| 2001-04-02 | @ COL | 1 | L 0-8 | 0-1 | 6 | 48,113 | Darryl Kile | Mike Hampton | Mike Hampton | Darryl Kile | | 0 | 8 | -8 |
| 2001-04-04 | @ COL | 2 | L 9-13 | 0-2 | 6 | 36,667 | Andy Benes | Denny Neagle | Denny Neagle | Andy Benes | Jose Jimenez | 9 | 21 | -12 |
| 2001-04-05 | @ COL | 3 | L 2-11 | 0-3 | 6 | 35,142 | Matt Morris | Pedro Astacio | Pedro Astacio | Matt Morris | | 11 | 32 | -21 |
| 2001-04-06 | @ ARI | 4 | W 12-9 | 1-3 | 5 | 46,079 | Dustin Hermanson | Armando Reynoso | Dustin Hermanson | Armando Reynoso | | 23 | 41 | -18 |
| 2001-04-07 | @ ARI | 5 | W 8-4 | 2-3 | 4 | 34,404 | Darryl Kile | Bobby Witt | Darryl Kile | Bobby Witt | | 31 | 45 | -14 |
| 2001-04-08 | @ ARI | 6 | W 9-4 | 3-3 | 4 | 36,714 | Rick Ankiel | Randy Johnson | Rick Ankiel | Randy Johnson | Mike Timlin | 40 | 49 | -9 |
| 2001-04-09 | vs COL | 7 | W 3-2 | 4-3 | 2 | 48,702 | Andy Benes | Denny Neagle | Mike Timlin | Gabe White | | 43 | 51 | -8 |
| 2001-04-11 | vs COL | 8 | W 3-1 | 5-3 | 2 | 30,115 | Matt Morris | Pedro Astacio | Matt Morris | Pedro Astacio | Dave Veres | 46 | 52 | -6 |
| 2001-04-12 | vs COL | 9 | L 4-6 | 5-4 | 3 | 35,127 | Dustin Hermanson | Mike Hampton | John Wasdin | Steve Kline | Jose Jimenez | 50 | 58 | -8 |
| 2001-04-13 | vs HOU | 10 | L 2-4 | 5-5 | 3 | 42,153 | Darryl Kile | Kent Bottenfield | Kent Bottenfield | Darryl Kile | Billy Wagner | 52 | 62 | -10 |
| 2001-04-14 | vs HOU | 11 | L 4-7 | 5-6 | 4 | 39,235 | Rick Ankiel | Scott Elarton | Scott Elarton | Rick Ankiel | Billy Wagner | 56 | 69 | -13 |
| 2001-04-15 | vs HOU | 12 | W 6-5 | 6-6 | 4 | 27,993 | Andy Benes | Jose Lima | Mike James | Jay Powell | Steve Kline | 62 | 74 | -12 |
| 2001-04-16 | vs ARI | 13 | L 1-2 | 6-7 | 5 | 25,625 | Matt Morris | Robert Ellis | Robert Ellis | Matt Morris | Matt Mantei | 63 | 76 | -13 |
| 2001-04-17 | vs ARI | 14 | L 4-17 | 6-8 | 5 | 28,517 | Dustin Hermanson | Armando Reynoso | Armando Reynoso | Dustin Hermanson | | 67 | 93 | -26 |
| 2001-04-18 | vs ARI | 15 | W 3-1 | 7-8 | 5 | 29,144 | Darryl Kile | Randy Johnson | Darryl Kile | Randy Johnson | Steve Kline | 70 | 94 | -24 |
| 2001-04-20 | @ HOU | 16 | L 1-10 | 7-9 | 5 | 39,152 | Rick Ankiel | Scott Elarton | Scott Elarton | Rick Ankiel | | 71 | 104 | -33 |
| 2001-04-21 | @ HOU | 17 | W 9-2 | 8-9 | 5 | 40,981 | Matt Morris | Jose Lima | Matt Morris | Jose Lima | | 80 | 106 | -26 |
| 2001-04-22 | @ HOU | 18 | L 3-4 | 8-10 | 5 | 31,020 | Dustin Hermanson | Wade Miller | Wade Miller | Gene Stechschulte | Billy Wagner | 83 | 110 | -27 |
| 2001-04-24 | vs MON | 19 | W 7-2 | 9-10 | 5 | 28,345 | Darryl Kile | Javier Vazquez | Darryl Kile | Javier Vazquez | | 90 | 112 | -22 |
| 2001-04-25 | vs MON | 20 | W 5-2 | 10-10 | 5 | 28,858 | Andy Benes | Britt Reames | Andy Benes | Britt Reames | Gene Stechschulte | 95 | 114 | -19 |
| 2001-04-26 | vs MON | 21 | L 3-4 | 10-11 | 5 | 42,373 | Rick Ankiel | Tony Armas | Masato Yoshii | Mike James | | 98 | 118 | -20 |
