| 2001-04-02 | vs OAK | 1 | W 5-4 | 1-0 | 1 | 45,911 | Freddy Garcia | Tim Hudson | Arthur Rhodes | Jim Mecir | Kazuhiro Sasaki | 5 | 4 | 1 |
| 2001-04-03 | vs OAK | 2 | L 1-5 | 1-1 | 2 | 27,212 | John Halama | Barry Zito | Barry Zito | John Halama | | 6 | 9 | -3 |
| 2001-04-04 | vs OAK | 3 | W 10-2 | 2-1 | 1 | 31,382 | Aaron Sele | Gil Heredia | Aaron Sele | Gil Heredia | | 16 | 11 | 5 |
| 2001-04-06 | @ TEX | 4 | W 9-7 | 3-1 | 1 | 34,684 | Jamie Moyer | Rick Helling | Arthur Rhodes | Jeff Zimmerman | Kazuhiro Sasaki | 25 | 18 | 7 |
| 2001-04-07 | @ TEX | 5 | W 6-5 | 4-1 | 1 | 41,651 | Brett Tomko | Doug Davis | Ryan Franklin | Doug Davis | Kazuhiro Sasaki | 31 | 23 | 8 |
| 2001-04-08 | @ TEX | 6 | L 4-5 | 4-2 | 1 | 44,306 | Freddy Garcia | Kenny Rogers | Mike Venafro | Jose Paniagua | Tim Crabtree | 35 | 28 | 7 |
| 2001-04-10 | @ OAK | 7 | W 5-1 | 5-2 | 1 | 14,880 | John Halama | Gil Heredia | John Halama | Gil Heredia | Kazuhiro Sasaki | 40 | 29 | 11 |
| 2001-04-11 | @ OAK | 8 | W 3-0 | 6-2 | 1 | 16,652 | Aaron Sele | Mark Mulder | Aaron Sele | Jim Mecir | Kazuhiro Sasaki | 43 | 29 | 14 |
| 2001-04-12 | @ OAK | 9 | W 7-3 | 7-2 | 1 | 15,414 | Jamie Moyer | Tim Hudson | Jamie Moyer | Tim Hudson | | 50 | 32 | 18 |
| 2001-04-13 | @ ANA | 10 | L 3-4 | 7-3 | 1 | 31,087 | Brett Tomko | Scott Schoeneweis | Shigetoshi Hasegawa | Kazuhiro Sasaki | | 53 | 36 | 17 |
| 2001-04-14 | @ ANA | 11 | W 2-1 | 8-3 | 1 | 34,780 | Freddy Garcia | Ismael Valdez | Freddy Garcia | Ismael Valdez | Kazuhiro Sasaki | 55 | 37 | 18 |
| 2001-04-15 | @ ANA | 12 | W 7-5 | 9-3 | 1 | 20,733 | John Halama | Pat Rapp | Jose Paniagua | Shigetoshi Hasegawa | Jeff Nelson | 62 | 42 | 20 |
| 2001-04-16 | vs TEX | 13 | W 9-7 | 10-3 | 1 | 45,657 | Aaron Sele | Ryan Glynn | Ryan Franklin | Ryan Glynn | | 71 | 49 | 22 |
| 2001-04-17 | vs TEX | 14 | W 6-4 | 11-3 | 1 | 34,536 | Jamie Moyer | Rick Helling | Jamie Moyer | Rick Helling | Kazuhiro Sasaki | 77 | 53 | 24 |
| 2001-04-18 | vs TEX | 15 | L 6-8 | 11-4 | 1 | 48,823 | Brett Tomko | Doug Davis | Doug Davis | Brett Tomko | Jeff Zimmerman | 83 | 61 | 22 |
| 2001-04-19 | vs ANA | 16 | W 3-2 | 12-4 | 1 | 25,016 | Freddy Garcia | Ismael Valdez | Freddy Garcia | Ismael Valdez | Kazuhiro Sasaki | 86 | 63 | 23 |
| 2001-04-20 | vs ANA | 17 | W 4-1 | 13-4 | 1 | 38,518 | John Halama | Pat Rapp | John Halama | Pat Rapp | Kazuhiro Sasaki | 90 | 64 | 26 |
| 2001-04-21 | vs ANA | 18 | W 5-2 | 14-4 | 1 | 39,274 | Jamie Moyer | Jarrod Washburn | Jamie Moyer | Jarrod Washburn | Jeff Nelson | 95 | 66 | 29 |
| 2001-04-22 | vs ANA | 19 | W 5-0 | 15-4 | 1 | 44,192 | Aaron Sele | Ramon Ortiz | Aaron Sele | Ramon Ortiz | | 100 | 66 | 34 |
| 2001-04-24 | @ NYA | 20 | W 7-5 | 16-4 | 1 | 29,522 | Freddy Garcia | Roger Clemens | Freddy Garcia | Mike Stanton | Kazuhiro Sasaki | 107 | 71 | 36 |
