| 2000-03-29 | vs CHN | 1 | L 3-5 | 0-1 | 4 | 55,000 | Mike Hampton | Jon Lieber | Jon Lieber | Mike Hampton | Rick Aguilera | 3 | 5 | -2 |
| 2000-03-30 | @ CHN | 2 | W 5-1 | 1-1 | 1 | 55,000 | Rick Reed | Kyle Farnsworth | Dennis Cook | Danny Young | | 8 | 6 | 2 |
| 2000-04-03 | vs SDN | 3 | W 2-1 | 2-1 | 3 | 52,308 | Al Leiter | Sterling Hitchcock | Al Leiter | Donne Wall | Armando Benitez | 10 | 7 | 3 |
| 2000-04-05 | vs SDN | 4 | L 0-4 | 2-2 | 2 | 17,585 | Robert Joseph Jones | Woody Williams | Woody Williams | Robert Joseph Jones | | 10 | 11 | -1 |
| 2000-04-06 | vs SDN | 5 | L 5-8 | 2-3 | 4 | 17,482 | Mike Hampton | Matt Clement | Matt Clement | Mike Hampton | | 15 | 19 | -4 |
| 2000-04-07 | vs LAN | 6 | W 2-1 | 3-3 | 3 | 27,791 | Rick Reed | Darren Dreifort | Rick Reed | Darren Dreifort | Armando Benitez | 17 | 20 | -3 |
| 2000-04-08 | vs LAN | 7 | L 5-6 | 3-4 | 4 | 37,814 | Pat Mahomes | Kevin Brown | Mike Fetters | Armando Benitez | Jeff Shaw | 22 | 26 | -4 |
| 2000-04-10 | @ PHI | 8 | L 7-9 | 3-5 | 5 | 47,115 | Robert Joseph Jones | Paul Byrd | Amaury Telemaco | Rich Rodriguez | Wayne Gomes | 29 | 35 | -6 |
| 2000-04-12 | @ PHI | 9 | L 5-8 | 3-6 | 5 | 15,269 | Mike Hampton | Robert Person | Robert Person | Mike Hampton | Wayne Gomes | 34 | 43 | -9 |
| 2000-04-13 | @ PHI | 10 | W 2-1 | 4-6 | 5 | 14,552 | Rick Reed | Randy Wolf | Dennis Cook | Scott Aldred | Armando Benitez | 36 | 44 | -8 |
| 2000-04-14 | @ PIT | 11 | W 8-5 | 5-6 | 4 | 20,725 | Al Leiter | Jason Schmidt | John Franco | Jose Silva | | 44 | 49 | -5 |
| 2000-04-15 | @ PIT | 12 | L 0-2 | 5-7 | 4 | 19,592 | Glendon Rusch | Jimmy Anderson | Jimmy Anderson | Glendon Rusch | Mike Williams | 44 | 51 | -7 |
| 2000-04-16 | @ PIT | 13 | W 12-9 | 6-7 | 4 | 20,724 | Robert Joseph Jones | Kris Benson | Pat Mahomes | Chris Peters | Armando Benitez | 56 | 60 | -4 |
| 2000-04-18 | vs MIL | 14 | W 10-7 | 7-7 | 4 | 17,905 | Mike Hampton | Jaime Navarro | Mike Hampton | Jaime Navarro | Armando Benitez | 66 | 67 | -1 |
| 2000-04-19 | vs MIL | 15 | W 3-1 | 8-7 | 4 | 18,001 | Rick Reed | Jason Bere | Rick Reed | Jason Bere | Armando Benitez | 69 | 68 | 1 |
| 2000-04-20 | vs MIL | 16 | W 5-4 | 9-7 | 3 | 17,002 | Al Leiter | Steve Woodard | Turk Wendell | Curt Leskanic | | 74 | 72 | 2 |
| 2000-04-22 | vs CHN | 17 | W 8-3 | 11-7 | 2 | 0 | Glendon Rusch | Jon Lieber | Glendon Rusch | Jon Lieber | | 82 | 75 | 7 |
