,526 | Kerry Wood | Allen Levrault | Kerry Wood | Allen Levrault | | 207 | 196 | 11 |
| 2001-05-27 | vs MIL | 48 | W 4-1 | 28-20 | 1 | 39,095 | Kevin Tapani | Jimmy Haynes | Kevin Tapani | Jimmy Haynes | Tom Gordon | 211 | 197 | 14 |
| 2001-05-28 | @ CIN | 49 | W 9-6 | 29-20 | 1 | 24,359 | Julian Tavarez | Rob Bell | Courtney Duncan | Scott Winchester | | 220 | 203 | 17 |
| 2001-05-29 | @ CIN | 50 | W 10-5 | 30-20 | 1 | 18,837 | Jason Bere | Osvaldo Fernandez | Jason Bere | Osvaldo Fernandez | | 230 | 208 | 22 |
| 2001-05-30 | @ CIN | 51 | W 3-1 | 31-20 | 1 | 20,062 | Jon Lieber | Chris Reitsma | Jon Lieber | Chris Reitsma | Tom Gordon | 233 | 209 | 24 |
| 2001-06-01 | @ MIL | 52 | W 4-3 | 32-20 | 1 | 42,392 | Kerry Wood | Jimmy Haynes | Kerry Wood | Jimmy Haynes | Tom Gordon | 237 | 212 | 25 |
| 2001-06-02 | @ MIL | 53 | W 10-4 | 33-20 | 1 | 43,400 | Kevin Tapani | Paul Rigdon | Kevin Tapani | Paul Rigdon | | 247 | 216 | 31 |
| 2001-06-03 | @ MIL | 54 | L 2-4 | 33-21 | 1 | 42,385 | Julian Tavarez | Ben Sheets | Ben Sheets | Julian Tavarez | Curt Leskanic | 249 | 220 | 29 |
| 2001-06-05 | vs SLN | 55 | W 12-6 | 34-21 | 1 | 37,912 | Jon Lieber | Dustin Hermanson | Jon Lieber | Dustin Hermanson | | 261 | 226 | 35 |
| 2001-06-06 | vs SLN | 56 | W 4-1 | 35-21 | 1 | 34,484 | Kerry Wood | Darryl Kile | Kerry Wood | Darryl Kile | Tom Gordon | 265 | 227 | 38 |
| 2001-06-07 | vs SLN | 57 | W 4-3 | 36-21 | 1 | 37,359 | Kevin Tapani | Matt Morris | Jeff Fassero | Mike Timlin | | 269 | 230 | 39 |
| 2001-06-08 | @ CHA | 58 | L 3-7 | 36-22 | 1 | 45,936 | Jason Bere | David Wells | Keith Foulke | Courtney Duncan | | 272 | 237 | 35 |
| 2001-06-09 | @ CHA | 59 | W 4-3 | 37-22 | 1 | 45,849 | Julian Tavarez | Rocky Biddle | Todd Van Poppel | Keith Foulke | Jeff Fassero | 276 | 240 | 36 |
| 2001-06-10 | @ CHA | 60 | L 1-3 | 37-23 | 1 | 45,079 | Jon Lieber | Kip Wells | Kip Wells | Jon Lieber | Bob Howry | 277 | 243 | 34 |
| 2001-06-12 | @ ARI | 61 | W 6-2 | 38-23 | 1 | 40,191 | Kerry Wood | Curt Schilling | Kerry Wood | Curt Schilling | | 283 | 245 | 38 |
| 2001-06-13 | @ ARI | 62 | L 3-13 | 38-24 | 1 | 33,670 | Kevin Tapani | Nick Bierbrodt | Nick Bierbrodt | Kevin Tapani | | 286 | 258 | 28 |
| 2001-06-14 | @ ARI | 63 | L 2-3 | 38-25 | 1 | 40,093 | Jason Bere | Randy Johnson | Randy Johnson | Jason Bere | Greg Swindell | 288 | 261 | 27 |
