| 2001-04-03 | vs TOR | 1 | W 8-1 | 1-0 | 3 | 41,546 | Albie Lopez | Steve Parris | Albie Lopez | Steve Parris | | 8 | 1 | 7 |
| 2001-04-04 | vs TOR | 2 | L 8-11 | 1-1 | 5 | 15,172 | Paul Wilson | Joey Hamilton | Paul Quantrill | Ken Hill | Billy Koch | 16 | 12 | 4 |
| 2001-04-05 | vs TOR | 3 | L 0-11 | 1-2 | 5 | 14,023 | Bryan Rekar | Chris Carpenter | Chris Carpenter | Bryan Rekar | | 16 | 23 | -7 |
| 2001-04-06 | @ BOS | 4 | L 4-11 | 1-3 | 5 | 33,525 | Ryan Rupe | Tomo Ohka | Tim Wakefield | Ryan Rupe | | 20 | 34 | -14 |
| 2001-04-07 | @ BOS | 5 | L 2-6 | 1-4 | 5 | 31,660 | Travis Harper | Paxton Crawford | Paxton Crawford | Travis Harper | | 22 | 40 | -18 |
| 2001-04-08 | @ BOS | 6 | L 0-3 | 1-5 | 5 | 31,383 | Albie Lopez | Pedro Martinez | Pedro Martinez | Albie Lopez | Derek Lowe | 22 | 43 | -21 |
| 2001-04-09 | @ TOR | 7 | L 1-8 | 1-6 | 5 | 48,115 | Paul Wilson | Joey Hamilton | Joey Hamilton | Paul Wilson | | 23 | 51 | -28 |
| 2001-04-10 | @ TOR | 8 | L 2-3 | 1-7 | 5 | 18,071 | Bryan Rekar | Chris Carpenter | Paul Quantrill | Tanyon Sturtze | | 25 | 54 | -29 |
| 2001-04-11 | @ TOR | 9 | W 4-3 | 2-7 | 5 | 24,017 | Ryan Rupe | Esteban Loaiza | Esteban Yan | Billy Koch | | 29 | 57 | -28 |
| 2001-04-13 | @ BAL | 10 | W 2-0 | 3-7 | 5 | 34,656 | Albie Lopez | Pat Hentgen | Albie Lopez | Pat Hentgen | | 31 | 57 | -26 |
| 2001-04-14 | @ BAL | 11 | L 5-6 | 3-8 | 5 | 43,621 | Paul Wilson | Chuck McElroy | John Bale | Rusty Meacham | Ryan Kohlmeier | 36 | 63 | -27 |
| 2001-04-15 | @ BAL | 12 | W 7-4 | 4-8 | 5 | 30,441 | Bryan Rekar | Sidney Ponson | Doug Creek | Sidney Ponson | Esteban Yan | 43 | 67 | -24 |
| 2001-04-16 | @ BAL | 13 | L 2-6 | 4-9 | 5 | 24,558 | Ryan Rupe | Jason Johnson | Jason Johnson | Ryan Rupe | | 45 | 73 | -28 |
| 2001-04-17 | vs BOS | 14 | L 0-10 | 4-10 | 5 | 19,433 | Travis Harper | Tomo Ohka | Tomo Ohka | Travis Harper | | 45 | 83 | -38 |
| 2001-04-18 | vs BOS | 15 | L 1-9 | 4-11 | 5 | 16,622 | Albie Lopez | Paxton Crawford | Rolando Arrojo | Tanyon Sturtze | | 46 | 92 | -46 |
| 2001-04-19 | vs BOS | 16 | L 3-8 | 4-12 | 5 | 22,026 | Paul Wilson | Pedro Martinez | Pedro Martinez | Paul Wilson | Derek Lowe | 49 | 100 | -51 |
| 2001-04-20 | vs BAL | 17 | L 3-6 | 4-13 | 5 | 13,013 | Bryan Rekar | Willis Roberts | Willis Roberts | Bryan Rekar | Ryan Kohlmeier | 52 | 106 | -54 |
| 2001-04-21 | vs BAL | 18 | W 6-5 | 5-13 | 5 | 14,026 | Ryan Rupe | Jason Johnson | Ryan Rupe | Jason Johnson | Esteban Yan | 58 | 111 | -53 |
| 2001-04-22 | vs BAL | 19 | L 8-10 | 5-14 | 5 | 18,934 | Mike Judd | Jose Mercedes | Chad Paronto | Esteban Yan | | 66 | 121 | -55 |
| 2001-04-24 | vs KCA | 20 | W 4-2 | 6-14 | 5 | 11,056 | Albie Lopez | Brian Meadows | Albie Lopez | Brian Meadows | Esteban Yan | 70 | 123 | -53 |
| 2001-04-25 | vs KCA | 21 | W 5-3 | 7-14 | 5 | 11,119 | Paul Wilson | Jeff Suppan | Paul Wilson | Jeff Suppan | Esteban Yan | 75 | 126 | -51 |