| 2000-04-22 | vs CHN | 18 | W 7-6 | 11-7 | 2 | 32,204 | Dennis Springer | Kyle Farnsworth | Dennis Cook | Kyle Farnsworth | Armando Benitez | 89 | 81 | 8 |
| 2000-04-23 | vs CHN | 19 | W 15-8 | 12-7 | 2 | 27,560 | Mike Hampton | Kevin Tapani | Mike Hampton | Kevin Tapani | | 104 | 89 | 15 |
| 2000-04-24 | vs LAN | 20 | W 1-0 | 13-7 | 2 | 37,987 | Pat Mahomes | Darren Dreifort | Armando Benitez | Terry Adams | | 105 | 89 | 16 |
| 2000-04-25 | vs CIN | 21 | W 6-5 | 14-7 | 2 | 27,153 | Al Leiter | Rob Bell | Turk Wendell | Scott Sullivan | Armando Benitez | 111 | 94 | 17 |
| 2000-04-26 | vs CIN | 22 | L 1-12 | 14-8 | 2 | 33,371 | Dennis Springer | Denny Neagle | Denny Neagle | Dennis Springer | | 112 | 106 | 6 |
| 2000-04-27 | vs CIN | 23 | L 1-2 | 14-9 | 2 | 50,971 | Glendon Rusch | Steve Parris | Danny Graves | Armando Benitez | Scott Sullivan | 113 | 108 | 5 |
| 2000-04-28 | @ COL | 24 | L 5-12 | 14-10 | 3 | 45,366 | Mike Hampton | Pedro Astacio | Pedro Astacio | Mike Hampton | | 118 | 120 | -2 |
| 2000-04-29 | @ COL | 25 | W 13-6 | 15-10 | 2 | 41,220 | Rick Reed | Masato Yoshii | Rick Reed | Masato Yoshii | | 131 | 126 | 5 |
| 2000-04-30 | @ COL | 26 | W 14-11 | 16-10 | 2 | 36,252 | Al Leiter | Brian Bohanon | Al Leiter | Brian Bohanon | | 145 | 137 | 8 |
| 2000-05-01 | @ SFN | 27 | L 3-10 | 16-11 | 2 | 40,930 | Bill Pulsipher | Shawn Estes | Shawn Estes | Bill Pulsipher | | 148 | 147 | 1 |
| 2000-05-02 | @ SFN | 28 | L 1-7 | 16-12 | 2 | 40,930 | Glendon Rusch | Livan Hernandez | Livan Hernandez | Glendon Rusch | | 149 | 154 | -5 |
| 2000-05-03 | @ SFN | 29 | L 5-8 | 16-13 | 2 | 40,930 | Mike Hampton | Russ Ortiz | Felix Rodriguez | Turk Wendell | | 154 | 162 | -8 |
| 2000-05-04 | @ SFN | 30 | L 2-7 | 16-14 | 3 | 40,930 | Rick Reed | Kirk Rueter | Felix Rodriguez | Rick Reed | | 156 | 169 | -13 |
| 2000-05-05 | @ FLO | 31 | W 4-1 | 17-14 | 3 | 30,229 | Al Leiter | Jesus Sanchez | Al Leiter | Jesus Sanchez | John Franco | 160 | 170 | -10 |
| 2000-05-06 | @ FLO | 32 | L 1-9 | 17-15 | 3 | 33,401 | Bill Pulsipher | Alex Fernandez | Alex Fernandez | Bill Pulsipher | | 161 | 179 | -18 |
| 2000-05-07 | @ FLO | 33 | L 0-3 | 17-16 | 3 | 25,147 | Glendon Rusch | Ryan Dempster | Ryan Dempster | Glendon Rusch | | 161 | 182 | -21 |
| 2000-05-09 | @ PIT | 34 | W 2-0 | 18-16 | 3 | 14,015 | Mike Hampton | Kris Benson | Mike Hampton | Kris Benson | Armando Benitez | 163 | 182 | -19 |