| 2001-04-27 | vs NYN | 22 | W 9-0 | 11-11 | 5 | 40,674 | Matt Morris | Kevin Appier | Matt Morris | Kevin Appier | | 107 | 118 | -11 |
| 2001-04-28 | vs NYN | 23 | L 5-6 | 11-12 | 5 | 43,843 | Dustin Hermanson | Rick Reed | Armando Benitez | Mike James | | 112 | 124 | -12 |
| 2001-04-29 | vs NYN | 24 | W 12-1 | 12-12 | 5 | 38,401 | Darryl Kile | Glendon Rusch | Darryl Kile | Glendon Rusch | | 124 | 125 | -1 |
| 2001-05-01 | @ FLO | 25 | L 3-4 | 12-13 | 5 | 10,377 | Andy Benes | Jason Grilli | Vladimir Nunez | Andy Benes | Antonio Alfonseca | 127 | 129 | -2 |
| 2001-05-02 | @ FLO | 26 | W 4-2 | 13-13 | 5 | 10,308 | Matt Morris | Brad Penny | Steve Kline | Antonio Alfonseca | Dave Veres | 131 | 131 | 0 |
| 2001-05-04 | @ ATL | 27 | W 4-2 | 14-13 | 5 | 40,981 | Dustin Hermanson | Tom Glavine | Dustin Hermanson | Tom Glavine | Dave Veres | 135 | 133 | 2 |
| 2001-05-05 | @ ATL | 28 | L 5-6 | 14-14 | 5 | 48,543 | Rick Ankiel | Odalis Perez | Mike Remlinger | Mike Timlin | John Rocker | 140 | 139 | 1 |
| 2001-05-06 | @ ATL | 29 | L 5-7 | 14-15 | 5 | 44,144 | Darryl Kile | Kevin Millwood | Jose Cabrera | Gene Stechschulte | John Rocker | 145 | 146 | -1 |
| 2001-05-07 | vs PIT | 30 | W 7-0 | 15-15 | 5 | 31,891 | Matt Morris | Todd Ritchie | Matt Morris | Todd Ritchie | | 152 | 146 | 6 |
| 2001-05-08 | vs PIT | 31 | W 8-2 | 16-15 | 4 | 35,771 | Andy Benes | Jimmy Anderson | Andy Benes | Jimmy Anderson | | 160 | 148 | 12 |
| 2001-05-09 | vs PIT | 32 | W 6-2 | 17-15 | 3 | 33,921 | Dustin Hermanson | Bronson Arroyo | Dustin Hermanson | Bronson Arroyo | | 166 | 150 | 16 |
| 2001-05-10 | vs PIT | 33 | W 11-5 | 18-15 | 2 | 45,008 | Rick Ankiel | Omar Olivares | Mike Matthews | Jose Silva | | 177 | 155 | 22 |
| 2001-05-11 | vs CHN | 34 | W 7-2 | 19-15 | 2 | 47,444 | Darryl Kile | Jason Bere | Darryl Kile | Jason Bere | | 184 | 157 | 27 |
| 2001-05-12 | vs CHN | 35 | W 5-2 | 20-15 | 2 | 46,885 | Matt Morris | Jon Lieber | Matt Morris | Jon Lieber | Dave Veres | 189 | 159 | 30 |
| 2001-05-13 | vs CHN | 36 | W 13-4 | 21-15 | 1 | 46,167 | Andy Benes | Kerry Wood | Andy Benes | Kerry Wood | | 202 | 163 | 39 |
| 2001-05-15 | @ PIT | 37 | W 8-3 | 22-15 | 1 | 30,883 | Dustin Hermanson | Omar Olivares | Dustin Hermanson | Omar Olivares | | 210 | 166 | 44 |
| 2001-05-16 | @ PIT | 38 | W 3-0 | 23-15 | 1 | 29,128 | Darryl Kile | Jason Schmidt | Darryl Kile | Jason Schmidt | | 213 | 166 | 47 |
| 2001-05-17 | @ PIT | 39 | W 12-2 | 24-15 | 1 | 29,835 | Matt Morris | Todd Ritchie | Matt Morris | Todd Ritchie | | 225 | 168 | 57 |
| 2001-05-18 | @ PHI | 40 | L 4-5 | 24-16 | 1 | 17,085 | Mike Matthews | Omar Daal | Omar Daal | Mike Timlin | Jose Mesa | 229 | 173 | 56 |
| 2001-05-19 | @ PHI | 41 | L 2-3 | 24-17 | 2 | 24,499 | Andy Benes | Robert Person | Robert Person | Andy Benes | | 231 | 176 | 55 |
