| 2000-04-03 | @ FLO | 1 | L 4-6 | 0-1 | 5 | 35,101 | Livan Hernandez | Alex Fernandez | Alex Fernandez | Livan Hernandez | Antonio Alfonseca | 4 | 6 | -2 |
| 2000-04-04 | @ FLO | 2 | W 3-0 | 1-1 | 4 | 9,524 | Russ Ortiz | Ryan Dempster | Russ Ortiz | Ryan Dempster | Robb Nen | 7 | 6 | 1 |
| 2000-04-05 | @ FLO | 3 | W 11-9 | 2-1 | 3 | 8,365 | Kirk Rueter | Vladimir Nunez | John Johnstone | Antonio Alfonseca | Robb Nen | 18 | 15 | 3 |
| 2000-04-06 | @ FLO | 4 | L 4-5 | 2-2 | 4 | 7,741 | Joe Nathan | Jesus Sanchez | Dan Miceli | John Johnstone | | 22 | 20 | 2 |
| 2000-04-07 | @ ATL | 5 | W 6-2 | 3-2 | 3 | 35,343 | Mark Gardner | Terry Mulholland | Mark Gardner | Terry Mulholland | | 28 | 22 | 6 |
| 2000-04-08 | @ ATL | 6 | L 5-7 | 3-3 | 4 | 35,938 | Livan Hernandez | Greg Maddux | Greg Maddux | Livan Hernandez | Kerry Ligtenberg | 33 | 29 | 4 |
| 2000-04-09 | @ ATL | 7 | L 3-9 | 3-4 | 4 | 32,654 | Russ Ortiz | Tom Glavine | Tom Glavine | Russ Ortiz | | 36 | 38 | -2 |
| 2000-04-11 | vs LAN | 8 | L 5-6 | 3-5 | 5 | 40,930 | Kirk Rueter | Chan Ho Park | Chan Ho Park | Kirk Rueter | Jeff Shaw | 41 | 44 | -3 |
| 2000-04-12 | vs LAN | 9 | L 5-6 | 3-6 | 5 | 40,390 | Joe Nathan | Darren Dreifort | Terry Adams | Ben Weber | Jeff Shaw | 46 | 50 | -4 |
| 2000-04-13 | vs LAN | 10 | L 7-11 | 3-7 | 5 | 40,930 | Mark Gardner | Carlos Perez | Carlos Perez | Mark Gardner | Jeff Shaw | 53 | 61 | -8 |
| 2000-04-14 | vs ARI | 11 | L 1-3 | 3-8 | 5 | 40,930 | Livan Hernandez | Randy Johnson | Randy Johnson | Livan Hernandez | | 54 | 64 | -10 |
| 2000-04-15 | vs ARI | 12 | L 4-7 | 3-9 | 5 | 40,930 | Russ Ortiz | Todd Stottlemyre | Todd Stottlemyre | Russ Ortiz | Greg Swindell | 58 | 71 | -13 |
| 2000-04-18 | @ CIN | 13 | W 13-9 | 4-9 | 5 | 25,888 | Joe Nathan | Ron Villone | Kirk Rueter | Scott Williamson | | 71 | 80 | -9 |
| 2000-04-19 | @ CIN | 14 | L 4-5 | 4-10 | 5 | 22,795 | Shawn Estes | Rob Bell | Rob Bell | Shawn Estes | Danny Graves | 75 | 85 | -10 |
| 2000-04-20 | @ CIN | 15 | L 1-11 | 4-11 | 5 | 27,003 | Livan Hernandez | Denny Neagle | Denny Neagle | Livan Hernandez | | 76 | 96 | -20 |
| 2000-04-21 | @ ARI | 16 | W 11-5 | 5-11 | 5 | 40,929 | Russ Ortiz | Todd Stottlemyre | Russ Ortiz | Todd Stottlemyre | | 87 | 101 | -14 |
| 2000-04-22 | @ ARI | 17 | W 8-6 | 6-11 | 5 | 45,659 | Kirk Rueter | Omar Daal | Kirk Rueter | Omar Daal | Robb Nen | 95 | 107 | -12 |
| 2000-04-23 | @ ARI | 18 | W 12-7 | 7-11 | 5 | 35,879 | Joe Nathan | Armando Reynoso | Joe Nathan | Armando Reynoso | | 107 | 114 | -7 |
| 2000-04-25 | @ FLO | 19 | W 6-4 | 8-11 | 5 | 9,072 | Shawn Estes | Ryan Dempster | Mark Gardner | Dan Miceli | | 113 | 118 | -5 |
| 2000-04-26 | @ FLO | 20 | W 8-7 | 9-11 | 5 | 15,296 | Livan Hernandez | Vladimir Nunez | Aaron Fultz | Antonio Alfonseca | | 121 | 125 | -4 |
| 2000-04-28 | vs MON | 21 | L 3-9 | 9-12 | 5 | 40,930 | Russ Ortiz | Hideki Irabu | Anthony Telford | Russ Ortiz | | 124 | 134 | -10 |
