| 2000-04-03 | vs CHN | 1 | W 7-1 | 1-0 | 2 | 48,156 | Darryl Kile | Kevin Tapani | Darryl Kile | Kevin Tapani | | 7 | 1 | 6 |
| 2000-04-05 | vs CHN | 2 | W 10-4 | 2-0 | 2 | 38,908 | Pat Hentgen | Jon Lieber | Pat Hentgen | Jon Lieber | | 17 | 5 | 12 |
| 2000-04-06 | vs CHN | 3 | W 13-3 | 3-0 | 1 | 40,589 | Garrett Stephenson | Kyle Farnsworth | Garrett Stephenson | Kyle Farnsworth | | 30 | 8 | 22 |
| 2000-04-07 | vs MIL | 4 | L 1-9 | 3-1 | 1 | 33,089 | Andy Benes | Jason Bere | Jason Bere | Andy Benes | | 31 | 17 | 14 |
| 2000-04-08 | vs MIL | 5 | W 10-8 | 4-1 | 1 | 40,909 | Darryl Kile | Steve Woodard | Darryl Kile | Steve Woodard | Dave Veres | 41 | 25 | 16 |
| 2000-04-09 | vs MIL | 6 | W 11-2 | 5-1 | 1 | 48,082 | Rick Ankiel | Valerio de los Santos | Rick Ankiel | Valerio de los Santos | | 52 | 27 | 25 |
| 2000-04-10 | @ HOU | 7 | W 8-7 | 6-1 | 1 | 36,324 | Pat Hentgen | Jose Lima | Pat Hentgen | Jose Lima | Dave Veres | 60 | 34 | 26 |
| 2000-04-11 | @ HOU | 8 | W 10-6 | 7-1 | 1 | 37,463 | Garrett Stephenson | Chris Holt | Garrett Stephenson | Chris Holt | | 70 | 40 | 30 |
| 2000-04-12 | @ HOU | 9 | L 5-7 | 7-2 | 1 | 38,783 | Andy Benes | Octavio Dotel | Yorkis Perez | Dave Wainhouse | Billy Wagner | 75 | 47 | 28 |
| 2000-04-13 | @ COL | 10 | L 6-12 | 7-3 | 1 | 39,365 | Darryl Kile | Scott Karl | Rich Croushore | Darryl Kile | | 81 | 59 | 22 |
| 2000-04-14 | @ COL | 11 | L 2-6 | 7-4 | 1 | 40,248 | Rick Ankiel | Pedro Astacio | Pedro Astacio | Rick Ankiel | | 83 | 65 | 18 |
| 2000-04-16 | @ COL | 12 | W 9-3 | 8-5 | 1 | 43,029 | Pat Hentgen | Rolando Arrojo | Pat Hentgen | Rolando Arrojo | | 92 | 68 | 24 |
| 2000-04-16 | @ COL | 13 | L 13-14 | 8-5 | 1 | 35,095 | Garrett Stephenson | Brian Bohanon | Jose Jimenez | Mike Mohler | Gabe White | 105 | 82 | 23 |
| 2000-04-18 | vs SDN | 14 | W 5-4 | 9-5 | 1 | 32,062 | Andy Benes | Brian Meadows | Andy Benes | Brian Meadows | Dave Veres | 110 | 86 | 24 |
| 2000-04-19 | vs SDN | 15 | W 4-3 | 10-5 | 1 | 27,997 | Darryl Kile | Sterling Hitchcock | Darryl Kile | Sterling Hitchcock | Dave Veres | 114 | 89 | 25 |
| 2000-04-20 | vs SDN | 16 | W 14-1 | 11-5 | 1 | 32,510 | Rick Ankiel | Brian Boehringer | Rick Ankiel | Brian Boehringer | | 128 | 90 | 38 |
| 2000-04-21 | vs COL | 17 | L 4-6 | 11-6 | 1 | 34,966 | Pat Hentgen | Kevin Jarvis | Kevin Jarvis | Pat Hentgen | Jose Jimenez | 132 | 96 | 36 |
| 2000-04-22 | vs COL | 18 | L 6-7 | 11-7 | 1 | 42,901 | Garrett Stephenson | Masato Yoshii | Rich Croushore | Mike James | Jose Jimenez | 138 | 103 | 35 |
| 2000-04-23 | vs COL | 19 | W 6-3 | 12-7 | 1 | 30,253 | Andy Benes | Scott Karl | Andy Benes | Scott Karl | Heathcliff Slocumb | 144 | 106 | 38 |
| 2000-04-25 | vs MIL | 20 | W 7-2 | 13-7 | 1 | 28,232 | Darryl Kile | Jason Bere | Darryl Kile | Jason Bere | | 151 | 108 | 43 |
| 2000-04-26 | vs MIL | 21 | W 7-0 | 14-7 | 1 | 29,890 | Rick Ankiel | Steve Woodard | Rick Ankiel | Steve Woodard | | 158 | 108 | 50 |
