| 2000-04-03 | vs MIL | 1 | W 3-3 | 1-0 | 1 | 55,596 | Pete Harnisch | Steve Woodard | | | | 3 | 3 | 0 |
| 2000-04-04 | vs MIL | 2 | L 1-5 | 1-1 | 3 | 16,761 | Denny Neagle | Valerio de los Santos | Jim Bruske | Scott Williamson | | 4 | 8 | -4 |
| 2000-04-05 | vs MIL | 3 | L 5-8 | 1-2 | 4 | 23,059 | Steve Parris | Jimmy Haynes | Jimmy Haynes | Steve Parris | Bob Wickman | 9 | 16 | -7 |
| 2000-04-06 | vs MIL | 4 | W 5-1 | 2-2 | 3 | 20,909 | Ron Villone | Jaime Navarro | Ron Villone | Jaime Navarro | | 14 | 17 | -3 |
| 2000-04-07 | vs CHN | 5 | L 6-10 | 2-3 | 5 | 36,383 | Pete Harnisch | Andrew Lorraine | Andrew Lorraine | Pete Harnisch | Rick Aguilera | 20 | 27 | -7 |
| 2000-04-08 | vs CHN | 6 | W 4-3 | 3-3 | 3 | 37,151 | Rob Bell | Kevin Tapani | Danny Graves | Mark Guthrie | | 24 | 30 | -6 |
| 2000-04-09 | vs CHN | 7 | W 8-7 | 4-3 | 2 | 37,798 | Denny Neagle | Scott Downs | Danny Graves | Matt Karchner | | 32 | 37 | -5 |
| 2000-04-10 | @ COL | 8 | L 5-7 | 4-4 | 2 | 48,094 | Steve Parris | Rolando Arrojo | Rolando Arrojo | Steve Parris | Stan Belinda | 37 | 44 | -7 |
| 2000-04-11 | @ COL | 9 | W 10-3 | 5-4 | 2 | 40,488 | Ron Villone | Brian Bohanon | Ron Villone | Brian Bohanon | | 47 | 47 | 0 |
| 2000-04-12 | @ COL | 10 | L 5-7 | 5-5 | 2 | 38,339 | Pete Harnisch | Masato Yoshii | Jose Jimenez | Dennys Reyes | Julian Tavarez | 52 | 54 | -2 |
| 2000-04-14 | @ LAN | 11 | L 1-8 | 5-6 | 3 | 53,223 | Rob Bell | Orel Hershiser | Orel Hershiser | Rob Bell | | 53 | 62 | -9 |
| 2000-04-15 | @ LAN | 12 | W 5-4 | 6-6 | 2 | 51,179 | Denny Neagle | Eric Gagne | Scott Williamson | Alan Mills | Danny Graves | 58 | 66 | -8 |
| 2000-04-16 | @ LAN | 13 | W 5-3 | 7-6 | 2 | 52,594 | Steve Parris | Chan Ho Park | Steve Parris | Chan Ho Park | Danny Graves | 63 | 69 | -6 |
| 2000-04-18 | vs SFN | 14 | L 9-13 | 7-7 | 2 | 25,888 | Ron Villone | Joe Nathan | Kirk Rueter | Scott Williamson | | 72 | 82 | -10 |
| 2000-04-19 | vs SFN | 15 | W 5-4 | 8-7 | 2 | 22,795 | Rob Bell | Shawn Estes | Rob Bell | Shawn Estes | Danny Graves | 77 | 86 | -9 |
| 2000-04-20 | vs SFN | 16 | W 11-1 | 9-7 | 2 | 27,003 | Denny Neagle | Livan Hernandez | Denny Neagle | Livan Hernandez | | 88 | 87 | 1 |
| 2000-04-21 | vs LAN | 17 | L 2-9 | 9-8 | 2 | 34,458 | Steve Parris | Eric Gagne | Matt Herges | Steve Parris | Terry Adams | 90 | 96 | -6 |
| 2000-04-22 | vs LAN | 18 | L 2-16 | 9-9 | 2 | 35,557 | Pete Harnisch | Chan Ho Park | Chan Ho Park | Pete Harnisch | Alan Mills | 92 | 112 | -20 |
| 2000-04-23 | vs LAN | 19 | L 3-11 | 9-10 | 2 | 29,124 | Ron Villone | Carlos Perez | Carlos Perez | Ron Villone | | 95 | 123 | -28 |
| 2000-04-25 | @ NYN | 20 | L 5-6 | 9-11 | 2 | 27,153 | Rob Bell | Al Leiter | Turk Wendell | Scott Sullivan | Armando Benitez | 100 | 129 | -29 |
| 2000-04-26 | @ NYN | 21 | W 12-1 | 10-11 | 2 | 33,371 | Denny Neagle | Dennis Springer | Denny Neagle | Dennis Springer | | 112 | 130 | -18 |
