| 2001-04-02 | @ NYA | 1 | L 3-7 | 0-1 | 4 | 55,814 | Jeff Suppan | Roger Clemens | Roger Clemens | Jeff Suppan | | 3 | 7 | -4 |
| 2001-04-04 | @ NYA | 2 | L 2-8 | 0-2 | 5 | 26,499 | Blake Stein | Andy Pettitte | Andy Pettitte | Blake Stein | | 5 | 15 | -10 |
| 2001-04-05 | @ NYA | 3 | L 0-1 | 0-3 | 5 | 26,696 | Dan Reichert | Mike Mussina | Mike Mussina | Dan Reichert | Mariano Rivera | 5 | 16 | -11 |
| 2001-04-06 | vs MIN | 4 | L 2-6 | 0-4 | 5 | 40,150 | Brian Meadows | Joe Mays | Joe Mays | Brian Meadows | | 7 | 22 | -15 |
| 2001-04-07 | vs MIN | 5 | W 5-3 | 1-4 | 5 | 16,687 | Jeff Suppan | Mark Redman | Jeff Suppan | Mark Redman | Roberto Hernandez | 12 | 25 | -13 |
| 2001-04-08 | vs MIN | 6 | W 15-4 | 2-4 | 4 | 15,028 | Mac Suzuki | J.C. Romero | Mac Suzuki | J.C. Romero | | 27 | 29 | -2 |
| 2001-04-09 | vs NYA | 7 | L 4-13 | 2-5 | 5 | 24,411 | Blake Stein | Andy Pettitte | Andy Pettitte | Blake Stein | | 31 | 42 | -11 |
| 2001-04-10 | vs NYA | 8 | L 5-9 | 2-6 | 5 | 16,338 | Dan Reichert | Mike Mussina | Ramiro Mendoza | Roberto Hernandez | | 36 | 51 | -15 |
| 2001-04-11 | vs NYA | 9 | L 5-8 | 2-7 | 5 | 19,175 | Brian Meadows | Randy Keisler | Todd Williams | Brian Meadows | Mariano Rivera | 41 | 59 | -18 |
| 2001-04-13 | @ TOR | 10 | L 1-2 | 2-8 | 5 | 26,148 | Jeff Suppan | Chris Michalak | Chris Michalak | Jeff Suppan | Billy Koch | 42 | 61 | -19 |
| 2001-04-14 | @ TOR | 11 | L 4-5 | 2-9 | 5 | 26,024 | Mac Suzuki | Joey Hamilton | Bob File | Roberto Hernandez | | 46 | 66 | -20 |
| 2001-04-15 | @ TOR | 12 | W 4-2 | 3-9 | 5 | 21,379 | Blake Stein | Chris Carpenter | Blake Stein | Chris Carpenter | Roberto Hernandez | 50 | 68 | -18 |
| 2001-04-16 | @ MIN | 13 | W 5-3 | 4-9 | 5 | 10,297 | Dan Reichert | Joe Mays | Dan Reichert | Joe Mays | Roberto Hernandez | 55 | 71 | -16 |
| 2001-04-17 | @ MIN | 14 | L 5-6 | 4-10 | 5 | 10,623 | Brian Meadows | J.C. Romero | Bob Wells | Jason Grimsley | | 60 | 77 | -17 |
| 2001-04-18 | @ MIN | 15 | L 3-5 | 4-11 | 5 | 12,270 | Jeff Suppan | Mark Redman | Hector Carrasco | Tony Cogan | LaTroy Hawkins | 63 | 82 | -19 |
| 2001-04-20 | vs TOR | 16 | L 4-12 | 4-12 | 5 | 28,018 | Mac Suzuki | Chris Carpenter | Chris Carpenter | Mac Suzuki | | 67 | 94 | -27 |
| 2001-04-21 | vs TOR | 17 | W 5-4 | 5-12 | 5 | 18,246 | Blake Stein | Steve Parris | Doug Henry | Dan Plesac | | 72 | 98 | -26 |
| 2001-04-22 | vs TOR | 18 | W 5-1 | 6-12 | 4 | 17,371 | Dan Reichert | Esteban Loaiza | Dan Reichert | Esteban Loaiza | Roberto Hernandez | 77 | 99 | -22 |
| 2001-04-24 | @ TBA | 19 | L 2-4 | 6-13 | 4 | 11,056 | Brian Meadows | Albie Lopez | Albie Lopez | Brian Meadows | Esteban Yan | 79 | 103 | -24 |
| 2001-04-25 | @ TBA | 20 | L 3-5 | 6-14 | 4 | 11,119 | Jeff Suppan | Paul Wilson | Paul Wilson | Jeff Suppan | Esteban Yan | 82 | 108 | -26 |
| 2001-04-26 | @ TBA | 21 | W 6-0 | 7-14 | 4 | 11,083 | Mac Suzuki | Bryan Rekar | Mac Suzuki | Bryan Rekar | | 88 | 108 | -20 |