| 2000-04-29 | vs MON | 22 | W 2-1 | 10-12 | 5 | 40,930 | Kirk Rueter | Javier Vazquez | John Johnstone | Anthony Telford | Robb Nen | 126 | 135 | -9 |
| 2000-04-30 | vs MON | 23 | L 3-4 | 10-13 | 5 | 40,930 | Joe Nathan | Carl Pavano | Scott Strickland | John Johnstone | Ugueth Urbina | 129 | 139 | -10 |
| 2000-05-01 | vs NYN | 24 | W 10-3 | 11-13 | 4 | 40,930 | Shawn Estes | Bill Pulsipher | Shawn Estes | Bill Pulsipher | | 139 | 142 | -3 |
| 2000-05-02 | vs NYN | 25 | W 7-1 | 12-13 | 4 | 40,930 | Livan Hernandez | Glendon Rusch | Livan Hernandez | Glendon Rusch | | 146 | 143 | 3 |
| 2000-05-03 | vs NYN | 26 | W 8-5 | 13-13 | 4 | 40,930 | Russ Ortiz | Mike Hampton | Felix Rodriguez | Turk Wendell | | 154 | 148 | 6 |
| 2000-05-04 | vs NYN | 27 | W 7-2 | 14-13 | 3 | 40,930 | Kirk Rueter | Rick Reed | Felix Rodriguez | Rick Reed | | 161 | 150 | 11 |
| 2000-05-05 | vs COL | 28 | W 5-0 | 15-13 | 3 | 40,930 | Joe Nathan | Masato Yoshii | Joe Nathan | Masato Yoshii | | 166 | 150 | 16 |
| 2000-05-06 | vs COL | 29 | W 6-0 | 16-13 | 3 | 40,930 | Shawn Estes | Rolando Arrojo | Shawn Estes | Rolando Arrojo | | 172 | 150 | 22 |
| 2000-05-08 | vs SLN | 30 | W 6-4 | 17-13 | 2 | 40,930 | Livan Hernandez | Pat Hentgen | Livan Hernandez | Pat Hentgen | Robb Nen | 178 | 154 | 24 |
| 2000-05-09 | vs SLN | 31 | L 6-13 | 17-14 | 2 | 40,930 | Russ Ortiz | Garrett Stephenson | Garrett Stephenson | Russ Ortiz | | 184 | 167 | 17 |
| 2000-05-10 | vs SLN | 32 | W 4-3 | 18-14 | 2 | 40,930 | Kirk Rueter | Andy Benes | Felix Rodriguez | Heathcliff Slocumb | Robb Nen | 188 | 170 | 18 |
| 2000-05-12 | @ COL | 33 | L 7-15 | 18-15 | 2 | 42,566 | Joe Nathan | Rolando Arrojo | Brian Bohanon | Joe Nathan | | 195 | 185 | 10 |
| 2000-05-13 | @ COL | 34 | L 9-10 | 18-16 | 3 | 44,829 | Shawn Estes | Pedro Astacio | Gabe White | John Johnstone | Jose Jimenez | 204 | 195 | 9 |
| 2000-05-14 | @ COL | 35 | L 7-11 | 18-17 | 3 | 44,577 | Livan Hernandez | Scott Karl | Gabe White | Livan Hernandez | | 211 | 206 | 5 |
| 2000-05-16 | @ ATL | 36 | L 7-9 | 18-18 | 4 | 35,808 | Russ Ortiz | Tom Glavine | Tom Glavine | Russ Ortiz | Terry Mulholland | 218 | 215 | 3 |
| 2000-05-17 | @ ATL | 37 | L 4-5 | 18-19 | 4 | 33,138 | Kirk Rueter | Kevin Millwood | Kevin Millwood | Kirk Rueter | Rudy Seanez | 222 | 220 | 2 |
| 2000-05-18 | @ ATL | 38 | L 2-3 | 18-20 | 4 | 42,222 | Shawn Estes | Greg Maddux | Greg Maddux | Shawn Estes | John Rocker | 224 | 223 | 1 |
| 2000-05-19 | @ MIL | 39 | L 10-11 | 18-21 | 4 | 12,842 | Livan Hernandez | Jimmy Haynes | Bob Wickman | Robb Nen | | 234 | 234 | 0 |
| 2000-05-20 | @ MIL | 40 | L 0-7 | 18-22 | 4 | 15,712 | Mark Gardner | Jeff D'Amico | Jeff D'Amico | Mark Gardner | | 234 | 241 | -7 |
| 2000-05-21 | @ MIL | 41 | W 16-10 | 19-22 | 4 | 20,571 | Russ Ortiz | John Snyder | Russ Ortiz | Hector Ramirez | | 250 | 251 | -1 |
