| 2001-04-03 | @ TEX | 1 | L 2-3 | 0-1 | 4 | 49,512 | Scott Schoeneweis | Kenny Rogers | Kenny Rogers | Scott Schoeneweis | Tim Crabtree | 2 | 3 | -1 |
| 2001-04-04 | @ TEX | 2 | L 3-7 | 0-2 | 4 | 34,321 | Pat Rapp | Darren Oliver | Darren Oliver | Pat Rapp | | 5 | 10 | -5 |
| 2001-04-05 | @ TEX | 3 | W 10-3 | 1-2 | 3 | 34,120 | Ramon Ortiz | Ryan Glynn | Ramon Ortiz | Ryan Glynn | | 15 | 13 | 2 |
| 2001-04-06 | @ OAK | 4 | W 5-4 | 2-2 | 2 | 42,826 | Matt Wise | Mark Mulder | Matt Wise | Mark Mulder | Troy Percival | 20 | 17 | 3 |
| 2001-04-07 | @ OAK | 5 | L 2-4 | 2-3 | 2 | 21,398 | Steve Green | Tim Hudson | Tim Hudson | Al Levine | Jason Isringhausen | 22 | 21 | 1 |
| 2001-04-08 | @ OAK | 6 | W 6-4 | 3-3 | 2 | 26,211 | Scott Schoeneweis | Barry Zito | Scott Schoeneweis | Barry Zito | Troy Percival | 28 | 25 | 3 |
| 2001-04-10 | vs TEX | 7 | L 5-7 | 3-4 | 3 | 42,784 | Pat Rapp | Darren Oliver | Darren Oliver | Pat Rapp | Tim Crabtree | 33 | 32 | 1 |
| 2001-04-11 | vs TEX | 8 | W 7-2 | 4-4 | 2 | 16,974 | Ramon Ortiz | Ryan Glynn | Ramon Ortiz | Ryan Glynn | | 40 | 34 | 6 |
| 2001-04-12 | vs TEX | 9 | W 13-3 | 5-4 | 2 | 17,435 | Matt Wise | Rick Helling | Lou Pote | Rick Helling | | 53 | 37 | 16 |
| 2001-04-13 | vs SEA | 10 | W 4-3 | 6-4 | 2 | 31,087 | Scott Schoeneweis | Brett Tomko | Shigetoshi Hasegawa | Kazuhiro Sasaki | | 57 | 40 | 17 |
| 2001-04-14 | vs SEA | 11 | L 1-2 | 6-5 | 2 | 34,780 | Ismael Valdez | Freddy Garcia | Freddy Garcia | Ismael Valdez | Kazuhiro Sasaki | 58 | 42 | 16 |
| 2001-04-15 | vs SEA | 12 | L 5-7 | 6-6 | 3 | 20,733 | Pat Rapp | John Halama | Jose Paniagua | Shigetoshi Hasegawa | Jeff Nelson | 63 | 49 | 14 |
| 2001-04-16 | vs OAK | 13 | L 3-6 | 6-7 | 3 | 16,368 | Jarrod Washburn | Mark Mulder | Mark Mulder | Jarrod Washburn | Jason Isringhausen | 66 | 55 | 11 |
| 2001-04-17 | vs OAK | 14 | L 1-5 | 6-8 | 3 | 17,837 | Ramon Ortiz | Tim Hudson | Tim Hudson | Ramon Ortiz | | 67 | 60 | 7 |
| 2001-04-18 | vs OAK | 15 | W 3-2 | 7-8 | 3 | 17,962 | Scott Schoeneweis | Cory Lidle | Troy Percival | Jim Mecir | | 70 | 62 | 8 |
| 2001-04-19 | @ SEA | 16 | L 2-3 | 7-9 | 3 | 25,016 | Ismael Valdez | Freddy Garcia | Freddy Garcia | Ismael Valdez | Kazuhiro Sasaki | 72 | 65 | 7 |
| 2001-04-20 | @ SEA | 17 | L 1-4 | 7-10 | 3 | 38,518 | Pat Rapp | John Halama | John Halama | Pat Rapp | Kazuhiro Sasaki | 73 | 69 | 4 |
| 2001-04-21 | @ SEA | 18 | L 2-5 | 7-11 | 3 | 39,274 | Jarrod Washburn | Jamie Moyer | Jamie Moyer | Jarrod Washburn | Jeff Nelson | 75 | 74 | 1 |
| 2001-04-22 | @ SEA | 19 | L 0-5 | 7-12 | 3 | 44,192 | Ramon Ortiz | Aaron Sele | Aaron Sele | Ramon Ortiz | | 75 | 79 | -4 |
| 2001-04-24 | @ CLE | 20 | W 7-2 | 8-12 | 3 | 31,942 | Scott Schoeneweis | Bartolo Colon | Scott Schoeneweis | Bartolo Colon | | 82 | 81 | 1 |
| 2001-04-25 | @ CLE | 21 | W 3-1 | 9-12 | 3 | 31,396 | Ismael Valdez | CC Sabathia | Ismael Valdez | CC Sabathia | Troy Percival | 85 | 82 | 3 |
