| 2001-04-02 | vs SDN | 1 | W 3-2 | 1-0 | 3 | 40,930 | Livan Hernandez | Woody Williams | Livan Hernandez | Woody Williams | Robb Nen | 3 | 2 | 1 |
| 2001-04-04 | vs SDN | 2 | W 8-7 | 2-0 | 3 | 40,930 | Kirk Rueter | Kevin Jarvis | Robb Nen | Jay Witasick | | 11 | 9 | 2 |
| 2001-04-05 | vs SDN | 3 | W 8-2 | 3-0 | 2 | 40,930 | Russ Ortiz | Bobby Jones | Russ Ortiz | Bobby Jones | | 19 | 11 | 8 |
| 2001-04-06 | @ LAN | 4 | L 1-10 | 3-1 | 2 | 36,508 | Shawn Estes | Luke Prokopec | Luke Prokopec | Shawn Estes | | 20 | 21 | -1 |
| 2001-04-07 | @ LAN | 5 | L 4-10 | 3-2 | 3 | 38,417 | Livan Hernandez | Chan Ho Park | Chan Ho Park | Livan Hernandez | | 24 | 31 | -7 |
| 2001-04-08 | @ LAN | 6 | W 8-3 | 4-2 | 1 | 37,549 | Kirk Rueter | Eric Gagne | Kirk Rueter | Eric Gagne | | 32 | 34 | -2 |
| 2001-04-10 | @ SDN | 7 | W 11-6 | 5-2 | 1 | 61,277 | Russ Ortiz | Kevin Jarvis | Russ Ortiz | Kevin Jarvis | | 43 | 40 | 3 |
| 2001-04-11 | @ SDN | 8 | W 2-1 | 6-2 | 1 | 50,149 | Shawn Estes | Bobby Jones | Aaron Fultz | Trevor Hoffman | Robb Nen | 45 | 41 | 4 |
| 2001-04-12 | @ SDN | 9 | L 3-8 | 6-3 | 1 | 25,730 | Livan Hernandez | Adam Eaton | Adam Eaton | Livan Hernandez | | 48 | 49 | -1 |
| 2001-04-13 | @ MIL | 10 | W 7-3 | 7-3 | 1 | 34,998 | Kirk Rueter | Jamey Wright | Kirk Rueter | Jamey Wright | | 55 | 52 | 3 |
| 2001-04-14 | @ MIL | 11 | L 6-11 | 7-4 | 1 | 42,080 | Mark Gardner | Jimmy Haynes | Mike DeJean | Mark Gardner | | 61 | 63 | -2 |
| 2001-04-15 | @ MIL | 12 | L 4-7 | 7-5 | 1 | 25,981 | Russ Ortiz | Paul Rigdon | Paul Rigdon | Russ Ortiz | Curt Leskanic | 65 | 70 | -5 |
| 2001-04-17 | vs LAN | 13 | W 3-2 | 8-5 | 1 | 41,059 | Shawn Estes | Darren Dreifort | Felix Rodriguez | Terry Adams | Robb Nen | 68 | 72 | -4 |
| 2001-04-18 | vs LAN | 14 | W 5-4 | 9-5 | 1 | 41,059 | Livan Hernandez | Chan Ho Park | Aaron Fultz | Chan Ho Park | Robb Nen | 73 | 76 | -3 |
| 2001-04-19 | vs LAN | 15 | L 1-10 | 9-6 | 2 | 41,059 | Kirk Rueter | Eric Gagne | Eric Gagne | Kirk Rueter | | 74 | 86 | -12 |
| 2001-04-20 | vs MIL | 16 | W 3-1 | 10-6 | 1 | 41,059 | Russ Ortiz | Jimmy Haynes | Russ Ortiz | Jimmy Haynes | Robb Nen | 77 | 87 | -10 |
| 2001-04-21 | vs MIL | 17 | L 3-6 | 10-7 | 1 | 41,059 | Mark Gardner | Paul Rigdon | Paul Rigdon | Mark Gardner | David Weathers | 80 | 93 | -13 |
| 2001-04-22 | vs MIL | 18 | W 6-4 | 11-7 | 1 | 41,059 | Shawn Estes | Jeff D'Amico | Shawn Estes | Jeff D'Amico | Robb Nen | 86 | 97 | -11 |
| 2001-04-24 | vs CIN | 19 | L 5-9 | 11-8 | 2 | 40,723 | Livan Hernandez | Jim Brower | Jim Brower | Livan Hernandez | | 91 | 106 | -15 |
| 2001-04-25 | vs CIN | 20 | L 5-7 | 11-9 | 2 | 40,763 | Kirk Rueter | Osvaldo Fernandez | Osvaldo Fernandez | Kirk Rueter | Danny Graves | 96 | 113 | -17 |
| 2001-04-26 | vs CIN | 21 | L 5-7 | 11-10 | 4 | 41,059 | Russ Ortiz | Pete Harnisch | Dennys Reyes | Alan Embree | Danny Graves | 101 | 120 | -19 |
