| 2001-04-01 | @ TOR | 1 | L 1-8 | 0-1 | 4 | 19,891 | Rick Helling | Esteban Loaiza | Esteban Loaiza | Rick Helling | | 1 | 8 | -7 |
| 2001-04-03 | vs ANA | 2 | W 3-2 | 1-1 | 3 | 49,512 | Kenny Rogers | Scott Schoeneweis | Kenny Rogers | Scott Schoeneweis | Tim Crabtree | 4 | 10 | -6 |
| 2001-04-04 | vs ANA | 3 | W 7-3 | 2-1 | 2 | 34,321 | Darren Oliver | Pat Rapp | Darren Oliver | Pat Rapp | | 11 | 13 | -2 |
| 2001-04-05 | vs ANA | 4 | L 3-10 | 2-2 | 2 | 34,120 | Ryan Glynn | Ramon Ortiz | Ramon Ortiz | Ryan Glynn | | 14 | 23 | -9 |
| 2001-04-06 | vs SEA | 5 | L 7-9 | 2-3 | 3 | 34,684 | Rick Helling | Jamie Moyer | Arthur Rhodes | Jeff Zimmerman | Kazuhiro Sasaki | 21 | 32 | -11 |
| 2001-04-07 | vs SEA | 6 | L 5-6 | 2-4 | 4 | 41,651 | Doug Davis | Brett Tomko | Ryan Franklin | Doug Davis | Kazuhiro Sasaki | 26 | 38 | -12 |
| 2001-04-08 | vs SEA | 7 | W 5-4 | 3-4 | 3 | 44,306 | Kenny Rogers | Freddy Garcia | Mike Venafro | Jose Paniagua | Tim Crabtree | 31 | 42 | -11 |
| 2001-04-10 | @ ANA | 8 | W 7-5 | 4-4 | 2 | 42,784 | Darren Oliver | Pat Rapp | Darren Oliver | Pat Rapp | Tim Crabtree | 38 | 47 | -9 |
| 2001-04-11 | @ ANA | 9 | L 2-7 | 4-5 | 3 | 16,974 | Ryan Glynn | Ramon Ortiz | Ramon Ortiz | Ryan Glynn | | 40 | 54 | -14 |
| 2001-04-12 | @ ANA | 10 | L 3-13 | 4-6 | 3 | 17,435 | Rick Helling | Matt Wise | Lou Pote | Rick Helling | | 43 | 67 | -24 |
| 2001-04-13 | @ OAK | 11 | W 13-1 | 5-6 | 3 | 19,255 | Doug Davis | Cory Lidle | Doug Davis | Cory Lidle | | 56 | 68 | -12 |
| 2001-04-14 | @ OAK | 12 | W 9-8 | 6-6 | 3 | 26,730 | Kenny Rogers | Barry Zito | Jeff Zimmerman | Jim Mecir | Tim Crabtree | 65 | 76 | -11 |
| 2001-04-15 | @ OAK | 13 | W 10-8 | 7-6 | 2 | 18,853 | Darren Oliver | Gil Heredia | Darren Oliver | Gil Heredia | Mike Venafro | 75 | 84 | -9 |
| 2001-04-16 | @ SEA | 14 | L 7-9 | 7-7 | 2 | 45,657 | Ryan Glynn | Aaron Sele | Ryan Franklin | Ryan Glynn | | 82 | 93 | -11 |
| 2001-04-17 | @ SEA | 15 | L 4-6 | 7-8 | 2 | 34,536 | Rick Helling | Jamie Moyer | Jamie Moyer | Rick Helling | Kazuhiro Sasaki | 86 | 99 | -13 |
| 2001-04-18 | @ SEA | 16 | W 8-6 | 8-8 | 2 | 48,823 | Doug Davis | Brett Tomko | Doug Davis | Brett Tomko | Jeff Zimmerman | 94 | 105 | -11 |
| 2001-04-19 | vs OAK | 17 | L 5-9 | 8-9 | 2 | 33,311 | Kenny Rogers | Barry Zito | Barry Zito | Kenny Rogers | T.J. Mathews | 99 | 114 | -15 |
| 2001-04-20 | vs OAK | 18 | W 9-6 | 9-9 | 2 | 39,041 | Darren Oliver | Gil Heredia | Darren Oliver | Gil Heredia | | 108 | 120 | -12 |
| 2001-04-21 | vs OAK | 19 | L 6-7 | 9-10 | 2 | 45,174 | Ryan Glynn | Mark Mulder | Mark Mulder | Pat Mahomes | Jason Isringhausen | 114 | 127 | -13 |
| 2001-04-22 | vs OAK | 20 | W 11-2 | 10-10 | 2 | 32,527 | Rick Helling | Tim Hudson | Rick Helling | Tim Hudson | | 125 | 129 | -4 |
| 2001-04-24 | @ TOR | 21 | L 5-7 | 10-11 | 2 | 15,381 | Doug Davis | Joey Hamilton | John Frascatore | Pat Mahomes | Billy Koch | 130 | 136 | -6 |