| 2001-06-15 | vs MIN | 64 | W 5-3 | 39-25 | 1 | 39,637 | Julian Tavarez | J.C. Romero | Julian Tavarez | J.C. Romero | Tom Gordon | 293 | 264 | 29 |
| 2001-06-16 | vs MIN | 65 | W 11-4 | 40-25 | 1 | 40,604 | Jon Lieber | Brad Thomas | Jon Lieber | Brad Thomas | | 304 | 268 | 36 |
| 2001-06-17 | vs MIN | 66 | W 5-4 | 41-25 | 1 | 39,700 | Kerry Wood | Brad Radke | Kerry Wood | Brad Radke | Tom Gordon | 309 | 272 | 37 |
| 2001-06-18 | @ SLN | 67 | L 2-6 | 41-26 | 1 | 40,016 | Kevin Tapani | Darryl Kile | Darryl Kile | Kevin Tapani | | 311 | 278 | 33 |
| 2001-06-19 | @ SLN | 68 | L 2-3 | 41-27 | 1 | 40,715 | Jason Bere | Matt Morris | Matt Morris | Kyle Farnsworth | Dave Veres | 313 | 281 | 32 |
| 2001-06-20 | @ SLN | 69 | W 9-4 | 42-27 | 1 | 41,968 | Julian Tavarez | Mike Matthews | Julian Tavarez | Mike Matthews | | 322 | 285 | 37 |
| 2001-06-21 | @ SLN | 70 | W 5-2 | 43-27 | 1 | 47,950 | Jon Lieber | Andy Benes | Jon Lieber | Andy Benes | Tom Gordon | 327 | 287 | 40 |
| 2001-06-22 | vs MIL | 71 | L 1-2 | 43-28 | 1 | 39,703 | Kerry Wood | Jimmy Haynes | David Weathers | Kerry Wood | Curt Leskanic | 328 | 289 | 39 |
| 2001-06-23 | vs MIL | 72 | L 0-4 | 43-29 | 1 | 40,460 | Kevin Tapani | Jamey Wright | Jamey Wright | Kevin Tapani | | 328 | 293 | 35 |
| 2001-06-24 | vs MIL | 73 | L 3-6 | 43-30 | 1 | 38,501 | Jason Bere | Ben Sheets | Ben Sheets | Jason Bere | Curt Leskanic | 331 | 299 | 32 |
| 2001-06-25 | vs NYN | 74 | W 2-1 | 44-30 | 1 | 40,229 | Julian Tavarez | Al Leiter | Julian Tavarez | Al Leiter | Tom Gordon | 333 | 300 | 33 |
| 2001-06-26 | vs NYN | 75 | W 4-2 | 45-30 | 1 | 37,854 | Jon Lieber | Kevin Appier | Jon Lieber | Kevin Appier | Tom Gordon | 337 | 302 | 35 |
| 2001-06-27 | vs NYN | 76 | L 4-5 | 45-31 | 1 | 39,404 | Kerry Wood | Rick Reed | Rick White | Kyle Farnsworth | Armando Benitez | 341 | 307 | 34 |
| 2001-06-28 | @ CIN | 77 | L 2-5 | 45-32 | 1 | 25,417 | Kevin Tapani | Elmer Dessens | Elmer Dessens | Kevin Tapani | | 343 | 312 | 31 |
| 2001-06-29 | @ CIN | 78 | W 7-1 | 46-32 | 1 | 30,719 | Jason Bere | Brian Reith | Jason Bere | Brian Reith | | 350 | 313 | 37 |
| 2001-06-30 | @ CIN | 79 | L 1-7 | 46-33 | 1 | 32,547 | Julian Tavarez | Jose Acevedo | Jose Acevedo | Julian Tavarez | | 351 | 320 | 31 |
| 2001-07-01 | @ CIN | 80 | W 2-1 | 47-33 | 1 | 28,033 | Jon Lieber | Chris Reitsma | Jon Lieber | Chris Reitsma | Tom Gordon | 353 | 321 | 32 |