| 2001-04-25 | @ NYA | 21 | W 7-5 | 17-4 | 1 | 23,684 | John Halama | Andy Pettitte | Norm Charlton | Andy Pettitte | Kazuhiro Sasaki | 114 | 76 | 38 |
| 2001-04-26 | @ NYA | 22 | W 7-3 | 18-4 | 1 | 30,218 | Jamie Moyer | Mike Mussina | Jamie Moyer | Mike Mussina | Arthur Rhodes | 121 | 79 | 42 |
| 2001-04-27 | @ CHA | 23 | W 8-3 | 19-4 | 1 | 16,276 | Aaron Sele | James Baldwin | Aaron Sele | James Baldwin | Kazuhiro Sasaki | 129 | 82 | 47 |
| 2001-04-28 | @ CHA | 24 | W 8-5 | 20-4 | 1 | 25,542 | Paul Abbott | Rocky Biddle | Brett Tomko | Rocky Biddle | Kazuhiro Sasaki | 137 | 87 | 50 |
| 2001-04-29 | @ CHA | 25 | L 1-2 | 20-5 | 1 | 25,442 | Freddy Garcia | Mark Buehrle | Gary Glover | Ryan Franklin | | 138 | 89 | 49 |
| 2001-05-01 | vs BOS | 26 | L 0-2 | 20-6 | 1 | 36,642 | John Halama | Pedro Martinez | Pedro Martinez | John Halama | Rolando Arrojo | 138 | 91 | 47 |
| 2001-05-02 | vs BOS | 27 | W 5-1 | 21-6 | 1 | 40,170 | Aaron Sele | Hideo Nomo | Aaron Sele | Hideo Nomo | | 143 | 92 | 51 |
| 2001-05-03 | vs BOS | 28 | W 10-3 | 22-6 | 1 | 32,513 | Jamie Moyer | Frank Castillo | Jamie Moyer | Frank Castillo | | 153 | 95 | 58 |
| 2001-05-04 | vs TOR | 29 | L 3-8 | 22-7 | 1 | 42,284 | Paul Abbott | Steve Parris | Steve Parris | Paul Abbott | | 156 | 103 | 53 |
| 2001-05-05 | vs TOR | 30 | W 7-5 | 23-7 | 1 | 42,894 | Freddy Garcia | Joey Hamilton | Arthur Rhodes | Pedro Borbon | Kazuhiro Sasaki | 163 | 108 | 55 |
| 2001-05-06 | vs TOR | 31 | L 3-11 | 23-8 | 1 | 45,080 | John Halama | Chris Carpenter | Chris Carpenter | John Halama | | 166 | 119 | 47 |
| 2001-05-08 | @ BOS | 32 | L 4-12 | 23-9 | 1 | 32,941 | Jamie Moyer | Hideo Nomo | Hideo Nomo | Jamie Moyer | | 170 | 131 | 39 |
| 2001-05-09 | @ BOS | 33 | W 10-5 | 24-9 | 1 | 31,616 | Aaron Sele | Frank Castillo | Jeff Nelson | Rolando Arrojo | Kazuhiro Sasaki | 180 | 136 | 44 |
| 2001-05-10 | @ BOS | 34 | W 5-2 | 25-9 | 1 | 31,428 | John Halama | Tomo Ohka | John Halama | Tomo Ohka | Kazuhiro Sasaki | 185 | 138 | 47 |
| 2001-05-11 | @ TOR | 35 | W 7-2 | 26-9 | 1 | 20,279 | Paul Abbott | Joey Hamilton | Paul Abbott | Joey Hamilton | | 192 | 140 | 52 |
| 2001-05-12 | @ TOR | 36 | W 11-7 | 27-9 | 1 | 24,908 | Freddy Garcia | Chris Carpenter | Brett Tomko | Kelvim Escobar | | 203 | 147 | 56 |
| 2001-05-13 | @ TOR | 37 | W 7-5 | 28-9 | 1 | 20,624 | Jamie Moyer | Esteban Loaiza | Jamie Moyer | Esteban Loaiza | Kazuhiro Sasaki | 210 | 152 | 58 |
| 2001-05-15 | vs CHA | 38 | W 4-3 | 29-9 | 1 | 31,096 | Aaron Sele | Mark Buehrle | Jeff Nelson | Bob Howry | Jose Paniagua | 214 | 155 | 59 |
| 2001-05-16 | vs CHA | 39 | W 7-2 | 30-9 | 1 | 33,748 | Paul Abbott | Rocky Biddle | Paul Abbott | Rocky Biddle | Jose Paniagua | 221 | 157 | 64 |
| 2001-05-17 | vs CHA | 40 | W 5-1 | 31-9 | 1 | 43,510 | Freddy Garcia | David Wells | Freddy Garcia | David Wells | Jeff Nelson | 226 | 158 | 68 |
| 2001-05-18 | vs NYA | 41 | L 10-14 | 31-10 | 1 | 45,794 | John Halama | Ted Lilly | Ramiro Mendoza | John Halama | | 236 | 172 | 64 |
