| 2000-04-03 | vs COL | 1 | W 2-0 | 1-0 | 1 | 42,255 | Greg Maddux | Pedro Astacio | Greg Maddux | Pedro Astacio | Mike Remlinger | 2 | 0 | 2 |
| 2000-04-04 | vs COL | 2 | L 3-5 | 1-1 | 2 | 26,132 | Tom Glavine | Rolando Arrojo | Julian Tavarez | John Burkett | Jose Jimenez | 5 | 5 | 0 |
| 2000-04-05 | vs COL | 3 | W 9-6 | 2-1 | 1 | 30,008 | Kevin Millwood | Brian Bohanon | Bruce Chen | Manny Aybar | Kerry Ligtenberg | 14 | 11 | 3 |
| 2000-04-07 | vs SFN | 4 | L 2-6 | 2-2 | 2 | 35,343 | Terry Mulholland | Mark Gardner | Mark Gardner | Terry Mulholland | | 16 | 17 | -1 |
| 2000-04-08 | vs SFN | 5 | W 7-5 | 3-2 | 1 | 35,938 | Greg Maddux | Livan Hernandez | Greg Maddux | Livan Hernandez | Kerry Ligtenberg | 23 | 22 | 1 |
| 2000-04-09 | vs SFN | 6 | W 9-3 | 4-2 | 1 | 32,654 | Tom Glavine | Russ Ortiz | Tom Glavine | Russ Ortiz | | 32 | 25 | 7 |
| 2000-04-10 | @ CHN | 7 | L 3-4 | 4-3 | 1 | 38,655 | Kevin Millwood | Jon Lieber | Mark Guthrie | Kerry Ligtenberg | | 35 | 29 | 6 |
| 2000-04-12 | @ CHN | 8 | L 4-11 | 4-4 | 3 | 26,838 | Terry Mulholland | Kyle Farnsworth | Kyle Farnsworth | Terry Mulholland | | 39 | 40 | -1 |
| 2000-04-13 | @ CHN | 9 | L 2-3 | 4-5 | 3 | 20,152 | Greg Maddux | Kevin Tapani | Mark Guthrie | Mike Remlinger | | 41 | 43 | -2 |
| 2000-04-14 | @ MIL | 10 | W 6-3 | 5-5 | 3 | 10,171 | Tom Glavine | Steve Woodard | Tom Glavine | Steve Woodard | Mike Remlinger | 47 | 46 | 1 |
| 2000-04-15 | @ MIL | 11 | L 3-6 | 5-6 | 3 | 24,755 | Kevin Millwood | Jimmy Haynes | David Weathers | John Burkett | Bob Wickman | 50 | 52 | -2 |
| 2000-04-16 | @ MIL | 12 | W 2-1 | 6-6 | 2 | 12,004 | Terry Mulholland | Everett Stull | Terry Mulholland | Everett Stull | Mike Remlinger | 52 | 53 | -1 |
| 2000-04-18 | vs PHI | 13 | W 4-3 | 7-6 | 2 | 34,903 | Greg Maddux | Robert Person | Luis Rivera | Carlos Reyes | | 56 | 56 | 0 |
| 2000-04-19 | vs PHI | 14 | W 10-1 | 8-6 | 1 | 29,992 | Tom Glavine | Randy Wolf | Tom Glavine | Randy Wolf | | 66 | 57 | 9 |
| 2000-04-20 | vs PHI | 15 | W 6-4 | 9-6 | 1 | 31,451 | Kevin Millwood | Chris Brock | Kevin Millwood | Scott Aldred | John Rocker | 72 | 61 | 11 |
| 2000-04-21 | vs PIT | 16 | W 6-2 | 10-6 | 1 | 33,790 | Terry Mulholland | Jose Parra | Terry Mulholland | Mike Garcia | | 78 | 63 | 15 |
| 2000-04-22 | vs PIT | 17 | W 4-2 | 11-6 | 1 | 41,389 | John Burkett | Kris Benson | Bruce Chen | Kris Benson | John Rocker | 82 | 65 | 17 |
| 2000-04-23 | vs PIT | 18 | W 5-3 | 12-6 | 1 | 29,463 | Greg Maddux | Francisco Cordova | Greg Maddux | Francisco Cordova | John Rocker | 87 | 68 | 19 |
| 2000-04-25 | vs LAN | 19 | W 1-0 | 13-6 | 1 | 35,046 | Tom Glavine | Kevin Brown | Tom Glavine | Kevin Brown | | 88 | 68 | 20 |
| 2000-04-26 | vs LAN | 20 | W 5-1 | 14-6 | 1 | 31,734 | Kevin Millwood | Eric Gagne | Kevin Millwood | Eric Gagne | | 93 | 69 | 24 |
| 2000-04-27 | vs LAN | 21 | W 6-3 | 15-6 | 1 | 37,750 | Terry Mulholland | Chan Ho Park | Terry Mulholland | Chan Ho Park | John Rocker | 99 | 72 | 27 |