| 2000-04-27 | @ NYN | 22 | W 2-1 | 11-11 | 2 | 50,971 | Steve Parris | Glendon Rusch | Danny Graves | Armando Benitez | Scott Sullivan | 114 | 131 | -17 |
| 2000-04-28 | @ PIT | 23 | L 1-2 | 11-12 | 2 | 25,557 | Pete Harnisch | Kris Benson | Kris Benson | Pete Harnisch | Mike Williams | 115 | 133 | -18 |
| 2000-04-29 | @ PIT | 24 | W 6-5 | 12-12 | 2 | 28,731 | Ron Villone | Francisco Cordova | Scott Williamson | Jason Christiansen | Danny Graves | 121 | 138 | -17 |
| 2000-04-30 | @ PIT | 25 | W 6-2 | 13-12 | 2 | 29,728 | Rob Bell | Todd Ritchie | Rob Bell | Todd Ritchie | Scott Williamson | 127 | 140 | -13 |
| 2000-05-02 | @ PHI | 26 | W 7-0 | 14-12 | 2 | 23,234 | Denny Neagle | Andy Ashby | Denny Neagle | Andy Ashby | Scott Sullivan | 134 | 140 | -6 |
| 2000-05-03 | @ PHI | 27 | L 2-5 | 14-13 | 2 | 23,260 | Steve Parris | Paul Byrd | Paul Byrd | Steve Parris | | 136 | 145 | -9 |
| 2000-05-04 | @ PHI | 28 | L 1-14 | 14-14 | 2 | 27,564 | Pete Harnisch | Robert Person | Robert Person | Pete Harnisch | | 137 | 159 | -22 |
| 2000-05-05 | vs SLN | 29 | W 3-2 | 15-14 | 2 | 42,126 | Ron Villone | Andy Benes | Ron Villone | Andy Benes | Scott Williamson | 140 | 161 | -21 |
| 2000-05-06 | vs SLN | 30 | L 1-3 | 15-15 | 2 | 46,550 | Rob Bell | Darryl Kile | Darryl Kile | Rob Bell | Dave Veres | 141 | 164 | -23 |
| 2000-05-07 | vs SLN | 31 | W 9-7 | 16-15 | 2 | 42,221 | Denny Neagle | Rick Ankiel | Denny Neagle | Darren Holmes | Scott Williamson | 150 | 171 | -21 |
| 2000-05-09 | vs SDN | 32 | W 2-0 | 17-15 | 2 | 22,435 | Steve Parris | Brian Meadows | Steve Parris | Brian Meadows | Danny Graves | 152 | 171 | -19 |
| 2000-05-10 | vs SDN | 33 | W 5-1 | 18-15 | 2 | 27,797 | Ron Villone | Sterling Hitchcock | Ron Villone | Sterling Hitchcock | Scott Williamson | 157 | 172 | -15 |
| 2000-05-11 | vs SDN | 34 | W 11-9 | 19-15 | 2 | 24,825 | Rob Bell | Rodrigo Lopez | Danny Graves | Matt Whisenant | | 168 | 181 | -13 |
| 2000-05-12 | @ HOU | 35 | W 7-3 | 20-15 | 1 | 42,043 | Denny Neagle | Octavio Dotel | Danny Graves | Mike Maddux | | 175 | 184 | -9 |
| 2000-05-13 | @ HOU | 36 | W 8-7 | 21-15 | 1 | 42,280 | Osvaldo Fernandez | Chris Holt | Dennys Reyes | Billy Wagner | Scott Williamson | 183 | 191 | -8 |
| 2000-05-14 | @ HOU | 37 | L 3-10 | 21-16 | 1 | 41,882 | Steve Parris | Scott Elarton | Scott Elarton | Steve Parris | | 186 | 201 | -15 |
| 2000-05-15 | @ HOU | 38 | W 4-3 | 22-16 | 1 | 41,710 | Ron Villone | Jose Lima | Ron Villone | Jose Lima | Danny Graves | 190 | 204 | -14 |
| 2000-05-16 | vs PIT | 39 | W 6-2 | 23-16 | 1 | 26,271 | Rob Bell | Todd Ritchie | Rob Bell | Todd Ritchie | | 196 | 206 | -10 |
| 2000-05-17 | vs PIT | 40 | L 6-9 | 23-17 | 1 | 23,193 | Denny Neagle | Jimmy Anderson | Jose Silva | Scott Sullivan | | 202 | 215 | -13 |
| 2000-05-18 | vs PIT | 41 | W 4-3 | 24-17 | 1 | 26,252 | Osvaldo Fernandez | Jason Schmidt | Danny Graves | Mike Garcia | | 206 | 218 | -12 |