| 2001-05-19 | vs NYA | 42 | L 1-2 | 31-11 | 1 | 45,880 | Jamie Moyer | Orlando Hernandez | Mike Stanton | Kazuhiro Sasaki | Mariano Rivera | 237 | 174 | 63 |
| 2001-05-20 | vs NYA | 43 | W 6-2 | 32-11 | 1 | 45,953 | Aaron Sele | Roger Clemens | Aaron Sele | Roger Clemens | | 243 | 176 | 67 |
| 2001-05-22 | @ MIN | 44 | L 11-12 | 32-12 | 1 | 29,005 | Paul Abbott | Brad Radke | Bob Wells | Paul Abbott | | 254 | 188 | 66 |
| 2001-05-23 | @ MIN | 45 | W 5-4 | 33-12 | 1 | 26,605 | Freddy Garcia | Eric Milton | Arthur Rhodes | Hector Carrasco | Kazuhiro Sasaki | 259 | 192 | 67 |
| 2001-05-25 | @ KCA | 46 | W 9-6 | 34-12 | 1 | 17,555 | John Halama | Dan Reichert | Ryan Franklin | Jason Grimsley | Kazuhiro Sasaki | 268 | 198 | 70 |
| 2001-05-26 | @ KCA | 47 | W 7-2 | 35-12 | 1 | 21,368 | Aaron Sele | Brian Meadows | Aaron Sele | Brian Meadows | | 275 | 200 | 75 |
| 2001-05-27 | @ KCA | 48 | W 5-4 | 36-12 | 1 | 19,524 | Jamie Moyer | Jeff Suppan | Norm Charlton | Jose Santiago | | 280 | 204 | 76 |
| 2001-05-28 | @ KCA | 49 | W 13-3 | 37-12 | 1 | 20,142 | Paul Abbott | Chad Durbin | Paul Abbott | Chad Durbin | | 293 | 207 | 86 |
| 2001-05-29 | vs BAL | 50 | W 3-2 | 38-12 | 1 | 30,413 | Freddy Garcia | Willis Roberts | Freddy Garcia | Willis Roberts | Kazuhiro Sasaki | 296 | 209 | 87 |
| 2001-05-30 | vs BAL | 51 | W 12-5 | 39-12 | 1 | 34,757 | John Halama | Jason Johnson | John Halama | Jason Johnson | | 308 | 214 | 94 |
| 2001-05-31 | vs BAL | 52 | W 2-1 | 40-12 | 1 | 37,612 | Aaron Sele | Jose Mercedes | Aaron Sele | Jose Mercedes | Kazuhiro Sasaki | 310 | 215 | 95 |
| 2001-06-01 | vs TBA | 53 | W 8-4 | 41-12 | 1 | 41,094 | Jamie Moyer | Bryan Rekar | Jamie Moyer | Bryan Rekar | Jeff Nelson | 318 | 219 | 99 |
| 2001-06-02 | vs TBA | 54 | W 7-4 | 42-12 | 1 | 45,473 | Paul Abbott | Ryan Rupe | Paul Abbott | Ryan Rupe | Kazuhiro Sasaki | 325 | 223 | 102 |
| 2001-06-03 | vs TBA | 55 | W 8-4 | 43-12 | 1 | 45,390 | Freddy Garcia | Tanyon Sturtze | Freddy Garcia | Tanyon Sturtze | Kazuhiro Sasaki | 333 | 227 | 106 |
| 2001-06-04 | vs TEX | 56 | W 11-6 | 44-12 | 1 | 45,812 | John Halama | Pat Mahomes | Ryan Franklin | Mike Venafro | | 344 | 233 | 111 |
| 2001-06-05 | vs TEX | 57 | W 5-4 | 45-12 | 1 | 44,853 | Aaron Sele | Doug Davis | Jose Paniagua | J.D. Smart | Kazuhiro Sasaki | 349 | 237 | 112 |
| 2001-06-06 | vs TEX | 58 | W 7-3 | 46-12 | 1 | 45,754 | Jamie Moyer | Darren Oliver | Jamie Moyer | Darren Oliver | | 356 | 240 | 116 |
| 2001-06-08 | vs SDN | 59 | W 7-1 | 47-12 | 1 | 45,293 | Paul Abbott | Kevin Jarvis | Paul Abbott | Kevin Jarvis | | 363 | 241 | 122 |
| 2001-06-09 | vs SDN | 60 | L 3-6 | 47-13 | 1 | 45,322 | Freddy Garcia | Bobby Jones | Bobby Jones | Freddy Garcia | Trevor Hoffman | 366 | 247 | 119 |
| 2001-06-10 | vs SDN | 61 | W 8-1 | 48-13 | 1 | 45,418 | John Halama | Carlton Loewer | John Halama | Carlton Loewer | | 374 | 248 | 126 |