| 2000-04-28 | @ SDN | 22 | W 7-2 | 16-6 | 1 | 33,995 | Greg Maddux | Brian Meadows | Greg Maddux | Brian Meadows | Mike Remlinger | 106 | 74 | 32 |
| 2000-04-29 | @ SDN | 23 | W 7-4 | 17-6 | 1 | 49,428 | John Burkett | Rodrigo Lopez | Bruce Chen | Vicente Palacios | John Rocker | 113 | 78 | 35 |
| 2000-04-30 | @ SDN | 24 | W 7-4 | 18-6 | 1 | 44,845 | Tom Glavine | Sterling Hitchcock | Tom Glavine | Sterling Hitchcock | | 120 | 82 | 38 |
| 2000-05-01 | @ LAN | 25 | W 2-1 | 19-6 | 1 | 28,790 | Kevin Millwood | Eric Gagne | Kevin Millwood | Eric Gagne | John Rocker | 122 | 83 | 39 |
| 2000-05-02 | @ LAN | 26 | W 5-3 | 20-6 | 1 | 30,246 | Terry Mulholland | Chan Ho Park | Bruce Chen | Terry Adams | John Rocker | 127 | 86 | 41 |
| 2000-05-03 | @ LAN | 27 | L 4-6 | 20-7 | 1 | 34,960 | Greg Maddux | Carlos Perez | Carlos Perez | Greg Maddux | Jeff Shaw | 131 | 92 | 39 |
| 2000-05-05 | vs PHI | 28 | W 6-5 | 21-7 | 1 | 40,174 | Tom Glavine | Randy Wolf | Rudy Seanez | Wayne Gomes | | 137 | 97 | 40 |
| 2000-05-06 | vs PHI | 29 | L 0-6 | 21-8 | 1 | 48,610 | Kevin Millwood | Curt Schilling | Curt Schilling | Kevin Millwood | | 137 | 103 | 34 |
| 2000-05-07 | vs PHI | 30 | L 4-7 | 21-9 | 1 | 40,613 | Terry Mulholland | Andy Ashby | Andy Ashby | Terry Mulholland | Wayne Gomes | 141 | 110 | 31 |
| 2000-05-08 | @ FLO | 31 | L 2-3 | 21-10 | 1 | 14,024 | Greg Maddux | Vladimir Nunez | Dan Miceli | Rudy Seanez | | 143 | 113 | 30 |
| 2000-05-09 | @ FLO | 32 | W 10-5 | 22-10 | 1 | 12,564 | John Burkett | Brad Penny | John Burkett | Brad Penny | | 153 | 118 | 35 |
| 2000-05-10 | @ FLO | 33 | L 3-5 | 22-11 | 1 | 15,249 | Tom Glavine | Jesus Sanchez | Jesus Sanchez | Tom Glavine | Antonio Alfonseca | 156 | 123 | 33 |
| 2000-05-11 | @ FLO | 34 | L 4-5 | 22-12 | 1 | 14,587 | Kevin Millwood | Jason Grilli | Jason Grilli | Kevin Millwood | Antonio Alfonseca | 160 | 128 | 32 |
| 2000-05-12 | @ PHI | 35 | W 8-7 | 23-12 | 1 | 21,922 | Terry Mulholland | Curt Schilling | Kerry Ligtenberg | Wayne Gomes | John Rocker | 168 | 135 | 33 |
| 2000-05-13 | @ PHI | 36 | W 3-2 | 24-12 | 1 | 20,516 | Greg Maddux | Andy Ashby | Rudy Seanez | Scott Aldred | John Rocker | 171 | 137 | 34 |
| 2000-05-14 | @ PHI | 37 | W 11-2 | 25-12 | 1 | 22,258 | John Burkett | Paul Byrd | John Burkett | Paul Byrd | | 182 | 139 | 43 |
| 2000-05-16 | vs SFN | 38 | W 9-7 | 26-12 | 1 | 35,808 | Tom Glavine | Russ Ortiz | Tom Glavine | Russ Ortiz | Terry Mulholland | 191 | 146 | 45 |
| 2000-05-17 | vs SFN | 39 | W 5-4 | 27-12 | 1 | 33,138 | Kevin Millwood | Kirk Rueter | Kevin Millwood | Kirk Rueter | Rudy Seanez | 196 | 150 | 46 |
| 2000-05-18 | vs SFN | 40 | W 3-2 | 28-12 | 1 | 42,222 | Greg Maddux | Shawn Estes | Greg Maddux | Shawn Estes | John Rocker | 199 | 152 | 47 |
| 2000-05-19 | vs SDN | 41 | L 7-11 | 28-13 | 1 | 39,423 | Terry Mulholland | Brian Meadows | Matt Whiteside | Terry Mulholland | Trevor Hoffman | 206 | 163 | 43 |