| 2001-04-27 | @ BOS | 22 | L 2-9 | 7-15 | 5 | 31,850 | Blake Stein | Frank Castillo | Frank Castillo | Blake Stein | Rolando Arrojo | 90 | 117 | -27 |
| 2001-04-28 | @ BOS | 23 | W 8-2 | 8-15 | 3 | 32,442 | Dan Reichert | Tomo Ohka | Dan Reichert | Tomo Ohka | | 98 | 119 | -21 |
| 2001-04-29 | @ BOS | 24 | W 11-8 | 9-15 | 3 | 32,791 | Brian Meadows | Paxton Crawford | Jose Santiago | Derek Lowe | Roberto Hernandez | 109 | 127 | -18 |
| 2001-04-30 | @ TOR | 25 | W 6-3 | 10-15 | 3 | 13,766 | Jeff Suppan | Joey Hamilton | Jeff Suppan | Joey Hamilton | Roberto Hernandez | 115 | 130 | -15 |
| 2001-05-01 | vs CLE | 26 | L 2-13 | 10-16 | 3 | 14,512 | Chad Durbin | Chuck Finley | Chuck Finley | Chad Durbin | | 117 | 143 | -26 |
| 2001-05-02 | vs CLE | 27 | L 4-8 | 10-17 | 4 | 13,401 | Mac Suzuki | CC Sabathia | CC Sabathia | Mac Suzuki | | 121 | 151 | -30 |
| 2001-05-03 | vs CLE | 28 | L 4-9 | 10-18 | 4 | 23,869 | Dan Reichert | Dave Burba | Dave Burba | Dan Reichert | | 125 | 160 | -35 |
| 2001-05-04 | vs MIN | 29 | L 2-6 | 10-19 | 4 | 16,075 | Brian Meadows | Mark Redman | Mark Redman | Brian Meadows | | 127 | 166 | -39 |
| 2001-05-05 | vs MIN | 30 | W 12-10 | 11-19 | 4 | 17,052 | Jeff Suppan | J.C. Romero | Cory Bailey | Travis Miller | | 139 | 176 | -37 |
| 2001-05-06 | vs MIN | 31 | L 2-4 | 11-20 | 4 | 16,480 | Chad Durbin | Brad Radke | Brad Radke | Chad Durbin | LaTroy Hawkins | 141 | 180 | -39 |
| 2001-05-08 | @ CLE | 32 | L 4-8 | 11-21 | 5 | 31,537 | Mac Suzuki | Dave Burba | Dave Burba | Tony Cogan | | 145 | 188 | -43 |
| 2001-05-09 | @ CLE | 33 | L 1-5 | 11-22 | 5 | 32,664 | Dan Reichert | CC Sabathia | CC Sabathia | Dan Reichert | | 146 | 193 | -47 |
| 2001-05-10 | @ CLE | 34 | W 8-3 | 12-22 | 5 | 34,502 | Brian Meadows | Bartolo Colon | Brian Meadows | Bartolo Colon | | 154 | 196 | -42 |
| 2001-05-11 | @ MIN | 35 | L 4-5 | 12-23 | 5 | 19,141 | Jeff Suppan | J.C. Romero | LaTroy Hawkins | Jose Santiago | | 158 | 201 | -43 |
| 2001-05-12 | @ MIN | 36 | W 12-4 | 13-23 | 5 | 26,167 | Chad Durbin | Brad Radke | Chad Durbin | Brad Radke | | 170 | 205 | -35 |
| 2001-05-13 | @ MIN | 37 | L 3-7 | 13-24 | 5 | 18,018 | Mac Suzuki | Eric Milton | Eric Milton | Mac Suzuki | | 173 | 212 | -39 |
| 2001-05-14 | @ MIN | 38 | L 1-3 | 13-25 | 5 | 10,049 | Dan Reichert | Joe Mays | Joe Mays | Dan Reichert | LaTroy Hawkins | 174 | 215 | -41 |
| 2001-05-15 | vs TBA | 39 | W 6-2 | 14-25 | 5 | 12,858 | Brian Meadows | Paul Wilson | Jose Santiago | Paul Wilson | | 180 | 217 | -37 |
| 2001-05-16 | vs TBA | 40 | W 9-5 | 15-25 | 5 | 12,378 | Jeff Suppan | Bryan Rekar | Roberto Hernandez | Esteban Yan | | 189 | 222 | -33 |
| 2001-05-17 | vs TBA | 41 | W 4-2 | 16-25 | 4 | 14,272 | Chad Durbin | Brian Rose | Chad Durbin | Brian Rose | Roberto Hernandez | 193 | 224 | -31 |