| 2001-06-12 | @ COL | 62 | W 10-9 | 49-13 | 1 | 41,263 | Aaron Sele | Brian Bohanon | Brian Fuentes | Juan Acevedo | Kazuhiro Sasaki | 384 | 257 | 127 |
| 2001-06-14 | @ COL | 63 | L 2-8 | 50-14 | 1 | 45,261 | Jamie Moyer | Shawn Chacon | Shawn Chacon | Jamie Moyer | | 386 | 265 | 121 |
| 2001-06-14 | @ COL | 64 | W 5-1 | 50-14 | 1 | 37,048 | Paul Abbott | Pedro Astacio | Paul Abbott | Pedro Astacio | | 391 | 266 | 125 |
| 2001-06-15 | @ SDN | 65 | W 8-4 | 51-14 | 1 | 60,918 | Freddy Garcia | Bobby Jones | Freddy Garcia | Bobby Jones | | 399 | 270 | 129 |
| 2001-06-16 | @ SDN | 66 | W 9-2 | 52-14 | 1 | 61,065 | John Halama | Carlton Loewer | John Halama | Carlton Loewer | | 408 | 272 | 136 |
| 2001-06-17 | @ SDN | 67 | L 9-11 | 52-15 | 1 | 36,027 | Aaron Sele | Woody Williams | Tom Davey | Jeff Nelson | Trevor Hoffman | 417 | 283 | 134 |
| 2001-06-18 | @ OAK | 68 | L 3-4 | 52-16 | 1 | 16,368 | Jamie Moyer | Barry Zito | Barry Zito | Norm Charlton | Jason Isringhausen | 420 | 287 | 133 |
| 2001-06-19 | @ OAK | 69 | W 8-7 | 53-16 | 1 | 17,542 | Paul Abbott | Gil Heredia | Arthur Rhodes | Jason Isringhausen | Kazuhiro Sasaki | 428 | 294 | 134 |
| 2001-06-20 | @ OAK | 70 | L 4-6 | 53-17 | 1 | 40,639 | Freddy Garcia | Mark Mulder | Mark Guthrie | Kazuhiro Sasaki | | 432 | 300 | 132 |
| 2001-06-21 | @ OAK | 71 | W 12-10 | 54-17 | 1 | 23,642 | John Halama | Cory Lidle | Jose Paniagua | Jeff Tam | Arthur Rhodes | 444 | 310 | 134 |
| 2001-06-22 | vs ANA | 72 | L 1-8 | 54-18 | 1 | 45,461 | Aaron Sele | Jarrod Washburn | Jarrod Washburn | Aaron Sele | | 445 | 318 | 127 |
| 2001-06-23 | vs ANA | 73 | L 1-2 | 54-19 | 1 | 45,430 | Jamie Moyer | Pat Rapp | Pat Rapp | Jamie Moyer | Troy Percival | 446 | 320 | 126 |
| 2001-06-24 | vs ANA | 74 | W 7-3 | 55-19 | 1 | 45,722 | Paul Abbott | Scott Schoeneweis | Paul Abbott | Scott Schoeneweis | Kazuhiro Sasaki | 453 | 323 | 130 |
| 2001-06-26 | vs OAK | 75 | W 7-3 | 56-19 | 1 | 45,337 | Freddy Garcia | Mark Mulder | Freddy Garcia | Mark Mulder | | 460 | 326 | 134 |
| 2001-06-27 | vs OAK | 76 | L 3-6 | 56-20 | 1 | 45,104 | John Halama | Tim Hudson | Tim Hudson | John Halama | Jason Isringhausen | 463 | 332 | 131 |
| 2001-06-28 | vs OAK | 77 | L 3-6 | 56-21 | 1 | 45,399 | Aaron Sele | Barry Zito | Mark Guthrie | Brian Fuentes | Jason Isringhausen | 466 | 338 | 128 |
| 2001-06-29 | @ ANA | 78 | W 9-5 | 57-21 | 1 | 40,822 | Jamie Moyer | Scott Schoeneweis | Jamie Moyer | Scott Schoeneweis | | 475 | 343 | 132 |
| 2001-06-30 | @ ANA | 79 | W 5-3 | 58-21 | 1 | 27,784 | Denny Stark | Ramon Ortiz | Denny Stark | Ramon Ortiz | Kazuhiro Sasaki | 480 | 346 | 134 |
| 2001-07-01 | @ ANA | 80 | W 5-0 | 59-21 | 1 | 28,887 | Freddy Garcia | Matt Wise | Freddy Garcia | Matt Wise | | 485 | 346 | 139 |
| 2001-07-02 | @ TEX | 81 | W 9-7 | 60-21 | 1 | 28,487 | Paul Abbott | Doug Davis | Jeff Nelson | Mark Petkovsek | Kazuhiro Sasaki | 494 | 353 | 141 |