| 2000-05-10 | @ PIT | 35 | L 9-13 | 18-17 | 4 | 13,711 | Rick Reed | Todd Ritchie | Jose Silva | Dennis Cook | | 172 | 195 | -23 |
| 2000-05-11 | @ PIT | 36 | W 3-2 | 19-17 | 4 | 16,264 | Al Leiter | Jimmy Anderson | Al Leiter | Jimmy Anderson | | 175 | 197 | -22 |
| 2000-05-12 | vs FLO | 37 | L 4-6 | 19-18 | 4 | 30,828 | Glendon Rusch | Ryan Dempster | Ryan Dempster | Glendon Rusch | Antonio Alfonseca | 179 | 203 | -24 |
| 2000-05-13 | vs FLO | 38 | L 6-7 | 19-19 | 4 | 32,772 | Pat Mahomes | Vladimir Nunez | Ron Mahay | Dennis Cook | Antonio Alfonseca | 185 | 210 | -25 |
| 2000-05-14 | vs FLO | 39 | W 5-1 | 20-19 | 4 | 36,162 | Mike Hampton | Brad Penny | Mike Hampton | Brad Penny | | 190 | 211 | -21 |
| 2000-05-16 | vs COL | 40 | L 3-4 | 20-20 | 4 | 25,697 | Rick Reed | Masato Yoshii | Julian Tavarez | Turk Wendell | Jose Jimenez | 193 | 215 | -22 |
| 2000-05-17 | vs COL | 41 | W 4-2 | 21-20 | 4 | 23,665 | Al Leiter | Rolando Arrojo | Al Leiter | Rolando Arrojo | John Franco | 197 | 217 | -20 |
| 2000-05-19 | vs ARI | 42 | W 4-3 | 22-20 | 3 | 25,292 | Robert Joseph Jones | Todd Stottlemyre | Robert Joseph Jones | Todd Stottlemyre | Armando Benitez | 201 | 220 | -19 |
| 2000-05-20 | vs ARI | 43 | W 8-7 | 23-20 | 3 | 37,121 | Mike Hampton | Omar Daal | Mike Hampton | Omar Daal | Armando Benitez | 209 | 227 | -18 |
| 2000-05-21 | vs ARI | 44 | W 7-6 | 24-20 | 3 | 38,826 | Rick Reed | Randy Johnson | Turk Wendell | Byung-Hyun Kim | | 216 | 233 | -17 |
| 2000-05-22 | @ SDN | 45 | L 0-1 | 24-21 | 3 | 17,966 | Glendon Rusch | Matt Clement | Matt Clement | John Franco | Trevor Hoffman | 216 | 234 | -18 |
| 2000-05-23 | @ SDN | 46 | W 5-3 | 25-21 | 3 | 25,783 | Al Leiter | Stan Spencer | Turk Wendell | Trevor Hoffman | Armando Benitez | 221 | 237 | -16 |
| 2000-05-24 | @ SDN | 47 | L 4-5 | 25-22 | 3 | 19,405 | Robert Joseph Jones | Brian Meadows | Donne Wall | Pat Mahomes | Trevor Hoffman | 225 | 242 | -17 |
| 2000-05-26 | @ SLN | 48 | W 5-2 | 26-22 | 3 | 40,028 | Mike Hampton | Pat Hentgen | Mike Hampton | Mark Thompson | Armando Benitez | 230 | 244 | -14 |
| 2000-05-27 | @ SLN | 49 | W 12-8 | 27-22 | 2 | 48,690 | Rick Reed | Andy Benes | Dennis Cook | Dave Veres | | 242 | 252 | -10 |
| 2000-05-28 | @ SLN | 50 | W 6-2 | 28-22 | 2 | 46,344 | Glendon Rusch | Darryl Kile | Glendon Rusch | Darryl Kile | | 248 | 254 | -6 |