| 2000-05-23 | vs MON | 42 | L 2-3 | 19-23 | 4 | 40,930 | Kirk Rueter | Carl Pavano | Carl Pavano | Kirk Rueter | Dustin Hermanson | 252 | 254 | -2 |
| 2000-05-24 | vs MON | 43 | W 18-0 | 20-23 | 4 | 40,930 | Shawn Estes | Mike Thurman | Shawn Estes | Mike Thurman | | 270 | 254 | 16 |
| 2000-05-25 | vs MON | 44 | W 4-1 | 21-23 | 4 | 40,930 | Livan Hernandez | Tony Armas | Livan Hernandez | Tony Armas | Robb Nen | 274 | 255 | 19 |
| 2000-05-26 | vs CHN | 45 | W 5-3 | 22-23 | 4 | 40,930 | Mark Gardner | Kevin Tapani | Mark Gardner | Kevin Tapani | | 279 | 258 | 21 |
| 2000-05-27 | vs CHN | 46 | L 2-3 | 22-24 | 4 | 40,930 | Russ Ortiz | Scott Downs | Daniel Garibay | Aaron Fultz | Rick Aguilera | 281 | 261 | 20 |
| 2000-05-28 | vs CHN | 47 | L 1-4 | 22-25 | 4 | 40,930 | Kirk Rueter | Kerry Wood | Kerry Wood | Kirk Rueter | Rick Aguilera | 282 | 265 | 17 |
| 2000-05-29 | vs PHI | 48 | W 7-2 | 23-25 | 4 | 40,930 | Shawn Estes | Curt Schilling | Shawn Estes | Curt Schilling | Alan Embree | 289 | 267 | 22 |
| 2000-05-30 | vs PHI | 49 | W 7-3 | 24-25 | 4 | 40,930 | Livan Hernandez | Andy Ashby | Livan Hernandez | Andy Ashby | Robb Nen | 296 | 270 | 26 |
| 2000-05-31 | vs PHI | 50 | W 10-4 | 25-25 | 4 | 40,930 | Mark Gardner | Paul Byrd | Mark Gardner | Paul Byrd | | 306 | 274 | 32 |
| 2000-06-02 | @ OAK | 51 | L 4-5 | 25-26 | 4 | 51,768 | Russ Ortiz | Mark Mulder | Mark Mulder | Russ Ortiz | Jason Isringhausen | 310 | 279 | 31 |
| 2000-06-03 | @ OAK | 52 | L 7-9 | 25-27 | 4 | 45,392 | Kirk Rueter | Tim Hudson | Doug Jones | Alan Embree | Jason Isringhausen | 317 | 288 | 29 |
| 2000-06-04 | @ OAK | 53 | W 18-2 | 26-27 | 4 | 48,128 | Shawn Estes | Omar Olivares | Shawn Estes | Omar Olivares | | 335 | 290 | 45 |
| 2000-06-05 | @ ANA | 54 | W 5-4 | 27-27 | 4 | 17,924 | Livan Hernandez | Scott Schoeneweis | Aaron Fultz | Shigetoshi Hasegawa | | 340 | 294 | 46 |
| 2000-06-06 | @ ANA | 55 | L 5-6 | 27-28 | 4 | 19,674 | Joe Nathan | Seth Etherton | Troy Percival | Robb Nen | | 345 | 300 | 45 |
| 2000-06-07 | @ ANA | 56 | L 9-10 | 27-29 | 4 | 22,920 | Russ Ortiz | Kent Bottenfield | Shigetoshi Hasegawa | Alan Embree | | 354 | 310 | 44 |
| 2000-06-09 | vs SEA | 57 | W 9-2 | 28-29 | 4 | 40,930 | Kirk Rueter | John Halama | Kirk Rueter | John Halama | | 363 | 312 | 51 |
| 2000-06-10 | vs SEA | 58 | L 2-5 | 28-30 | 4 | 40,930 | Shawn Estes | Paul Abbott | Paul Abbott | Shawn Estes | | 365 | 317 | 48 |
| 2000-06-11 | vs SEA | 59 | L 2-9 | 28-31 | 4 | 40,930 | Livan Hernandez | Aaron Sele | Aaron Sele | Livan Hernandez | | 367 | 326 | 41 |
| 2000-06-12 | vs CIN | 60 | W 10-3 | 29-31 | 4 | 40,930 | Joe Nathan | Rob Bell | Joe Nathan | Rob Bell | | 377 | 329 | 48 |
| 2000-06-13 | vs CIN | 61 | W 3-2 | 30-31 | 4 | 40,930 | Russ Ortiz | Osvaldo Fernandez | Robb Nen | Danny Graves | | 380 | 331 | 49 |