| 2001-07-03 | @ TEX | 82 | W 8-4 | 61-21 | 1 | 41,849 | Aaron Sele | Darren Oliver | Aaron Sele | Darren Oliver | | 502 | 357 | 145 |
| 2001-07-04 | @ TEX | 83 | L 3-6 | 61-22 | 1 | 49,103 | Jamie Moyer | Rob Bell | Rob Bell | Jamie Moyer | Mike Venafro | 505 | 363 | 142 |
| 2001-07-05 | @ TEX | 84 | L 2-14 | 61-23 | 1 | 29,797 | Denny Stark | Kenny Rogers | Kenny Rogers | Denny Stark | | 507 | 377 | 130 |
| 2001-07-06 | @ LAN | 85 | W 13-0 | 62-23 | 1 | 53,072 | Freddy Garcia | Kevin Brown | Freddy Garcia | Kevin Brown | | 520 | 377 | 143 |
| 2001-07-07 | @ LAN | 86 | L 1-2 | 62-24 | 1 | 40,937 | Paul Abbott | Terry Adams | Matt Herges | Jose Paniagua | | 521 | 379 | 142 |
| 2001-07-08 | @ LAN | 87 | W 9-2 | 63-24 | 1 | 40,511 | Aaron Sele | Jeff Williams | Aaron Sele | Jeff Williams | | 530 | 381 | 149 |
| 2001-07-12 | vs SFN | 88 | W 4-3 | 64-24 | 1 | 45,696 | Paul Abbott | Kirk Rueter | Arthur Rhodes | Brian Boehringer | | 534 | 384 | 150 |
| 2001-07-13 | vs SFN | 89 | L 3-5 | 64-25 | 1 | 45,909 | Jamie Moyer | Russ Ortiz | Russ Ortiz | Jamie Moyer | Robb Nen | 537 | 389 | 148 |
| 2001-07-14 | vs SFN | 90 | W 3-2 | 65-25 | 1 | 45,809 | Freddy Garcia | Shawn Estes | Freddy Garcia | Shawn Estes | Kazuhiro Sasaki | 540 | 391 | 149 |
| 2001-07-15 | vs ARI | 91 | W 8-0 | 66-25 | 1 | 45,855 | Aaron Sele | Robert Ellis | Aaron Sele | Robert Ellis | | 548 | 391 | 157 |
| 2001-07-16 | vs ARI | 92 | L 3-5 | 66-26 | 1 | 45,770 | John Halama | Miguel Batista | Miguel Batista | John Halama | Byung-Hyun Kim | 551 | 396 | 155 |
| 2001-07-17 | vs ARI | 93 | W 6-1 | 67-26 | 1 | 45,894 | Paul Abbott | Brian Anderson | Paul Abbott | Brian Anderson | | 557 | 397 | 160 |
| 2001-07-18 | @ KCA | 94 | W 2-0 | 68-26 | 1 | 15,818 | Jamie Moyer | Chad Durbin | Jeff Nelson | Roberto Hernandez | Kazuhiro Sasaki | 559 | 397 | 162 |
| 2001-07-19 | @ KCA | 95 | L 3-6 | 68-27 | 1 | 21,566 | Freddy Garcia | Kris Wilson | Kris Wilson | Freddy Garcia | | 562 | 403 | 159 |
| 2001-07-20 | @ MIN | 96 | W 4-0 | 69-27 | 1 | 36,863 | Aaron Sele | Joe Mays | Aaron Sele | Joe Mays | | 566 | 403 | 163 |
| 2001-07-21 | @ MIN | 97 | W 6-3 | 70-27 | 1 | 33,501 | Joel Pineiro | Adam Johnson | John Halama | Adam Johnson | Kazuhiro Sasaki | 572 | 406 | 166 |
| 2001-07-22 | @ MIN | 98 | W 6-3 | 71-27 | 1 | 44,665 | Paul Abbott | Kyle Lohse | Paul Abbott | Kyle Lohse | | 578 | 409 | 169 |
| 2001-07-23 | @ MIN | 99 | W 3-2 | 72-27 | 1 | 31,220 | Jamie Moyer | Brad Radke | Jamie Moyer | Brad Radke | Kazuhiro Sasaki | 581 | 411 | 170 |
| 2001-07-24 | vs KCA | 100 | L 1-6 | 72-28 | 1 | 45,119 | Freddy Garcia | Kris Wilson | Kris Wilson | Freddy Garcia | | 582 | 417 | 165 |
| 2001-07-25 | vs KCA | 101 | L 1-5 | 72-29 | 1 | 45,265 | Aaron Sele | Paul Byrd | Paul Byrd | Aaron Sele | | 583 | 422 | 161 |