| 2001-04-26 | @ CLE | 22 | L 5-6 | 9-13 | 3 | 29,427 | Pat Rapp | Chuck Finley | Paul Shuey | Shigetoshi Hasegawa | Bob Wickman | 90 | 88 | 2 |
| 2001-04-27 | @ TOR | 23 | L 4-12 | 9-14 | 3 | 16,174 | Jarrod Washburn | Esteban Loaiza | Esteban Loaiza | Jarrod Washburn | | 94 | 100 | -6 |
| 2001-04-28 | @ TOR | 24 | W 4-1 | 10-14 | 3 | 19,261 | Ramon Ortiz | Chris Michalak | Ramon Ortiz | Chris Michalak | Troy Percival | 98 | 101 | -3 |
| 2001-04-29 | @ TOR | 25 | L 0-2 | 10-15 | 3 | 23,949 | Scott Schoeneweis | Steve Parris | Steve Parris | Scott Schoeneweis | Billy Koch | 98 | 103 | -5 |
| 2001-05-01 | vs CHA | 26 | W 6-4 | 11-15 | 2 | 15,664 | Pat Rapp | David Wells | Pat Rapp | David Wells | Troy Percival | 104 | 107 | -3 |
| 2001-05-02 | vs CHA | 27 | W 12-5 | 12-15 | 2 | 15,516 | Jarrod Washburn | Jon Garland | Jarrod Washburn | Jon Garland | | 116 | 112 | 4 |
| 2001-05-03 | vs CHA | 28 | W 3-1 | 13-15 | 2 | 15,372 | Ismael Valdez | James Baldwin | Ismael Valdez | James Baldwin | Troy Percival | 119 | 113 | 6 |
| 2001-05-04 | vs DET | 29 | W 7-5 | 14-15 | 2 | 36,690 | Scott Schoeneweis | Matt Perisho | Ben Weber | Heath Murray | Troy Percival | 126 | 118 | 8 |
| 2001-05-05 | vs DET | 30 | L 2-11 | 14-16 | 2 | 24,758 | Ramon Ortiz | Jeff Weaver | Jeff Weaver | Ramon Ortiz | | 128 | 129 | -1 |
| 2001-05-06 | vs DET | 31 | W 3-2 | 15-16 | 2 | 29,353 | Pat Rapp | Steve Sparks | Al Levine | Danny Patterson | | 131 | 131 | 0 |
| 2001-05-08 | @ CHA | 32 | L 0-2 | 15-17 | 2 | 13,187 | Jarrod Washburn | James Baldwin | James Baldwin | Jarrod Washburn | | 131 | 133 | -2 |
| 2001-05-09 | @ CHA | 33 | L 5-6 | 15-18 | 2 | 13,458 | Ismael Valdez | Mark Buehrle | Bob Howry | Al Levine | | 136 | 139 | -3 |
| 2001-05-10 | @ CHA | 34 | W 7-6 | 16-18 | 2 | 12,684 | Al Levine | Rocky Biddle | Troy Percival | Keith Foulke | | 143 | 145 | -2 |
| 2001-05-11 | @ DET | 35 | L 6-7 | 16-19 | 2 | 18,811 | Ramon Ortiz | Steve Sparks | Todd Jones | Mark Lukasiewicz | | 149 | 152 | -3 |
| 2001-05-12 | @ DET | 36 | L 1-4 | 16-20 | 2 | 22,133 | Pat Rapp | Victor Santos | Matt Anderson | Shigetoshi Hasegawa | | 150 | 156 | -6 |
| 2001-05-13 | @ DET | 37 | W 14-2 | 17-20 | 2 | 20,012 | Jarrod Washburn | Chris Holt | Jarrod Washburn | Chris Holt | | 164 | 158 | 6 |
| 2001-05-15 | vs TOR | 38 | L 3-9 | 17-21 | 2 | 15,904 | Ismael Valdez | Chris Michalak | Chris Michalak | Ismael Valdez | | 167 | 167 | 0 |
| 2001-05-16 | vs TOR | 39 | W 3-1 | 18-21 | 2 | 15,611 | Scott Schoeneweis | Steve Parris | Scott Schoeneweis | Steve Parris | Troy Percival | 170 | 168 | 2 |
| 2001-05-17 | vs TOR | 40 | W 4-2 | 19-21 | 2 | 15,204 | Ramon Ortiz | Joey Hamilton | Shigetoshi Hasegawa | Kelvim Escobar | Troy Percival | 174 | 170 | 4 |
| 2001-05-18 | vs CLE | 41 | L 2-7 | 19-22 | 2 | 39,177 | Pat Rapp | Dave Burba | Dave Burba | Pat Rapp | | 176 | 177 | -1 |