| 2001-05-18 | vs BOS | 42 | L 3-6 | 16-26 | 4 | 34,154 | Blake Stein | Pedro Martinez | Pedro Martinez | Blake Stein | | 196 | 230 | -34 |
| 2001-05-19 | vs BOS | 43 | W 6-2 | 17-26 | 4 | 26,583 | Dan Reichert | Hideo Nomo | Dan Reichert | Hideo Nomo | | 202 | 232 | -30 |
| 2001-05-20 | vs BOS | 44 | L 3-10 | 17-27 | 4 | 18,596 | Brian Meadows | Frank Castillo | Frank Castillo | Brian Meadows | | 205 | 242 | -37 |
| 2001-05-22 | vs OAK | 45 | L 1-4 | 17-28 | 4 | 15,233 | Jeff Suppan | Barry Zito | Jim Mecir | Jeff Suppan | Jason Isringhausen | 206 | 246 | -40 |
| 2001-05-23 | vs OAK | 46 | W 4-1 | 18-28 | 4 | 13,316 | Chad Durbin | Cory Lidle | Chad Durbin | Cory Lidle | Roberto Hernandez | 210 | 247 | -37 |
| 2001-05-25 | vs SEA | 47 | L 6-9 | 18-29 | 4 | 17,555 | Dan Reichert | John Halama | Ryan Franklin | Jason Grimsley | Kazuhiro Sasaki | 216 | 256 | -40 |
| 2001-05-26 | vs SEA | 48 | L 2-7 | 18-30 | 4 | 21,368 | Brian Meadows | Aaron Sele | Aaron Sele | Brian Meadows | | 218 | 263 | -45 |
| 2001-05-27 | vs SEA | 49 | L 4-5 | 18-31 | 5 | 19,524 | Jeff Suppan | Jamie Moyer | Norm Charlton | Jose Santiago | | 222 | 268 | -46 |
| 2001-05-28 | vs SEA | 50 | L 3-13 | 18-32 | 5 | 20,142 | Chad Durbin | Paul Abbott | Paul Abbott | Chad Durbin | | 225 | 281 | -56 |
| 2001-05-29 | @ TEX | 51 | L 2-8 | 18-33 | 5 | 28,606 | Mac Suzuki | Rick Helling | Rick Helling | Mac Suzuki | | 227 | 289 | -62 |
| 2001-05-30 | @ TEX | 52 | W 11-2 | 19-33 | 5 | 31,290 | Dan Reichert | Pat Mahomes | Dan Reichert | Pat Mahomes | | 238 | 291 | -53 |
| 2001-05-31 | @ TEX | 53 | W 8-2 | 20-33 | 5 | 31,472 | Blake Stein | Doug Davis | Blake Stein | Doug Davis | Kris Wilson | 246 | 293 | -47 |
| 2001-06-01 | @ ANA | 54 | L 1-7 | 20-34 | 5 | 30,783 | Jeff Suppan | Ismael Valdez | Ismael Valdez | Jeff Suppan | | 247 | 300 | -53 |
| 2001-06-02 | @ ANA | 55 | L 2-3 | 20-35 | 5 | 26,469 | Chad Durbin | Scott Schoeneweis | Scott Schoeneweis | Chad Durbin | Troy Percival | 249 | 303 | -54 |
| 2001-06-03 | @ ANA | 56 | L 2-7 | 20-36 | 5 | 31,810 | Mac Suzuki | Ramon Ortiz | Ramon Ortiz | Mac Suzuki | | 251 | 310 | -59 |
| 2001-06-05 | vs CHA | 57 | L 2-6 | 20-37 | 5 | 12,770 | Dan Reichert | Kip Wells | Kip Wells | Dan Reichert | Bob Howry | 253 | 316 | -63 |
| 2001-06-06 | vs CHA | 58 | W 12-6 | 21-37 | 5 | 13,394 | Jeff Suppan | James Baldwin | Jeff Suppan | James Baldwin | | 265 | 322 | -57 |
| 2001-06-07 | vs CHA | 59 | L 1-5 | 21-38 | 5 | 18,957 | Chad Durbin | Mark Buehrle | Mark Buehrle | Chad Durbin | | 266 | 327 | -61 |
| 2001-06-08 | vs ARI | 60 | L 4-11 | 21-39 | 5 | 20,349 | Paul Byrd | Randy Johnson | Randy Johnson | Paul Byrd | | 270 | 338 | -68 |
| 2001-06-09 | vs ARI | 61 | W 3-2 | 22-39 | 5 | 26,879 | Blake Stein | Armando Reynoso | Blake Stein | Armando Reynoso | Roberto Hernandez | 273 | 340 | -67 |
| 2001-06-10 | vs ARI | 62 | L 5-12 | 22-40 | 5 | 16,573 | Dan Reichert | Robert Ellis | Robert Ellis | Dan Reichert | | 278 | 352 | -74 |