| 2001-07-26 | vs KCA | 102 | W 4-0 | 73-29 | 1 | 44,519 | Joel Pineiro | Chris George | Joel Pineiro | Chris George | | 587 | 422 | 165 |
| 2001-07-27 | vs MIN | 103 | W 11-4 | 74-29 | 1 | 45,808 | Paul Abbott | Kyle Lohse | Paul Abbott | Kyle Lohse | | 598 | 426 | 172 |
| 2001-07-28 | vs MIN | 104 | W 5-1 | 75-29 | 1 | 45,681 | Jamie Moyer | Brad Radke | Jamie Moyer | Brad Radke | | 603 | 427 | 176 |
| 2001-07-29 | vs MIN | 105 | W 10-2 | 76-29 | 1 | 45,780 | Freddy Garcia | Eric Milton | Freddy Garcia | Eric Milton | | 613 | 429 | 184 |
| 2001-07-31 | @ DET | 106 | L 2-4 | 76-30 | 1 | 30,022 | Aaron Sele | Jose Lima | Jose Lima | Aaron Sele | Matt Anderson | 615 | 433 | 182 |
| 2001-08-01 | @ DET | 107 | W 7-1 | 77-30 | 1 | 23,847 | Paul Abbott | Chris Holt | Paul Abbott | Chris Holt | | 622 | 434 | 188 |
| 2001-08-02 | @ DET | 108 | W 2-1 | 78-30 | 1 | 27,097 | Joel Pineiro | Adam Pettyjohn | Joel Pineiro | Adam Pettyjohn | Kazuhiro Sasaki | 624 | 435 | 189 |
| 2001-08-03 | @ CLE | 109 | W 2-1 | 79-30 | 1 | 42,580 | Jamie Moyer | Bartolo Colon | Jamie Moyer | Bartolo Colon | Kazuhiro Sasaki | 626 | 436 | 190 |
| 2001-08-04 | @ CLE | 110 | W 8-5 | 80-30 | 1 | 42,440 | Freddy Garcia | Steve Woodard | Freddy Garcia | Danys Baez | Arthur Rhodes | 634 | 441 | 193 |
| 2001-08-05 | @ CLE | 111 | L 14-15 | 80-31 | 1 | 42,494 | Aaron Sele | Dave Burba | John Rocker | Jose Paniagua | | 648 | 456 | 192 |
| 2001-08-06 | @ CLE | 112 | W 8-6 | 81-31 | 1 | 42,058 | Paul Abbott | Charles Nagy | Paul Abbott | Charles Nagy | Jose Paniagua | 656 | 462 | 194 |
| 2001-08-07 | vs TOR | 113 | W 5-4 | 82-31 | 1 | 45,636 | Joel Pineiro | Roy Halladay | John Halama | Matt DeWitt | | 661 | 466 | 195 |
| 2001-08-08 | vs TOR | 114 | W 12-4 | 83-31 | 1 | 45,450 | Jamie Moyer | Chris Carpenter | Jamie Moyer | Chris Carpenter | | 673 | 470 | 203 |
| 2001-08-09 | vs TOR | 115 | L 5-6 | 83-32 | 1 | 45,670 | Freddy Garcia | Kelvim Escobar | Paul Quantrill | Freddy Garcia | Billy Koch | 678 | 476 | 202 |
| 2001-08-10 | vs CHA | 116 | L 6-8 | 83-33 | 1 | 45,665 | Aaron Sele | Jon Garland | Rocky Biddle | Kazuhiro Sasaki | Keith Foulke | 684 | 484 | 200 |
| 2001-08-11 | vs CHA | 117 | W 4-3 | 84-33 | 1 | 45,898 | Paul Abbott | Dan Wright | Ryan Franklin | Keith Foulke | | 688 | 487 | 201 |
| 2001-08-12 | vs CHA | 118 | W 2-1 | 85-33 | 1 | 45,765 | Joel Pineiro | Gary Glover | Arthur Rhodes | Kip Wells | Kazuhiro Sasaki | 690 | 488 | 202 |
| 2001-08-14 | @ BOS | 119 | W 6-3 | 86-33 | 1 | 33,790 | Jamie Moyer | Hideo Nomo | Jose Paniagua | Rod Beck | Kazuhiro Sasaki | 696 | 491 | 205 |
| 2001-08-15 | @ BOS | 120 | W 6-2 | 87-33 | 1 | 33,186 | Freddy Garcia | Frank Castillo | Freddy Garcia | Frank Castillo | | 702 | 493 | 209 |
| 2001-08-16 | @ BOS | 121 | L 4-6 | 87-34 | 1 | 33,548 | Aaron Sele | David Cone | Rich Garces | Aaron Sele | Ugueth Urbina | 706 | 499 | 207 |
| 2001-08-17 | @ NYA | 122 | L 0-4 | 87-35 | 1 | 54,616 | Paul Abbott | Mike Mussina | Mike Mussina | Paul Abbott | Ramiro Mendoza | 706 | 503 | 203 |
