| 2001-04-03 | @ CIN | 1 | L 2-3 | 0-1 | 5 | 20,784 | Todd Ritchie | Osvaldo Fernandez | Osvaldo Fernandez | Todd Ritchie | Danny Graves | 2 | 3 | -1 |
| 2001-04-04 | @ CIN | 2 | W 6-5 | 1-1 | 2 | 18,330 | Terry Mulholland | Chris Reitsma | Mike Williams | Scott Sullivan | | 8 | 8 | 0 |
| 2001-04-05 | @ CIN | 3 | L 1-4 | 1-2 | 4 | 20,482 | Jimmy Anderson | Elmer Dessens | Elmer Dessens | Jimmy Anderson | John Riedling | 9 | 12 | -3 |
| 2001-04-06 | @ HOU | 4 | L 1-4 | 1-3 | 4 | 27,126 | Omar Olivares | Octavio Dotel | Octavio Dotel | Omar Olivares | Billy Wagner | 10 | 16 | -6 |
| 2001-04-07 | @ HOU | 5 | W 5-3 | 2-3 | 3 | 30,046 | Bronson Arroyo | Kent Bottenfield | Bronson Arroyo | Kent Bottenfield | Mike Williams | 15 | 19 | -4 |
| 2001-04-08 | @ HOU | 6 | W 9-3 | 3-3 | 3 | 30,174 | Joe Beimel | Scott Elarton | Joe Beimel | Scott Elarton | | 24 | 22 | 2 |
| 2001-04-09 | vs CIN | 7 | L 2-8 | 3-4 | 5 | 36,954 | Todd Ritchie | Chris Reitsma | Chris Reitsma | Todd Ritchie | | 26 | 30 | -4 |
| 2001-04-11 | vs CIN | 8 | W 6-5 | 4-4 | 4 | 35,045 | Jimmy Anderson | Elmer Dessens | Jose Silva | John Riedling | Mike Williams | 32 | 35 | -3 |
| 2001-04-12 | vs CIN | 9 | L 6-11 | 4-5 | 4 | 33,045 | Omar Olivares | Pete Harnisch | Pete Harnisch | Omar Olivares | | 38 | 46 | -8 |
| 2001-04-13 | @ CHN | 10 | L 2-4 | 4-6 | 5 | 26,003 | Bronson Arroyo | Jason Bere | Jason Bere | Bronson Arroyo | Jeff Fassero | 40 | 50 | -10 |
| 2001-04-14 | @ CHN | 11 | L 6-7 | 4-7 | 6 | 34,220 | Ramon Martinez | Jon Lieber | Manny Aybar | Jose Silva | Jeff Fassero | 46 | 57 | -11 |
| 2001-04-15 | @ CHN | 12 | L 1-5 | 4-8 | 6 | 21,061 | Todd Ritchie | Kerry Wood | Courtney Duncan | Scott Sauerbeck | | 47 | 62 | -15 |
| 2001-04-16 | vs HOU | 13 | W 3-0 | 5-8 | 6 | 20,128 | Jimmy Anderson | Wade Miller | Jimmy Anderson | Wade Miller | Mike Williams | 50 | 62 | -12 |
| 2001-04-18 | vs HOU | 14 | W 8-4 | 6-8 | 6 | 20,339 | Omar Olivares | Shane Reynolds | Bronson Arroyo | Shane Reynolds | | 58 | 66 | -8 |
| 2001-04-20 | vs CHN | 15 | L 2-8 | 6-9 | 6 | 31,692 | Ramon Martinez | Jon Lieber | Jon Lieber | Ramon Martinez | | 60 | 74 | -14 |
| 2001-04-21 | vs CHN | 16 | L 3-4 | 6-10 | 6 | 33,105 | Todd Ritchie | Kerry Wood | Felix Heredia | Mike Williams | Jeff Fassero | 63 | 78 | -15 |
| 2001-04-22 | vs CHN | 17 | W 4-3 | 7-10 | 6 | 35,676 | Jimmy Anderson | Julian Tavarez | Mike Williams | Jeff Fassero | | 67 | 81 | -14 |
| 2001-04-24 | @ LAN | 18 | W 5-1 | 8-10 | 6 | 23,596 | Omar Olivares | Chan Ho Park | Omar Olivares | Chan Ho Park | | 72 | 82 | -10 |
| 2001-04-25 | @ LAN | 19 | L 5-6 | 8-11 | 6 | 22,495 | Ramon Martinez | Eric Gagne | Terry Adams | Josias Manzanillo | | 77 | 88 | -11 |
| 2001-04-26 | @ LAN | 20 | L 3-6 | 8-12 | 6 | 24,143 | Todd Ritchie | Kevin Brown | Kevin Brown | Todd Ritchie | | 80 | 94 | -14 |
| 2001-04-27 | @ SDN | 21 | W 3-0 | 9-12 | 6 | 27,896 | Jimmy Anderson | Bobby Jones | Jimmy Anderson | Bobby Jones | Mike Williams | 83 | 94 | -11 |
