| 2001-04-02 | @ SFN | 1 | L 2-3 | 0-1 | 5 | 40,930 | Woody Williams | Livan Hernandez | Livan Hernandez | Woody Williams | Robb Nen | 2 | 3 | -1 |
| 2001-04-04 | @ SFN | 2 | L 7-8 | 0-2 | 5 | 40,930 | Kevin Jarvis | Kirk Rueter | Robb Nen | Jay Witasick | | 9 | 11 | -2 |
| 2001-04-05 | @ SFN | 3 | L 2-8 | 0-3 | 5 | 40,930 | Bobby Jones | Russ Ortiz | Russ Ortiz | Bobby Jones | | 11 | 19 | -8 |
| 2001-04-06 | @ COL | 4 | W 10-6 | 1-3 | 5 | 37,431 | Adam Eaton | Brian Bohanon | Adam Eaton | Brian Bohanon | | 21 | 25 | -4 |
| 2001-04-07 | @ COL | 5 | W 14-10 | 2-3 | 5 | 41,026 | Woody Williams | Mike Hampton | Woody Williams | Mike Myers | Trevor Hoffman | 35 | 35 | 0 |
| 2001-04-08 | @ COL | 6 | W 11-3 | 3-3 | 4 | 40,446 | Brian Tollberg | Ron Villone | Brian Tollberg | Horacio Estrada | | 46 | 38 | 8 |
| 2001-04-10 | vs SFN | 7 | L 6-11 | 3-4 | 5 | 61,277 | Kevin Jarvis | Russ Ortiz | Russ Ortiz | Kevin Jarvis | | 52 | 49 | 3 |
| 2001-04-11 | vs SFN | 8 | L 1-2 | 3-5 | 5 | 50,149 | Bobby Jones | Shawn Estes | Aaron Fultz | Trevor Hoffman | Robb Nen | 53 | 51 | 2 |
| 2001-04-12 | vs SFN | 9 | W 8-3 | 4-5 | 4 | 25,730 | Adam Eaton | Livan Hernandez | Adam Eaton | Livan Hernandez | | 61 | 54 | 7 |
| 2001-04-13 | vs LAN | 10 | W 5-4 | 5-5 | 3 | 29,883 | Woody Williams | Chan Ho Park | Trevor Hoffman | Matt Herges | | 66 | 58 | 8 |
| 2001-04-14 | vs LAN | 11 | W 5-4 | 6-5 | 2 | 50,750 | Brian Tollberg | Eric Gagne | Trevor Hoffman | Gregg Olson | | 71 | 62 | 9 |
| 2001-04-15 | vs LAN | 12 | L 4-5 | 6-6 | 4 | 23,852 | Kevin Jarvis | Kevin Brown | Kevin Brown | Rodney Myers | Jeff Shaw | 75 | 67 | 8 |
| 2001-04-17 | vs COL | 13 | L 5-9 | 6-7 | 4 | 16,615 | Bobby Jones | Pedro Astacio | Pedro Astacio | Bobby Jones | Jose Jimenez | 80 | 76 | 4 |
| 2001-04-18 | vs COL | 14 | L 0-8 | 6-8 | 4 | 17,040 | Adam Eaton | Mike Hampton | Mike Hampton | Adam Eaton | | 80 | 84 | -4 |
| 2001-04-19 | vs COL | 15 | L 0-4 | 6-9 | 5 | 15,896 | Woody Williams | Denny Neagle | Denny Neagle | Woody Williams | | 80 | 88 | -8 |
| 2001-04-20 | @ LAN | 16 | L 1-3 | 6-10 | 5 | 34,368 | Brian Tollberg | Kevin Brown | Kevin Brown | Brian Tollberg | Jeff Shaw | 81 | 91 | -10 |
| 2001-04-21 | @ LAN | 17 | L 2-4 | 6-11 | 5 | 30,295 | Kevin Jarvis | Luke Prokopec | Luke Prokopec | Kevin Jarvis | Jeff Shaw | 83 | 95 | -12 |
| 2001-04-22 | @ LAN | 18 | W 7-6 | 7-11 | 5 | 31,040 | Bobby Jones | Darren Dreifort | Jay Witasick | Jeff Shaw | Rodney Myers | 90 | 101 | -11 |
| 2001-04-23 | vs PHI | 19 | L 3-5 | 7-12 | 5 | 42,932 | Adam Eaton | Bruce Chen | Bruce Chen | Adam Eaton | Ricky Bottalico | 93 | 106 | -13 |
| 2001-04-24 | vs PHI | 20 | L 7-12 | 7-13 | 5 | 13,872 | Woody Williams | Randy Wolf | Randy Wolf | Woody Williams | | 100 | 118 | -18 |
| 2001-04-25 | vs PHI | 21 | L 3-5 | 7-14 | 5 | 12,573 | Brian Tollberg | Omar Daal | Omar Daal | Brian Tollberg | Jose Mesa | 103 | 123 | -20 |