| 2001-08-18 | @ NYA | 123 | W 7-6 | 88-35 | 1 | 55,294 | Joel Pineiro | Ted Lilly | Arthur Rhodes | Ted Lilly | Kazuhiro Sasaki | 713 | 509 | 204 |
| 2001-08-19 | @ NYA | 124 | W 10-2 | 89-35 | 1 | 54,339 | Jamie Moyer | Andy Pettitte | Jamie Moyer | Andy Pettitte | | 723 | 511 | 212 |
| 2001-08-20 | vs DET | 125 | L 1-4 | 89-36 | 1 | 45,972 | Freddy Garcia | Steve Sparks | Steve Sparks | Freddy Garcia | | 724 | 515 | 209 |
| 2001-08-21 | vs DET | 126 | W 4-1 | 90-36 | 1 | 45,036 | Aaron Sele | Jeff Weaver | Aaron Sele | Jeff Weaver | Kazuhiro Sasaki | 728 | 516 | 212 |
| 2001-08-22 | vs DET | 127 | W 16-1 | 91-36 | 1 | 45,814 | Paul Abbott | Jose Lima | Paul Abbott | Jose Lima | | 744 | 517 | 227 |
| 2001-08-23 | vs DET | 128 | W 5-1 | 92-36 | 1 | 45,063 | Joel Pineiro | Mark Redman | Joel Pineiro | Mark Redman | | 749 | 518 | 231 |
| 2001-08-24 | vs CLE | 129 | W 4-1 | 93-36 | 1 | 45,767 | Jamie Moyer | Bartolo Colon | Jamie Moyer | Bartolo Colon | Norm Charlton | 753 | 519 | 234 |
| 2001-08-25 | vs CLE | 130 | W 3-2 | 94-36 | 1 | 45,818 | Freddy Garcia | Chuck Finley | John Halama | John Rocker | | 756 | 521 | 235 |
| 2001-08-26 | vs CLE | 131 | L 3-4 | 94-37 | 1 | 45,782 | Aaron Sele | Steve Woodard | David Riske | Jeff Nelson | Bob Wickman | 759 | 525 | 234 |
| 2001-08-28 | @ TBA | 132 | L 0-6 | 94-38 | 1 | 11,687 | Joel Pineiro | Paul Wilson | Paul Wilson | Joel Pineiro | | 759 | 531 | 228 |
| 2001-08-29 | @ TBA | 133 | W 5-2 | 95-38 | 1 | 12,792 | Jamie Moyer | Tanyon Sturtze | Jamie Moyer | Tanyon Sturtze | | 764 | 533 | 231 |
| 2001-08-30 | @ TBA | 134 | W 4-0 | 96-38 | 1 | 12,260 | Freddy Garcia | Ryan Rupe | Freddy Garcia | Ryan Rupe | | 768 | 533 | 235 |
| 2001-08-31 | @ BAL | 135 | L 0-3 | 96-39 | 1 | 37,084 | Aaron Sele | Calvin Maduro | Calvin Maduro | Aaron Sele | | 768 | 536 | 232 |
| 2001-09-01 | @ BAL | 136 | W 6-4 | 97-39 | 1 | 45,668 | Paul Abbott | Jose Mercedes | Paul Abbott | Jose Mercedes | Kazuhiro Sasaki | 774 | 540 | 234 |
| 2001-09-02 | @ BAL | 137 | W 1-0 | 98-39 | 1 | 45,359 | Joel Pineiro | Rick Bauer | Joel Pineiro | Rick Bauer | Kazuhiro Sasaki | 775 | 540 | 235 |
| 2001-09-03 | vs TBA | 138 | W 3-2 | 99-39 | 1 | 45,728 | Jamie Moyer | Paul Wilson | Norm Charlton | Esteban Yan | | 778 | 542 | 236 |
| 2001-09-04 | vs TBA | 139 | L 3-8 | 99-40 | 1 | 44,859 | Freddy Garcia | Tanyon Sturtze | Victor Zambrano | Norm Charlton | | 781 | 550 | 231 |
| 2001-09-05 | vs TBA | 140 | W 12-6 | 100-40 | 1 | 44,720 | Aaron Sele | Ryan Rupe | John Halama | Travis Phelps | | 793 | 556 | 237 |
| 2001-09-07 | vs BAL | 141 | W 10-1 | 101-40 | 1 | 45,797 | Paul Abbott | Jose Mercedes | Paul Abbott | Jose Mercedes | | 803 | 557 | 246 |
| 2001-09-08 | vs BAL | 142 | W 6-1 | 102-40 | 1 | 45,894 | Joel Pineiro | Rick Bauer | Joel Pineiro | Rick Bauer | | 809 | 558 | 251 |