| 2001-04-28 | @ SDN | 22 | L 1-8 | 9-13 | 6 | 48,326 | Bronson Arroyo | Adam Eaton | Adam Eaton | Bronson Arroyo | | 84 | 102 | -18 |
| 2001-04-29 | @ SDN | 23 | L 1-6 | 9-14 | 6 | 41,654 | Omar Olivares | Woody Williams | Woody Williams | Omar Olivares | Trevor Hoffman | 85 | 108 | -23 |
| 2001-05-01 | vs SFN | 24 | L 6-11 | 9-15 | 6 | 22,926 | Ramon Martinez | Kirk Rueter | Kirk Rueter | Ramon Martinez | | 91 | 119 | -28 |
| 2001-05-02 | vs SFN | 25 | L 6-7 | 9-16 | 6 | 22,880 | Todd Ritchie | Russ Ortiz | Russ Ortiz | Jose Silva | Robb Nen | 97 | 126 | -29 |
| 2001-05-03 | vs SFN | 26 | W 4-3 | 10-16 | 6 | 23,048 | Jimmy Anderson | Shawn Estes | Jose Silva | Shawn Estes | Mike Williams | 101 | 129 | -28 |
| 2001-05-04 | vs COL | 27 | L 3-9 | 10-17 | 6 | 32,653 | Bronson Arroyo | Mike Hampton | Mike Hampton | Bronson Arroyo | | 104 | 138 | -34 |
| 2001-05-05 | vs COL | 28 | W 11-3 | 11-17 | 6 | 37,596 | Omar Olivares | Shawn Chacon | Omar Olivares | Shawn Chacon | | 115 | 141 | -26 |
| 2001-05-06 | vs COL | 29 | W 4-3 | 12-17 | 6 | 34,915 | Don Wengert | Denny Neagle | Joe Beimel | Gabe White | | 119 | 144 | -25 |
| 2001-05-07 | @ SLN | 30 | L 0-7 | 12-18 | 6 | 31,891 | Todd Ritchie | Matt Morris | Matt Morris | Todd Ritchie | | 119 | 151 | -32 |
| 2001-05-08 | @ SLN | 31 | L 2-8 | 12-19 | 6 | 35,771 | Jimmy Anderson | Andy Benes | Andy Benes | Jimmy Anderson | | 121 | 159 | -38 |
| 2001-05-09 | @ SLN | 32 | L 2-6 | 12-20 | 6 | 33,921 | Bronson Arroyo | Dustin Hermanson | Dustin Hermanson | Bronson Arroyo | | 123 | 165 | -42 |
| 2001-05-10 | @ SLN | 33 | L 5-11 | 12-21 | 6 | 45,008 | Omar Olivares | Rick Ankiel | Mike Matthews | Jose Silva | | 128 | 176 | -48 |
| 2001-05-11 | @ MIL | 34 | W 3-0 | 13-21 | 6 | 31,525 | Jason Schmidt | Jimmy Haynes | Jason Schmidt | Jimmy Haynes | Mike Williams | 131 | 176 | -45 |
| 2001-05-12 | @ MIL | 35 | L 4-5 | 13-22 | 6 | 42,004 | Todd Ritchie | Paul Rigdon | Curt Leskanic | Joe Beimel | | 135 | 181 | -46 |
| 2001-05-13 | @ MIL | 36 | L 1-4 | 13-23 | 6 | 30,084 | Jimmy Anderson | Ben Sheets | Ben Sheets | Jimmy Anderson | | 136 | 185 | -49 |
| 2001-05-14 | @ MIL | 37 | L 8-11 | 13-24 | 6 | 26,974 | Don Wengert | Jamey Wright | Jamey Wright | Don Wengert | Curt Leskanic | 144 | 196 | -52 |
| 2001-05-15 | vs SLN | 38 | L 3-8 | 13-25 | 6 | 30,883 | Omar Olivares | Dustin Hermanson | Dustin Hermanson | Omar Olivares | | 147 | 204 | -57 |
| 2001-05-16 | vs SLN | 39 | L 0-3 | 13-26 | 6 | 29,128 | Jason Schmidt | Darryl Kile | Darryl Kile | Jason Schmidt | | 147 | 207 | -60 |
| 2001-05-17 | vs SLN | 40 | L 2-12 | 13-27 | 6 | 29,835 | Todd Ritchie | Matt Morris | Matt Morris | Todd Ritchie | | 149 | 219 | -70 |
| 2001-05-19 | vs MIL | 41 | W 6-1 | 14-27 | 6 | 37,857 | Jimmy Anderson | Ben Sheets | Jimmy Anderson | Ben Sheets | | 155 | 220 | -65 |
| 2001-05-20 | vs MIL | 42 | W 8-7 | 15-27 | 6 | 35,728 | Don Wengert | Jamey Wright | Josias Manzanillo | David Weathers | Mike Williams | 163 | 227 | -64 |
