| 2001-04-02 | vs BOS | 1 | W 2-1 | 1-0 | 1 | 46,547 | Pat Hentgen | Pedro Martinez | Ryan Kohlmeier | Derek Lowe | | 2 | 1 | 1 |
| 2001-04-04 | vs BOS | 2 | L 0-3 | 1-1 | 3 | 35,602 | Sidney Ponson | Hideo Nomo | Hideo Nomo | Sidney Ponson | | 2 | 4 | -2 |
| 2001-04-05 | vs BOS | 3 | W 2-1 | 2-1 | 3 | 33,469 | Jason Johnson | Frank Castillo | Buddy Groom | Derek Lowe | | 4 | 5 | -1 |
| 2001-04-06 | @ CLE | 4 | L 3-4 | 2-2 | 3 | 32,738 | Jose Mercedes | Dave Burba | Ricardo Rincon | Jose Mercedes | Bob Wickman | 7 | 9 | -2 |
| 2001-04-07 | @ CLE | 5 | W 4-2 | 3-2 | 2 | 40,704 | Pat Hentgen | Bartolo Colon | Mike Trombley | Steve Reed | Ryan Kohlmeier | 11 | 11 | 0 |
| 2001-04-08 | @ CLE | 6 | L 3-4 | 3-3 | 4 | 40,754 | Chuck McElroy | CC Sabathia | Justin Speier | Calvin Maduro | Bob Wickman | 14 | 15 | -1 |
| 2001-04-10 | @ BOS | 7 | L 1-10 | 3-4 | 4 | 27,664 | Sidney Ponson | Hideo Nomo | Hideo Nomo | Sidney Ponson | Tim Wakefield | 15 | 25 | -10 |
| 2001-04-11 | @ BOS | 8 | W 5-4 | 4-4 | 4 | 26,302 | Jason Johnson | Frank Castillo | Willis Roberts | Frank Castillo | Buddy Groom | 20 | 29 | -9 |
| 2001-04-12 | @ BOS | 9 | L 2-8 | 4-5 | 4 | 30,083 | Jose Mercedes | Tomo Ohka | Tomo Ohka | Jose Mercedes | Rolando Arrojo | 22 | 37 | -15 |
| 2001-04-13 | vs TBA | 10 | L 0-2 | 4-6 | 4 | 34,656 | Pat Hentgen | Albie Lopez | Albie Lopez | Pat Hentgen | | 22 | 39 | -17 |
| 2001-04-14 | vs TBA | 11 | W 6-5 | 5-6 | 4 | 43,621 | Chuck McElroy | Paul Wilson | John Bale | Rusty Meacham | Ryan Kohlmeier | 28 | 44 | -16 |
| 2001-04-15 | vs TBA | 12 | L 4-7 | 5-7 | 4 | 30,441 | Sidney Ponson | Bryan Rekar | Doug Creek | Sidney Ponson | Esteban Yan | 32 | 51 | -19 |
| 2001-04-16 | vs TBA | 13 | W 6-2 | 6-7 | 4 | 24,558 | Jason Johnson | Ryan Rupe | Jason Johnson | Ryan Rupe | | 38 | 53 | -15 |
| 2001-04-17 | vs CLE | 14 | L 1-8 | 6-8 | 4 | 28,679 | Jose Mercedes | Dave Burba | Dave Burba | Jose Mercedes | | 39 | 61 | -22 |
| 2001-04-18 | vs CLE | 15 | L 1-4 | 6-9 | 4 | 28,801 | Pat Hentgen | Bartolo Colon | Bartolo Colon | Pat Hentgen | | 40 | 65 | -25 |
| 2001-04-19 | vs CLE | 16 | L 5-11 | 6-10 | 4 | 34,100 | Chuck McElroy | CC Sabathia | CC Sabathia | Chuck McElroy | | 45 | 76 | -31 |
| 2001-04-20 | @ TBA | 17 | W 6-3 | 7-10 | 4 | 13,013 | Willis Roberts | Bryan Rekar | Willis Roberts | Bryan Rekar | Ryan Kohlmeier | 51 | 79 | -28 |
| 2001-04-21 | @ TBA | 18 | L 5-6 | 7-11 | 4 | 14,026 | Jason Johnson | Ryan Rupe | Ryan Rupe | Jason Johnson | Esteban Yan | 56 | 85 | -29 |
| 2001-04-22 | @ TBA | 19 | W 10-8 | 8-11 | 4 | 18,934 | Jose Mercedes | Mike Judd | Chad Paronto | Esteban Yan | | 66 | 93 | -27 |
| 2001-04-24 | @ DET | 20 | W 8-3 | 9-11 | 4 | 14,101 | Pat Hentgen | Jeff Weaver | Pat Hentgen | Jeff Weaver | | 74 | 96 | -22 |
| 2001-04-25 | @ DET | 21 | W 6-4 | 10-11 | 4 | 18,919 | Willis Roberts | Steve Sparks | Willis Roberts | Steve Sparks | Ryan Kohlmeier | 80 | 100 | -20 |