| 2001-04-27 | vs CHN | 22 | L 3-7 | 11-11 | 4 | 41,059 | Mark Gardner | Kerry Wood | Kerry Wood | Mark Gardner | | 104 | 127 | -23 |
| 2001-04-28 | vs CHN | 23 | W 5-0 | 12-11 | 3 | 41,059 | Shawn Estes | Julian Tavarez | Shawn Estes | Julian Tavarez | | 109 | 127 | -18 |
| 2001-04-29 | vs CHN | 24 | L 2-11 | 12-12 | 4 | 41,059 | Livan Hernandez | Manny Aybar | Manny Aybar | Livan Hernandez | | 111 | 138 | -27 |
| 2001-05-01 | @ PIT | 25 | W 11-6 | 13-12 | 4 | 22,926 | Kirk Rueter | Ramon Martinez | Kirk Rueter | Ramon Martinez | | 122 | 144 | -22 |
| 2001-05-02 | @ PIT | 26 | W 7-6 | 14-12 | 3 | 22,880 | Russ Ortiz | Todd Ritchie | Russ Ortiz | Jose Silva | Robb Nen | 129 | 150 | -21 |
| 2001-05-03 | @ PIT | 27 | L 3-4 | 14-13 | 4 | 23,048 | Shawn Estes | Jimmy Anderson | Jose Silva | Shawn Estes | Mike Williams | 132 | 154 | -22 |
| 2001-05-04 | @ PHI | 28 | W 4-2 | 15-13 | 3 | 20,713 | Livan Hernandez | Bruce Chen | Livan Hernandez | Bruce Chen | Robb Nen | 136 | 156 | -20 |
| 2001-05-05 | @ PHI | 29 | L 2-4 | 15-14 | 3 | 17,887 | Mark Gardner | Randy Wolf | Randy Wolf | Aaron Fultz | Jose Mesa | 138 | 160 | -22 |
| 2001-05-06 | @ PHI | 30 | L 8-10 | 15-15 | 4 | 25,206 | Kirk Rueter | Omar Daal | Omar Daal | Kirk Rueter | Jose Mesa | 146 | 170 | -24 |
| 2001-05-07 | vs MON | 31 | W 6-2 | 16-15 | 2 | 38,249 | Russ Ortiz | Tony Armas | Russ Ortiz | Tony Armas | Aaron Fultz | 152 | 172 | -20 |
| 2001-05-08 | vs MON | 32 | W 9-1 | 17-15 | 2 | 38,123 | Shawn Estes | Mike Thurman | Shawn Estes | Mike Thurman | | 161 | 173 | -12 |
| 2001-05-09 | vs MON | 33 | L 0-8 | 17-16 | 4 | 38,074 | Livan Hernandez | Javier Vazquez | Javier Vazquez | Livan Hernandez | | 161 | 181 | -20 |
| 2001-05-10 | vs MON | 34 | W 13-0 | 18-16 | 4 | 41,059 | Kirk Rueter | Britt Reames | Kirk Rueter | Britt Reames | | 174 | 181 | -7 |
| 2001-05-11 | vs NYN | 35 | W 3-2 | 19-16 | 3 | 41,059 | Mark Gardner | Steve Trachsel | Robb Nen | Donne Wall | | 177 | 183 | -6 |
| 2001-05-12 | vs NYN | 36 | W 10-3 | 20-16 | 2 | 41,059 | Russ Ortiz | Dicky Gonzalez | Russ Ortiz | Dicky Gonzalez | | 187 | 186 | 1 |
| 2001-05-13 | vs NYN | 37 | W 6-3 | 21-16 | 2 | 41,059 | Chad Zerbe | Kevin Appier | Chad Zerbe | Kevin Appier | | 193 | 189 | 4 |
| 2001-05-15 | @ FLO | 38 | W 7-4 | 22-16 | 1 | 10,389 | Livan Hernandez | Ryan Dempster | Livan Hernandez | Ryan Dempster | Robb Nen | 200 | 193 | 7 |
| 2001-05-16 | @ FLO | 39 | L 3-4 | 22-17 | 2 | 9,233 | Kirk Rueter | Matt Clement | Matt Clement | Kirk Rueter | Antonio Alfonseca | 203 | 197 | 6 |
| 2001-05-17 | @ FLO | 40 | L 3-8 | 22-18 | 3 | 10,433 | Russ Ortiz | Chuck Smith | Chuck Smith | Russ Ortiz | | 206 | 205 | 1 |
| 2001-05-18 | @ ATL | 41 | L 5-6 | 22-19 | 3 | 34,429 | Mark Gardner | Greg Maddux | Jose Cabrera | Robb Nen | | 211 | 211 | 0 |
| 2001-05-19 | @ ATL | 42 | W 6-3 | 23-19 | 3 | 42,789 | Ryan Jensen | Odalis Perez | Tim Worrell | Jose Cabrera | Robb Nen | 217 | 214 | 3 |