| 2000-05-19 | @ CHN | 42 | L 1-4 | 24-18 | 1 | 37,199 | Steve Parris | Ismael Valdez | Ismael Valdez | Steve Parris | Todd Van Poppel | 207 | 222 | -15 |
| 2000-05-20 | @ CHN | 43 | W 5-3 | 25-18 | 1 | 39,101 | Ron Villone | Jon Lieber | Ron Villone | Jon Lieber | Danny Graves | 212 | 225 | -13 |
| 2000-05-21 | @ CHN | 44 | L 2-4 | 25-19 | 2 | 39,148 | Rob Bell | Kevin Tapani | Kevin Tapani | Rob Bell | Felix Heredia | 214 | 229 | -15 |
| 2000-05-22 | @ LAN | 45 | L 3-4 | 25-20 | 2 | 31,000 | Denny Neagle | Darren Dreifort | Matt Herges | Manny Aybar | | 217 | 233 | -16 |
| 2000-05-23 | @ LAN | 46 | W 3-1 | 26-20 | 2 | 39,411 | Osvaldo Fernandez | Eric Gagne | Osvaldo Fernandez | Eric Gagne | Danny Graves | 220 | 234 | -14 |
| 2000-05-24 | @ LAN | 47 | W 10-3 | 27-20 | 2 | 31,740 | Steve Parris | Chan Ho Park | Scott Sullivan | Chan Ho Park | | 230 | 237 | -7 |
| 2000-05-26 | vs FLO | 48 | W 3-2 | 28-20 | 2 | 33,018 | Ron Villone | Jesus Sanchez | Danny Graves | Dan Miceli | | 233 | 239 | -6 |
| 2000-05-27 | vs FLO | 49 | L 6-8 | 28-21 | 2 | 38,744 | Rob Bell | Brad Penny | Antonio Alfonseca | Scott Williamson | | 239 | 247 | -8 |
| 2000-05-28 | vs FLO | 50 | L 1-3 | 28-22 | 2 | 36,754 | Denny Neagle | Ryan Dempster | Ryan Dempster | Scott Sullivan | Antonio Alfonseca | 240 | 250 | -10 |
| 2000-05-30 | vs MON | 51 | W 4-2 | 29-22 | 2 | 20,250 | Osvaldo Fernandez | Tony Armas | Osvaldo Fernandez | Tony Armas | Scott Williamson | 244 | 252 | -8 |
| 2000-05-31 | vs MON | 52 | L 4-10 | 29-23 | 2 | 21,207 | Steve Parris | Mike Johnson | Mike Johnson | Steve Parris | | 248 | 262 | -14 |
| 2000-06-01 | vs MON | 53 | L 7-9 | 29-24 | 2 | 23,099 | Ron Villone | Javier Vazquez | Javier Vazquez | Ron Villone | Steve Kline | 255 | 271 | -16 |
| 2000-06-02 | vs MIN | 54 | W 4-3 | 30-24 | 2 | 29,269 | Rob Bell | Joe Mays | Rob Bell | Joe Mays | Danny Graves | 259 | 274 | -15 |
| 2000-06-03 | vs MIN | 55 | W 9-3 | 31-24 | 1 | 45,617 | Denny Neagle | Sean Bergman | Denny Neagle | Sean Bergman | | 268 | 277 | -9 |
| 2000-06-04 | vs MIN | 56 | W 3-2 | 32-24 | 1 | 40,169 | Osvaldo Fernandez | Mark Redman | Danny Graves | LaTroy Hawkins | | 271 | 279 | -8 |
| 2000-06-05 | vs CHA | 57 | L 3-4 | 32-25 | 1 | 26,624 | Steve Parris | James Baldwin | James Baldwin | Steve Parris | Keith Foulke | 274 | 283 | -9 |
| 2000-06-06 | vs CHA | 58 | L 12-17 | 32-26 | 1 | 28,908 | Ron Villone | Cal Eldred | Cal Eldred | Ron Villone | | 286 | 300 | -14 |
| 2000-06-07 | vs CHA | 59 | L 4-6 | 32-27 | 2 | 31,023 | Rob Bell | Jim Parque | Jim Parque | Rob Bell | Keith Foulke | 290 | 306 | -16 |
| 2000-06-09 | @ CLE | 60 | L 4-7 | 32-28 | 2 | 43,105 | Denny Neagle | Jim Brower | Jim Brower | Denny Neagle | Steve Karsay | 294 | 313 | -19 |
| 2000-06-10 | @ CLE | 61 | L 5-6 | 32-29 | 2 | 43,084 | Steve Parris | Dave Burba | Dave Burba | Steve Parris | Steve Karsay | 299 | 319 | -20 |
| 2000-06-11 | @ CLE | 62 | W 7-5 | 33-29 | 2 | 43,036 | Ron Villone | Chuck Finley | Manny Aybar | Scott Kamieniecki | | 306 | 324 | -18 |