| 2001-04-26 | @ DET | 22 | L 2-8 | 10-12 | 4 | 18,824 | Jason Johnson | Chris Holt | Chris Holt | Jason Johnson | | 82 | 108 | -26 |
| 2001-04-27 | @ MIN | 23 | L 3-6 | 10-13 | 4 | 24,369 | Jose Mercedes | Joe Mays | Joe Mays | Jose Mercedes | LaTroy Hawkins | 85 | 114 | -29 |
| 2001-04-28 | @ MIN | 24 | W 5-2 | 11-13 | 4 | 30,479 | Chuck McElroy | Mark Redman | Chuck McElroy | Mark Redman | Mike Trombley | 90 | 116 | -26 |
| 2001-04-29 | @ MIN | 25 | L 0-4 | 11-14 | 4 | 23,011 | Pat Hentgen | J.C. Romero | J.C. Romero | Pat Hentgen | LaTroy Hawkins | 90 | 120 | -30 |
| 2001-04-30 | vs TBA | 26 | W 5-3 | 12-14 | 4 | 28,510 | Willis Roberts | Paul Wilson | Willis Roberts | Paul Wilson | Ryan Kohlmeier | 95 | 123 | -28 |
| 2001-05-01 | vs TBA | 27 | W 3-1 | 13-14 | 4 | 27,208 | Jason Johnson | Bryan Rekar | Jason Johnson | Bryan Rekar | Ryan Kohlmeier | 98 | 124 | -26 |
| 2001-05-02 | vs TBA | 28 | L 1-7 | 13-15 | 4 | 26,615 | Jose Mercedes | Ryan Rupe | Ryan Rupe | Jose Mercedes | Tanyon Sturtze | 99 | 131 | -32 |
| 2001-05-03 | vs NYA | 29 | L 5-7 | 13-16 | 4 | 40,218 | Chuck McElroy | Ted Lilly | Ramiro Mendoza | Chad Paronto | Mariano Rivera | 104 | 138 | -34 |
| 2001-05-04 | vs NYA | 30 | L 5-6 | 13-17 | 4 | 43,133 | Pat Hentgen | Roger Clemens | Mike Stanton | Chad Paronto | Mariano Rivera | 109 | 144 | -35 |
| 2001-05-05 | vs NYA | 31 | L 2-5 | 13-18 | 4 | 47,726 | Willis Roberts | Andy Pettitte | Andy Pettitte | Willis Roberts | Brian Boehringer | 111 | 149 | -38 |
| 2001-05-06 | vs NYA | 32 | L 1-2 | 13-19 | 4 | 47,740 | Jason Johnson | Mike Mussina | Mike Mussina | Mike Trombley | Mariano Rivera | 112 | 151 | -39 |
| 2001-05-08 | @ TBA | 33 | L 3-4 | 13-20 | 4 | 11,078 | Jose Mercedes | Tanyon Sturtze | Rusty Meacham | Jose Mercedes | Esteban Yan | 115 | 155 | -40 |
| 2001-05-09 | @ TBA | 34 | W 8-6 | 14-20 | 4 | 11,108 | Sidney Ponson | Albie Lopez | Josh Towers | Ryan Rupe | Mike Trombley | 123 | 161 | -38 |
| 2001-05-10 | @ TBA | 35 | W 9-5 | 15-20 | 4 | 11,089 | Pat Hentgen | Paul Wilson | B.J. Ryan | Rusty Meacham | | 132 | 166 | -34 |
| 2001-05-11 | @ NYA | 36 | L 5-14 | 15-21 | 4 | 40,433 | Willis Roberts | Mike Mussina | Mike Mussina | Willis Roberts | Ramiro Mendoza | 137 | 180 | -43 |
| 2001-05-12 | @ NYA | 37 | L 5-8 | 15-22 | 4 | 48,288 | Jason Johnson | Ted Lilly | Mike Stanton | Josh Towers | Mariano Rivera | 142 | 188 | -46 |
| 2001-05-13 | @ NYA | 38 | W 10-5 | 16-22 | 4 | 39,819 | Jose Mercedes | Orlando Hernandez | B.J. Ryan | Mariano Rivera | | 152 | 193 | -41 |
| 2001-05-15 | vs DET | 39 | W 11-3 | 17-22 | 4 | 33,853 | Sidney Ponson | Dave Mlicki | Sidney Ponson | Dave Mlicki | | 163 | 196 | -33 |
| 2001-05-16 | vs DET | 40 | W 3-2 | 18-22 | 4 | 27,722 | Pat Hentgen | Jeff Weaver | Pat Hentgen | Jeff Weaver | B.J. Ryan | 166 | 198 | -32 |
| 2001-05-17 | vs DET | 41 | L 5-7 | 18-23 | 4 | 27,508 | Willis Roberts | Steve Sparks | Steve Sparks | Willis Roberts | Todd Jones | 171 | 205 | -34 |
