| 2001-04-02 | @ SEA | 1 | L 4-5 | 0-1 | 3 | 45,911 | Tim Hudson | Freddy Garcia | Arthur Rhodes | Jim Mecir | Kazuhiro Sasaki | 4 | 5 | -1 |
| 2001-04-03 | @ SEA | 2 | W 5-1 | 1-1 | 1 | 27,212 | Barry Zito | John Halama | Barry Zito | John Halama | | 9 | 6 | 3 |
| 2001-04-04 | @ SEA | 3 | L 2-10 | 1-2 | 3 | 31,382 | Gil Heredia | Aaron Sele | Aaron Sele | Gil Heredia | | 11 | 16 | -5 |
| 2001-04-06 | vs ANA | 4 | L 4-5 | 1-3 | 4 | 42,826 | Mark Mulder | Matt Wise | Matt Wise | Mark Mulder | Troy Percival | 15 | 21 | -6 |
| 2001-04-07 | vs ANA | 5 | W 4-2 | 2-3 | 3 | 21,398 | Tim Hudson | Steve Green | Tim Hudson | Al Levine | Jason Isringhausen | 19 | 23 | -4 |
| 2001-04-08 | vs ANA | 6 | L 4-6 | 2-4 | 4 | 26,211 | Barry Zito | Scott Schoeneweis | Scott Schoeneweis | Barry Zito | Troy Percival | 23 | 29 | -6 |
| 2001-04-10 | vs SEA | 7 | L 1-5 | 2-5 | 4 | 14,880 | Gil Heredia | John Halama | John Halama | Gil Heredia | Kazuhiro Sasaki | 24 | 34 | -10 |
| 2001-04-11 | vs SEA | 8 | L 0-3 | 2-6 | 4 | 16,652 | Mark Mulder | Aaron Sele | Aaron Sele | Jim Mecir | Kazuhiro Sasaki | 24 | 37 | -13 |
| 2001-04-12 | vs SEA | 9 | L 3-7 | 2-7 | 4 | 15,414 | Tim Hudson | Jamie Moyer | Jamie Moyer | Tim Hudson | | 27 | 44 | -17 |
| 2001-04-13 | vs TEX | 10 | L 1-13 | 2-8 | 4 | 19,255 | Cory Lidle | Doug Davis | Doug Davis | Cory Lidle | | 28 | 57 | -29 |
| 2001-04-14 | vs TEX | 11 | L 8-9 | 2-9 | 4 | 26,730 | Barry Zito | Kenny Rogers | Jeff Zimmerman | Jim Mecir | Tim Crabtree | 36 | 66 | -30 |
| 2001-04-15 | vs TEX | 12 | L 8-10 | 2-10 | 4 | 18,853 | Gil Heredia | Darren Oliver | Darren Oliver | Gil Heredia | Mike Venafro | 44 | 76 | -32 |
| 2001-04-16 | @ ANA | 13 | W 6-3 | 3-10 | 4 | 16,368 | Mark Mulder | Jarrod Washburn | Mark Mulder | Jarrod Washburn | Jason Isringhausen | 50 | 79 | -29 |
| 2001-04-17 | @ ANA | 14 | W 5-1 | 4-10 | 4 | 17,837 | Tim Hudson | Ramon Ortiz | Tim Hudson | Ramon Ortiz | | 55 | 80 | -25 |
| 2001-04-18 | @ ANA | 15 | L 2-3 | 4-11 | 4 | 17,962 | Cory Lidle | Scott Schoeneweis | Troy Percival | Jim Mecir | | 57 | 83 | -26 |
| 2001-04-19 | @ TEX | 16 | W 9-5 | 5-11 | 4 | 33,311 | Barry Zito | Kenny Rogers | Barry Zito | Kenny Rogers | T.J. Mathews | 66 | 88 | -22 |
| 2001-04-20 | @ TEX | 17 | L 6-9 | 5-12 | 4 | 39,041 | Gil Heredia | Darren Oliver | Darren Oliver | Gil Heredia | | 72 | 97 | -25 |
| 2001-04-21 | @ TEX | 18 | W 7-6 | 6-12 | 4 | 45,174 | Mark Mulder | Ryan Glynn | Mark Mulder | Pat Mahomes | Jason Isringhausen | 79 | 103 | -24 |
| 2001-04-22 | @ TEX | 19 | L 2-11 | 6-13 | 4 | 32,527 | Tim Hudson | Rick Helling | Rick Helling | Tim Hudson | | 81 | 114 | -33 |
| 2001-04-24 | @ CHA | 20 | W 6-4 | 7-13 | 4 | 12,441 | Barry Zito | Mark Buehrle | Barry Zito | Mark Buehrle | Jason Isringhausen | 87 | 118 | -31 |
| 2001-04-25 | @ CHA | 21 | L 1-2 | 7-14 | 4 | 12,941 | Cory Lidle | David Wells | Keith Foulke | Chad Bradford | | 88 | 120 | -32 |