| 2000-05-29 | @ LAN | 51 | L 1-4 | 28-23 | 2 | 43,084 | Al Leiter | Chan Ho Park | Chan Ho Park | Al Leiter | | 249 | 258 | -9 |
| 2000-05-30 | @ LAN | 52 | W 10-5 | 29-23 | 2 | 26,102 | Robert Joseph Jones | Eric Gagne | John Franco | Jeff Shaw | | 259 | 263 | -4 |
| 2000-05-31 | @ LAN | 53 | L 3-4 | 29-24 | 2 | 31,323 | Mike Hampton | Kevin Brown | Mike Fetters | Turk Wendell | | 262 | 267 | -5 |
| 2000-06-02 | vs TBA | 54 | W 5-3 | 30-24 | 2 | 24,123 | Glendon Rusch | Albie Lopez | Glendon Rusch | Rick White | Armando Benitez | 267 | 270 | -3 |
| 2000-06-03 | vs TBA | 55 | W 1-0 | 31-24 | 2 | 33,694 | Al Leiter | Steve Trachsel | Al Leiter | Steve Trachsel | Armando Benitez | 268 | 270 | -2 |
| 2000-06-04 | vs TBA | 56 | L 5-15 | 31-25 | 3 | 43,610 | Robert Joseph Jones | Esteban Yan | Esteban Yan | Robert Joseph Jones | | 273 | 285 | -12 |
| 2000-06-05 | vs BAL | 57 | L 2-4 | 31-26 | 3 | 25,192 | Mike Hampton | Mike Mussina | Mike Mussina | Mike Hampton | Mike Timlin | 275 | 289 | -14 |
| 2000-06-07 | vs BAL | 58 | W 11-3 | 32-26 | 3 | 34,492 | Rick Reed | Scott Erickson | Pat Mahomes | Scott Erickson | | 286 | 292 | -6 |
| 2000-06-08 | vs BAL | 59 | W 8-7 | 33-26 | 2 | 9,540 | Glendon Rusch | Jason Johnson | Dennis Cook | Jose Mercedes | | 294 | 299 | -5 |
| 2000-06-09 | @ NYA | 60 | W 12-2 | 34-26 | 2 | 55,822 | Al Leiter | Roger Clemens | Al Leiter | Roger Clemens | | 306 | 301 | 5 |
| 2000-06-10 | @ NYA | 61 | L 5-13 | 34-27 | 2 | 55,839 | Robert Joseph Jones | Andy Pettitte | Andy Pettitte | Robert Joseph Jones | | 311 | 314 | -3 |
| 2000-06-13 | @ CHN | 62 | L 3-4 | 34-28 | 2 | 38,879 | Rick Reed | Kevin Tapani | Felix Heredia | John Franco | Rick Aguilera | 314 | 318 | -4 |
| 2000-06-14 | @ CHN | 63 | W 10-8 | 35-28 | 2 | 38,625 | Mike Hampton | Scott Downs | Glendon Rusch | Daniel Garibay | Armando Benitez | 324 | 326 | -2 |
| 2000-06-16 | @ MIL | 64 | W 7-1 | 36-28 | 2 | 18,979 | Al Leiter | Jimmy Haynes | Al Leiter | Jimmy Haynes | | 331 | 327 | 4 |
| 2000-06-17 | @ MIL | 65 | L 2-3 | 36-29 | 2 | 26,125 | Glendon Rusch | John Snyder | John Snyder | Glendon Rusch | Bob Wickman | 333 | 330 | 3 |
| 2000-06-18 | @ MIL | 66 | W 7-3 | 37-29 | 2 | 20,133 | Rick Reed | Jason Bere | Rick Reed | Jason Bere | | 340 | 333 | 7 |
| 2000-06-20 | vs PHI | 67 | L 2-3 | 37-30 | 2 | 40,386 | Mike Hampton | Paul Byrd | Chris Brock | Armando Benitez | Jeff Brantley | 342 | 336 | 6 |