| 2001-05-20 | @ PHI | 42 | W 3-1 | 25-17 | 1 | 31,391 | Dustin Hermanson | Amaury Telemaco | Dustin Hermanson | Amaury Telemaco | Dave Veres | 234 | 177 | 57 |
| 2001-05-22 | @ MIL | 43 | L 0-5 | 25-18 | 1 | 30,200 | Darryl Kile | Jimmy Haynes | Jimmy Haynes | Darryl Kile | | 234 | 182 | 52 |
| 2001-05-23 | @ MIL | 44 | L 3-7 | 25-19 | 1 | 34,613 | Matt Morris | Paul Rigdon | Paul Rigdon | Matt Morris | | 237 | 189 | 48 |
| 2001-05-24 | @ MIL | 45 | W 7-4 | 26-19 | 1 | 40,313 | Mike Matthews | Ben Sheets | Mike Matthews | Ben Sheets | | 244 | 193 | 51 |
| 2001-05-25 | @ CIN | 46 | W 5-4 | 27-19 | 1 | 24,590 | Andy Benes | Chris Reitsma | Alan Benes | Danny Graves | Dave Veres | 249 | 197 | 52 |
| 2001-05-26 | @ CIN | 47 | L 2-7 | 27-20 | 2 | 34,158 | Dustin Hermanson | Elmer Dessens | Elmer Dessens | Dustin Hermanson | | 251 | 204 | 47 |
| 2001-05-27 | @ CIN | 48 | W 2-0 | 28-20 | 2 | 28,140 | Darryl Kile | Brian Reith | Darryl Kile | Brian Reith | Dave Veres | 253 | 204 | 49 |
| 2001-05-28 | vs MIL | 49 | W 6-2 | 29-20 | 2 | 42,455 | Matt Morris | Paul Rigdon | Matt Morris | Paul Rigdon | Jason Christiansen | 259 | 206 | 53 |
| 2001-05-29 | vs MIL | 50 | L 0-7 | 29-21 | 2 | 39,088 | Mike Matthews | Ben Sheets | Ben Sheets | Mike Matthews | | 259 | 213 | 46 |
| 2001-05-30 | vs MIL | 51 | L 1-11 | 29-22 | 2 | 29,842 | Andy Benes | Allen Levrault | Allen Levrault | Andy Benes | | 260 | 224 | 36 |
| 2001-05-31 | vs MIL | 52 | L 2-6 | 29-23 | 2 | 30,928 | Dustin Hermanson | Kyle Peterson | Kyle Peterson | Dustin Hermanson | | 262 | 230 | 32 |
| 2001-06-01 | vs CIN | 53 | L 1-5 | 29-24 | 2 | 41,593 | Darryl Kile | Elmer Dessens | Hector Mercado | Darryl Kile | Danny Graves | 263 | 235 | 28 |
| 2001-06-02 | vs CIN | 54 | W 8-5 | 30-24 | 2 | 46,724 | Matt Morris | Brian Reith | Matt Morris | Brian Reith | Gene Stechschulte | 271 | 240 | 31 |
| 2001-06-03 | vs CIN | 55 | W 4-3 | 31-24 | 2 | 42,903 | Mike Matthews | Rob Bell | Mike Timlin | Rob Bell | Dave Veres | 275 | 243 | 32 |
| 2001-06-04 | vs CIN | 56 | W 5-2 | 32-24 | 2 | 34,014 | Andy Benes | Osvaldo Fernandez | Andy Benes | Osvaldo Fernandez | Dave Veres | 280 | 245 | 35 |
| 2001-06-05 | @ CHN | 57 | L 6-12 | 32-25 | 2 | 37,912 | Dustin Hermanson | Jon Lieber | Jon Lieber | Dustin Hermanson | | 286 | 257 | 29 |
| 2001-06-06 | @ CHN | 58 | L 1-4 | 32-26 | 2 | 34,484 | Darryl Kile | Kerry Wood | Kerry Wood | Darryl Kile | Tom Gordon | 287 | 261 | 26 |
| 2001-06-07 | @ CHN | 59 | L 3-4 | 32-27 | 2 | 37,359 | Matt Morris | Kevin Tapani | Jeff Fassero | Mike Timlin | | 290 | 265 | 25 |
| 2001-06-08 | @ COL | 60 | L 1-9 | 32-28 | 2 | 46,188 | Mike Matthews | Denny Neagle | Denny Neagle | Mike Matthews | | 291 | 274 | 17 |
| 2001-06-09 | @ COL | 61 | W 8-2 | 33-28 | 2 | 47,043 | Andy Benes | Pedro Astacio | Andy Benes | Pedro Astacio | | 299 | 276 | 23 |