| 2001-04-25 | @ TOR | 22 | L 5-8 | 10-12 | 2 | 15,021 | Kenny Rogers | Chris Carpenter | Paul Quantrill | Kenny Rogers | Billy Koch | 135 | 144 | -9 |
| 2001-04-27 | @ CLE | 23 | W 11-9 | 11-12 | 2 | 40,320 | Darren Oliver | Tim Drew | Pat Mahomes | Tim Drew | Jeff Zimmerman | 146 | 153 | -7 |
| 2001-04-28 | @ CLE | 24 | L 3-7 | 11-13 | 2 | 41,147 | Rick Helling | Dave Burba | Dave Burba | Rick Helling | | 149 | 160 | -11 |
| 2001-04-29 | @ CLE | 25 | L 2-9 | 11-14 | 2 | 40,132 | Doug Davis | Bartolo Colon | Bartolo Colon | Doug Davis | | 151 | 169 | -18 |
| 2001-05-01 | vs DET | 26 | L 3-6 | 11-15 | 3 | 25,638 | Kenny Rogers | Steve Sparks | Danny Patterson | Jeff Zimmerman | Todd Jones | 154 | 175 | -21 |
| 2001-05-02 | vs DET | 27 | L 4-8 | 11-16 | 3 | 33,825 | Darren Oliver | Chris Holt | Chris Holt | Darren Oliver | Matt Anderson | 158 | 183 | -25 |
| 2001-05-03 | vs DET | 28 | L 4-9 | 11-17 | 3 | 34,051 | Rick Helling | Dave Mlicki | Dave Mlicki | Rick Helling | | 162 | 192 | -30 |
| 2001-05-05 | vs CHA | 29 | W 2-0 | 12-17 | 3 | 47,674 | Ryan Glynn | Rocky Biddle | Ryan Glynn | Rocky Biddle | Jeff Zimmerman | 164 | 192 | -28 |
| 2001-05-06 | vs CHA | 30 | L 5-10 | 12-18 | 3 | 34,871 | Kenny Rogers | David Wells | David Wells | Kenny Rogers | Keith Foulke | 169 | 202 | -33 |
| 2001-05-07 | vs CHA | 31 | L 4-7 | 12-19 | 3 | 30,073 | Darren Oliver | Jon Garland | Jon Garland | R.A. Dickey | Keith Foulke | 173 | 209 | -36 |
| 2001-05-08 | @ DET | 32 | L 4-5 | 12-20 | 4 | 21,662 | Rick Helling | Chris Holt | Todd Jones | Tim Crabtree | | 177 | 214 | -37 |
| 2001-05-09 | @ DET | 33 | L 2-3 | 12-21 | 4 | 17,933 | Doug Davis | Dave Mlicki | Dave Mlicki | Doug Davis | Todd Jones | 179 | 217 | -38 |
| 2001-05-10 | @ DET | 34 | L 5-6 | 12-22 | 4 | 25,306 | Ryan Glynn | Jeff Weaver | Danny Patterson | Jeff Zimmerman | Todd Jones | 184 | 223 | -39 |
| 2001-05-11 | @ CHA | 35 | L 5-6 | 12-23 | 4 | 19,399 | Kenny Rogers | David Wells | Bob Howry | Mike Venafro | | 189 | 229 | -40 |
| 2001-05-12 | @ CHA | 36 | W 16-6 | 13-23 | 4 | 31,647 | Aaron Myette | Jon Garland | Pat Mahomes | Jon Garland | | 205 | 235 | -30 |
| 2001-05-13 | @ CHA | 37 | L 3-6 | 13-24 | 4 | 21,019 | Rick Helling | James Baldwin | James Baldwin | Rick Helling | Keith Foulke | 208 | 241 | -33 |
| 2001-05-15 | vs CLE | 38 | L 6-8 | 13-25 | 4 | 39,348 | Doug Davis | CC Sabathia | CC Sabathia | Doug Davis | Bob Wickman | 214 | 249 | -35 |
| 2001-05-16 | vs CLE | 39 | L 3-4 | 13-26 | 4 | 33,695 | Ryan Glynn | Bartolo Colon | Paul Shuey | Tim Crabtree | Bob Wickman | 217 | 253 | -36 |
| 2001-05-17 | vs CLE | 40 | W 12-7 | 14-26 | 4 | 37,191 | Kenny Rogers | Chuck Finley | Kenny Rogers | Chuck Finley | | 229 | 260 | -31 |
| 2001-05-18 | vs TOR | 41 | L 3-9 | 14-27 | 4 | 35,368 | Aaron Myette | Chris Carpenter | Chris Carpenter | Aaron Myette | | 232 | 269 | -37 |