| 2001-04-26 | @ CHA | 22 | W 16-6 | 8-14 | 4 | 12,963 | Gil Heredia | Jim Parque | Gil Heredia | Jim Parque | | 104 | 126 | -22 |
| 2001-04-27 | @ NYA | 23 | L 2-3 | 8-15 | 4 | 35,170 | Mark Mulder | Orlando Hernandez | Randy Choate | Mark Mulder | Mariano Rivera | 106 | 129 | -23 |
| 2001-04-28 | @ NYA | 24 | L 6-7 | 8-16 | 4 | 38,422 | Tim Hudson | Ted Lilly | Ted Lilly | Tim Hudson | Mariano Rivera | 112 | 136 | -24 |
| 2001-04-29 | @ NYA | 25 | L 1-3 | 8-17 | 4 | 50,572 | Barry Zito | Roger Clemens | Roger Clemens | Barry Zito | Mariano Rivera | 113 | 139 | -26 |
| 2001-05-01 | vs TOR | 26 | L 4-5 | 8-18 | 4 | 10,935 | Cory Lidle | Chris Carpenter | Paul Quantrill | Jason Isringhausen | Billy Koch | 117 | 144 | -27 |
| 2001-05-02 | vs TOR | 27 | W 6-0 | 9-18 | 4 | 14,048 | Mark Mulder | Esteban Loaiza | Mark Mulder | Esteban Loaiza | | 123 | 144 | -21 |
| 2001-05-03 | vs TOR | 28 | W 3-2 | 10-18 | 4 | 10,586 | Tim Hudson | Chris Michalak | Chad Bradford | Pedro Borbon | | 126 | 146 | -20 |
| 2001-05-04 | vs BOS | 29 | W 7-3 | 11-18 | 4 | 20,631 | Gil Heredia | Tomo Ohka | Gil Heredia | Derek Lowe | Jeff Tam | 133 | 149 | -16 |
| 2001-05-05 | vs BOS | 30 | L 1-7 | 11-19 | 4 | 29,248 | Barry Zito | Paxton Crawford | Paxton Crawford | Barry Zito | | 134 | 156 | -22 |
| 2001-05-06 | vs BOS | 31 | L 4-5 | 11-20 | 4 | 40,186 | Cory Lidle | Pedro Martinez | Pedro Martinez | Cory Lidle | Rod Beck | 138 | 161 | -23 |
| 2001-05-08 | @ TOR | 32 | W 8-5 | 12-20 | 3 | 16,479 | Mark Mulder | Esteban Loaiza | Mark Mulder | Esteban Loaiza | Jim Mecir | 146 | 166 | -20 |
| 2001-05-09 | @ TOR | 33 | W 8-5 | 13-20 | 3 | 16,241 | Tim Hudson | Chris Michalak | Tim Hudson | Chris Michalak | Jason Isringhausen | 154 | 171 | -17 |
| 2001-05-10 | @ TOR | 34 | W 14-8 | 14-20 | 3 | 16,130 | Barry Zito | Steve Parris | Mark Guthrie | Lance Painter | | 168 | 179 | -11 |
| 2001-05-11 | @ BOS | 35 | W 7-6 | 15-20 | 3 | 32,718 | Cory Lidle | Paxton Crawford | Jason Isringhausen | Rod Beck | Jeff Tam | 175 | 185 | -10 |
| 2001-05-12 | @ BOS | 36 | L 3-9 | 15-21 | 3 | 32,686 | Gil Heredia | Pedro Martinez | Pedro Martinez | Gil Heredia | | 178 | 194 | -16 |
| 2001-05-13 | @ BOS | 37 | L 4-5 | 15-22 | 3 | 31,926 | Mark Mulder | Hideo Nomo | Derek Lowe | Jeff Tam | | 182 | 199 | -17 |
| 2001-05-15 | vs NYA | 38 | W 3-2 | 16-22 | 3 | 24,351 | Tim Hudson | Roger Clemens | Mark Guthrie | Ramiro Mendoza | | 185 | 201 | -16 |
| 2001-05-16 | vs NYA | 39 | W 4-3 | 17-22 | 3 | 43,932 | Barry Zito | Andy Pettitte | Mark Guthrie | Brian Boehringer | | 189 | 204 | -15 |
| 2001-05-17 | vs NYA | 40 | W 8-3 | 18-22 | 3 | 31,073 | Cory Lidle | Mike Mussina | Chad Bradford | Mike Mussina | | 197 | 207 | -10 |
| 2001-05-18 | vs CHA | 41 | W 3-2 | 19-22 | 3 | 16,823 | Gil Heredia | Kip Wells | Gil Heredia | Kip Wells | Jason Isringhausen | 200 | 209 | -9 |