| 2001-06-10 | @ COL | 62 | L 3-12 | 33-29 | 2 | 47,139 | Dustin Hermanson | Mike Hampton | Mike Hampton | Dustin Hermanson | | 302 | 288 | 14 |
| 2001-06-12 | @ KCA | 63 | L 4-7 | 33-30 | 2 | 27,914 | Darryl Kile | Chad Durbin | Chad Durbin | Darryl Kile | | 306 | 295 | 11 |
| 2001-06-13 | @ KCA | 64 | L 1-4 | 33-31 | 2 | 28,382 | Matt Morris | Kris Wilson | Kris Wilson | Matt Morris | Roberto Hernandez | 307 | 299 | 8 |
| 2001-06-14 | @ KCA | 65 | L 2-3 | 33-32 | 4 | 37,377 | Mike Matthews | Jeff Suppan | Doug Henry | Gene Stechschulte | | 309 | 302 | 7 |
| 2001-06-15 | vs CHA | 66 | W 10-3 | 34-32 | 2 | 42,741 | Andy Benes | Jon Garland | Andy Benes | Jon Garland | | 319 | 305 | 14 |
| 2001-06-16 | vs CHA | 67 | W 8-3 | 35-32 | 2 | 43,648 | Dustin Hermanson | Kip Wells | Dustin Hermanson | Kip Wells | | 327 | 308 | 19 |
| 2001-06-17 | vs CHA | 68 | W 8-3 | 36-32 | 2 | 41,515 | Bud Smith | David Wells | Bud Smith | David Wells | | 335 | 311 | 24 |
| 2001-06-18 | vs CHN | 69 | W 6-2 | 37-32 | 2 | 40,016 | Darryl Kile | Kevin Tapani | Darryl Kile | Kevin Tapani | | 341 | 313 | 28 |
| 2001-06-19 | vs CHN | 70 | W 3-2 | 38-32 | 2 | 40,715 | Matt Morris | Jason Bere | Matt Morris | Kyle Farnsworth | Dave Veres | 344 | 315 | 29 |
| 2001-06-20 | vs CHN | 71 | L 4-9 | 38-33 | 2 | 41,968 | Mike Matthews | Julian Tavarez | Julian Tavarez | Mike Matthews | | 348 | 324 | 24 |
| 2001-06-21 | vs CHN | 72 | L 2-5 | 38-34 | 2 | 47,950 | Andy Benes | Jon Lieber | Jon Lieber | Andy Benes | Tom Gordon | 350 | 329 | 21 |
| 2001-06-22 | vs SFN | 73 | L 5-10 | 38-35 | 2 | 40,845 | Dustin Hermanson | Livan Hernandez | Livan Hernandez | Dustin Hermanson | | 355 | 339 | 16 |
| 2001-06-23 | vs SFN | 74 | W 6-5 | 39-35 | 2 | 48,517 | Darryl Kile | Kirk Rueter | Jason Christiansen | Alan Embree | | 361 | 344 | 17 |
| 2001-06-24 | vs SFN | 75 | W 7-3 | 40-35 | 2 | 48,203 | Matt Morris | Russ Ortiz | Matt Morris | Russ Ortiz | Dave Veres | 368 | 347 | 21 |
| 2001-06-26 | vs CIN | 76 | L 9-10 | 40-36 | 3 | 41,791 | Andy Benes | Chris Reitsma | Scott Sullivan | Gene Stechschulte | Danny Graves | 377 | 357 | 20 |
| 2001-06-27 | vs CIN | 77 | L 1-3 | 40-37 | 3 | 35,845 | Dustin Hermanson | Lance Davis | Lance Davis | Dustin Hermanson | Danny Graves | 378 | 360 | 18 |
| 2001-06-29 | @ SFN | 78 | L 2-3 | 40-38 | 3 | 41,738 | Darryl Kile | Kirk Rueter | Felix Rodriguez | Steve Kline | Robb Nen | 380 | 363 | 17 |
| 2001-06-30 | @ SFN | 79 | L 2-5 | 40-39 | 3 | 41,341 | Matt Morris | Russ Ortiz | Felix Rodriguez | Mike Timlin | Robb Nen | 382 | 368 | 14 |
| 2001-07-01 | @ SFN | 80 | L 4-5 | 40-40 | 3 | 41,705 | Andy Benes | Mark Gardner | Chad Zerbe | Andy Benes | Robb Nen | 386 | 373 | 13 |
| 2001-07-03 | @ MIL | 81 | L 0-2 | 40-41 | 4 | 38,375 | Dustin Hermanson | Jamey Wright | Jamey Wright | Steve Kline | David Weathers | 386 | 375 | 11 |
| 2001-07-04 | @ MIL | 82 | W 7-2 | 41-41 | 3 | 31,572 | Mike Matthews | Ben Sheets | Mike Matthews | Ben Sheets | | 393 | 377 | 16 |