| 2001-05-18 | vs MIN | 42 | W 7-2 | 19-23 | 4 | 38,558 | Jason Johnson | Eric Milton | Jason Johnson | Eric Milton | | 178 | 207 | -29 |
| 2001-05-19 | vs MIN | 43 | L 5-7 | 19-24 | 4 | 40,041 | Jose Mercedes | Joe Mays | Joe Mays | B.J. Ryan | LaTroy Hawkins | 183 | 214 | -31 |
| 2001-05-20 | vs MIN | 44 | W 3-2 | 20-24 | 4 | 41,959 | Sidney Ponson | Mark Redman | Mike Trombley | Bob Wells | | 186 | 216 | -30 |
| 2001-05-23 | vs ANA | 45 | W 12-5 | 21-24 | 4 | 31,249 | Willis Roberts | Scott Schoeneweis | Willis Roberts | Scott Schoeneweis | | 198 | 221 | -23 |
| 2001-05-24 | vs ANA | 46 | W 6-4 | 22-24 | 4 | 34,555 | Jason Johnson | Ramon Ortiz | Jason Johnson | Ramon Ortiz | B.J. Ryan | 204 | 225 | -21 |
| 2001-05-25 | vs TEX | 47 | W 7-6 | 23-24 | 4 | 33,117 | Jose Mercedes | Pat Mahomes | Jose Mercedes | Pat Mahomes | Mike Trombley | 211 | 231 | -20 |
| 2001-05-27 | vs TEX | 48 | W 3-1 | 24-24 | 4 | 39,426 | Sidney Ponson | Ryan Glynn | Sidney Ponson | Ryan Glynn | Mike Trombley | 214 | 232 | -18 |
| 2001-05-28 | vs TEX | 49 | L 3-6 | 24-25 | 4 | 37,090 | Josh Towers | Kenny Rogers | J.D. Smart | Chad Paronto | | 217 | 238 | -21 |
| 2001-05-29 | @ SEA | 50 | L 2-3 | 24-26 | 4 | 30,413 | Willis Roberts | Freddy Garcia | Freddy Garcia | Willis Roberts | Kazuhiro Sasaki | 219 | 241 | -22 |
| 2001-05-30 | @ SEA | 51 | L 5-12 | 24-27 | 4 | 34,757 | Jason Johnson | John Halama | John Halama | Jason Johnson | | 224 | 253 | -29 |
| 2001-05-31 | @ SEA | 52 | L 1-2 | 24-28 | 4 | 37,612 | Jose Mercedes | Aaron Sele | Aaron Sele | Jose Mercedes | Kazuhiro Sasaki | 225 | 255 | -30 |
| 2001-06-01 | @ OAK | 53 | W 8-4 | 25-28 | 4 | 30,168 | Sidney Ponson | Gil Heredia | Sidney Ponson | Jim Mecir | | 233 | 259 | -26 |
| 2001-06-02 | @ OAK | 54 | W 7-0 | 26-28 | 3 | 23,726 | Josh Towers | Barry Zito | Josh Towers | Barry Zito | | 240 | 259 | -19 |
| 2001-06-03 | @ OAK | 55 | L 1-5 | 26-29 | 3 | 18,977 | Willis Roberts | Cory Lidle | Cory Lidle | Willis Roberts | | 241 | 264 | -23 |
| 2001-06-05 | @ NYA | 56 | W 10-3 | 27-29 | 3 | 30,605 | Jason Johnson | Mike Mussina | Jason Johnson | Mike Mussina | | 251 | 267 | -16 |
| 2001-06-06 | @ NYA | 57 | L 4-7 | 27-30 | 3 | 25,137 | Jose Mercedes | Ted Lilly | Mike Stanton | Buddy Groom | Mariano Rivera | 255 | 274 | -19 |
| 2001-06-07 | @ NYA | 58 | L 0-4 | 27-31 | 4 | 30,786 | Sidney Ponson | Roger Clemens | Roger Clemens | Sidney Ponson | | 255 | 278 | -23 |
| 2001-06-08 | vs MON | 59 | W 5-0 | 28-31 | 4 | 39,940 | Josh Towers | Matt Blank | Josh Towers | Matt Blank | | 260 | 278 | -18 |
| 2001-06-09 | vs MON | 60 | L 2-4 | 28-32 | 4 | 39,521 | Willis Roberts | Masato Yoshii | Graeme Lloyd | B.J. Ryan | Ugueth Urbina | 262 | 282 | -20 |
| 2001-06-10 | vs MON | 61 | W 3-2 | 29-32 | 3 | 36,868 | Jason Johnson | Javier Vazquez | Jason Johnson | Javier Vazquez | Buddy Groom | 265 | 284 | -19 |
| 2001-06-12 | vs NYN | 62 | L 3-10 | 29-33 | 4 | 34,812 | Jose Mercedes | Rick Reed | Rick Reed | Jose Mercedes | Rick White | 268 | 294 | -26 |