| 2000-06-14 | vs CIN | 62 | W 6-2 | 31-31 | 4 | 40,930 | Kirk Rueter | Denny Neagle | Kirk Rueter | Denny Neagle | Felix Rodriguez | 386 | 333 | 53 |
| 2000-06-16 | vs HOU | 63 | W 7-4 | 32-31 | 4 | 40,930 | Shawn Estes | Scott Elarton | Shawn Estes | Scott Elarton | Robb Nen | 393 | 337 | 56 |
| 2000-06-17 | vs HOU | 64 | W 6-4 | 33-31 | 4 | 40,930 | Livan Hernandez | Jose Lima | Livan Hernandez | Jose Lima | Robb Nen | 399 | 341 | 58 |
| 2000-06-18 | vs HOU | 65 | L 2-4 | 33-32 | 4 | 40,930 | Joe Nathan | Shane Reynolds | Jay Powell | Robb Nen | Doug Henry | 401 | 345 | 56 |
| 2000-06-20 | @ SLN | 66 | L 2-7 | 33-33 | 4 | 38,939 | Russ Ortiz | Rick Ankiel | Rick Ankiel | Russ Ortiz | | 403 | 352 | 51 |
| 2000-06-21 | @ SLN | 67 | W 4-1 | 34-33 | 4 | 37,341 | Kirk Rueter | Garrett Stephenson | Kirk Rueter | Garrett Stephenson | Robb Nen | 407 | 353 | 54 |
| 2000-06-22 | @ SLN | 68 | L 10-11 | 34-34 | 4 | 36,192 | Shawn Estes | Pat Hentgen | Dave Veres | Mark Gardner | | 417 | 364 | 53 |
| 2000-06-23 | @ HOU | 69 | W 10-3 | 35-34 | 4 | 40,367 | Livan Hernandez | Jose Lima | Livan Hernandez | Jose Lima | | 427 | 367 | 60 |
| 2000-06-24 | @ HOU | 70 | W 13-4 | 36-34 | 4 | 42,708 | Joe Nathan | Shane Reynolds | Joe Nathan | Shane Reynolds | | 440 | 371 | 69 |
| 2000-06-25 | @ HOU | 71 | W 4-2 | 37-34 | 3 | 42,201 | Russ Ortiz | Chris Holt | Russ Ortiz | Chris Holt | Robb Nen | 444 | 373 | 71 |
| 2000-06-26 | @ COL | 72 | L 6-15 | 37-35 | 3 | 40,197 | Kirk Rueter | Rolando Arrojo | Rolando Arrojo | Mark Gardner | | 450 | 388 | 62 |
| 2000-06-27 | @ COL | 73 | W 12-7 | 38-35 | 3 | 41,573 | Shawn Estes | Kevin Jarvis | Shawn Estes | Kevin Jarvis | | 462 | 395 | 67 |
| 2000-06-28 | @ COL | 74 | L 13-17 | 38-36 | 4 | 43,405 | Livan Hernandez | Brian Bohanon | Mike DeJean | John Johnstone | | 475 | 412 | 63 |
| 2000-06-29 | @ COL | 75 | L 4-11 | 38-37 | 4 | 43,946 | Joe Nathan | Masato Yoshii | Masato Yoshii | Joe Nathan | | 479 | 423 | 56 |
| 2000-06-30 | vs LAN | 76 | L 2-9 | 38-38 | 4 | 40,930 | Russ Ortiz | Kevin Brown | Kevin Brown | Russ Ortiz | | 481 | 432 | 49 |
| 2000-07-01 | vs LAN | 77 | W 4-1 | 39-38 | 4 | 40,930 | Kirk Rueter | Carlos Perez | Kirk Rueter | Carlos Perez | Robb Nen | 485 | 433 | 52 |
| 2000-07-02 | vs LAN | 78 | W 6-5 | 40-38 | 3 | 40,930 | Shawn Estes | Eric Gagne | Robb Nen | Mike Fetters | | 491 | 438 | 53 |
| 2000-07-04 | vs COL | 79 | W 4-1 | 42-38 | 3 | 40,930 | Livan Hernandez | Masato Yoshii | Livan Hernandez | Masato Yoshii | Robb Nen | 495 | 439 | 56 |
| 2000-07-04 | vs COL | 80 | W 3-0 | 42-38 | 3 | 40,930 | Mark Gardner | Scott Karl | Mark Gardner | Scott Karl | Robb Nen | 498 | 439 | 59 |
| 2000-07-05 | vs COL | 81 | W 4-2 | 43-38 | 3 | 40,930 | Joe Nathan | Pedro Astacio | Joe Nathan | Stan Belinda | Felix Rodriguez | 502 | 441 | 61 |
| 2000-07-06 | vs COL | 82 | W 6-5 | 44-38 | 3 | 40,930 | Russ Ortiz | Rolando Arrojo | Robb Nen | Mike Myers | | 508 | 446 | 62 |