| 2001-04-26 | vs KCA | 22 | L 0-6 | 7-15 | 5 | 11,083 | Bryan Rekar | Mac Suzuki | Mac Suzuki | Bryan Rekar | | 75 | 132 | -57 |
| 2001-04-27 | @ DET | 23 | L 2-4 | 7-16 | 5 | 16,458 | Ryan Rupe | Dave Mlicki | Dave Mlicki | Ryan Rupe | Todd Jones | 77 | 136 | -59 |
| 2001-04-28 | @ DET | 24 | W 7-3 | 8-16 | 5 | 18,666 | Mike Judd | Matt Perisho | Mike Judd | Matt Perisho | | 84 | 139 | -55 |
| 2001-04-29 | @ DET | 25 | L 1-6 | 8-17 | 5 | 16,769 | Albie Lopez | Jeff Weaver | Jeff Weaver | Albie Lopez | | 85 | 145 | -60 |
| 2001-04-30 | @ BAL | 26 | L 3-5 | 8-18 | 5 | 28,510 | Paul Wilson | Willis Roberts | Willis Roberts | Paul Wilson | Ryan Kohlmeier | 88 | 150 | -62 |
| 2001-05-01 | @ BAL | 27 | L 1-3 | 8-19 | 5 | 27,208 | Bryan Rekar | Jason Johnson | Jason Johnson | Bryan Rekar | Ryan Kohlmeier | 89 | 153 | -64 |
| 2001-05-02 | @ BAL | 28 | W 7-1 | 9-19 | 5 | 26,615 | Ryan Rupe | Jose Mercedes | Ryan Rupe | Jose Mercedes | Tanyon Sturtze | 96 | 154 | -58 |
| 2001-05-04 | vs CLE | 29 | L 6-8 | 9-20 | 5 | 16,478 | Albie Lopez | Bartolo Colon | Bartolo Colon | Albie Lopez | Paul Shuey | 102 | 162 | -60 |
| 2001-05-05 | vs CLE | 30 | L 4-9 | 9-21 | 5 | 16,180 | Paul Wilson | Tim Drew | Justin Speier | Paul Wilson | Steve Karsay | 106 | 171 | -65 |
| 2001-05-06 | vs CLE | 31 | L 3-10 | 9-22 | 5 | 19,511 | Bryan Rekar | Chuck Finley | Chuck Finley | Doug Creek | | 109 | 181 | -72 |
| 2001-05-08 | vs BAL | 32 | W 4-3 | 10-22 | 5 | 11,078 | Tanyon Sturtze | Jose Mercedes | Rusty Meacham | Jose Mercedes | Esteban Yan | 113 | 184 | -71 |
| 2001-05-09 | vs BAL | 33 | L 6-8 | 10-23 | 5 | 11,108 | Albie Lopez | Sidney Ponson | Josh Towers | Ryan Rupe | Mike Trombley | 119 | 192 | -73 |
| 2001-05-10 | vs BAL | 34 | L 5-9 | 10-24 | 5 | 11,089 | Paul Wilson | Pat Hentgen | B.J. Ryan | Rusty Meacham | | 124 | 201 | -77 |
| 2001-05-11 | @ CLE | 35 | L 6-10 | 10-25 | 5 | 42,009 | Bryan Rekar | Tim Drew | Rich Rodriguez | Bryan Rekar | | 130 | 211 | -81 |
| 2001-05-12 | @ CLE | 36 | L 0-8 | 10-26 | 5 | 40,399 | Brian Rose | Chuck Finley | Chuck Finley | Brian Rose | | 130 | 219 | -89 |
| 2001-05-13 | @ CLE | 37 | W 7-0 | 11-26 | 5 | 41,399 | Tanyon Sturtze | Dave Burba | Tanyon Sturtze | Dave Burba | | 137 | 219 | -82 |
| 2001-05-15 | @ KCA | 38 | L 2-6 | 11-27 | 5 | 12,858 | Paul Wilson | Brian Meadows | Jose Santiago | Paul Wilson | | 139 | 225 | -86 |
| 2001-05-16 | @ KCA | 39 | L 5-9 | 11-28 | 5 | 12,378 | Bryan Rekar | Jeff Suppan | Roberto Hernandez | Esteban Yan | | 144 | 234 | -90 |
| 2001-05-17 | @ KCA | 40 | L 2-4 | 11-29 | 5 | 14,272 | Brian Rose | Chad Durbin | Chad Durbin | Brian Rose | Roberto Hernandez | 146 | 238 | -92 |
| 2001-05-18 | vs DET | 41 | L 2-18 | 11-30 | 5 | 12,131 | Tanyon Sturtze | Victor Santos | Victor Santos | Tanyon Sturtze | | 148 | 256 | -108 |
| 2001-05-19 | vs DET | 42 | L 5-10 | 11-31 | 5 | 13,304 | Albie Lopez | Chris Holt | Chris Holt | Albie Lopez | Danny Patterson | 153 | 266 | -113 |
