| 2000-04-03 | @ NYN | 1 | L 1-2 | 0-1 | 4 | 52,308 | Sterling Hitchcock | Al Leiter | Al Leiter | Donne Wall | Armando Benitez | 1 | 2 | -1 |
| 2000-04-05 | @ NYN | 2 | W 4-0 | 1-1 | 4 | 17,585 | Woody Williams | Robert Joseph Jones | Woody Williams | Robert Joseph Jones | | 5 | 2 | 3 |
| 2000-04-06 | @ NYN | 3 | W 8-5 | 2-1 | 2 | 17,482 | Matt Clement | Mike Hampton | Matt Clement | Mike Hampton | | 13 | 7 | 6 |
| 2000-04-07 | @ MON | 4 | W 10-5 | 3-1 | 2 | 12,260 | Brian Meadows | Jeremy Powell | Brian Meadows | Jeremy Powell | | 23 | 12 | 11 |
| 2000-04-08 | @ MON | 5 | L 9-10 | 3-2 | 2 | 13,528 | Sterling Hitchcock | Dustin Hermanson | Anthony Telford | Donne Wall | Ugueth Urbina | 32 | 22 | 10 |
| 2000-04-09 | @ MON | 6 | L 1-2 | 3-3 | 3 | 9,782 | Brian Boehringer | Hideki Irabu | Hideki Irabu | Brian Boehringer | Ugueth Urbina | 33 | 24 | 9 |
| 2000-04-10 | vs ARI | 7 | L 4-8 | 3-4 | 4 | 60,021 | Woody Williams | Todd Stottlemyre | Todd Stottlemyre | Woody Williams | Mike Morgan | 37 | 32 | 5 |
| 2000-04-11 | vs ARI | 8 | W 3-2 | 4-4 | 3 | 19,035 | Matt Clement | Omar Daal | Matt Whisenant | Russ Springer | | 40 | 34 | 6 |
| 2000-04-12 | vs ARI | 9 | W 4-2 | 5-4 | 3 | 15,801 | Brian Meadows | Armando Reynoso | Brian Meadows | Armando Reynoso | Trevor Hoffman | 44 | 36 | 8 |
| 2000-04-13 | vs ARI | 10 | L 4-5 | 5-5 | 4 | 28,131 | Sterling Hitchcock | Brian Anderson | Brian Anderson | Sterling Hitchcock | Mike Morgan | 48 | 41 | 7 |
| 2000-04-14 | vs HOU | 11 | L 4-10 | 5-6 | 4 | 30,951 | Brian Boehringer | Shane Reynolds | Shane Reynolds | Brian Boehringer | | 52 | 51 | 1 |
| 2000-04-15 | vs HOU | 12 | W 5-3 | 6-6 | 4 | 45,242 | Woody Williams | Jose Lima | Woody Williams | Jose Lima | Trevor Hoffman | 57 | 54 | 3 |
| 2000-04-16 | vs HOU | 13 | W 13-3 | 7-6 | 4 | 46,352 | Matt Clement | Chris Holt | Matt Clement | Chris Holt | | 70 | 57 | 13 |
| 2000-04-18 | @ SLN | 14 | L 4-5 | 7-7 | 4 | 32,062 | Brian Meadows | Andy Benes | Andy Benes | Brian Meadows | Dave Veres | 74 | 62 | 12 |
| 2000-04-19 | @ SLN | 15 | L 3-4 | 7-8 | 4 | 27,997 | Sterling Hitchcock | Darryl Kile | Darryl Kile | Sterling Hitchcock | Dave Veres | 77 | 66 | 11 |
| 2000-04-20 | @ SLN | 16 | L 1-14 | 7-9 | 4 | 32,510 | Brian Boehringer | Rick Ankiel | Rick Ankiel | Brian Boehringer | | 78 | 80 | -2 |
| 2000-04-21 | @ HOU | 17 | W 7-2 | 8-9 | 4 | 42,092 | Woody Williams | Jose Lima | Woody Williams | Jose Lima | | 85 | 82 | 3 |
| 2000-04-22 | @ HOU | 18 | W 8-6 | 9-9 | 4 | 42,121 | Matt Clement | Chris Holt | Will Cunnane | Yorkis Perez | Trevor Hoffman | 93 | 88 | 5 |
| 2000-04-23 | @ HOU | 19 | W 11-10 | 10-9 | 3 | 38,695 | Brian Meadows | Scott Elarton | Matt Whisenant | Billy Wagner | Trevor Hoffman | 104 | 98 | 6 |
| 2000-04-25 | @ PIT | 20 | L 3-4 | 10-10 | 3 | 12,295 | Sterling Hitchcock | Todd Ritchie | Scott Sauerbeck | Carlos Almanzar | | 107 | 102 | 5 |
| 2000-04-26 | @ PIT | 21 | L 8-9 | 10-11 | 3 | 13,765 | Woody Williams | Jimmy Anderson | Mike Williams | Matt Whisenant | | 115 | 111 | 4 |