| 2000-05-20 | vs SDN | 42 | W 10-6 | 29-13 | 1 | 49,653 | John Burkett | Will Cunnane | John Burkett | Will Cunnane | | 216 | 169 | 47 |
| 2000-05-21 | vs SDN | 43 | W 12-6 | 30-13 | 1 | 40,533 | Tom Glavine | Sterling Hitchcock | Tom Glavine | Sterling Hitchcock | | 228 | 175 | 53 |
| 2000-05-23 | @ MIL | 44 | L 6-7 | 30-14 | 1 | 15,808 | Kevin Millwood | Jamey Wright | Jamey Wright | Kevin Millwood | Bob Wickman | 234 | 182 | 52 |
| 2000-05-24 | @ MIL | 45 | W 11-2 | 31-14 | 1 | 18,153 | Greg Maddux | Jimmy Haynes | Greg Maddux | Jimmy Haynes | | 245 | 184 | 61 |
| 2000-05-25 | @ MIL | 46 | W 7-3 | 32-14 | 1 | 21,527 | Terry Mulholland | Jeff D'Amico | Terry Mulholland | Jeff D'Amico | | 252 | 187 | 65 |
| 2000-05-26 | @ HOU | 47 | L 4-5 | 32-15 | 1 | 42,027 | Tom Glavine | Jose Lima | Doug Henry | Rudy Seanez | | 256 | 192 | 64 |
| 2000-05-27 | @ HOU | 48 | W 6-5 | 33-15 | 1 | 42,632 | John Burkett | Shane Reynolds | John Burkett | Shane Reynolds | Kerry Ligtenberg | 262 | 197 | 65 |
| 2000-05-28 | @ HOU | 49 | L 3-4 | 33-16 | 1 | 42,777 | Kevin Millwood | Chris Holt | Marc Valdes | Rudy Seanez | Billy Wagner | 265 | 201 | 64 |
| 2000-05-29 | @ CHN | 50 | W 1-0 | 34-16 | 1 | 40,123 | Greg Maddux | Jon Lieber | Greg Maddux | Jon Lieber | | 266 | 201 | 65 |
| 2000-05-30 | @ CHN | 51 | W 5-2 | 35-16 | 1 | 35,511 | Terry Mulholland | Ruben Quevedo | Terry Mulholland | Ruben Quevedo | Mike Remlinger | 271 | 203 | 68 |
| 2000-06-01 | @ CHN | 52 | L 3-5 | 35-17 | 1 | 5,267 | Tom Glavine | Kevin Tapani | Kevin Tapani | Tom Glavine | Rick Aguilera | 274 | 208 | 66 |
| 2000-06-02 | vs NYA | 53 | L 2-5 | 35-18 | 1 | 48,524 | Kevin Millwood | Orlando Hernandez | Orlando Hernandez | Kevin Millwood | Mariano Rivera | 276 | 213 | 63 |
| 2000-06-03 | vs NYA | 54 | W 11-7 | 36-18 | 1 | 48,423 | Greg Maddux | Roger Clemens | Mike Remlinger | Jason Grimsley | | 287 | 220 | 67 |
| 2000-06-04 | vs NYA | 55 | L 6-7 | 36-19 | 1 | 47,756 | Terry Mulholland | Andy Pettitte | Andy Pettitte | Terry Mulholland | Mariano Rivera | 293 | 227 | 66 |
| 2000-06-05 | vs TOR | 56 | L 3-9 | 36-20 | 1 | 33,641 | John Burkett | David Wells | David Wells | John Burkett | | 296 | 236 | 60 |
| 2000-06-06 | vs TOR | 57 | W 7-6 | 37-20 | 1 | 39,454 | Tom Glavine | Frank Castillo | Mike Remlinger | John Frascatore | | 303 | 242 | 61 |
| 2000-06-07 | vs TOR | 58 | L 8-12 | 37-21 | 1 | 33,240 | Kevin Millwood | Clayton Andrews | Darwin Cubillan | Kevin Millwood | Billy Koch | 311 | 254 | 57 |
| 2000-06-09 | vs BOS | 59 | W 6-4 | 38-21 | 1 | 48,053 | Greg Maddux | Jeff Fassero | Greg Maddux | Jeff Fassero | Rudy Seanez | 317 | 258 | 59 |
| 2000-06-10 | vs BOS | 60 | W 6-0 | 39-21 | 1 | 49,420 | Terry Mulholland | Pete Schourek | Terry Mulholland | Pete Schourek | | 323 | 258 | 65 |
| 2000-06-11 | vs BOS | 61 | L 3-5 | 39-22 | 1 | 47,437 | Tom Glavine | Ramon Martinez | Rich Garces | Rudy Seanez | Derek Lowe | 326 | 263 | 63 |