| 2001-05-23 | @ PHI | 43 | L 0-4 | 15-29 | 6 | 0 | Jason Schmidt | Randy Wolf | Randy Wolf | Jason Schmidt | Ricky Bottalico | 163 | 231 | -68 |
| 2001-05-23 | @ PHI | 44 | L 2-5 | 15-29 | 6 | 13,337 | Omar Olivares | Omar Daal | Omar Daal | Omar Olivares | Jose Mesa | 165 | 236 | -71 |
| 2001-05-24 | @ PHI | 45 | L 5-6 | 15-30 | 6 | 12,287 | Jimmy Anderson | Robert Person | Rheal Cormier | Scott Sauerbeck | Jose Mesa | 170 | 242 | -72 |
| 2001-05-25 | @ ATL | 46 | L 0-1 | 15-31 | 6 | 28,120 | Todd Ritchie | Greg Maddux | Greg Maddux | Todd Ritchie | | 170 | 243 | -73 |
| 2001-05-26 | @ ATL | 47 | L 3-9 | 15-32 | 6 | 40,788 | Don Wengert | John Burkett | John Burkett | Don Wengert | | 173 | 252 | -79 |
| 2001-05-27 | @ ATL | 48 | W 6-3 | 16-32 | 6 | 35,728 | Bronson Arroyo | Tom Glavine | Bronson Arroyo | Tom Glavine | Mike Williams | 179 | 255 | -76 |
| 2001-05-28 | vs FLO | 49 | W 8-5 | 17-32 | 6 | 26,512 | Omar Olivares | Chuck Smith | Jose Silva | Dan Miceli | Mike Williams | 187 | 260 | -73 |
| 2001-05-29 | vs FLO | 50 | L 0-5 | 17-33 | 6 | 21,083 | Jimmy Anderson | A.J. Burnett | A.J. Burnett | Jimmy Anderson | | 187 | 265 | -78 |
| 2001-05-30 | vs FLO | 51 | L 7-9 | 17-34 | 6 | 24,343 | Jason Schmidt | Brad Penny | Antonio Alfonseca | Mike Williams | Braden Looper | 194 | 274 | -80 |
| 2001-06-01 | vs ATL | 52 | L 1-5 | 17-35 | 6 | 34,230 | Todd Ritchie | John Burkett | John Burkett | Todd Ritchie | | 195 | 279 | -84 |
| 2001-06-03 | vs ATL | 53 | L 7-11 | 17-37 | 6 | 0 | Omar Olivares | Tom Glavine | Tom Glavine | Omar Olivares | | 202 | 290 | -88 |
| 2001-06-03 | vs ATL | 54 | L 3-8 | 17-37 | 6 | 36,924 | Jimmy Anderson | John Smoltz | John Smoltz | Jimmy Anderson | | 205 | 298 | -93 |
| 2001-06-05 | @ FLO | 55 | W 5-2 | 18-37 | 6 | 10,138 | Jason Schmidt | Brad Penny | Jason Schmidt | Brad Penny | Mike Williams | 210 | 300 | -90 |
| 2001-06-06 | @ FLO | 56 | L 2-7 | 18-38 | 6 | 10,114 | Todd Ritchie | Ryan Dempster | Ryan Dempster | Todd Ritchie | | 212 | 307 | -95 |
| 2001-06-07 | @ FLO | 57 | L 3-5 | 18-39 | 6 | 14,516 | Joe Beimel | Matt Clement | Ricky Bones | Josias Manzanillo | Antonio Alfonseca | 215 | 312 | -97 |
| 2001-06-08 | @ MIN | 58 | L 6-8 | 18-40 | 6 | 29,587 | Omar Olivares | Eric Milton | Hector Carrasco | Omar Olivares | LaTroy Hawkins | 221 | 320 | -99 |
| 2001-06-09 | @ MIN | 59 | L 2-3 | 18-41 | 6 | 26,685 | Jimmy Anderson | Joe Mays | Joe Mays | Jimmy Anderson | LaTroy Hawkins | 223 | 323 | -100 |
| 2001-06-10 | @ MIN | 60 | W 11-8 | 19-41 | 6 | 24,400 | Jason Schmidt | J.C. Romero | Scott Sauerbeck | Travis Miller | Mike Williams | 234 | 331 | -97 |
| 2001-06-12 | @ DET | 61 | W 13-3 | 20-41 | 6 | 15,919 | Todd Ritchie | Dave Mlicki | Todd Ritchie | Dave Mlicki | | 247 | 334 | -87 |
| 2001-06-13 | @ DET | 62 | L 3-6 | 20-42 | 6 | 17,639 | Joe Beimel | Jeff Weaver | Jeff Weaver | Joe Beimel | Matt Anderson | 250 | 340 | -90 |