| 2000-06-12 | @ SFN | 63 | L 3-10 | 33-30 | 2 | 40,930 | Rob Bell | Joe Nathan | Joe Nathan | Rob Bell | | 309 | 334 | -25 |
| 2000-06-13 | @ SFN | 64 | L 2-3 | 33-31 | 2 | 40,930 | Osvaldo Fernandez | Russ Ortiz | Robb Nen | Danny Graves | | 311 | 337 | -26 |
| 2000-06-14 | @ SFN | 65 | L 2-6 | 33-32 | 2 | 40,930 | Denny Neagle | Kirk Rueter | Kirk Rueter | Denny Neagle | Felix Rodriguez | 313 | 343 | -30 |
| 2000-06-16 | @ SDN | 66 | L 5-8 | 33-33 | 2 | 60,760 | Steve Parris | Brian Meadows | Carlos Reyes | Steve Parris | Trevor Hoffman | 318 | 351 | -33 |
| 2000-06-17 | @ SDN | 67 | L 1-3 | 33-34 | 2 | 40,730 | Ron Villone | Adam Eaton | Kevin Walker | Ron Villone | Trevor Hoffman | 319 | 354 | -35 |
| 2000-06-18 | @ SDN | 68 | L 7-8 | 33-35 | 2 | 39,823 | Rob Bell | Matt Clement | Matt Clement | Rob Bell | Trevor Hoffman | 326 | 362 | -36 |
| 2000-06-20 | vs COL | 69 | W 3-2 | 34-35 | 2 | 24,060 | Osvaldo Fernandez | Pedro Astacio | Danny Graves | Pedro Astacio | | 329 | 364 | -35 |
| 2000-06-21 | vs COL | 70 | L 4-6 | 34-36 | 2 | 23,580 | Denny Neagle | Rolando Arrojo | Julian Tavarez | Scott Williamson | Jose Jimenez | 333 | 370 | -37 |
| 2000-06-22 | vs COL | 71 | W 5-3 | 35-36 | 2 | 28,531 | Steve Parris | Kevin Jarvis | Steve Parris | Kevin Jarvis | Danny Graves | 338 | 373 | -35 |
| 2000-06-23 | vs SDN | 72 | L 7-10 | 35-37 | 2 | 31,746 | Rob Bell | Adam Eaton | Trevor Hoffman | Scott Williamson | Carlos Reyes | 345 | 383 | -38 |
| 2000-06-24 | vs SDN | 73 | W 11-5 | 36-37 | 2 | 43,033 | Ron Villone | Matt Clement | Ron Villone | Matt Clement | Elmer Dessens | 356 | 388 | -32 |
| 2000-06-25 | vs SDN | 74 | L 4-5 | 36-38 | 2 | 33,247 | Osvaldo Fernandez | Brian Tollberg | Brian Tollberg | Osvaldo Fernandez | Trevor Hoffman | 360 | 393 | -33 |
| 2000-06-26 | vs SLN | 75 | W 3-2 | 37-38 | 2 | 32,850 | Denny Neagle | Garrett Stephenson | Denny Neagle | Garrett Stephenson | Danny Graves | 363 | 395 | -32 |
| 2000-06-27 | vs SLN | 76 | L 3-4 | 37-39 | 2 | 33,946 | Steve Parris | Darryl Kile | Darryl Kile | Steve Parris | Dave Veres | 366 | 399 | -33 |
| 2000-06-28 | vs SLN | 77 | W 7-3 | 38-39 | 2 | 37,861 | Elmer Dessens | Pat Hentgen | Dennys Reyes | Alan Benes | | 373 | 402 | -29 |
| 2000-06-29 | vs SLN | 78 | L 3-12 | 38-40 | 2 | 45,771 | Ron Villone | Andy Benes | Andy Benes | Ron Villone | | 376 | 414 | -38 |
| 2000-06-30 | @ ARI | 79 | W 5-4 | 39-40 | 2 | 38,197 | Pete Harnisch | Mike Morgan | Pete Harnisch | Mike Morgan | Danny Graves | 381 | 418 | -37 |
| 2000-07-01 | @ ARI | 80 | L 6-9 | 39-41 | 2 | 39,385 | Osvaldo Fernandez | Armando Reynoso | Russ Springer | Osvaldo Fernandez | Byung-Hyun Kim | 387 | 427 | -40 |
| 2000-07-02 | @ ARI | 81 | W 14-2 | 40-41 | 2 | 39,841 | Denny Neagle | Omar Daal | Denny Neagle | Omar Daal | | 401 | 429 | -28 |
| 2000-07-03 | @ ARI | 82 | W 3-2 | 41-41 | 2 | 38,287 | Steve Parris | Brian Anderson | Steve Parris | Brian Anderson | Danny Graves | 404 | 431 | -27 |