| 2000-04-27 | @ PIT | 22 | W 12-4 | 11-11 | 3 | 15,459 | Matt Clement | Jose Parra | Matt Clement | Jose Parra | | 127 | 115 | 12 |
| 2000-04-28 | vs ATL | 23 | L 2-7 | 11-12 | 4 | 33,995 | Brian Meadows | Greg Maddux | Greg Maddux | Brian Meadows | Mike Remlinger | 129 | 122 | 7 |
| 2000-04-29 | vs ATL | 24 | L 4-7 | 11-13 | 4 | 49,428 | Rodrigo Lopez | John Burkett | Bruce Chen | Vicente Palacios | John Rocker | 133 | 129 | 4 |
| 2000-04-30 | vs ATL | 25 | L 4-7 | 11-14 | 4 | 44,845 | Sterling Hitchcock | Tom Glavine | Tom Glavine | Sterling Hitchcock | | 137 | 136 | 1 |
| 2000-05-01 | vs FLO | 26 | L 2-5 | 11-15 | 5 | 32,083 | Woody Williams | Ryan Dempster | Ryan Dempster | Woody Williams | Antonio Alfonseca | 139 | 141 | -2 |
| 2000-05-02 | vs FLO | 27 | W 8-3 | 12-15 | 5 | 24,139 | Matt Clement | Vladimir Nunez | Matt Clement | Vladimir Nunez | | 147 | 144 | 3 |
| 2000-05-03 | vs FLO | 28 | W 3-1 | 13-15 | 5 | 14,586 | Brian Meadows | Brad Penny | Brian Meadows | Brad Penny | Trevor Hoffman | 150 | 145 | 5 |
| 2000-05-05 | @ ARI | 29 | L 3-5 | 13-16 | 5 | 42,297 | Sterling Hitchcock | Randy Johnson | Randy Johnson | Sterling Hitchcock | | 153 | 150 | 3 |
| 2000-05-06 | @ ARI | 30 | L 5-10 | 13-17 | 5 | 36,827 | Rodrigo Lopez | Brian Anderson | Brian Anderson | Rodrigo Lopez | | 158 | 160 | -2 |
| 2000-05-07 | @ ARI | 31 | L 1-8 | 13-18 | 5 | 38,060 | Matt Clement | Todd Stottlemyre | Todd Stottlemyre | Matt Clement | | 159 | 168 | -9 |
| 2000-05-09 | @ CIN | 32 | L 0-2 | 13-19 | 5 | 22,435 | Brian Meadows | Steve Parris | Steve Parris | Brian Meadows | Danny Graves | 159 | 170 | -11 |
| 2000-05-10 | @ CIN | 33 | L 1-5 | 13-20 | 5 | 27,797 | Sterling Hitchcock | Ron Villone | Ron Villone | Sterling Hitchcock | Scott Williamson | 160 | 175 | -15 |
| 2000-05-11 | @ CIN | 34 | L 9-11 | 13-21 | 5 | 24,825 | Rodrigo Lopez | Rob Bell | Danny Graves | Matt Whisenant | | 169 | 186 | -17 |
| 2000-05-12 | vs ARI | 35 | L 4-6 | 13-22 | 5 | 24,391 | Matt Clement | Brian Anderson | Brian Anderson | Matt Clement | Byung-Hyun Kim | 173 | 192 | -19 |
| 2000-05-13 | vs ARI | 36 | L 2-6 | 13-23 | 5 | 44,044 | Stan Spencer | Todd Stottlemyre | Todd Stottlemyre | Stan Spencer | Mike Morgan | 175 | 198 | -23 |
| 2000-05-14 | vs ARI | 37 | W 3-1 | 14-23 | 5 | 31,555 | Brian Meadows | Omar Daal | Brian Meadows | Omar Daal | Trevor Hoffman | 178 | 199 | -21 |
| 2000-05-16 | @ FLO | 38 | W 7-3 | 15-23 | 5 | 7,101 | Sterling Hitchcock | Jesus Sanchez | Sterling Hitchcock | Jesus Sanchez | | 185 | 202 | -17 |
| 2000-05-17 | @ FLO | 39 | L 2-4 | 15-24 | 5 | 6,955 | Matt Clement | Ryan Dempster | Ryan Dempster | Matt Clement | Antonio Alfonseca | 187 | 206 | -19 |
| 2000-05-18 | @ FLO | 40 | W 6-2 | 16-24 | 5 | 7,832 | Stan Spencer | Alex Fernandez | Stan Spencer | Alex Fernandez | | 193 | 208 | -15 |
| 2000-05-19 | @ ATL | 41 | W 11-7 | 17-24 | 5 | 39,423 | Brian Meadows | Terry Mulholland | Matt Whiteside | Terry Mulholland | Trevor Hoffman | 204 | 215 | -11 |