| 2001-05-20 | @ ATL | 43 | L 6-11 | 23-20 | 3 | 33,696 | Livan Hernandez | John Burkett | Kerry Ligtenberg | Livan Hernandez | | 223 | 225 | -2 |
| 2001-05-21 | @ ARI | 44 | L 2-4 | 23-21 | 4 | 28,628 | Kirk Rueter | Curt Schilling | Curt Schilling | Kirk Rueter | | 225 | 229 | -4 |
| 2001-05-22 | @ ARI | 45 | L 8-12 | 23-22 | 5 | 33,323 | Russ Ortiz | Brian Anderson | Brian Anderson | Russ Ortiz | | 233 | 241 | -8 |
| 2001-05-23 | @ ARI | 46 | W 5-1 | 24-22 | 4 | 34,922 | Mark Gardner | Randy Johnson | Mark Gardner | Randy Johnson | | 238 | 242 | -4 |
| 2001-05-24 | vs COL | 47 | W 5-1 | 25-22 | 4 | 40,856 | Shawn Estes | John Thomson | Shawn Estes | John Thomson | | 243 | 243 | 0 |
| 2001-05-25 | vs COL | 48 | L 1-6 | 25-23 | 4 | 41,341 | Livan Hernandez | Mike Hampton | Mike Hampton | Livan Hernandez | | 244 | 249 | -5 |
| 2001-05-26 | vs COL | 49 | L 4-10 | 25-24 | 5 | 41,341 | Kirk Rueter | Shawn Chacon | Shawn Chacon | Kirk Rueter | | 248 | 259 | -11 |
| 2001-05-27 | vs COL | 50 | W 5-4 | 26-24 | 4 | 41,341 | Russ Ortiz | Denny Neagle | Russ Ortiz | Denny Neagle | Robb Nen | 253 | 263 | -10 |
| 2001-05-28 | vs ARI | 51 | L 1-2 | 26-25 | 4 | 41,341 | Mark Gardner | Randy Johnson | Miguel Batista | Tim Worrell | | 254 | 265 | -11 |
| 2001-05-29 | vs ARI | 52 | L 0-1 | 26-26 | 5 | 39,709 | Shawn Estes | Armando Reynoso | Miguel Batista | Ryan Vogelsong | Greg Swindell | 254 | 266 | -12 |
| 2001-05-30 | vs ARI | 53 | L 3-4 | 26-27 | 5 | 40,313 | Livan Hernandez | Robert Ellis | Robert Ellis | Livan Hernandez | Bret Prinz | 257 | 270 | -13 |
| 2001-06-01 | @ COL | 54 | W 11-7 | 27-27 | 4 | 40,630 | Kirk Rueter | Shawn Chacon | Kirk Rueter | Shawn Chacon | | 268 | 277 | -9 |
| 2001-06-02 | @ COL | 55 | L 5-7 | 27-28 | 5 | 40,657 | Russ Ortiz | Denny Neagle | Jose Jimenez | Robb Nen | | 273 | 284 | -11 |
| 2001-06-03 | @ COL | 56 | L 2-11 | 27-29 | 5 | 41,684 | Mark Gardner | Pedro Astacio | Pedro Astacio | Mark Gardner | | 275 | 295 | -20 |
| 2001-06-04 | vs SDN | 57 | W 3-1 | 28-29 | 4 | 38,255 | Shawn Estes | Bobby Jones | Shawn Estes | Bobby Jones | Robb Nen | 278 | 296 | -18 |
| 2001-06-05 | vs SDN | 58 | W 7-6 | 29-29 | 4 | 38,476 | Livan Hernandez | Wascar Serrano | Livan Hernandez | Tom Davey | Robb Nen | 285 | 302 | -17 |
| 2001-06-06 | vs SDN | 59 | W 6-4 | 30-29 | 4 | 37,208 | Kirk Rueter | Woody Williams | Kirk Rueter | Woody Williams | Robb Nen | 291 | 306 | -15 |
| 2001-06-07 | vs SDN | 60 | L 7-10 | 30-30 | 4 | 40,898 | Russ Ortiz | Adam Eaton | Adam Eaton | Russ Ortiz | | 298 | 316 | -18 |
| 2001-06-08 | @ OAK | 61 | L 2-4 | 30-31 | 4 | 41,904 | Mark Gardner | Gil Heredia | Gil Heredia | Mark Gardner | Jason Isringhausen | 300 | 320 | -20 |
| 2001-06-09 | @ OAK | 62 | W 4-3 | 31-31 | 4 | 50,273 | Shawn Estes | Cory Lidle | Felix Rodriguez | T.J. Mathews | Robb Nen | 304 | 323 | -19 |