| 2000-07-04 | @ SLN | 83 | L 3-14 | 41-42 | 2 | 46,022 | Ron Villone | Andy Benes | Andy Benes | Ron Villone | | 407 | 445 | -38 |
| 2000-07-05 | @ SLN | 84 | L 3-4 | 41-43 | 2 | 45,269 | Pete Harnisch | Pat Hentgen | Pat Hentgen | Pete Harnisch | Dave Veres | 410 | 449 | -39 |
| 2000-07-06 | @ SLN | 85 | W 12-6 | 42-43 | 2 | 43,287 | Osvaldo Fernandez | Rick Ankiel | Elmer Dessens | Rick Ankiel | | 422 | 455 | -33 |
| 2000-07-07 | vs CLE | 86 | W 2-1 | 43-43 | 2 | 53,509 | Denny Neagle | Chuck Finley | Denny Neagle | Chuck Finley | Danny Graves | 424 | 456 | -32 |
| 2000-07-08 | vs CLE | 87 | W 14-5 | 44-43 | 2 | 54,335 | Steve Parris | Kane Davis | Steve Parris | Kane Davis | | 438 | 461 | -23 |
| 2000-07-09 | vs CLE | 88 | L 3-5 | 44-44 | 2 | 51,181 | Scott Williamson | Bartolo Colon | Bartolo Colon | Scott Williamson | Steve Karsay | 441 | 466 | -25 |
| 2000-07-13 | @ COL | 89 | W 15-6 | 45-44 | 2 | 48,735 | Elmer Dessens | Pedro Astacio | Elmer Dessens | Pedro Astacio | | 456 | 472 | -16 |
| 2000-07-14 | @ COL | 90 | W 9-2 | 46-44 | 2 | 48,471 | Pete Harnisch | Rolando Arrojo | Pete Harnisch | Rolando Arrojo | | 465 | 474 | -9 |
| 2000-07-15 | @ COL | 91 | W 7-4 | 47-44 | 2 | 48,201 | Scott Williamson | Masato Yoshii | Scott Williamson | Masato Yoshii | Danny Graves | 472 | 478 | -6 |
| 2000-07-16 | @ DET | 92 | L 2-6 | 47-45 | 2 | 40,637 | Steve Parris | Jeff Weaver | Jeff Weaver | Steve Parris | | 474 | 484 | -10 |
| 2000-07-17 | @ DET | 93 | L 1-3 | 47-46 | 2 | 35,217 | Larry Luebbers | Dave Mlicki | Dave Mlicki | Larry Luebbers | Todd Jones | 475 | 487 | -12 |
| 2000-07-18 | @ DET | 94 | W 5-4 | 48-46 | 2 | 38,255 | Elmer Dessens | Brian Moehler | Elmer Dessens | Brian Moehler | Danny Graves | 480 | 491 | -11 |
| 2000-07-19 | @ HOU | 95 | W 4-0 | 49-46 | 2 | 41,484 | Pete Harnisch | Chris Holt | Pete Harnisch | Chris Holt | | 484 | 491 | -7 |
| 2000-07-20 | @ HOU | 96 | L 2-6 | 49-47 | 2 | 42,559 | Scott Williamson | Jose Lima | Jose Lima | Scott Williamson | | 486 | 497 | -11 |
| 2000-07-21 | vs ARI | 97 | L 4-5 | 49-48 | 2 | 46,101 | Steve Parris | Mike Morgan | Greg Swindell | Scott Sullivan | Matt Mantei | 490 | 502 | -12 |
| 2000-07-22 | vs ARI | 98 | W 7-3 | 50-48 | 2 | 42,568 | Ron Villone | Geraldo Guzman | Ron Villone | Geraldo Guzman | | 497 | 505 | -8 |
| 2000-07-23 | vs ARI | 99 | W 5-3 | 51-48 | 2 | 34,822 | Elmer Dessens | Brian Anderson | Elmer Dessens | Brian Anderson | Danny Graves | 502 | 508 | -6 |
| 2000-07-24 | vs HOU | 100 | L 5-7 | 51-49 | 2 | 28,741 | Pete Harnisch | Chris Holt | Octavio Dotel | Danny Graves | | 507 | 515 | -8 |
| 2000-07-25 | vs HOU | 101 | L 4-7 | 51-50 | 2 | 33,424 | Scott Williamson | Jose Lima | Marc Valdes | Ron Villone | | 511 | 522 | -11 |
| 2000-07-26 | vs HOU | 102 | L 2-3 | 51-51 | 2 | 32,365 | Steve Parris | Scott Elarton | Scott Elarton | Steve Parris | Octavio Dotel | 513 | 525 | -12 |