| 2000-05-20 | @ ATL | 42 | L 6-10 | 17-25 | 5 | 49,653 | Will Cunnane | John Burkett | John Burkett | Will Cunnane | | 210 | 225 | -15 |
| 2000-05-21 | @ ATL | 43 | L 6-12 | 17-26 | 5 | 40,533 | Sterling Hitchcock | Tom Glavine | Tom Glavine | Sterling Hitchcock | | 216 | 237 | -21 |
| 2000-05-22 | vs NYN | 44 | W 1-0 | 18-26 | 5 | 17,966 | Matt Clement | Glendon Rusch | Matt Clement | John Franco | Trevor Hoffman | 217 | 237 | -20 |
| 2000-05-23 | vs NYN | 45 | L 3-5 | 18-27 | 5 | 25,783 | Stan Spencer | Al Leiter | Turk Wendell | Trevor Hoffman | Armando Benitez | 220 | 242 | -22 |
| 2000-05-24 | vs NYN | 46 | W 5-4 | 19-27 | 5 | 19,405 | Brian Meadows | Robert Joseph Jones | Donne Wall | Pat Mahomes | Trevor Hoffman | 225 | 246 | -21 |
| 2000-05-26 | vs MON | 47 | W 6-2 | 20-27 | 5 | 19,517 | Sterling Hitchcock | Hideki Irabu | Matt Whiteside | Hideki Irabu | | 231 | 248 | -17 |
| 2000-05-27 | vs MON | 48 | W 4-2 | 21-27 | 5 | 40,110 | Matt Clement | Javier Vazquez | Donne Wall | Steve Kline | Trevor Hoffman | 235 | 250 | -15 |
| 2000-05-28 | vs MON | 49 | W 4-3 | 22-27 | 5 | 26,411 | Stan Spencer | Carl Pavano | Kevin Walker | Carl Pavano | Trevor Hoffman | 239 | 253 | -14 |
| 2000-05-29 | vs MIL | 50 | L 3-8 | 22-28 | 5 | 16,863 | Brian Meadows | Jimmy Haynes | Jimmy Haynes | Brian Meadows | | 242 | 261 | -19 |
| 2000-05-30 | vs MIL | 51 | W 6-3 | 23-28 | 5 | 15,379 | Adam Eaton | Jeff D'Amico | Adam Eaton | Jeff D'Amico | Trevor Hoffman | 248 | 264 | -16 |
| 2000-05-31 | vs MIL | 52 | W 9-5 | 24-28 | 5 | 14,784 | Rodrigo Lopez | John Snyder | Carlos Almanzar | David Weathers | | 257 | 269 | -12 |
| 2000-06-02 | @ SEA | 53 | L 4-7 | 24-29 | 5 | 33,995 | Matt Clement | Jamie Moyer | Jamie Moyer | Matt Clement | Kazuhiro Sasaki | 261 | 276 | -15 |
| 2000-06-03 | @ SEA | 54 | W 7-4 | 25-29 | 5 | 44,183 | Stan Spencer | John Halama | Stan Spencer | John Halama | Trevor Hoffman | 268 | 280 | -12 |
| 2000-06-04 | @ SEA | 55 | L 4-6 | 25-30 | 5 | 42,018 | Brian Meadows | Paul Abbott | Paul Abbott | Brian Meadows | | 272 | 286 | -14 |
| 2000-06-05 | @ OAK | 56 | L 2-3 | 25-31 | 5 | 10,187 | Adam Eaton | Kevin Appier | Jason Isringhausen | Carlos Almanzar | | 274 | 289 | -15 |
| 2000-06-06 | @ OAK | 57 | L 4-5 | 25-32 | 5 | 14,251 | Rodrigo Lopez | Gil Heredia | Gil Heredia | Rodrigo Lopez | Jason Isringhausen | 278 | 294 | -16 |
| 2000-06-07 | @ OAK | 58 | L 4-10 | 25-33 | 5 | 23,408 | Matt Clement | Mark Mulder | Scott Service | Matt Clement | Doug Jones | 282 | 304 | -22 |
| 2000-06-09 | vs HOU | 59 | L 6-7 | 25-34 | 5 | 24,522 | Stan Spencer | Octavio Dotel | Billy Wagner | Trevor Hoffman | | 288 | 311 | -23 |
| 2000-06-10 | vs HOU | 60 | W 13-3 | 26-34 | 5 | 49,860 | Brian Meadows | Scott Elarton | Brian Meadows | Scott Elarton | | 301 | 314 | -13 |
| 2000-06-11 | vs HOU | 61 | W 4-1 | 27-34 | 5 | 27,120 | Adam Eaton | Jose Lima | Kevin Walker | Jose Lima | Trevor Hoffman | 305 | 315 | -10 |
