| West | W | L | Pct | GB |
| Oakland | 91 | 70 | .565 | -- |
| Seattle | 91 | 71 | .562 | 0.5 |
| Anaheim | 82 | 80 | .506 | 9.5 |
| Texas | 71 | 91 | .438 | 20.5 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2000-04-03 | Kevin Appier | R | 32 | W 4-7 | vs DET | 1 | 282 | L | 6.0 | 8 | 6 | 3 | 1 | 4 | 7 | 112 | 46 | 66 | 59% | 0-1 | 4.50 | 2.00 |
| 2000-04-04 | Tim Hudson | R | 25 | L 3-1 | vs DET | 1 | 22 | W | 7.0 | 1 | 0 | 0 | 0 | 3 | 8 | 104 | 41 | 63 | 61% | 1-0 | 0.00 | 0.57 |
| 2000-04-05 | Omar Olivares | R | 33 | L 8-2 | vs DET | 1 | 202 | W | 7.1 | 6 | 2 | 2 | 0 | 3 | 2 | 103 | 42 | 61 | 59% | 1-0 | 2.57 | 1.29 |
| 2000-04-07 | Gil Heredia | R | 34 | W 6-7 | vs CHA | 1 | 79 | - | 6.0 | 4 | 2 | 2 | 0 | 4 | 8 | 103 | 40 | 63 | 61% | 0-0 | 3.00 | 1.33 |
| 2000-04-08 | Ron Mahay | L | 29 | W 3-7 | vs CHA | 1 | 2 | L | 4.0 | 9 | 6 | 6 | 1 | 2 | 2 | 81 | 34 | 47 | 58% | 0-1 | 13.50 | 2.75 |
| 2000-04-09 | Kevin Appier | R | 32 | L 14-2 | vs CHA | 2 | 283 | W | 6.2 | 5 | 2 | 2 | 1 | 2 | 3 | 105 | 39 | 66 | 63% | 1-1 | 3.46 | 1.46 |
| 2000-04-10 | Tim Hudson | R | 25 | W 4-9 | vs CLE | 2 | 23 | - | 5.0 | 5 | 4 | 4 | 0 | 6 | 2 | 112 | 59 | 53 | 47% | 1-0 | 3.00 | 1.25 |
| 2000-04-11 | Omar Olivares | R | 33 | W 1-5 | vs CLE | 2 | 203 | L | 5.2 | 6 | 5 | 4 | 1 | 4 | 2 | 102 | 51 | 51 | 50% | 1-1 | 4.15 | 1.46 |
| 2000-04-12 | Gil Heredia | R | 34 | W 0-5 | vs CLE | 2 | 80 | L | 6.0 | 6 | 4 | 4 | 0 | 2 | 3 | 90 | 31 | 59 | 66% | 0-1 | 4.50 | 1.33 |
| 2000-04-14 | Kevin Appier | R | 32 | W 13-6 | @ BOS | 3 | 284 | W | 6.0 | 8 | 4 | 3 | 0 | 1 | 6 | 94 | 30 | 64 | 68% | 2-1 | 3.79 | 1.47 |
| 2000-04-15 | Tim Hudson | R | 25 | L 2-14 | @ BOS | 3 | 24 | L | 1.2 | 6 | 7 | 7 | 0 | 4 | 1 | 64 | 28 | 36 | 56% | 1-1 | 7.07 | 1.79 |
| 2000-04-16 | Omar Olivares | R | 33 | L 4-5 | @ BOS | 3 | 204 | - | 7.0 | 7 | 4 | 4 | 0 | 1 | 2 | 99 | 44 | 55 | 56% | 1-1 | 4.50 | 1.35 |
| 2000-04-17 | Gil Heredia | R | 34 | W 1-0 | @ BOS | 3 | 81 | W | 7.0 | 3 | 0 | 0 | 0 | 3 | 4 | 103 | 42 | 61 | 59% | 1-1 | 2.84 | 1.16 |
| 2000-04-18 | Mark Mulder | L | 23 | W 8-5 | @ CLE | 1 | 1 | W | 6.0 | 5 | 4 | 4 | 2 | 3 | 6 | 102 | 42 | 60 | 59% | 1-0 | 6.00 | 1.33 |
| 2000-04-19 | Kevin Appier | R | 32 | W 10-5 | @ CLE | 4 | 285 | W | 5.0 | 7 | 3 | 3 | 1 | 6 | 3 | 125 | 53 | 72 | 58% | 3-1 | 4.13 | 1.71 |
| 2000-04-20 | Tim Hudson | R | 25 | L 5-9 | @ CLE | 4 | 25 | L | 2.1 | 5 | 4 | 4 | 2 | 1 | 3 | 60 | 28 | 32 | 53% | 1-2 | 8.44 | 1.94 |
| 2000-04-21 | Omar Olivares | R | 33 | W 9-11 | vs BAL | 4 | 205 | L | 5.2 | 9 | 6 | 5 | 0 | 3 | 2 | 88 | 37 | 51 | 58% | 1-2 | 5.19 | 1.50 |
| 2000-04-22 | Gil Heredia | R | 34 | W 3-4 | vs BAL | 4 | 82 | L | 6.0 | 8 | 4 | 3 | 1 | 4 | 4 | 105 | 42 | 63 | 60% | 1-2 | 3.24 | 1.36 |
| 2000-04-23 | Mark Mulder | L | 23 | L 3-2 | vs BAL | 2 | 2 | - | 7.0 | 4 | 2 | 2 | 0 | 2 | 4 | 103 | 42 | 61 | 59% | 1-0 | 4.15 | 1.08 |