| 2000-06-12 | @ PIT | 62 | W 10-8 | 40-22 | 1 | 15,196 | Kevin Millwood | Todd Ritchie | Kerry Ligtenberg | Jason Christiansen | Mike Remlinger | 336 | 271 | 65 |
| 2000-06-13 | @ PIT | 63 | L 6-7 | 40-23 | 1 | 17,971 | John Burkett | Bronson Arroyo | Jose Silva | Don Wengert | | 342 | 278 | 64 |
| 2000-06-14 | @ PIT | 64 | W 8-4 | 41-23 | 1 | 16,972 | Greg Maddux | Jimmy Anderson | Greg Maddux | Jimmy Anderson | Kerry Ligtenberg | 350 | 282 | 68 |
| 2000-06-15 | @ PIT | 65 | L 0-2 | 41-24 | 1 | 19,065 | Kevin Millwood | Kris Benson | Kris Benson | Kevin Millwood | | 350 | 284 | 66 |
| 2000-06-16 | @ PHI | 66 | L 1-2 | 41-25 | 1 | 20,495 | Tom Glavine | Curt Schilling | Curt Schilling | Tom Glavine | Jeff Brantley | 351 | 286 | 65 |
| 2000-06-17 | @ PHI | 67 | L 3-9 | 41-26 | 1 | 37,292 | Terry Mulholland | Cliff Politte | Cliff Politte | Terry Mulholland | | 354 | 295 | 59 |
| 2000-06-18 | @ PHI | 68 | W 5-3 | 42-26 | 1 | 25,359 | John Burkett | Robert Person | John Burkett | Steve Schrenk | John Rocker | 359 | 298 | 61 |
| 2000-06-19 | @ PHI | 69 | L 2-5 | 42-27 | 1 | 22,264 | Greg Maddux | Randy Wolf | Chris Brock | Mike Remlinger | Jeff Brantley | 361 | 303 | 58 |
| 2000-06-20 | vs CHN | 70 | W 11-4 | 43-27 | 1 | 46,618 | Kevin Millwood | Kevin Tapani | Kevin Millwood | Kevin Tapani | | 372 | 307 | 65 |
| 2000-06-21 | vs CHN | 71 | L 1-8 | 43-28 | 1 | 44,698 | Tom Glavine | Kerry Wood | Kerry Wood | Tom Glavine | | 373 | 315 | 58 |
| 2000-06-22 | vs CHN | 72 | W 6-4 | 44-28 | 1 | 47,893 | Terry Mulholland | Scott Downs | Terry Mulholland | Scott Downs | Mike Remlinger | 379 | 319 | 60 |
| 2000-06-23 | vs MIL | 73 | W 3-2 | 45-28 | 1 | 41,402 | John Burkett | Jason Bere | Jason Marquis | David Weathers | John Rocker | 382 | 321 | 61 |
| 2000-06-24 | vs MIL | 74 | L 1-2 | 45-29 | 1 | 49,802 | Greg Maddux | Jamey Wright | Jamey Wright | Greg Maddux | Bob Wickman | 383 | 323 | 60 |
| 2000-06-25 | vs MIL | 75 | W 5-4 | 46-29 | 1 | 40,268 | Kevin Millwood | Allen Levrault | John Rocker | Curt Leskanic | | 388 | 327 | 61 |
| 2000-06-27 | @ MON | 76 | L 4-6 | 46-30 | 1 | 11,636 | Tom Glavine | Tony Armas | Tony Armas | Tom Glavine | Steve Kline | 392 | 333 | 59 |
| 2000-06-28 | @ MON | 77 | W 7-4 | 47-30 | 1 | 12,653 | Terry Mulholland | Dustin Hermanson | Terry Mulholland | Dustin Hermanson | Kerry Ligtenberg | 399 | 337 | 62 |
| 2000-06-29 | @ NYN | 78 | W 6-4 | 48-30 | 1 | 46,998 | John Burkett | Rick Reed | John Burkett | Rick Reed | Kerry Ligtenberg | 405 | 341 | 64 |
| 2000-06-30 | @ NYN | 79 | L 8-11 | 48-31 | 1 | 52,831 | Kevin Millwood | Mike Hampton | Armando Benitez | Terry Mulholland | | 413 | 352 | 61 |
| 2000-07-01 | @ NYN | 80 | L 1-9 | 48-32 | 1 | 44,593 | Greg Maddux | Al Leiter | Al Leiter | Greg Maddux | | 414 | 361 | 53 |
| 2000-07-02 | @ NYN | 81 | W 10-2 | 49-32 | 1 | 45,261 | Tom Glavine | Glendon Rusch | Tom Glavine | Glendon Rusch | | 424 | 363 | 61 |