| 2001-06-12 | vs SLN | 63 | W 7-4 | 23-40 | 5 | 27,914 | Chad Durbin | Darryl Kile | Chad Durbin | Darryl Kile | | 285 | 356 | -71 |
| 2001-06-13 | vs SLN | 64 | W 4-1 | 24-40 | 5 | 28,382 | Kris Wilson | Matt Morris | Kris Wilson | Matt Morris | Roberto Hernandez | 289 | 357 | -68 |
| 2001-06-14 | vs SLN | 65 | W 3-2 | 25-40 | 5 | 37,377 | Jeff Suppan | Mike Matthews | Doug Henry | Gene Stechschulte | | 292 | 359 | -67 |
| 2001-06-15 | @ MIL | 66 | W 4-2 | 26-40 | 5 | 39,005 | Blake Stein | Jamey Wright | Paul Byrd | Kyle Peterson | Roberto Hernandez | 296 | 361 | -65 |
| 2001-06-16 | @ MIL | 67 | W 4-1 | 27-40 | 5 | 43,060 | Dan Reichert | Jimmy Haynes | Dan Reichert | Jimmy Haynes | Roberto Hernandez | 300 | 362 | -62 |
| 2001-06-17 | @ MIL | 68 | L 2-5 | 27-41 | 5 | 42,554 | Blake Stein | Jamey Wright | Jamey Wright | Blake Stein | Curt Leskanic | 302 | 367 | -65 |
| 2001-06-18 | @ CHA | 69 | L 4-5 | 27-42 | 5 | 28,882 | Chad Durbin | Mark Buehrle | Mark Buehrle | Chad Durbin | Keith Foulke | 306 | 372 | -66 |
| 2001-06-19 | @ CHA | 70 | L 3-5 | 27-43 | 5 | 18,715 | Jeff Suppan | James Baldwin | James Baldwin | Jeff Suppan | Keith Foulke | 309 | 377 | -68 |
| 2001-06-20 | @ CHA | 71 | L 1-2 | 27-44 | 5 | 21,210 | Kris Wilson | Rocky Biddle | Jon Garland | Jason Grimsley | Keith Foulke | 310 | 379 | -69 |
| 2001-06-22 | vs CLE | 72 | L 5-6 | 27-45 | 5 | 31,572 | Paul Byrd | CC Sabathia | CC Sabathia | Blake Stein | Bob Wickman | 315 | 385 | -70 |
| 2001-06-23 | vs CLE | 73 | W 3-2 | 28-45 | 5 | 29,808 | Chad Durbin | Dave Burba | Chad Durbin | Dave Burba | Roberto Hernandez | 318 | 387 | -69 |
| 2001-06-24 | vs CLE | 74 | L 2-4 | 28-46 | 5 | 25,127 | Jeff Suppan | Bartolo Colon | Bartolo Colon | Jeff Suppan | John Rocker | 320 | 391 | -71 |
| 2001-06-26 | vs DET | 75 | W 12-5 | 29-46 | 5 | 13,966 | Dan Reichert | Willie Blair | Dan Reichert | Willie Blair | | 332 | 396 | -64 |
| 2001-06-27 | vs DET | 76 | W 5-4 | 30-46 | 5 | 15,207 | Paul Byrd | Jose Lima | Roberto Hernandez | Todd Jones | | 337 | 400 | -63 |
| 2001-06-28 | vs DET | 77 | W 9-2 | 31-46 | 5 | 22,239 | Chad Durbin | Jeff Weaver | Chad Durbin | Jeff Weaver | | 346 | 402 | -56 |
| 2001-06-29 | @ CLE | 78 | W 5-3 | 32-46 | 5 | 42,500 | Jeff Suppan | Dave Burba | Jeff Suppan | Dave Burba | Roberto Hernandez | 351 | 405 | -54 |
| 2001-06-30 | @ CLE | 79 | W 11-7 | 33-46 | 4 | 42,446 | Kris Wilson | Bartolo Colon | Kris Wilson | Bartolo Colon | | 362 | 412 | -50 |
| 2001-07-01 | @ CLE | 80 | W 13-11 | 34-46 | 4 | 42,457 | Dan Reichert | Charles Nagy | Blake Stein | Charles Nagy | Roberto Hernandez | 375 | 423 | -48 |
| 2001-07-02 | @ CLE | 81 | L 1-2 | 34-47 | 4 | 40,248 | Paul Byrd | CC Sabathia | John Rocker | Tony Cogan | | 376 | 425 | -49 |