| 2001-06-14 | @ DET | 63 | L 4-6 | 20-43 | 6 | 17,305 | Bronson Arroyo | Steve Sparks | Steve Sparks | Bronson Arroyo | Matt Anderson | 254 | 346 | -92 |
| 2001-06-15 | vs CLE | 64 | W 6-3 | 21-43 | 6 | 36,235 | Jimmy Anderson | Dave Burba | Jimmy Anderson | Dave Burba | Mike Williams | 260 | 349 | -89 |
| 2001-06-16 | vs CLE | 65 | W 6-4 | 22-43 | 6 | 37,056 | Jason Schmidt | Jaret Wright | Jason Schmidt | Jaret Wright | Mike Williams | 266 | 353 | -87 |
| 2001-06-17 | vs CLE | 66 | W 1-0 | 23-43 | 6 | 36,694 | Todd Ritchie | CC Sabathia | Todd Ritchie | Steve Karsay | | 267 | 353 | -86 |
| 2001-06-19 | vs PHI | 67 | W 8-5 | 24-43 | 6 | 33,713 | Joe Beimel | Bruce Chen | Joe Beimel | Bruce Chen | Scott Sauerbeck | 275 | 358 | -83 |
| 2001-06-20 | vs PHI | 68 | L 5-9 | 24-44 | 6 | 28,145 | Bronson Arroyo | Omar Daal | Omar Daal | Bronson Arroyo | | 280 | 367 | -87 |
| 2001-06-21 | vs PHI | 69 | L 3-6 | 24-45 | 6 | 29,560 | Jimmy Anderson | Robert Person | Robert Person | Jimmy Anderson | Jose Mesa | 283 | 373 | -90 |
| 2001-06-22 | vs MON | 70 | L 5-11 | 24-46 | 6 | 33,439 | Jason Schmidt | Tony Armas | Tony Armas | Jason Schmidt | | 288 | 384 | -96 |
| 2001-06-23 | vs MON | 71 | W 7-4 | 25-46 | 6 | 38,169 | Todd Ritchie | Masato Yoshii | Todd Ritchie | Masato Yoshii | Mike Williams | 295 | 388 | -93 |
| 2001-06-24 | vs MON | 72 | L 4-11 | 25-47 | 6 | 36,826 | Joe Beimel | Troy Mattes | Troy Mattes | Joe Beimel | | 299 | 399 | -100 |
| 2001-06-25 | vs MIL | 73 | W 6-4 | 26-47 | 6 | 22,470 | David Williams | Allen Levrault | David Williams | Allen Levrault | Mike Williams | 305 | 403 | -98 |
| 2001-06-26 | vs MIL | 74 | W 7-6 | 27-47 | 6 | 24,120 | Jimmy Anderson | Paul Rigdon | Omar Olivares | Ray King | | 312 | 409 | -97 |
| 2001-06-27 | vs MIL | 75 | W 6-2 | 28-47 | 6 | 25,756 | Jason Schmidt | Jimmy Haynes | Jason Schmidt | Jimmy Haynes | | 318 | 411 | -93 |
| 2001-06-28 | vs MIL | 76 | W 1-0 | 29-47 | 6 | 36,390 | Todd Ritchie | Jamey Wright | Todd Ritchie | Jamey Wright | Mike Williams | 319 | 411 | -92 |
| 2001-06-29 | @ MON | 77 | L 3-12 | 29-48 | 6 | 6,504 | Joe Beimel | Troy Mattes | Troy Mattes | Joe Beimel | | 322 | 423 | -101 |
| 2001-06-30 | @ MON | 78 | L 6-7 | 29-49 | 6 | 8,711 | David Williams | Javier Vazquez | Graeme Lloyd | Mike Williams | | 328 | 430 | -102 |
| 2001-07-01 | @ MON | 79 | L 3-9 | 29-50 | 6 | 6,631 | Jimmy Anderson | Mike Thurman | Mike Thurman | Jimmy Anderson | | 331 | 439 | -108 |
| 2001-07-02 | @ CIN | 80 | W 10-5 | 30-50 | 6 | 22,397 | Jason Schmidt | Lance Davis | Jason Schmidt | Lance Davis | | 341 | 444 | -103 |
| 2001-07-03 | @ CIN | 81 | W 3-2 | 31-50 | 6 | 21,724 | Todd Ritchie | Elmer Dessens | Todd Ritchie | Elmer Dessens | Mike Williams | 344 | 446 | -102 |
| 2001-07-04 | @ CIN | 82 | W 14-3 | 32-50 | 5 | 17,972 | Joe Beimel | Brian Reith | Joe Beimel | Brian Reith | | 358 | 449 | -91 |