| 2001-05-19 | vs TOR | 42 | L 5-6 | 14-28 | 4 | 48,336 | Rick Helling | Esteban Loaiza | Paul Quantrill | Jeff Brantley | Billy Koch | 237 | 275 | -38 |
| 2001-05-20 | vs TOR | 43 | W 3-2 | 15-28 | 4 | 33,272 | Pat Mahomes | Chris Michalak | Pat Mahomes | Chris Michalak | Jeff Zimmerman | 240 | 277 | -37 |
| 2001-05-22 | @ TBA | 44 | W 5-2 | 16-28 | 4 | 11,179 | Kenny Rogers | Bryan Rekar | Kenny Rogers | Bryan Rekar | | 245 | 279 | -34 |
| 2001-05-23 | @ TBA | 45 | L 6-10 | 16-29 | 4 | 11,164 | Aaron Myette | Brian Rose | Dan Wheeler | Tim Crabtree | | 251 | 289 | -38 |
| 2001-05-24 | @ TBA | 46 | W 9-3 | 17-29 | 4 | 11,181 | Rick Helling | Tanyon Sturtze | Rick Helling | Tanyon Sturtze | | 260 | 292 | -32 |
| 2001-05-25 | @ BAL | 47 | L 6-7 | 17-30 | 4 | 33,117 | Pat Mahomes | Jose Mercedes | Jose Mercedes | Pat Mahomes | Mike Trombley | 266 | 299 | -33 |
| 2001-05-27 | @ BAL | 48 | L 1-3 | 17-31 | 4 | 39,426 | Ryan Glynn | Sidney Ponson | Sidney Ponson | Ryan Glynn | Mike Trombley | 267 | 302 | -35 |
| 2001-05-28 | @ BAL | 49 | W 6-3 | 18-31 | 4 | 37,090 | Kenny Rogers | Josh Towers | J.D. Smart | Chad Paronto | | 273 | 305 | -32 |
| 2001-05-29 | vs KCA | 50 | W 8-2 | 19-31 | 4 | 28,606 | Rick Helling | Mac Suzuki | Rick Helling | Mac Suzuki | | 281 | 307 | -26 |
| 2001-05-30 | vs KCA | 51 | L 2-11 | 19-32 | 4 | 31,290 | Pat Mahomes | Dan Reichert | Dan Reichert | Pat Mahomes | | 283 | 318 | -35 |
| 2001-05-31 | vs KCA | 52 | L 2-8 | 19-33 | 4 | 31,472 | Doug Davis | Blake Stein | Blake Stein | Doug Davis | Kris Wilson | 285 | 326 | -41 |
| 2001-06-01 | vs MIN | 53 | L 7-10 | 19-34 | 4 | 37,617 | Ryan Glynn | Johan Santana | Jack Cressend | Ryan Glynn | Eddie Guardado | 292 | 336 | -44 |
| 2001-06-02 | vs MIN | 54 | W 3-2 | 20-34 | 4 | 46,098 | Kenny Rogers | Brad Radke | Jeff Zimmerman | LaTroy Hawkins | | 295 | 338 | -43 |
| 2001-06-03 | vs MIN | 55 | L 3-6 | 20-35 | 4 | 29,649 | Rick Helling | Eric Milton | Eric Milton | Rick Helling | Eddie Guardado | 298 | 344 | -46 |
| 2001-06-04 | @ SEA | 56 | L 6-11 | 20-36 | 4 | 45,812 | Pat Mahomes | John Halama | Ryan Franklin | Mike Venafro | | 304 | 355 | -51 |
| 2001-06-05 | @ SEA | 57 | L 4-5 | 20-37 | 4 | 44,853 | Doug Davis | Aaron Sele | Jose Paniagua | J.D. Smart | Kazuhiro Sasaki | 308 | 360 | -52 |
| 2001-06-06 | @ SEA | 58 | L 3-7 | 20-38 | 4 | 45,754 | Darren Oliver | Jamie Moyer | Jamie Moyer | Darren Oliver | | 311 | 367 | -56 |
| 2001-06-08 | vs HOU | 59 | L 4-5 | 20-39 | 4 | 47,120 | Kenny Rogers | Roy Oswalt | Octavio Dotel | Tim Crabtree | Michael Jackson | 315 | 372 | -57 |
| 2001-06-09 | vs HOU | 60 | W 16-4 | 21-39 | 4 | 49,603 | Rick Helling | Kent Bottenfield | Rick Helling | Kent Bottenfield | | 331 | 376 | -45 |
| 2001-06-10 | vs HOU | 61 | L 5-6 | 21-40 | 4 | 41,936 | Doug Davis | Wade Miller | Jay Powell | Jeff Zimmerman | Michael Jackson | 336 | 382 | -46 |