| 2000-04-27 | vs MIL | 22 | L 4-8 | 14-8 | 1 | 34,572 | Pat Hentgen | Jimmy Haynes | Jimmy Haynes | Pat Hentgen | | 162 | 116 | 46 |
| 2000-04-28 | @ PHI | 23 | W 7-4 | 15-8 | 1 | 25,877 | Garrett Stephenson | Robert Person | Garrett Stephenson | Carlos Reyes | Dave Veres | 169 | 120 | 49 |
| 2000-04-29 | @ PHI | 24 | W 7-6 | 16-8 | 1 | 23,031 | Andy Benes | Randy Wolf | Mike Mohler | Wayne Gomes | | 176 | 126 | 50 |
| 2000-04-30 | @ PHI | 25 | W 4-3 | 17-8 | 1 | 34,033 | Darryl Kile | Curt Schilling | Darryl Kile | Curt Schilling | Mike James | 180 | 129 | 51 |
| 2000-05-02 | vs PIT | 26 | L 7-10 | 17-9 | 1 | 38,588 | Rick Ankiel | Jason Schmidt | Jeff Wallace | Heathcliff Slocumb | | 187 | 139 | 48 |
| 2000-05-03 | vs PIT | 27 | L 2-8 | 17-10 | 1 | 32,270 | Pat Hentgen | Kris Benson | Kris Benson | Pat Hentgen | | 189 | 147 | 42 |
| 2000-05-04 | vs PIT | 28 | W 5-0 | 18-10 | 1 | 45,994 | Garrett Stephenson | Francisco Cordova | Garrett Stephenson | Francisco Cordova | | 194 | 147 | 47 |
| 2000-05-05 | @ CIN | 29 | L 2-3 | 18-11 | 1 | 42,126 | Andy Benes | Ron Villone | Ron Villone | Andy Benes | Scott Williamson | 196 | 150 | 46 |
| 2000-05-06 | @ CIN | 30 | W 3-1 | 19-11 | 1 | 46,550 | Darryl Kile | Rob Bell | Darryl Kile | Rob Bell | Dave Veres | 199 | 151 | 48 |
| 2000-05-07 | @ CIN | 31 | L 7-9 | 19-12 | 1 | 42,221 | Rick Ankiel | Denny Neagle | Denny Neagle | Darren Holmes | Scott Williamson | 206 | 160 | 46 |
| 2000-05-08 | @ SFN | 32 | L 4-6 | 19-13 | 1 | 40,930 | Pat Hentgen | Livan Hernandez | Livan Hernandez | Pat Hentgen | Robb Nen | 210 | 166 | 44 |
| 2000-05-09 | @ SFN | 33 | W 13-6 | 20-13 | 1 | 40,930 | Garrett Stephenson | Russ Ortiz | Garrett Stephenson | Russ Ortiz | | 223 | 172 | 51 |
| 2000-05-10 | @ SFN | 34 | L 3-4 | 20-14 | 1 | 40,930 | Andy Benes | Kirk Rueter | Felix Rodriguez | Heathcliff Slocumb | Robb Nen | 226 | 176 | 50 |
| 2000-05-12 | vs LAN | 35 | L 0-13 | 20-15 | 2 | 44,975 | Darryl Kile | Darren Dreifort | Darren Dreifort | Darryl Kile | | 226 | 189 | 37 |
| 2000-05-13 | vs LAN | 36 | L 1-3 | 20-16 | 2 | 48,372 | Rick Ankiel | Chan Ho Park | Chan Ho Park | Dave Veres | Jeff Shaw | 227 | 192 | 35 |
| 2000-05-14 | vs LAN | 37 | W 12-10 | 21-16 | 2 | 45,151 | Pat Hentgen | Carlos Perez | Heathcliff Slocumb | Carlos Perez | Dave Veres | 239 | 202 | 37 |
| 2000-05-16 | @ PHI | 38 | W 8-2 | 22-16 | 2 | 18,399 | Andy Benes | Robert Person | Andy Benes | Robert Person | | 247 | 204 | 43 |
| 2000-05-17 | @ PHI | 39 | L 4-5 | 22-17 | 2 | 18,941 | Darryl Kile | Randy Wolf | Randy Wolf | Heathcliff Slocumb | Jeff Brantley | 251 | 209 | 42 |
| 2000-05-18 | @ PHI | 40 | W 7-2 | 23-17 | 2 | 17,137 | Garrett Stephenson | Curt Schilling | Garrett Stephenson | Curt Schilling | | 258 | 211 | 47 |
| 2000-05-19 | @ PIT | 41 | L 1-13 | 23-18 | 2 | 24,281 | Rick Ankiel | Kris Benson | Kris Benson | Rick Ankiel | | 259 | 224 | 35 |