| 2001-05-19 | vs CLE | 42 | L 3-4 | 19-23 | 3 | 40,019 | Jarrod Washburn | Jaret Wright | Paul Shuey | Troy Percival | Bob Wickman | 179 | 181 | -2 |
| 2001-05-20 | vs CLE | 43 | W 9-6 | 20-23 | 3 | 36,339 | Ismael Valdez | CC Sabathia | Al Levine | Rich Rodriguez | Troy Percival | 188 | 187 | 1 |
| 2001-05-23 | @ BAL | 44 | L 5-12 | 20-24 | 3 | 31,249 | Scott Schoeneweis | Willis Roberts | Willis Roberts | Scott Schoeneweis | | 193 | 199 | -6 |
| 2001-05-24 | @ BAL | 45 | L 4-6 | 20-25 | 3 | 34,555 | Ramon Ortiz | Jason Johnson | Jason Johnson | Ramon Ortiz | B.J. Ryan | 197 | 205 | -8 |
| 2001-05-25 | @ TBA | 46 | W 6-4 | 21-25 | 3 | 10,946 | Pat Rapp | Albie Lopez | Ben Weber | Albie Lopez | Troy Percival | 203 | 209 | -6 |
| 2001-05-26 | @ TBA | 47 | W 10-4 | 22-25 | 3 | 13,496 | Jarrod Washburn | Paul Wilson | Jarrod Washburn | Paul Wilson | | 213 | 213 | 0 |
| 2001-05-27 | @ TBA | 48 | L 3-4 | 22-26 | 3 | 11,808 | Ismael Valdez | Bryan Rekar | Esteban Yan | Al Levine | | 216 | 217 | -1 |
| 2001-05-28 | @ TBA | 49 | W 3-1 | 23-26 | 3 | 11,127 | Scott Schoeneweis | Ryan Rupe | Scott Schoeneweis | Rusty Meacham | Troy Percival | 219 | 218 | 1 |
| 2001-05-29 | vs MIN | 50 | L 5-6 | 23-27 | 3 | 14,975 | Ramon Ortiz | Eric Milton | Jack Cressend | Al Levine | Hector Carrasco | 224 | 224 | 0 |
| 2001-05-30 | vs MIN | 51 | L 0-3 | 23-28 | 3 | 14,913 | Pat Rapp | Joe Mays | Joe Mays | Pat Rapp | | 224 | 227 | -3 |
| 2001-05-31 | vs MIN | 52 | W 5-4 | 24-28 | 3 | 15,159 | Jarrod Washburn | Brad Thomas | Ben Weber | Hector Carrasco | | 229 | 231 | -2 |
| 2001-06-01 | vs KCA | 53 | W 7-1 | 25-28 | 3 | 30,783 | Ismael Valdez | Jeff Suppan | Ismael Valdez | Jeff Suppan | | 236 | 232 | 4 |
| 2001-06-02 | vs KCA | 54 | W 3-2 | 26-28 | 2 | 26,469 | Scott Schoeneweis | Chad Durbin | Scott Schoeneweis | Chad Durbin | Troy Percival | 239 | 234 | 5 |
| 2001-06-03 | vs KCA | 55 | W 7-2 | 27-28 | 2 | 31,810 | Ramon Ortiz | Mac Suzuki | Ramon Ortiz | Mac Suzuki | | 246 | 236 | 10 |
| 2001-06-05 | vs OAK | 56 | W 7-3 | 28-28 | 2 | 16,166 | Jarrod Washburn | Mark Mulder | Jarrod Washburn | Mark Mulder | | 253 | 239 | 14 |
| 2001-06-06 | vs OAK | 57 | L 1-4 | 28-29 | 2 | 15,356 | Pat Rapp | Tim Hudson | Tim Hudson | Pat Rapp | Jason Isringhausen | 254 | 243 | 11 |
| 2001-06-07 | vs OAK | 58 | W 6-4 | 29-29 | 2 | 15,859 | Scott Schoeneweis | Barry Zito | Scott Schoeneweis | Barry Zito | Troy Percival | 260 | 247 | 13 |
| 2001-06-08 | @ LAN | 59 | W 1-0 | 30-29 | 2 | 37,449 | Ismael Valdez | Giovanni Carrara | Ismael Valdez | Giovanni Carrara | Troy Percival | 261 | 247 | 14 |
| 2001-06-09 | @ LAN | 60 | L 1-2 | 30-30 | 2 | 54,415 | Ramon Ortiz | Chan Ho Park | Jeff Shaw | Ben Weber | | 262 | 249 | 13 |
| 2001-06-10 | @ LAN | 61 | W 6-5 | 31-30 | 2 | 45,260 | Jarrod Washburn | Terry Adams | Al Levine | Eric Gagne | Troy Percival | 268 | 254 | 14 |
| 2001-06-12 | @ SFN | 62 | L 2-3 | 31-31 | 2 | 36,422 | Pat Rapp | Kirk Rueter | Kirk Rueter | Pat Rapp | Robb Nen | 270 | 257 | 13 |