| 2000-04-24 | Kevin Appier | R | 32 | W 2-3 | vs TOR | 5 | 286 | L | 7.1 | 6 | 3 | 3 | 0 | 3 | 3 | 110 | 44 | 66 | 60% | 3-2 | 4.06 | 1.61 |
| 2000-04-25 | Tim Hudson | R | 25 | L 11-2 | vs TOR | 5 | 26 | W | 7.0 | 2 | 1 | 1 | 1 | 2 | 8 | 99 | 38 | 61 | 62% | 2-2 | 6.26 | 1.52 |
| 2000-04-26 | Omar Olivares | R | 33 | W 2-4 | vs TOR | 5 | 206 | L | 6.0 | 8 | 3 | 3 | 0 | 2 | 3 | 100 | 38 | 62 | 62% | 1-3 | 5.06 | 1.53 |
| 2000-04-28 | Gil Heredia | R | 35 | W 5-2 | @ MIN | 5 | 83 | W | 6.0 | 5 | 2 | 0 | 0 | 2 | 3 | 83 | 32 | 51 | 61% | 2-2 | 2.61 | 1.32 |
| 2000-04-29 | Mark Mulder | L | 23 | W 6-2 | @ MIN | 3 | 3 | - | 6.2 | 8 | 2 | 2 | 0 | 4 | 4 | 104 | 41 | 63 | 61% | 1-0 | 3.60 | 1.30 |
| 2000-04-30 | Tim Hudson | R | 25 | W 8-2 | @ MIN | 6 | 27 | W | 7.2 | 6 | 2 | 2 | 0 | 1 | 10 | 115 | 40 | 75 | 65% | 3-2 | 5.23 | 1.35 |
| 2000-05-01 | Omar Olivares | R | 33 | W 7-5 | @ KCA | 6 | 207 | W | 7.0 | 8 | 5 | 5 | 0 | 3 | 4 | 110 | 45 | 65 | 59% | 2-3 | 5.31 | 1.54 |
| 2000-05-02 | Ron Mahay | L | 29 | L 7-8 | @ KCA | 2 | 3 | - | 3.1 | 7 | 5 | 5 | 2 | 2 | 0 | 74 | 29 | 45 | 61% | 0-1 | 9.00 | 2.19 |
| 2000-05-03 | Gil Heredia | R | 35 | W 14-5 | @ KCA | 6 | 84 | W | 6.1 | 11 | 2 | 2 | 1 | 1 | 3 | 100 | 34 | 66 | 66% | 3-2 | 2.68 | 1.43 |
| 2000-05-05 | Mark Mulder | L | 23 | L 16-17 | @ TEX | 4 | 4 | - | 4.1 | 7 | 7 | 7 | 0 | 3 | 4 | 77 | 33 | 44 | 57% | 1-0 | 5.63 | 1.50 |
| 2000-05-06 | Tim Hudson | R | 25 | L 10-11 | @ TEX | 7 | 28 | - | 6.0 | 9 | 6 | 4 | 1 | 4 | 3 | 121 | 47 | 74 | 61% | 3-2 | 5.35 | 1.49 |
| 2000-05-07 | Omar Olivares | R | 33 | W 7-6 | @ TEX | 7 | 208 | W | 7.1 | 9 | 5 | 4 | 2 | 3 | 3 | 98 | 43 | 55 | 56% | 3-3 | 5.28 | 1.57 |
| 2000-05-08 | Ariel Prieto | R | 31 | L 8-9 | @ ANA | 1 | 55 | - | 4.0 | 11 | 5 | 5 | 1 | 0 | 2 | 74 | 23 | 51 | 69% | 0-0 | 11.25 | 2.75 |
| 2000-05-09 | Gil Heredia | R | 35 | W 5-2 | @ ANA | 7 | 85 | W | 7.0 | 5 | 1 | 1 | 1 | 2 | 2 | 95 | 41 | 54 | 57% | 4-2 | 2.45 | 1.36 |
| 2000-05-10 | Mark Mulder | L | 23 | W 7-4 | @ ANA | 5 | 5 | - | 7.2 | 6 | 2 | 2 | 1 | 1 | 6 | 112 | 45 | 67 | 60% | 1-0 | 4.78 | 1.34 |
| 2000-05-11 | Tim Hudson | R | 25 | L 7-6 | vs SEA | 8 | 29 | W | 7.0 | 7 | 6 | 6 | 3 | 3 | 7 | 111 | 47 | 64 | 58% | 4-2 | 5.73 | 1.48 |
| 2000-05-12 | Omar Olivares | R | 33 | L 9-7 | vs SEA | 8 | 209 | - | 6.0 | 6 | 6 | 6 | 1 | 4 | 4 | 111 | 50 | 61 | 55% | 3-3 | 5.71 | 1.58 |
| 2000-05-13 | Kevin Appier | R | 32 | W 4-6 | vs SEA | 6 | 287 | L | 5.2 | 5 | 5 | 3 | 1 | 4 | 5 | 108 | 45 | 63 | 58% | 3-3 | 4.14 | 1.59 |
| 2000-05-14 | Gil Heredia | R | 35 | L 7-2 | vs SEA | 8 | 86 | W | 5.2 | 7 | 2 | 2 | 0 | 0 | 3 | 95 | 31 | 64 | 67% | 5-2 | 2.52 | 1.34 |
| 2000-05-15 | Mark Mulder | L | 23 | L 6-3 | vs KCA | 6 | 6 | W | 6.0 | 6 | 3 | 1 | 0 | 0 | 2 | 74 | 24 | 50 | 68% | 2-0 | 4.26 | 1.29 |