| 2001-05-20 | vs DET | 43 | W 10-2 | 12-31 | 5 | 13,512 | Paul Wilson | Dave Mlicki | Paul Wilson | Dave Mlicki | | 163 | 268 | -105 |
| 2001-05-22 | vs TEX | 44 | L 2-5 | 12-32 | 5 | 11,179 | Bryan Rekar | Kenny Rogers | Kenny Rogers | Bryan Rekar | | 165 | 273 | -108 |
| 2001-05-23 | vs TEX | 45 | W 10-6 | 13-32 | 5 | 11,164 | Brian Rose | Aaron Myette | Dan Wheeler | Tim Crabtree | | 175 | 279 | -104 |
| 2001-05-24 | vs TEX | 46 | L 3-9 | 13-33 | 5 | 11,181 | Tanyon Sturtze | Rick Helling | Rick Helling | Tanyon Sturtze | | 178 | 288 | -110 |
| 2001-05-25 | vs ANA | 47 | L 4-6 | 13-34 | 5 | 10,946 | Albie Lopez | Pat Rapp | Ben Weber | Albie Lopez | Troy Percival | 182 | 294 | -112 |
| 2001-05-26 | vs ANA | 48 | L 4-10 | 13-35 | 5 | 13,496 | Paul Wilson | Jarrod Washburn | Jarrod Washburn | Paul Wilson | | 186 | 304 | -118 |
| 2001-05-27 | vs ANA | 49 | W 4-3 | 14-35 | 5 | 11,808 | Bryan Rekar | Ismael Valdez | Esteban Yan | Al Levine | | 190 | 307 | -117 |
| 2001-05-28 | vs ANA | 50 | L 1-3 | 14-36 | 5 | 11,127 | Ryan Rupe | Scott Schoeneweis | Scott Schoeneweis | Rusty Meacham | Troy Percival | 191 | 310 | -119 |
| 2001-05-29 | @ OAK | 51 | W 5-1 | 15-36 | 5 | 11,334 | Tanyon Sturtze | Cory Lidle | Tanyon Sturtze | Cory Lidle | Travis Phelps | 196 | 311 | -115 |
| 2001-05-30 | @ OAK | 52 | L 2-15 | 15-37 | 5 | 17,901 | Albie Lopez | Mark Mulder | Mark Mulder | Albie Lopez | | 198 | 326 | -128 |
| 2001-05-31 | @ OAK | 53 | L 1-10 | 15-38 | 5 | 16,308 | Paul Wilson | Tim Hudson | Tim Hudson | Paul Wilson | | 199 | 336 | -137 |
| 2001-06-01 | @ SEA | 54 | L 4-8 | 15-39 | 5 | 41,094 | Bryan Rekar | Jamie Moyer | Jamie Moyer | Bryan Rekar | Jeff Nelson | 203 | 344 | -141 |
| 2001-06-02 | @ SEA | 55 | L 4-7 | 15-40 | 5 | 45,473 | Ryan Rupe | Paul Abbott | Paul Abbott | Ryan Rupe | Kazuhiro Sasaki | 207 | 351 | -144 |
| 2001-06-03 | @ SEA | 56 | L 4-8 | 15-41 | 5 | 45,390 | Tanyon Sturtze | Freddy Garcia | Freddy Garcia | Tanyon Sturtze | Kazuhiro Sasaki | 211 | 359 | -148 |
| 2001-06-05 | @ TOR | 57 | L 1-13 | 15-42 | 5 | 15,078 | Albie Lopez | Esteban Loaiza | Esteban Loaiza | Albie Lopez | | 212 | 372 | -160 |
| 2001-06-06 | @ TOR | 58 | W 6-2 | 16-42 | 5 | 16,298 | Joe Kennedy | Chris Michalak | Joe Kennedy | Chris Michalak | | 218 | 374 | -156 |
| 2001-06-07 | @ TOR | 59 | L 7-8 | 16-43 | 5 | 26,835 | Bryan Rekar | Steve Parris | Pedro Borbon | Travis Phelps | | 225 | 382 | -157 |
| 2001-06-08 | vs NYN | 60 | W 7-5 | 17-43 | 5 | 15,547 | Ryan Rupe | Steve Trachsel | Ryan Rupe | Steve Trachsel | Esteban Yan | 232 | 387 | -155 |
| 2001-06-09 | vs NYN | 61 | W 5-2 | 18-43 | 5 | 19,235 | Tanyon Sturtze | Al Leiter | Tanyon Sturtze | Al Leiter | Travis Phelps | 237 | 389 | -152 |
| 2001-06-10 | vs NYN | 62 | L 0-10 | 18-44 | 5 | 19,994 | Albie Lopez | Kevin Appier | Kevin Appier | Albie Lopez | | 237 | 399 | -162 |