| 2001-06-10 | @ OAK | 63 | L 2-6 | 31-32 | 4 | 47,859 | Livan Hernandez | Mark Mulder | Mark Mulder | Livan Hernandez | Chad Bradford | 306 | 329 | -23 |
| 2001-06-12 | vs ANA | 64 | W 3-2 | 32-32 | 4 | 36,422 | Kirk Rueter | Pat Rapp | Kirk Rueter | Pat Rapp | Robb Nen | 309 | 331 | -22 |
| 2001-06-13 | vs ANA | 65 | W 1-0 | 33-32 | 4 | 37,119 | Russ Ortiz | Scott Schoeneweis | Russ Ortiz | Scott Schoeneweis | Robb Nen | 310 | 331 | -21 |
| 2001-06-14 | vs ANA | 66 | W 10-4 | 34-32 | 3 | 40,478 | Mark Gardner | Ismael Valdez | Mark Gardner | Ismael Valdez | | 320 | 335 | -15 |
| 2001-06-15 | vs OAK | 67 | W 3-1 | 35-32 | 3 | 40,849 | Shawn Estes | Mark Mulder | Shawn Estes | Mark Mulder | Robb Nen | 323 | 336 | -13 |
| 2001-06-16 | vs OAK | 68 | W 2-1 | 36-32 | 3 | 41,094 | Livan Hernandez | Cory Lidle | Livan Hernandez | Jeff Tam | Robb Nen | 325 | 337 | -12 |
| 2001-06-17 | vs OAK | 69 | W 3-0 | 37-32 | 3 | 41,506 | Kirk Rueter | Tim Hudson | Kirk Rueter | Tim Hudson | Robb Nen | 328 | 337 | -9 |
| 2001-06-19 | @ SDN | 70 | L 3-4 | 37-33 | 3 | 23,033 | Russ Ortiz | Adam Eaton | Jay Witasick | Ryan Vogelsong | | 331 | 341 | -10 |
| 2001-06-20 | @ SDN | 71 | W 8-6 | 38-33 | 3 | 23,167 | Mark Gardner | Kevin Jarvis | Mark Gardner | Kevin Jarvis | Robb Nen | 339 | 347 | -8 |
| 2001-06-21 | @ SDN | 72 | W 8-3 | 39-33 | 2 | 21,906 | Shawn Estes | Bobby Jones | Shawn Estes | Bobby Jones | | 347 | 350 | -3 |
| 2001-06-22 | @ SLN | 73 | W 10-5 | 40-33 | 2 | 40,845 | Livan Hernandez | Dustin Hermanson | Livan Hernandez | Dustin Hermanson | | 357 | 355 | 2 |
| 2001-06-23 | @ SLN | 74 | L 5-6 | 40-34 | 2 | 48,517 | Kirk Rueter | Darryl Kile | Jason Christiansen | Alan Embree | | 362 | 361 | 1 |
| 2001-06-24 | @ SLN | 75 | L 3-7 | 40-35 | 2 | 48,203 | Russ Ortiz | Matt Morris | Matt Morris | Russ Ortiz | Dave Veres | 365 | 368 | -3 |
| 2001-06-25 | vs LAN | 76 | W 5-2 | 41-35 | 2 | 40,942 | Mark Gardner | Chan Ho Park | Mark Gardner | Chan Ho Park | Robb Nen | 370 | 370 | 0 |
| 2001-06-26 | vs LAN | 77 | L 8-14 | 41-36 | 2 | 41,288 | Shawn Estes | Kevin Brown | Alberto Reyes | Tim Worrell | | 378 | 384 | -6 |
| 2001-06-27 | vs LAN | 78 | L 3-7 | 41-37 | 2 | 41,161 | Livan Hernandez | Terry Adams | Terry Adams | Livan Hernandez | | 381 | 391 | -10 |
| 2001-06-29 | vs SLN | 79 | W 3-2 | 42-37 | 3 | 41,738 | Kirk Rueter | Darryl Kile | Felix Rodriguez | Steve Kline | Robb Nen | 384 | 393 | -9 |
| 2001-06-30 | vs SLN | 80 | W 5-2 | 43-37 | 3 | 41,341 | Russ Ortiz | Matt Morris | Felix Rodriguez | Mike Timlin | Robb Nen | 389 | 395 | -6 |
| 2001-07-01 | vs SLN | 81 | W 5-4 | 44-37 | 3 | 41,705 | Mark Gardner | Andy Benes | Chad Zerbe | Andy Benes | Robb Nen | 394 | 399 | -5 |
| 2001-07-02 | @ LAN | 82 | L 6-8 | 44-38 | 3 | 30,464 | Shawn Estes | Terry Adams | Terry Adams | Ryan Vogelsong | Jeff Shaw | 400 | 407 | -7 |