| 2000-05-20 | @ PIT | 42 | W 19-4 | 24-18 | 2 | 36,331 | Pat Hentgen | Francisco Cordova | Pat Hentgen | Francisco Cordova | | 278 | 228 | 50 |
| 2000-05-21 | @ PIT | 43 | W 7-5 | 25-18 | 1 | 33,034 | Andy Benes | Todd Ritchie | Andy Benes | Todd Ritchie | Dave Veres | 285 | 233 | 52 |
| 2000-05-23 | vs FLO | 44 | W 10-3 | 26-18 | 1 | 37,495 | Darryl Kile | Ryan Dempster | Darryl Kile | Ryan Dempster | | 295 | 236 | 59 |
| 2000-05-24 | vs FLO | 45 | W 5-1 | 27-18 | 1 | 34,105 | Garrett Stephenson | Vladimir Nunez | Garrett Stephenson | Vladimir Nunez | | 300 | 237 | 63 |
| 2000-05-25 | vs FLO | 46 | W 7-6 | 28-18 | 1 | 44,337 | Rick Ankiel | Reid Cornelius | Rick Ankiel | Reid Cornelius | Dave Veres | 307 | 243 | 64 |
| 2000-05-26 | vs NYN | 47 | L 2-5 | 28-19 | 1 | 40,028 | Pat Hentgen | Mike Hampton | Mike Hampton | Mark Thompson | Armando Benitez | 309 | 248 | 61 |
| 2000-05-27 | vs NYN | 48 | L 8-12 | 28-20 | 1 | 48,690 | Andy Benes | Rick Reed | Dennis Cook | Dave Veres | | 317 | 260 | 57 |
| 2000-05-28 | vs NYN | 49 | L 2-6 | 28-21 | 1 | 46,344 | Darryl Kile | Glendon Rusch | Glendon Rusch | Darryl Kile | | 319 | 266 | 53 |
| 2000-05-29 | @ ARI | 50 | W 3-0 | 29-21 | 1 | 47,014 | Garrett Stephenson | Todd Stottlemyre | Garrett Stephenson | Todd Stottlemyre | | 322 | 266 | 56 |
| 2000-05-30 | @ ARI | 51 | W 6-1 | 30-21 | 1 | 36,180 | Rick Ankiel | Omar Daal | Rick Ankiel | Omar Daal | Matt Morris | 328 | 267 | 61 |
| 2000-05-31 | @ ARI | 52 | L 2-6 | 30-22 | 1 | 39,761 | Pat Hentgen | Randy Johnson | Randy Johnson | Pat Hentgen | Byung-Hyun Kim | 330 | 273 | 57 |
| 2000-06-01 | @ ARI | 53 | L 0-4 | 30-23 | 1 | 37,131 | Andy Benes | Armando Reynoso | Armando Reynoso | Andy Benes | | 330 | 277 | 53 |
| 2000-06-02 | vs CLE | 54 | W 5-1 | 31-23 | 1 | 41,685 | Darryl Kile | Jaret Wright | Darryl Kile | Jaret Wright | | 335 | 278 | 57 |
| 2000-06-03 | vs CLE | 55 | L 2-4 | 31-24 | 2 | 48,252 | Garrett Stephenson | Bartolo Colon | Bartolo Colon | Garrett Stephenson | Steve Karsay | 337 | 282 | 55 |
| 2000-06-04 | vs CLE | 56 | L 2-3 | 31-25 | 2 | 44,594 | Rick Ankiel | Jim Brower | Tom Martin | Matt Morris | Steve Karsay | 339 | 285 | 54 |
| 2000-06-05 | vs KCA | 57 | L 4-7 | 31-26 | 2 | 43,625 | Pat Hentgen | Mac Suzuki | Mac Suzuki | Pat Hentgen | Jerry Spradlin | 343 | 292 | 51 |
| 2000-06-06 | vs KCA | 58 | W 5-4 | 32-26 | 2 | 40,017 | Andy Benes | Chris Fussell | Andy Benes | Jay Witasick | Dave Veres | 348 | 296 | 52 |
| 2000-06-07 | vs KCA | 59 | W 4-2 | 33-26 | 1 | 37,444 | Darryl Kile | Miguel Batista | Darryl Kile | Miguel Batista | | 352 | 298 | 54 |
| 2000-06-09 | @ DET | 60 | L 2-4 | 33-27 | 1 | 39,081 | Garrett Stephenson | Jeff Weaver | Jeff Weaver | Garrett Stephenson | Todd Jones | 354 | 302 | 52 |
| 2000-06-10 | @ DET | 61 | L 1-10 | 33-28 | 1 | 39,053 | Rick Ankiel | Brian Moehler | Brian Moehler | Rick Ankiel | | 355 | 312 | 43 |