| 2000-07-28 | @ MON | 103 | W 8-3 | 52-51 | 2 | 11,547 | Elmer Dessens | Mike Johnson | Elmer Dessens | Mike Johnson | | 521 | 528 | -7 |
| 2000-07-29 | @ MON | 104 | W 4-3 | 53-51 | 2 | 13,577 | Pete Harnisch | Javier Vazquez | Danny Graves | Julio Santana | | 525 | 531 | -6 |
| 2000-07-30 | @ MON | 105 | W 7-4 | 54-51 | 2 | 14,495 | Rob Bell | Dustin Hermanson | Rob Bell | Dustin Hermanson | Danny Graves | 532 | 535 | -3 |
| 2000-07-31 | @ NYN | 106 | W 6-0 | 55-51 | 2 | 42,774 | Scott Williamson | Glendon Rusch | Scott Williamson | Glendon Rusch | Larry Luebbers | 538 | 535 | 3 |
| 2000-08-01 | @ NYN | 107 | L 2-3 | 55-52 | 2 | 39,572 | Steve Parris | Mike Hampton | Mike Hampton | Steve Parris | Armando Benitez | 540 | 538 | 2 |
| 2000-08-02 | @ NYN | 108 | L 1-2 | 55-53 | 2 | 42,111 | Elmer Dessens | Al Leiter | Al Leiter | Elmer Dessens | Armando Benitez | 541 | 540 | 1 |
| 2000-08-04 | vs FLO | 109 | L 1-2 | 55-54 | 2 | 34,849 | Pete Harnisch | Ryan Dempster | Ryan Dempster | Pete Harnisch | Antonio Alfonseca | 542 | 542 | 0 |
| 2000-08-05 | vs FLO | 110 | L 5-10 | 55-55 | 2 | 37,369 | Rob Bell | A.J. Burnett | Antonio Alfonseca | Mark Wohlers | | 547 | 552 | -5 |
| 2000-08-06 | vs FLO | 111 | L 6-9 | 55-56 | 2 | 39,815 | Scott Williamson | Chuck Smith | Manny Aybar | Danny Graves | Braden Looper | 553 | 561 | -8 |
| 2000-08-07 | vs ATL | 112 | W 3-2 | 56-56 | 2 | 34,990 | Steve Parris | Greg Maddux | Scott Sullivan | Kerry Ligtenberg | | 556 | 563 | -7 |
| 2000-08-08 | vs ATL | 113 | L 4-5 | 56-57 | 2 | 32,381 | Elmer Dessens | Andy Ashby | Andy Ashby | Elmer Dessens | Mike Remlinger | 560 | 568 | -8 |
| 2000-08-09 | vs ATL | 114 | W 10-6 | 57-57 | 2 | 31,098 | Pete Harnisch | Tom Glavine | Pete Harnisch | Tom Glavine | | 570 | 574 | -4 |
| 2000-08-11 | @ CHN | 115 | W 6-4 | 58-57 | 2 | 40,586 | Rob Bell | Kevin Tapani | Mark Wohlers | Steve Rain | Danny Graves | 576 | 578 | -2 |
| 2000-08-12 | @ CHN | 116 | W 3-0 | 59-57 | 2 | 40,625 | Scott Williamson | Daniel Garibay | Scott Williamson | Daniel Garibay | Danny Graves | 579 | 578 | 1 |
| 2000-08-13 | @ CHN | 117 | W 3-0 | 60-57 | 2 | 38,787 | Steve Parris | Ruben Quevedo | Steve Parris | Ruben Quevedo | Scott Sullivan | 582 | 578 | 4 |
| 2000-08-14 | @ MIL | 118 | L 3-4 | 60-58 | 2 | 25,853 | Elmer Dessens | Paul Rigdon | Paul Rigdon | Elmer Dessens | Curt Leskanic | 585 | 582 | 3 |
| 2000-08-15 | @ MIL | 119 | L 1-2 | 60-59 | 2 | 19,649 | Pete Harnisch | John Snyder | Curt Leskanic | Mark Wohlers | | 586 | 584 | 2 |
| 2000-08-16 | @ MIL | 120 | L 1-5 | 60-60 | 2 | 26,339 | Rob Bell | Jeff D'Amico | Jeff D'Amico | Rob Bell | | 587 | 589 | -2 |
| 2000-08-18 | vs PIT | 121 | L 3-6 | 60-61 | 2 | 31,891 | Scott Williamson | Todd Ritchie | Todd Ritchie | Scott Sullivan | Mike Williams | 590 | 595 | -5 |
| 2000-08-19 | vs PIT | 122 | W 7-1 | 61-61 | 2 | 34,370 | Steve Parris | Jimmy Anderson | Steve Parris | Jimmy Anderson | | 597 | 596 | 1 |