| 2001-07-05 | @ CIN | 83 | L 1-7 | 32-51 | 6 | 24,128 | David Williams | Jose Acevedo | Jose Acevedo | David Williams | | 359 | 456 | -97 |
| 2001-07-06 | @ CHA | 84 | W 10-6 | 33-51 | 5 | 19,554 | Jimmy Anderson | Rocky Biddle | Josias Manzanillo | Bob Howry | | 369 | 462 | -93 |
| 2001-07-07 | @ CHA | 85 | L 1-4 | 33-52 | 5 | 25,113 | Jason Schmidt | Kip Wells | Kip Wells | Jason Schmidt | Keith Foulke | 370 | 466 | -96 |
| 2001-07-08 | @ CHA | 86 | L 2-9 | 33-53 | 5 | 22,105 | Todd Ritchie | Sean Lowe | Sean Lowe | Todd Ritchie | | 372 | 475 | -103 |
| 2001-07-12 | vs KCA | 87 | W 2-0 | 34-53 | 5 | 26,393 | Jimmy Anderson | Jeff Suppan | Jimmy Anderson | Jeff Suppan | Mike Williams | 374 | 475 | -101 |
| 2001-07-13 | vs KCA | 88 | W 1-0 | 35-53 | 5 | 35,325 | Todd Ritchie | Chad Durbin | Todd Ritchie | Jason Grimsley | | 375 | 475 | -100 |
| 2001-07-14 | vs KCA | 89 | L 4-7 | 35-54 | 5 | 37,789 | David Williams | Kris Wilson | Kris Wilson | David Williams | Roberto Hernandez | 379 | 482 | -103 |
| 2001-07-15 | vs LAN | 90 | L 2-4 | 35-55 | 5 | 38,152 | Jason Schmidt | Kevin Brown | Kevin Brown | Jason Schmidt | Jeff Shaw | 381 | 486 | -105 |
| 2001-07-16 | vs LAN | 91 | L 4-6 | 35-56 | 5 | 26,145 | Joe Beimel | Eric Gagne | Eric Gagne | Joe Beimel | Jeff Shaw | 385 | 492 | -107 |
| 2001-07-17 | vs LAN | 92 | L 1-4 | 35-57 | 5 | 30,150 | Jimmy Anderson | Terry Adams | Terry Adams | Jimmy Anderson | Matt Herges | 386 | 496 | -110 |
| 2001-07-18 | vs CHN | 93 | L 5-6 | 35-58 | 5 | 31,919 | Todd Ritchie | Kerry Wood | Jeff Fassero | Mike Williams | Tom Gordon | 391 | 502 | -111 |
| 2001-07-19 | vs CHN | 94 | W 3-2 | 36-58 | 5 | 34,921 | David Williams | Julian Tavarez | Omar Olivares | Courtney Duncan | Mike Williams | 394 | 504 | -110 |
| 2001-07-20 | @ SLN | 95 | W 4-1 | 37-58 | 5 | 35,215 | Jason Schmidt | Dustin Hermanson | Jason Schmidt | Dustin Hermanson | Josias Manzanillo | 398 | 505 | -107 |
| 2001-07-21 | @ SLN | 96 | L 2-9 | 37-59 | 5 | 44,930 | Joe Beimel | Bud Smith | Bud Smith | Joe Beimel | | 400 | 514 | -114 |
| 2001-07-22 | @ SLN | 97 | W 2-0 | 38-59 | 5 | 33,546 | Jimmy Anderson | Darryl Kile | Jimmy Anderson | Mike Timlin | Mike Williams | 402 | 514 | -112 |
| 2001-07-24 | @ CHN | 98 | L 2-10 | 38-60 | 5 | 40,269 | Todd Ritchie | Julian Tavarez | Julian Tavarez | Todd Ritchie | | 404 | 524 | -120 |
| 2001-07-25 | @ CHN | 99 | L 5-6 | 38-61 | 5 | 38,508 | David Williams | Jon Lieber | Jon Lieber | David Williams | | 409 | 530 | -121 |
| 2001-07-26 | vs HOU | 100 | L 2-3 | 38-62 | 5 | 30,245 | Jason Schmidt | Dave Mlicki | Dave Mlicki | Jason Schmidt | Billy Wagner | 411 | 533 | -122 |
| 2001-07-27 | vs HOU | 101 | W 3-2 | 39-62 | 5 | 38,463 | Joe Beimel | Shane Reynolds | Joe Beimel | Shane Reynolds | Mike Williams | 414 | 535 | -121 |
| 2001-07-28 | vs HOU | 102 | W 9-8 | 40-63 | 6 | 32,977 | Bronson Arroyo | Roy Oswalt | Omar Olivares | Billy Wagner | | 423 | 543 | -120 |