| 2000-05-16 | Tim Hudson | R | 25 | W 7-8 | vs KCA | 9 | 30 | - | 5.0 | 6 | 4 | 3 | 0 | 6 | 7 | 97 | 40 | 57 | 59% | 4-2 | 5.69 | 1.57 |
| 2000-05-17 | Omar Olivares | R | 33 | W 3-4 | vs KCA | 9 | 210 | L | 5.2 | 5 | 4 | 2 | 0 | 2 | 3 | 86 | 33 | 53 | 62% | 3-4 | 5.43 | 1.53 |
| 2000-05-18 | Kevin Appier | R | 32 | W 5-10 | vs MIN | 7 | 288 | - | 3.0 | 9 | 5 | 2 | 0 | 1 | 2 | 69 | 24 | 45 | 65% | 3-3 | 4.28 | 1.73 |
| 2000-05-19 | Gil Heredia | R | 35 | W 2-3 | vs MIN | 9 | 87 | L | 8.0 | 8 | 3 | 3 | 1 | 5 | 2 | 110 | 47 | 63 | 57% | 5-3 | 2.64 | 1.38 |
| 2000-05-20 | Mark Mulder | L | 23 | W 0-3 | vs MIN | 7 | 7 | L | 7.0 | 7 | 3 | 1 | 0 | 4 | 4 | 109 | 43 | 66 | 61% | 2-1 | 3.80 | 1.33 |
| 2000-05-21 | Tim Hudson | R | 25 | L 13-4 | vs MIN | 10 | 31 | W | 7.0 | 4 | 0 | 0 | 0 | 4 | 6 | 110 | 50 | 60 | 55% | 5-2 | 4.98 | 1.52 |
| 2000-05-23 | Omar Olivares | R | 33 | L 4-6 | @ TBA | 10 | 211 | L | 6.0 | 10 | 6 | 6 | 1 | 4 | 4 | 101 | 42 | 59 | 58% | 3-5 | 5.77 | 1.61 |
| 2000-05-24 | Kevin Appier | R | 32 | W 9-2 | @ TBA | 8 | 289 | W | 6.0 | 4 | 2 | 2 | 1 | 3 | 8 | 93 | 35 | 58 | 62% | 4-3 | 4.11 | 1.65 |
| 2000-05-25 | Gil Heredia | R | 35 | W 6-3 | @ TBA | 10 | 88 | W | 7.0 | 5 | 1 | 1 | 0 | 2 | 3 | 103 | 43 | 60 | 58% | 6-3 | 2.49 | 1.34 |
| 2000-05-26 | Mark Mulder | L | 23 | L 3-8 | @ BAL | 8 | 8 | L | 5.1 | 10 | 6 | 6 | 4 | 3 | 2 | 90 | 36 | 54 | 60% | 2-2 | 4.50 | 1.46 |
| 2000-05-27 | Tim Hudson | R | 25 | W 4-0 | @ BAL | 11 | 32 | W | 7.1 | 1 | 0 | 0 | 0 | 4 | 5 | 112 | 53 | 59 | 53% | 6-2 | 4.43 | 1.43 |
| 2000-05-29 | Omar Olivares | R | 33 | L 1-4 | @ NYA | 11 | 212 | L | 8.0 | 6 | 4 | 4 | 1 | 2 | 3 | 123 | 46 | 77 | 63% | 3-6 | 5.63 | 1.54 |
| 2000-05-30 | Kevin Appier | R | 32 | W 7-4 | @ NYA | 9 | 290 | W | 5.0 | 9 | 4 | 4 | 3 | 5 | 4 | 98 | 41 | 57 | 58% | 5-3 | 4.41 | 1.76 |
| 2000-05-31 | Gil Heredia | R | 35 | W 8-7 | @ NYA | 11 | 89 | W | 5.2 | 7 | 6 | 6 | 2 | 3 | 3 | 94 | 37 | 57 | 61% | 7-3 | 3.04 | 1.37 |
| 2000-06-02 | Mark Mulder | L | 23 | L 5-4 | vs SFN | 9 | 9 | W | 5.0 | 7 | 3 | 3 | 2 | 3 | 4 | 98 | 43 | 55 | 56% | 3-2 | 4.58 | 1.51 |
| 2000-06-03 | Tim Hudson | R | 25 | L 9-7 | vs SFN | 12 | 33 | - | 6.0 | 7 | 5 | 5 | 3 | 1 | 6 | 108 | 41 | 67 | 62% | 6-2 | 4.70 | 1.42 |
| 2000-06-04 | Omar Olivares | R | 33 | W 2-18 | vs SFN | 12 | 213 | L | 4.1 | 10 | 8 | 8 | 3 | 0 | 3 | 72 | 31 | 41 | 57% | 3-7 | 6.28 | 1.59 |
| 2000-06-05 | Kevin Appier | R | 32 | L 3-2 | vs SDN | 10 | 291 | - | 7.0 | 3 | 2 | 2 | 1 | 7 | 5 | 123 | 47 | 76 | 62% | 5-3 | 4.19 | 1.72 |
| 2000-06-06 | Gil Heredia | R | 35 | L 5-4 | vs SDN | 12 | 90 | W | 7.0 | 5 | 4 | 3 | 0 | 1 | 6 | 96 | 25 | 71 | 74% | 8-3 | 3.12 | 1.32 |
| 2000-06-07 | Mark Mulder | L | 23 | L 10-4 | vs SDN | 10 | 10 | - | 4.1 | 5 | 4 | 4 | 1 | 3 | 1 | 57 | 22 | 35 | 61% | 3-2 | 4.88 | 1.54 |
| 2000-06-09 | Tim Hudson | R | 25 | W 3-1 | @ LAN | 13 | 34 | - | 6.1 | 4 | 1 | 1 | 1 | 4 | 8 | 102 | 48 | 54 | 53% | 6-2 | 4.44 | 1.41 |