| 2001-07-03 | @ LAN | 83 | L 3-4 | 44-39 | 3 | 36,948 | Livan Hernandez | Luke Prokopec | Jeff Williams | Livan Hernandez | Jeff Shaw | 403 | 411 | -8 |
| 2001-07-04 | @ LAN | 84 | L 3-4 | 44-40 | 3 | 54,636 | Kirk Rueter | Eric Gagne | Matt Herges | Felix Rodriguez | Jeff Shaw | 406 | 415 | -9 |
| 2001-07-05 | @ LAN | 85 | W 3-2 | 45-40 | 3 | 35,063 | Russ Ortiz | Chan Ho Park | Russ Ortiz | Alberto Reyes | Robb Nen | 409 | 417 | -8 |
| 2001-07-06 | vs MIL | 86 | W 3-2 | 46-40 | 3 | 41,604 | Mark Gardner | Allen Levrault | Chad Zerbe | Curt Leskanic | | 412 | 419 | -7 |
| 2001-07-07 | vs MIL | 87 | L 3-13 | 46-41 | 3 | 41,707 | Shawn Estes | Jimmy Haynes | Jimmy Haynes | Shawn Estes | Mike Buddie | 415 | 432 | -17 |
| 2001-07-08 | vs MIL | 88 | L 4-6 | 46-42 | 3 | 41,780 | Livan Hernandez | Jamey Wright | Mike DeJean | Brian Boehringer | | 419 | 438 | -19 |
| 2001-07-12 | @ SEA | 89 | L 3-4 | 46-43 | 3 | 45,696 | Kirk Rueter | Paul Abbott | Arthur Rhodes | Brian Boehringer | | 422 | 442 | -20 |
| 2001-07-13 | @ SEA | 90 | W 5-3 | 47-43 | 3 | 45,909 | Russ Ortiz | Jamie Moyer | Russ Ortiz | Jamie Moyer | Robb Nen | 427 | 445 | -18 |
| 2001-07-14 | @ SEA | 91 | L 2-3 | 47-44 | 3 | 45,809 | Shawn Estes | Freddy Garcia | Freddy Garcia | Shawn Estes | Kazuhiro Sasaki | 429 | 448 | -19 |
| 2001-07-15 | @ TEX | 92 | W 7-6 | 48-44 | 3 | 42,082 | Livan Hernandez | Darren Oliver | Livan Hernandez | Darren Oliver | Robb Nen | 436 | 454 | -18 |
| 2001-07-16 | @ TEX | 93 | L 0-2 | 48-45 | 3 | 32,682 | Ryan Jensen | Rob Bell | Rob Bell | Ryan Jensen | Jeff Zimmerman | 436 | 456 | -20 |
| 2001-07-17 | @ TEX | 94 | W 10-2 | 49-45 | 3 | 31,162 | Kirk Rueter | Kenny Rogers | Kirk Rueter | Kenny Rogers | | 446 | 458 | -12 |
| 2001-07-18 | vs COL | 95 | W 10-0 | 50-45 | 3 | 41,584 | Russ Ortiz | Mike Hampton | Russ Ortiz | Mike Hampton | | 456 | 458 | -2 |
| 2001-07-19 | vs COL | 96 | W 2-1 | 51-45 | 3 | 40,850 | Shawn Estes | Shawn Chacon | Felix Rodriguez | Juan Acevedo | | 458 | 459 | -1 |
| 2001-07-20 | vs ARI | 97 | W 1-0 | 52-45 | 3 | 41,287 | Livan Hernandez | Miguel Batista | Livan Hernandez | Miguel Batista | Robb Nen | 459 | 459 | 0 |
| 2001-07-21 | vs ARI | 98 | L 2-9 | 52-46 | 3 | 41,669 | Ryan Jensen | Curt Schilling | Curt Schilling | Ryan Jensen | | 461 | 468 | -7 |
| 2001-07-22 | vs ARI | 99 | L 4-12 | 52-47 | 3 | 41,901 | Kirk Rueter | Brian Anderson | Brian Anderson | Kirk Rueter | | 465 | 480 | -15 |
| 2001-07-23 | @ COL | 100 | L 2-8 | 52-48 | 3 | 37,424 | Russ Ortiz | Mike Hampton | Mike Hampton | Russ Ortiz | | 467 | 488 | -21 |
| 2001-07-24 | @ COL | 101 | L 4-6 | 52-49 | 3 | 40,132 | Shawn Estes | Shawn Chacon | Shawn Chacon | Shawn Estes | Jose Jimenez | 471 | 494 | -23 |
| 2001-07-25 | @ COL | 102 | W 9-3 | 53-49 | 3 | 42,088 | Ryan Jensen | Brian Bohanon | Ryan Jensen | Brian Bohanon | | 480 | 497 | -17 |