| 2001-04-26 | vs PHI | 22 | W 11-0 | 8-14 | 5 | 12,785 | Kevin Jarvis | Robert Person | Kevin Jarvis | Robert Person | | 114 | 123 | -9 |
| 2001-04-27 | vs PIT | 23 | L 0-3 | 8-15 | 5 | 27,896 | Bobby Jones | Jimmy Anderson | Jimmy Anderson | Bobby Jones | Mike Williams | 114 | 126 | -12 |
| 2001-04-28 | vs PIT | 24 | W 8-1 | 9-15 | 5 | 48,326 | Adam Eaton | Bronson Arroyo | Adam Eaton | Bronson Arroyo | | 122 | 127 | -5 |
| 2001-04-29 | vs PIT | 25 | W 6-1 | 10-15 | 5 | 41,654 | Woody Williams | Omar Olivares | Woody Williams | Omar Olivares | Trevor Hoffman | 128 | 128 | 0 |
| 2001-05-01 | @ CHN | 26 | W 10-3 | 11-15 | 5 | 28,842 | Brian Tollberg | Jason Bere | Brian Tollberg | Jason Bere | | 138 | 131 | 7 |
| 2001-05-02 | @ CHN | 27 | L 3-8 | 11-16 | 5 | 27,016 | Kevin Jarvis | Jon Lieber | Jon Lieber | Kevin Jarvis | | 141 | 139 | 2 |
| 2001-05-03 | @ CHN | 28 | W 5-3 | 12-16 | 5 | 27,307 | Bobby Jones | Kerry Wood | Bobby Jones | Kerry Wood | Trevor Hoffman | 146 | 142 | 4 |
| 2001-05-04 | @ CIN | 29 | W 11-5 | 13-16 | 5 | 24,630 | Adam Eaton | Elmer Dessens | Adam Eaton | Elmer Dessens | | 157 | 147 | 10 |
| 2001-05-05 | @ CIN | 30 | W 5-2 | 14-16 | 5 | 23,975 | Woody Williams | Rob Bell | Woody Williams | Rob Bell | Trevor Hoffman | 162 | 149 | 13 |
| 2001-05-06 | @ CIN | 31 | W 8-2 | 15-16 | 5 | 25,929 | Brian Tollberg | Osvaldo Fernandez | Brian Tollberg | Osvaldo Fernandez | | 170 | 151 | 19 |
| 2001-05-08 | vs ATL | 32 | W 7-1 | 16-16 | 5 | 20,494 | Kevin Jarvis | Greg Maddux | Kevin Jarvis | Greg Maddux | | 177 | 152 | 25 |
| 2001-05-09 | vs ATL | 33 | L 0-3 | 16-17 | 5 | 18,902 | Bobby Jones | John Burkett | John Burkett | Bobby Jones | John Rocker | 177 | 155 | 22 |
| 2001-05-10 | vs ATL | 34 | W 6-5 | 17-17 | 5 | 20,056 | Adam Eaton | Tom Glavine | Rodney Myers | Mike Remlinger | Trevor Hoffman | 183 | 160 | 23 |
| 2001-05-11 | vs FLO | 35 | W 7-6 | 18-17 | 5 | 24,357 | Woody Williams | Chuck Smith | Jay Witasick | Braden Looper | | 190 | 166 | 24 |
| 2001-05-12 | vs FLO | 36 | L 0-3 | 18-18 | 5 | 41,811 | Wascar Serrano | A.J. Burnett | A.J. Burnett | Wascar Serrano | | 190 | 169 | 21 |
| 2001-05-13 | vs FLO | 37 | L 4-10 | 18-19 | 5 | 25,781 | Kevin Jarvis | Brad Penny | Brad Penny | Jay Witasick | | 194 | 179 | 15 |
| 2001-05-15 | @ NYN | 38 | L 0-1 | 18-20 | 5 | 21,490 | Bobby Jones | Rick Reed | Rick Reed | Bobby Jones | Armando Benitez | 194 | 180 | 14 |
| 2001-05-16 | @ NYN | 39 | W 5-2 | 19-20 | 5 | 20,134 | Adam Eaton | Glendon Rusch | Adam Eaton | Glendon Rusch | Trevor Hoffman | 199 | 182 | 17 |
| 2001-05-17 | @ NYN | 40 | W 15-3 | 20-20 | 5 | 18,476 | Woody Williams | Steve Trachsel | Woody Williams | Steve Trachsel | | 214 | 185 | 29 |
| 2001-05-18 | @ MON | 41 | L 1-3 | 20-21 | 5 | 6,851 | Kevin Jarvis | Mike Thurman | Mike Thurman | Kevin Jarvis | Ugueth Urbina | 215 | 188 | 27 |
| 2001-05-19 | @ MON | 42 | W 20-7 | 21-21 | 4 | 7,297 | Wascar Serrano | Masato Yoshii | Wascar Serrano | Masato Yoshii | | 235 | 195 | 40 |