| 2000-07-07 | @ SLN | 83 | W 4-2 | 45-38 | 3 | 46,738 | Kirk Rueter | Darryl Kile | Alan Embree | Matt Morris | Robb Nen | 512 | 448 | 64 |
| 2000-07-08 | @ SLN | 84 | W 7-6 | 46-38 | 2 | 47,227 | Shawn Estes | Garrett Stephenson | Shawn Estes | Garrett Stephenson | Robb Nen | 519 | 454 | 65 |
| 2000-07-09 | @ SLN | 85 | L 7-8 | 46-39 | 2 | 44,202 | Livan Hernandez | Pat Hentgen | Pat Hentgen | Livan Hernandez | Dave Veres | 526 | 462 | 64 |
| 2000-07-13 | vs OAK | 86 | W 4-2 | 47-39 | 2 | 40,930 | Joe Nathan | Mark Mulder | Russ Ortiz | Mark Mulder | Robb Nen | 530 | 464 | 66 |
| 2000-07-14 | vs OAK | 87 | W 4-2 | 48-39 | 2 | 40,930 | Mark Gardner | Kevin Appier | Mark Gardner | Kevin Appier | Robb Nen | 534 | 466 | 68 |
| 2000-07-15 | vs OAK | 88 | L 2-6 | 48-40 | 2 | 40,930 | Kirk Rueter | Gil Heredia | Gil Heredia | Kirk Rueter | | 536 | 472 | 64 |
| 2000-07-16 | vs TEX | 89 | W 6-4 | 49-40 | 2 | 40,930 | Shawn Estes | Esteban Loaiza | Shawn Estes | Esteban Loaiza | Robb Nen | 542 | 476 | 66 |
| 2000-07-17 | vs TEX | 90 | W 10-8 | 50-40 | 2 | 40,930 | Livan Hernandez | Ryan Glynn | Livan Hernandez | Doug Davis | Robb Nen | 552 | 484 | 68 |
| 2000-07-18 | vs TEX | 91 | W 5-3 | 51-40 | 2 | 40,930 | Russ Ortiz | Rick Helling | Aaron Fultz | John Wetteland | | 557 | 487 | 70 |
| 2000-07-19 | vs SDN | 92 | L 3-4 | 51-41 | 2 | 40,930 | Mark Gardner | Brian Meadows | Donne Wall | Alan Embree | | 560 | 491 | 69 |
| 2000-07-20 | vs SDN | 93 | W 7-3 | 52-41 | 2 | 40,930 | Kirk Rueter | Woody Williams | Kirk Rueter | Woody Williams | Aaron Fultz | 567 | 494 | 73 |
| 2000-07-21 | @ LAN | 94 | L 5-6 | 52-42 | 2 | 53,563 | Shawn Estes | Carlos Perez | Matt Herges | Felix Rodriguez | Jeff Shaw | 572 | 500 | 72 |
| 2000-07-22 | @ LAN | 95 | W 5-2 | 53-42 | 2 | 45,705 | Livan Hernandez | Eric Gagne | Livan Hernandez | Eric Gagne | Robb Nen | 577 | 502 | 75 |
| 2000-07-23 | @ LAN | 96 | L 0-5 | 53-43 | 2 | 47,969 | Russ Ortiz | Darren Dreifort | Darren Dreifort | Russ Ortiz | | 577 | 507 | 70 |
| 2000-07-24 | @ SDN | 97 | W 3-0 | 54-43 | 2 | 22,405 | Mark Gardner | Brian Meadows | Mark Gardner | Brian Meadows | Robb Nen | 580 | 507 | 73 |
| 2000-07-25 | @ SDN | 98 | L 2-3 | 54-44 | 2 | 25,039 | Kirk Rueter | Woody Williams | Woody Williams | Kirk Rueter | Trevor Hoffman | 582 | 510 | 72 |
| 2000-07-26 | @ SDN | 99 | W 3-1 | 55-44 | 1 | 27,172 | Shawn Estes | Adam Eaton | Shawn Estes | Adam Eaton | Robb Nen | 585 | 511 | 74 |
| 2000-07-28 | @ CHN | 100 | W 2-0 | 56-44 | 2 | 39,817 | Livan Hernandez | Ruben Quevedo | Livan Hernandez | Tim Worrell | Robb Nen | 587 | 511 | 76 |
| 2000-07-29 | @ CHN | 101 | L 1-8 | 56-45 | 2 | 40,320 | Russ Ortiz | Kerry Wood | Kerry Wood | Russ Ortiz | Kyle Farnsworth | 588 | 519 | 69 |
| 2000-07-30 | @ CHN | 102 | L 1-3 | 56-46 | 2 | 38,453 | Kirk Rueter | Jon Lieber | Jon Lieber | Kirk Rueter | | 589 | 522 | 67 |