| 2000-08-20 | vs PIT | 123 | L 3-7 | 61-62 | 2 | 32,545 | Elmer Dessens | Jose Silva | Jose Silva | Elmer Dessens | | 600 | 603 | -3 |
| 2000-08-21 | vs PHI | 124 | W 7-4 | 62-62 | 2 | 21,558 | Pete Harnisch | Randy Wolf | Pete Harnisch | Randy Wolf | Danny Graves | 607 | 607 | 0 |
| 2000-08-22 | vs PHI | 125 | L 4-5 | 62-63 | 2 | 22,470 | Rob Bell | Bruce Chen | Vicente Padilla | Larry Luebbers | Jeff Brantley | 611 | 612 | -1 |
| 2000-08-23 | vs PHI | 126 | L 3-4 | 62-64 | 2 | 20,255 | Scott Williamson | Robert Person | Chris Brock | Danny Graves | Vicente Padilla | 614 | 616 | -2 |
| 2000-08-24 | vs PHI | 127 | W 8-3 | 63-64 | 2 | 25,745 | Steve Parris | Omar Daal | Steve Parris | Omar Daal | | 622 | 619 | 3 |
| 2000-08-25 | @ FLO | 128 | W 6-0 | 64-64 | 2 | 25,042 | Elmer Dessens | Reid Cornelius | Elmer Dessens | Reid Cornelius | | 628 | 619 | 9 |
| 2000-08-26 | @ FLO | 129 | W 3-2 | 65-64 | 2 | 35,392 | Pete Harnisch | Jesus Sanchez | Pete Harnisch | Vic Darensbourg | Danny Graves | 631 | 621 | 10 |
| 2000-08-27 | @ FLO | 130 | L 6-7 | 65-65 | 2 | 21,920 | Rob Bell | Ryan Dempster | Dan Miceli | Danny Graves | | 637 | 628 | 9 |
| 2000-08-28 | @ ATL | 131 | W 6-3 | 66-65 | 2 | 35,048 | Ron Villone | Greg Maddux | Ron Villone | Greg Maddux | | 643 | 631 | 12 |
| 2000-08-29 | @ ATL | 132 | W 4-2 | 67-65 | 2 | 34,347 | Steve Parris | Andy Ashby | Steve Parris | Mike Remlinger | Danny Graves | 647 | 633 | 14 |
| 2000-08-30 | @ ATL | 133 | L 2-5 | 67-66 | 2 | 32,418 | Elmer Dessens | Tom Glavine | Tom Glavine | Elmer Dessens | | 649 | 638 | 11 |
| 2000-08-31 | @ ATL | 134 | W 4-3 | 68-66 | 2 | 38,647 | Pete Harnisch | Kevin Millwood | John Riedling | Kevin Millwood | Danny Graves | 653 | 641 | 12 |
| 2000-09-01 | vs MON | 135 | W 8-2 | 69-66 | 2 | 22,973 | Rob Bell | Dustin Hermanson | Rob Bell | Dustin Hermanson | | 661 | 643 | 18 |
| 2000-09-02 | vs MON | 136 | L 5-9 | 69-67 | 2 | 29,403 | Ron Villone | Trey Moore | Felipe Lira | Ron Villone | | 666 | 652 | 14 |
| 2000-09-03 | vs MON | 137 | W 8-1 | 70-67 | 2 | 26,152 | Steve Parris | Mike Thurman | Steve Parris | Mike Thurman | | 674 | 653 | 21 |
| 2000-09-04 | vs NYN | 138 | W 6-2 | 71-67 | 2 | 26,571 | Elmer Dessens | Al Leiter | Elmer Dessens | Al Leiter | | 680 | 655 | 25 |
| 2000-09-05 | vs NYN | 139 | L 2-3 | 71-68 | 2 | 22,664 | Pete Harnisch | Rick Reed | Turk Wendell | Scott Sullivan | Armando Benitez | 682 | 658 | 24 |
| 2000-09-06 | vs NYN | 140 | W 11-8 | 72-68 | 2 | 24,681 | Rob Bell | Robert Joseph Jones | John Riedling | John Franco | Danny Graves | 693 | 666 | 27 |
| 2000-09-08 | @ PIT | 141 | L 3-7 | 72-70 | 2 | 0 | Scott Williamson | Todd Ritchie | Todd Ritchie | Scott Williamson | | 696 | 673 | 23 |
| 2000-09-08 | @ PIT | 142 | L 1-3 | 72-70 | 2 | 26,486 | Ron Villone | Bronson Arroyo | Marc Wilkins | Ron Villone | Mike Williams | 697 | 676 | 21 |
| 2000-09-09 | @ PIT | 143 | W 6-4 | 73-70 | 2 | 34,590 | Steve Parris | Kris Benson | Steve Parris | Kris Benson | Danny Graves | 703 | 680 | 23 |