| 2001-06-12 | vs PHI | 63 | W 9-5 | 19-44 | 5 | 12,602 | Joe Kennedy | Amaury Telemaco | Joe Kennedy | Amaury Telemaco | | 246 | 404 | -158 |
| 2001-06-13 | vs PHI | 64 | W 5-3 | 20-44 | 5 | 10,539 | Bryan Rekar | Bruce Chen | Bryan Rekar | Ricky Bottalico | Esteban Yan | 251 | 407 | -156 |
| 2001-06-14 | vs PHI | 65 | W 6-3 | 21-44 | 5 | 11,606 | Ryan Rupe | Randy Wolf | Ryan Rupe | Randy Wolf | Esteban Yan | 257 | 410 | -153 |
| 2001-06-15 | @ FLO | 66 | L 4-7 | 21-45 | 5 | 14,387 | Tanyon Sturtze | A.J. Burnett | A.J. Burnett | Tanyon Sturtze | | 261 | 417 | -156 |
| 2001-06-16 | @ FLO | 67 | L 0-11 | 21-46 | 5 | 16,877 | Albie Lopez | Brad Penny | Brad Penny | Albie Lopez | | 261 | 428 | -167 |
| 2001-06-17 | @ FLO | 68 | L 4-6 | 21-47 | 5 | 13,281 | Joe Kennedy | Ryan Dempster | Ryan Dempster | Joe Kennedy | Antonio Alfonseca | 265 | 434 | -169 |
| 2001-06-19 | vs BOS | 69 | L 4-5 | 21-48 | 5 | 12,550 | Bryan Rekar | Tim Wakefield | Tim Wakefield | Bryan Rekar | Derek Lowe | 269 | 439 | -170 |
| 2001-06-20 | vs BOS | 70 | L 2-8 | 21-49 | 5 | 12,520 | Ryan Rupe | David Cone | Rich Garces | Ryan Rupe | | 271 | 447 | -176 |
| 2001-06-21 | vs BOS | 71 | L 4-7 | 21-50 | 5 | 15,603 | Tanyon Sturtze | Pedro Martinez | Rod Beck | Esteban Yan | Derek Lowe | 275 | 454 | -179 |
| 2001-06-22 | vs NYA | 72 | L 3-6 | 21-51 | 5 | 24,718 | Albie Lopez | Mike Mussina | Mike Mussina | Albie Lopez | Mariano Rivera | 278 | 460 | -182 |
| 2001-06-23 | vs NYA | 73 | L 1-2 | 21-52 | 5 | 27,816 | Joe Kennedy | Roger Clemens | Roger Clemens | Jeff Wallace | Mariano Rivera | 279 | 462 | -183 |
| 2001-06-24 | vs NYA | 74 | W 5-4 | 22-52 | 5 | 27,999 | Bryan Rekar | Ted Lilly | Travis Phelps | Mike Stanton | | 284 | 466 | -182 |
| 2001-06-25 | @ BOS | 75 | L 8-12 | 22-53 | 5 | 32,854 | Ryan Rupe | David Cone | David Cone | Ryan Rupe | Derek Lowe | 292 | 478 | -186 |
| 2001-06-26 | @ BOS | 76 | L 6-7 | 22-54 | 5 | 32,185 | Tanyon Sturtze | Pedro Martinez | Rod Beck | Victor Zambrano | Derek Lowe | 298 | 485 | -187 |
| 2001-06-27 | @ BOS | 77 | W 9-7 | 23-54 | 5 | 33,216 | Albie Lopez | Hideo Nomo | Doug Creek | Pete Schourek | | 307 | 492 | -185 |
| 2001-06-28 | @ BOS | 78 | W 4-3 | 24-54 | 5 | 33,433 | Joe Kennedy | Frank Castillo | Jesus Colome | Derek Lowe | | 311 | 495 | -184 |
| 2001-06-29 | @ NYA | 79 | L 5-7 | 24-55 | 5 | 38,416 | Bryan Rekar | Roger Clemens | Roger Clemens | Bryan Rekar | Mariano Rivera | 316 | 502 | -186 |
| 2001-06-30 | @ NYA | 80 | L 4-5 | 24-56 | 5 | 42,544 | Ryan Rupe | Ted Lilly | Mike Stanton | Doug Creek | Mariano Rivera | 320 | 507 | -187 |
| 2001-07-01 | @ NYA | 81 | L 1-6 | 24-57 | 5 | 41,983 | Tanyon Sturtze | Andy Pettitte | Andy Pettitte | Tanyon Sturtze | | 321 | 513 | -192 |
| 2001-07-02 | @ NYA | 82 | L 1-7 | 24-58 | 5 | 43,029 | Albie Lopez | Mike Mussina | Mike Mussina | Albie Lopez | | 322 | 520 | -198 |