| 2001-05-19 | vs CHA | 42 | W 4-3 | 20-22 | 2 | 30,820 | Mark Mulder | James Baldwin | Mark Mulder | James Baldwin | Jason Isringhausen | 204 | 212 | -8 |
| 2001-05-20 | vs CHA | 43 | W 6-2 | 21-22 | 2 | 39,249 | Tim Hudson | Mark Buehrle | Tim Hudson | Bob Howry | | 210 | 214 | -4 |
| 2001-05-22 | @ KCA | 44 | W 4-1 | 22-22 | 2 | 15,233 | Barry Zito | Jeff Suppan | Jim Mecir | Jeff Suppan | Jason Isringhausen | 214 | 215 | -1 |
| 2001-05-23 | @ KCA | 45 | L 1-4 | 22-23 | 2 | 13,316 | Cory Lidle | Chad Durbin | Chad Durbin | Cory Lidle | Roberto Hernandez | 215 | 219 | -4 |
| 2001-05-25 | @ MIN | 46 | W 4-2 | 23-23 | 2 | 20,866 | Mark Mulder | Joe Mays | Mark Mulder | Joe Mays | Jason Isringhausen | 219 | 221 | -2 |
| 2001-05-26 | @ MIN | 47 | W 5-4 | 24-24 | 2 | 0 | Tim Hudson | J.C. Romero | Jim Mecir | Bob Wells | Mark Guthrie | 224 | 225 | -1 |
| 2001-05-26 | @ MIN | 48 | L 6-7 | 24-24 | 2 | 38,047 | Gil Heredia | Brad Thomas | Eddie Guardado | Mark Guthrie | | 230 | 232 | -2 |
| 2001-05-27 | @ MIN | 49 | L 3-9 | 24-25 | 2 | 29,276 | Barry Zito | Brad Radke | Eddie Guardado | Barry Zito | | 233 | 241 | -8 |
| 2001-05-29 | vs TBA | 50 | L 1-5 | 24-26 | 2 | 11,334 | Cory Lidle | Tanyon Sturtze | Tanyon Sturtze | Cory Lidle | Travis Phelps | 234 | 246 | -12 |
| 2001-05-30 | vs TBA | 51 | W 15-2 | 25-26 | 2 | 17,901 | Mark Mulder | Albie Lopez | Mark Mulder | Albie Lopez | | 249 | 248 | 1 |
| 2001-05-31 | vs TBA | 52 | W 10-1 | 26-26 | 2 | 16,308 | Tim Hudson | Paul Wilson | Tim Hudson | Paul Wilson | | 259 | 249 | 10 |
| 2001-06-01 | vs BAL | 53 | L 4-8 | 26-27 | 2 | 30,168 | Gil Heredia | Sidney Ponson | Sidney Ponson | Jim Mecir | | 263 | 257 | 6 |
| 2001-06-02 | vs BAL | 54 | L 0-7 | 26-28 | 3 | 23,726 | Barry Zito | Josh Towers | Josh Towers | Barry Zito | | 263 | 264 | -1 |
| 2001-06-03 | vs BAL | 55 | W 5-1 | 27-28 | 3 | 18,977 | Cory Lidle | Willis Roberts | Cory Lidle | Willis Roberts | | 268 | 265 | 3 |
| 2001-06-05 | @ ANA | 56 | L 3-7 | 27-29 | 3 | 16,166 | Mark Mulder | Jarrod Washburn | Jarrod Washburn | Mark Mulder | | 271 | 272 | -1 |
| 2001-06-06 | @ ANA | 57 | W 4-1 | 28-29 | 3 | 15,356 | Tim Hudson | Pat Rapp | Tim Hudson | Pat Rapp | Jason Isringhausen | 275 | 273 | 2 |
| 2001-06-07 | @ ANA | 58 | L 4-6 | 28-30 | 3 | 15,859 | Barry Zito | Scott Schoeneweis | Scott Schoeneweis | Barry Zito | Troy Percival | 279 | 279 | 0 |
| 2001-06-08 | vs SFN | 59 | W 4-2 | 29-30 | 3 | 41,904 | Gil Heredia | Mark Gardner | Gil Heredia | Mark Gardner | Jason Isringhausen | 283 | 281 | 2 |
| 2001-06-09 | vs SFN | 60 | L 3-4 | 29-31 | 3 | 50,273 | Cory Lidle | Shawn Estes | Felix Rodriguez | T.J. Mathews | Robb Nen | 286 | 285 | 1 |
| 2001-06-10 | vs SFN | 61 | W 6-2 | 30-31 | 3 | 47,859 | Mark Mulder | Livan Hernandez | Mark Mulder | Livan Hernandez | Chad Bradford | 292 | 287 | 5 |