| 2001-05-20 | @ MON | 43 | W 5-3 | 22-21 | 4 | 7,269 | Bobby Jones | Javier Vazquez | Bobby Jones | Javier Vazquez | Trevor Hoffman | 240 | 198 | 42 |
| 2001-05-21 | @ HOU | 44 | W 7-6 | 23-21 | 3 | 28,119 | Adam Eaton | Shane Reynolds | Adam Eaton | Shane Reynolds | Trevor Hoffman | 247 | 204 | 43 |
| 2001-05-22 | @ HOU | 45 | W 6-2 | 24-21 | 2 | 31,094 | Woody Williams | Scott Elarton | Woody Williams | Scott Elarton | Jay Witasick | 253 | 206 | 47 |
| 2001-05-23 | @ HOU | 46 | W 7-6 | 25-21 | 2 | 34,225 | Kevin Jarvis | Kent Bottenfield | Jay Witasick | Billy Wagner | Trevor Hoffman | 260 | 212 | 48 |
| 2001-05-24 | vs ARI | 47 | W 3-1 | 26-21 | 1 | 19,450 | Wascar Serrano | Miguel Batista | Wascar Serrano | Troy Brohawn | Trevor Hoffman | 263 | 213 | 50 |
| 2001-05-25 | vs ARI | 48 | L 1-7 | 26-22 | 3 | 29,965 | Bobby Jones | Robert Ellis | Erik Sabel | Bobby Jones | | 264 | 220 | 44 |
| 2001-05-26 | vs ARI | 49 | L 1-3 | 26-23 | 3 | 49,300 | Adam Eaton | Curt Schilling | Curt Schilling | Adam Eaton | | 265 | 223 | 42 |
| 2001-05-27 | vs ARI | 50 | L 4-6 | 26-24 | 3 | 34,053 | Woody Williams | Brian Anderson | Greg Swindell | Trevor Hoffman | Bret Prinz | 269 | 229 | 40 |
| 2001-05-29 | vs HOU | 51 | W 5-4 | 27-24 | 3 | 16,560 | Kevin Jarvis | Kent Bottenfield | Kevin Jarvis | Kent Bottenfield | Trevor Hoffman | 274 | 233 | 41 |
| 2001-05-30 | vs HOU | 52 | L 4-7 | 27-25 | 3 | 19,098 | Bobby Jones | Wade Miller | Wade Miller | Bobby Jones | Billy Wagner | 278 | 240 | 38 |
| 2001-05-31 | vs HOU | 53 | L 4-8 | 27-26 | 3 | 18,021 | Wascar Serrano | Shane Reynolds | Shane Reynolds | Wascar Serrano | | 282 | 248 | 34 |
| 2001-06-01 | @ ARI | 54 | L 2-4 | 27-27 | 3 | 32,234 | Woody Williams | Curt Schilling | Curt Schilling | Woody Williams | Byung-Hyun Kim | 284 | 252 | 32 |
| 2001-06-02 | @ ARI | 55 | L 1-2 | 27-28 | 4 | 34,325 | Adam Eaton | Brian Anderson | Bret Prinz | Tom Davey | | 285 | 254 | 31 |
| 2001-06-03 | @ ARI | 56 | L 4-8 | 27-29 | 4 | 37,500 | Kevin Jarvis | Randy Johnson | Randy Johnson | Kevin Jarvis | | 289 | 262 | 27 |
| 2001-06-04 | @ SFN | 57 | L 1-3 | 27-30 | 5 | 38,255 | Bobby Jones | Shawn Estes | Shawn Estes | Bobby Jones | Robb Nen | 290 | 265 | 25 |
| 2001-06-05 | @ SFN | 58 | L 6-7 | 27-31 | 5 | 38,476 | Wascar Serrano | Livan Hernandez | Livan Hernandez | Tom Davey | Robb Nen | 296 | 272 | 24 |
| 2001-06-06 | @ SFN | 59 | L 4-6 | 27-32 | 5 | 37,208 | Woody Williams | Kirk Rueter | Kirk Rueter | Woody Williams | Robb Nen | 300 | 278 | 22 |
| 2001-06-07 | @ SFN | 60 | W 10-7 | 28-32 | 5 | 40,898 | Adam Eaton | Russ Ortiz | Adam Eaton | Russ Ortiz | | 310 | 285 | 25 |
| 2001-06-08 | @ SEA | 61 | L 1-7 | 28-33 | 5 | 45,293 | Kevin Jarvis | Paul Abbott | Paul Abbott | Kevin Jarvis | | 311 | 292 | 19 |
| 2001-06-09 | @ SEA | 62 | W 6-3 | 29-33 | 5 | 45,322 | Bobby Jones | Freddy Garcia | Bobby Jones | Freddy Garcia | Trevor Hoffman | 317 | 295 | 22 |