| 2000-06-11 | @ DET | 62 | W 7-3 | 34-28 | 1 | 38,139 | Pat Hentgen | Dave Mlicki | Pat Hentgen | Dave Mlicki | | 362 | 315 | 47 |
| 2000-06-12 | @ SDN | 63 | W 7-3 | 35-28 | 1 | 23,359 | Andy Benes | Matt Clement | Andy Benes | Matt Clement | | 369 | 318 | 51 |
| 2000-06-13 | @ SDN | 64 | W 8-3 | 36-28 | 1 | 29,055 | Darryl Kile | Rodrigo Lopez | Darryl Kile | Rodrigo Lopez | Dave Veres | 377 | 321 | 56 |
| 2000-06-14 | @ SDN | 65 | W 3-1 | 37-28 | 1 | 30,952 | Garrett Stephenson | Stan Spencer | Garrett Stephenson | Stan Spencer | Matt Morris | 380 | 322 | 58 |
| 2000-06-16 | @ LAN | 66 | W 6-3 | 38-28 | 1 | 43,971 | Pat Hentgen | Orel Hershiser | Pat Hentgen | Orel Hershiser | Dave Veres | 386 | 325 | 61 |
| 2000-06-17 | @ LAN | 67 | W 4-3 | 39-28 | 1 | 46,048 | Andy Benes | Darren Dreifort | Andy Benes | Darren Dreifort | Dave Veres | 390 | 328 | 62 |
| 2000-06-18 | @ LAN | 68 | L 3-6 | 39-29 | 1 | 50,713 | Darryl Kile | Chan Ho Park | Chan Ho Park | Darryl Kile | Jeff Shaw | 393 | 334 | 59 |
| 2000-06-20 | vs SFN | 69 | W 7-2 | 40-29 | 1 | 38,939 | Rick Ankiel | Russ Ortiz | Rick Ankiel | Russ Ortiz | | 400 | 336 | 64 |
| 2000-06-21 | vs SFN | 70 | L 1-4 | 40-30 | 1 | 37,341 | Garrett Stephenson | Kirk Rueter | Kirk Rueter | Garrett Stephenson | Robb Nen | 401 | 340 | 61 |
| 2000-06-22 | vs SFN | 71 | W 11-10 | 41-30 | 1 | 36,192 | Pat Hentgen | Shawn Estes | Dave Veres | Mark Gardner | | 412 | 350 | 62 |
| 2000-06-23 | vs LAN | 72 | W 9-6 | 42-30 | 1 | 48,395 | Andy Benes | Chan Ho Park | Gene Stechschulte | Jeff Shaw | | 421 | 356 | 65 |
| 2000-06-24 | vs LAN | 73 | W 6-1 | 43-30 | 1 | 47,071 | Darryl Kile | Orel Hershiser | Alan Benes | Orel Hershiser | | 427 | 357 | 70 |
| 2000-06-25 | vs LAN | 74 | W 2-1 | 44-30 | 1 | 47,062 | Rick Ankiel | Kevin Brown | Heathcliff Slocumb | Antonio Osuna | | 429 | 358 | 71 |
| 2000-06-26 | @ CIN | 75 | L 2-3 | 44-31 | 1 | 32,850 | Garrett Stephenson | Denny Neagle | Denny Neagle | Garrett Stephenson | Danny Graves | 431 | 361 | 70 |
| 2000-06-27 | @ CIN | 76 | W 4-3 | 45-31 | 1 | 33,946 | Darryl Kile | Steve Parris | Darryl Kile | Steve Parris | Dave Veres | 435 | 364 | 71 |
| 2000-06-28 | @ CIN | 77 | L 3-7 | 45-32 | 1 | 37,861 | Pat Hentgen | Elmer Dessens | Dennys Reyes | Alan Benes | | 438 | 371 | 67 |
| 2000-06-29 | @ CIN | 78 | W 12-3 | 46-32 | 1 | 45,771 | Andy Benes | Ron Villone | Andy Benes | Ron Villone | | 450 | 374 | 76 |
| 2000-06-30 | vs HOU | 79 | W 5-4 | 47-32 | 1 | 46,262 | Rick Ankiel | Chris Holt | Alan Benes | Chris Holt | Dave Veres | 455 | 378 | 77 |
| 2000-07-01 | vs HOU | 80 | W 10-9 | 48-32 | 1 | 47,675 | Garrett Stephenson | Octavio Dotel | Mark Thompson | Joe Slusarski | Dave Veres | 465 | 387 | 78 |
| 2000-07-02 | vs HOU | 81 | L 3-6 | 48-33 | 1 | 44,796 | Darryl Kile | Scott Elarton | Scott Elarton | Darryl Kile | Marc Valdes | 468 | 393 | 75 |