| 2000-07-31 | @ MIL | 103 | W 4-3 | 57-46 | 1 | 20,530 | Mark Gardner | Jimmy Haynes | Felix Rodriguez | David Weathers | Robb Nen | 593 | 525 | 68 |
| 2000-08-01 | @ MIL | 104 | W 13-8 | 58-46 | 1 | 15,722 | Shawn Estes | John Snyder | Doug Henry | Ray King | | 606 | 533 | 73 |
| 2000-08-02 | @ MIL | 105 | L 4-6 | 58-47 | 1 | 25,753 | Livan Hernandez | Jamey Wright | Juan Acevedo | Livan Hernandez | Curt Leskanic | 610 | 539 | 71 |
| 2000-08-03 | vs PIT | 106 | W 10-2 | 59-47 | 1 | 40,930 | Russ Ortiz | Francisco Cordova | Russ Ortiz | Francisco Cordova | | 620 | 541 | 79 |
| 2000-08-04 | vs PIT | 107 | W 5-3 | 60-47 | 1 | 40,930 | Kirk Rueter | Kris Benson | Doug Henry | Kris Benson | Robb Nen | 625 | 544 | 81 |
| 2000-08-05 | vs PIT | 108 | L 2-7 | 60-48 | 1 | 40,930 | Mark Gardner | Dan Serafini | Dan Serafini | Mark Gardner | | 627 | 551 | 76 |
| 2000-08-06 | vs PIT | 109 | W 7-1 | 61-48 | 1 | 40,930 | Shawn Estes | Bronson Arroyo | Shawn Estes | Bronson Arroyo | | 634 | 552 | 82 |
| 2000-08-07 | vs MIL | 110 | W 8-1 | 62-48 | 1 | 40,930 | Livan Hernandez | John Snyder | Livan Hernandez | John Snyder | | 642 | 553 | 89 |
| 2000-08-08 | vs MIL | 111 | W 1-0 | 63-48 | 1 | 40,930 | Russ Ortiz | Jamey Wright | Russ Ortiz | Jamey Wright | Robb Nen | 643 | 553 | 90 |
| 2000-08-09 | vs MIL | 112 | W 9-3 | 64-48 | 1 | 40,930 | Kirk Rueter | Paul Rigdon | Kirk Rueter | Paul Rigdon | | 652 | 556 | 96 |
| 2000-08-11 | @ NYN | 113 | L 1-4 | 64-49 | 1 | 33,944 | Mark Gardner | Glendon Rusch | Glendon Rusch | Mark Gardner | Armando Benitez | 653 | 560 | 93 |
| 2000-08-12 | @ NYN | 114 | L 2-3 | 64-50 | 1 | 50,064 | Shawn Estes | Mike Hampton | Mike Hampton | Felix Rodriguez | Armando Benitez | 655 | 563 | 92 |
| 2000-08-13 | @ NYN | 115 | L 0-2 | 64-51 | 1 | 39,841 | Livan Hernandez | Al Leiter | Al Leiter | Livan Hernandez | John Franco | 655 | 565 | 90 |
| 2000-08-14 | @ NYN | 116 | W 11-1 | 65-51 | 1 | 35,296 | Russ Ortiz | Rick Reed | Russ Ortiz | Rick Reed | | 666 | 566 | 100 |
| 2000-08-15 | @ MON | 117 | W 9-7 | 66-51 | 1 | 7,165 | Kirk Rueter | Mike Johnson | Miguel Del Toro | Felipe Lira | Robb Nen | 675 | 573 | 102 |
| 2000-08-16 | @ MON | 118 | W 4-1 | 67-51 | 1 | 7,910 | Mark Gardner | Dustin Hermanson | Mark Gardner | Dustin Hermanson | Robb Nen | 679 | 574 | 105 |
| 2000-08-17 | @ MON | 119 | W 5-4 | 68-51 | 1 | 9,198 | Shawn Estes | Trey Moore | Shawn Estes | Trey Moore | Felix Rodriguez | 684 | 578 | 106 |
| 2000-08-18 | vs ATL | 120 | W 2-0 | 69-51 | 1 | 40,930 | Livan Hernandez | Greg Maddux | Livan Hernandez | Greg Maddux | | 686 | 578 | 108 |
| 2000-08-19 | vs ATL | 121 | W 12-3 | 70-51 | 1 | 40,930 | Russ Ortiz | Andy Ashby | Russ Ortiz | Andy Ashby | | 698 | 581 | 117 |
| 2000-08-20 | vs ATL | 122 | L 5-8 | 70-52 | 1 | 40,930 | Kirk Rueter | Tom Glavine | Tom Glavine | Kirk Rueter | | 703 | 589 | 114 |