| 2001-06-10 | @ SEA | 63 | L 1-8 | 29-34 | 5 | 45,418 | Carlton Loewer | John Halama | John Halama | Carlton Loewer | | 318 | 303 | 15 |
| 2001-06-12 | vs OAK | 64 | L 2-5 | 29-35 | 5 | 20,793 | Woody Williams | Tim Hudson | Tim Hudson | Woody Williams | Jason Isringhausen | 320 | 308 | 12 |
| 2001-06-13 | vs OAK | 65 | L 2-6 | 29-36 | 5 | 14,707 | Adam Eaton | Barry Zito | Mark Guthrie | Jose Nunez | Jeff Tam | 322 | 314 | 8 |
| 2001-06-14 | vs OAK | 66 | W 6-4 | 30-36 | 5 | 17,053 | Kevin Jarvis | Gil Heredia | Tom Davey | Jim Mecir | Trevor Hoffman | 328 | 318 | 10 |
| 2001-06-15 | vs SEA | 67 | L 4-8 | 30-37 | 5 | 60,918 | Bobby Jones | Freddy Garcia | Freddy Garcia | Bobby Jones | | 332 | 326 | 6 |
| 2001-06-16 | vs SEA | 68 | L 2-9 | 30-38 | 5 | 61,065 | Carlton Loewer | John Halama | John Halama | Carlton Loewer | | 334 | 335 | -1 |
| 2001-06-17 | vs SEA | 69 | W 11-9 | 31-38 | 5 | 36,027 | Woody Williams | Aaron Sele | Tom Davey | Jeff Nelson | Trevor Hoffman | 345 | 344 | 1 |
| 2001-06-19 | vs SFN | 70 | W 4-3 | 32-38 | 5 | 23,033 | Adam Eaton | Russ Ortiz | Jay Witasick | Ryan Vogelsong | | 349 | 347 | 2 |
| 2001-06-20 | vs SFN | 71 | L 6-8 | 32-39 | 5 | 23,167 | Kevin Jarvis | Mark Gardner | Mark Gardner | Kevin Jarvis | Robb Nen | 355 | 355 | 0 |
| 2001-06-21 | vs SFN | 72 | L 3-8 | 32-40 | 5 | 21,906 | Bobby Jones | Shawn Estes | Shawn Estes | Bobby Jones | | 358 | 363 | -5 |
| 2001-06-22 | @ LAN | 73 | W 9-6 | 33-40 | 5 | 35,169 | Woody Williams | Terry Adams | Jay Witasick | Matt Herges | Trevor Hoffman | 367 | 369 | -2 |
| 2001-06-23 | @ LAN | 74 | W 6-2 | 34-40 | 5 | 45,130 | Brian Lawrence | Luke Prokopec | Brian Lawrence | Luke Prokopec | Rudy Seanez | 373 | 371 | 2 |
| 2001-06-24 | @ LAN | 75 | W 6-1 | 35-40 | 5 | 37,136 | Adam Eaton | Darren Dreifort | Adam Eaton | Darren Dreifort | | 379 | 372 | 7 |
| 2001-06-25 | @ COL | 76 | W 6-4 | 36-40 | 5 | 37,141 | Kevin Jarvis | Shawn Chacon | Kevin Jarvis | Gabe White | Trevor Hoffman | 385 | 376 | 9 |
| 2001-06-26 | @ COL | 77 | W 11-3 | 37-40 | 5 | 37,315 | Bobby Jones | Mike Hampton | Bobby Jones | Mike Hampton | | 396 | 379 | 17 |
| 2001-06-27 | @ COL | 78 | L 9-10 | 37-41 | 5 | 38,046 | Woody Williams | Brian Bohanon | Jose Jimenez | Tom Davey | | 405 | 389 | 16 |
| 2001-06-28 | vs LAN | 79 | L 4-7 | 37-42 | 5 | 21,221 | Brian Lawrence | Luke Prokopec | Giovanni Carrara | Rudy Seanez | Jeff Shaw | 409 | 396 | 13 |
| 2001-06-29 | vs LAN | 80 | L 5-7 | 37-43 | 5 | 31,793 | Adam Eaton | Darren Dreifort | Jeff Williams | Adam Eaton | Jeff Shaw | 414 | 403 | 11 |
| 2001-06-30 | vs LAN | 81 | L 3-7 | 37-44 | 5 | 60,830 | Kevin Jarvis | Chan Ho Park | Matt Herges | Trevor Hoffman | | 417 | 410 | 7 |
| 2001-07-01 | vs LAN | 82 | L 0-8 | 37-45 | 5 | 27,401 | Bobby Jones | Kevin Brown | Kevin Brown | Bobby Jones | Alberto Reyes | 417 | 418 | -1 |