| 2000-07-03 | vs MON | 82 | L 1-17 | 49-33 | 1 | 44,302 | Terry Mulholland | Tony Armas | Tony Armas | Terry Mulholland | | 425 | 380 | 45 |
| 2000-07-04 | vs MON | 83 | W 7-3 | 50-33 | 1 | 47,277 | Greg Maddux | Dustin Hermanson | Greg Maddux | Dustin Hermanson | | 432 | 383 | 49 |
| 2000-07-05 | vs MON | 84 | L 5-6 | 50-34 | 1 | 34,044 | Kevin Millwood | Javier Vazquez | Javier Vazquez | Kevin Millwood | Steve Kline | 437 | 389 | 48 |
| 2000-07-06 | vs MON | 85 | L 2-4 | 50-35 | 1 | 36,377 | John Burkett | Mike Johnson | Mike Johnson | John Burkett | Steve Kline | 439 | 393 | 46 |
| 2000-07-07 | @ BOS | 86 | W 5-3 | 51-35 | 1 | 33,686 | Tom Glavine | Pete Schourek | Tom Glavine | Pete Schourek | Kerry Ligtenberg | 444 | 396 | 48 |
| 2000-07-08 | @ BOS | 87 | W 5-1 | 52-35 | 1 | 33,311 | Terry Mulholland | Ramon Martinez | Terry Mulholland | Ramon Martinez | | 449 | 397 | 52 |
| 2000-07-09 | @ BOS | 88 | L 2-7 | 52-36 | 1 | 33,018 | Kevin Millwood | Tim Wakefield | Tim Wakefield | Kevin Millwood | | 451 | 404 | 47 |
| 2000-07-13 | @ BAL | 89 | W 6-3 | 53-36 | 1 | 47,284 | Greg Maddux | Mike Mussina | Greg Maddux | Mike Mussina | Scott Kamieniecki | 457 | 407 | 50 |
| 2000-07-14 | @ BAL | 90 | W 4-1 | 54-36 | 1 | 47,715 | Andy Ashby | Sidney Ponson | Andy Ashby | Sidney Ponson | | 461 | 408 | 53 |
| 2000-07-15 | @ BAL | 91 | W 7-3 | 55-36 | 1 | 49,013 | Tom Glavine | Scott Erickson | Tom Glavine | Scott Erickson | | 468 | 411 | 57 |
| 2000-07-16 | @ TBA | 92 | W 6-4 | 56-36 | 1 | 41,066 | Kevin Millwood | Esteban Yan | Scott Kamieniecki | Jim Mecir | | 474 | 415 | 59 |
| 2000-07-17 | @ TBA | 93 | L 6-8 | 56-37 | 1 | 28,538 | Terry Mulholland | Ryan Rupe | Ryan Rupe | Terry Mulholland | Roberto Hernandez | 480 | 423 | 57 |
| 2000-07-18 | @ TBA | 94 | W 8-2 | 57-37 | 1 | 31,354 | Greg Maddux | Bryan Rekar | Greg Maddux | Bryan Rekar | | 488 | 425 | 63 |
| 2000-07-20 | @ FLO | 95 | W 5-3 | 58-38 | 1 | 0 | Tom Glavine | Ryan Dempster | Tom Glavine | Ryan Dempster | Kerry Ligtenberg | 493 | 428 | 65 |
| 2000-07-20 | @ FLO | 96 | L 1-6 | 58-38 | 1 | 28,978 | Kevin Millwood | A.J. Burnett | A.J. Burnett | Scott Kamieniecki | | 494 | 434 | 60 |
| 2000-07-21 | vs NYN | 97 | W 6-3 | 59-38 | 1 | 49,313 | Terry Mulholland | Al Leiter | John Burkett | Al Leiter | Mike Remlinger | 500 | 437 | 63 |
| 2000-07-22 | vs NYN | 98 | L 0-4 | 59-39 | 1 | 48,141 | Greg Maddux | Rick Reed | Rick Reed | Greg Maddux | | 500 | 441 | 59 |
| 2000-07-23 | vs NYN | 99 | W 1-0 | 60-39 | 1 | 46,872 | Andy Ashby | Robert Joseph Jones | Andy Ashby | Robert Joseph Jones | | 501 | 441 | 60 |
| 2000-07-25 | vs FLO | 100 | W 6-5 | 61-39 | 1 | 41,990 | Tom Glavine | Ryan Dempster | Tom Glavine | Ryan Dempster | Kerry Ligtenberg | 507 | 446 | 61 |
| 2000-07-26 | vs FLO | 101 | W 6-3 | 62-39 | 1 | 34,325 | Kevin Millwood | A.J. Burnett | Kevin Millwood | A.J. Burnett | John Rocker | 513 | 449 | 64 |