| 2001-07-03 | @ DET | 82 | L 4-8 | 34-48 | 5 | 23,824 | Chad Durbin | Jose Lima | Jose Lima | Chad Durbin | | 380 | 433 | -53 |
| 2001-07-04 | @ DET | 83 | L 4-6 | 34-49 | 5 | 27,115 | Jeff Suppan | Jeff Weaver | Jeff Weaver | Cory Bailey | Matt Anderson | 384 | 439 | -55 |
| 2001-07-05 | @ DET | 84 | L 1-7 | 34-50 | 5 | 22,281 | Kris Wilson | Steve Sparks | Steve Sparks | Kris Wilson | | 385 | 446 | -61 |
| 2001-07-06 | vs HOU | 85 | L 3-8 | 34-51 | 5 | 23,905 | Dan Reichert | Wade Miller | Wade Miller | Dan Reichert | Nelson Cruz | 388 | 454 | -66 |
| 2001-07-07 | vs HOU | 86 | L 8-10 | 34-52 | 5 | 22,020 | Paul Byrd | Tim Redding | Michael Jackson | Paul Byrd | Billy Wagner | 396 | 464 | -68 |
| 2001-07-08 | vs HOU | 87 | L 5-14 | 34-53 | 5 | 14,951 | Chad Durbin | Scott Elarton | Ron Villone | Chad Durbin | | 401 | 478 | -77 |
| 2001-07-12 | @ PIT | 88 | L 0-2 | 34-54 | 5 | 26,393 | Jeff Suppan | Jimmy Anderson | Jimmy Anderson | Jeff Suppan | Mike Williams | 401 | 480 | -79 |
| 2001-07-13 | @ PIT | 89 | L 0-1 | 34-55 | 5 | 35,325 | Chad Durbin | Todd Ritchie | Todd Ritchie | Jason Grimsley | | 401 | 481 | -80 |
| 2001-07-14 | @ PIT | 90 | W 7-4 | 35-55 | 5 | 37,789 | Kris Wilson | David Williams | Kris Wilson | David Williams | Roberto Hernandez | 408 | 485 | -77 |
| 2001-07-15 | @ CHN | 91 | L 1-2 | 35-56 | 5 | 39,183 | Paul Byrd | Jon Lieber | Jon Lieber | Paul Byrd | Tom Gordon | 409 | 487 | -78 |
| 2001-07-16 | @ CHN | 92 | W 4-2 | 36-56 | 5 | 39,769 | Dan Reichert | Kevin Tapani | Dan Reichert | Kevin Tapani | Roberto Hernandez | 413 | 489 | -76 |
| 2001-07-17 | @ CHN | 93 | L 4-7 | 36-57 | 5 | 38,013 | Jeff Suppan | Jason Bere | Jason Bere | Tony Cogan | Tom Gordon | 417 | 496 | -79 |
| 2001-07-18 | vs SEA | 94 | L 0-2 | 36-58 | 5 | 15,818 | Chad Durbin | Jamie Moyer | Jeff Nelson | Roberto Hernandez | Kazuhiro Sasaki | 417 | 498 | -81 |
| 2001-07-19 | vs SEA | 95 | W 6-3 | 37-58 | 5 | 21,566 | Kris Wilson | Freddy Garcia | Kris Wilson | Freddy Garcia | | 423 | 501 | -78 |
| 2001-07-20 | vs OAK | 96 | L 3-14 | 37-59 | 5 | 30,523 | Paul Byrd | Cory Lidle | Cory Lidle | Paul Byrd | | 426 | 515 | -89 |
| 2001-07-21 | vs OAK | 97 | L 1-10 | 37-60 | 5 | 25,830 | Dan Reichert | Gil Heredia | Gil Heredia | Dan Reichert | | 427 | 525 | -98 |
| 2001-07-22 | vs OAK | 98 | W 5-4 | 38-60 | 5 | 17,252 | Jeff Suppan | Mark Mulder | Roberto Hernandez | Jim Mecir | | 432 | 529 | -97 |
| 2001-07-23 | vs OAK | 99 | L 2-7 | 38-61 | 5 | 20,807 | Chad Durbin | Tim Hudson | Tim Hudson | Chad Durbin | | 434 | 536 | -102 |
| 2001-07-24 | @ SEA | 100 | W 6-1 | 39-61 | 5 | 45,119 | Kris Wilson | Freddy Garcia | Kris Wilson | Freddy Garcia | | 440 | 537 | -97 |
| 2001-07-25 | @ SEA | 101 | W 5-1 | 40-61 | 5 | 45,265 | Paul Byrd | Aaron Sele | Paul Byrd | Aaron Sele | | 445 | 538 | -93 |
| 2001-07-26 | @ SEA | 102 | L 0-4 | 40-62 | 5 | 44,519 | Chris George | Joel Pineiro | Joel Pineiro | Chris George | | 445 | 542 | -97 |