| 2001-07-03 | vs COL | 83 | W 6-5 | 38-45 | 5 | 25,022 | Woody Williams | Shawn Chacon | Jose Nunez | Kane Davis | Trevor Hoffman | 423 | 423 | 0 |
| 2001-07-04 | vs COL | 84 | W 8-3 | 39-45 | 4 | 34,188 | Sterling Hitchcock | Mac Suzuki | Sterling Hitchcock | Mac Suzuki | | 431 | 426 | 5 |
| 2001-07-05 | vs COL | 85 | L 0-4 | 39-46 | 5 | 20,541 | Adam Eaton | Pedro Astacio | Pedro Astacio | Adam Eaton | | 431 | 430 | 1 |
| 2001-07-06 | vs TEX | 86 | W 8-3 | 40-46 | 4 | 24,549 | Kevin Jarvis | Rick Helling | Kevin Jarvis | Rick Helling | Trevor Hoffman | 439 | 433 | 6 |
| 2001-07-07 | vs TEX | 87 | L 3-4 | 40-47 | 4 | 44,707 | Bobby Jones | Doug Davis | Doug Davis | Bobby Jones | Jeff Zimmerman | 442 | 437 | 5 |
| 2001-07-08 | vs TEX | 88 | W 11-2 | 41-47 | 4 | 26,866 | Woody Williams | Darren Oliver | Woody Williams | Darren Oliver | | 453 | 439 | 14 |
| 2001-07-12 | @ HOU | 89 | W 7-4 | 42-47 | 4 | 31,597 | Bobby Jones | Shane Reynolds | Bobby Jones | Shane Reynolds | Trevor Hoffman | 460 | 443 | 17 |
| 2001-07-13 | @ HOU | 90 | L 3-11 | 42-48 | 4 | 34,020 | Woody Williams | Roy Oswalt | Roy Oswalt | Woody Williams | | 463 | 454 | 9 |
| 2001-07-14 | @ HOU | 91 | W 8-6 | 43-48 | 4 | 41,042 | Kevin Jarvis | Wade Miller | Kevin Jarvis | Wade Miller | Trevor Hoffman | 471 | 460 | 11 |
| 2001-07-15 | @ ANA | 92 | W 5-1 | 44-48 | 4 | 31,536 | Brian Lawrence | Ramon Ortiz | Brian Lawrence | Ramon Ortiz | | 476 | 461 | 15 |
| 2001-07-16 | @ ANA | 93 | L 5-7 | 44-49 | 4 | 19,456 | Brian Tollberg | Pat Rapp | Ben Weber | Brian Tollberg | Troy Percival | 481 | 468 | 13 |
| 2001-07-17 | @ ANA | 94 | L 7-8 | 44-50 | 4 | 30,181 | Bobby Jones | Scott Schoeneweis | Al Levine | Tom Davey | | 488 | 476 | 12 |
| 2001-07-18 | vs ARI | 95 | L 0-3 | 44-51 | 4 | 22,184 | Woody Williams | Curt Schilling | Randy Johnson | Woody Williams | | 488 | 479 | 9 |
| 2001-07-19 | vs ARI | 96 | W 8-4 | 45-51 | 4 | 22,583 | Kevin Jarvis | Robert Ellis | Kevin Jarvis | Robert Ellis | Trevor Hoffman | 496 | 483 | 13 |
| 2001-07-20 | vs MIL | 97 | W 11-2 | 46-51 | 4 | 24,924 | Sterling Hitchcock | Ben Sheets | Sterling Hitchcock | Ben Sheets | | 507 | 485 | 22 |
| 2001-07-21 | vs MIL | 98 | W 5-3 | 47-51 | 4 | 36,321 | Brian Tollberg | Mac Suzuki | Brian Tollberg | Mac Suzuki | Trevor Hoffman | 512 | 488 | 24 |
| 2001-07-22 | vs MIL | 99 | W 4-0 | 48-51 | 4 | 21,883 | Bobby Jones | Jimmy Haynes | Bobby Jones | Jimmy Haynes | | 516 | 488 | 28 |
| 2001-07-23 | @ ARI | 100 | W 4-2 | 49-51 | 4 | 28,687 | Woody Williams | Nick Bierbrodt | Woody Williams | Nick Bierbrodt | Trevor Hoffman | 520 | 490 | 30 |
| 2001-07-24 | @ ARI | 101 | L 0-11 | 49-52 | 4 | 36,940 | Kevin Jarvis | Randy Johnson | Randy Johnson | Kevin Jarvis | | 520 | 501 | 19 |
| 2001-07-25 | @ ARI | 102 | L 6-9 | 49-53 | 4 | 28,376 | Sterling Hitchcock | Miguel Batista | Miguel Batista | Sterling Hitchcock | Byung-Hyun Kim | 526 | 510 | 16 |