| 2001-07-26 | @ ARI | 103 | W 11-3 | 54-49 | 3 | 33,666 | Livan Hernandez | Curt Schilling | Livan Hernandez | Curt Schilling | | 491 | 500 | -9 |
| 2001-07-27 | @ ARI | 104 | W 9-5 | 55-49 | 3 | 35,853 | Kirk Rueter | Brian Anderson | Kirk Rueter | Brian Anderson | | 500 | 505 | -5 |
| 2001-07-28 | @ ARI | 105 | W 11-4 | 56-49 | 3 | 47,570 | Russ Ortiz | Albie Lopez | Russ Ortiz | Albie Lopez | | 511 | 509 | 2 |
| 2001-07-29 | @ ARI | 106 | W 4-3 | 57-49 | 3 | 38,093 | Shawn Estes | Randy Johnson | Shawn Estes | Byung-Hyun Kim | Robb Nen | 515 | 512 | 3 |
| 2001-07-31 | vs PIT | 107 | W 8-7 | 58-49 | 3 | 41,529 | Livan Hernandez | David Williams | Wayne Gomes | Marc Wilkins | | 523 | 519 | 4 |
| 2001-08-01 | vs PIT | 108 | W 3-1 | 59-49 | 3 | 41,251 | Jason Schmidt | Joe Beimel | Jason Schmidt | Joe Beimel | Robb Nen | 526 | 520 | 6 |
| 2001-08-02 | vs PIT | 109 | W 3-0 | 60-49 | 3 | 41,726 | Kirk Rueter | Tony McKnight | Kirk Rueter | Tony McKnight | Robb Nen | 529 | 520 | 9 |
| 2001-08-03 | vs PHI | 110 | W 4-2 | 61-49 | 3 | 41,679 | Russ Ortiz | Omar Daal | Felix Rodriguez | Rheal Cormier | | 533 | 522 | 11 |
| 2001-08-04 | vs PHI | 111 | L 2-12 | 61-50 | 3 | 41,720 | Shawn Estes | Nelson Figueroa | Nelson Figueroa | Shawn Estes | | 535 | 534 | 1 |
| 2001-08-05 | vs PHI | 112 | W 8-4 | 62-50 | 3 | 41,650 | Livan Hernandez | Robert Person | Livan Hernandez | Robert Person | | 543 | 538 | 5 |
| 2001-08-07 | @ CIN | 113 | W 9-3 | 63-50 | 2 | 23,588 | Kirk Rueter | Lance Davis | Jason Christiansen | Danny Graves | | 552 | 541 | 11 |
| 2001-08-08 | @ CIN | 114 | L 9-11 | 63-51 | 3 | 22,114 | Jason Schmidt | Elmer Dessens | Hector Mercado | Jason Schmidt | Danny Graves | 561 | 552 | 9 |
| 2001-08-09 | @ CIN | 115 | W 6-4 | 64-51 | 2 | 23,369 | Russ Ortiz | Scott Winchester | Russ Ortiz | Scott Winchester | Robb Nen | 567 | 556 | 11 |
| 2001-08-10 | @ CHN | 116 | L 3-9 | 64-52 | 3 | 40,529 | Shawn Estes | Jon Lieber | Jon Lieber | Shawn Estes | | 570 | 565 | 5 |
| 2001-08-11 | @ CHN | 117 | W 9-4 | 65-52 | 3 | 40,541 | Livan Hernandez | Joe Borowski | Livan Hernandez | Joe Borowski | | 579 | 569 | 10 |
| 2001-08-12 | @ CHN | 118 | W 7-6 | 66-52 | 2 | 40,314 | Kirk Rueter | Kevin Tapani | Kirk Rueter | Kevin Tapani | Robb Nen | 586 | 575 | 11 |
| 2001-08-14 | vs FLO | 119 | W 13-7 | 67-52 | 2 | 41,827 | Jason Schmidt | Jesus Sanchez | Jason Schmidt | Jesus Sanchez | | 599 | 582 | 17 |
| 2001-08-15 | vs FLO | 120 | W 2-1 | 68-52 | 2 | 41,278 | Russ Ortiz | Brad Penny | Robb Nen | Vic Darensbourg | | 601 | 583 | 18 |
| 2001-08-16 | vs FLO | 121 | W 5-3 | 69-52 | 2 | 41,804 | Shawn Estes | A.J. Burnett | Tim Worrell | A.J. Burnett | Robb Nen | 606 | 586 | 20 |
| 2001-08-17 | vs ATL | 122 | L 1-2 | 69-53 | 2 | 41,718 | Livan Hernandez | Greg Maddux | Greg Maddux | Livan Hernandez | John Smoltz | 607 | 588 | 19 |