| 2001-06-11 | @ LAN | 62 | W 12-7 | 22-40 | 4 | 27,431 | Darren Oliver | Luke Prokopec | Darren Oliver | Luke Prokopec | | 348 | 389 | -41 |
| 2001-06-12 | @ LAN | 63 | L 4-8 | 22-41 | 4 | 26,206 | Mike Judd | Darren Dreifort | Darren Dreifort | Mike Judd | | 352 | 397 | -45 |
| 2001-06-13 | @ LAN | 64 | L 3-5 | 22-42 | 4 | 30,101 | Kenny Rogers | Giovanni Carrara | Matt Herges | J.D. Smart | Jeff Shaw | 355 | 402 | -47 |
| 2001-06-15 | @ HOU | 65 | W 12-9 | 23-42 | 4 | 43,203 | Rick Helling | Wade Miller | Pat Mahomes | Jay Powell | Jeff Zimmerman | 367 | 411 | -44 |
| 2001-06-16 | @ HOU | 66 | L 1-2 | 23-43 | 4 | 43,245 | Doug Davis | Tony McKnight | Nelson Cruz | Tim Crabtree | Michael Jackson | 368 | 413 | -45 |
| 2001-06-17 | @ HOU | 67 | W 6-2 | 24-43 | 4 | 43,277 | Darren Oliver | Scott Elarton | Darren Oliver | Scott Elarton | | 374 | 415 | -41 |
| 2001-06-19 | vs ANA | 68 | W 7-5 | 25-43 | 4 | 31,158 | Rob Bell | Scott Schoeneweis | Juan Moreno | Scott Schoeneweis | Jeff Zimmerman | 381 | 420 | -39 |
| 2001-06-20 | vs ANA | 69 | L 3-4 | 25-44 | 4 | 31,789 | Kenny Rogers | Ramon Ortiz | Ramon Ortiz | Kenny Rogers | Troy Percival | 384 | 424 | -40 |
| 2001-06-21 | vs ANA | 70 | W 4-3 | 26-44 | 4 | 30,337 | Rick Helling | Matt Wise | Rick Helling | Matt Wise | Jeff Zimmerman | 388 | 427 | -39 |
| 2001-06-22 | @ OAK | 71 | W 2-1 | 27-44 | 4 | 18,615 | Doug Davis | Tim Hudson | Doug Davis | Tim Hudson | Jeff Zimmerman | 390 | 428 | -38 |
| 2001-06-23 | @ OAK | 72 | L 4-5 | 27-45 | 4 | 26,324 | Darren Oliver | Barry Zito | Jason Isringhausen | Francisco Cordero | | 394 | 433 | -39 |
| 2001-06-24 | @ OAK | 73 | W 9-5 | 28-45 | 4 | 28,266 | Rob Bell | Gil Heredia | Rob Bell | Gil Heredia | Mike Venafro | 403 | 438 | -35 |
| 2001-06-25 | @ ANA | 74 | L 7-11 | 28-46 | 4 | 17,076 | Kenny Rogers | Ramon Ortiz | Ramon Ortiz | Kenny Rogers | | 410 | 449 | -39 |
| 2001-06-26 | @ ANA | 75 | W 8-1 | 29-46 | 4 | 17,250 | Rick Helling | Matt Wise | Jeff Zimmerman | Mark Lukasiewicz | | 418 | 450 | -32 |
| 2001-06-27 | @ ANA | 76 | L 2-4 | 29-47 | 4 | 17,302 | Doug Davis | Jarrod Washburn | Jarrod Washburn | Doug Davis | Troy Percival | 420 | 454 | -34 |
| 2001-06-28 | @ ANA | 77 | W 6-3 | 30-47 | 4 | 17,951 | Darren Oliver | Pat Rapp | Darren Oliver | Pat Rapp | Jeff Zimmerman | 426 | 457 | -31 |
| 2001-06-29 | vs OAK | 78 | W 9-6 | 31-47 | 4 | 40,025 | Rob Bell | Cory Lidle | Pat Mahomes | Mike Magnante | Jeff Zimmerman | 435 | 463 | -28 |
| 2001-06-30 | vs OAK | 79 | L 4-15 | 31-48 | 4 | 42,553 | Kenny Rogers | Erik Hiljus | Erik Hiljus | Kenny Rogers | | 439 | 478 | -39 |
| 2001-07-01 | vs OAK | 80 | W 3-1 | 32-48 | 4 | 26,547 | Rick Helling | Mark Mulder | Mike Venafro | Mark Mulder | Jeff Zimmerman | 442 | 479 | -37 |
| 2001-07-02 | vs SEA | 81 | L 7-9 | 32-49 | 4 | 28,487 | Doug Davis | Paul Abbott | Jeff Nelson | Mark Petkovsek | Kazuhiro Sasaki | 449 | 488 | -39 |