| 2000-06-10 | Omar Olivares | R | 33 | L 2-7 | @ LAN | 13 | 214 | L | 4.0 | 9 | 6 | 6 | 1 | 4 | 4 | 89 | 39 | 50 | 56% | 3-8 | 6.64 | 1.68 |
| 2000-06-11 | Kevin Appier | R | 33 | W 6-0 | @ LAN | 11 | 292 | W | 9.0 | 7 | 0 | 0 | 0 | 1 | 6 | 122 | 46 | 76 | 62% | 6-3 | 3.63 | 1.61 |
| 2000-06-12 | Gil Heredia | R | 35 | L 2-7 | @ MIN | 13 | 91 | L | 4.0 | 4 | 7 | 6 | 1 | 2 | 5 | 81 | 34 | 47 | 58% | 8-4 | 3.62 | 1.33 |
| 2000-06-13 | Mark Mulder | L | 23 | W 6-5 | @ MIN | 11 | 11 | W | 6.0 | 8 | 2 | 2 | 0 | 4 | 3 | 99 | 45 | 54 | 55% | 4-2 | 4.71 | 1.58 |
| 2000-06-14 | Tim Hudson | R | 25 | W 9-6 | @ MIN | 14 | 35 | W | 8.0 | 3 | 1 | 1 | 1 | 3 | 7 | 118 | 49 | 69 | 58% | 7-2 | 4.12 | 1.35 |
| 2000-06-16 | Omar Olivares | R | 33 | W 8-3 | @ KCA | 14 | 215 | - | 0.0 | 0 | 0 | 0 | 0 | 1 | 0 | 8 | 4 | 4 | 50% | 3-8 | 6.64 | 1.69 |
| 2000-06-17 | Kevin Appier | R | 33 | W 10-4 | @ KCA | 12 | 293 | W | 7.0 | 7 | 4 | 4 | 1 | 2 | 1 | 110 | 44 | 66 | 60% | 7-3 | 3.77 | 1.58 |
| 2000-06-18 | Gil Heredia | R | 35 | W 21-3 | @ KCA | 14 | 92 | W | 7.0 | 7 | 3 | 3 | 0 | 1 | 2 | 81 | 26 | 55 | 68% | 9-4 | 3.64 | 1.31 |
| 2000-06-19 | Mark Mulder | L | 23 | L 13-12 | vs BAL | 12 | 12 | - | 2.1 | 7 | 6 | 6 | 1 | 2 | 2 | 52 | 21 | 31 | 60% | 4-2 | 5.29 | 1.65 |
| 2000-06-20 | Tim Hudson | R | 25 | L 8-5 | vs BAL | 15 | 36 | W | 8.0 | 8 | 5 | 5 | 3 | 0 | 3 | 98 | 33 | 65 | 66% | 8-2 | 4.25 | 1.32 |
| 2000-06-21 | Ariel Prieto | R | 31 | L 10-3 | vs BAL | 2 | 56 | W | 5.0 | 5 | 2 | 1 | 0 | 2 | 2 | 97 | 48 | 49 | 51% | 1-0 | 6.00 | 2.00 |
| 2000-06-23 | Kevin Appier | R | 33 | L 10-6 | vs KCA | 13 | 294 | W | 6.1 | 8 | 5 | 5 | 0 | 5 | 6 | 120 | 56 | 64 | 53% | 8-3 | 4.05 | 1.63 |
| 2000-06-24 | Gil Heredia | R | 35 | W 3-8 | vs KCA | 15 | 93 | L | 5.1 | 8 | 6 | 6 | 1 | 1 | 3 | 86 | 32 | 54 | 63% | 9-5 | 4.02 | 1.34 |
| 2000-06-25 | Mark Mulder | L | 23 | L 4-3 | vs KCA | 13 | 13 | W | 7.0 | 4 | 1 | 1 | 0 | 2 | 4 | 98 | 41 | 57 | 58% | 5-2 | 4.92 | 1.57 |
| 2000-06-27 | Tim Hudson | R | 25 | L 7-6 | vs TEX | 16 | 37 | W | 5.0 | 3 | 3 | 3 | 1 | 2 | 4 | 64 | 27 | 37 | 58% | 9-2 | 4.31 | 1.30 |
| 2000-06-28 | Kevin Appier | R | 33 | W 3-5 | vs TEX | 14 | 295 | L | 7.0 | 8 | 5 | 5 | 0 | 1 | 1 | 111 | 40 | 71 | 64% | 8-4 | 4.24 | 1.60 |
| 2000-06-29 | Gil Heredia | R | 35 | W 1-3 | vs TEX | 16 | 94 | L | 9.0 | 9 | 3 | 3 | 1 | 2 | 2 | 115 | 42 | 73 | 63% | 9-6 | 3.93 | 1.33 |
| 2000-06-30 | Mark Mulder | L | 23 | L 0-7 | @ ANA | 14 | 14 | L | 5.2 | 10 | 6 | 6 | 2 | 2 | 0 | 88 | 34 | 54 | 61% | 5-3 | 5.29 | 1.63 |
| 2000-07-01 | Ariel Prieto | R | 31 | L 2-7 | @ ANA | 3 | 57 | L | 4.0 | 4 | 5 | 3 | 1 | 5 | 2 | 93 | 44 | 49 | 53% | 1-1 | 6.23 | 2.08 |
| 2000-07-02 | Tim Hudson | R | 25 | W 10-3 | @ ANA | 17 | 38 | W | 7.0 | 6 | 2 | 2 | 0 | 2 | 6 | 117 | 46 | 71 | 61% | 10-2 | 4.19 | 1.29 |