| 2001-06-12 | @ SDN | 62 | W 5-2 | 31-31 | 3 | 20,793 | Tim Hudson | Woody Williams | Tim Hudson | Woody Williams | Jason Isringhausen | 297 | 289 | 8 |
| 2001-06-13 | @ SDN | 63 | W 6-2 | 32-31 | 2 | 14,707 | Barry Zito | Adam Eaton | Mark Guthrie | Jose Nunez | Jeff Tam | 303 | 291 | 12 |
| 2001-06-14 | @ SDN | 64 | L 4-6 | 32-32 | 2 | 17,053 | Gil Heredia | Kevin Jarvis | Tom Davey | Jim Mecir | Trevor Hoffman | 307 | 297 | 10 |
| 2001-06-15 | @ SFN | 65 | L 1-3 | 32-33 | 2 | 40,849 | Mark Mulder | Shawn Estes | Shawn Estes | Mark Mulder | Robb Nen | 308 | 300 | 8 |
| 2001-06-16 | @ SFN | 66 | L 1-2 | 32-34 | 3 | 41,094 | Cory Lidle | Livan Hernandez | Livan Hernandez | Jeff Tam | Robb Nen | 309 | 302 | 7 |
| 2001-06-17 | @ SFN | 67 | L 0-3 | 32-35 | 3 | 41,506 | Tim Hudson | Kirk Rueter | Kirk Rueter | Tim Hudson | Robb Nen | 309 | 305 | 4 |
| 2001-06-18 | vs SEA | 68 | W 4-3 | 33-35 | 3 | 16,368 | Barry Zito | Jamie Moyer | Barry Zito | Norm Charlton | Jason Isringhausen | 313 | 308 | 5 |
| 2001-06-19 | vs SEA | 69 | L 7-8 | 33-36 | 3 | 17,542 | Gil Heredia | Paul Abbott | Arthur Rhodes | Jason Isringhausen | Kazuhiro Sasaki | 320 | 316 | 4 |
| 2001-06-20 | vs SEA | 70 | W 6-4 | 34-36 | 3 | 40,639 | Mark Mulder | Freddy Garcia | Mark Guthrie | Kazuhiro Sasaki | | 326 | 320 | 6 |
| 2001-06-21 | vs SEA | 71 | L 10-12 | 34-37 | 3 | 23,642 | Cory Lidle | John Halama | Jose Paniagua | Jeff Tam | Arthur Rhodes | 336 | 332 | 4 |
| 2001-06-22 | vs TEX | 72 | L 1-2 | 34-38 | 3 | 18,615 | Tim Hudson | Doug Davis | Doug Davis | Tim Hudson | Jeff Zimmerman | 337 | 334 | 3 |
| 2001-06-23 | vs TEX | 73 | W 5-4 | 35-38 | 3 | 26,324 | Barry Zito | Darren Oliver | Jason Isringhausen | Francisco Cordero | | 342 | 338 | 4 |
| 2001-06-24 | vs TEX | 74 | L 5-9 | 35-39 | 3 | 28,266 | Gil Heredia | Rob Bell | Rob Bell | Gil Heredia | Mike Venafro | 347 | 347 | 0 |
| 2001-06-26 | @ SEA | 75 | L 3-7 | 35-40 | 3 | 45,337 | Mark Mulder | Freddy Garcia | Freddy Garcia | Mark Mulder | | 350 | 354 | -4 |
| 2001-06-27 | @ SEA | 76 | W 6-3 | 36-40 | 3 | 45,104 | Tim Hudson | John Halama | Tim Hudson | John Halama | Jason Isringhausen | 356 | 357 | -1 |
| 2001-06-28 | @ SEA | 77 | W 6-3 | 37-40 | 3 | 45,399 | Barry Zito | Aaron Sele | Mark Guthrie | Brian Fuentes | Jason Isringhausen | 362 | 360 | 2 |
| 2001-06-29 | @ TEX | 78 | L 6-9 | 37-41 | 3 | 40,025 | Cory Lidle | Rob Bell | Pat Mahomes | Mike Magnante | Jeff Zimmerman | 368 | 369 | -1 |
| 2001-06-30 | @ TEX | 79 | W 15-4 | 38-41 | 3 | 42,553 | Erik Hiljus | Kenny Rogers | Erik Hiljus | Kenny Rogers | | 383 | 373 | 10 |
| 2001-07-01 | @ TEX | 80 | L 1-3 | 38-42 | 3 | 26,547 | Mark Mulder | Rick Helling | Mike Venafro | Mark Mulder | Jeff Zimmerman | 384 | 376 | 8 |
| 2001-07-02 | vs ANA | 81 | W 1-0 | 39-42 | 2 | 11,222 | Tim Hudson | Jarrod Washburn | Jeff Tam | Shigetoshi Hasegawa | | 385 | 376 | 9 |