| 2000-06-12 | vs SLN | 62 | L 3-7 | 27-35 | 5 | 23,359 | Matt Clement | Andy Benes | Andy Benes | Matt Clement | | 308 | 322 | -14 |
| 2000-06-13 | vs SLN | 63 | L 3-8 | 27-36 | 5 | 29,055 | Rodrigo Lopez | Darryl Kile | Darryl Kile | Rodrigo Lopez | Dave Veres | 311 | 330 | -19 |
| 2000-06-14 | vs SLN | 64 | L 1-3 | 27-37 | 5 | 30,952 | Stan Spencer | Garrett Stephenson | Garrett Stephenson | Stan Spencer | Matt Morris | 312 | 333 | -21 |
| 2000-06-16 | vs CIN | 65 | W 8-5 | 28-37 | 5 | 60,760 | Brian Meadows | Steve Parris | Carlos Reyes | Steve Parris | Trevor Hoffman | 320 | 338 | -18 |
| 2000-06-17 | vs CIN | 66 | W 3-1 | 29-37 | 5 | 40,730 | Adam Eaton | Ron Villone | Kevin Walker | Ron Villone | Trevor Hoffman | 323 | 339 | -16 |
| 2000-06-18 | vs CIN | 67 | W 8-7 | 30-37 | 5 | 39,823 | Matt Clement | Rob Bell | Matt Clement | Rob Bell | Trevor Hoffman | 331 | 346 | -15 |
| 2000-06-19 | @ ARI | 68 | L 2-3 | 30-38 | 5 | 37,336 | Stan Spencer | Randy Johnson | Vicente Padilla | Brandon Kolb | | 333 | 349 | -16 |
| 2000-06-20 | @ ARI | 69 | W 3-1 | 31-38 | 5 | 30,011 | Brian Tollberg | Todd Stottlemyre | Brian Tollberg | Todd Stottlemyre | Trevor Hoffman | 336 | 350 | -14 |
| 2000-06-21 | @ ARI | 70 | L 8-11 | 31-39 | 5 | 33,003 | Brian Meadows | Omar Daal | Mike Morgan | Carlos Reyes | | 344 | 361 | -17 |
| 2000-06-23 | @ CIN | 71 | W 10-7 | 32-39 | 5 | 31,746 | Adam Eaton | Rob Bell | Trevor Hoffman | Scott Williamson | Carlos Reyes | 354 | 368 | -14 |
| 2000-06-24 | @ CIN | 72 | L 5-11 | 32-40 | 5 | 43,033 | Matt Clement | Ron Villone | Ron Villone | Matt Clement | Elmer Dessens | 359 | 379 | -20 |
| 2000-06-25 | @ CIN | 73 | W 5-4 | 33-40 | 5 | 33,247 | Brian Tollberg | Osvaldo Fernandez | Brian Tollberg | Osvaldo Fernandez | Trevor Hoffman | 364 | 383 | -19 |
| 2000-06-26 | @ LAN | 74 | W 9-5 | 34-40 | 5 | 26,417 | Brian Meadows | Orel Hershiser | Brian Meadows | Orel Hershiser | | 373 | 388 | -15 |
| 2000-06-27 | @ LAN | 75 | L 4-5 | 34-41 | 5 | 41,897 | Will Cunnane | Eric Gagne | Mike Fetters | Matt Whiteside | | 377 | 393 | -16 |
| 2000-06-28 | @ LAN | 76 | L 4-5 | 34-42 | 5 | 32,351 | Adam Eaton | Chan Ho Park | Terry Adams | Steve Montgomery | | 381 | 398 | -17 |
| 2000-06-29 | @ LAN | 77 | W 5-4 | 35-42 | 5 | 50,171 | Matt Clement | Darren Dreifort | Matt Clement | Darren Dreifort | Trevor Hoffman | 386 | 402 | -16 |
| 2000-06-30 | vs COL | 78 | L 4-5 | 35-43 | 5 | 34,811 | Brian Tollberg | Pedro Astacio | Pedro Astacio | Carlos Almanzar | Jose Jimenez | 390 | 407 | -17 |
| 2000-07-01 | vs COL | 79 | W 5-3 | 36-43 | 5 | 34,941 | Brian Meadows | Rolando Arrojo | Brian Meadows | Rolando Arrojo | Trevor Hoffman | 395 | 410 | -15 |
| 2000-07-02 | vs COL | 80 | L 2-3 | 36-44 | 5 | 22,873 | Woody Williams | Kevin Jarvis | Mike DeJean | Trevor Hoffman | Jose Jimenez | 397 | 413 | -16 |
| 2000-07-03 | vs COL | 81 | L 1-3 | 36-45 | 5 | 31,717 | Adam Eaton | Brian Bohanon | Brian Bohanon | Steve Montgomery | Jose Jimenez | 398 | 416 | -18 |