| 2001-07-27 | @ OAK | 103 | L 0-5 | 40-63 | 5 | 14,413 | Jeff Suppan | Mark Mulder | Mark Mulder | Jeff Suppan | | 445 | 547 | -102 |
| 2001-07-28 | @ OAK | 104 | W 9-3 | 41-63 | 5 | 40,242 | Chad Durbin | Tim Hudson | Chad Durbin | Tim Hudson | | 454 | 550 | -96 |
| 2001-07-29 | @ OAK | 105 | L 4-6 | 41-64 | 5 | 19,384 | Kris Wilson | Barry Zito | Jason Isringhausen | Jason Grimsley | Jim Mecir | 458 | 556 | -98 |
| 2001-07-31 | @ CHA | 106 | W 2-1 | 42-64 | 5 | 18,581 | Paul Byrd | Jon Garland | Paul Byrd | Keith Foulke | Roberto Hernandez | 460 | 557 | -97 |
| 2001-08-01 | @ CHA | 107 | L 6-7 | 42-65 | 5 | 15,620 | Chris George | Dan Wright | Dan Wright | Chris George | Keith Foulke | 466 | 564 | -98 |
| 2001-08-02 | @ CHA | 108 | W 6-3 | 43-65 | 5 | 16,021 | Jeff Suppan | Kip Wells | Jeff Suppan | Kip Wells | Roberto Hernandez | 472 | 567 | -95 |
| 2001-08-03 | @ MIN | 109 | L 7-8 | 43-66 | 5 | 21,006 | Chad Durbin | Brad Radke | Todd Jones | Roberto Hernandez | | 479 | 575 | -96 |
| 2001-08-04 | @ MIN | 110 | L 2-6 | 43-67 | 5 | 32,559 | Kris Wilson | Eric Milton | Eric Milton | Kris Wilson | | 481 | 581 | -100 |
| 2001-08-05 | @ MIN | 111 | W 10-5 | 44-67 | 5 | 24,363 | Paul Byrd | Joe Mays | Paul Byrd | Joe Mays | | 491 | 586 | -95 |
| 2001-08-06 | vs BAL | 112 | L 6-9 | 44-68 | 5 | 22,578 | Chris George | Jason Johnson | Jason Johnson | Chris George | | 497 | 595 | -98 |
| 2001-08-07 | vs BAL | 113 | L 3-7 | 44-69 | 5 | 17,266 | Jeff Suppan | Calvin Maduro | Calvin Maduro | Jeff Suppan | Willis Roberts | 500 | 602 | -102 |
| 2001-08-08 | vs BAL | 114 | L 1-4 | 44-70 | 5 | 17,885 | Chad Durbin | Jose Mercedes | Jose Mercedes | Chad Durbin | Buddy Groom | 501 | 606 | -105 |
| 2001-08-09 | vs BAL | 115 | W 6-4 | 45-70 | 5 | 31,832 | Kris Wilson | Sidney Ponson | Kris Wilson | Sidney Ponson | Roberto Hernandez | 507 | 610 | -103 |
| 2001-08-10 | vs DET | 116 | W 7-3 | 46-70 | 5 | 22,107 | Paul Byrd | Jeff Weaver | Paul Byrd | Jeff Weaver | Blake Stein | 514 | 613 | -99 |
| 2001-08-11 | vs DET | 117 | W 4-1 | 47-70 | 5 | 26,943 | Chris George | Jose Lima | Chris George | Jose Lima | Roberto Hernandez | 518 | 614 | -96 |
| 2001-08-12 | vs DET | 118 | W 6-4 | 48-70 | 5 | 17,811 | Jeff Suppan | Adam Pettyjohn | Jeff Suppan | Adam Pettyjohn | Roberto Hernandez | 524 | 618 | -94 |
| 2001-08-14 | @ BAL | 119 | L 2-5 | 48-71 | 5 | 40,539 | Chad Durbin | Calvin Maduro | Calvin Maduro | Chad Durbin | Willis Roberts | 526 | 623 | -97 |
| 2001-08-15 | @ BAL | 120 | L 4-5 | 48-72 | 5 | 38,545 | Kris Wilson | Jose Mercedes | Jose Mercedes | Kris Wilson | Willis Roberts | 530 | 628 | -98 |
| 2001-08-16 | @ BAL | 121 | W 9-2 | 49-72 | 5 | 40,788 | Paul Byrd | Sidney Ponson | Paul Byrd | Sidney Ponson | | 539 | 630 | -91 |
| 2001-08-17 | @ DET | 122 | L 2-4 | 49-73 | 5 | 30,214 | Chris George | Jose Lima | Jose Lima | Chris George | Matt Anderson | 541 | 634 | -93 |