| 2001-06-13 | @ SFN | 63 | L 0-1 | 31-32 | 3 | 37,119 | Scott Schoeneweis | Russ Ortiz | Russ Ortiz | Scott Schoeneweis | Robb Nen | 270 | 258 | 12 |
| 2001-06-14 | @ SFN | 64 | L 4-10 | 31-33 | 3 | 40,478 | Ismael Valdez | Mark Gardner | Mark Gardner | Ismael Valdez | | 274 | 268 | 6 |
| 2001-06-15 | vs LAN | 65 | L 2-6 | 31-34 | 3 | 42,287 | Ramon Ortiz | Chan Ho Park | Chan Ho Park | Ramon Ortiz | Mike Fetters | 276 | 274 | 2 |
| 2001-06-16 | vs LAN | 66 | W 6-5 | 32-34 | 2 | 43,429 | Jarrod Washburn | Terry Adams | Troy Percival | Matt Herges | | 282 | 279 | 3 |
| 2001-06-17 | vs LAN | 67 | W 6-4 | 33-34 | 2 | 43,001 | Pat Rapp | Luke Prokopec | Al Levine | Jeff Shaw | | 288 | 283 | 5 |
| 2001-06-19 | @ TEX | 68 | L 5-7 | 33-35 | 2 | 31,158 | Scott Schoeneweis | Rob Bell | Juan Moreno | Scott Schoeneweis | Jeff Zimmerman | 293 | 290 | 3 |
| 2001-06-20 | @ TEX | 69 | W 4-3 | 34-35 | 2 | 31,789 | Ramon Ortiz | Kenny Rogers | Ramon Ortiz | Kenny Rogers | Troy Percival | 297 | 293 | 4 |
| 2001-06-21 | @ TEX | 70 | L 3-4 | 34-36 | 2 | 30,337 | Matt Wise | Rick Helling | Rick Helling | Matt Wise | Jeff Zimmerman | 300 | 297 | 3 |
| 2001-06-22 | @ SEA | 71 | W 8-1 | 35-36 | 2 | 45,461 | Jarrod Washburn | Aaron Sele | Jarrod Washburn | Aaron Sele | | 308 | 298 | 10 |
| 2001-06-23 | @ SEA | 72 | W 2-1 | 36-36 | 2 | 45,430 | Pat Rapp | Jamie Moyer | Pat Rapp | Jamie Moyer | Troy Percival | 310 | 299 | 11 |
| 2001-06-24 | @ SEA | 73 | L 3-7 | 36-37 | 2 | 45,722 | Scott Schoeneweis | Paul Abbott | Paul Abbott | Scott Schoeneweis | Kazuhiro Sasaki | 313 | 306 | 7 |
| 2001-06-25 | vs TEX | 74 | W 11-7 | 37-37 | 2 | 17,076 | Ramon Ortiz | Kenny Rogers | Ramon Ortiz | Kenny Rogers | | 324 | 313 | 11 |
| 2001-06-26 | vs TEX | 75 | L 1-8 | 37-38 | 2 | 17,250 | Matt Wise | Rick Helling | Jeff Zimmerman | Mark Lukasiewicz | | 325 | 321 | 4 |
| 2001-06-27 | vs TEX | 76 | W 4-2 | 38-38 | 2 | 17,302 | Jarrod Washburn | Doug Davis | Jarrod Washburn | Doug Davis | Troy Percival | 329 | 323 | 6 |
| 2001-06-28 | vs TEX | 77 | L 3-6 | 38-39 | 2 | 17,951 | Pat Rapp | Darren Oliver | Darren Oliver | Pat Rapp | Jeff Zimmerman | 332 | 329 | 3 |
| 2001-06-29 | vs SEA | 78 | L 5-9 | 38-40 | 2 | 40,822 | Scott Schoeneweis | Jamie Moyer | Jamie Moyer | Scott Schoeneweis | | 337 | 338 | -1 |
| 2001-06-30 | vs SEA | 79 | L 3-5 | 38-41 | 2 | 27,784 | Ramon Ortiz | Denny Stark | Denny Stark | Ramon Ortiz | Kazuhiro Sasaki | 340 | 343 | -3 |
| 2001-07-01 | vs SEA | 80 | L 0-5 | 38-42 | 2 | 28,887 | Matt Wise | Freddy Garcia | Freddy Garcia | Matt Wise | | 340 | 348 | -8 |
| 2001-07-02 | @ OAK | 81 | L 0-1 | 38-43 | 3 | 11,222 | Jarrod Washburn | Tim Hudson | Jeff Tam | Shigetoshi Hasegawa | | 340 | 349 | -9 |
| 2001-07-03 | @ OAK | 82 | L 2-5 | 38-44 | 3 | 51,838 | Pat Rapp | Barry Zito | Barry Zito | Pat Rapp | Jason Isringhausen | 342 | 354 | -12 |