| 2000-08-21 | vs FLO | 123 | W 6-0 | 71-52 | 1 | 40,930 | Mark Gardner | Ryan Dempster | Mark Gardner | Ryan Dempster | | 709 | 589 | 120 |
| 2000-08-22 | vs FLO | 124 | L 5-7 | 71-53 | 1 | 40,930 | Shawn Estes | A.J. Burnett | A.J. Burnett | Shawn Estes | Antonio Alfonseca | 714 | 596 | 118 |
| 2000-08-23 | vs FLO | 125 | W 5-0 | 72-53 | 1 | 40,930 | Livan Hernandez | Chuck Smith | Livan Hernandez | Chuck Smith | | 719 | 596 | 123 |
| 2000-08-25 | @ PHI | 126 | W 16-3 | 73-53 | 1 | 18,384 | Russ Ortiz | Kent Bottenfield | Russ Ortiz | Kent Bottenfield | | 735 | 599 | 136 |
| 2000-08-26 | @ PHI | 127 | L 2-5 | 73-54 | 1 | 19,636 | Kirk Rueter | Randy Wolf | Randy Wolf | Kirk Rueter | Jeff Brantley | 737 | 604 | 133 |
| 2000-08-27 | @ PHI | 128 | L 1-2 | 73-55 | 1 | 18,717 | Mark Gardner | Bruce Chen | Ed Vosberg | Aaron Fultz | | 738 | 606 | 132 |
| 2000-08-28 | @ PIT | 129 | W 5-4 | 74-55 | 1 | 15,125 | Shawn Estes | Todd Ritchie | Alan Embree | Scott Sauerbeck | Robb Nen | 743 | 610 | 133 |
| 2000-08-29 | @ PIT | 130 | L 0-8 | 74-56 | 1 | 14,306 | Livan Hernandez | Kris Benson | Kris Benson | Livan Hernandez | | 743 | 618 | 125 |
| 2000-08-30 | @ PIT | 131 | W 2-0 | 75-56 | 1 | 16,576 | Russ Ortiz | Jimmy Anderson | Russ Ortiz | Jimmy Anderson | Robb Nen | 745 | 618 | 127 |
| 2000-08-31 | @ PIT | 132 | W 10-2 | 76-56 | 1 | 13,781 | Kirk Rueter | Jose Silva | Kirk Rueter | Jose Silva | | 755 | 620 | 135 |
| 2000-09-01 | vs CHN | 133 | W 7-2 | 77-56 | 1 | 40,930 | Mark Gardner | Kerry Wood | Mark Gardner | Kerry Wood | | 762 | 622 | 140 |
| 2000-09-02 | vs CHN | 134 | W 13-2 | 78-56 | 1 | 40,930 | Shawn Estes | Ruben Quevedo | Shawn Estes | Ruben Quevedo | | 775 | 624 | 151 |
| 2000-09-03 | vs CHN | 135 | W 5-2 | 79-56 | 1 | 40,930 | Livan Hernandez | Daniel Garibay | Livan Hernandez | Daniel Garibay | Robb Nen | 780 | 626 | 154 |
| 2000-09-04 | vs PHI | 136 | W 3-0 | 80-56 | 1 | 40,930 | Russ Ortiz | Omar Daal | Russ Ortiz | Omar Daal | Robb Nen | 783 | 626 | 157 |
| 2000-09-05 | vs PHI | 137 | W 8-5 | 81-56 | 1 | 40,930 | Kirk Rueter | Kent Bottenfield | John Johnstone | Ed Vosberg | Robb Nen | 791 | 631 | 160 |
| 2000-09-06 | vs PHI | 138 | W 5-4 | 82-56 | 1 | 40,930 | Mark Gardner | Randy Wolf | Aaron Fultz | Vicente Padilla | Alan Embree | 796 | 635 | 161 |
| 2000-09-07 | vs SDN | 139 | W 13-0 | 83-56 | 1 | 40,930 | Shawn Estes | Matt Clement | Shawn Estes | Matt Clement | | 809 | 635 | 174 |
| 2000-09-08 | vs SDN | 140 | L 7-10 | 83-57 | 1 | 40,930 | Livan Hernandez | Will Cunnane | Carlos Almanzar | Alan Embree | Trevor Hoffman | 816 | 645 | 171 |
| 2000-09-09 | vs SDN | 141 | L 3-7 | 83-58 | 1 | 40,930 | Russ Ortiz | Brian Tollberg | Brian Tollberg | Russ Ortiz | | 819 | 652 | 167 |
| 2000-09-10 | vs SDN | 142 | W 10-2 | 84-58 | 1 | 40,930 | Kirk Rueter | Jay Witasick | Kirk Rueter | Jay Witasick | | 829 | 654 | 175 |