| 2001-08-18 | @ DET | 123 | W 8-4 | 50-73 | 5 | 31,897 | Jeff Suppan | Adam Pettyjohn | Jeff Suppan | C.J. Nitkowski | | 549 | 638 | -89 |
| 2001-08-19 | @ DET | 124 | L 3-4 | 50-74 | 5 | 26,898 | Chad Durbin | Nate Cornejo | Nate Cornejo | Chad Durbin | Matt Anderson | 552 | 642 | -90 |
| 2001-08-20 | vs CHA | 125 | W 10-1 | 51-74 | 5 | 13,842 | Blake Stein | Sean Lowe | Blake Stein | Sean Lowe | | 562 | 643 | -81 |
| 2001-08-21 | vs CHA | 126 | L 1-6 | 51-75 | 5 | 12,391 | Paul Byrd | Jon Garland | Jon Garland | Paul Byrd | | 563 | 649 | -86 |
| 2001-08-22 | vs CHA | 127 | L 12-13 | 51-76 | 5 | 11,670 | Chris George | Dan Wright | Kip Wells | Doug Henry | Keith Foulke | 575 | 662 | -87 |
| 2001-08-23 | vs CHA | 128 | L 6-7 | 51-77 | 5 | 13,541 | Jeff Suppan | Gary Glover | Rocky Biddle | Jeff Suppan | Keith Foulke | 581 | 669 | -88 |
| 2001-08-24 | vs MIN | 129 | L 3-9 | 51-78 | 5 | 16,352 | Chad Durbin | Eric Milton | Eric Milton | Chad Durbin | Eddie Guardado | 584 | 678 | -94 |
| 2001-08-25 | vs MIN | 130 | L 1-7 | 51-79 | 5 | 22,634 | Kris Wilson | Joe Mays | Joe Mays | Kris Wilson | | 585 | 685 | -100 |
| 2001-08-26 | vs MIN | 131 | L 2-7 | 51-80 | 5 | 13,575 | Blake Stein | Brad Radke | Brad Radke | Blake Stein | | 587 | 692 | -105 |
| 2001-08-28 | vs ANA | 132 | W 10-4 | 52-80 | 5 | 11,479 | Chris George | Ramon Ortiz | Chris George | Ramon Ortiz | | 597 | 696 | -99 |
| 2001-08-29 | vs ANA | 133 | W 6-3 | 53-80 | 5 | 11,190 | Jeff Suppan | Pat Rapp | Jeff Suppan | Pat Rapp | Roberto Hernandez | 603 | 699 | -96 |
| 2001-08-30 | vs ANA | 134 | W 2-1 | 54-80 | 5 | 12,159 | Chad Durbin | Jarrod Washburn | Jason Grimsley | Al Levine | | 605 | 700 | -95 |
| 2001-08-31 | vs TEX | 135 | L 2-7 | 54-81 | 5 | 15,071 | Paul Byrd | Rick Helling | Rick Helling | Paul Byrd | | 607 | 707 | -100 |
| 2001-09-01 | vs TEX | 136 | W 8-7 | 55-81 | 5 | 24,160 | Kris Wilson | Doug Davis | Roberto Hernandez | Pat Mahomes | | 615 | 714 | -99 |
| 2001-09-02 | vs TEX | 137 | L 6-12 | 55-82 | 5 | 18,389 | Chris George | Darren Oliver | Chris Michalak | Chris George | | 621 | 726 | -105 |
| 2001-09-04 | @ ANA | 138 | W 4-1 | 56-82 | 4 | 13,950 | Jeff Suppan | Jarrod Washburn | Jeff Suppan | Jarrod Washburn | | 625 | 727 | -102 |
| 2001-09-05 | @ ANA | 139 | L 1-4 | 56-83 | 4 | 13,998 | Chad Durbin | Ismael Valdez | Ismael Valdez | Chad Durbin | Troy Percival | 626 | 731 | -105 |
| 2001-09-06 | @ ANA | 140 | L 6-7 | 56-84 | 5 | 13,763 | Paul Byrd | Scott Schoeneweis | Mike Holtz | Roberto Hernandez | | 632 | 738 | -106 |
| 2001-09-07 | @ TEX | 141 | L 2-8 | 56-85 | 5 | 29,954 | Kris Wilson | Doug Davis | Doug Davis | Kris Wilson | | 634 | 746 | -112 |
| 2001-09-08 | @ TEX | 142 | W 8-3 | 57-85 | 5 | 37,501 | Chris George | Darren Oliver | Chris George | Darren Oliver | | 642 | 749 | -107 |