| 2000-07-04 | vs CIN | 82 | W 14-3 | 49-33 | 1 | 46,022 | Andy Benes | Ron Villone | Andy Benes | Ron Villone | | 482 | 396 | 86 |
| 2000-07-05 | vs CIN | 83 | W 4-3 | 50-33 | 1 | 45,269 | Pat Hentgen | Pete Harnisch | Pat Hentgen | Pete Harnisch | Dave Veres | 486 | 399 | 87 |
| 2000-07-06 | vs CIN | 84 | L 6-12 | 50-34 | 1 | 43,287 | Rick Ankiel | Osvaldo Fernandez | Elmer Dessens | Rick Ankiel | | 492 | 411 | 81 |
| 2000-07-07 | vs SFN | 85 | L 2-4 | 50-35 | 1 | 46,738 | Darryl Kile | Kirk Rueter | Alan Embree | Matt Morris | Robb Nen | 494 | 415 | 79 |
| 2000-07-08 | vs SFN | 86 | L 6-7 | 50-36 | 1 | 47,227 | Garrett Stephenson | Shawn Estes | Shawn Estes | Garrett Stephenson | Robb Nen | 500 | 422 | 78 |
| 2000-07-09 | vs SFN | 87 | W 8-7 | 51-36 | 1 | 44,202 | Pat Hentgen | Livan Hernandez | Pat Hentgen | Livan Hernandez | Dave Veres | 508 | 429 | 79 |
| 2000-07-13 | @ CHA | 88 | W 13-5 | 52-36 | 1 | 32,263 | Andy Benes | Mike Sirotka | Andy Benes | Mike Sirotka | | 521 | 434 | 87 |
| 2000-07-14 | @ CHA | 89 | W 9-4 | 53-36 | 1 | 34,862 | Garrett Stephenson | Cal Eldred | Garrett Stephenson | Kelly Wunsch | | 530 | 438 | 92 |
| 2000-07-15 | @ CHA | 90 | L 7-15 | 53-37 | 1 | 40,681 | Darryl Kile | Jim Parque | Jim Parque | Darryl Kile | | 537 | 453 | 84 |
| 2000-07-16 | @ MIN | 91 | L 2-5 | 53-38 | 1 | 30,116 | Rick Ankiel | Mark Redman | Mark Redman | Rick Ankiel | Eddie Guardado | 539 | 458 | 81 |
| 2000-07-17 | @ MIN | 92 | W 8-3 | 54-38 | 1 | 20,171 | Pat Hentgen | Mike Lincoln | Pat Hentgen | Mike Lincoln | | 547 | 461 | 86 |
| 2000-07-18 | @ MIN | 93 | L 2-3 | 54-39 | 1 | 18,115 | Andy Benes | Brad Radke | Brad Radke | Andy Benes | LaTroy Hawkins | 549 | 464 | 85 |
| 2000-07-19 | @ ARI | 94 | L 3-4 | 54-40 | 1 | 37,119 | Garrett Stephenson | Armando Reynoso | Armando Reynoso | Garrett Stephenson | Matt Mantei | 552 | 468 | 84 |
| 2000-07-20 | @ ARI | 95 | L 2-3 | 54-41 | 1 | 40,937 | Darryl Kile | Randy Johnson | Randy Johnson | Dave Veres | | 554 | 471 | 83 |
| 2000-07-21 | @ HOU | 96 | W 12-1 | 55-41 | 1 | 42,811 | Rick Ankiel | Scott Elarton | Rick Ankiel | Scott Elarton | | 566 | 472 | 94 |
| 2000-07-22 | @ HOU | 97 | L 5-10 | 55-42 | 1 | 42,588 | Pat Hentgen | Wade Miller | Wade Miller | Pat Hentgen | | 571 | 482 | 89 |
| 2000-07-23 | @ HOU | 98 | L 7-15 | 55-43 | 1 | 42,684 | Andy Benes | Shane Reynolds | Shane Reynolds | Andy Benes | | 578 | 497 | 81 |
| 2000-07-25 | vs ARI | 99 | W 7-3 | 56-43 | 1 | 44,454 | Garrett Stephenson | Randy Johnson | Garrett Stephenson | Randy Johnson | | 585 | 500 | 85 |
| 2000-07-26 | vs ARI | 100 | W 8-4 | 57-43 | 1 | 42,762 | Darryl Kile | Armando Reynoso | Darryl Kile | Armando Reynoso | | 593 | 504 | 89 |
| 2000-07-27 | vs ARI | 101 | L 5-17 | 57-44 | 1 | 42,963 | Rick Ankiel | Geraldo Guzman | Geraldo Guzman | Rick Ankiel | | 598 | 521 | 77 |