| 2000-09-11 | @ HOU | 143 | W 8-7 | 85-58 | 1 | 35,130 | Joe Nathan | Jose Lima | Robb Nen | Marc Valdes | | 837 | 661 | 176 |
| 2000-09-12 | @ HOU | 144 | W 9-5 | 86-58 | 1 | 30,500 | Shawn Estes | Scott Elarton | Shawn Estes | Scott Elarton | | 846 | 666 | 180 |
| 2000-09-13 | @ HOU | 145 | W 3-2 | 87-58 | 1 | 30,553 | Livan Hernandez | Wade Miller | Livan Hernandez | Wade Miller | Robb Nen | 849 | 668 | 181 |
| 2000-09-15 | @ SDN | 146 | L 4-5 | 87-59 | 1 | 26,600 | Russ Ortiz | Brian Tollberg | Tom Davey | Doug Henry | Trevor Hoffman | 853 | 673 | 180 |
| 2000-09-16 | @ SDN | 147 | W 4-3 | 88-59 | 1 | 55,695 | Kirk Rueter | Jay Witasick | Alan Embree | Carlos Almanzar | Robb Nen | 857 | 676 | 181 |
| 2000-09-17 | @ SDN | 148 | W 5-1 | 89-59 | 1 | 28,673 | Mark Gardner | Woody Williams | Mark Gardner | Woody Williams | | 862 | 677 | 185 |
| 2000-09-18 | vs CIN | 149 | L 1-7 | 89-60 | 1 | 40,930 | Shawn Estes | Osvaldo Fernandez | Osvaldo Fernandez | Shawn Estes | | 863 | 684 | 179 |
| 2000-09-19 | vs CIN | 150 | W 7-3 | 90-60 | 1 | 40,930 | Livan Hernandez | Rob Bell | Livan Hernandez | Rob Bell | | 870 | 687 | 183 |
| 2000-09-20 | vs CIN | 151 | W 4-2 | 91-60 | 1 | 40,930 | Russ Ortiz | Steve Parris | Russ Ortiz | Steve Parris | Robb Nen | 874 | 689 | 185 |
| 2000-09-21 | vs ARI | 152 | W 8-7 | 92-60 | 1 | 40,930 | Kirk Rueter | Todd Stottlemyre | Doug Henry | Mike Morgan | Robb Nen | 882 | 696 | 186 |
| 2000-09-22 | vs ARI | 153 | L 1-7 | 92-61 | 1 | 40,930 | Mark Gardner | Curt Schilling | Curt Schilling | Mark Gardner | | 883 | 703 | 180 |
| 2000-09-23 | vs ARI | 154 | L 5-7 | 93-62 | 1 | 40,930 | Shawn Estes | Geraldo Guzman | Geraldo Guzman | Shawn Estes | Matt Mantei | 888 | 710 | 178 |
| 2000-09-23 | vs ARI | 155 | W 9-5 | 93-62 | 1 | 40,930 | Miguel Del Toro | Armando Reynoso | Miguel Del Toro | Armando Reynoso | | 897 | 715 | 182 |
| 2000-09-24 | vs ARI | 156 | L 3-8 | 93-63 | 1 | 40,930 | Livan Hernandez | Brian Anderson | Brian Anderson | Livan Hernandez | | 900 | 723 | 177 |
| 2000-09-26 | @ LAN | 157 | L 0-9 | 93-64 | 1 | 43,909 | Russ Ortiz | Darren Dreifort | Darren Dreifort | Russ Ortiz | | 900 | 732 | 168 |
| 2000-09-27 | @ LAN | 158 | W 4-0 | 94-64 | 1 | 44,232 | Kirk Rueter | Luke Prokopec | Kirk Rueter | Luke Prokopec | | 904 | 732 | 172 |
| 2000-09-28 | @ LAN | 159 | W 5-3 | 95-64 | 1 | 44,513 | Shawn Estes | Kevin Brown | Aaron Fultz | Terry Adams | Robb Nen | 909 | 735 | 174 |
| 2000-09-29 | @ ARI | 160 | W 4-3 | 96-64 | 1 | 38,435 | Livan Hernandez | Brian Anderson | Livan Hernandez | Brian Anderson | Robb Nen | 913 | 738 | 175 |
| 2000-09-30 | @ ARI | 161 | L 1-5 | 96-65 | 1 | 42,794 | Mark Gardner | Geraldo Guzman | Geraldo Guzman | Alan Embree | | 914 | 743 | 171 |
| 2000-10-01 | @ ARI | 162 | W 11-4 | 97-65 | 1 | 41,483 | Russ Ortiz | Randy Johnson | Russ Ortiz | Randy Johnson | | 925 | 747 | 178 |