| 2001-07-27 | @ MIL | 103 | L 0-8 | 49-54 | 4 | 29,520 | Bobby Jones | Jimmy Haynes | Jimmy Haynes | Bobby Jones | | 526 | 518 | 8 |
| 2001-07-28 | @ MIL | 104 | W 6-2 | 50-54 | 4 | 42,096 | Woody Williams | Allen Levrault | Woody Williams | Allen Levrault | Trevor Hoffman | 532 | 520 | 12 |
| 2001-07-29 | @ MIL | 105 | W 12-5 | 51-54 | 4 | 42,189 | Kevin Jarvis | Jamey Wright | Kevin Jarvis | Jamey Wright | | 544 | 525 | 19 |
| 2001-07-31 | vs CHN | 106 | L 3-7 | 51-55 | 4 | 25,358 | Brian Lawrence | Jon Lieber | Jon Lieber | Brian Lawrence | | 547 | 532 | 15 |
| 2001-08-01 | vs CHN | 107 | W 4-3 | 52-55 | 4 | 24,115 | Bobby Jones | Kevin Tapani | Bobby Jones | Felix Heredia | Trevor Hoffman | 551 | 535 | 16 |
| 2001-08-02 | vs CHN | 108 | W 4-3 | 53-55 | 4 | 25,043 | Junior Herndon | Jason Bere | Chuck McElroy | Jeff Fassero | Trevor Hoffman | 555 | 538 | 17 |
| 2001-08-03 | vs CIN | 109 | L 2-9 | 53-56 | 4 | 27,769 | Kevin Jarvis | Jim Brower | Jim Brower | Kevin Jarvis | | 557 | 547 | 10 |
| 2001-08-04 | vs CIN | 110 | W 2-0 | 54-56 | 4 | 52,520 | Brian Tollberg | Chris Reitsma | Brian Tollberg | Chris Reitsma | Trevor Hoffman | 559 | 547 | 12 |
| 2001-08-05 | vs CIN | 111 | L 9-10 | 54-57 | 4 | 28,253 | Brian Lawrence | Jose Acevedo | Danny Graves | Rudy Seanez | | 568 | 557 | 11 |
| 2001-08-07 | @ PHI | 112 | L 3-7 | 54-58 | 4 | 19,465 | Bobby Jones | Brandon Duckworth | Brandon Duckworth | Bobby Jones | | 571 | 564 | 7 |
| 2001-08-08 | @ PHI | 113 | L 3-4 | 54-59 | 4 | 24,202 | Junior Herndon | Dave Coggin | Dave Coggin | Junior Herndon | Jose Mesa | 574 | 568 | 6 |
| 2001-08-09 | @ PHI | 114 | W 6-2 | 55-59 | 4 | 21,587 | Kevin Jarvis | Omar Daal | Kevin Jarvis | Omar Daal | | 580 | 570 | 10 |
| 2001-08-10 | @ PIT | 115 | W 3-2 | 56-59 | 4 | 36,588 | Brian Tollberg | David Williams | Brian Tollberg | David Williams | Trevor Hoffman | 583 | 572 | 11 |
| 2001-08-11 | @ PIT | 116 | W 6-2 | 57-59 | 4 | 39,388 | Brian Lawrence | Joe Beimel | Brian Lawrence | Joe Beimel | | 589 | 574 | 15 |
| 2001-08-12 | @ PIT | 117 | L 6-7 | 57-60 | 4 | 37,150 | Bobby Jones | Tony McKnight | Josias Manzanillo | Rodney Myers | | 595 | 581 | 14 |
| 2001-08-14 | vs NYN | 118 | W 6-0 | 58-60 | 4 | 24,803 | Junior Herndon | Steve Trachsel | Junior Herndon | Steve Trachsel | | 601 | 581 | 20 |
| 2001-08-15 | vs NYN | 119 | W 2-1 | 59-60 | 4 | 20,838 | Kevin Jarvis | Al Leiter | Kevin Jarvis | Al Leiter | Trevor Hoffman | 603 | 582 | 21 |
| 2001-08-16 | vs NYN | 120 | W 6-5 | 60-60 | 4 | 22,614 | Brian Tollberg | Kevin Appier | Jeremy Fikac | Rick White | Trevor Hoffman | 609 | 587 | 22 |
| 2001-08-17 | vs MON | 121 | L 0-4 | 60-61 | 4 | 22,513 | Brian Lawrence | Javier Vazquez | Javier Vazquez | Brian Lawrence | | 609 | 591 | 18 |
| 2001-08-18 | vs MON | 122 | W 4-3 | 61-61 | 4 | 31,485 | Bobby Jones | Mike Thurman | Bobby Jones | Mike Thurman | Trevor Hoffman | 613 | 594 | 19 |