| 2000-07-28 | @ NYN | 102 | L 2-3 | 57-45 | 1 | 42,396 | Pat Hentgen | Al Leiter | Al Leiter | Pat Hentgen | Armando Benitez | 600 | 524 | 76 |
| 2000-07-29 | @ NYN | 103 | L 3-4 | 57-46 | 1 | 50,726 | Andy Benes | Rick Reed | Rick White | Mike James | Armando Benitez | 603 | 528 | 75 |
| 2000-07-30 | @ NYN | 104 | L 2-4 | 57-47 | 1 | 45,733 | Garrett Stephenson | Robert Joseph Jones | Robert Joseph Jones | Garrett Stephenson | | 605 | 532 | 73 |
| 2000-07-31 | @ MON | 105 | W 4-0 | 58-47 | 1 | 9,558 | Darryl Kile | Mike Thurman | Darryl Kile | Mike Thurman | | 609 | 532 | 77 |
| 2000-08-01 | @ MON | 106 | L 0-4 | 58-48 | 1 | 9,818 | Rick Ankiel | Trey Moore | Trey Moore | Rick Ankiel | | 609 | 536 | 73 |
| 2000-08-02 | @ MON | 107 | W 10-7 | 59-48 | 1 | 9,669 | Pat Hentgen | Mike Johnson | Pat Hentgen | Mike Johnson | | 619 | 543 | 76 |
| 2000-08-04 | vs ATL | 108 | L 4-6 | 59-49 | 1 | 48,901 | Andy Benes | Tom Glavine | Tom Glavine | Andy Benes | Scott Kamieniecki | 623 | 549 | 74 |
| 2000-08-05 | vs ATL | 109 | W 5-0 | 60-49 | 1 | 47,709 | Garrett Stephenson | John Burkett | Garrett Stephenson | John Burkett | | 628 | 549 | 79 |
| 2000-08-06 | vs ATL | 110 | L 4-6 | 60-50 | 1 | 47,623 | Darryl Kile | Kevin Millwood | Mike Remlinger | Darryl Kile | Kerry Ligtenberg | 632 | 555 | 77 |
| 2000-08-07 | vs FLO | 111 | W 2-1 | 61-50 | 1 | 40,377 | Rick Ankiel | Reid Cornelius | Mike Timlin | Vic Darensbourg | | 634 | 556 | 78 |
| 2000-08-08 | vs FLO | 112 | L 0-7 | 61-51 | 1 | 39,407 | Pat Hentgen | Jesus Sanchez | Jesus Sanchez | Pat Hentgen | | 634 | 563 | 71 |
| 2000-08-09 | vs FLO | 113 | L 3-5 | 61-52 | 1 | 41,187 | Andy Benes | Ryan Dempster | Armando Almanza | Matt Morris | Antonio Alfonseca | 637 | 568 | 69 |
| 2000-08-10 | vs COL | 114 | W 5-4 | 62-52 | 1 | 44,020 | Garrett Stephenson | Pedro Astacio | Mike Timlin | Jose Jimenez | | 642 | 572 | 70 |
| 2000-08-11 | @ MIL | 115 | L 2-6 | 62-53 | 1 | 25,890 | Darryl Kile | Jeff D'Amico | Jeff D'Amico | Darryl Kile | | 644 | 578 | 66 |
| 2000-08-12 | @ MIL | 116 | W 2-1 | 63-53 | 1 | 31,502 | Rick Ankiel | Jimmy Haynes | Matt Morris | Curt Leskanic | Mike James | 646 | 579 | 67 |
| 2000-08-13 | @ MIL | 117 | W 6-4 | 64-53 | 1 | 33,496 | Pat Hentgen | Jamey Wright | Pat Hentgen | Jamey Wright | Dave Veres | 652 | 583 | 69 |
| 2000-08-14 | @ CHN | 118 | L 3-7 | 64-54 | 1 | 39,124 | Andy Benes | Jon Lieber | Jon Lieber | Andy Benes | | 655 | 590 | 65 |
| 2000-08-15 | @ CHN | 119 | W 4-2 | 65-54 | 1 | 38,231 | Garrett Stephenson | Jamie Arnold | Garrett Stephenson | Jamie Arnold | Dave Veres | 659 | 592 | 67 |
| 2000-08-16 | @ CHN | 120 | W 5-1 | 66-54 | 1 | 38,862 | Darryl Kile | Kevin Tapani | Darryl Kile | Kevin Tapani | | 664 | 593 | 71 |
| 2000-08-18 | vs PHI | 121 | W 7-6 | 67-54 | 1 | 46,253 | Rick Ankiel | Robert Person | Jason Christiansen | Chris Brock | | 671 | 599 | 72 |
| 2000-08-19 | vs PHI | 122 | W 6-3 | 68-54 | 1 | 47,163 | Pat Hentgen | Omar Daal | Pat Hentgen | Omar Daal | | 677 | 602 | 75 |