| 2001-07-03 | @ NYN | 81 | W 3-0 | 48-33 | 1 | 52,471 | Kerry Wood | Rick Reed | Kerry Wood | Rick Reed | Tom Gordon | 356 | 321 | 35 |
| 2001-07-04 | @ NYN | 82 | L 1-2 | 48-34 | 1 | 37,936 | Kevin Tapani | Glendon Rusch | Glendon Rusch | Kevin Tapani | Armando Benitez | 357 | 323 | 34 |
| 2001-07-05 | @ NYN | 83 | W 13-4 | 49-34 | 1 | 30,737 | Jason Bere | Steve Trachsel | Jason Bere | Steve Trachsel | | 370 | 327 | 43 |
| 2001-07-06 | @ DET | 84 | W 15-9 | 50-34 | 1 | 39,906 | Julian Tavarez | Chris Holt | Felix Heredia | C.J. Nitkowski | | 385 | 336 | 49 |
| 2001-07-07 | @ DET | 85 | W 10-6 | 51-34 | 1 | 39,697 | Jon Lieber | Willie Blair | Jon Lieber | Willie Blair | | 395 | 342 | 53 |
| 2001-07-08 | @ DET | 86 | L 6-9 | 51-35 | 1 | 38,729 | Kerry Wood | Jose Lima | Todd Jones | Felix Heredia | Matt Anderson | 401 | 351 | 50 |
| 2001-07-12 | vs CHA | 87 | W 5-1 | 52-35 | 1 | 38,233 | Jason Bere | Kip Wells | Jeff Fassero | Jon Garland | | 406 | 352 | 54 |
| 2001-07-13 | vs CHA | 88 | L 2-7 | 52-36 | 1 | 40,157 | Kerry Wood | Mark Buehrle | Mark Buehrle | Kerry Wood | | 408 | 359 | 49 |
| 2001-07-14 | vs CHA | 89 | L 1-3 | 52-37 | 1 | 40,551 | Julian Tavarez | Sean Lowe | Sean Lowe | Julian Tavarez | Keith Foulke | 409 | 362 | 47 |
| 2001-07-15 | vs KCA | 90 | W 2-1 | 53-37 | 1 | 39,183 | Jon Lieber | Paul Byrd | Jon Lieber | Paul Byrd | Tom Gordon | 411 | 363 | 48 |
| 2001-07-16 | vs KCA | 91 | L 2-4 | 53-38 | 1 | 39,769 | Kevin Tapani | Dan Reichert | Dan Reichert | Kevin Tapani | Roberto Hernandez | 413 | 367 | 46 |
| 2001-07-17 | vs KCA | 92 | W 7-4 | 54-38 | 1 | 38,013 | Jason Bere | Jeff Suppan | Jason Bere | Tony Cogan | Tom Gordon | 420 | 371 | 49 |
| 2001-07-18 | @ PIT | 93 | W 6-5 | 55-38 | 1 | 31,919 | Kerry Wood | Todd Ritchie | Jeff Fassero | Mike Williams | Tom Gordon | 426 | 376 | 50 |
| 2001-07-19 | @ PIT | 94 | L 2-3 | 55-39 | 1 | 34,921 | Julian Tavarez | David Williams | Omar Olivares | Courtney Duncan | Mike Williams | 428 | 379 | 49 |
| 2001-07-20 | @ HOU | 95 | L 2-5 | 55-40 | 1 | 43,163 | Jon Lieber | Tim Redding | Tim Redding | Jon Lieber | Billy Wagner | 430 | 384 | 46 |
| 2001-07-21 | @ HOU | 96 | W 5-4 | 56-40 | 1 | 43,208 | Kevin Tapani | Dave Mlicki | Kyle Farnsworth | Ron Villone | Tom Gordon | 435 | 388 | 47 |