| 2000-07-03 | Kevin Appier | R | 33 | L 3-8 | @ TEX | 15 | 296 | L | 7.0 | 5 | 4 | 3 | 2 | 5 | 4 | 146 | 58 | 88 | 60% | 8-5 | 4.21 | 1.59 |
| 2000-07-04 | Gil Heredia | R | 35 | L 7-10 | @ TEX | 17 | 95 | - | 3.2 | 9 | 6 | 2 | 1 | 2 | 1 | 77 | 36 | 41 | 53% | 9-6 | 3.95 | 1.38 |
| 2000-07-05 | Mark Mulder | L | 23 | L 4-9 | @ TEX | 15 | 15 | L | 6.2 | 15 | 9 | 2 | 0 | 3 | 7 | 134 | 50 | 84 | 63% | 5-4 | 5.07 | 1.70 |
| 2000-07-07 | Tim Hudson | R | 25 | L 5-4 | vs ARI | 18 | 39 | - | 6.1 | 6 | 4 | 4 | 0 | 4 | 5 | 112 | 54 | 58 | 52% | 10-2 | 4.25 | 1.30 |
| 2000-07-08 | Kevin Appier | R | 33 | L 8-7 | vs ARI | 16 | 297 | - | 7.0 | 5 | 5 | 5 | 0 | 2 | 4 | 109 | 41 | 68 | 62% | 8-5 | 4.37 | 1.54 |
| 2000-07-09 | Gil Heredia | R | 35 | W 2-4 | vs ARI | 18 | 96 | L | 6.0 | 11 | 4 | 3 | 1 | 3 | 0 | 109 | 44 | 65 | 60% | 9-7 | 3.98 | 1.43 |
| 2000-07-13 | Mark Mulder | L | 23 | L 2-4 | @ SFN | 16 | 16 | L | 6.0 | 4 | 2 | 2 | 1 | 2 | 2 | 91 | 42 | 49 | 54% | 5-5 | 4.94 | 1.66 |
| 2000-07-14 | Kevin Appier | R | 33 | L 2-4 | @ SFN | 17 | 298 | L | 7.0 | 9 | 3 | 3 | 1 | 1 | 1 | 88 | 37 | 51 | 58% | 8-6 | 4.33 | 1.54 |
| 2000-07-15 | Gil Heredia | R | 35 | W 6-2 | @ SFN | 19 | 97 | W | 6.2 | 7 | 2 | 2 | 1 | 1 | 6 | 106 | 33 | 73 | 69% | 10-7 | 3.93 | 1.43 |
| 2000-07-17 | Marcus Jones | R | 25 | W 11-10 | @ COL | 1 | 1 | - | 2.1 | 5 | 4 | 4 | 1 | 3 | 1 | 69 | 32 | 37 | 54% | 0-0 | 18.00 | 4.00 |
| 2000-07-17 | Ariel Prieto | R | 31 | L 9-10 | @ COL | 4 | 58 | - | 6.0 | 4 | 2 | 2 | 0 | 0 | 6 | 83 | 24 | 59 | 71% | 1-1 | 5.21 | 1.63 |
| 2000-07-18 | Mark Mulder | L | 23 | L 3-18 | @ COL | 17 | 17 | L | 4.0 | 9 | 10 | 9 | 0 | 3 | 2 | 85 | 35 | 50 | 59% | 5-6 | 5.57 | 1.71 |
| 2000-07-19 | Kevin Appier | R | 33 | W 3-6 | vs SEA | 18 | 299 | L | 6.0 | 10 | 6 | 6 | 0 | 5 | 4 | 122 | 58 | 64 | 52% | 8-7 | 4.58 | 1.59 |
| 2000-07-20 | Gil Heredia | R | 35 | L 5-4 | vs SEA | 20 | 98 | W | 7.0 | 6 | 1 | 1 | 1 | 4 | 2 | 118 | 51 | 67 | 57% | 11-7 | 3.79 | 1.43 |
| 2000-07-21 | Tim Hudson | R | 25 | W 3-12 | vs ANA | 19 | 40 | L | 5.1 | 12 | 9 | 9 | 3 | 3 | 4 | 108 | 45 | 63 | 58% | 10-3 | 4.77 | 1.37 |
| 2000-07-22 | Barry Zito | L | 22 | L 10-3 | vs ANA | 1 | 1 | W | 5.0 | 2 | 1 | 1 | 0 | 6 | 6 | 103 | 51 | 52 | 50% | 1-0 | 1.80 | 1.60 |
| 2000-07-23 | Mark Mulder | L | 23 | L 5-0 | vs ANA | 18 | 18 | W | 7.2 | 6 | 0 | 0 | 0 | 2 | 5 | 123 | 50 | 73 | 59% | 6-6 | 5.14 | 1.66 |
| 2000-07-24 | Kevin Appier | R | 33 | L 4-6 | @ SEA | 19 | 300 | L | 6.0 | 9 | 5 | 5 | 1 | 6 | 5 | 128 | 58 | 70 | 55% | 8-8 | 4.73 | 1.63 |
| 2000-07-25 | Gil Heredia | R | 35 | W 8-7 | @ SEA | 21 | 99 | W | 6.1 | 7 | 4 | 4 | 2 | 0 | 4 | 103 | 34 | 69 | 67% | 12-7 | 3.86 | 1.41 |
| 2000-07-26 | Tim Hudson | R | 25 | W 6-1 | @ SEA | 20 | 41 | W | 7.1 | 7 | 1 | 1 | 0 | 4 | 5 | 126 | 54 | 72 | 57% | 11-3 | 4.57 | 1.39 |