| 2001-07-03 | vs ANA | 82 | W 5-2 | 40-42 | 2 | 51,838 | Barry Zito | Pat Rapp | Barry Zito | Pat Rapp | Jason Isringhausen | 390 | 378 | 12 |
| 2001-07-04 | vs ANA | 83 | W 2-0 | 41-42 | 2 | 29,045 | Cory Lidle | Scott Schoeneweis | Cory Lidle | Scott Schoeneweis | Jim Mecir | 392 | 378 | 14 |
| 2001-07-05 | vs ANA | 84 | L 2-5 | 41-43 | 2 | 12,719 | Gil Heredia | Ismael Valdez | Ismael Valdez | Gil Heredia | Troy Percival | 394 | 383 | 11 |
| 2001-07-06 | @ ARI | 85 | W 3-0 | 42-43 | 2 | 34,008 | Mark Mulder | Brian Anderson | Mark Mulder | Brian Anderson | | 397 | 383 | 14 |
| 2001-07-07 | @ ARI | 86 | W 5-1 | 43-43 | 2 | 36,978 | Tim Hudson | Miguel Batista | Tim Hudson | Miguel Batista | | 402 | 384 | 18 |
| 2001-07-08 | @ ARI | 87 | W 2-1 | 44-43 | 2 | 31,927 | Barry Zito | Curt Schilling | Barry Zito | Curt Schilling | Jason Isringhausen | 404 | 385 | 19 |
| 2001-07-12 | vs LAN | 88 | W 6-0 | 45-43 | 2 | 18,293 | Mark Mulder | Terry Adams | Mark Mulder | Terry Adams | | 410 | 385 | 25 |
| 2001-07-13 | vs LAN | 89 | W 11-7 | 46-43 | 2 | 28,627 | Tim Hudson | Chan Ho Park | Tim Hudson | Chan Ho Park | Jason Isringhausen | 421 | 392 | 29 |
| 2001-07-14 | vs LAN | 90 | L 3-5 | 46-44 | 2 | 35,163 | Barry Zito | Luke Prokopec | Alberto Reyes | Mark Guthrie | | 424 | 397 | 27 |
| 2001-07-15 | vs COL | 91 | W 6-3 | 47-44 | 2 | 24,327 | Cory Lidle | Brian Bohanon | Cory Lidle | Brian Bohanon | Luis Vizcaino | 430 | 400 | 30 |
| 2001-07-16 | vs COL | 92 | W 5-1 | 48-44 | 2 | 13,808 | Gil Heredia | Denny Neagle | Gil Heredia | Denny Neagle | | 435 | 401 | 34 |
| 2001-07-17 | vs COL | 93 | W 3-2 | 49-44 | 2 | 22,099 | Mark Mulder | Pedro Astacio | Mark Mulder | Pedro Astacio | Jason Isringhausen | 438 | 403 | 35 |
| 2001-07-18 | @ MIN | 94 | W 7-2 | 50-44 | 2 | 20,024 | Tim Hudson | Brad Radke | Tim Hudson | Brad Radke | | 445 | 405 | 40 |
| 2001-07-19 | @ MIN | 95 | L 10-12 | 50-45 | 2 | 19,605 | Barry Zito | Eric Milton | Eric Milton | Barry Zito | LaTroy Hawkins | 455 | 417 | 38 |
| 2001-07-20 | @ KCA | 96 | W 14-3 | 51-45 | 2 | 30,523 | Cory Lidle | Paul Byrd | Cory Lidle | Paul Byrd | | 469 | 420 | 49 |
| 2001-07-21 | @ KCA | 97 | W 10-1 | 52-45 | 2 | 25,830 | Gil Heredia | Dan Reichert | Gil Heredia | Dan Reichert | | 479 | 421 | 58 |
| 2001-07-22 | @ KCA | 98 | L 4-5 | 52-46 | 2 | 17,252 | Mark Mulder | Jeff Suppan | Roberto Hernandez | Jim Mecir | | 483 | 426 | 57 |
| 2001-07-23 | @ KCA | 99 | W 7-2 | 53-46 | 2 | 20,807 | Tim Hudson | Chad Durbin | Tim Hudson | Chad Durbin | | 490 | 428 | 62 |
| 2001-07-24 | vs MIN | 100 | W 7-6 | 54-46 | 2 | 13,407 | Barry Zito | Eric Milton | Jason Isringhausen | Travis Miller | | 497 | 434 | 63 |
| 2001-07-25 | vs MIN | 101 | L 1-3 | 54-47 | 2 | 31,426 | Cory Lidle | Joe Mays | Joe Mays | Cory Lidle | LaTroy Hawkins | 498 | 437 | 61 |