| 2001-08-18 | vs ATL | 123 | L 1-3 | 69-54 | 2 | 41,722 | Kirk Rueter | Jason Marquis | Jason Marquis | Kirk Rueter | Steve Karsay | 608 | 591 | 17 |
| 2001-08-19 | vs ATL | 124 | W 4-1 | 70-54 | 2 | 41,527 | Jason Schmidt | Tom Glavine | Jason Schmidt | Tom Glavine | Robb Nen | 612 | 592 | 20 |
| 2001-08-21 | @ MON | 125 | W 10-2 | 71-54 | 2 | 8,937 | Russ Ortiz | Carl Pavano | Russ Ortiz | Carl Pavano | | 622 | 594 | 28 |
| 2001-08-22 | @ MON | 126 | L 1-7 | 71-55 | 2 | 8,217 | Shawn Estes | Javier Vazquez | Javier Vazquez | Shawn Estes | | 623 | 601 | 22 |
| 2001-08-23 | @ MON | 127 | W 10-5 | 72-55 | 2 | 7,990 | Livan Hernandez | Tomo Ohka | Felix Rodriguez | Graeme Lloyd | | 633 | 606 | 27 |
| 2001-08-24 | @ NYN | 128 | L 3-4 | 72-56 | 2 | 35,973 | Kirk Rueter | Bruce Chen | Bruce Chen | Kirk Rueter | Armando Benitez | 636 | 610 | 26 |
| 2001-08-25 | @ NYN | 129 | L 2-3 | 72-57 | 2 | 48,298 | Jason Schmidt | Steve Trachsel | Jerrod Riggan | Robb Nen | | 638 | 613 | 25 |
| 2001-08-26 | @ NYN | 130 | L 5-6 | 72-58 | 2 | 36,061 | Russ Ortiz | Al Leiter | Al Leiter | Russ Ortiz | Armando Benitez | 643 | 619 | 24 |
| 2001-08-27 | @ NYN | 131 | W 6-5 | 73-58 | 2 | 27,084 | Ryan Jensen | Kevin Appier | Felix Rodriguez | Rick White | Robb Nen | 649 | 624 | 25 |
| 2001-08-28 | @ ARI | 132 | L 1-4 | 73-59 | 2 | 41,502 | Livan Hernandez | Randy Johnson | Randy Johnson | Livan Hernandez | Byung-Hyun Kim | 650 | 628 | 22 |
| 2001-08-29 | @ ARI | 133 | L 0-2 | 73-60 | 2 | 31,990 | Kirk Rueter | Bobby Witt | Bobby Witt | Kirk Rueter | Byung-Hyun Kim | 650 | 630 | 20 |
| 2001-08-30 | @ ARI | 134 | W 13-5 | 74-60 | 2 | 34,269 | Jason Schmidt | Miguel Batista | Jason Schmidt | Miguel Batista | | 663 | 635 | 28 |
| 2001-08-31 | vs COL | 135 | L 2-5 | 74-61 | 2 | 41,081 | Russ Ortiz | John Thomson | John Thomson | Russ Ortiz | Jay Powell | 665 | 640 | 25 |
| 2001-09-01 | vs COL | 136 | W 2-1 | 75-61 | 2 | 41,034 | Ryan Jensen | Mike Hampton | Robb Nen | Justin Speier | | 667 | 641 | 26 |
| 2001-09-02 | vs COL | 137 | W 3-1 | 76-61 | 2 | 41,812 | Livan Hernandez | Shawn Chacon | Livan Hernandez | Shawn Chacon | Robb Nen | 670 | 642 | 28 |
| 2001-09-03 | vs COL | 138 | L 1-4 | 76-62 | 2 | 41,528 | Kirk Rueter | Jason Jennings | Jason Jennings | Kirk Rueter | Jay Powell | 671 | 646 | 25 |
| 2001-09-04 | vs ARI | 139 | W 5-2 | 77-62 | 2 | 40,869 | Jason Schmidt | Bobby Witt | Jason Schmidt | Greg Swindell | Robb Nen | 676 | 648 | 28 |
| 2001-09-05 | vs ARI | 140 | L 2-7 | 77-63 | 2 | 40,972 | Russ Ortiz | Curt Schilling | Curt Schilling | Russ Ortiz | | 678 | 655 | 23 |
| 2001-09-06 | vs ARI | 141 | W 9-5 | 78-63 | 2 | 41,155 | Ryan Jensen | Albie Lopez | Aaron Fultz | Albie Lopez | | 687 | 660 | 27 |
| 2001-09-07 | @ COL | 142 | L 2-3 | 78-64 | 3 | 33,473 | Livan Hernandez | Shawn Chacon | Dan Miceli | Tim Worrell | | 689 | 663 | 26 |