| 2001-06-13 | vs NYN | 63 | L 6-7 | 29-34 | 4 | 34,881 | Sidney Ponson | Glendon Rusch | John Franco | Buddy Groom | Armando Benitez | 274 | 301 | -27 |
| 2001-06-14 | vs NYN | 64 | W 5-2 | 30-34 | 4 | 37,853 | Josh Towers | Steve Trachsel | Josh Towers | Steve Trachsel | Buddy Groom | 279 | 303 | -24 |
| 2001-06-15 | @ PHI | 65 | L 7-15 | 30-35 | 4 | 18,710 | Willis Roberts | Omar Daal | Vicente Padilla | Willis Roberts | | 286 | 318 | -32 |
| 2001-06-16 | @ PHI | 66 | L 6-14 | 30-36 | 4 | 21,796 | Jason Johnson | Robert Person | Chris Brock | B.J. Ryan | | 292 | 332 | -40 |
| 2001-06-17 | @ PHI | 67 | W 10-7 | 31-36 | 4 | 36,911 | Jose Mercedes | Amaury Telemaco | Jose Mercedes | Amaury Telemaco | | 302 | 339 | -37 |
| 2001-06-18 | vs TOR | 68 | W 3-2 | 32-36 | 3 | 33,605 | Sidney Ponson | Steve Parris | Sidney Ponson | Pedro Borbon | Mike Trombley | 305 | 341 | -36 |
| 2001-06-19 | vs TOR | 69 | W 5-1 | 33-36 | 3 | 31,001 | Josh Towers | Joey Hamilton | Josh Towers | Joey Hamilton | Buddy Groom | 310 | 342 | -32 |
| 2001-06-20 | vs TOR | 70 | L 5-6 | 33-37 | 3 | 30,062 | Willis Roberts | Chris Carpenter | Paul Quantrill | Chuck McElroy | Billy Koch | 315 | 348 | -33 |
| 2001-06-21 | vs CHA | 71 | L 0-6 | 33-38 | 3 | 34,735 | Jason Johnson | Kip Wells | Kip Wells | Jason Johnson | | 315 | 354 | -39 |
| 2001-06-22 | vs CHA | 72 | W 6-4 | 34-38 | 3 | 43,101 | Jose Mercedes | David Wells | Jose Mercedes | David Wells | Buddy Groom | 321 | 358 | -37 |
| 2001-06-23 | vs CHA | 73 | L 3-8 | 34-39 | 4 | 40,796 | Sidney Ponson | Mark Buehrle | Gary Glover | Sidney Ponson | | 324 | 366 | -42 |
| 2001-06-24 | vs CHA | 74 | L 2-8 | 34-40 | 4 | 40,996 | Josh Towers | James Baldwin | James Baldwin | Josh Towers | Sean Lowe | 326 | 374 | -48 |
| 2001-06-25 | @ TOR | 75 | W 8-2 | 35-40 | 4 | 18,243 | Willis Roberts | Joey Hamilton | Willis Roberts | Joey Hamilton | | 334 | 376 | -42 |
| 2001-06-26 | @ TOR | 76 | L 1-3 | 35-41 | 4 | 18,175 | Jason Johnson | Chris Carpenter | Chris Carpenter | Jason Johnson | Billy Koch | 335 | 379 | -44 |
| 2001-06-27 | @ TOR | 77 | W 7-3 | 36-41 | 4 | 17,517 | Jose Mercedes | Esteban Loaiza | Jose Mercedes | Esteban Loaiza | | 342 | 382 | -40 |
| 2001-06-28 | @ TOR | 78 | W 5-0 | 37-41 | 3 | 17,322 | Sidney Ponson | Chris Michalak | Sidney Ponson | Chris Michalak | | 347 | 382 | -35 |
| 2001-06-29 | @ CHA | 79 | W 4-0 | 38-41 | 3 | 27,890 | Josh Towers | Mark Buehrle | Josh Towers | Mark Buehrle | Mike Trombley | 351 | 382 | -31 |
| 2001-06-30 | @ CHA | 80 | L 1-4 | 38-42 | 3 | 33,439 | Willis Roberts | James Baldwin | James Baldwin | Willis Roberts | Keith Foulke | 352 | 386 | -34 |
| 2001-07-01 | @ CHA | 81 | W 11-3 | 39-42 | 3 | 34,588 | Jason Johnson | Rocky Biddle | Jason Johnson | Rocky Biddle | | 363 | 389 | -26 |
| 2001-07-03 | vs NYA | 82 | L 6-10 | 39-43 | 3 | 47,702 | Jose Mercedes | Randy Keisler | Ramiro Mendoza | Jose Mercedes | | 369 | 399 | -30 |