| 2001-07-03 | vs SEA | 82 | L 4-8 | 32-50 | 4 | 41,849 | Darren Oliver | Aaron Sele | Aaron Sele | Darren Oliver | | 453 | 496 | -43 |
| 2001-07-04 | vs SEA | 83 | W 6-3 | 33-50 | 4 | 49,103 | Rob Bell | Jamie Moyer | Rob Bell | Jamie Moyer | Mike Venafro | 459 | 499 | -40 |
| 2001-07-05 | vs SEA | 84 | W 14-2 | 34-50 | 4 | 29,797 | Kenny Rogers | Denny Stark | Kenny Rogers | Denny Stark | | 473 | 501 | -28 |
| 2001-07-06 | @ SDN | 85 | L 3-8 | 34-51 | 4 | 24,549 | Rick Helling | Kevin Jarvis | Kevin Jarvis | Rick Helling | Trevor Hoffman | 476 | 509 | -33 |
| 2001-07-07 | @ SDN | 86 | W 4-3 | 35-51 | 4 | 44,707 | Doug Davis | Bobby Jones | Doug Davis | Bobby Jones | Jeff Zimmerman | 480 | 512 | -32 |
| 2001-07-08 | @ SDN | 87 | L 2-11 | 35-52 | 4 | 26,866 | Darren Oliver | Woody Williams | Woody Williams | Darren Oliver | | 482 | 523 | -41 |
| 2001-07-12 | vs COL | 88 | W 6-3 | 36-52 | 4 | 29,322 | Kenny Rogers | Pedro Astacio | Kenny Rogers | Pedro Astacio | Jeff Zimmerman | 488 | 526 | -38 |
| 2001-07-13 | vs COL | 89 | W 10-2 | 37-52 | 4 | 37,812 | Rick Helling | Mike Hampton | Rick Helling | Mike Hampton | | 498 | 528 | -30 |
| 2001-07-14 | vs COL | 90 | L 2-11 | 37-53 | 4 | 38,009 | Doug Davis | Shawn Chacon | Shawn Chacon | Doug Davis | | 500 | 539 | -39 |
| 2001-07-15 | vs SFN | 91 | L 6-7 | 37-54 | 4 | 42,082 | Darren Oliver | Livan Hernandez | Livan Hernandez | Darren Oliver | Robb Nen | 506 | 546 | -40 |
| 2001-07-16 | vs SFN | 92 | W 2-0 | 38-54 | 4 | 32,682 | Rob Bell | Ryan Jensen | Rob Bell | Ryan Jensen | Jeff Zimmerman | 508 | 546 | -38 |
| 2001-07-17 | vs SFN | 93 | L 2-10 | 38-55 | 4 | 31,162 | Kenny Rogers | Kirk Rueter | Kirk Rueter | Kenny Rogers | | 510 | 556 | -46 |
| 2001-07-18 | @ BAL | 94 | W 6-4 | 39-55 | 4 | 30,623 | Rick Helling | Sean Douglass | Rick Helling | Sean Douglass | Jeff Zimmerman | 516 | 560 | -44 |
| 2001-07-20 | @ TBA | 95 | W 4-1 | 40-55 | 4 | 13,611 | Doug Davis | Albie Lopez | Doug Davis | Albie Lopez | Jeff Zimmerman | 520 | 561 | -41 |
| 2001-07-21 | @ TBA | 96 | L 1-2 | 40-56 | 4 | 37,070 | Darren Oliver | Ryan Rupe | Victor Zambrano | Darren Oliver | Esteban Yan | 521 | 563 | -42 |
| 2001-07-22 | @ TBA | 97 | L 4-7 | 40-57 | 4 | 14,732 | Rob Bell | Tanyon Sturtze | Tanyon Sturtze | Juan Moreno | Esteban Yan | 525 | 570 | -45 |
| 2001-07-24 | vs BAL | 98 | W 8-7 | 41-57 | 4 | 35,517 | Rick Helling | Sidney Ponson | Mike Venafro | Mike Trombley | Jeff Zimmerman | 533 | 577 | -44 |
| 2001-07-25 | vs BAL | 99 | W 6-5 | 43-57 | 4 | 0 | Justin Duchscherer | John Parrish | Justin Duchscherer | John Parrish | Jeff Zimmerman | 539 | 582 | -43 |
| 2001-07-25 | vs BAL | 100 | W 5-2 | 43-57 | 4 | 37,822 | Doug Davis | Calvin Maduro | Mike Venafro | Jose Mercedes | Jeff Zimmerman | 544 | 584 | -40 |
| 2001-07-26 | vs BAL | 101 | W 9-7 | 44-57 | 4 | 41,668 | Darren Oliver | Josh Towers | Darren Oliver | Josh Towers | Mike Venafro | 553 | 591 | -38 |