| 2001-09-08 | @ COL | 143 | W 7-3 | 79-64 | 2 | 32,825 | Kirk Rueter | Jason Jennings | Kirk Rueter | Jason Jennings | | 696 | 666 | 30 |
| 2001-09-09 | @ COL | 144 | W 9-4 | 80-64 | 2 | 36,862 | Jason Schmidt | Scott Elarton | Wayne Gomes | Todd Belitz | | 705 | 670 | 35 |
| 2001-09-18 | vs HOU | 145 | L 2-3 | 80-65 | 2 | 40,901 | Russ Ortiz | Roy Oswalt | Mike Williams | Robb Nen | Billy Wagner | 707 | 673 | 34 |
| 2001-09-19 | vs HOU | 146 | L 3-10 | 80-66 | 2 | 40,322 | Livan Hernandez | Dave Mlicki | Dave Mlicki | Livan Hernandez | | 710 | 683 | 27 |
| 2001-09-20 | vs HOU | 147 | L 4-5 | 80-67 | 2 | 40,470 | Kirk Rueter | Wade Miller | Octavio Dotel | Robb Nen | Billy Wagner | 714 | 688 | 26 |
| 2001-09-21 | @ SDN | 148 | W 2-0 | 81-67 | 2 | 60,066 | Jason Schmidt | Brian Lawrence | Jason Schmidt | Brian Lawrence | Robb Nen | 716 | 688 | 28 |
| 2001-09-22 | @ SDN | 149 | L 3-4 | 81-68 | 2 | 60,870 | Shawn Estes | Bobby Jones | Trevor Hoffman | Brian Boehringer | | 719 | 692 | 27 |
| 2001-09-23 | @ SDN | 150 | W 11-2 | 82-68 | 2 | 35,247 | Russ Ortiz | Junior Herndon | Russ Ortiz | Junior Herndon | | 730 | 694 | 36 |
| 2001-09-24 | @ LAN | 151 | W 2-1 | 83-68 | 2 | 38,849 | Livan Hernandez | James Baldwin | Livan Hernandez | James Baldwin | Robb Nen | 732 | 695 | 37 |
| 2001-09-25 | @ LAN | 152 | L 5-9 | 83-69 | 2 | 40,874 | Kirk Rueter | Chan Ho Park | Chan Ho Park | Kirk Rueter | | 737 | 704 | 33 |
| 2001-09-26 | @ LAN | 153 | W 6-4 | 84-69 | 2 | 49,320 | Jason Schmidt | Terry Mulholland | Felix Rodriguez | Jeff Shaw | Robb Nen | 743 | 708 | 35 |
| 2001-09-28 | vs SDN | 154 | W 10-5 | 85-69 | 2 | 41,098 | Shawn Estes | Jason Middlebrook | Shawn Estes | Jason Middlebrook | | 753 | 713 | 40 |
| 2001-09-29 | vs SDN | 155 | W 3-1 | 86-69 | 2 | 41,383 | Russ Ortiz | Brett Jodie | Russ Ortiz | Chuck McElroy | Robb Nen | 756 | 714 | 42 |
| 2001-09-30 | vs SDN | 156 | L 4-5 | 86-70 | 2 | 41,669 | Livan Hernandez | Brian Tollberg | Brian Tollberg | Tim Worrell | Trevor Hoffman | 760 | 719 | 41 |
| 2001-10-02 | @ HOU | 157 | W 4-1 | 87-70 | 2 | 43,548 | Kirk Rueter | Shane Reynolds | Kirk Rueter | Shane Reynolds | Robb Nen | 764 | 720 | 44 |
| 2001-10-03 | @ HOU | 158 | W 11-8 | 88-70 | 2 | 43,630 | Jason Schmidt | Tim Redding | Jason Schmidt | Nelson Cruz | | 775 | 728 | 47 |
| 2001-10-04 | @ HOU | 159 | W 10-2 | 89-70 | 2 | 43,734 | Russ Ortiz | Dave Mlicki | Russ Ortiz | Dave Mlicki | Brian Boehringer | 785 | 730 | 55 |
| 2001-10-05 | vs LAN | 160 | L 10-11 | 89-71 | 2 | 41,730 | Shawn Estes | Chan Ho Park | Giovanni Carrara | Tim Worrell | Jeff Shaw | 795 | 741 | 54 |
| 2001-10-06 | vs LAN | 161 | L 2-6 | 89-72 | 2 | 41,636 | Livan Hernandez | James Baldwin | James Baldwin | Livan Hernandez | Jeff Shaw | 797 | 747 | 50 |
| 2001-10-07 | vs LAN | 162 | W 2-1 | 90-72 | 2 | 41,257 | Kirk Rueter | Dennis Springer | Mark Gardner | Dennis Springer | Robb Nen | 799 | 748 | 51 |