| 2000-07-04 | vs LAN | 82 | W 7-2 | 37-45 | 5 | 51,285 | Matt Clement | Chan Ho Park | Matt Clement | Chan Ho Park | | 405 | 418 | -13 |
| 2000-07-05 | vs LAN | 83 | L 5-7 | 37-46 | 5 | 27,002 | Brian Tollberg | Darren Dreifort | Antonio Osuna | Matt Whiteside | Mike Fetters | 410 | 425 | -15 |
| 2000-07-06 | vs LAN | 84 | L 3-9 | 37-47 | 5 | 30,902 | Brian Meadows | Kevin Brown | Kevin Brown | Brian Meadows | | 413 | 434 | -21 |
| 2000-07-07 | @ TEX | 85 | L 4-5 | 37-48 | 5 | 35,067 | Woody Williams | Matt Perisho | Doug Davis | Matt Whiteside | | 417 | 439 | -22 |
| 2000-07-08 | @ TEX | 86 | L 1-8 | 37-49 | 5 | 39,143 | Adam Eaton | Rick Helling | Rick Helling | Adam Eaton | | 418 | 447 | -29 |
| 2000-07-09 | @ TEX | 87 | W 4-3 | 38-49 | 5 | 30,070 | Matt Clement | Kenny Rogers | Matt Clement | Kenny Rogers | Trevor Hoffman | 422 | 450 | -28 |
| 2000-07-13 | vs SEA | 88 | W 2-1 | 39-49 | 5 | 21,012 | Brian Tollberg | Freddy Garcia | Trevor Hoffman | Brett Tomko | | 424 | 451 | -27 |
| 2000-07-14 | vs SEA | 89 | L 5-7 | 39-50 | 5 | 26,498 | Brian Meadows | Jamie Moyer | Jamie Moyer | Brian Meadows | Kazuhiro Sasaki | 429 | 458 | -29 |
| 2000-07-15 | vs SEA | 90 | W 4-1 | 40-50 | 5 | 43,532 | Woody Williams | Aaron Sele | Woody Williams | Aaron Sele | Trevor Hoffman | 433 | 459 | -26 |
| 2000-07-16 | vs ANA | 91 | W 6-5 | 41-50 | 5 | 28,941 | Adam Eaton | Jarrod Washburn | Donne Wall | Al Levine | | 439 | 464 | -25 |
| 2000-07-17 | vs ANA | 92 | L 2-3 | 41-51 | 5 | 19,930 | Matt Clement | Brian Cooper | Brian Cooper | Matt Clement | Troy Percival | 441 | 467 | -26 |
| 2000-07-18 | vs ANA | 93 | L 2-3 | 41-52 | 5 | 21,835 | Brian Tollberg | Ken Hill | Al Levine | Trevor Hoffman | | 443 | 470 | -27 |
| 2000-07-19 | @ SFN | 94 | W 4-3 | 42-52 | 5 | 40,930 | Brian Meadows | Mark Gardner | Donne Wall | Alan Embree | | 447 | 473 | -26 |
| 2000-07-20 | @ SFN | 95 | L 3-7 | 42-53 | 5 | 40,930 | Woody Williams | Kirk Rueter | Kirk Rueter | Woody Williams | Aaron Fultz | 450 | 480 | -30 |
| 2000-07-21 | @ COL | 96 | W 5-1 | 43-53 | 5 | 41,118 | Adam Eaton | Brian Bohanon | Adam Eaton | Brian Bohanon | | 455 | 481 | -26 |
| 2000-07-22 | @ COL | 97 | L 4-9 | 43-54 | 5 | 46,085 | Matt Clement | Kevin Jarvis | Gabe White | Matt Clement | | 459 | 490 | -31 |
| 2000-07-23 | @ COL | 98 | W 6-4 | 44-54 | 5 | 40,251 | Brian Tollberg | Pedro Astacio | Trevor Hoffman | Stan Belinda | Donne Wall | 465 | 494 | -29 |
| 2000-07-24 | vs SFN | 99 | L 0-3 | 44-55 | 5 | 22,405 | Brian Meadows | Mark Gardner | Mark Gardner | Brian Meadows | Robb Nen | 465 | 497 | -32 |
| 2000-07-25 | vs SFN | 100 | W 3-2 | 45-55 | 5 | 25,039 | Woody Williams | Kirk Rueter | Woody Williams | Kirk Rueter | Trevor Hoffman | 468 | 499 | -31 |
| 2000-07-26 | vs SFN | 101 | L 1-3 | 45-56 | 5 | 27,172 | Adam Eaton | Shawn Estes | Shawn Estes | Adam Eaton | Robb Nen | 469 | 502 | -33 |