| 2000-08-20 | vs PHI | 123 | L 0-6 | 68-55 | 1 | 43,000 | Britt Reames | Kent Bottenfield | Kent Bottenfield | Britt Reames | | 677 | 608 | 69 |
| 2000-08-21 | vs PIT | 124 | W 7-4 | 69-55 | 1 | 35,644 | Garrett Stephenson | Kris Benson | Garrett Stephenson | Kris Benson | Dave Veres | 684 | 612 | 72 |
| 2000-08-22 | vs PIT | 125 | L 2-6 | 69-56 | 1 | 31,534 | Darryl Kile | Dan Serafini | Josias Manzanillo | Darryl Kile | | 686 | 618 | 68 |
| 2000-08-23 | vs PIT | 126 | W 5-2 | 70-56 | 1 | 31,288 | Rick Ankiel | Todd Ritchie | Rick Ankiel | Todd Ritchie | Dave Veres | 691 | 620 | 71 |
| 2000-08-24 | @ ATL | 127 | W 12-5 | 71-56 | 1 | 41,166 | Pat Hentgen | Andy Ashby | Pat Hentgen | Andy Ashby | | 703 | 625 | 78 |
| 2000-08-25 | @ ATL | 128 | L 4-7 | 71-57 | 1 | 46,695 | Britt Reames | Tom Glavine | Tom Glavine | Mike Timlin | Kerry Ligtenberg | 707 | 632 | 75 |
| 2000-08-26 | @ ATL | 129 | W 6-3 | 72-57 | 1 | 49,475 | Garrett Stephenson | Kevin Millwood | Garrett Stephenson | Kevin Millwood | | 713 | 635 | 78 |
| 2000-08-27 | @ ATL | 130 | W 7-2 | 73-57 | 1 | 46,574 | Darryl Kile | John Burkett | Darryl Kile | Kerry Ligtenberg | | 720 | 637 | 83 |
| 2000-08-28 | @ FLO | 131 | W 5-2 | 74-57 | 1 | 14,724 | Rick Ankiel | A.J. Burnett | Mike James | Armando Almanza | Dave Veres | 725 | 639 | 86 |
| 2000-08-29 | @ FLO | 132 | L 1-3 | 74-58 | 1 | 15,220 | Pat Hentgen | Chuck Smith | Chuck Smith | Pat Hentgen | Antonio Alfonseca | 726 | 642 | 84 |
| 2000-08-30 | @ FLO | 133 | W 4-2 | 75-58 | 1 | 13,681 | Britt Reames | Reid Cornelius | Matt Morris | Antonio Alfonseca | Dave Veres | 730 | 644 | 86 |
| 2000-09-01 | vs NYN | 134 | W 6-5 | 76-58 | 1 | 39,056 | Garrett Stephenson | Robert Joseph Jones | Dave Veres | Pat Mahomes | | 736 | 649 | 87 |
| 2000-09-02 | vs NYN | 135 | W 2-1 | 77-58 | 1 | 41,483 | Darryl Kile | Mike Hampton | Darryl Kile | Mike Hampton | | 738 | 650 | 88 |
| 2000-09-03 | vs NYN | 136 | W 4-3 | 78-58 | 1 | 42,133 | Rick Ankiel | Glendon Rusch | Matt Morris | Rick White | | 742 | 653 | 89 |
| 2000-09-04 | vs MON | 137 | W 4-2 | 79-58 | 1 | 39,704 | Pat Hentgen | Javier Vazquez | Pat Hentgen | Javier Vazquez | Dave Veres | 746 | 655 | 91 |
| 2000-09-05 | vs MON | 138 | W 7-6 | 80-58 | 1 | 31,821 | Britt Reames | Julio Santana | Britt Reames | Julio Santana | Mike Timlin | 753 | 661 | 92 |
| 2000-09-06 | vs MON | 139 | L 2-7 | 80-59 | 1 | 30,280 | Garrett Stephenson | Dustin Hermanson | Dustin Hermanson | Garrett Stephenson | | 755 | 668 | 87 |
| 2000-09-07 | vs MON | 140 | W 6-1 | 81-59 | 1 | 30,799 | Darryl Kile | Tony Armas | Darryl Kile | Tony Armas | | 761 | 669 | 92 |
| 2000-09-08 | @ MIL | 141 | L 5-6 | 81-60 | 1 | 21,664 | Rick Ankiel | Jeff D'Amico | Curt Leskanic | Dave Veres | | 766 | 675 | 91 |
| 2000-09-09 | @ MIL | 142 | W 7-6 | 82-60 | 1 | 25,095 | Pat Hentgen | Jimmy Haynes | Dave Veres | Juan Acevedo | | 773 | 681 | 92 |