| 2001-07-03 | vs TOR | 83 | W 7-2 | 25-58 | 5 | 13,789 | Joe Kennedy | Chris Michalak | Joe Kennedy | Chris Michalak | Travis Phelps | 329 | 522 | -193 |
| 2001-07-04 | vs TOR | 84 | L 1-8 | 25-59 | 5 | 13,119 | Bryan Rekar | Steve Parris | Steve Parris | Bryan Rekar | | 330 | 530 | -200 |
| 2001-07-05 | vs TOR | 85 | L 4-7 | 25-60 | 5 | 10,706 | Ryan Rupe | Joey Hamilton | Joey Hamilton | Ryan Rupe | Billy Koch | 334 | 537 | -203 |
| 2001-07-06 | vs FLO | 86 | W 5-4 | 26-60 | 5 | 11,202 | Tanyon Sturtze | A.J. Burnett | Victor Zambrano | Ricky Bones | | 339 | 541 | -202 |
| 2001-07-07 | vs FLO | 87 | W 4-3 | 27-60 | 5 | 16,134 | Albie Lopez | Brad Penny | Albie Lopez | Brad Penny | Travis Phelps | 343 | 544 | -201 |
| 2001-07-08 | vs FLO | 88 | L 1-6 | 27-61 | 5 | 14,712 | Joe Kennedy | Ryan Dempster | Ryan Dempster | Joe Kennedy | | 344 | 550 | -206 |
| 2001-07-12 | @ MON | 89 | W 10-0 | 28-61 | 5 | 4,877 | Tanyon Sturtze | Troy Mattes | Tanyon Sturtze | Troy Mattes | | 354 | 550 | -196 |
| 2001-07-13 | @ MON | 90 | L 2-6 | 28-62 | 5 | 4,277 | Joe Kennedy | Javier Vazquez | Javier Vazquez | Joe Kennedy | | 356 | 556 | -200 |
| 2001-07-14 | @ MON | 91 | L 2-10 | 28-63 | 5 | 5,471 | Bryan Rekar | Tony Armas | Tony Armas | Bryan Rekar | | 358 | 566 | -208 |
| 2001-07-15 | @ ATL | 92 | W 9-1 | 29-63 | 5 | 31,753 | Albie Lopez | Odalis Perez | Albie Lopez | Odalis Perez | | 367 | 567 | -200 |
| 2001-07-16 | @ ATL | 93 | W 6-5 | 30-63 | 5 | 26,197 | Ryan Rupe | Jason Marquis | Victor Zambrano | Steve Karsay | Esteban Yan | 373 | 572 | -199 |
| 2001-07-17 | @ ATL | 94 | L 0-4 | 30-64 | 5 | 32,287 | Tanyon Sturtze | Greg Maddux | Greg Maddux | Tanyon Sturtze | | 373 | 576 | -203 |
| 2001-07-18 | vs ANA | 95 | L 1-2 | 30-65 | 5 | 12,344 | Joe Kennedy | Ismael Valdez | Ismael Valdez | Joe Kennedy | Troy Percival | 374 | 578 | -204 |
| 2001-07-19 | vs ANA | 96 | L 1-2 | 30-66 | 5 | 19,960 | Bryan Rekar | Jarrod Washburn | Jarrod Washburn | Jeff Wallace | Troy Percival | 375 | 580 | -205 |
| 2001-07-20 | vs TEX | 97 | L 1-4 | 30-67 | 5 | 13,611 | Albie Lopez | Doug Davis | Doug Davis | Albie Lopez | Jeff Zimmerman | 376 | 584 | -208 |
| 2001-07-21 | vs TEX | 98 | W 2-1 | 31-67 | 5 | 37,070 | Ryan Rupe | Darren Oliver | Victor Zambrano | Darren Oliver | Esteban Yan | 378 | 585 | -207 |
| 2001-07-22 | vs TEX | 99 | W 7-4 | 32-67 | 5 | 14,732 | Tanyon Sturtze | Rob Bell | Tanyon Sturtze | Juan Moreno | Esteban Yan | 385 | 589 | -204 |
| 2001-07-24 | @ ANA | 100 | L 6-9 | 32-68 | 5 | 16,131 | Joe Kennedy | Jarrod Washburn | Jarrod Washburn | Joe Kennedy | Al Levine | 391 | 598 | -207 |
| 2001-07-25 | @ ANA | 101 | W 3-1 | 33-68 | 5 | 15,718 | Paul Wilson | Matt Wise | Paul Wilson | Matt Wise | Esteban Yan | 394 | 599 | -205 |
| 2001-07-26 | @ ANA | 102 | L 3-5 | 33-69 | 5 | 15,782 | Ryan Rupe | Ramon Ortiz | Ramon Ortiz | Ryan Rupe | Troy Percival | 397 | 604 | -207 |