| 2001-07-22 | @ HOU | 97 | L 0-3 | 56-41 | 1 | 43,011 | Jason Bere | Shane Reynolds | Shane Reynolds | Jason Bere | Billy Wagner | 435 | 391 | 44 |
| 2001-07-23 | @ HOU | 98 | W 6-2 | 57-41 | 1 | 42,958 | Kerry Wood | Roy Oswalt | Kerry Wood | Roy Oswalt | | 441 | 393 | 48 |
| 2001-07-24 | vs PIT | 99 | W 10-2 | 58-41 | 1 | 40,269 | Julian Tavarez | Todd Ritchie | Julian Tavarez | Todd Ritchie | | 451 | 395 | 56 |
| 2001-07-25 | vs PIT | 100 | W 6-5 | 59-41 | 1 | 38,508 | Jon Lieber | David Williams | Jon Lieber | David Williams | | 457 | 400 | 57 |
| 2001-07-26 | vs SLN | 101 | L 1-3 | 59-42 | 1 | 38,549 | Kevin Tapani | Bud Smith | Bud Smith | Kevin Tapani | Steve Kline | 458 | 403 | 55 |
| 2001-07-27 | vs SLN | 102 | W 4-3 | 60-42 | 1 | 40,125 | Jason Bere | Darryl Kile | Jeff Fassero | Jason Christiansen | Tom Gordon | 462 | 406 | 56 |
| 2001-07-28 | vs SLN | 103 | L 4-7 | 60-43 | 1 | 40,266 | Kerry Wood | Andy Benes | Dave Veres | Mike Fyhrie | Steve Kline | 466 | 413 | 53 |
| 2001-07-29 | vs SLN | 104 | W 7-5 | 61-43 | 1 | 40,295 | Julian Tavarez | Matt Morris | Julian Tavarez | Matt Morris | Tom Gordon | 473 | 418 | 55 |
| 2001-07-31 | @ SDN | 105 | W 7-3 | 62-43 | 1 | 25,358 | Jon Lieber | Brian Lawrence | Jon Lieber | Brian Lawrence | | 480 | 421 | 59 |
| 2001-08-01 | @ SDN | 106 | L 3-4 | 62-44 | 1 | 24,115 | Kevin Tapani | Bobby Jones | Bobby Jones | Felix Heredia | Trevor Hoffman | 483 | 425 | 58 |
| 2001-08-02 | @ SDN | 107 | L 3-4 | 62-45 | 1 | 25,043 | Jason Bere | Junior Herndon | Chuck McElroy | Jeff Fassero | Trevor Hoffman | 486 | 429 | 57 |
| 2001-08-03 | @ LAN | 108 | W 2-1 | 63-45 | 1 | 52,118 | Kerry Wood | Chan Ho Park | Kerry Wood | Chan Ho Park | Tom Gordon | 488 | 430 | 58 |
| 2001-08-04 | @ LAN | 109 | L 1-3 | 63-46 | 1 | 47,311 | Julian Tavarez | James Baldwin | James Baldwin | Julian Tavarez | Jeff Shaw | 489 | 433 | 56 |
| 2001-08-05 | @ LAN | 110 | L 2-3 | 63-47 | 1 | 51,327 | Jon Lieber | Eric Gagne | Terry Mulholland | Tom Gordon | | 491 | 436 | 55 |
| 2001-08-07 | vs COL | 111 | W 5-4 | 64-47 | 1 | 40,266 | Kevin Tapani | Denny Neagle | Kyle Farnsworth | Justin Speier | | 496 | 440 | 56 |
| 2001-08-08 | vs COL | 112 | W 2-1 | 65-47 | 1 | 38,801 | Jason Bere | John Thomson | Jason Bere | John Thomson | Tom Gordon | 498 | 441 | 57 |