| 2000-06-21 | vs PHI | 68 | L 5-10 | 37-31 | 2 | 22,524 | Al Leiter | Curt Schilling | Wayne Gomes | John Franco | | 347 | 346 | 1 |
| 2000-06-22 | vs PHI | 69 | W 5-4 | 38-31 | 2 | 21,005 | Glendon Rusch | Cliff Politte | Glendon Rusch | Cliff Politte | Dennis Cook | 352 | 350 | 2 |
| 2000-06-23 | vs PIT | 70 | W 12-2 | 39-31 | 2 | 39,849 | Robert Joseph Jones | Bronson Arroyo | Robert Joseph Jones | Bronson Arroyo | | 364 | 352 | 12 |
| 2000-06-24 | vs PIT | 71 | W 10-8 | 40-31 | 2 | 34,894 | Rick Reed | Jose Silva | John Franco | Rich Loiselle | Armando Benitez | 374 | 360 | 14 |
| 2000-06-25 | vs PIT | 72 | W 9-0 | 41-31 | 2 | 38,984 | Mike Hampton | Kris Benson | Mike Hampton | Kris Benson | | 383 | 360 | 23 |
| 2000-06-26 | vs FLO | 73 | W 10-5 | 42-31 | 2 | 19,657 | Al Leiter | Reid Cornelius | Al Leiter | Reid Cornelius | | 393 | 365 | 28 |
| 2000-06-27 | vs FLO | 74 | W 5-2 | 43-31 | 2 | 22,103 | Glendon Rusch | Jesus Sanchez | Glendon Rusch | Jesus Sanchez | Armando Benitez | 398 | 367 | 31 |
| 2000-06-28 | vs FLO | 75 | W 6-5 | 44-31 | 2 | 37,252 | Robert Joseph Jones | Brad Penny | Robert Joseph Jones | Brad Penny | John Franco | 404 | 372 | 32 |
| 2000-06-29 | vs ATL | 76 | L 4-6 | 44-32 | 2 | 46,998 | Rick Reed | John Burkett | John Burkett | Rick Reed | Kerry Ligtenberg | 408 | 378 | 30 |
| 2000-06-30 | vs ATL | 77 | W 11-8 | 45-32 | 2 | 52,831 | Mike Hampton | Kevin Millwood | Armando Benitez | Terry Mulholland | | 419 | 386 | 33 |
| 2000-07-01 | vs ATL | 78 | W 9-1 | 46-32 | 2 | 44,593 | Al Leiter | Greg Maddux | Al Leiter | Greg Maddux | | 428 | 387 | 41 |
| 2000-07-02 | vs ATL | 79 | L 2-10 | 46-33 | 2 | 45,261 | Glendon Rusch | Tom Glavine | Tom Glavine | Glendon Rusch | | 430 | 397 | 33 |
| 2000-07-03 | @ FLO | 80 | L 0-2 | 46-34 | 2 | 15,844 | Robert Joseph Jones | Jesus Sanchez | Armando Almanza | Turk Wendell | | 430 | 399 | 31 |
| 2000-07-04 | @ FLO | 81 | L 8-9 | 46-35 | 2 | 24,935 | Robert Mitchell Jones | Brad Penny | Vic Darensbourg | Robert Mitchell Jones | Antonio Alfonseca | 438 | 408 | 30 |
| 2000-07-05 | @ FLO | 82 | W 11-2 | 47-35 | 2 | 14,765 | Mike Hampton | Chuck Smith | Mike Hampton | Chuck Smith | | 449 | 410 | 39 |
| 2000-07-07 | vs NYA | 83 | L 1-2 | 47-36 | 2 | 54,132 | Al Leiter | Orlando Hernandez | Orlando Hernandez | Al Leiter | Mariano Rivera | 450 | 412 | 38 |