| 2001-07-27 | @ TEX | 103 | L 7-13 | 33-70 | 5 | 38,213 | Tanyon Sturtze | Rob Bell | Rob Bell | Tanyon Sturtze | | 404 | 617 | -213 |
| 2001-07-28 | @ TEX | 104 | W 7-3 | 34-70 | 5 | 39,023 | Nick Bierbrodt | Aaron Myette | Esteban Yan | Kevin Foster | | 411 | 620 | -209 |
| 2001-07-29 | @ TEX | 105 | L 0-2 | 34-71 | 5 | 28,084 | Joe Kennedy | Rick Helling | Rick Helling | Joe Kennedy | | 411 | 622 | -211 |
| 2001-07-31 | @ BAL | 106 | W 5-4 | 35-71 | 5 | 41,711 | Paul Wilson | Josh Towers | Paul Wilson | Josh Towers | Esteban Yan | 416 | 626 | -210 |
| 2001-08-01 | @ BAL | 107 | L 5-6 | 35-72 | 5 | 33,618 | Ryan Rupe | Jason Johnson | Alan Mills | Esteban Yan | | 421 | 632 | -211 |
| 2001-08-02 | @ BAL | 108 | W 3-2 | 36-72 | 5 | 40,139 | Tanyon Sturtze | Calvin Maduro | Tanyon Sturtze | Calvin Maduro | Victor Zambrano | 424 | 634 | -210 |
| 2001-08-03 | @ CHA | 109 | L 0-4 | 36-73 | 5 | 19,330 | Nick Bierbrodt | Mark Buehrle | Mark Buehrle | Nick Bierbrodt | | 424 | 638 | -214 |
| 2001-08-04 | @ CHA | 110 | L 6-8 | 36-74 | 5 | 28,952 | Joe Kennedy | Sean Lowe | Rocky Biddle | Joe Kennedy | Keith Foulke | 430 | 646 | -216 |
| 2001-08-05 | @ CHA | 111 | W 6-4 | 37-74 | 5 | 21,443 | Paul Wilson | Jon Garland | Victor Zambrano | Bob Howry | Esteban Yan | 436 | 650 | -214 |
| 2001-08-06 | @ CHA | 112 | L 2-5 | 37-75 | 5 | 26,944 | Jeff Wallace | Dan Wright | Dan Wright | Jeff Wallace | Keith Foulke | 438 | 655 | -217 |
| 2001-08-07 | vs NYA | 113 | W 3-2 | 38-75 | 5 | 22,429 | Tanyon Sturtze | Mike Mussina | Tanyon Sturtze | Mike Mussina | Esteban Yan | 441 | 657 | -216 |
| 2001-08-08 | vs NYA | 114 | L 1-16 | 38-76 | 5 | 18,830 | Nick Bierbrodt | Andy Pettitte | Andy Pettitte | Nick Bierbrodt | | 442 | 673 | -231 |
| 2001-08-09 | vs NYA | 115 | L 3-4 | 38-77 | 5 | 21,223 | Jason Standridge | Roger Clemens | Ramiro Mendoza | Esteban Yan | Mariano Rivera | 445 | 677 | -232 |
| 2001-08-10 | vs MIN | 116 | W 4-2 | 39-77 | 5 | 20,112 | Paul Wilson | Joe Mays | Paul Wilson | Joe Mays | | 449 | 679 | -230 |
| 2001-08-11 | vs MIN | 117 | W 4-3 | 40-77 | 5 | 17,576 | Ryan Rupe | Brad Thomas | Ryan Rupe | Brad Thomas | Esteban Yan | 453 | 682 | -229 |
| 2001-08-12 | vs MIN | 118 | W 4-3 | 41-77 | 5 | 20,869 | Tanyon Sturtze | Rick Reed | Victor Zambrano | LaTroy Hawkins | | 457 | 685 | -228 |
| 2001-08-13 | vs MIN | 119 | W 5-1 | 42-77 | 5 | 10,841 | Nick Bierbrodt | Kyle Lohse | Nick Bierbrodt | Kyle Lohse | | 462 | 686 | -224 |
| 2001-08-14 | @ NYA | 120 | L 3-5 | 42-78 | 5 | 34,521 | Joe Kennedy | Andy Pettitte | Andy Pettitte | Joe Kennedy | Mariano Rivera | 465 | 691 | -226 |
| 2001-08-15 | @ NYA | 121 | L 3-10 | 42-79 | 5 | 32,103 | Paul Wilson | Roger Clemens | Roger Clemens | Paul Wilson | | 468 | 701 | -233 |
| 2001-08-16 | @ NYA | 122 | L 5-12 | 42-80 | 5 | 43,600 | Ryan Rupe | Sterling Hitchcock | Sterling Hitchcock | Ryan Rupe | | 473 | 713 | -240 |