| 2001-08-19 | vs MON | 123 | L 1-2 | 61-62 | 4 | 24,309 | Junior Herndon | Tony Armas | Tony Armas | Junior Herndon | Scott Strickland | 614 | 596 | 18 |
| 2001-08-21 | @ ATL | 124 | W 3-1 | 62-62 | 4 | 26,756 | Kevin Jarvis | John Burkett | Jose Nunez | Steve Karsay | Trevor Hoffman | 617 | 597 | 20 |
| 2001-08-22 | @ ATL | 125 | L 3-6 | 62-63 | 4 | 22,787 | Brian Tollberg | Greg Maddux | Greg Maddux | Brian Tollberg | Mike Remlinger | 620 | 603 | 17 |
| 2001-08-23 | @ ATL | 126 | L 2-3 | 62-64 | 4 | 26,043 | Brian Lawrence | Kevin Millwood | Kevin Millwood | Brian Lawrence | John Smoltz | 622 | 606 | 16 |
| 2001-08-24 | @ FLO | 127 | L 3-6 | 62-65 | 4 | 11,277 | Bobby Jones | Matt Clement | Matt Clement | Bobby Jones | Antonio Alfonseca | 625 | 612 | 13 |
| 2001-08-25 | @ FLO | 128 | W 7-1 | 63-65 | 4 | 16,322 | Junior Herndon | Jesus Sanchez | Junior Herndon | Jesus Sanchez | | 632 | 613 | 19 |
| 2001-08-26 | @ FLO | 129 | W 10-0 | 64-65 | 4 | 11,548 | Kevin Jarvis | Brad Penny | Kevin Jarvis | Brad Penny | | 642 | 613 | 29 |
| 2001-08-27 | @ FLO | 130 | W 8-3 | 65-65 | 4 | 9,294 | Brian Tollberg | A.J. Burnett | Brian Tollberg | A.J. Burnett | | 650 | 616 | 34 |
| 2001-08-28 | @ SLN | 131 | W 5-2 | 66-65 | 4 | 34,431 | Brian Lawrence | Darryl Kile | Brian Lawrence | Darryl Kile | Trevor Hoffman | 655 | 618 | 37 |
| 2001-08-29 | @ SLN | 132 | L 14-16 | 66-66 | 4 | 31,362 | Bobby Jones | Bud Smith | Gene Stechschulte | Bobby Jones | | 669 | 634 | 35 |
| 2001-08-30 | @ SLN | 133 | L 3-13 | 66-67 | 4 | 28,992 | Junior Herndon | Matt Morris | Matt Morris | Junior Herndon | | 672 | 647 | 25 |
| 2001-08-31 | vs ARI | 134 | L 1-4 | 67-68 | 4 | 0 | Brett Jodie | Curt Schilling | Curt Schilling | Brett Jodie | Bret Prinz | 673 | 651 | 22 |
| 2001-08-31 | vs ARI | 135 | W 6-5 | 67-68 | 4 | 24,372 | Kevin Jarvis | Brian Anderson | Jose Nunez | Bret Prinz | Trevor Hoffman | 679 | 656 | 23 |
| 2001-09-01 | vs ARI | 136 | W 7-5 | 68-68 | 4 | 34,252 | Brian Tollberg | Albie Lopez | David Lee | Byung-Hyun Kim | Trevor Hoffman | 686 | 661 | 25 |
| 2001-09-02 | vs ARI | 137 | W 1-0 | 69-68 | 4 | 23,475 | Brian Lawrence | Randy Johnson | Wascar Serrano | Byung-Hyun Kim | | 687 | 661 | 26 |
| 2001-09-03 | vs SLN | 138 | L 0-4 | 69-69 | 4 | 36,535 | Bobby Jones | Bud Smith | Bud Smith | Bobby Jones | | 687 | 665 | 22 |
| 2001-09-04 | vs SLN | 139 | L 1-6 | 69-70 | 4 | 16,304 | Junior Herndon | Matt Morris | Matt Morris | Junior Herndon | | 688 | 671 | 17 |
| 2001-09-05 | vs SLN | 140 | L 0-2 | 69-71 | 4 | 19,075 | Kevin Jarvis | Woody Williams | Woody Williams | Kevin Jarvis | | 688 | 673 | 15 |
| 2001-09-07 | @ ARI | 141 | W 4-3 | 70-71 | 4 | 32,184 | Brian Tollberg | Randy Johnson | Jeremy Fikac | Greg Swindell | Trevor Hoffman | 692 | 676 | 16 |
| 2001-09-08 | @ ARI | 142 | L 6-8 | 70-72 | 4 | 39,929 | Brian Lawrence | Brian Anderson | Byung-Hyun Kim | Wascar Serrano | | 698 | 684 | 14 |