| 2000-07-08 | vs NYA | 84 | L 2-4 | 47-37 | 2 | 54,165 | Robert Joseph Jones | Dwight Gooden | Dwight Gooden | Robert Joseph Jones | Mariano Rivera | 452 | 416 | 36 |
| 2000-07-08 | @ NYA | 85 | L 2-4 | 47-37 | 2 | 55,821 | Glendon Rusch | Roger Clemens | Roger Clemens | Glendon Rusch | Mariano Rivera | 454 | 420 | 34 |
| 2000-07-09 | vs NYA | 86 | W 2-0 | 48-38 | 2 | 54,286 | Mike Hampton | Andy Pettitte | Mike Hampton | Andy Pettitte | Armando Benitez | 456 | 420 | 36 |
| 2000-07-13 | @ BOS | 87 | L 3-4 | 48-39 | 2 | 33,894 | Robert Joseph Jones | Pedro Martinez | Rich Garces | Armando Benitez | | 459 | 424 | 35 |
| 2000-07-14 | @ BOS | 88 | W 6-4 | 49-39 | 2 | 33,293 | Glendon Rusch | Pete Schourek | Pat Mahomes | Derek Lowe | Armando Benitez | 465 | 428 | 37 |
| 2000-07-15 | @ BOS | 89 | L 4-6 | 49-40 | 2 | 33,213 | Mike Hampton | Ramon Martinez | Ramon Martinez | Mike Hampton | Derek Lowe | 469 | 434 | 35 |
| 2000-07-16 | @ TOR | 90 | L 3-7 | 49-41 | 2 | 30,139 | Al Leiter | Roy Halladay | Roy Halladay | Al Leiter | Billy Koch | 472 | 441 | 31 |
| 2000-07-17 | @ TOR | 91 | W 7-5 | 50-41 | 2 | 23,129 | Rick Reed | Pasqual Coco | John Franco | Pedro Borbon | Armando Benitez | 479 | 446 | 33 |
| 2000-07-18 | @ TOR | 92 | W 11-7 | 51-41 | 2 | 24,633 | Robert Joseph Jones | Chris Carpenter | Robert Joseph Jones | Chris Carpenter | | 490 | 453 | 37 |
| 2000-07-19 | @ MON | 93 | W 5-3 | 52-41 | 2 | 14,198 | Glendon Rusch | Felipe Lira | Pat Mahomes | Steve Kline | Armando Benitez | 495 | 456 | 39 |
| 2000-07-20 | @ MON | 94 | L 1-4 | 52-42 | 2 | 13,641 | Mike Hampton | Dustin Hermanson | Dustin Hermanson | Mike Hampton | Scott Strickland | 496 | 460 | 36 |
| 2000-07-21 | @ ATL | 95 | L 3-6 | 52-43 | 2 | 49,313 | Al Leiter | Terry Mulholland | John Burkett | Al Leiter | Mike Remlinger | 499 | 466 | 33 |
| 2000-07-22 | @ ATL | 96 | W 4-0 | 53-43 | 2 | 48,141 | Rick Reed | Greg Maddux | Rick Reed | Greg Maddux | | 503 | 466 | 37 |
| 2000-07-23 | @ ATL | 97 | L 0-1 | 53-44 | 2 | 46,872 | Robert Joseph Jones | Andy Ashby | Andy Ashby | Robert Joseph Jones | | 503 | 467 | 36 |
| 2000-07-25 | vs MON | 98 | W 5-0 | 54-44 | 2 | 41,028 | Glendon Rusch | Dustin Hermanson | Glendon Rusch | Dustin Hermanson | | 508 | 467 | 41 |
| 2000-07-27 | vs MON | 99 | W 9-8 | 56-44 | 2 | 0 | Grant Roberts | Mike Thurman | John Franco | Scott Strickland | Armando Benitez | 517 | 475 | 42 |