| 2001-07-27 | vs TBA | 102 | W 13-7 | 45-57 | 4 | 38,213 | Rob Bell | Tanyon Sturtze | Rob Bell | Tanyon Sturtze | | 566 | 598 | -32 |
| 2001-07-28 | vs TBA | 103 | L 3-7 | 45-58 | 4 | 39,023 | Aaron Myette | Nick Bierbrodt | Esteban Yan | Kevin Foster | | 569 | 605 | -36 |
| 2001-07-29 | vs TBA | 104 | W 2-0 | 46-58 | 4 | 28,084 | Rick Helling | Joe Kennedy | Rick Helling | Joe Kennedy | | 571 | 605 | -34 |
| 2001-07-30 | @ BAL | 105 | W 6-4 | 47-58 | 4 | 38,152 | Doug Davis | Sidney Ponson | Juan Moreno | Mike Trombley | Jeff Zimmerman | 577 | 609 | -32 |
| 2001-07-31 | @ NYA | 106 | W 6-2 | 48-58 | 4 | 45,978 | Darren Oliver | Ted Lilly | Darren Oliver | Ted Lilly | Jeff Zimmerman | 583 | 611 | -28 |
| 2001-08-01 | @ NYA | 107 | L 7-9 | 48-59 | 4 | 41,714 | Rob Bell | Sterling Hitchcock | Sterling Hitchcock | Rob Bell | Mariano Rivera | 590 | 620 | -30 |
| 2001-08-02 | @ NYA | 108 | W 12-2 | 49-59 | 4 | 52,169 | Aaron Myette | Mike Mussina | Aaron Myette | Mike Mussina | | 602 | 622 | -20 |
| 2001-08-04 | @ BOS | 109 | L 4-10 | 49-61 | 4 | 32,249 | Rick Helling | David Cone | David Cone | Rick Helling | | 606 | 632 | -26 |
| 2001-08-04 | @ BOS | 110 | L 2-6 | 49-61 | 4 | 32,338 | Doug Davis | Tim Wakefield | Tim Wakefield | Doug Davis | | 608 | 638 | -30 |
| 2001-08-05 | @ BOS | 111 | L 3-6 | 49-62 | 4 | 32,923 | Darren Oliver | Rolando Arrojo | Rolando Arrojo | Darren Oliver | Derek Lowe | 611 | 644 | -33 |
| 2001-08-06 | @ BOS | 112 | L 7-10 | 49-63 | 4 | 33,977 | Rob Bell | Hideo Nomo | Casey Fossum | Juan Moreno | Derek Lowe | 618 | 654 | -36 |
| 2001-08-07 | vs DET | 113 | L 3-7 | 49-64 | 4 | 26,621 | Aaron Myette | Adam Pettyjohn | Matt Perisho | Mike Venafro | | 621 | 661 | -40 |
| 2001-08-08 | vs DET | 114 | L 6-19 | 49-65 | 4 | 30,016 | Joaquin Benoit | Nate Cornejo | Danny Patterson | Mike Venafro | | 627 | 680 | -53 |
| 2001-08-09 | vs DET | 115 | W 7-3 | 50-65 | 4 | 27,652 | Rick Helling | Steve Sparks | Rick Helling | Steve Sparks | | 634 | 683 | -49 |
| 2001-08-10 | vs CLE | 116 | W 7-2 | 51-65 | 4 | 47,242 | Doug Davis | Steve Woodard | Doug Davis | Steve Woodard | | 641 | 685 | -44 |
| 2001-08-11 | vs CLE | 117 | W 6-5 | 52-65 | 4 | 43,145 | Darren Oliver | Charles Nagy | Mark Petkovsek | John Rocker | Jeff Zimmerman | 647 | 690 | -43 |
| 2001-08-12 | vs CLE | 118 | L 2-13 | 52-66 | 4 | 28,765 | Rob Bell | CC Sabathia | CC Sabathia | Rob Bell | | 649 | 703 | -54 |
| 2001-08-14 | @ CHA | 119 | L 4-7 | 52-67 | 4 | 22,336 | Aaron Myette | Mark Buehrle | Mark Buehrle | Aaron Myette | Keith Foulke | 653 | 710 | -57 |
| 2001-08-15 | @ CHA | 120 | L 5-6 | 52-68 | 4 | 18,062 | Rick Helling | Sean Lowe | Kip Wells | Pat Mahomes | Keith Foulke | 658 | 716 | -58 |
| 2001-08-16 | @ CHA | 121 | L 5-7 | 52-69 | 4 | 20,252 | Doug Davis | Jon Garland | Kip Wells | Mark Petkovsek | Keith Foulke | 663 | 723 | -60 |