| 2001-08-09 | vs COL | 113 | L 5-14 | 65-48 | 1 | 38,345 | Julian Tavarez | Mike Hampton | Mike Hampton | Julian Tavarez | | 503 | 455 | 48 |
| 2001-08-10 | vs SFN | 114 | W 9-3 | 66-48 | 1 | 40,529 | Jon Lieber | Shawn Estes | Jon Lieber | Shawn Estes | | 512 | 458 | 54 |
| 2001-08-11 | vs SFN | 115 | L 4-9 | 66-49 | 1 | 40,541 | Joe Borowski | Livan Hernandez | Livan Hernandez | Joe Borowski | | 516 | 467 | 49 |
| 2001-08-12 | vs SFN | 116 | L 6-7 | 66-50 | 1 | 40,314 | Kevin Tapani | Kirk Rueter | Kirk Rueter | Kevin Tapani | Robb Nen | 522 | 474 | 48 |
| 2001-08-13 | @ HOU | 117 | L 5-9 | 66-51 | 2 | 39,056 | Jason Bere | Shane Reynolds | Shane Reynolds | Jason Bere | | 527 | 483 | 44 |
| 2001-08-14 | @ HOU | 118 | W 3-1 | 67-51 | 1 | 40,055 | Julian Tavarez | Roy Oswalt | David Weathers | Ron Villone | Tom Gordon | 530 | 484 | 46 |
| 2001-08-15 | @ HOU | 119 | W 5-1 | 68-51 | 1 | 41,469 | Jon Lieber | Pedro Astacio | Jon Lieber | Pedro Astacio | | 535 | 485 | 50 |
| 2001-08-17 | @ ARI | 120 | L 2-7 | 68-52 | 1 | 42,667 | Kevin Tapani | Albie Lopez | Albie Lopez | Kevin Tapani | Byung-Hyun Kim | 537 | 492 | 45 |
| 2001-08-18 | @ ARI | 121 | L 3-5 | 68-53 | 2 | 47,489 | Jason Bere | Randy Johnson | Randy Johnson | Jason Bere | Byung-Hyun Kim | 540 | 497 | 43 |
| 2001-08-19 | @ ARI | 122 | L 6-13 | 68-54 | 2 | 44,449 | Julian Tavarez | Brian Anderson | Bobby Witt | Will Ohman | | 546 | 510 | 36 |
| 2001-08-20 | vs MIL | 123 | W 7-4 | 69-55 | 2 | 0 | Jon Lieber | Allen Levrault | Kyle Farnsworth | Ray King | Tom Gordon | 553 | 514 | 39 |
| 2001-08-20 | vs MIL | 124 | L 2-10 | 69-55 | 2 | 40,657 | Carlos Zambrano | Jamey Wright | Jamey Wright | Carlos Zambrano | | 555 | 524 | 31 |
| 2001-08-21 | vs MIL | 125 | L 1-3 | 69-56 | 2 | 35,599 | Juan Cruz | Ruben Quevedo | Ruben Quevedo | Juan Cruz | Curt Leskanic | 556 | 527 | 29 |
| 2001-08-22 | vs MIL | 126 | W 16-3 | 70-56 | 2 | 33,904 | Kevin Tapani | Mac Suzuki | Kevin Tapani | Mac Suzuki | | 572 | 530 | 42 |
| 2001-08-23 | vs MIL | 127 | L 1-8 | 70-57 | 2 | 35,064 | Julian Tavarez | Jimmy Haynes | Mac Suzuki | Julian Tavarez | | 573 | 538 | 35 |
| 2001-08-24 | vs SLN | 128 | L 8-10 | 70-58 | 2 | 39,357 | Jason Bere | Matt Morris | Matt Morris | Jason Bere | Luther Hackman | 581 | 548 | 33 |
| 2001-08-25 | vs SLN | 129 | W 6-4 | 71-58 | 2 | 38,504 | Jon Lieber | Woody Williams | Jon Lieber | Woody Williams | Tom Gordon | 587 | 552 | 35 |