| 2000-07-27 | vs MON | 100 | W 4-3 | 56-44 | 2 | 35,088 | Mike Hampton | Hideki Irabu | Mike Hampton | Hideki Irabu | | 521 | 478 | 43 |
| 2000-07-28 | vs SLN | 101 | W 3-2 | 57-44 | 2 | 42,396 | Al Leiter | Pat Hentgen | Al Leiter | Pat Hentgen | Armando Benitez | 524 | 480 | 44 |
| 2000-07-29 | vs SLN | 102 | W 4-3 | 58-44 | 2 | 50,726 | Rick Reed | Andy Benes | Rick White | Mike James | Armando Benitez | 528 | 483 | 45 |
| 2000-07-30 | vs SLN | 103 | W 4-2 | 59-44 | 2 | 45,733 | Robert Joseph Jones | Garrett Stephenson | Robert Joseph Jones | Garrett Stephenson | | 532 | 485 | 47 |
| 2000-07-31 | vs CIN | 104 | L 0-6 | 59-45 | 2 | 42,774 | Glendon Rusch | Scott Williamson | Scott Williamson | Glendon Rusch | Larry Luebbers | 532 | 491 | 41 |
| 2000-08-01 | vs CIN | 105 | W 3-2 | 60-45 | 2 | 39,572 | Mike Hampton | Steve Parris | Mike Hampton | Steve Parris | Armando Benitez | 535 | 493 | 42 |
| 2000-08-02 | vs CIN | 106 | W 2-1 | 61-45 | 2 | 42,111 | Al Leiter | Elmer Dessens | Al Leiter | Elmer Dessens | Armando Benitez | 537 | 494 | 43 |
| 2000-08-04 | @ ARI | 107 | W 6-1 | 62-45 | 2 | 41,832 | Rick Reed | Randy Johnson | Rick Reed | Randy Johnson | Dennis Cook | 543 | 495 | 48 |
| 2000-08-05 | @ ARI | 108 | W 6-2 | 63-45 | 2 | 41,656 | Robert Joseph Jones | Geraldo Guzman | Robert Joseph Jones | Geraldo Guzman | Rick White | 549 | 497 | 52 |
| 2000-08-06 | @ ARI | 109 | L 5-9 | 63-46 | 2 | 39,641 | Glendon Rusch | Armando Reynoso | Armando Reynoso | Glendon Rusch | Matt Mantei | 554 | 506 | 48 |
| 2000-08-07 | @ HOU | 110 | W 6-5 | 64-46 | 2 | 36,536 | Mike Hampton | Wade Miller | Armando Benitez | Jason Green | | 560 | 511 | 49 |
| 2000-08-08 | @ HOU | 111 | L 3-9 | 64-47 | 2 | 38,031 | Al Leiter | Brian Powell | Brian Powell | Al Leiter | | 563 | 520 | 43 |
| 2000-08-09 | @ HOU | 112 | W 12-5 | 65-47 | 2 | 35,432 | Rick Reed | Jose Lima | Rick Reed | Jose Lima | | 575 | 525 | 50 |
| 2000-08-10 | @ HOU | 113 | W 10-3 | 66-47 | 2 | 37,870 | Robert Joseph Jones | Tony McKnight | Robert Joseph Jones | Tony McKnight | | 585 | 528 | 57 |
| 2000-08-11 | vs SFN | 114 | W 4-1 | 67-47 | 2 | 33,944 | Glendon Rusch | Mark Gardner | Glendon Rusch | Mark Gardner | Armando Benitez | 589 | 529 | 60 |
| 2000-08-12 | vs SFN | 115 | W 3-2 | 68-47 | 2 | 50,064 | Mike Hampton | Shawn Estes | Mike Hampton | Felix Rodriguez | Armando Benitez | 592 | 531 | 61 |