| 2000-09-10 | @ MIL | 143 | L 3-4 | 82-61 | 1 | 31,528 | Britt Reames | Jamey Wright | Ray King | Andy Benes | | 776 | 685 | 91 |
| 2000-09-11 | @ PIT | 144 | W 8-4 | 83-61 | 1 | 16,583 | Garrett Stephenson | Jose Silva | Garrett Stephenson | Josias Manzanillo | | 784 | 689 | 95 |
| 2000-09-12 | @ PIT | 145 | W 11-1 | 84-61 | 1 | 15,824 | Darryl Kile | Dan Serafini | Darryl Kile | Dan Serafini | | 795 | 690 | 105 |
| 2000-09-13 | @ PIT | 146 | W 9-5 | 85-61 | 1 | 22,236 | Rick Ankiel | Todd Ritchie | Rick Ankiel | Todd Ritchie | | 804 | 695 | 109 |
| 2000-09-14 | vs CHN | 147 | W 4-0 | 86-61 | 1 | 41,493 | Pat Hentgen | Ruben Quevedo | Pat Hentgen | Ruben Quevedo | | 808 | 695 | 113 |
| 2000-09-15 | vs CHN | 148 | W 3-2 | 87-61 | 1 | 47,186 | Britt Reames | Jon Lieber | Mike James | Jon Lieber | Dave Veres | 811 | 697 | 114 |
| 2000-09-16 | vs CHN | 149 | W 7-6 | 88-61 | 1 | 47,461 | Garrett Stephenson | Daniel Garibay | Mike Timlin | Jerry Spradlin | Dave Veres | 818 | 703 | 115 |
| 2000-09-17 | vs CHN | 150 | W 4-2 | 89-61 | 1 | 46,910 | Darryl Kile | Kerry Wood | Darryl Kile | Tim Worrell | Matt Morris | 822 | 705 | 117 |
| 2000-09-19 | vs HOU | 151 | L 6-8 | 89-62 | 1 | 39,155 | Pat Hentgen | Wade Miller | Octavio Dotel | Alan Benes | Jose Cabrera | 828 | 713 | 115 |
| 2000-09-20 | vs HOU | 152 | W 11-6 | 90-62 | 1 | 38,653 | Rick Ankiel | Chris Holt | Rick Ankiel | Chris Holt | | 839 | 719 | 120 |
| 2000-09-21 | vs HOU | 153 | L 5-7 | 90-63 | 1 | 33,730 | Andy Benes | Tony McKnight | Tony McKnight | Andy Benes | Octavio Dotel | 844 | 726 | 118 |
| 2000-09-22 | @ CHN | 154 | L 4-5 | 90-64 | 1 | 36,732 | Darryl Kile | Kerry Wood | Will Ohman | Dave Veres | | 848 | 731 | 117 |
| 2000-09-23 | @ CHN | 155 | W 6-5 | 91-64 | 1 | 38,168 | Britt Reames | Joey Nation | Britt Reames | Joey Nation | Matt Morris | 854 | 736 | 118 |
| 2000-09-24 | @ CHN | 156 | L 5-10 | 91-65 | 1 | 36,887 | Pat Hentgen | Todd Van Poppel | Todd Van Poppel | Pat Hentgen | Felix Heredia | 859 | 746 | 113 |
| 2000-09-26 | @ SDN | 157 | W 7-1 | 92-65 | 1 | 29,722 | Andy Benes | Adam Eaton | Andy Benes | Adam Eaton | | 866 | 747 | 119 |
| 2000-09-27 | @ SDN | 158 | W 3-0 | 93-65 | 1 | 28,500 | Rick Ankiel | Brian Tollberg | Rick Ankiel | Brian Tollberg | Dave Veres | 869 | 747 | 122 |
| 2000-09-28 | @ SDN | 159 | W 7-6 | 94-65 | 1 | 30,093 | Darryl Kile | Jay Witasick | Darryl Kile | Tom Davey | Dave Veres | 876 | 753 | 123 |
| 2000-09-29 | vs CIN | 160 | L 1-8 | 94-66 | 1 | 46,152 | Garrett Stephenson | Ron Villone | Ron Villone | Garrett Stephenson | | 877 | 761 | 116 |
| 2000-09-30 | vs CIN | 161 | L 4-8 | 94-67 | 1 | 47,099 | Pat Hentgen | Osvaldo Fernandez | Osvaldo Fernandez | Pat Hentgen | | 881 | 769 | 112 |
| 2000-10-01 | vs CIN | 162 | W 6-2 | 95-67 | 1 | 47,533 | Andy Benes | Steve Parris | Andy Benes | Steve Parris | | 887 | 771 | 116 |