| 2001-07-28 | vs HOU | 103 | L 3-12 | 40-63 | 6 | 38,295 | Jimmy Anderson | Tony McKnight | Tony McKnight | Jimmy Anderson | | 426 | 555 | -129 |
| 2001-07-29 | vs HOU | 104 | W 4-1 | 41-63 | 6 | 37,166 | Todd Ritchie | Wade Miller | Todd Ritchie | Wade Miller | Mike Williams | 430 | 556 | -126 |
| 2001-07-31 | @ SFN | 105 | L 7-8 | 41-64 | 6 | 41,529 | David Williams | Livan Hernandez | Wayne Gomes | Marc Wilkins | | 437 | 564 | -127 |
| 2001-08-01 | @ SFN | 106 | L 1-3 | 41-65 | 6 | 41,251 | Joe Beimel | Jason Schmidt | Jason Schmidt | Joe Beimel | Robb Nen | 438 | 567 | -129 |
| 2001-08-02 | @ SFN | 107 | L 0-3 | 41-66 | 6 | 41,726 | Tony McKnight | Kirk Rueter | Kirk Rueter | Tony McKnight | Robb Nen | 438 | 570 | -132 |
| 2001-08-03 | @ COL | 108 | L 7-12 | 41-67 | 6 | 38,836 | Jimmy Anderson | Mike Hampton | Mike Hampton | Jimmy Anderson | | 445 | 582 | -137 |
| 2001-08-04 | @ COL | 109 | W 6-3 | 42-67 | 6 | 44,294 | Todd Ritchie | Shawn Chacon | Todd Ritchie | Shawn Chacon | | 451 | 585 | -134 |
| 2001-08-05 | @ COL | 110 | W 5-4 | 43-67 | 6 | 36,570 | David Williams | Brian Bohanon | Mike Lincoln | Brian Bohanon | Mike Fetters | 456 | 589 | -133 |
| 2001-08-07 | vs LAN | 111 | L 1-2 | 43-68 | 6 | 28,873 | Tony McKnight | Terry Adams | Terry Adams | Tony McKnight | Jeff Shaw | 457 | 591 | -134 |
| 2001-08-08 | vs LAN | 112 | L 4-9 | 43-69 | 6 | 29,528 | Jimmy Anderson | Luke Prokopec | Giovanni Carrara | Jimmy Anderson | | 461 | 600 | -139 |
| 2001-08-09 | vs LAN | 113 | W 8-5 | 44-69 | 6 | 29,841 | Todd Ritchie | Chan Ho Park | Todd Ritchie | Chan Ho Park | Mike Fetters | 469 | 605 | -136 |
| 2001-08-10 | vs SDN | 114 | L 2-3 | 44-70 | 6 | 36,588 | David Williams | Brian Tollberg | Brian Tollberg | David Williams | Trevor Hoffman | 471 | 608 | -137 |
| 2001-08-11 | vs SDN | 115 | L 2-6 | 44-71 | 6 | 39,388 | Joe Beimel | Brian Lawrence | Brian Lawrence | Joe Beimel | | 473 | 614 | -141 |
| 2001-08-12 | vs SDN | 116 | W 7-6 | 45-71 | 6 | 37,150 | Tony McKnight | Bobby Jones | Josias Manzanillo | Rodney Myers | | 480 | 620 | -140 |
| 2001-08-13 | @ ARI | 117 | L 0-3 | 45-72 | 6 | 32,386 | Jimmy Anderson | Randy Johnson | Randy Johnson | Jimmy Anderson | | 480 | 623 | -143 |
| 2001-08-14 | @ ARI | 118 | L 3-4 | 45-73 | 6 | 31,006 | Todd Ritchie | Brian Anderson | Miguel Batista | Damaso Marte | | 483 | 627 | -144 |
| 2001-08-15 | @ ARI | 119 | L 2-5 | 45-74 | 6 | 28,703 | David Williams | Curt Schilling | Curt Schilling | David Williams | | 485 | 632 | -147 |
| 2001-08-16 | @ HOU | 120 | L 3-4 | 45-75 | 6 | 26,518 | Joe Beimel | Wade Miller | Wade Miller | Joe Beimel | Billy Wagner | 488 | 636 | -148 |
| 2001-08-17 | @ HOU | 121 | L 5-6 | 45-76 | 6 | 37,363 | Tony McKnight | Dave Mlicki | Dave Mlicki | Tony McKnight | Billy Wagner | 493 | 642 | -149 |
| 2001-08-18 | @ HOU | 122 | L 0-3 | 45-77 | 6 | 41,955 | Jimmy Anderson | Carlos Hernandez | Carlos Hernandez | Jimmy Anderson | Octavio Dotel | 493 | 645 | -152 |