| 2000-07-27 | Barry Zito | L | 22 | W 4-5 | vs BOS | 2 | 2 | - | 7.0 | 4 | 3 | 3 | 1 | 4 | 5 | 99 | 41 | 58 | 59% | 1-0 | 3.00 | 1.33 |
| 2000-07-28 | Mark Mulder | L | 23 | W 1-4 | vs BOS | 19 | 19 | L | 8.0 | 6 | 4 | 3 | 2 | 3 | 3 | 109 | 45 | 64 | 59% | 6-7 | 5.02 | 1.62 |
| 2000-07-29 | Kevin Appier | R | 33 | L 12-1 | vs BOS | 20 | 301 | W | 7.0 | 4 | 0 | 0 | 0 | 3 | 7 | 111 | 42 | 69 | 62% | 9-8 | 4.46 | 1.60 |
| 2000-07-30 | Gil Heredia | R | 35 | L 5-2 | vs BOS | 22 | 100 | W | 7.1 | 4 | 2 | 2 | 2 | 1 | 1 | 79 | 23 | 56 | 71% | 13-7 | 3.79 | 1.37 |
| 2000-07-31 | Tim Hudson | R | 25 | L 6-1 | vs TOR | 21 | 42 | W | 8.0 | 3 | 1 | 1 | 1 | 1 | 5 | 106 | 38 | 68 | 64% | 12-3 | 4.36 | 1.33 |
| 2000-08-01 | Barry Zito | L | 22 | L 3-1 | vs TOR | 3 | 3 | - | 7.0 | 4 | 1 | 1 | 0 | 2 | 3 | 108 | 45 | 63 | 58% | 1-0 | 2.37 | 1.16 |
| 2000-08-02 | Mark Mulder | L | 23 | L 5-4 | vs TOR | 20 | 20 | - | 6.0 | 8 | 2 | 2 | 1 | 1 | 2 | 78 | 35 | 43 | 55% | 6-7 | 4.92 | 1.61 |
| 2000-08-04 | Kevin Appier | R | 33 | W 5-3 | @ CHA | 21 | 302 | W | 6.1 | 6 | 2 | 2 | 1 | 4 | 2 | 124 | 59 | 65 | 52% | 10-8 | 4.40 | 1.60 |
| 2000-08-05 | Gil Heredia | R | 35 | L 3-4 | @ CHA | 23 | 101 | - | 6.2 | 7 | 2 | 2 | 1 | 1 | 1 | 84 | 32 | 52 | 62% | 13-7 | 3.73 | 1.36 |
| 2000-08-06 | Tim Hudson | R | 25 | L 0-13 | @ CHA | 22 | 43 | L | 2.2 | 7 | 8 | 7 | 0 | 4 | 1 | 88 | 42 | 46 | 52% | 12-4 | 4.74 | 1.38 |
| 2000-08-08 | Barry Zito | L | 22 | L 3-4 | @ NYA | 4 | 4 | - | 6.1 | 3 | 2 | 1 | 0 | 2 | 4 | 84 | 36 | 48 | 57% | 1-0 | 2.16 | 1.08 |
| 2000-08-09 | Kevin Appier | R | 33 | L 1-12 | @ NYA | 22 | 303 | L | 3.2 | 7 | 10 | 10 | 2 | 6 | 2 | 94 | 43 | 51 | 54% | 10-9 | 4.93 | 1.65 |
| 2000-08-10 | Mark Mulder | L | 23 | L 6-12 | @ NYA | 21 | 21 | L | 3.1 | 11 | 10 | 10 | 2 | 3 | 1 | 77 | 36 | 41 | 53% | 6-8 | 5.53 | 1.69 |
| 2000-08-11 | Gil Heredia | R | 35 | W 4-11 | vs DET | 24 | 102 | L | 4.2 | 8 | 7 | 6 | 0 | 5 | 2 | 88 | 40 | 48 | 55% | 13-8 | 3.99 | 1.41 |
| 2000-08-12 | Tim Hudson | R | 25 | L 9-5 | vs DET | 23 | 44 | W | 6.0 | 5 | 4 | 4 | 1 | 2 | 3 | 84 | 30 | 54 | 64% | 13-4 | 4.79 | 1.37 |
| 2000-08-13 | Barry Zito | L | 22 | W 3-5 | vs DET | 5 | 5 | L | 6.0 | 7 | 5 | 5 | 2 | 2 | 5 | 100 | 38 | 62 | 62% | 1-1 | 3.19 | 1.16 |
| 2000-08-14 | Kevin Appier | R | 33 | L 8-1 | vs CLE | 23 | 304 | W | 6.0 | 8 | 1 | 1 | 1 | 4 | 3 | 111 | 47 | 64 | 58% | 11-9 | 4.78 | 1.66 |
| 2000-08-15 | Mark Mulder | L | 23 | L 5-3 | vs CLE | 22 | 22 | W | 6.0 | 5 | 2 | 2 | 0 | 3 | 2 | 102 | 42 | 60 | 59% | 7-8 | 5.41 | 1.67 |
| 2000-08-16 | Gil Heredia | R | 35 | L 7-6 | vs CLE | 25 | 103 | - | 6.0 | 6 | 5 | 5 | 2 | 3 | 4 | 102 | 43 | 59 | 58% | 13-8 | 4.13 | 1.41 |
| 2000-08-18 | Tim Hudson | R | 25 | L 1-10 | @ DET | 24 | 45 | L | 3.2 | 7 | 6 | 5 | 2 | 2 | 3 | 103 | 48 | 55 | 53% | 13-5 | 4.97 | 1.40 |
| 2000-08-19 | Barry Zito | L | 22 | L 3-4 | @ DET | 6 | 6 | L | 6.0 | 9 | 4 | 4 | 0 | 1 | 5 | 106 | 37 | 69 | 65% | 1-2 | 3.65 | 1.24 |