| 2001-07-04 | vs NYA | 83 | L 3-4 | 39-44 | 3 | 47,355 | Sidney Ponson | Roger Clemens | Roger Clemens | Calvin Maduro | Mariano Rivera | 372 | 403 | -31 |
| 2001-07-05 | vs NYA | 84 | L 3-6 | 39-45 | 4 | 44,635 | Josh Towers | Ted Lilly | Ted Lilly | Josh Towers | Mariano Rivera | 375 | 409 | -34 |
| 2001-07-06 | vs PHI | 85 | L 2-3 | 39-46 | 4 | 40,086 | Willis Roberts | Omar Daal | Rheal Cormier | Mike Trombley | Jose Mesa | 377 | 412 | -35 |
| 2001-07-07 | vs PHI | 86 | W 4-3 | 40-46 | 4 | 49,072 | Jason Johnson | Nelson Figueroa | Jason Johnson | Nelson Figueroa | Buddy Groom | 381 | 415 | -34 |
| 2001-07-08 | vs PHI | 87 | L 4-5 | 40-47 | 4 | 47,210 | Jose Mercedes | Robert Person | Randy Wolf | Buddy Groom | Jose Mesa | 385 | 420 | -35 |
| 2001-07-12 | @ ATL | 88 | L 5-6 | 40-48 | 4 | 44,465 | Sidney Ponson | Greg Maddux | Greg Maddux | B.J. Ryan | Steve Karsay | 390 | 426 | -36 |
| 2001-07-13 | @ ATL | 89 | L 1-7 | 40-49 | 4 | 44,461 | Josh Towers | Tom Glavine | Tom Glavine | Josh Towers | | 391 | 433 | -42 |
| 2001-07-14 | @ ATL | 90 | W 4-1 | 41-49 | 4 | 50,069 | Willis Roberts | John Burkett | Willis Roberts | John Burkett | Buddy Groom | 395 | 434 | -39 |
| 2001-07-15 | @ FLO | 91 | L 1-7 | 41-50 | 4 | 25,285 | Jason Johnson | Matt Clement | Matt Clement | Jason Johnson | | 396 | 441 | -45 |
| 2001-07-16 | @ FLO | 92 | L 0-4 | 41-51 | 4 | 16,177 | Jose Mercedes | Jesus Sanchez | Jesus Sanchez | Jose Mercedes | | 396 | 445 | -49 |
| 2001-07-17 | @ FLO | 93 | L 3-8 | 41-52 | 4 | 19,348 | Sidney Ponson | A.J. Burnett | A.J. Burnett | Sidney Ponson | Vic Darensbourg | 399 | 453 | -54 |
| 2001-07-18 | vs TEX | 94 | L 4-6 | 41-53 | 4 | 30,623 | Sean Douglass | Rick Helling | Rick Helling | Sean Douglass | Jeff Zimmerman | 403 | 459 | -56 |
| 2001-07-21 | vs ANA | 95 | L 5-6 | 41-54 | 4 | 47,234 | Josh Towers | Ramon Ortiz | Shigetoshi Hasegawa | Alan Mills | | 408 | 465 | -57 |
| 2001-07-22 | vs ANA | 96 | L 4-9 | 42-55 | 4 | 40,543 | Willis Roberts | Scott Schoeneweis | Ben Weber | Willis Roberts | Lou Pote | 412 | 474 | -62 |
| 2001-07-22 | vs ANA | 97 | W 5-1 | 42-55 | 4 | 38,423 | Jason Johnson | Pat Rapp | Jason Johnson | Toby Borland | Buddy Groom | 417 | 475 | -58 |
| 2001-07-23 | vs ANA | 98 | L 4-9 | 42-56 | 4 | 40,880 | Jose Mercedes | Ismael Valdez | Ismael Valdez | Jose Mercedes | | 421 | 484 | -63 |
| 2001-07-24 | @ TEX | 99 | L 7-8 | 42-57 | 4 | 35,517 | Sidney Ponson | Rick Helling | Mike Venafro | Mike Trombley | Jeff Zimmerman | 428 | 492 | -64 |
| 2001-07-25 | @ TEX | 100 | L 5-6 | 42-59 | 4 | 0 | John Parrish | Justin Duchscherer | Justin Duchscherer | John Parrish | Jeff Zimmerman | 433 | 498 | -65 |
| 2001-07-25 | @ TEX | 101 | L 2-5 | 42-59 | 4 | 37,822 | Calvin Maduro | Doug Davis | Mike Venafro | Jose Mercedes | Jeff Zimmerman | 435 | 503 | -68 |