| 2001-07-05 | @ MIL | 83 | W 5-2 | 42-41 | 3 | 42,586 | Darryl Kile | Kyle Peterson | Darryl Kile | Kyle Peterson | Mike Timlin | 398 | 379 | 19 |
| 2001-07-06 | @ CLE | 84 | L 2-14 | 42-42 | 3 | 42,394 | Matt Morris | Charles Nagy | Charles Nagy | Matt Morris | | 400 | 393 | 7 |
| 2001-07-07 | @ CLE | 85 | L 6-7 | 42-43 | 3 | 42,467 | Andy Benes | CC Sabathia | John Rocker | Dave Veres | | 406 | 400 | 6 |
| 2001-07-08 | @ CLE | 86 | W 4-3 | 43-43 | 3 | 42,431 | Dustin Hermanson | Jake Westbrook | Mike Timlin | John Rocker | | 410 | 403 | 7 |
| 2001-07-12 | vs DET | 87 | L 5-7 | 43-44 | 3 | 35,554 | Darryl Kile | Jeff Weaver | Jeff Weaver | Darryl Kile | Matt Anderson | 415 | 410 | 5 |
| 2001-07-13 | vs DET | 88 | L 1-4 | 43-45 | 4 | 38,667 | Mike Matthews | Steve Sparks | Steve Sparks | Mike Matthews | | 416 | 414 | 2 |
| 2001-07-14 | vs DET | 89 | W 3-2 | 44-45 | 3 | 47,176 | Matt Morris | Jose Lima | Matt Morris | Jose Lima | Steve Kline | 419 | 416 | 3 |
| 2001-07-15 | vs MIN | 90 | W 5-1 | 45-45 | 3 | 44,593 | Dustin Hermanson | Joe Mays | Dustin Hermanson | Joe Mays | | 424 | 417 | 7 |
| 2001-07-16 | vs MIN | 91 | W 4-3 | 46-45 | 3 | 40,042 | Bud Smith | Adam Johnson | Steve Kline | Travis Miller | Jason Christiansen | 428 | 420 | 8 |
| 2001-07-17 | vs MIN | 92 | W 4-2 | 47-45 | 3 | 40,847 | Darryl Kile | Kyle Lohse | Darryl Kile | Kyle Lohse | Jason Christiansen | 432 | 422 | 10 |
| 2001-07-18 | @ HOU | 93 | L 11-17 | 47-46 | 3 | 33,016 | Mike Matthews | Roy Oswalt | Ron Villone | Luther Hackman | | 443 | 439 | 4 |
| 2001-07-19 | @ HOU | 94 | W 4-1 | 48-46 | 3 | 38,523 | Matt Morris | Wade Miller | Matt Morris | Wade Miller | Mike Timlin | 447 | 440 | 7 |
| 2001-07-20 | vs PIT | 95 | L 1-4 | 48-47 | 3 | 35,215 | Dustin Hermanson | Jason Schmidt | Jason Schmidt | Dustin Hermanson | Josias Manzanillo | 448 | 444 | 4 |
| 2001-07-21 | vs PIT | 96 | W 9-2 | 49-47 | 3 | 44,930 | Bud Smith | Joe Beimel | Bud Smith | Joe Beimel | | 457 | 446 | 11 |
| 2001-07-22 | vs PIT | 97 | L 0-2 | 49-48 | 3 | 33,546 | Darryl Kile | Jimmy Anderson | Jimmy Anderson | Mike Timlin | Mike Williams | 457 | 448 | 9 |
| 2001-07-24 | vs HOU | 98 | L 1-2 | 49-49 | 3 | 37,307 | Matt Morris | Wade Miller | Wade Miller | Matt Morris | Billy Wagner | 458 | 450 | 8 |
| 2001-07-25 | vs HOU | 99 | W 10-2 | 50-49 | 3 | 36,685 | Dustin Hermanson | Tim Redding | Dustin Hermanson | Tim Redding | | 468 | 452 | 16 |
| 2001-07-26 | @ CHN | 100 | W 3-1 | 51-49 | 3 | 38,549 | Bud Smith | Kevin Tapani | Bud Smith | Kevin Tapani | Steve Kline | 471 | 453 | 18 |
| 2001-07-27 | @ CHN | 101 | L 3-4 | 51-50 | 3 | 40,125 | Darryl Kile | Jason Bere | Jeff Fassero | Jason Christiansen | Tom Gordon | 474 | 457 | 17 |
| 2001-07-28 | @ CHN | 102 | W 7-4 | 52-50 | 3 | 40,266 | Andy Benes | Kerry Wood | Dave Veres | Mike Fyhrie | Steve Kline | 481 | 461 | 20 |