| 2000-07-28 | @ PIT | 102 | L 5-16 | 45-57 | 5 | 20,686 | Matt Clement | Bronson Arroyo | Bronson Arroyo | Matt Clement | | 474 | 518 | -44 |
| 2000-07-29 | @ PIT | 103 | L 2-10 | 45-58 | 5 | 30,118 | Brian Tollberg | Francisco Cordova | Francisco Cordova | Brian Tollberg | | 476 | 528 | -52 |
| 2000-07-30 | @ PIT | 104 | W 9-8 | 46-58 | 5 | 19,680 | Brian Meadows | Kris Benson | Donne Wall | Marc Wilkins | Trevor Hoffman | 485 | 536 | -51 |
| 2000-07-31 | vs PHI | 105 | W 4-1 | 47-58 | 5 | 43,207 | Woody Williams | Bruce Chen | Woody Williams | Bruce Chen | | 489 | 537 | -48 |
| 2000-08-01 | vs PHI | 106 | W 10-9 | 48-58 | 5 | 18,274 | Adam Eaton | Robert Person | Carlos Almanzar | Jeff Brantley | | 499 | 546 | -47 |
| 2000-08-02 | vs PHI | 107 | W 5-2 | 49-58 | 5 | 14,447 | Matt Clement | Omar Daal | Matt Clement | Omar Daal | Trevor Hoffman | 504 | 548 | -44 |
| 2000-08-03 | vs CHN | 108 | W 6-5 | 50-58 | 5 | 28,878 | Brian Tollberg | Phil Norton | Kevin Walker | Tim Worrell | Trevor Hoffman | 510 | 553 | -43 |
| 2000-08-04 | vs CHN | 109 | W 11-9 | 51-58 | 5 | 30,619 | Jay Witasick | Jon Lieber | Carlos Almanzar | Steve Rain | Trevor Hoffman | 521 | 562 | -41 |
| 2000-08-05 | vs CHN | 110 | L 3-6 | 51-59 | 5 | 46,153 | Woody Williams | Kevin Tapani | Kevin Tapani | Woody Williams | Rick Aguilera | 524 | 568 | -44 |
| 2000-08-06 | vs CHN | 111 | W 8-6 | 52-59 | 5 | 33,271 | Adam Eaton | Daniel Garibay | Adam Eaton | Daniel Garibay | Trevor Hoffman | 532 | 574 | -42 |
| 2000-08-07 | @ PHI | 112 | W 6-4 | 53-59 | 5 | 13,353 | Matt Clement | Robert Person | Matt Clement | Robert Person | Trevor Hoffman | 538 | 578 | -40 |
| 2000-08-08 | @ PHI | 113 | L 4-10 | 53-60 | 5 | 14,181 | Brian Tollberg | Omar Daal | Omar Daal | Brian Tollberg | | 542 | 588 | -46 |
| 2000-08-09 | @ PHI | 114 | L 2-3 | 53-61 | 5 | 16,541 | Jay Witasick | Kent Bottenfield | Chris Brock | Heathcliff Slocumb | | 544 | 591 | -47 |
| 2000-08-10 | @ PHI | 115 | W 15-3 | 54-61 | 5 | 15,681 | Woody Williams | Randy Wolf | Woody Williams | Randy Wolf | | 559 | 594 | -35 |
| 2000-08-11 | @ FLO | 116 | W 3-0 | 55-61 | 5 | 14,663 | Adam Eaton | A.J. Burnett | Adam Eaton | A.J. Burnett | Trevor Hoffman | 562 | 594 | -32 |
| 2000-08-12 | @ FLO | 117 | W 2-1 | 56-61 | 5 | 16,926 | Matt Clement | Chuck Smith | Kevin Walker | Antonio Alfonseca | Trevor Hoffman | 564 | 595 | -31 |
| 2000-08-13 | @ FLO | 118 | W 7-3 | 57-61 | 5 | 11,496 | Brian Tollberg | Reid Cornelius | Kevin Walker | Armando Almanza | Trevor Hoffman | 571 | 598 | -27 |
| 2000-08-14 | @ ATL | 119 | L 2-9 | 57-62 | 5 | 31,316 | Jay Witasick | Tom Glavine | Tom Glavine | Jay Witasick | | 573 | 607 | -34 |
| 2000-08-15 | @ ATL | 120 | L 1-3 | 57-63 | 5 | 33,543 | Woody Williams | John Burkett | Mike Remlinger | Woody Williams | John Rocker | 574 | 610 | -36 |
| 2000-08-16 | @ ATL | 121 | L 1-4 | 57-64 | 5 | 31,650 | Adam Eaton | Kevin Millwood | Scott Kamieniecki | Kevin Walker | John Rocker | 575 | 614 | -39 |