| 2001-08-26 | vs SLN | 130 | W 6-1 | 72-58 | 2 | 39,045 | Juan Cruz | Dustin Hermanson | Juan Cruz | Dustin Hermanson | | 593 | 553 | 40 |
| 2001-08-28 | vs FLO | 131 | L 3-4 | 72-59 | 2 | 38,744 | Kevin Tapani | Ryan Dempster | Vladimir Nunez | Jeff Fassero | | 596 | 557 | 39 |
| 2001-08-29 | vs FLO | 132 | W 5-1 | 73-59 | 2 | 37,437 | Jason Bere | Matt Clement | Jason Bere | Matt Clement | | 601 | 558 | 43 |
| 2001-08-30 | vs FLO | 133 | W 5-4 | 74-59 | 2 | 29,130 | Jon Lieber | Jesus Sanchez | Kyle Farnsworth | Ricky Bones | | 606 | 562 | 44 |
| 2001-08-31 | @ ATL | 134 | W 8-2 | 75-59 | 2 | 37,045 | Juan Cruz | John Burkett | Juan Cruz | John Burkett | | 614 | 564 | 50 |
| 2001-09-01 | @ ATL | 135 | W 5-3 | 76-59 | 2 | 45,842 | Julian Tavarez | Greg Maddux | Julian Tavarez | Greg Maddux | Tom Gordon | 619 | 567 | 52 |
| 2001-09-02 | @ ATL | 136 | L 4-7 | 76-60 | 2 | 45,165 | Kevin Tapani | Kevin Millwood | Kevin Millwood | Kevin Tapani | John Smoltz | 623 | 574 | 49 |
| 2001-09-03 | @ FLO | 137 | W 10-2 | 77-60 | 2 | 20,390 | Jason Bere | Matt Clement | Jason Bere | Matt Clement | | 633 | 576 | 57 |
| 2001-09-04 | @ FLO | 138 | L 1-8 | 77-61 | 2 | 13,401 | Jon Lieber | Josh Beckett | Josh Beckett | Jon Lieber | | 634 | 584 | 50 |
| 2001-09-05 | @ FLO | 139 | L 6-7 | 77-62 | 2 | 13,221 | Juan Cruz | Jesus Sanchez | Armando Almanza | Tom Gordon | | 640 | 591 | 49 |
| 2001-09-07 | vs ATL | 140 | L 2-3 | 77-63 | 2 | 37,710 | Kerry Wood | Greg Maddux | Steve Karsay | Kyle Farnsworth | John Smoltz | 642 | 594 | 48 |
| 2001-09-08 | vs ATL | 141 | L 3-5 | 77-64 | 2 | 38,705 | Kevin Tapani | Tom Glavine | Tom Glavine | Kevin Tapani | John Smoltz | 645 | 599 | 46 |
| 2001-09-09 | vs ATL | 142 | L 5-9 | 77-65 | 3 | 37,213 | Jason Bere | Kevin Millwood | Kerry Ligtenberg | Jason Bere | | 650 | 608 | 42 |
| 2001-09-10 | vs CIN | 143 | W 8-2 | 78-65 | 3 | 35,159 | Jon Lieber | Chris Reitsma | Jon Lieber | Chris Reitsma | | 658 | 610 | 48 |
| 2001-09-18 | @ CIN | 144 | L 5-6 | 78-66 | 3 | 21,304 | Jon Lieber | Elmer Dessens | Danny Graves | Kyle Farnsworth | | 663 | 616 | 47 |
| 2001-09-19 | @ CIN | 145 | W 10-0 | 79-66 | 3 | 18,417 | Kerry Wood | Joey Hamilton | Kerry Wood | Joey Hamilton | | 673 | 616 | 57 |
| 2001-09-20 | @ CIN | 146 | W 6-5 | 80-66 | 3 | 19,947 | Jason Bere | Jim Brower | Jason Bere | Jim Brower | Jeff Fassero | 679 | 621 | 58 |