| 2001-07-29 | @ CHN | 103 | L 5-7 | 52-51 | 3 | 40,295 | Matt Morris | Julian Tavarez | Julian Tavarez | Matt Morris | Tom Gordon | 486 | 468 | 18 |
| 2001-07-31 | vs ATL | 104 | W 6-2 | 53-51 | 3 | 39,012 | Dustin Hermanson | Kevin Millwood | Dustin Hermanson | Steve Reed | | 492 | 470 | 22 |
| 2001-08-01 | vs ATL | 105 | W 4-0 | 54-51 | 3 | 37,633 | Darryl Kile | Greg Maddux | Darryl Kile | Greg Maddux | | 496 | 470 | 26 |
| 2001-08-02 | vs ATL | 106 | L 1-2 | 54-52 | 3 | 38,394 | Bud Smith | Tom Glavine | Tom Glavine | Bud Smith | Steve Karsay | 497 | 472 | 25 |
| 2001-08-03 | vs FLO | 107 | W 9-5 | 55-53 | 3 | 0 | Matt Morris | Brad Penny | Matt Morris | Brad Penny | Steve Kline | 506 | 477 | 29 |
| 2001-08-03 | vs FLO | 108 | L 4-6 | 55-53 | 3 | 38,910 | Andy Benes | Jesus Sanchez | Vladimir Nunez | Dave Veres | Antonio Alfonseca | 510 | 483 | 27 |
| 2001-08-04 | vs FLO | 109 | W 3-0 | 56-53 | 3 | 42,312 | Woody Williams | A.J. Burnett | Woody Williams | A.J. Burnett | Gene Stechschulte | 513 | 483 | 30 |
| 2001-08-05 | vs FLO | 110 | L 3-5 | 56-54 | 3 | 33,711 | Dustin Hermanson | Ryan Dempster | Ryan Dempster | Dustin Hermanson | Antonio Alfonseca | 516 | 488 | 28 |
| 2001-08-07 | @ MON | 111 | W 3-1 | 57-54 | 3 | 7,760 | Darryl Kile | Javier Vazquez | Darryl Kile | Javier Vazquez | | 519 | 489 | 30 |
| 2001-08-08 | @ MON | 112 | L 5-6 | 57-55 | 3 | 6,611 | Bud Smith | Tony Armas | Masato Yoshii | Luther Hackman | | 524 | 495 | 29 |
| 2001-08-09 | @ MON | 113 | W 9-6 | 58-55 | 3 | 7,166 | Matt Morris | Tomo Ohka | Matt Morris | Tomo Ohka | | 533 | 501 | 32 |
| 2001-08-10 | @ NYN | 114 | W 7-6 | 59-55 | 3 | 32,844 | Woody Williams | Kevin Appier | Dave Veres | Rick White | Steve Kline | 540 | 507 | 33 |
| 2001-08-11 | @ NYN | 115 | W 6-3 | 60-55 | 3 | 38,837 | Dustin Hermanson | Glendon Rusch | Dustin Hermanson | Glendon Rusch | Dave Veres | 546 | 510 | 36 |
| 2001-08-12 | @ NYN | 116 | W 4-1 | 61-55 | 3 | 38,939 | Darryl Kile | Bruce Chen | Darryl Kile | Bruce Chen | Dave Veres | 550 | 511 | 39 |
| 2001-08-13 | vs CIN | 117 | W 3-2 | 62-55 | 3 | 32,929 | Bud Smith | Elmer Dessens | Andy Benes | Elmer Dessens | Dave Veres | 553 | 513 | 40 |
| 2001-08-14 | vs CIN | 118 | W 7-1 | 63-55 | 3 | 32,226 | Matt Morris | Dennys Reyes | Matt Morris | Dennys Reyes | | 560 | 514 | 46 |
| 2001-08-15 | vs CIN | 119 | W 8-4 | 64-55 | 3 | 32,151 | Woody Williams | Chris Reitsma | Woody Williams | Chris Reitsma | | 568 | 518 | 50 |
| 2001-08-16 | vs CIN | 120 | W 8-3 | 65-55 | 3 | 32,431 | Dustin Hermanson | Jose Acevedo | Dustin Hermanson | Jose Acevedo | | 576 | 521 | 55 |
| 2001-08-17 | vs PHI | 121 | W 4-3 | 66-55 | 3 | 38,431 | Darryl Kile | Robert Person | Dave Veres | Turk Wendell | | 580 | 524 | 56 |
| 2001-08-18 | vs PHI | 122 | W 6-3 | 67-55 | 3 | 45,437 | Bud Smith | Brandon Duckworth | Steve Kline | Cliff Politte | Dave Veres | 586 | 527 | 59 |