| 2000-07-27 | vs FLO | 102 | L 4-12 | 62-40 | 1 | 37,535 | Greg Maddux | Chuck Smith | Chuck Smith | Greg Maddux | | 517 | 461 | 56 |
| 2000-07-28 | vs HOU | 103 | W 5-2 | 63-40 | 1 | 47,906 | Andy Ashby | Wade Miller | Andy Ashby | Wade Miller | John Rocker | 522 | 463 | 59 |
| 2000-07-29 | vs HOU | 104 | W 13-5 | 64-40 | 1 | 47,889 | John Burkett | Shane Reynolds | John Burkett | Shane Reynolds | | 535 | 468 | 67 |
| 2000-07-30 | vs HOU | 105 | W 6-3 | 65-40 | 1 | 40,613 | Tom Glavine | Chris Holt | Tom Glavine | Chris Holt | Mike Remlinger | 541 | 471 | 70 |
| 2000-08-01 | @ ARI | 106 | W 4-2 | 66-40 | 1 | 35,138 | Kevin Millwood | Armando Reynoso | Kevin Millwood | Greg Swindell | Mike Remlinger | 545 | 473 | 72 |
| 2000-08-02 | @ ARI | 107 | L 0-2 | 66-41 | 1 | 40,643 | Greg Maddux | Curt Schilling | Curt Schilling | Greg Maddux | | 545 | 475 | 70 |
| 2000-08-03 | @ ARI | 108 | L 4-8 | 66-42 | 1 | 35,441 | Andy Ashby | Brian Anderson | Brian Anderson | Andy Ashby | | 549 | 483 | 66 |
| 2000-08-04 | @ SLN | 109 | W 6-4 | 67-42 | 1 | 48,901 | Tom Glavine | Andy Benes | Tom Glavine | Andy Benes | Scott Kamieniecki | 555 | 487 | 68 |
| 2000-08-05 | @ SLN | 110 | L 0-5 | 67-43 | 1 | 47,709 | John Burkett | Garrett Stephenson | Garrett Stephenson | John Burkett | | 555 | 492 | 63 |
| 2000-08-06 | @ SLN | 111 | W 6-4 | 68-43 | 1 | 47,623 | Kevin Millwood | Darryl Kile | Mike Remlinger | Darryl Kile | Kerry Ligtenberg | 561 | 496 | 65 |
| 2000-08-07 | @ CIN | 112 | L 2-3 | 68-44 | 1 | 34,990 | Greg Maddux | Steve Parris | Scott Sullivan | Kerry Ligtenberg | | 563 | 499 | 64 |
| 2000-08-08 | @ CIN | 113 | W 5-4 | 69-44 | 1 | 32,381 | Andy Ashby | Elmer Dessens | Andy Ashby | Elmer Dessens | Mike Remlinger | 568 | 503 | 65 |
| 2000-08-09 | @ CIN | 114 | L 6-10 | 69-45 | 1 | 31,098 | Tom Glavine | Pete Harnisch | Pete Harnisch | Tom Glavine | | 574 | 513 | 61 |
| 2000-08-11 | vs LAN | 115 | W 7-2 | 70-45 | 1 | 48,824 | Kevin Millwood | Chan Ho Park | Mike Remlinger | Terry Adams | | 581 | 515 | 66 |
| 2000-08-12 | vs LAN | 116 | W 4-1 | 71-45 | 1 | 47,806 | Greg Maddux | Ismael Valdez | Greg Maddux | Ismael Valdez | Kerry Ligtenberg | 585 | 516 | 69 |
| 2000-08-13 | vs LAN | 117 | L 2-7 | 71-46 | 1 | 40,443 | Andy Ashby | Darren Dreifort | Darren Dreifort | Andy Ashby | | 587 | 523 | 64 |
| 2000-08-14 | vs SDN | 118 | W 9-2 | 72-46 | 1 | 31,316 | Tom Glavine | Jay Witasick | Tom Glavine | Jay Witasick | | 596 | 525 | 71 |
| 2000-08-15 | vs SDN | 119 | W 3-1 | 73-46 | 1 | 33,543 | John Burkett | Woody Williams | Mike Remlinger | Woody Williams | John Rocker | 599 | 526 | 73 |
| 2000-08-16 | vs SDN | 120 | W 4-1 | 74-46 | 1 | 31,650 | Kevin Millwood | Adam Eaton | Scott Kamieniecki | Kevin Walker | John Rocker | 603 | 527 | 76 |
| 2000-08-18 | @ SFN | 121 | L 0-2 | 74-47 | 1 | 40,930 | Greg Maddux | Livan Hernandez | Livan Hernandez | Greg Maddux | | 603 | 529 | 74 |