| 2001-07-04 | @ OAK | 83 | L 0-2 | 38-45 | 3 | 29,045 | Scott Schoeneweis | Cory Lidle | Cory Lidle | Scott Schoeneweis | Jim Mecir | 342 | 356 | -14 |
| 2001-07-05 | @ OAK | 84 | W 5-2 | 39-45 | 3 | 12,719 | Ismael Valdez | Gil Heredia | Ismael Valdez | Gil Heredia | Troy Percival | 347 | 358 | -11 |
| 2001-07-06 | @ COL | 85 | W 6-5 | 40-45 | 3 | 48,576 | Ramon Ortiz | Mike Hampton | Ramon Ortiz | Mike Hampton | Troy Percival | 353 | 363 | -10 |
| 2001-07-07 | @ COL | 86 | W 10-3 | 41-45 | 3 | 47,517 | Jarrod Washburn | Denny Neagle | Jarrod Washburn | Mac Suzuki | | 363 | 366 | -3 |
| 2001-07-08 | @ COL | 87 | W 11-3 | 42-45 | 3 | 37,577 | Pat Rapp | Shawn Chacon | Pat Rapp | Shawn Chacon | Lou Pote | 374 | 369 | 5 |
| 2001-07-12 | vs ARI | 88 | W 4-1 | 43-45 | 3 | 18,724 | Scott Schoeneweis | Brian Anderson | Scott Schoeneweis | Brian Anderson | Troy Percival | 378 | 370 | 8 |
| 2001-07-13 | vs ARI | 89 | L 2-6 | 43-46 | 3 | 32,777 | Ismael Valdez | Curt Schilling | Curt Schilling | Ismael Valdez | | 380 | 376 | 4 |
| 2001-07-14 | vs ARI | 90 | L 5-7 | 43-47 | 3 | 30,044 | Jarrod Washburn | Randy Johnson | Bret Prinz | Troy Percival | Byung-Hyun Kim | 385 | 383 | 2 |
| 2001-07-15 | vs SDN | 91 | L 1-5 | 43-48 | 3 | 31,536 | Ramon Ortiz | Brian Lawrence | Brian Lawrence | Ramon Ortiz | | 386 | 388 | -2 |
| 2001-07-16 | vs SDN | 92 | W 7-5 | 44-48 | 3 | 19,456 | Pat Rapp | Brian Tollberg | Ben Weber | Brian Tollberg | Troy Percival | 393 | 393 | 0 |
| 2001-07-17 | vs SDN | 93 | W 8-7 | 45-48 | 3 | 30,181 | Scott Schoeneweis | Bobby Jones | Al Levine | Tom Davey | | 401 | 400 | 1 |
| 2001-07-18 | @ TBA | 94 | W 2-1 | 46-48 | 3 | 12,344 | Ismael Valdez | Joe Kennedy | Ismael Valdez | Joe Kennedy | Troy Percival | 403 | 401 | 2 |
| 2001-07-19 | @ TBA | 95 | W 2-1 | 47-48 | 3 | 19,960 | Jarrod Washburn | Bryan Rekar | Jarrod Washburn | Jeff Wallace | Troy Percival | 405 | 402 | 3 |
| 2001-07-21 | @ BAL | 96 | W 6-5 | 48-48 | 3 | 47,234 | Ramon Ortiz | Josh Towers | Shigetoshi Hasegawa | Alan Mills | | 411 | 407 | 4 |
| 2001-07-22 | @ BAL | 97 | W 9-4 | 49-49 | 3 | 40,543 | Scott Schoeneweis | Willis Roberts | Ben Weber | Willis Roberts | Lou Pote | 420 | 411 | 9 |
| 2001-07-22 | @ BAL | 98 | L 1-5 | 49-49 | 3 | 38,423 | Pat Rapp | Jason Johnson | Jason Johnson | Toby Borland | Buddy Groom | 421 | 416 | 5 |
| 2001-07-23 | @ BAL | 99 | W 9-4 | 50-49 | 3 | 40,880 | Ismael Valdez | Jose Mercedes | Ismael Valdez | Jose Mercedes | | 430 | 420 | 10 |
| 2001-07-24 | vs TBA | 100 | W 9-6 | 51-49 | 3 | 16,131 | Jarrod Washburn | Joe Kennedy | Jarrod Washburn | Joe Kennedy | Al Levine | 439 | 426 | 13 |
| 2001-07-25 | vs TBA | 101 | L 1-3 | 51-50 | 3 | 15,718 | Matt Wise | Paul Wilson | Paul Wilson | Matt Wise | Esteban Yan | 440 | 429 | 11 |
| 2001-07-26 | vs TBA | 102 | W 5-3 | 52-50 | 3 | 15,782 | Ramon Ortiz | Ryan Rupe | Ramon Ortiz | Ryan Rupe | Troy Percival | 445 | 432 | 13 |