| 2001-09-09 | @ ARI | 143 | L 2-8 | 70-73 | 4 | 33,741 | Bobby Jones | Bobby Witt | Bobby Witt | Bobby Jones | Byung-Hyun Kim | 700 | 692 | 8 |
| 2001-09-17 | @ LAN | 144 | W 6-4 | 71-73 | 4 | 40,676 | Jason Middlebrook | Kevin Brown | Jason Middlebrook | Chan Ho Park | Trevor Hoffman | 706 | 696 | 10 |
| 2001-09-18 | @ LAN | 145 | W 3-2 | 72-73 | 4 | 28,473 | Kevin Jarvis | Terry Adams | Kevin Jarvis | Terry Adams | Trevor Hoffman | 709 | 698 | 11 |
| 2001-09-19 | @ LAN | 146 | W 4-3 | 73-73 | 4 | 31,902 | Brian Tollberg | James Baldwin | Jose Nunez | Mike Trombley | Trevor Hoffman | 713 | 701 | 12 |
| 2001-09-21 | vs SFN | 147 | L 0-2 | 73-74 | 4 | 60,066 | Brian Lawrence | Jason Schmidt | Jason Schmidt | Brian Lawrence | Robb Nen | 713 | 703 | 10 |
| 2001-09-22 | vs SFN | 148 | W 4-3 | 74-74 | 4 | 60,870 | Bobby Jones | Shawn Estes | Trevor Hoffman | Brian Boehringer | | 717 | 706 | 11 |
| 2001-09-23 | vs SFN | 149 | L 2-11 | 74-75 | 4 | 35,247 | Junior Herndon | Russ Ortiz | Russ Ortiz | Junior Herndon | | 719 | 717 | 2 |
| 2001-09-24 | @ COL | 150 | L 11-15 | 74-76 | 4 | 30,774 | Kevin Jarvis | John Thomson | Justin Speier | David Lundquist | | 730 | 732 | -2 |
| 2001-09-25 | @ COL | 151 | W 8-7 | 75-76 | 4 | 31,193 | Brian Tollberg | Mike Hampton | Brian Tollberg | Mike Hampton | Trevor Hoffman | 738 | 739 | -1 |
| 2001-09-26 | @ COL | 152 | W 3-1 | 76-76 | 4 | 30,711 | Brian Lawrence | Shawn Chacon | Brian Lawrence | Justin Speier | Trevor Hoffman | 741 | 740 | 1 |
| 2001-09-27 | @ COL | 153 | L 9-13 | 76-77 | 4 | 31,162 | Bobby Jones | Jason Jennings | Todd Belitz | Junior Herndon | | 750 | 753 | -3 |
| 2001-09-28 | @ SFN | 154 | L 5-10 | 76-78 | 4 | 41,098 | Jason Middlebrook | Shawn Estes | Shawn Estes | Jason Middlebrook | | 755 | 763 | -8 |
| 2001-09-29 | @ SFN | 155 | L 1-3 | 76-79 | 4 | 41,383 | Brett Jodie | Russ Ortiz | Russ Ortiz | Chuck McElroy | Robb Nen | 756 | 766 | -10 |
| 2001-09-30 | @ SFN | 156 | W 5-4 | 77-79 | 4 | 41,669 | Brian Tollberg | Livan Hernandez | Brian Tollberg | Tim Worrell | Trevor Hoffman | 761 | 770 | -9 |
| 2001-10-02 | vs LAN | 157 | L 2-5 | 77-80 | 4 | 22,442 | Brian Lawrence | Terry Mulholland | Giovanni Carrara | Trevor Hoffman | Jeff Shaw | 763 | 775 | -12 |
| 2001-10-03 | vs LAN | 158 | L 5-12 | 77-81 | 4 | 23,138 | Bobby Jones | Eric Gagne | Eric Gagne | Bobby Jones | | 768 | 787 | -19 |
| 2001-10-04 | vs LAN | 159 | W 6-3 | 78-81 | 4 | 21,606 | Jason Middlebrook | Luke Prokopec | Jason Middlebrook | Luke Prokopec | Trevor Hoffman | 774 | 790 | -16 |
| 2001-10-05 | vs COL | 160 | L 0-4 | 78-82 | 4 | 27,646 | Kevin Jarvis | Jason Jennings | Jason Jennings | Kevin Jarvis | | 774 | 794 | -20 |
| 2001-10-06 | vs COL | 161 | W 10-4 | 79-82 | 4 | 30,637 | Brian Tollberg | Scott Elarton | Brian Tollberg | Scott Elarton | | 784 | 798 | -14 |
| 2001-10-07 | vs COL | 162 | L 5-14 | 79-83 | 4 | 60,103 | Brian Lawrence | John Thomson | John Thomson | Brian Lawrence | | 789 | 812 | -23 |