| 2001-07-26 | @ TEX | 102 | L 7-9 | 42-60 | 4 | 41,668 | Josh Towers | Darren Oliver | Darren Oliver | Josh Towers | Mike Venafro | 442 | 512 | -70 |
| 2001-07-27 | @ ANA | 103 | W 4-3 | 43-60 | 4 | 39,616 | Jason Johnson | Scott Schoeneweis | Mike Trombley | Al Levine | Buddy Groom | 446 | 515 | -69 |
| 2001-07-28 | @ ANA | 104 | L 4-6 | 43-61 | 4 | 39,261 | Willis Roberts | Pat Rapp | Ben Weber | Ryan Kohlmeier | Troy Percival | 450 | 521 | -71 |
| 2001-07-29 | @ ANA | 105 | W 1-0 | 44-61 | 4 | 35,053 | Jose Mercedes | Ismael Valdez | Jose Mercedes | Ismael Valdez | Buddy Groom | 451 | 521 | -70 |
| 2001-07-30 | vs TEX | 106 | L 4-6 | 44-62 | 4 | 38,152 | Sidney Ponson | Doug Davis | Juan Moreno | Mike Trombley | Jeff Zimmerman | 455 | 527 | -72 |
| 2001-07-31 | vs TBA | 107 | L 4-5 | 44-63 | 4 | 41,711 | Josh Towers | Paul Wilson | Paul Wilson | Josh Towers | Esteban Yan | 459 | 532 | -73 |
| 2001-08-01 | vs TBA | 108 | W 6-5 | 45-63 | 4 | 33,618 | Jason Johnson | Ryan Rupe | Alan Mills | Esteban Yan | | 465 | 537 | -72 |
| 2001-08-02 | vs TBA | 109 | L 2-3 | 45-64 | 4 | 40,139 | Calvin Maduro | Tanyon Sturtze | Tanyon Sturtze | Calvin Maduro | Victor Zambrano | 467 | 540 | -73 |
| 2001-08-03 | @ TOR | 110 | L 1-10 | 45-65 | 4 | 20,115 | Jose Mercedes | Kelvim Escobar | Kelvim Escobar | Jose Mercedes | | 468 | 550 | -82 |
| 2001-08-04 | @ TOR | 111 | L 1-2 | 45-66 | 4 | 22,322 | Sidney Ponson | Brandon Lyon | Brandon Lyon | Sidney Ponson | Billy Koch | 469 | 552 | -83 |
| 2001-08-05 | @ TOR | 112 | L 4-5 | 45-67 | 4 | 27,724 | Josh Towers | Esteban Loaiza | Esteban Loaiza | Josh Towers | Billy Koch | 473 | 557 | -84 |
| 2001-08-06 | @ KCA | 113 | W 9-6 | 46-67 | 4 | 22,578 | Jason Johnson | Chris George | Jason Johnson | Chris George | | 482 | 563 | -81 |
| 2001-08-07 | @ KCA | 114 | W 7-3 | 47-67 | 4 | 17,266 | Calvin Maduro | Jeff Suppan | Calvin Maduro | Jeff Suppan | Willis Roberts | 489 | 566 | -77 |
| 2001-08-08 | @ KCA | 115 | W 4-1 | 48-67 | 4 | 17,885 | Jose Mercedes | Chad Durbin | Jose Mercedes | Chad Durbin | Buddy Groom | 493 | 567 | -74 |
| 2001-08-09 | @ KCA | 116 | L 4-6 | 48-68 | 4 | 31,832 | Sidney Ponson | Kris Wilson | Kris Wilson | Sidney Ponson | Roberto Hernandez | 497 | 573 | -76 |
| 2001-08-11 | vs BOS | 117 | W 4-2 | 49-68 | 4 | 48,748 | Josh Towers | David Cone | Josh Towers | David Cone | Willis Roberts | 501 | 575 | -74 |
| 2001-08-12 | vs BOS | 118 | L 10-12 | 49-69 | 4 | 48,037 | Jason Johnson | Rolando Arrojo | Tim Wakefield | Jason Johnson | Derek Lowe | 511 | 587 | -76 |
| 2001-08-14 | vs KCA | 119 | W 5-2 | 50-69 | 4 | 40,539 | Calvin Maduro | Chad Durbin | Calvin Maduro | Chad Durbin | Willis Roberts | 516 | 589 | -73 |
| 2001-08-15 | vs KCA | 120 | W 5-4 | 51-69 | 4 | 38,545 | Jose Mercedes | Kris Wilson | Jose Mercedes | Kris Wilson | Willis Roberts | 521 | 593 | -72 |
| 2001-08-16 | vs KCA | 121 | L 2-9 | 51-70 | 4 | 40,788 | Sidney Ponson | Paul Byrd | Paul Byrd | Sidney Ponson | | 523 | 602 | -79 |