| 2001-07-26 | vs MIN | 102 | L 4-7 | 54-48 | 2 | 20,891 | Gil Heredia | Adam Johnson | Adam Johnson | Gil Heredia | | 502 | 444 | 58 |
| 2001-07-27 | vs KCA | 103 | W 5-0 | 55-48 | 2 | 14,413 | Mark Mulder | Jeff Suppan | Mark Mulder | Jeff Suppan | | 507 | 444 | 63 |
| 2001-07-28 | vs KCA | 104 | L 3-9 | 55-49 | 2 | 40,242 | Tim Hudson | Chad Durbin | Chad Durbin | Tim Hudson | | 510 | 453 | 57 |
| 2001-07-29 | vs KCA | 105 | W 6-4 | 56-49 | 2 | 19,384 | Barry Zito | Kris Wilson | Jason Isringhausen | Jason Grimsley | Jim Mecir | 516 | 457 | 59 |
| 2001-07-31 | @ CLE | 106 | W 11-2 | 57-49 | 2 | 38,830 | Cory Lidle | Jake Westbrook | Cory Lidle | Jake Westbrook | | 527 | 459 | 68 |
| 2001-08-01 | @ CLE | 107 | L 5-6 | 57-50 | 2 | 40,592 | Erik Hiljus | Charles Nagy | Danys Baez | Jim Mecir | Bob Wickman | 532 | 465 | 67 |
| 2001-08-02 | @ CLE | 108 | W 17-4 | 58-50 | 2 | 38,226 | Mark Mulder | CC Sabathia | Mark Mulder | CC Sabathia | | 549 | 469 | 80 |
| 2001-08-03 | @ DET | 109 | W 2-1 | 59-50 | 2 | 30,071 | Tim Hudson | Jeff Weaver | Tim Hudson | Jeff Weaver | | 551 | 470 | 81 |
| 2001-08-04 | @ DET | 110 | W 10-1 | 60-50 | 2 | 28,331 | Barry Zito | Steve Sparks | Barry Zito | Steve Sparks | | 561 | 471 | 90 |
| 2001-08-05 | @ DET | 111 | W 4-1 | 61-50 | 2 | 26,626 | Cory Lidle | Jose Lima | Cory Lidle | Jose Lima | Jason Isringhausen | 565 | 472 | 93 |
| 2001-08-06 | @ DET | 112 | W 6-3 | 62-50 | 2 | 21,830 | Erik Hiljus | Chris Holt | Luis Vizcaino | Danny Patterson | Jason Isringhausen | 571 | 475 | 96 |
| 2001-08-07 | vs BOS | 113 | W 5-2 | 63-50 | 2 | 26,650 | Mark Mulder | Bret Saberhagen | Mark Mulder | Bret Saberhagen | Jason Isringhausen | 576 | 477 | 99 |
| 2001-08-08 | vs BOS | 114 | W 6-1 | 64-50 | 2 | 50,863 | Tim Hudson | Frank Castillo | Tim Hudson | Frank Castillo | | 582 | 478 | 104 |
| 2001-08-09 | vs BOS | 115 | W 6-0 | 65-50 | 2 | 28,781 | Barry Zito | Tim Wakefield | Barry Zito | Tim Wakefield | | 588 | 478 | 110 |
| 2001-08-10 | vs NYA | 116 | W 8-1 | 66-50 | 2 | 38,728 | Cory Lidle | Ted Lilly | Cory Lidle | Ted Lilly | | 596 | 479 | 117 |
| 2001-08-11 | vs NYA | 117 | W 8-6 | 67-50 | 2 | 45,253 | Erik Hiljus | Sterling Hitchcock | Mike Magnante | Sterling Hitchcock | Jason Isringhausen | 604 | 485 | 119 |
| 2001-08-12 | vs NYA | 118 | W 4-2 | 68-50 | 2 | 47,725 | Mark Mulder | Mike Mussina | Mark Mulder | Mike Stanton | | 608 | 487 | 121 |
| 2001-08-14 | @ TOR | 119 | L 3-6 | 68-51 | 2 | 25,121 | Tim Hudson | Chris Carpenter | Billy Koch | Jason Isringhausen | | 611 | 493 | 118 |
| 2001-08-15 | @ TOR | 120 | L 2-5 | 68-52 | 2 | 23,135 | Barry Zito | Kelvim Escobar | Kelvim Escobar | Barry Zito | Billy Koch | 613 | 498 | 115 |
| 2001-08-16 | @ TOR | 121 | W 8-4 | 69-52 | 2 | 30,062 | Cory Lidle | Brandon Lyon | Cory Lidle | Brandon Lyon | | 621 | 502 | 119 |
| 2001-08-17 | @ CHA | 122 | W 9-2 | 70-52 | 2 | 33,834 | Erik Hiljus | Dan Wright | Erik Hiljus | Dan Wright | | 630 | 504 | 126 |