| 2000-08-18 | vs MON | 122 | L 3-6 | 57-65 | 5 | 20,597 | Matt Clement | Mike Thurman | Mike Thurman | Matt Clement | Scott Strickland | 578 | 620 | -42 |
| 2000-08-19 | vs MON | 123 | W 4-3 | 58-65 | 5 | 56,779 | Brian Tollberg | Javier Vazquez | Kevin Walker | Julio Santana | | 582 | 623 | -41 |
| 2000-08-20 | vs MON | 124 | W 5-4 | 59-65 | 5 | 25,343 | Jay Witasick | Felipe Lira | Jay Witasick | Felipe Lira | Trevor Hoffman | 587 | 627 | -40 |
| 2000-08-21 | vs NYN | 125 | W 5-4 | 60-65 | 5 | 21,234 | Woody Williams | Glendon Rusch | Trevor Hoffman | Dennis Cook | | 592 | 631 | -39 |
| 2000-08-22 | vs NYN | 126 | W 16-1 | 61-65 | 5 | 24,919 | Adam Eaton | Pat Mahomes | Adam Eaton | Pat Mahomes | Todd Erdos | 608 | 632 | -24 |
| 2000-08-23 | vs NYN | 127 | L 1-4 | 61-66 | 5 | 26,376 | Matt Clement | Al Leiter | Al Leiter | Matt Clement | Armando Benitez | 609 | 636 | -27 |
| 2000-08-25 | @ MIL | 128 | W 4-0 | 62-66 | 5 | 20,389 | Brian Tollberg | Jamey Wright | Brian Tollberg | Jamey Wright | | 613 | 636 | -23 |
| 2000-08-26 | @ MIL | 129 | L 5-6 | 62-67 | 5 | 20,240 | Jay Witasick | Paul Rigdon | Curt Leskanic | Trevor Hoffman | | 618 | 642 | -24 |
| 2000-08-27 | @ MIL | 130 | W 2-1 | 63-67 | 5 | 21,785 | Woody Williams | John Snyder | Woody Williams | David Weathers | Trevor Hoffman | 620 | 643 | -23 |
| 2000-08-28 | @ CHN | 131 | W 8-2 | 64-67 | 5 | 32,983 | Matt Clement | Ruben Quevedo | Matt Clement | Ruben Quevedo | | 628 | 645 | -17 |
| 2000-08-29 | @ CHN | 132 | L 6-7 | 64-68 | 5 | 31,984 | Adam Eaton | Jamie Arnold | Felix Heredia | Trevor Hoffman | | 634 | 652 | -18 |
| 2000-08-30 | @ CHN | 133 | L 1-5 | 64-69 | 5 | 30,122 | Brian Tollberg | Jon Lieber | Jon Lieber | Brian Tollberg | | 635 | 657 | -22 |
| 2000-08-31 | @ CHN | 134 | W 11-5 | 65-69 | 5 | 25,965 | Jay Witasick | Kevin Tapani | Jay Witasick | Kevin Tapani | | 646 | 662 | -16 |
| 2000-09-01 | vs PIT | 135 | L 2-3 | 65-70 | 5 | 16,813 | Woody Williams | Dan Serafini | Mike Williams | Trevor Hoffman | | 648 | 665 | -17 |
| 2000-09-02 | vs PIT | 136 | L 3-6 | 65-71 | 5 | 33,358 | Matt Clement | Todd Ritchie | Todd Ritchie | Matt Clement | Scott Sauerbeck | 651 | 671 | -20 |
| 2000-09-03 | vs PIT | 137 | L 6-8 | 65-72 | 5 | 20,389 | Adam Eaton | Kris Benson | Matt Skrmetta | Carlos Almanzar | Mike Williams | 657 | 679 | -22 |
| 2000-09-04 | vs MIL | 138 | W 4-3 | 66-72 | 5 | 15,183 | Brian Tollberg | Jamey Wright | Tom Davey | Ray King | Trevor Hoffman | 661 | 682 | -21 |
| 2000-09-05 | vs MIL | 139 | W 3-1 | 67-72 | 5 | 14,001 | Jay Witasick | Paul Rigdon | Jay Witasick | Paul Rigdon | Trevor Hoffman | 664 | 683 | -19 |
| 2000-09-06 | vs MIL | 140 | W 7-6 | 68-72 | 5 | 13,777 | Woody Williams | John Snyder | Woody Williams | John Snyder | Trevor Hoffman | 671 | 689 | -18 |
| 2000-09-07 | @ SFN | 141 | L 0-13 | 68-73 | 5 | 40,930 | Matt Clement | Shawn Estes | Shawn Estes | Matt Clement | | 671 | 702 | -31 |