| 2001-07-27 | vs BAL | 103 | L 3-4 | 52-51 | 3 | 39,616 | Scott Schoeneweis | Jason Johnson | Mike Trombley | Al Levine | Buddy Groom | 448 | 436 | 12 |
| 2001-07-28 | vs BAL | 104 | W 6-4 | 53-51 | 3 | 39,261 | Pat Rapp | Willis Roberts | Ben Weber | Ryan Kohlmeier | Troy Percival | 454 | 440 | 14 |
| 2001-07-29 | vs BAL | 105 | L 0-1 | 53-52 | 3 | 35,053 | Ismael Valdez | Jose Mercedes | Jose Mercedes | Ismael Valdez | Buddy Groom | 454 | 441 | 13 |
| 2001-07-31 | @ BOS | 106 | W 4-3 | 54-52 | 3 | 33,909 | Ramon Ortiz | Rolando Arrojo | Ramon Ortiz | Rich Garces | Troy Percival | 458 | 444 | 14 |
| 2001-08-01 | @ BOS | 107 | W 4-2 | 55-52 | 3 | 33,551 | Scott Schoeneweis | Hideo Nomo | Scott Schoeneweis | Hideo Nomo | Al Levine | 462 | 446 | 16 |
| 2001-08-02 | @ BOS | 108 | W 13-4 | 56-52 | 3 | 33,611 | Pat Rapp | Bret Saberhagen | Pat Rapp | Bret Saberhagen | | 475 | 450 | 25 |
| 2001-08-03 | @ NYA | 109 | L 2-4 | 56-53 | 3 | 40,490 | Jarrod Washburn | Andy Pettitte | Andy Pettitte | Jarrod Washburn | Mariano Rivera | 477 | 454 | 23 |
| 2001-08-04 | @ NYA | 110 | L 4-5 | 56-54 | 3 | 46,416 | Ismael Valdez | Roger Clemens | Mariano Rivera | Al Levine | | 481 | 459 | 22 |
| 2001-08-05 | @ NYA | 111 | W 4-3 | 57-54 | 3 | 48,978 | Ramon Ortiz | Ted Lilly | Ramon Ortiz | Ramiro Mendoza | Troy Percival | 485 | 462 | 23 |
| 2001-08-06 | @ NYA | 112 | W 3-1 | 58-54 | 3 | 40,232 | Lou Pote | Sterling Hitchcock | Lou Pote | Sterling Hitchcock | Troy Percival | 488 | 463 | 25 |
| 2001-08-07 | vs CHA | 113 | W 9-3 | 59-54 | 3 | 18,498 | Pat Rapp | Kip Wells | Pat Rapp | Kip Wells | | 497 | 466 | 31 |
| 2001-08-08 | vs CHA | 114 | L 1-15 | 59-55 | 3 | 18,864 | Jarrod Washburn | Mark Buehrle | Mark Buehrle | Jarrod Washburn | | 498 | 481 | 17 |
| 2001-08-09 | vs CHA | 115 | W 3-2 | 60-55 | 3 | 17,896 | Ismael Valdez | Sean Lowe | Ismael Valdez | Sean Lowe | Troy Percival | 501 | 483 | 18 |
| 2001-08-10 | vs TOR | 116 | W 8-7 | 61-55 | 3 | 30,484 | Scott Schoeneweis | Brandon Lyon | Scott Schoeneweis | Brandon Lyon | Troy Percival | 509 | 490 | 19 |
| 2001-08-11 | vs TOR | 117 | L 6-7 | 61-56 | 3 | 27,927 | Ramon Ortiz | Esteban Loaiza | Dan Plesac | Al Levine | Billy Koch | 515 | 497 | 18 |
| 2001-08-12 | vs TOR | 118 | W 6-5 | 62-56 | 3 | 19,129 | Pat Rapp | Roy Halladay | Al Levine | Dan Plesac | Troy Percival | 521 | 502 | 19 |
| 2001-08-14 | @ DET | 119 | W 7-1 | 63-56 | 3 | 24,082 | Jarrod Washburn | Nate Cornejo | Jarrod Washburn | Nate Cornejo | | 528 | 503 | 25 |
| 2001-08-15 | @ DET | 120 | L 1-5 | 63-57 | 3 | 20,853 | Ismael Valdez | Steve Sparks | Matt Perisho | Mike Holtz | | 529 | 508 | 21 |
| 2001-08-16 | @ DET | 121 | W 4-2 | 64-57 | 3 | 22,141 | Scott Schoeneweis | Jeff Weaver | Scott Schoeneweis | Jeff Weaver | Troy Percival | 533 | 510 | 23 |
| 2001-08-17 | @ CLE | 122 | W 7-2 | 65-57 | 3 | 42,528 | Ramon Ortiz | Charles Nagy | Ramon Ortiz | Charles Nagy | | 540 | 512 | 28 |