| 2001-08-19 | @ HOU | 123 | L 2-12 | 45-78 | 6 | 35,915 | Todd Ritchie | Roy Oswalt | Roy Oswalt | Todd Ritchie | | 495 | 657 | -162 |
| 2001-08-21 | vs ARI | 124 | W 4-2 | 46-78 | 6 | 35,131 | David Williams | Curt Schilling | Omar Olivares | Curt Schilling | Mike Fetters | 499 | 659 | -160 |
| 2001-08-22 | vs ARI | 125 | L 0-6 | 46-79 | 6 | 26,531 | Joe Beimel | Albie Lopez | Albie Lopez | Joe Beimel | | 499 | 665 | -166 |
| 2001-08-23 | vs ARI | 126 | W 5-1 | 47-79 | 6 | 30,794 | Tony McKnight | Randy Johnson | Tony McKnight | Randy Johnson | Mike Fetters | 504 | 666 | -162 |
| 2001-08-24 | vs HOU | 127 | L 1-5 | 47-80 | 6 | 37,324 | Jimmy Anderson | Roy Oswalt | Roy Oswalt | Jimmy Anderson | | 505 | 671 | -166 |
| 2001-08-25 | vs HOU | 128 | W 8-2 | 48-80 | 6 | 37,665 | Todd Ritchie | Dave Mlicki | Todd Ritchie | Dave Mlicki | | 513 | 673 | -160 |
| 2001-08-26 | vs HOU | 129 | L 1-3 | 48-81 | 6 | 34,850 | David Williams | Ron Villone | Ron Villone | David Williams | Billy Wagner | 514 | 676 | -162 |
| 2001-08-27 | @ MIL | 130 | L 5-12 | 48-82 | 6 | 26,289 | Joe Beimel | Rocky Coppinger | Rocky Coppinger | Joe Beimel | Mike Buddie | 519 | 688 | -169 |
| 2001-08-28 | @ MIL | 131 | W 6-5 | 49-82 | 6 | 23,579 | Tony McKnight | Mac Suzuki | Scott Sauerbeck | Curt Leskanic | Mike Fetters | 525 | 693 | -168 |
| 2001-08-29 | @ MIL | 132 | L 8-9 | 49-83 | 6 | 24,551 | Jimmy Anderson | Allen Levrault | Allen Levrault | Jimmy Anderson | Chad Fox | 533 | 702 | -169 |
| 2001-08-31 | @ CIN | 133 | L 3-11 | 49-84 | 6 | 19,090 | Todd Ritchie | Chris Reitsma | Chris Reitsma | Todd Ritchie | | 536 | 713 | -177 |
| 2001-09-01 | @ CIN | 134 | W 7-0 | 50-84 | 6 | 24,308 | David Williams | Jose Acevedo | David Williams | Jose Acevedo | | 543 | 713 | -170 |
| 2001-09-02 | @ CIN | 135 | L 6-8 | 50-85 | 6 | 21,881 | Tony McKnight | Lance Davis | Scott Sullivan | Mike Lincoln | Danny Graves | 549 | 721 | -172 |
| 2001-09-03 | vs MIL | 136 | L 7-12 | 51-86 | 6 | 0 | Ryan Vogelsong | Jeff D'Amico | Mark Leiter | Ryan Vogelsong | | 556 | 733 | -177 |
| 2001-09-03 | vs MIL | 137 | W 3-2 | 51-86 | 6 | 29,003 | Jimmy Anderson | Ruben Quevedo | Mike Fetters | Chad Fox | | 559 | 735 | -176 |
| 2001-09-04 | vs MIL | 138 | W 5-2 | 52-86 | 6 | 17,293 | Bronson Arroyo | Allen Levrault | Bronson Arroyo | Allen Levrault | Mike Fetters | 564 | 737 | -173 |
| 2001-09-05 | vs MIL | 139 | W 5-1 | 53-86 | 6 | 18,866 | Todd Ritchie | Jamey Wright | Todd Ritchie | Jamey Wright | | 569 | 738 | -169 |
| 2001-09-06 | vs CIN | 140 | L 6-8 | 53-87 | 6 | 20,683 | David Williams | Jose Acevedo | Jim Brower | Rich Loiselle | Danny Graves | 575 | 746 | -171 |
| 2001-09-07 | vs CIN | 141 | W 3-1 | 54-87 | 6 | 33,800 | Tony McKnight | Lance Davis | Tony McKnight | Lance Davis | Omar Olivares | 578 | 747 | -169 |
| 2001-09-08 | vs CIN | 142 | W 5-2 | 55-87 | 6 | 38,638 | Jimmy Anderson | Elmer Dessens | Jimmy Anderson | Elmer Dessens | | 583 | 749 | -166 |