| 2001-08-17 | @ MIN | 123 | W 9-4 | 43-80 | 5 | 18,079 | Tanyon Sturtze | Rick Reed | Tanyon Sturtze | Rick Reed | | 482 | 717 | -235 |
| 2001-08-18 | @ MIN | 124 | L 4-6 | 43-81 | 5 | 30,018 | Nick Bierbrodt | Kyle Lohse | Kyle Lohse | Nick Bierbrodt | Todd Jones | 486 | 723 | -237 |
| 2001-08-19 | @ MIN | 125 | W 5-1 | 44-81 | 5 | 35,287 | Joe Kennedy | Eric Milton | Joe Kennedy | Eric Milton | | 491 | 724 | -233 |
| 2001-08-21 | vs BAL | 126 | W 8-4 | 45-81 | 5 | 13,247 | Paul Wilson | Jose Mercedes | Travis Phelps | Jose Mercedes | | 499 | 728 | -229 |
| 2001-08-22 | vs BAL | 127 | W 11-10 | 46-81 | 5 | 12,113 | Ryan Rupe | Sidney Ponson | Esteban Yan | Willis Roberts | | 510 | 738 | -228 |
| 2001-08-23 | vs BAL | 128 | L 4-7 | 46-82 | 5 | 29,018 | Nick Bierbrodt | Josh Towers | Jorge Julio | Victor Zambrano | Willis Roberts | 514 | 745 | -231 |
| 2001-08-24 | vs CHA | 129 | L 4-5 | 46-83 | 5 | 10,650 | Tanyon Sturtze | Mark Buehrle | Mark Buehrle | Tanyon Sturtze | Keith Foulke | 518 | 750 | -232 |
| 2001-08-25 | vs CHA | 130 | W 8-4 | 47-83 | 5 | 26,597 | Joe Kennedy | Dan Wright | Joe Kennedy | Dan Wright | | 526 | 754 | -228 |
| 2001-08-26 | vs CHA | 131 | L 2-3 | 47-84 | 5 | 19,182 | Bryan Rekar | Jon Garland | Jon Garland | Bobby Seay | Keith Foulke | 528 | 757 | -229 |
| 2001-08-28 | vs SEA | 132 | W 6-0 | 48-84 | 5 | 11,687 | Paul Wilson | Joel Pineiro | Paul Wilson | Joel Pineiro | | 534 | 757 | -223 |
| 2001-08-29 | vs SEA | 133 | L 2-5 | 48-85 | 5 | 12,792 | Tanyon Sturtze | Jamie Moyer | Jamie Moyer | Tanyon Sturtze | | 536 | 762 | -226 |
| 2001-08-30 | vs SEA | 134 | L 0-4 | 48-86 | 5 | 12,260 | Ryan Rupe | Freddy Garcia | Freddy Garcia | Ryan Rupe | | 536 | 766 | -230 |
| 2001-08-31 | vs OAK | 135 | L 5-9 | 48-87 | 5 | 11,230 | Bryan Rekar | Cory Lidle | Cory Lidle | Bryan Rekar | | 541 | 775 | -234 |
| 2001-09-01 | vs OAK | 136 | W 8-6 | 49-87 | 5 | 15,944 | Nick Bierbrodt | Erik Hiljus | Bobby Seay | Jeff Tam | Esteban Yan | 549 | 781 | -232 |
| 2001-09-02 | vs OAK | 137 | L 1-3 | 49-88 | 5 | 14,634 | Joe Kennedy | Mark Mulder | Mark Mulder | Doug Creek | | 550 | 784 | -234 |
| 2001-09-03 | @ SEA | 138 | L 2-3 | 49-89 | 5 | 45,728 | Paul Wilson | Jamie Moyer | Norm Charlton | Esteban Yan | | 552 | 787 | -235 |
| 2001-09-04 | @ SEA | 139 | W 8-3 | 50-89 | 5 | 44,859 | Tanyon Sturtze | Freddy Garcia | Victor Zambrano | Norm Charlton | | 560 | 790 | -230 |
| 2001-09-05 | @ SEA | 140 | L 6-12 | 50-90 | 5 | 44,720 | Ryan Rupe | Aaron Sele | John Halama | Travis Phelps | | 566 | 802 | -236 |
| 2001-09-07 | @ OAK | 141 | L 3-9 | 50-91 | 5 | 15,037 | Bryan Rekar | Erik Hiljus | Erik Hiljus | Bryan Rekar | | 569 | 811 | -242 |
| 2001-09-08 | @ OAK | 142 | L 4-10 | 50-92 | 5 | 32,548 | Nick Bierbrodt | Mark Mulder | Mark Mulder | Nick Bierbrodt | | 573 | 821 | -248 |