| 2001-08-17 | @ BOS | 122 | W 11-5 | 52-70 | 4 | 33,680 | Josh Towers | Tim Wakefield | Josh Towers | Tim Wakefield | | 534 | 607 | -73 |
| 2001-08-18 | @ BOS | 123 | L 1-5 | 52-71 | 4 | 31,199 | Jason Johnson | Casey Fossum | Rich Garces | Jason Johnson | | 535 | 612 | -77 |
| 2001-08-19 | @ BOS | 124 | W 13-7 | 53-71 | 4 | 33,145 | Calvin Maduro | Hideo Nomo | John Wasdin | Hipolito Pichardo | | 548 | 619 | -71 |
| 2001-08-21 | @ TBA | 125 | L 4-8 | 53-72 | 4 | 13,247 | Jose Mercedes | Paul Wilson | Travis Phelps | Jose Mercedes | | 552 | 627 | -75 |
| 2001-08-22 | @ TBA | 126 | L 10-11 | 53-73 | 4 | 12,113 | Sidney Ponson | Ryan Rupe | Esteban Yan | Willis Roberts | | 562 | 638 | -76 |
| 2001-08-23 | @ TBA | 127 | W 7-4 | 54-73 | 4 | 29,018 | Josh Towers | Nick Bierbrodt | Jorge Julio | Victor Zambrano | Willis Roberts | 569 | 642 | -73 |
| 2001-08-24 | vs TOR | 128 | L 0-5 | 54-74 | 4 | 43,606 | Jason Johnson | Chris Carpenter | Chris Carpenter | Jason Johnson | | 569 | 647 | -78 |
| 2001-08-25 | vs TOR | 129 | L 0-9 | 54-75 | 4 | 42,260 | Calvin Maduro | Kelvim Escobar | Kelvim Escobar | Calvin Maduro | | 569 | 656 | -87 |
| 2001-08-26 | vs TOR | 130 | L 1-5 | 54-76 | 4 | 37,994 | Jose Mercedes | Brandon Lyon | Brandon Lyon | Jose Mercedes | | 570 | 661 | -91 |
| 2001-08-28 | vs OAK | 131 | L 2-6 | 54-77 | 4 | 31,048 | Sidney Ponson | Mark Mulder | Mark Mulder | Sidney Ponson | | 572 | 667 | -95 |
| 2001-08-29 | vs OAK | 132 | L 1-4 | 54-78 | 4 | 31,628 | Josh Towers | Tim Hudson | Tim Hudson | Josh Towers | | 573 | 671 | -98 |
| 2001-08-30 | vs OAK | 133 | L 0-15 | 54-79 | 4 | 44,068 | Jason Johnson | Barry Zito | Barry Zito | Jason Johnson | | 573 | 686 | -113 |
| 2001-08-31 | vs SEA | 134 | W 3-0 | 55-79 | 4 | 37,084 | Calvin Maduro | Aaron Sele | Calvin Maduro | Aaron Sele | | 576 | 686 | -110 |
| 2001-09-01 | vs SEA | 135 | L 4-6 | 55-80 | 4 | 45,668 | Jose Mercedes | Paul Abbott | Paul Abbott | Jose Mercedes | Kazuhiro Sasaki | 580 | 692 | -112 |
| 2001-09-02 | vs SEA | 136 | L 0-1 | 55-81 | 4 | 45,359 | Rick Bauer | Joel Pineiro | Joel Pineiro | Rick Bauer | Kazuhiro Sasaki | 580 | 693 | -113 |
| 2001-09-03 | @ OAK | 137 | L 2-4 | 55-82 | 4 | 28,665 | Josh Towers | Tim Hudson | Tim Hudson | Josh Towers | Jason Isringhausen | 582 | 697 | -115 |
| 2001-09-04 | @ OAK | 138 | L 2-5 | 55-83 | 4 | 16,123 | Jason Johnson | Barry Zito | Barry Zito | Jason Johnson | Jason Isringhausen | 584 | 702 | -118 |
| 2001-09-05 | @ OAK | 139 | L 6-12 | 55-84 | 4 | 30,922 | Calvin Maduro | Cory Lidle | Cory Lidle | Calvin Maduro | | 590 | 714 | -124 |
| 2001-09-07 | @ SEA | 140 | L 1-10 | 55-85 | 4 | 45,797 | Jose Mercedes | Paul Abbott | Paul Abbott | Jose Mercedes | | 591 | 724 | -133 |
| 2001-09-08 | @ SEA | 141 | L 1-6 | 55-86 | 4 | 45,894 | Rick Bauer | Joel Pineiro | Joel Pineiro | Rick Bauer | | 592 | 730 | -138 |
| 2001-09-09 | @ SEA | 142 | L 0-6 | 55-87 | 4 | 45,344 | Josh Towers | Jamie Moyer | Jamie Moyer | Josh Towers | | 592 | 736 | -144 |