| 2001-08-18 | @ CLE | 123 | L 2-4 | 65-58 | 3 | 42,610 | Pat Rapp | CC Sabathia | CC Sabathia | Pat Rapp | Bob Wickman | 542 | 516 | 26 |
| 2001-08-19 | @ CLE | 124 | W 4-1 | 66-58 | 3 | 42,510 | Jarrod Washburn | Bartolo Colon | Jarrod Washburn | Bartolo Colon | Troy Percival | 546 | 517 | 29 |
| 2001-08-20 | vs BOS | 125 | L 1-6 | 66-59 | 3 | 22,891 | Ismael Valdez | Frank Castillo | Frank Castillo | Ismael Valdez | | 547 | 523 | 24 |
| 2001-08-21 | vs BOS | 126 | L 5-8 | 66-60 | 3 | 24,402 | Scott Schoeneweis | David Cone | David Cone | Scott Schoeneweis | Ugueth Urbina | 552 | 531 | 21 |
| 2001-08-22 | vs BOS | 127 | W 4-2 | 67-60 | 3 | 23,017 | Ramon Ortiz | Tim Wakefield | Al Levine | Tim Wakefield | Troy Percival | 556 | 533 | 23 |
| 2001-08-23 | vs BOS | 128 | L 6-7 | 67-61 | 3 | 27,377 | Pat Rapp | Casey Fossum | Rich Garces | Ben Weber | Ugueth Urbina | 562 | 540 | 22 |
| 2001-08-24 | vs NYA | 129 | W 6-2 | 68-61 | 3 | 43,489 | Jarrod Washburn | Andy Pettitte | Shigetoshi Hasegawa | Andy Pettitte | | 568 | 542 | 26 |
| 2001-08-25 | vs NYA | 130 | L 5-7 | 68-62 | 3 | 43,398 | Ismael Valdez | Roger Clemens | Roger Clemens | Ismael Valdez | Mariano Rivera | 573 | 549 | 24 |
| 2001-08-26 | vs NYA | 131 | W 7-6 | 69-62 | 3 | 41,660 | Scott Schoeneweis | Orlando Hernandez | Troy Percival | Mike Stanton | | 580 | 555 | 25 |
| 2001-08-28 | @ KCA | 132 | L 4-10 | 69-63 | 3 | 11,479 | Ramon Ortiz | Chris George | Chris George | Ramon Ortiz | | 584 | 565 | 19 |
| 2001-08-29 | @ KCA | 133 | L 3-6 | 69-64 | 3 | 11,190 | Pat Rapp | Jeff Suppan | Jeff Suppan | Pat Rapp | Roberto Hernandez | 587 | 571 | 16 |
| 2001-08-30 | @ KCA | 134 | L 1-2 | 69-65 | 3 | 12,159 | Jarrod Washburn | Chad Durbin | Jason Grimsley | Al Levine | | 588 | 573 | 15 |
| 2001-08-31 | @ MIN | 135 | L 1-4 | 69-66 | 3 | 12,070 | Ismael Valdez | Brad Radke | Brad Radke | Ismael Valdez | Todd Jones | 589 | 577 | 12 |
| 2001-09-01 | @ MIN | 136 | W 11-9 | 70-66 | 3 | 18,001 | Scott Schoeneweis | Kyle Lohse | Al Levine | LaTroy Hawkins | Troy Percival | 600 | 586 | 14 |
| 2001-09-02 | @ MIN | 137 | L 4-5 | 70-67 | 3 | 17,352 | Ramon Ortiz | Rick Reed | Eddie Guardado | Al Levine | | 604 | 591 | 13 |
| 2001-09-04 | vs KCA | 138 | L 1-4 | 70-68 | 3 | 13,950 | Jarrod Washburn | Jeff Suppan | Jeff Suppan | Jarrod Washburn | | 605 | 595 | 10 |
| 2001-09-05 | vs KCA | 139 | W 4-1 | 71-68 | 3 | 13,998 | Ismael Valdez | Chad Durbin | Ismael Valdez | Chad Durbin | Troy Percival | 609 | 596 | 13 |
| 2001-09-06 | vs KCA | 140 | W 7-6 | 72-68 | 3 | 13,763 | Scott Schoeneweis | Paul Byrd | Mike Holtz | Roberto Hernandez | | 616 | 602 | 14 |
| 2001-09-07 | vs MIN | 141 | W 7-3 | 73-68 | 3 | 23,377 | Ramon Ortiz | Kyle Lohse | Ramon Ortiz | Kyle Lohse | | 623 | 605 | 18 |
| 2001-09-08 | vs MIN | 142 | L 4-6 | 73-69 | 3 | 25,913 | Pat Rapp | Rick Reed | Rick Reed | Pat Rapp | Eddie Guardado | 627 | 611 | 16 |