| 2000-08-20 | Kevin Appier | R | 33 | W 5-4 | @ DET | 24 | 305 | - | 7.0 | 3 | 1 | 1 | 0 | 3 | 4 | 109 | 47 | 62 | 57% | 11-9 | 4.62 | 1.63 |
| 2000-08-21 | Mark Mulder | L | 23 | L 1-3 | @ DET | 23 | 23 | L | 5.2 | 6 | 3 | 3 | 0 | 2 | 5 | 107 | 46 | 61 | 57% | 7-9 | 5.37 | 1.66 |
| 2000-08-22 | Gil Heredia | R | 35 | L 6-14 | @ CLE | 26 | 104 | L | 3.0 | 8 | 7 | 6 | 1 | 2 | 2 | 81 | 33 | 48 | 59% | 13-9 | 4.39 | 1.45 |
| 2000-08-23 | Tim Hudson | R | 25 | L 5-7 | @ CLE | 25 | 46 | L | 5.1 | 8 | 7 | 7 | 1 | 1 | 5 | 79 | 30 | 49 | 62% | 13-6 | 5.23 | 1.41 |
| 2000-08-24 | Barry Zito | L | 22 | W 11-7 | @ CLE | 7 | 7 | W | 6.2 | 5 | 3 | 2 | 0 | 6 | 8 | 130 | 57 | 73 | 56% | 2-2 | 3.48 | 1.30 |
| 2000-08-25 | Kevin Appier | R | 33 | L 8-1 | vs NYA | 25 | 306 | W | 8.0 | 4 | 1 | 0 | 0 | 4 | 8 | 127 | 58 | 69 | 54% | 12-9 | 4.39 | 1.59 |
| 2000-08-26 | Mark Mulder | L | 23 | W 6-10 | vs NYA | 24 | 24 | L | 2.0 | 10 | 6 | 6 | 1 | 1 | 1 | 50 | 16 | 34 | 68% | 7-10 | 5.69 | 1.71 |
| 2000-08-27 | Gil Heredia | R | 35 | W 5-7 | vs NYA | 27 | 105 | - | 6.1 | 6 | 3 | 3 | 0 | 2 | 2 | 98 | 41 | 57 | 58% | 13-9 | 4.37 | 1.44 |
| 2000-08-28 | Tim Hudson | R | 25 | L 3-0 | vs CHA | 26 | 47 | W | 9.0 | 1 | 0 | 0 | 0 | 1 | 8 | 106 | 37 | 69 | 65% | 14-6 | 4.93 | 1.34 |
| 2000-08-29 | Barry Zito | L | 22 | W 0-3 | vs CHA | 8 | 8 | L | 7.0 | 4 | 3 | 3 | 1 | 4 | 5 | 106 | 41 | 65 | 61% | 2-3 | 3.53 | 1.27 |
| 2000-08-30 | Kevin Appier | R | 33 | W 3-8 | vs CHA | 26 | 307 | L | 6.1 | 7 | 4 | 4 | 0 | 2 | 5 | 102 | 42 | 60 | 59% | 12-10 | 4.45 | 1.59 |
| 2000-09-01 | Mark Mulder | L | 23 | L 3-4 | @ TOR | 25 | 25 | - | 5.1 | 9 | 3 | 3 | 0 | 4 | 5 | 106 | 48 | 58 | 55% | 7-10 | 5.68 | 1.74 |
| 2000-09-02 | Gil Heredia | R | 35 | W 8-0 | @ TOR | 28 | 106 | W | 7.1 | 4 | 0 | 0 | 0 | 3 | 4 | 97 | 34 | 63 | 65% | 14-9 | 4.19 | 1.42 |
| 2000-09-03 | Tim Hudson | R | 25 | W 4-3 | @ TOR | 27 | 48 | W | 7.2 | 8 | 2 | 2 | 0 | 0 | 5 | 108 | 35 | 73 | 68% | 15-6 | 4.80 | 1.33 |
| 2000-09-04 | Barry Zito | L | 22 | W 10-0 | @ TOR | 9 | 9 | W | 6.2 | 2 | 0 | 0 | 0 | 6 | 4 | 115 | 53 | 62 | 54% | 3-3 | 3.10 | 1.26 |
| 2000-09-05 | Kevin Appier | R | 33 | L 3-10 | @ BOS | 27 | 308 | L | 2.2 | 9 | 8 | 8 | 1 | 3 | 1 | 68 | 26 | 42 | 62% | 12-11 | 4.80 | 1.63 |
| 2000-09-06 | Mark Mulder | L | 23 | W 6-4 | @ BOS | 26 | 26 | W | 6.0 | 5 | 2 | 2 | 2 | 3 | 2 | 85 | 37 | 48 | 56% | 8-10 | 5.57 | 1.73 |
| 2000-09-08 | Gil Heredia | R | 35 | W 0-4 | vs TBA | 29 | 107 | L | 9.0 | 5 | 4 | 2 | 1 | 0 | 4 | 111 | 33 | 78 | 70% | 14-10 | 4.08 | 1.38 |
| 2000-09-09 | Tim Hudson | R | 25 | L 10-0 | vs TBA | 28 | 49 | W | 9.0 | 2 | 0 | 0 | 0 | 0 | 4 | 94 | 30 | 64 | 68% | 16-6 | 4.55 | 1.27 |
| 2000-09-10 | Barry Zito | L | 22 | L 11-0 | vs TBA | 10 | 10 | W | 9.0 | 5 | 0 | 0 | 0 | 0 | 8 | 110 | 32 | 78 | 71% | 4-3 | 2.69 | 1.16 |