| 2000-08-19 | @ SFN | 122 | L 3-12 | 74-48 | 1 | 40,930 | Andy Ashby | Russ Ortiz | Russ Ortiz | Andy Ashby | | 606 | 541 | 65 |
| 2000-08-20 | @ SFN | 123 | W 8-5 | 75-48 | 1 | 40,930 | Tom Glavine | Kirk Rueter | Tom Glavine | Kirk Rueter | | 614 | 546 | 68 |
| 2000-08-21 | @ COL | 124 | W 7-4 | 76-48 | 1 | 43,015 | Kevin Millwood | Brian Bohanon | Kevin Millwood | Brian Bohanon | John Rocker | 621 | 550 | 71 |
| 2000-08-22 | @ COL | 125 | L 6-7 | 76-49 | 1 | 41,707 | John Burkett | Masato Yoshii | Brent Mayne | John Rocker | | 627 | 557 | 70 |
| 2000-08-23 | @ COL | 126 | W 5-2 | 77-49 | 1 | 41,850 | Greg Maddux | Brian Rose | Greg Maddux | Brian Rose | Mike Remlinger | 632 | 559 | 73 |
| 2000-08-24 | vs SLN | 127 | L 5-12 | 77-50 | 1 | 41,166 | Andy Ashby | Pat Hentgen | Pat Hentgen | Andy Ashby | | 637 | 571 | 66 |
| 2000-08-25 | vs SLN | 128 | W 7-4 | 78-50 | 1 | 46,695 | Tom Glavine | Britt Reames | Tom Glavine | Mike Timlin | Kerry Ligtenberg | 644 | 575 | 69 |
| 2000-08-26 | vs SLN | 129 | L 3-6 | 78-51 | 1 | 49,475 | Kevin Millwood | Garrett Stephenson | Garrett Stephenson | Kevin Millwood | | 647 | 581 | 66 |
| 2000-08-27 | vs SLN | 130 | L 2-7 | 78-52 | 1 | 46,574 | John Burkett | Darryl Kile | Darryl Kile | Kerry Ligtenberg | | 649 | 588 | 61 |
| 2000-08-28 | vs CIN | 131 | L 3-6 | 78-53 | 1 | 35,048 | Greg Maddux | Ron Villone | Ron Villone | Greg Maddux | | 652 | 594 | 58 |
| 2000-08-29 | vs CIN | 132 | L 2-4 | 78-54 | 1 | 34,347 | Andy Ashby | Steve Parris | Steve Parris | Mike Remlinger | Danny Graves | 654 | 598 | 56 |
| 2000-08-30 | vs CIN | 133 | W 5-2 | 79-54 | 1 | 32,418 | Tom Glavine | Elmer Dessens | Tom Glavine | Elmer Dessens | | 659 | 600 | 59 |
| 2000-08-31 | vs CIN | 134 | L 3-4 | 79-55 | 2 | 38,647 | Kevin Millwood | Pete Harnisch | John Riedling | Kevin Millwood | Danny Graves | 662 | 604 | 58 |
| 2000-09-01 | @ HOU | 135 | L 2-3 | 79-56 | 2 | 38,845 | John Burkett | Jose Lima | Jose Lima | John Burkett | Octavio Dotel | 664 | 607 | 57 |
| 2000-09-02 | @ HOU | 136 | W 8-6 | 80-56 | 1 | 43,189 | Greg Maddux | Scott Elarton | Greg Maddux | Scott Elarton | John Rocker | 672 | 613 | 59 |
| 2000-09-03 | @ HOU | 137 | L 3-9 | 80-57 | 1 | 43,009 | Andy Ashby | Wade Miller | Wade Miller | Andy Ashby | | 675 | 622 | 53 |
| 2000-09-05 | vs ARI | 138 | W 5-2 | 81-57 | 1 | 29,722 | Tom Glavine | Randy Johnson | Tom Glavine | Randy Johnson | John Rocker | 680 | 624 | 56 |
| 2000-09-06 | vs ARI | 139 | W 7-1 | 82-57 | 1 | 25,529 | Kevin Millwood | Armando Reynoso | Kevin Millwood | Armando Reynoso | | 687 | 625 | 62 |
| 2000-09-07 | vs ARI | 140 | W 4-0 | 83-57 | 1 | 30,446 | Greg Maddux | Curt Schilling | Greg Maddux | Curt Schilling | | 691 | 625 | 66 |
| 2000-09-08 | vs MON | 141 | W 3-2 | 84-57 | 1 | 35,870 | Andy Ashby | Trey Moore | Andy Ashby | Trey Moore | John Rocker | 694 | 627 | 67 |
| 2000-09-09 | vs MON | 142 | L 5-7 | 84-58 | 1 | 47,775 | John Burkett | Mike Thurman | Julio Santana | Chris Seelbach | | 699 | 634 | 65 |