| 2001-09-09 | vs MIN | 143 | L 0-3 | 73-70 | 3 | 18,157 | Jarrod Washburn | Eric Milton | Eric Milton | Jarrod Washburn | Bob Wells | 627 | 614 | 13 |
| 2001-09-10 | vs SEA | 144 | L 1-5 | 73-71 | 3 | 20,311 | Ismael Valdez | Freddy Garcia | Freddy Garcia | Ismael Valdez | | 628 | 619 | 9 |
| 2001-09-18 | @ SEA | 145 | L 0-4 | 73-72 | 3 | 45,294 | Ramon Ortiz | Freddy Garcia | Freddy Garcia | Ramon Ortiz | | 628 | 623 | 5 |
| 2001-09-19 | @ SEA | 146 | L 0-5 | 73-73 | 3 | 45,459 | Scott Schoeneweis | Jamie Moyer | Jamie Moyer | Scott Schoeneweis | | 628 | 628 | 0 |
| 2001-09-20 | @ SEA | 147 | W 6-3 | 74-73 | 3 | 44,768 | Jarrod Washburn | Aaron Sele | Shigetoshi Hasegawa | John Halama | Troy Percival | 634 | 631 | 3 |
| 2001-09-21 | @ TEX | 148 | L 8-9 | 74-74 | 3 | 37,291 | Ismael Valdez | Rob Bell | Rob Bell | Ismael Valdez | Jeff Zimmerman | 642 | 640 | 2 |
| 2001-09-22 | @ TEX | 149 | L 4-5 | 74-75 | 3 | 38,781 | Matt Wise | Aaron Myette | Pat Mahomes | Mike Holtz | | 646 | 645 | 1 |
| 2001-09-23 | @ TEX | 150 | L 2-5 | 74-76 | 3 | 34,542 | Ramon Ortiz | Rick Helling | Rick Helling | Ramon Ortiz | Jeff Zimmerman | 648 | 650 | -2 |
| 2001-09-25 | @ OAK | 151 | L 3-9 | 74-77 | 3 | 14,172 | Scott Schoeneweis | Tim Hudson | Tim Hudson | Shigetoshi Hasegawa | | 651 | 659 | -8 |
| 2001-09-26 | @ OAK | 152 | L 1-3 | 74-78 | 3 | 27,635 | Jarrod Washburn | Barry Zito | Barry Zito | Jarrod Washburn | Jason Isringhausen | 652 | 662 | -10 |
| 2001-09-27 | @ OAK | 153 | L 2-6 | 74-79 | 3 | 17,167 | Matt Wise | Cory Lidle | Cory Lidle | Matt Wise | | 654 | 668 | -14 |
| 2001-09-28 | vs TEX | 154 | L 2-11 | 74-80 | 3 | 26,128 | Ismael Valdez | Aaron Myette | Aaron Myette | Ismael Valdez | | 656 | 679 | -23 |
| 2001-09-29 | vs TEX | 155 | W 13-2 | 75-80 | 3 | 26,439 | Ramon Ortiz | Rick Helling | Ramon Ortiz | Rick Helling | | 669 | 681 | -12 |
| 2001-09-30 | vs TEX | 156 | L 6-8 | 75-81 | 3 | 17,507 | Scott Schoeneweis | Doug Davis | Doug Davis | Shigetoshi Hasegawa | Jeff Zimmerman | 675 | 689 | -14 |
| 2001-10-02 | vs SEA | 157 | L 5-14 | 75-82 | 3 | 18,600 | Jarrod Washburn | Paul Abbott | Paul Abbott | Jarrod Washburn | | 680 | 703 | -23 |
| 2001-10-03 | vs SEA | 158 | L 3-4 | 75-83 | 3 | 18,503 | Matt Wise | Freddy Garcia | Norm Charlton | Al Levine | Kazuhiro Sasaki | 683 | 707 | -24 |
| 2001-10-04 | vs OAK | 159 | L 1-5 | 75-84 | 3 | 14,215 | Ismael Valdez | Mark Mulder | Mark Mulder | Ismael Valdez | | 684 | 712 | -28 |
| 2001-10-05 | vs OAK | 160 | L 2-6 | 75-85 | 3 | 26,343 | Ramon Ortiz | Tim Hudson | Tim Hudson | Ramon Ortiz | | 686 | 718 | -32 |
| 2001-10-06 | vs OAK | 161 | L 3-6 | 75-86 | 3 | 26,276 | Scott Schoeneweis | Erik Hiljus | Mike Magnante | Scott Schoeneweis | Jason Isringhausen | 689 | 724 | -35 |
| 2001-10-07 | vs OAK | 162 | L 2-6 | 75-87 | 3 | 18,682 | Brian Cooper | Barry Zito | Barry Zito | Brian Cooper | | 691 | 730 | -39 |