| 2001-08-18 | @ CHA | 123 | W 5-4 | 71-52 | 2 | 27,861 | Mark Mulder | Gary Glover | Gil Heredia | Bob Howry | Jason Isringhausen | 635 | 508 | 127 |
| 2001-08-19 | @ CHA | 124 | W 8-7 | 72-52 | 2 | 25,019 | Tim Hudson | Mark Buehrle | Mike Magnante | Rocky Biddle | Jason Isringhausen | 643 | 515 | 128 |
| 2001-08-20 | vs CLE | 125 | W 9-0 | 73-52 | 2 | 18,133 | Barry Zito | Chuck Finley | Barry Zito | Chuck Finley | | 652 | 515 | 137 |
| 2001-08-21 | vs CLE | 126 | L 1-2 | 73-53 | 2 | 19,343 | Cory Lidle | Steve Woodard | Steve Woodard | Cory Lidle | Bob Wickman | 653 | 517 | 136 |
| 2001-08-22 | vs CLE | 127 | L 4-5 | 73-54 | 2 | 40,992 | Erik Hiljus | Dave Burba | Bob Wickman | Luis Vizcaino | David Riske | 657 | 522 | 135 |
| 2001-08-23 | vs CLE | 128 | L 7-9 | 73-55 | 2 | 22,281 | Mark Mulder | CC Sabathia | Charles Nagy | Mark Mulder | Bob Wickman | 664 | 531 | 133 |
| 2001-08-24 | vs DET | 129 | L 4-8 | 73-56 | 2 | 41,646 | Tim Hudson | Nate Cornejo | Nate Cornejo | Tim Hudson | | 668 | 539 | 129 |
| 2001-08-25 | vs DET | 130 | W 6-1 | 74-56 | 2 | 24,236 | Barry Zito | Steve Sparks | Barry Zito | Steve Sparks | | 674 | 540 | 134 |
| 2001-08-26 | vs DET | 131 | W 7-6 | 75-56 | 2 | 27,915 | Cory Lidle | Jeff Weaver | Jeff Tam | Matt Perisho | Jason Isringhausen | 681 | 546 | 135 |
| 2001-08-28 | @ BAL | 132 | W 6-2 | 76-56 | 2 | 31,048 | Mark Mulder | Sidney Ponson | Mark Mulder | Sidney Ponson | | 687 | 548 | 139 |
| 2001-08-29 | @ BAL | 133 | W 4-1 | 77-56 | 2 | 31,628 | Tim Hudson | Josh Towers | Tim Hudson | Josh Towers | | 691 | 549 | 142 |
| 2001-08-30 | @ BAL | 134 | W 15-0 | 78-56 | 2 | 44,068 | Barry Zito | Jason Johnson | Barry Zito | Jason Johnson | | 706 | 549 | 157 |
| 2001-08-31 | @ TBA | 135 | W 9-5 | 79-56 | 2 | 11,230 | Cory Lidle | Bryan Rekar | Cory Lidle | Bryan Rekar | | 715 | 554 | 161 |
| 2001-09-01 | @ TBA | 136 | L 6-8 | 79-57 | 2 | 15,944 | Erik Hiljus | Nick Bierbrodt | Bobby Seay | Jeff Tam | Esteban Yan | 721 | 562 | 159 |
| 2001-09-02 | @ TBA | 137 | W 3-1 | 80-57 | 2 | 14,634 | Mark Mulder | Joe Kennedy | Mark Mulder | Doug Creek | | 724 | 563 | 161 |
| 2001-09-03 | vs BAL | 138 | W 4-2 | 81-57 | 2 | 28,665 | Tim Hudson | Josh Towers | Tim Hudson | Josh Towers | Jason Isringhausen | 728 | 565 | 163 |
| 2001-09-04 | vs BAL | 139 | W 5-2 | 82-57 | 2 | 16,123 | Barry Zito | Jason Johnson | Barry Zito | Jason Johnson | Jason Isringhausen | 733 | 567 | 166 |
| 2001-09-05 | vs BAL | 140 | W 12-6 | 83-57 | 2 | 30,922 | Cory Lidle | Calvin Maduro | Cory Lidle | Calvin Maduro | | 745 | 573 | 172 |
| 2001-09-07 | vs TBA | 141 | W 9-3 | 84-57 | 2 | 15,037 | Erik Hiljus | Bryan Rekar | Erik Hiljus | Bryan Rekar | | 754 | 576 | 178 |
| 2001-09-08 | vs TBA | 142 | W 10-4 | 85-57 | 2 | 32,548 | Mark Mulder | Nick Bierbrodt | Mark Mulder | Nick Bierbrodt | | 764 | 580 | 184 |