| 2000-09-08 | @ SFN | 142 | W 10-7 | 69-73 | 5 | 40,930 | Will Cunnane | Livan Hernandez | Carlos Almanzar | Alan Embree | Trevor Hoffman | 681 | 709 | -28 |
| 2000-09-09 | @ SFN | 143 | W 7-3 | 70-73 | 5 | 40,930 | Brian Tollberg | Russ Ortiz | Brian Tollberg | Russ Ortiz | | 688 | 712 | -24 |
| 2000-09-10 | @ SFN | 144 | L 2-10 | 70-74 | 5 | 40,930 | Jay Witasick | Kirk Rueter | Kirk Rueter | Jay Witasick | | 690 | 722 | -32 |
| 2000-09-11 | vs COL | 145 | W 7-2 | 71-74 | 5 | 19,404 | Woody Williams | Julian Tavarez | Woody Williams | Julian Tavarez | | 697 | 724 | -27 |
| 2000-09-12 | vs COL | 146 | L 3-6 | 71-75 | 5 | 15,772 | Matt Clement | Masato Yoshii | Masato Yoshii | Matt Clement | Jose Jimenez | 700 | 730 | -30 |
| 2000-09-13 | vs COL | 147 | L 0-11 | 71-76 | 5 | 13,832 | Adam Eaton | Brian Bohanon | Brian Bohanon | Adam Eaton | | 700 | 741 | -41 |
| 2000-09-15 | vs SFN | 148 | W 5-4 | 72-76 | 5 | 26,600 | Brian Tollberg | Russ Ortiz | Tom Davey | Doug Henry | Trevor Hoffman | 705 | 745 | -40 |
| 2000-09-16 | vs SFN | 149 | L 3-4 | 72-77 | 5 | 55,695 | Jay Witasick | Kirk Rueter | Alan Embree | Carlos Almanzar | Robb Nen | 708 | 749 | -41 |
| 2000-09-17 | vs SFN | 150 | L 1-5 | 72-78 | 5 | 28,673 | Woody Williams | Mark Gardner | Mark Gardner | Woody Williams | | 709 | 754 | -45 |
| 2000-09-19 | @ COL | 151 | W 7-2 | 73-78 | 5 | 36,295 | Matt Clement | Brian Bohanon | Matt Clement | Brian Bohanon | | 716 | 756 | -40 |
| 2000-09-20 | @ COL | 152 | W 15-11 | 74-78 | 5 | 36,088 | Adam Eaton | Brian Rose | Adam Eaton | Brian Rose | Trevor Hoffman | 731 | 767 | -36 |
| 2000-09-21 | @ COL | 153 | L 4-13 | 74-79 | 5 | 36,286 | Brian Tollberg | Kevin Jarvis | Kevin Jarvis | Brian Tollberg | | 735 | 780 | -45 |
| 2000-09-22 | @ LAN | 154 | W 3-2 | 75-79 | 5 | 37,512 | Jay Witasick | Eric Gagne | Dave Maurer | Antonio Osuna | Trevor Hoffman | 738 | 782 | -44 |
| 2000-09-23 | @ LAN | 155 | L 1-2 | 75-80 | 5 | 40,623 | Woody Williams | Kevin Brown | Kevin Brown | Woody Williams | | 739 | 784 | -45 |
| 2000-09-24 | @ LAN | 156 | L 0-1 | 75-81 | 5 | 46,393 | Matt Clement | Chan Ho Park | Chan Ho Park | Matt Clement | Jeff Shaw | 739 | 785 | -46 |
| 2000-09-26 | vs SLN | 157 | L 1-7 | 75-82 | 5 | 29,722 | Adam Eaton | Andy Benes | Andy Benes | Adam Eaton | | 740 | 792 | -52 |
| 2000-09-27 | vs SLN | 158 | L 0-3 | 75-83 | 5 | 28,500 | Brian Tollberg | Rick Ankiel | Rick Ankiel | Brian Tollberg | Dave Veres | 740 | 795 | -55 |
| 2000-09-28 | vs SLN | 159 | L 6-7 | 75-84 | 5 | 30,093 | Jay Witasick | Darryl Kile | Darryl Kile | Tom Davey | Dave Veres | 746 | 802 | -56 |
| 2000-09-29 | vs LAN | 160 | L 0-3 | 75-85 | 5 | 40,382 | Woody Williams | Chan Ho Park | Chan Ho Park | Woody Williams | | 746 | 805 | -59 |
| 2000-09-30 | vs LAN | 161 | L 2-10 | 75-86 | 5 | 50,267 | Matt Clement | Eric Gagne | Eric Gagne | Matt Clement | | 748 | 815 | -67 |
| 2000-10-01 | vs LAN | 162 | W 4-0 | 76-86 | 5 | 43,691 | Adam Eaton | Darren Dreifort | Adam Eaton | Darren Dreifort | Trevor Hoffman | 752 | 815 | -63 |