| 2001-09-21 | @ HOU | 147 | W 12-4 | 81-66 | 3 | 42,621 | Juan Cruz | Ron Villone | Carlos Zambrano | Ron Villone | | 691 | 625 | 66 |
| 2001-09-22 | @ HOU | 148 | L 4-8 | 81-67 | 3 | 43,167 | Kevin Tapani | Shane Reynolds | Shane Reynolds | Kevin Tapani | | 695 | 633 | 62 |
| 2001-09-23 | @ HOU | 149 | L 6-7 | 81-68 | 3 | 43,057 | Jon Lieber | Tim Redding | Mike Williams | David Weathers | Billy Wagner | 701 | 640 | 61 |
| 2001-09-24 | @ PIT | 150 | L 6-7 | 81-69 | 3 | 18,908 | Kerry Wood | Tony McKnight | Mike Lincoln | Scott Chiasson | Rich Loiselle | 707 | 647 | 60 |
| 2001-09-25 | @ PIT | 151 | L 1-13 | 81-70 | 3 | 18,581 | Jason Bere | Jimmy Anderson | Jimmy Anderson | Jason Bere | | 708 | 660 | 48 |
| 2001-09-26 | @ PIT | 152 | W 8-4 | 82-70 | 3 | 25,564 | Juan Cruz | Bronson Arroyo | Juan Cruz | Bronson Arroyo | | 716 | 664 | 52 |
| 2001-09-27 | vs HOU | 153 | L 5-6 | 82-71 | 3 | 38,154 | Kevin Tapani | Shane Reynolds | Shane Reynolds | Kevin Tapani | Billy Wagner | 721 | 670 | 51 |
| 2001-09-28 | vs HOU | 154 | W 6-2 | 83-71 | 3 | 36,573 | Jon Lieber | Roy Oswalt | Jon Lieber | Roy Oswalt | | 727 | 672 | 55 |
| 2001-09-29 | vs HOU | 155 | W 6-2 | 84-71 | 3 | 37,641 | Kerry Wood | Dave Mlicki | Kerry Wood | Dave Mlicki | | 733 | 674 | 59 |
| 2001-09-30 | vs HOU | 156 | W 7-6 | 85-71 | 3 | 38,438 | Jason Bere | Wade Miller | Scott Chiasson | Ron Villone | Kyle Farnsworth | 740 | 680 | 60 |
| 2001-10-02 | vs CIN | 157 | L 4-5 | 85-72 | 3 | 35,220 | Juan Cruz | Lance Davis | Scott Sullivan | Kyle Farnsworth | Danny Graves | 744 | 685 | 59 |
| 2001-10-03 | vs CIN | 158 | W 13-7 | 86-72 | 3 | 22,712 | Jon Lieber | Jared Fernandez | Jon Lieber | Scott MacRae | | 757 | 692 | 65 |
| 2001-10-04 | vs CIN | 159 | W 2-0 | 87-72 | 3 | 19,535 | Kerry Wood | Jose Acevedo | Todd Van Poppel | Jose Acevedo | Kyle Farnsworth | 759 | 692 | 67 |
| 2001-10-05 | vs PIT | 160 | L 2-3 | 87-73 | 3 | 24,786 | Jason Bere | David Williams | Joe Beimel | Jason Bere | Mike Fetters | 761 | 695 | 66 |
| 2001-10-06 | vs PIT | 161 | W 13-2 | 88-73 | 3 | 35,020 | Julian Tavarez | Tony McKnight | Julian Tavarez | Tony McKnight | | 774 | 697 | 77 |
| 2001-10-07 | vs PIT | 162 | L 3-4 | 88-74 | 3 | 35,083 | Juan Cruz | Jimmy Anderson | Joe Beimel | Carlos Zambrano | Mike Fetters | 777 | 701 | 76 |