| 2001-09-09 | vs CIN | 143 | L 3-5 | 55-88 | 6 | 33,214 | Ryan Vogelsong | Dennys Reyes | Dennys Reyes | Ryan Vogelsong | Danny Graves | 586 | 754 | -168 |
| 2001-09-17 | vs NYN | 144 | L 1-4 | 55-89 | 6 | 25,902 | Todd Ritchie | Al Leiter | John Franco | Mike Fetters | Armando Benitez | 587 | 758 | -171 |
| 2001-09-18 | vs NYN | 145 | L 5-7 | 55-90 | 6 | 19,285 | David Williams | Kevin Appier | Jerrod Riggan | Omar Olivares | Armando Benitez | 592 | 765 | -173 |
| 2001-09-19 | vs NYN | 146 | L 2-9 | 55-91 | 6 | 20,371 | Tony McKnight | Glendon Rusch | Dicky Gonzalez | Tony McKnight | | 594 | 774 | -180 |
| 2001-09-20 | vs SLN | 147 | L 1-9 | 55-92 | 6 | 21,678 | Jimmy Anderson | Woody Williams | Woody Williams | Jimmy Anderson | | 595 | 783 | -188 |
| 2001-09-21 | vs SLN | 148 | L 5-9 | 55-93 | 6 | 36,209 | Bronson Arroyo | Darryl Kile | Luther Hackman | Omar Olivares | | 600 | 792 | -192 |
| 2001-09-22 | vs SLN | 149 | L 1-4 | 55-94 | 6 | 37,539 | Todd Ritchie | Bud Smith | Bud Smith | Todd Ritchie | Gene Stechschulte | 601 | 796 | -195 |
| 2001-09-23 | vs SLN | 150 | W 2-1 | 56-94 | 6 | 33,633 | David Williams | Dustin Hermanson | David Williams | Dustin Hermanson | Josias Manzanillo | 603 | 797 | -194 |
| 2001-09-24 | vs CHN | 151 | W 7-6 | 57-94 | 6 | 18,908 | Tony McKnight | Kerry Wood | Mike Lincoln | Scott Chiasson | Rich Loiselle | 610 | 803 | -193 |
| 2001-09-25 | vs CHN | 152 | W 13-1 | 58-94 | 6 | 18,581 | Jimmy Anderson | Jason Bere | Jimmy Anderson | Jason Bere | | 623 | 804 | -181 |
| 2001-09-26 | vs CHN | 153 | L 4-8 | 58-95 | 6 | 25,564 | Bronson Arroyo | Juan Cruz | Juan Cruz | Bronson Arroyo | | 627 | 812 | -185 |
| 2001-09-28 | @ SLN | 154 | L 3-14 | 58-96 | 6 | 33,218 | Todd Ritchie | Dustin Hermanson | Dustin Hermanson | Todd Ritchie | | 630 | 826 | -196 |
| 2001-09-29 | @ SLN | 155 | L 0-2 | 58-97 | 6 | 39,782 | David Williams | Matt Morris | Matt Morris | David Williams | Gene Stechschulte | 630 | 828 | -198 |
| 2001-09-30 | @ SLN | 156 | L 3-7 | 58-98 | 6 | 42,442 | Tony McKnight | Woody Williams | Woody Williams | Tony McKnight | | 633 | 835 | -202 |
| 2001-10-01 | @ NYN | 157 | W 5-1 | 59-98 | 6 | 6,315 | Jimmy Anderson | Glendon Rusch | Jimmy Anderson | Glendon Rusch | Scott Sauerbeck | 638 | 836 | -198 |
| 2001-10-02 | @ NYN | 158 | W 10-1 | 60-98 | 6 | 8,058 | Bronson Arroyo | Bruce Chen | Bronson Arroyo | Bruce Chen | | 648 | 837 | -189 |
| 2001-10-03 | @ NYN | 159 | L 0-3 | 60-99 | 6 | 6,627 | Todd Ritchie | Steve Trachsel | Steve Trachsel | Todd Ritchie | | 648 | 840 | -192 |
| 2001-10-05 | @ CHN | 160 | W 3-2 | 61-99 | 6 | 24,786 | David Williams | Jason Bere | Joe Beimel | Jason Bere | Mike Fetters | 651 | 842 | -191 |
| 2001-10-06 | @ CHN | 161 | L 2-13 | 61-100 | 6 | 35,020 | Tony McKnight | Julian Tavarez | Julian Tavarez | Tony McKnight | | 653 | 855 | -202 |
| 2001-10-07 | @ CHN | 162 | W 4-3 | 62-100 | 6 | 35,083 | Jimmy Anderson | Juan Cruz | Joe Beimel | Carlos Zambrano | Mike Fetters | 657 | 858 | -201 |