| 2000-09-10 | vs MON | 143 | L 0-4 | 84-59 | 1 | 39,068 | Tom Glavine | Javier Vazquez | Javier Vazquez | Tom Glavine | | 699 | 638 | 61 |
| 2000-09-12 | vs FLO | 144 | L 4-5 | 84-60 | 1 | 27,762 | Kevin Millwood | Jesus Sanchez | Jesus Sanchez | Kevin Millwood | Antonio Alfonseca | 703 | 643 | 60 |
| 2000-09-13 | vs FLO | 145 | W 4-0 | 85-60 | 1 | 29,573 | Greg Maddux | Ryan Dempster | Greg Maddux | Ryan Dempster | | 707 | 643 | 64 |
| 2000-09-14 | vs FLO | 146 | W 5-3 | 86-60 | 1 | 33,298 | Andy Ashby | Reid Cornelius | Andy Ashby | Reid Cornelius | John Rocker | 712 | 646 | 66 |
| 2000-09-15 | @ ARI | 147 | L 1-2 | 86-61 | 1 | 39,774 | Tom Glavine | Randy Johnson | Randy Johnson | Tom Glavine | Matt Mantei | 713 | 648 | 65 |
| 2000-09-16 | @ ARI | 148 | W 12-10 | 87-61 | 1 | 41,470 | John Burkett | Todd Stottlemyre | John Burkett | Todd Stottlemyre | John Rocker | 725 | 658 | 67 |
| 2000-09-17 | @ ARI | 149 | W 7-1 | 88-61 | 1 | 38,364 | Kevin Millwood | Curt Schilling | Kevin Millwood | Curt Schilling | | 732 | 659 | 73 |
| 2000-09-18 | vs NYN | 150 | W 6-3 | 89-61 | 1 | 41,937 | Greg Maddux | Mike Hampton | Greg Maddux | Mike Hampton | John Rocker | 738 | 662 | 76 |
| 2000-09-19 | vs NYN | 151 | W 12-4 | 90-61 | 1 | 46,584 | Andy Ashby | Glendon Rusch | Andy Ashby | Glendon Rusch | | 750 | 666 | 84 |
| 2000-09-20 | vs NYN | 152 | L 3-6 | 90-62 | 1 | 48,278 | Tom Glavine | Al Leiter | Al Leiter | Tom Glavine | Armando Benitez | 753 | 672 | 81 |
| 2000-09-22 | @ MON | 153 | L 4-6 | 90-63 | 1 | 8,464 | Kevin Millwood | Tony Armas | Tony Armas | Kevin Millwood | Scott Strickland | 757 | 678 | 79 |
| 2000-09-23 | @ MON | 154 | W 10-0 | 91-63 | 1 | 10,136 | Greg Maddux | Felipe Lira | Greg Maddux | Felipe Lira | | 767 | 678 | 89 |
| 2000-09-24 | @ MON | 155 | W 14-5 | 92-63 | 1 | 11,350 | Andy Ashby | Mike Thurman | Andy Ashby | Mike Thurman | | 781 | 683 | 98 |
| 2000-09-25 | @ MON | 156 | W 6-0 | 93-63 | 1 | 6,931 | Tom Glavine | Javier Vazquez | Tom Glavine | Javier Vazquez | | 787 | 683 | 104 |
| 2000-09-26 | @ NYN | 157 | W 7-1 | 94-63 | 1 | 48,270 | John Burkett | Al Leiter | John Burkett | Al Leiter | | 794 | 684 | 110 |
| 2000-09-27 | @ NYN | 158 | L 2-6 | 94-64 | 1 | 48,858 | Kevin Millwood | Rick Reed | Rick Reed | Kevin Millwood | | 796 | 690 | 106 |
| 2000-09-28 | @ NYN | 159 | L 2-8 | 94-65 | 1 | 52,134 | Greg Maddux | Robert Joseph Jones | Robert Joseph Jones | Greg Maddux | | 798 | 698 | 100 |
| 2000-09-29 | vs COL | 160 | L 2-4 | 94-66 | 1 | 44,548 | Andy Ashby | Brian Bohanon | Brian Bohanon | Andy Ashby | Jose Jimenez | 800 | 702 | 98 |
| 2000-09-30 | vs COL | 161 | W 5-2 | 95-66 | 1 | 48,933 | Tom Glavine | Brian Rose | Tom Glavine | Brian Rose | John Rocker | 805 | 704 | 101 |
| 2000-10-01 | vs COL | 162 | L 5-10 | 95-67 | 1 | 45,794 | John Burkett | Kevin Jarvis | Julian Tavarez | John Rocker | | 810 | 714 | 96 |