| 2000-09-11 | Kevin Appier | R | 33 | L 5-1 | vs TBA | 28 | 309 | W | 8.0 | 5 | 1 | 1 | 0 | 0 | 5 | 99 | 33 | 66 | 67% | 13-11 | 4.63 | 1.59 |
| 2000-09-12 | Mark Mulder | L | 23 | L 5-3 | vs MIN | 27 | 27 | W | 7.0 | 3 | 2 | 2 | 0 | 3 | 5 | 96 | 35 | 61 | 64% | 9-10 | 5.44 | 1.69 |
| 2000-09-13 | Gil Heredia | R | 35 | W 6-7 | vs MIN | 30 | 108 | L | 4.0 | 9 | 4 | 3 | 1 | 1 | 2 | 70 | 24 | 46 | 66% | 14-11 | 4.14 | 1.40 |
| 2000-09-15 | Barry Zito | L | 22 | W 17-3 | @ TBA | 11 | 11 | W | 6.0 | 3 | 2 | 2 | 1 | 5 | 4 | 92 | 41 | 51 | 55% | 5-3 | 2.71 | 1.18 |
| 2000-09-16 | Tim Hudson | R | 25 | W 5-2 | @ TBA | 29 | 50 | W | 6.2 | 6 | 2 | 2 | 0 | 4 | 6 | 120 | 49 | 71 | 59% | 17-6 | 4.50 | 1.28 |
| 2000-09-18 | Kevin Appier | R | 33 | W 12-3 | @ BAL | 29 | 310 | W | 5.1 | 7 | 3 | 3 | 1 | 3 | 4 | 99 | 46 | 53 | 54% | 14-11 | 4.65 | 1.60 |
| 2000-09-19 | Ariel Prieto | R | 31 | W 7-4 | @ BAL | 5 | 59 | - | 4.2 | 9 | 3 | 3 | 0 | 0 | 3 | 70 | 27 | 43 | 61% | 1-1 | 5.00 | 1.67 |
| 2000-09-20 | Barry Zito | L | 22 | L 0-2 | @ BAL | 12 | 12 | L | 7.2 | 4 | 2 | 2 | 1 | 5 | 4 | 110 | 48 | 62 | 56% | 5-4 | 2.70 | 1.19 |
| 2000-09-20 | Gil Heredia | R | 35 | W 4-0 | @ BAL | 31 | 109 | W | 7.2 | 7 | 0 | 0 | 0 | 0 | 6 | 94 | 25 | 69 | 73% | 15-11 | 3.97 | 1.38 |
| 2000-09-21 | Tim Hudson | R | 25 | W 5-2 | @ SEA | 30 | 51 | W | 6.0 | 5 | 2 | 1 | 0 | 3 | 6 | 107 | 42 | 65 | 61% | 18-6 | 4.40 | 1.28 |
| 2000-09-22 | Omar Olivares | R | 33 | W 8-3 | @ SEA | 15 | 216 | W | 5.0 | 4 | 2 | 2 | 0 | 2 | 4 | 76 | 28 | 48 | 63% | 4-8 | 6.82 | 1.78 |
| 2000-09-23 | Kevin Appier | R | 33 | W 8-2 | @ SEA | 30 | 311 | W | 7.0 | 1 | 2 | 2 | 1 | 4 | 7 | 117 | 50 | 67 | 57% | 15-11 | 4.57 | 1.57 |
| 2000-09-24 | Ariel Prieto | R | 31 | L 2-3 | @ SEA | 6 | 60 | L | 5.0 | 6 | 3 | 3 | 1 | 4 | 1 | 90 | 37 | 53 | 59% | 1-2 | 5.06 | 1.72 |
| 2000-09-25 | Barry Zito | L | 22 | L 7-5 | vs ANA | 13 | 13 | W | 6.1 | 7 | 3 | 3 | 0 | 1 | 10 | 96 | 29 | 67 | 70% | 6-4 | 2.79 | 1.18 |
| 2000-09-26 | Tim Hudson | R | 25 | L 10-3 | vs ANA | 31 | 52 | W | 8.0 | 5 | 2 | 2 | 0 | 1 | 5 | 112 | 41 | 71 | 63% | 19-6 | 4.31 | 1.26 |
| 2000-09-27 | Gil Heredia | R | 35 | L 9-7 | vs ANA | 32 | 110 | - | 4.0 | 8 | 5 | 5 | 1 | 3 | 4 | 81 | 31 | 50 | 62% | 15-11 | 4.12 | 1.41 |
| 2000-09-28 | Kevin Appier | R | 33 | W 3-6 | vs ANA | 31 | 312 | - | 8.0 | 7 | 3 | 3 | 2 | 2 | 3 | 109 | 39 | 70 | 64% | 15-11 | 4.52 | 1.55 |
| 2000-09-29 | Omar Olivares | R | 33 | L 7-5 | vs TEX | 16 | 217 | - | 5.0 | 6 | 3 | 3 | 0 | 5 | 4 | 99 | 40 | 59 | 60% | 4-8 | 6.75 | 1.80 |
| 2000-09-30 | Barry Zito | L | 22 | L 23-2 | vs TEX | 14 | 14 | W | 6.0 | 5 | 1 | 1 | 0 | 1 | 7 | 100 | 38 | 62 | 62% | 7-4 | 2.71 | 1.17 |
| 2000-10-01 | Tim Hudson | R | 25 | L 3-0 | vs TEX | 32 | 53 | W | 8.0 | 4 | 0 | 0 | 0 | 2 | 10 | 120 | 49 | 71 | 59% | 20-6 | 4.14 | 1.24 |