| 2000-09-10 | @ PIT | 144 | W 6-4 | 74-70 | 2 | 35,046 | Elmer Dessens | Jimmy Anderson | Elmer Dessens | Jimmy Anderson | Danny Graves | 709 | 684 | 25 |
| 2000-09-11 | vs CHN | 145 | W 7-6 | 75-70 | 2 | 22,532 | Pete Harnisch | Daniel Garibay | Pete Harnisch | Daniel Garibay | Danny Graves | 716 | 690 | 26 |
| 2000-09-12 | vs CHN | 146 | L 1-2 | 75-71 | 2 | 25,744 | Osvaldo Fernandez | Kerry Wood | Kerry Wood | Osvaldo Fernandez | | 717 | 692 | 25 |
| 2000-09-13 | vs CHN | 147 | W 13-3 | 76-71 | 2 | 23,590 | Rob Bell | Jamie Arnold | Rob Bell | Jamie Arnold | | 730 | 695 | 35 |
| 2000-09-14 | vs MIL | 148 | L 4-6 | 76-72 | 2 | 19,472 | Ron Villone | Jimmy Haynes | Jimmy Haynes | Ron Villone | Curt Leskanic | 734 | 701 | 33 |
| 2000-09-15 | vs MIL | 149 | W 6-4 | 77-72 | 2 | 24,354 | Steve Parris | Jamey Wright | Steve Parris | Jamey Wright | Danny Graves | 740 | 705 | 35 |
| 2000-09-16 | vs MIL | 150 | W 7-3 | 78-72 | 2 | 29,350 | Elmer Dessens | Paul Rigdon | Elmer Dessens | Paul Rigdon | John Riedling | 747 | 708 | 39 |
| 2000-09-17 | vs MIL | 151 | W 8-4 | 79-72 | 2 | 26,299 | Pete Harnisch | John Snyder | Pete Harnisch | John Snyder | | 755 | 712 | 43 |
| 2000-09-18 | @ SFN | 152 | W 7-1 | 80-72 | 2 | 40,930 | Osvaldo Fernandez | Shawn Estes | Osvaldo Fernandez | Shawn Estes | | 762 | 713 | 49 |
| 2000-09-19 | @ SFN | 153 | L 3-7 | 80-73 | 2 | 40,930 | Rob Bell | Livan Hernandez | Livan Hernandez | Rob Bell | | 765 | 720 | 45 |
| 2000-09-20 | @ SFN | 154 | L 2-4 | 80-74 | 2 | 40,930 | Steve Parris | Russ Ortiz | Russ Ortiz | Steve Parris | Robb Nen | 767 | 724 | 43 |
| 2000-09-22 | vs HOU | 155 | W 12-5 | 81-74 | 2 | 32,223 | Elmer Dessens | Jose Lima | Elmer Dessens | Jose Lima | | 779 | 729 | 50 |
| 2000-09-23 | vs HOU | 156 | W 6-4 | 82-74 | 2 | 32,660 | Pete Harnisch | Scott Elarton | John Riedling | Joe Slusarski | Danny Graves | 785 | 733 | 52 |
| 2000-09-24 | vs HOU | 157 | W 4-3 | 83-74 | 2 | 35,623 | Osvaldo Fernandez | Wade Miller | Scott Sullivan | Octavio Dotel | | 789 | 736 | 53 |
| 2000-09-26 | @ MIL | 158 | L 4-7 | 83-75 | 2 | 27,851 | Steve Parris | Jamey Wright | Jamey Wright | Steve Parris | Curt Leskanic | 793 | 743 | 50 |
| 2000-09-27 | @ MIL | 159 | L 6-10 | 83-76 | 2 | 27,262 | Rob Bell | Paul Rigdon | Valerio de los Santos | John Riedling | | 799 | 753 | 46 |
| 2000-09-28 | @ MIL | 160 | W 8-1 | 84-76 | 2 | 56,354 | Elmer Dessens | Jeff D'Amico | Elmer Dessens | Jeff D'Amico | | 807 | 754 | 53 |
| 2000-09-29 | @ SLN | 161 | W 8-1 | 85-76 | 2 | 46,152 | Ron Villone | Garrett Stephenson | Ron Villone | Garrett Stephenson | | 815 | 755 | 60 |
| 2000-09-30 | @ SLN | 162 | W 8-4 | 86-76 | 2 | 47,099 | Osvaldo Fernandez | Pat Hentgen | Osvaldo Fernandez | Pat Hentgen | | 823 | 759 | 64 |
| 2000-10-01 | @ SLN | 163 | L 2-6 | 86-77 | 2 | 47,533 | Steve Parris | Andy Benes | Andy Benes | Steve Parris | | 825 | 765 | 60 |