| 2001-08-17 | @ TOR | 122 | L 3-11 | 52-70 | 4 | 22,384 | Darren Oliver | Esteban Loaiza | Esteban Loaiza | Darren Oliver | | 666 | 734 | -68 |
| 2001-08-18 | @ TOR | 123 | W 12-5 | 53-70 | 4 | 26,092 | Rob Bell | Roy Halladay | Juan Moreno | Billy Koch | | 678 | 739 | -61 |
| 2001-08-19 | @ TOR | 124 | W 8-4 | 54-70 | 4 | 30,336 | Aaron Myette | Chris Carpenter | Aaron Myette | Chris Carpenter | | 686 | 743 | -57 |
| 2001-08-20 | vs NYA | 125 | L 5-9 | 54-71 | 4 | 35,125 | Rick Helling | Roger Clemens | Mike Stanton | Juan Moreno | | 691 | 752 | -61 |
| 2001-08-21 | vs NYA | 126 | W 13-3 | 55-71 | 4 | 34,940 | Doug Davis | Orlando Hernandez | Doug Davis | Orlando Hernandez | | 704 | 755 | -51 |
| 2001-08-22 | vs NYA | 127 | W 8-1 | 56-71 | 4 | 33,442 | Darren Oliver | Mike Mussina | Darren Oliver | Mike Mussina | | 712 | 756 | -44 |
| 2001-08-23 | vs NYA | 128 | L 2-5 | 56-72 | 4 | 36,158 | Rob Bell | Sterling Hitchcock | Sterling Hitchcock | Rob Bell | Mariano Rivera | 714 | 761 | -47 |
| 2001-08-24 | vs BOS | 129 | L 4-7 | 56-73 | 4 | 45,378 | Aaron Myette | Hideo Nomo | Rod Beck | Chris Michalak | Ugueth Urbina | 718 | 768 | -50 |
| 2001-08-25 | vs BOS | 130 | W 8-7 | 57-73 | 4 | 43,775 | Rick Helling | Frank Castillo | Chris Michalak | Derek Lowe | | 726 | 775 | -49 |
| 2001-08-26 | vs BOS | 131 | W 5-4 | 58-73 | 4 | 26,208 | Doug Davis | Pedro Martinez | Doug Davis | Tim Wakefield | Jeff Zimmerman | 731 | 779 | -48 |
| 2001-08-28 | @ MIN | 132 | W 10-1 | 59-73 | 4 | 12,213 | Darren Oliver | Rick Reed | Darren Oliver | Rick Reed | | 741 | 780 | -39 |
| 2001-08-29 | @ MIN | 133 | L 8-10 | 59-74 | 4 | 13,682 | Rob Bell | Eric Milton | Eric Milton | Rob Bell | LaTroy Hawkins | 749 | 790 | -41 |
| 2001-08-30 | @ MIN | 134 | W 5-1 | 60-74 | 4 | 11,820 | Aaron Myette | Joe Mays | Aaron Myette | Joe Mays | | 754 | 791 | -37 |
| 2001-08-31 | @ KCA | 135 | W 7-2 | 61-74 | 4 | 15,071 | Rick Helling | Paul Byrd | Rick Helling | Paul Byrd | | 761 | 793 | -32 |
| 2001-09-01 | @ KCA | 136 | L 7-8 | 61-75 | 4 | 24,160 | Doug Davis | Kris Wilson | Roberto Hernandez | Pat Mahomes | | 768 | 801 | -33 |
| 2001-09-02 | @ KCA | 137 | W 12-6 | 62-75 | 4 | 18,389 | Darren Oliver | Chris George | Chris Michalak | Chris George | | 780 | 807 | -27 |
| 2001-09-04 | vs MIN | 138 | W 6-5 | 63-75 | 4 | 22,045 | Rob Bell | Eric Milton | Mike Venafro | LaTroy Hawkins | | 786 | 812 | -26 |
| 2001-09-05 | vs MIN | 139 | L 2-12 | 63-76 | 4 | 29,853 | Aaron Myette | Joe Mays | Joe Mays | Aaron Myette | | 788 | 824 | -36 |
| 2001-09-06 | vs MIN | 140 | W 4-3 | 64-76 | 4 | 26,192 | Rick Helling | Brad Radke | Rick Helling | Brad Radke | Jeff Zimmerman | 792 | 827 | -35 |
| 2001-09-07 | vs KCA | 141 | W 8-2 | 65-76 | 4 | 29,954 | Doug Davis | Kris Wilson | Doug Davis | Kris Wilson | | 800 | 829 | -29 |
| 2001-09-08 | vs KCA | 142 | L 3-8 | 65-77 | 4 | 37,501 | Darren Oliver | Chris George | Chris George | Darren Oliver | | 803 | 837 | -34 |