| 2001-08-19 | vs PHI | 123 | W 9-0 | 68-55 | 3 | 38,265 | Matt Morris | Dave Coggin | Matt Morris | Dave Coggin | | 595 | 527 | 68 |
| 2001-08-20 | @ CIN | 124 | L 4-5 | 68-56 | 3 | 19,323 | Woody Williams | Chris Reitsma | John Riedling | Andy Benes | | 599 | 532 | 67 |
| 2001-08-21 | @ CIN | 125 | W 11-6 | 69-56 | 3 | 19,571 | Dustin Hermanson | Jose Acevedo | Dustin Hermanson | Jose Acevedo | | 610 | 538 | 72 |
| 2001-08-22 | @ CIN | 126 | L 1-3 | 69-57 | 3 | 19,334 | Darryl Kile | Lance Davis | Lance Davis | Darryl Kile | Danny Graves | 611 | 541 | 70 |
| 2001-08-23 | @ CIN | 127 | L 2-12 | 69-58 | 3 | 23,887 | Bud Smith | Elmer Dessens | Elmer Dessens | Bud Smith | | 613 | 553 | 60 |
| 2001-08-24 | @ CHN | 128 | W 10-8 | 70-58 | 3 | 39,357 | Matt Morris | Jason Bere | Matt Morris | Jason Bere | Luther Hackman | 623 | 561 | 62 |
| 2001-08-25 | @ CHN | 129 | L 4-6 | 70-59 | 3 | 38,504 | Woody Williams | Jon Lieber | Jon Lieber | Woody Williams | Tom Gordon | 627 | 567 | 60 |
| 2001-08-26 | @ CHN | 130 | L 1-6 | 70-60 | 3 | 39,045 | Dustin Hermanson | Juan Cruz | Juan Cruz | Dustin Hermanson | | 628 | 573 | 55 |
| 2001-08-28 | vs SDN | 131 | L 2-5 | 70-61 | 3 | 34,431 | Darryl Kile | Brian Lawrence | Brian Lawrence | Darryl Kile | Trevor Hoffman | 630 | 578 | 52 |
| 2001-08-29 | vs SDN | 132 | W 16-14 | 71-61 | 3 | 31,362 | Bud Smith | Bobby Jones | Gene Stechschulte | Bobby Jones | | 646 | 592 | 54 |
| 2001-08-30 | vs SDN | 133 | W 13-3 | 72-61 | 3 | 28,992 | Matt Morris | Junior Herndon | Matt Morris | Junior Herndon | | 659 | 595 | 64 |
| 2001-08-31 | @ LAN | 134 | W 5-1 | 73-61 | 3 | 45,172 | Woody Williams | Eric Gagne | Woody Williams | Eric Gagne | | 664 | 596 | 68 |
| 2001-09-01 | @ LAN | 135 | L 1-3 | 73-62 | 3 | 37,470 | Dustin Hermanson | Terry Adams | Terry Adams | Dustin Hermanson | Jeff Shaw | 665 | 599 | 66 |
| 2001-09-02 | @ LAN | 136 | L 3-7 | 73-63 | 3 | 54,258 | Darryl Kile | Kevin Brown | Kevin Brown | Darryl Kile | | 668 | 606 | 62 |
| 2001-09-03 | @ SDN | 137 | W 4-0 | 74-63 | 3 | 36,535 | Bud Smith | Bobby Jones | Bud Smith | Bobby Jones | | 672 | 606 | 66 |
| 2001-09-04 | @ SDN | 138 | W 6-1 | 75-63 | 3 | 16,304 | Matt Morris | Junior Herndon | Matt Morris | Junior Herndon | | 678 | 607 | 71 |
| 2001-09-05 | @ SDN | 139 | W 2-0 | 76-63 | 3 | 19,075 | Woody Williams | Kevin Jarvis | Woody Williams | Kevin Jarvis | | 680 | 607 | 73 |
| 2001-09-07 | vs LAN | 140 | L 1-7 | 76-64 | 3 | 33,935 | Dustin Hermanson | Kevin Brown | Kevin Brown | Dustin Hermanson | | 681 | 614 | 67 |
| 2001-09-08 | vs LAN | 141 | W 6-5 | 77-64 | 3 | 41,542 | Alan Benes | James Baldwin | Alan Benes | James Baldwin | Gene Stechschulte | 687 | 619 | 68 |
| 2001-09-09 | vs LAN | 142 | W 8-1 | 78-64 | 2 | 36,337 | Matt Morris | Chan Ho Park | T.J. Mathews | Chan Ho Park | | 695 | 620 | 75 |