| 2001-09-09 | @ TEX | 143 | L 3-4 | 57-86 | 5 | 24,057 | Jeff Suppan | Rob Bell | Jeff Zimmerman | Roberto Hernandez | | 645 | 753 | -108 |
| 2001-09-18 | @ CLE | 144 | L 2-11 | 57-87 | 5 | 34,795 | Chad Durbin | Chuck Finley | Chuck Finley | Chad Durbin | | 647 | 764 | -117 |
| 2001-09-19 | @ CLE | 145 | L 3-11 | 57-88 | 5 | 31,357 | Jeff Suppan | Bartolo Colon | Bartolo Colon | Jeff Suppan | | 650 | 775 | -125 |
| 2001-09-20 | @ CLE | 146 | W 4-2 | 58-88 | 5 | 33,912 | Chris George | Ryan Drese | Chris George | Ryan Drese | Roberto Hernandez | 654 | 777 | -123 |
| 2001-09-21 | @ CHA | 147 | L 7-8 | 58-89 | 5 | 15,404 | Kris Wilson | Dan Wright | Sean Lowe | Doug Henry | | 661 | 785 | -124 |
| 2001-09-22 | @ CHA | 148 | L 4-5 | 58-90 | 5 | 24,307 | Mike MacDougal | Jon Garland | Keith Foulke | Blake Stein | | 665 | 790 | -125 |
| 2001-09-23 | @ CHA | 149 | L 2-10 | 58-91 | 5 | 19,014 | Chad Durbin | Mark Buehrle | Mark Buehrle | Chad Durbin | | 667 | 800 | -133 |
| 2001-09-24 | vs DET | 150 | L 2-4 | 58-92 | 5 | 12,152 | Jeff Suppan | Steve Sparks | Steve Sparks | Jeff Suppan | Matt Anderson | 669 | 804 | -135 |
| 2001-09-25 | vs DET | 151 | L 4-6 | 58-93 | 5 | 11,160 | Chris George | Jose Lima | Jose Lima | Chris George | Matt Anderson | 673 | 810 | -137 |
| 2001-09-26 | vs DET | 152 | W 8-6 | 59-93 | 5 | 11,097 | Blake Stein | Heath Murray | Blake Stein | Heath Murray | Roberto Hernandez | 681 | 816 | -135 |
| 2001-09-27 | vs DET | 153 | W 8-7 | 60-93 | 5 | 11,978 | Mike MacDougal | Nate Cornejo | Mike MacDougal | Nate Cornejo | Roberto Hernandez | 689 | 823 | -134 |
| 2001-09-28 | vs CHA | 154 | W 3-2 | 61-93 | 5 | 14,914 | Chad Durbin | Jon Garland | Chad Durbin | Alan Embree | Roberto Hernandez | 692 | 825 | -133 |
| 2001-09-29 | vs CHA | 155 | L 2-10 | 61-94 | 5 | 16,443 | Jeff Suppan | Mark Buehrle | Mark Buehrle | Jeff Suppan | | 694 | 835 | -141 |
| 2001-09-30 | vs CHA | 156 | L 2-5 | 61-95 | 5 | 12,235 | Chris George | Gary Glover | Gary Glover | Chris George | Keith Foulke | 696 | 840 | -144 |
| 2001-10-02 | vs CLE | 157 | W 5-1 | 62-95 | 5 | 12,016 | Blake Stein | Ryan Drese | Roberto Hernandez | John Rocker | | 701 | 841 | -140 |
| 2001-10-03 | vs CLE | 158 | L 1-4 | 62-96 | 5 | 12,581 | Mike MacDougal | CC Sabathia | CC Sabathia | Mike MacDougal | Bob Wickman | 702 | 845 | -143 |
| 2001-10-04 | vs CLE | 159 | W 8-4 | 63-96 | 5 | 12,672 | Chad Durbin | Bartolo Colon | Chad Durbin | Bartolo Colon | | 710 | 849 | -139 |
| 2001-10-06 | @ DET | 160 | W 8-3 | 64-97 | 5 | 0 | Jeff Suppan | Jeff Weaver | Jeff Suppan | Jeff Weaver | Roberto Hernandez | 718 | 852 | -134 |
| 2001-10-06 | @ DET | 161 | L 1-2 | 64-97 | 5 | 18,844 | Chris George | Steve Sparks | Steve Sparks | Chris George | | 719 | 854 | -135 |
| 2001-10-07 | @ DET | 162 | W 10-4 | 65-97 | 5 | 19,261 | Blake Stein | Jose Lima | Blake Stein | Jose Lima | | 729 | 858 | -129 |