| 2001-09-09 | vs TBA | 143 | W 4-3 | 86-57 | 2 | 18,871 | Tim Hudson | Joe Kennedy | Luis Vizcaino | Jesus Colome | | 768 | 583 | 185 |
| 2001-09-10 | vs TEX | 144 | W 7-1 | 87-57 | 2 | 12,115 | Barry Zito | Aaron Myette | Barry Zito | Aaron Myette | | 775 | 584 | 191 |
| 2001-09-18 | @ TEX | 145 | W 6-5 | 88-57 | 2 | 21,517 | Mark Mulder | Rick Helling | Mark Mulder | Mike Venafro | Jason Isringhausen | 781 | 589 | 192 |
| 2001-09-19 | @ TEX | 146 | L 4-10 | 88-58 | 2 | 25,013 | Tim Hudson | Doug Davis | Doug Davis | Tim Hudson | Chris Michalak | 785 | 599 | 186 |
| 2001-09-20 | @ TEX | 147 | W 7-2 | 89-58 | 2 | 22,219 | Barry Zito | Darren Oliver | Barry Zito | Darren Oliver | | 792 | 601 | 191 |
| 2001-09-21 | vs SEA | 148 | W 5-1 | 90-58 | 2 | 30,387 | Cory Lidle | Paul Abbott | Cory Lidle | Paul Abbott | Jason Isringhausen | 797 | 602 | 195 |
| 2001-09-22 | vs SEA | 149 | W 11-2 | 91-58 | 2 | 45,734 | Erik Hiljus | Joel Pineiro | Erik Hiljus | Joel Pineiro | | 808 | 604 | 204 |
| 2001-09-23 | vs SEA | 150 | W 7-4 | 92-58 | 2 | 38,628 | Mark Mulder | Freddy Garcia | Mark Mulder | Freddy Garcia | Jason Isringhausen | 815 | 608 | 207 |
| 2001-09-25 | vs ANA | 151 | W 9-3 | 93-58 | 2 | 14,172 | Tim Hudson | Scott Schoeneweis | Tim Hudson | Shigetoshi Hasegawa | | 824 | 611 | 213 |
| 2001-09-26 | vs ANA | 152 | W 3-1 | 94-58 | 2 | 27,635 | Barry Zito | Jarrod Washburn | Barry Zito | Jarrod Washburn | Jason Isringhausen | 827 | 612 | 215 |
| 2001-09-27 | vs ANA | 153 | W 6-2 | 95-58 | 2 | 17,167 | Cory Lidle | Matt Wise | Cory Lidle | Matt Wise | | 833 | 614 | 219 |
| 2001-09-28 | @ SEA | 154 | L 3-5 | 95-59 | 2 | 45,695 | Mark Mulder | Freddy Garcia | Freddy Garcia | Mark Mulder | Kazuhiro Sasaki | 836 | 619 | 217 |
| 2001-09-29 | @ SEA | 155 | W 8-4 | 96-59 | 2 | 45,104 | Erik Hiljus | Jamie Moyer | Erik Hiljus | Jamie Moyer | | 844 | 623 | 221 |
| 2001-09-30 | @ SEA | 156 | L 3-6 | 96-60 | 2 | 45,674 | Tim Hudson | Aaron Sele | Aaron Sele | Tim Hudson | | 847 | 629 | 218 |
| 2001-10-02 | vs TEX | 157 | W 9-4 | 97-60 | 2 | 18,336 | Barry Zito | Darren Oliver | Barry Zito | Darren Oliver | | 856 | 633 | 223 |
| 2001-10-03 | vs TEX | 158 | W 5-4 | 98-60 | 2 | 23,740 | Cory Lidle | Rob Bell | Cory Lidle | Chris Michalak | Jason Isringhausen | 861 | 637 | 224 |
| 2001-10-04 | @ ANA | 159 | W 5-1 | 99-60 | 2 | 14,215 | Mark Mulder | Ismael Valdez | Mark Mulder | Ismael Valdez | | 866 | 638 | 228 |
| 2001-10-05 | @ ANA | 160 | W 6-2 | 100-60 | 2 | 26,343 | Tim Hudson | Ramon Ortiz | Tim Hudson | Ramon Ortiz | | 872 | 640 | 232 |
| 2001-10-06 | @ ANA | 161 | W 6-3 | 101-60 | 2 | 26,276 | Erik Hiljus | Scott Schoeneweis | Mike Magnante | Scott Schoeneweis | Jason Isringhausen | 878 | 643 | 235 |
| 2001-10-07 | @ ANA | 162 | W 6-2 | 102-60 | 2 | 18,682 | Barry Zito | Brian Cooper | Barry Zito | Brian Cooper | | 884 | 645 | 239 |