| 2001-09-10 | @ MIL | 143 | W 8-0 | 79-64 | 2 | 31,780 | Darryl Kile | Jamey Wright | Darryl Kile | Jamey Wright | Mike Matthews | 703 | 620 | 83 |
| 2001-09-17 | vs MIL | 144 | W 2-1 | 80-64 | 2 | 32,563 | Bud Smith | Ruben Quevedo | Bud Smith | Ruben Quevedo | Steve Kline | 705 | 621 | 84 |
| 2001-09-18 | vs MIL | 145 | W 9-4 | 81-64 | 2 | 41,653 | Dustin Hermanson | Jamey Wright | Dustin Hermanson | Jamey Wright | | 714 | 625 | 89 |
| 2001-09-19 | vs MIL | 146 | W 8-2 | 82-64 | 2 | 29,332 | Matt Morris | Jeff D'Amico | Matt Morris | Jeff D'Amico | | 722 | 627 | 95 |
| 2001-09-20 | @ PIT | 147 | W 9-1 | 83-64 | 2 | 21,678 | Woody Williams | Jimmy Anderson | Woody Williams | Jimmy Anderson | | 731 | 628 | 103 |
| 2001-09-21 | @ PIT | 148 | W 9-5 | 84-64 | 2 | 36,209 | Darryl Kile | Bronson Arroyo | Luther Hackman | Omar Olivares | | 740 | 633 | 107 |
| 2001-09-22 | @ PIT | 149 | W 4-1 | 85-64 | 2 | 37,539 | Bud Smith | Todd Ritchie | Bud Smith | Todd Ritchie | Gene Stechschulte | 744 | 634 | 110 |
| 2001-09-23 | @ PIT | 150 | L 1-2 | 85-65 | 2 | 33,633 | Dustin Hermanson | David Williams | David Williams | Dustin Hermanson | Josias Manzanillo | 745 | 636 | 109 |
| 2001-09-24 | @ HOU | 151 | L 3-9 | 85-66 | 2 | 36,766 | Matt Morris | Dave Mlicki | Dave Mlicki | Matt Morris | | 748 | 645 | 103 |
| 2001-09-25 | @ HOU | 152 | W 3-2 | 86-66 | 2 | 39,715 | Woody Williams | Wade Miller | Woody Williams | Wade Miller | | 751 | 647 | 104 |
| 2001-09-26 | @ HOU | 153 | W 5-1 | 87-66 | 2 | 44,203 | Darryl Kile | Ron Villone | Darryl Kile | Ron Villone | | 756 | 648 | 108 |
| 2001-09-28 | vs PIT | 154 | W 14-3 | 88-66 | 2 | 33,218 | Dustin Hermanson | Todd Ritchie | Dustin Hermanson | Todd Ritchie | | 770 | 651 | 119 |
| 2001-09-29 | vs PIT | 155 | W 2-0 | 89-66 | 2 | 39,782 | Matt Morris | David Williams | Matt Morris | David Williams | Gene Stechschulte | 772 | 651 | 121 |
| 2001-09-30 | vs PIT | 156 | W 7-3 | 90-66 | 2 | 42,442 | Woody Williams | Tony McKnight | Woody Williams | Tony McKnight | | 779 | 654 | 125 |
| 2001-10-02 | @ MIL | 157 | W 5-1 | 91-66 | 2 | 30,890 | Darryl Kile | Ben Sheets | Darryl Kile | Ben Sheets | | 784 | 655 | 129 |
| 2001-10-03 | @ MIL | 158 | L 7-9 | 91-67 | 2 | 33,148 | Bud Smith | Jamey Wright | Jamey Wright | Bud Smith | Chad Fox | 791 | 664 | 127 |
| 2001-10-04 | @ MIL | 159 | W 10-3 | 92-67 | 1 | 28,802 | Matt Morris | Jimmy Haynes | Matt Morris | Jimmy Haynes | | 801 | 667 | 134 |
| 2001-10-05 | vs HOU | 160 | L 1-2 | 92-68 | 2 | 39,323 | Woody Williams | Wade Miller | Michael Jackson | Gene Stechschulte | Billy Wagner | 802 | 669 | 133 |
| 2001-10-06 | vs HOU | 161 | W 10-6 | 93-68 | 1 | 43,251 | Dustin Hermanson | Ron Villone | Mike Timlin | Ron Villone | Steve Kline | 812 | 675 | 137 |
| 2001-10-07 | vs HOU | 162 | L 2-9 | 93-69 | 2 | 47,518 | Darryl Kile | Shane Reynolds | Shane Reynolds | Darryl Kile | | 814 | 684 | 130 |