| 2001-09-09 | vs BAL | 143 | W 6-0 | 103-40 | 1 | 45,344 | Jamie Moyer | Josh Towers | Jamie Moyer | Josh Towers | | 815 | 558 | 257 |
| 2001-09-10 | @ ANA | 144 | W 5-1 | 104-40 | 1 | 20,311 | Freddy Garcia | Ismael Valdez | Freddy Garcia | Ismael Valdez | | 820 | 559 | 261 |
| 2001-09-18 | vs ANA | 145 | W 4-0 | 105-40 | 1 | 45,294 | Freddy Garcia | Ramon Ortiz | Freddy Garcia | Ramon Ortiz | | 824 | 559 | 265 |
| 2001-09-19 | vs ANA | 146 | W 5-0 | 106-40 | 1 | 45,459 | Jamie Moyer | Scott Schoeneweis | Jamie Moyer | Scott Schoeneweis | | 829 | 559 | 270 |
| 2001-09-20 | vs ANA | 147 | L 3-6 | 106-41 | 1 | 44,768 | Aaron Sele | Jarrod Washburn | Shigetoshi Hasegawa | John Halama | Troy Percival | 832 | 565 | 267 |
| 2001-09-21 | @ OAK | 148 | L 1-5 | 106-42 | 1 | 30,387 | Paul Abbott | Cory Lidle | Cory Lidle | Paul Abbott | Jason Isringhausen | 833 | 570 | 263 |
| 2001-09-22 | @ OAK | 149 | L 2-11 | 106-43 | 1 | 45,734 | Joel Pineiro | Erik Hiljus | Erik Hiljus | Joel Pineiro | | 835 | 581 | 254 |
| 2001-09-23 | @ OAK | 150 | L 4-7 | 106-44 | 1 | 38,628 | Freddy Garcia | Mark Mulder | Mark Mulder | Freddy Garcia | Jason Isringhausen | 839 | 588 | 251 |
| 2001-09-24 | @ TEX | 151 | W 9-3 | 107-44 | 1 | 22,765 | Jamie Moyer | Doug Davis | Jamie Moyer | Doug Davis | | 848 | 591 | 257 |
| 2001-09-25 | @ TEX | 152 | W 13-2 | 108-44 | 1 | 27,781 | Aaron Sele | Justin Duchscherer | Aaron Sele | Justin Duchscherer | | 861 | 593 | 268 |
| 2001-09-26 | @ TEX | 153 | W 7-5 | 109-44 | 1 | 24,712 | Paul Abbott | Rob Bell | Paul Abbott | Rob Bell | Kazuhiro Sasaki | 868 | 598 | 270 |
| 2001-09-28 | vs OAK | 154 | W 5-3 | 110-44 | 1 | 45,695 | Freddy Garcia | Mark Mulder | Freddy Garcia | Mark Mulder | Kazuhiro Sasaki | 873 | 601 | 272 |
| 2001-09-29 | vs OAK | 155 | L 4-8 | 110-45 | 1 | 45,104 | Jamie Moyer | Erik Hiljus | Erik Hiljus | Jamie Moyer | | 877 | 609 | 268 |
| 2001-09-30 | vs OAK | 156 | W 6-3 | 111-45 | 1 | 45,674 | Aaron Sele | Tim Hudson | Aaron Sele | Tim Hudson | | 883 | 612 | 271 |
| 2001-10-02 | @ ANA | 157 | W 14-5 | 112-45 | 1 | 18,600 | Paul Abbott | Jarrod Washburn | Paul Abbott | Jarrod Washburn | | 897 | 617 | 280 |
| 2001-10-03 | @ ANA | 158 | W 4-3 | 113-45 | 1 | 18,503 | Freddy Garcia | Matt Wise | Norm Charlton | Al Levine | Kazuhiro Sasaki | 901 | 620 | 281 |
| 2001-10-04 | vs TEX | 159 | W 16-1 | 114-45 | 1 | 45,302 | Brett Tomko | Aaron Myette | Brett Tomko | Aaron Myette | | 917 | 621 | 296 |
| 2001-10-05 | vs TEX | 160 | W 6-2 | 115-45 | 1 | 45,333 | Jamie Moyer | Rick Helling | Jamie Moyer | Rick Helling | | 923 | 623 | 300 |
| 2001-10-06 | vs TEX | 161 | W 1-0 | 116-45 | 1 | 45,607 | Denny Stark | Doug Davis | Joel Pineiro | Doug Davis | Kazuhiro Sasaki | 924 | 623 | 301 |
| 2001-10-07 | vs TEX | 162 | L 3-4 | 116-46 | 1 | 45,578 | Aaron Sele | Darren Oliver | Pat Mahomes | Jeff Nelson | Jeff Zimmerman | 927 | 627 | 300 |