| 2001-09-09 | @ OAK | 143 | L 3-4 | 50-93 | 5 | 18,871 | Joe Kennedy | Tim Hudson | Luis Vizcaino | Jesus Colome | | 576 | 825 | -249 |
| 2001-09-18 | @ BOS | 144 | L 2-7 | 50-94 | 5 | 30,909 | Tanyon Sturtze | Hideo Nomo | Hideo Nomo | Tanyon Sturtze | | 578 | 832 | -254 |
| 2001-09-19 | @ BOS | 145 | W 12-2 | 51-94 | 5 | 29,627 | Paul Wilson | David Cone | Paul Wilson | David Cone | | 590 | 834 | -244 |
| 2001-09-20 | @ BOS | 146 | L 1-2 | 51-95 | 5 | 29,530 | Ryan Rupe | Frank Castillo | Rolando Arrojo | Doug Creek | Rod Beck | 591 | 836 | -245 |
| 2001-09-21 | @ TOR | 147 | W 7-4 | 52-95 | 5 | 25,344 | Bryan Rekar | Brandon Lyon | Bryan Rekar | Brandon Lyon | Esteban Yan | 598 | 840 | -242 |
| 2001-09-22 | @ TOR | 148 | L 7-8 | 52-96 | 5 | 24,691 | Nick Bierbrodt | Esteban Loaiza | Pasqual Coco | Jesus Colome | Billy Koch | 605 | 848 | -243 |
| 2001-09-23 | @ TOR | 149 | W 1-0 | 53-96 | 5 | 31,351 | Joe Kennedy | Kelvim Escobar | Joe Kennedy | Kelvim Escobar | Esteban Yan | 606 | 848 | -242 |
| 2001-09-25 | @ NYA | 150 | W 4-0 | 54-96 | 5 | 33,777 | Tanyon Sturtze | Roger Clemens | Tanyon Sturtze | Roger Clemens | | 610 | 848 | -238 |
| 2001-09-26 | @ NYA | 151 | L 1-5 | 54-97 | 5 | 23,352 | Paul Wilson | Andy Pettitte | Ted Lilly | Paul Wilson | | 611 | 853 | -242 |
| 2001-09-27 | vs TOR | 152 | W 5-1 | 55-97 | 5 | 13,045 | Ryan Rupe | Brandon Lyon | Jesus Colome | Scott Eyre | | 616 | 854 | -238 |
| 2001-09-28 | vs TOR | 153 | W 6-1 | 56-97 | 5 | 10,586 | Bryan Rekar | Kelvim Escobar | Bryan Rekar | Kelvim Escobar | Travis Phelps | 622 | 855 | -233 |
| 2001-09-29 | vs TOR | 154 | W 5-2 | 57-97 | 5 | 17,635 | Nick Bierbrodt | Roy Halladay | Nick Bierbrodt | Roy Halladay | Esteban Yan | 627 | 857 | -230 |
| 2001-09-30 | vs TOR | 155 | L 5-6 | 57-98 | 5 | 14,217 | Joe Kennedy | Chris Carpenter | Paul Quantrill | Doug Creek | Scott Eyre | 632 | 863 | -231 |
| 2001-10-01 | vs BOS | 156 | W 10-3 | 58-98 | 5 | 10,775 | Tanyon Sturtze | David Cone | Tanyon Sturtze | David Cone | | 642 | 866 | -224 |
| 2001-10-02 | vs BOS | 157 | W 10-3 | 59-98 | 5 | 11,266 | Paul Wilson | Casey Fossum | Paul Wilson | Casey Fossum | | 652 | 869 | -217 |
| 2001-10-03 | vs BOS | 158 | L 3-10 | 59-99 | 5 | 10,985 | Ryan Rupe | Derek Lowe | Derek Lowe | Ryan Rupe | Tim Wakefield | 655 | 879 | -224 |
| 2001-10-04 | vs NYA | 159 | W 4-1 | 60-99 | 5 | 15,265 | Nick Bierbrodt | Adrian Hernandez | Nick Bierbrodt | Adrian Hernandez | Esteban Yan | 659 | 880 | -221 |
| 2001-10-05 | vs NYA | 160 | W 8-4 | 61-99 | 5 | 22,028 | Joe Kennedy | Roger Clemens | Joe Kennedy | Roger Clemens | Victor Zambrano | 667 | 884 | -217 |
| 2001-10-06 | vs NYA | 161 | W 5-2 | 62-99 | 5 | 25,511 | Tanyon Sturtze | Andy Pettitte | Tanyon Sturtze | Ramiro Mendoza | Esteban Yan | 672 | 886 | -214 |
| 2001-10-07 | vs NYA | 162 | L 0-1 | 62-100 | 5 | 24,075 | Paul Wilson | Mike Mussina | Orlando Hernandez | Jesus Colome | Mariano Rivera | 672 | 887 | -215 |