| 2001-09-18 | @ TOR | 143 | L 5-8 | 55-88 | 4 | 18,604 | Jason Johnson | Kelvim Escobar | Dan Plesac | Jorge Julio | Billy Koch | 597 | 744 | -147 |
| 2001-09-19 | @ TOR | 144 | L 1-4 | 55-89 | 4 | 31,303 | Calvin Maduro | Roy Halladay | Roy Halladay | Calvin Maduro | Billy Koch | 598 | 748 | -150 |
| 2001-09-20 | @ TOR | 145 | W 12-6 | 56-89 | 4 | 21,895 | Josh Towers | Chris Carpenter | John Parrish | Bob File | | 610 | 754 | -144 |
| 2001-09-21 | vs NYA | 146 | W 7-6 | 57-89 | 4 | 47,099 | Rick Bauer | Mike Mussina | Willis Roberts | Mariano Rivera | | 617 | 760 | -143 |
| 2001-09-22 | vs NYA | 147 | W 11-2 | 58-89 | 4 | 47,068 | Sean Douglass | Sterling Hitchcock | Sean Douglass | Sterling Hitchcock | | 628 | 762 | -134 |
| 2001-09-23 | vs NYA | 148 | L 4-5 | 58-90 | 4 | 46,071 | Jason Johnson | Orlando Hernandez | Mike Stanton | John Parrish | Mariano Rivera | 632 | 767 | -135 |
| 2001-09-24 | @ BOS | 149 | W 5-1 | 59-90 | 4 | 30,114 | Calvin Maduro | David Cone | Calvin Maduro | Tim Wakefield | | 637 | 768 | -131 |
| 2001-09-25 | @ BOS | 150 | W 12-7 | 60-90 | 4 | 29,726 | Jose Mercedes | Frank Castillo | Jose Mercedes | Frank Castillo | | 649 | 775 | -126 |
| 2001-09-26 | @ BOS | 151 | L 6-9 | 60-91 | 4 | 31,603 | Rick Bauer | Casey Fossum | Casey Fossum | Rick Bauer | Ugueth Urbina | 655 | 784 | -129 |
| 2001-09-27 | @ BOS | 152 | W 4-2 | 61-91 | 4 | 32,719 | Sean Douglass | Derek Lowe | Sean Douglass | Tim Wakefield | Willis Roberts | 659 | 786 | -127 |
| 2001-09-28 | @ NYA | 153 | L 0-7 | 61-92 | 4 | 42,066 | Jason Johnson | Mike Mussina | Mike Mussina | Jason Johnson | | 659 | 793 | -134 |
| 2001-09-29 | @ NYA | 154 | W 7-2 | 62-92 | 4 | 55,310 | Calvin Maduro | Orlando Hernandez | Calvin Maduro | Orlando Hernandez | | 666 | 795 | -129 |
| 2001-09-30 | @ NYA | 155 | L 1-1 | 62-93 | 4 | 55,351 | Jose Mercedes | Roger Clemens | | | | 667 | 796 | -129 |
| 2001-10-01 | vs TOR | 156 | L 0-1 | 62-94 | 4 | 37,108 | Rick Bauer | Esteban Loaiza | Esteban Loaiza | Rick Bauer | Billy Koch | 667 | 797 | -130 |
| 2001-10-02 | vs TOR | 157 | W 4-3 | 63-94 | 4 | 29,390 | Sean Douglass | Brandon Lyon | Willis Roberts | Matt DeWitt | | 671 | 800 | -129 |
| 2001-10-03 | vs TOR | 158 | L 6-7 | 63-95 | 4 | 33,705 | Jason Johnson | Pasqual Coco | Scott Eyre | Buddy Groom | Billy Koch | 677 | 807 | -130 |
| 2001-10-04 | vs BOS | 159 | L 4-5 | 63-96 | 4 | 43,302 | Calvin Maduro | Hideo Nomo | Hideo Nomo | John Wasdin | Ugueth Urbina | 681 | 812 | -131 |
| 2001-10-05 | vs BOS | 160 | L 0-5 | 63-98 | 4 | 46,736 | Ryan Kohlmeier | Frank Castillo | Frank Castillo | Ryan Kohlmeier | | 681 | 817 | -136 |
| 2001-10-05 | vs BOS | 161 | L 5-7 | 63-98 | 4 | 47,927 | Jose Mercedes | Sun-Woo Kim | Tim Wakefield | Willis Roberts | Rich Garces | 686 | 824 | -138 |
| 2001-10-06 | vs BOS | 162 | L 1-5 | 63-99 | 4 | 48,807 | Rick Bauer | David Cone | David Cone | Rick Bauer | | 687 | 829 | -142 |