| 2001-09-09 | vs KCA | 143 | W 4-3 | 66-77 | 4 | 24,057 | Rob Bell | Jeff Suppan | Jeff Zimmerman | Roberto Hernandez | | 807 | 840 | -33 |
| 2001-09-10 | @ OAK | 144 | L 1-7 | 66-78 | 4 | 12,115 | Aaron Myette | Barry Zito | Barry Zito | Aaron Myette | | 808 | 847 | -39 |
| 2001-09-18 | vs OAK | 145 | L 5-6 | 66-79 | 4 | 21,517 | Rick Helling | Mark Mulder | Mark Mulder | Mike Venafro | Jason Isringhausen | 813 | 853 | -40 |
| 2001-09-19 | vs OAK | 146 | W 10-4 | 67-79 | 4 | 25,013 | Doug Davis | Tim Hudson | Doug Davis | Tim Hudson | Chris Michalak | 823 | 857 | -34 |
| 2001-09-20 | vs OAK | 147 | L 2-7 | 67-80 | 4 | 22,219 | Darren Oliver | Barry Zito | Barry Zito | Darren Oliver | | 825 | 864 | -39 |
| 2001-09-21 | vs ANA | 148 | W 9-8 | 68-80 | 4 | 37,291 | Rob Bell | Ismael Valdez | Rob Bell | Ismael Valdez | Jeff Zimmerman | 834 | 872 | -38 |
| 2001-09-22 | vs ANA | 149 | W 5-4 | 69-80 | 4 | 38,781 | Aaron Myette | Matt Wise | Pat Mahomes | Mike Holtz | | 839 | 876 | -37 |
| 2001-09-23 | vs ANA | 150 | W 5-2 | 70-80 | 4 | 34,542 | Rick Helling | Ramon Ortiz | Rick Helling | Ramon Ortiz | Jeff Zimmerman | 844 | 878 | -34 |
| 2001-09-24 | vs SEA | 151 | L 3-9 | 70-81 | 4 | 22,765 | Doug Davis | Jamie Moyer | Jamie Moyer | Doug Davis | | 847 | 887 | -40 |
| 2001-09-25 | vs SEA | 152 | L 2-13 | 70-82 | 4 | 27,781 | Justin Duchscherer | Aaron Sele | Aaron Sele | Justin Duchscherer | | 849 | 900 | -51 |
| 2001-09-26 | vs SEA | 153 | L 5-7 | 70-83 | 4 | 24,712 | Rob Bell | Paul Abbott | Paul Abbott | Rob Bell | Kazuhiro Sasaki | 854 | 907 | -53 |
| 2001-09-28 | @ ANA | 154 | W 11-2 | 71-83 | 4 | 26,128 | Aaron Myette | Ismael Valdez | Aaron Myette | Ismael Valdez | | 865 | 909 | -44 |
| 2001-09-29 | @ ANA | 155 | L 2-13 | 71-84 | 4 | 26,439 | Rick Helling | Ramon Ortiz | Ramon Ortiz | Rick Helling | | 867 | 922 | -55 |
| 2001-09-30 | @ ANA | 156 | W 8-6 | 72-84 | 4 | 17,507 | Doug Davis | Scott Schoeneweis | Doug Davis | Shigetoshi Hasegawa | Jeff Zimmerman | 875 | 928 | -53 |
| 2001-10-02 | @ OAK | 157 | L 4-9 | 72-85 | 4 | 18,336 | Darren Oliver | Barry Zito | Barry Zito | Darren Oliver | | 879 | 937 | -58 |
| 2001-10-03 | @ OAK | 158 | L 4-5 | 72-86 | 4 | 23,740 | Rob Bell | Cory Lidle | Cory Lidle | Chris Michalak | Jason Isringhausen | 883 | 942 | -59 |
| 2001-10-04 | @ SEA | 159 | L 1-16 | 72-87 | 4 | 45,302 | Aaron Myette | Brett Tomko | Brett Tomko | Aaron Myette | | 884 | 958 | -74 |
| 2001-10-05 | @ SEA | 160 | L 2-6 | 72-88 | 4 | 45,333 | Rick Helling | Jamie Moyer | Jamie Moyer | Rick Helling | | 886 | 964 | -78 |
| 2001-10-06 | @ SEA | 161 | L 0-1 | 72-89 | 4 | 45,607 | Doug Davis | Denny Stark | Joel Pineiro | Doug Davis | Kazuhiro Sasaki | 886 | 965 | -79 |
| 2001-10-07 | @ SEA | 162 | W 4-3 | 73-89 | 4 | 45,578 | Darren Oliver | Aaron Sele | Pat Mahomes | Jeff Nelson | Jeff Zimmerman | 890 | 968 | -78 |