| 2000-08-13 | vs SFN | 116 | W 2-0 | 69-47 | 2 | 39,841 | Al Leiter | Livan Hernandez | Al Leiter | Livan Hernandez | John Franco | 594 | 531 | 63 |
| 2000-08-14 | vs SFN | 117 | L 1-11 | 69-48 | 2 | 35,296 | Rick Reed | Russ Ortiz | Russ Ortiz | Rick Reed | | 595 | 542 | 53 |
| 2000-08-15 | vs COL | 118 | W 7-5 | 71-48 | 2 | 0 | Pat Mahomes | Pedro Astacio | Dennis Cook | Craig House | Armando Benitez | 602 | 547 | 55 |
| 2000-08-15 | vs COL | 119 | W 4-3 | 71-48 | 2 | 29,744 | Robert Joseph Jones | John Wasdin | Robert Joseph Jones | Bobby Chouinard | Armando Benitez | 606 | 550 | 56 |
| 2000-08-16 | vs COL | 120 | L 5-7 | 71-49 | 2 | 29,832 | Glendon Rusch | Brian Bohanon | Brian Bohanon | Glendon Rusch | Gabe White | 611 | 557 | 54 |
| 2000-08-17 | vs COL | 121 | W 13-2 | 72-49 | 2 | 42,697 | Mike Hampton | Masato Yoshii | Turk Wendell | Masato Yoshii | | 624 | 559 | 65 |
| 2000-08-18 | @ LAN | 122 | W 5-3 | 73-49 | 2 | 47,486 | Al Leiter | Kevin Brown | Rick White | Terry Adams | Armando Benitez | 629 | 562 | 67 |
| 2000-08-19 | @ LAN | 123 | L 1-4 | 73-50 | 2 | 53,051 | Rick Reed | Chan Ho Park | Chan Ho Park | Rick Reed | | 630 | 566 | 64 |
| 2000-08-20 | @ LAN | 124 | W 9-6 | 74-50 | 2 | 46,122 | Robert Joseph Jones | Darren Dreifort | Turk Wendell | Terry Adams | Armando Benitez | 639 | 572 | 67 |
| 2000-08-21 | @ SDN | 125 | L 4-5 | 74-51 | 2 | 21,234 | Glendon Rusch | Woody Williams | Trevor Hoffman | Dennis Cook | | 643 | 577 | 66 |
| 2000-08-22 | @ SDN | 126 | L 1-16 | 74-52 | 2 | 24,919 | Pat Mahomes | Adam Eaton | Adam Eaton | Pat Mahomes | Todd Erdos | 644 | 593 | 51 |
| 2000-08-23 | @ SDN | 127 | W 4-1 | 75-52 | 2 | 26,376 | Al Leiter | Matt Clement | Al Leiter | Matt Clement | Armando Benitez | 648 | 594 | 54 |
| 2000-08-25 | vs ARI | 128 | W 13-3 | 76-52 | 2 | 38,237 | Rick Reed | Randy Johnson | Rick Reed | Randy Johnson | | 661 | 597 | 64 |
| 2000-08-26 | vs ARI | 129 | L 1-5 | 76-53 | 2 | 43,985 | Robert Joseph Jones | Brian Anderson | Dan Plesac | Rick White | | 662 | 602 | 60 |
| 2000-08-27 | vs ARI | 130 | W 2-1 | 77-53 | 2 | 42,277 | Mike Hampton | Armando Reynoso | Mike Hampton | Armando Reynoso | Armando Benitez | 664 | 603 | 61 |
| 2000-08-28 | vs HOU | 131 | W 4-2 | 78-53 | 2 | 28,472 | Glendon Rusch | Brian Powell | Glendon Rusch | Brian Powell | Turk Wendell | 668 | 605 | 63 |
| 2000-08-29 | vs HOU | 132 | L 1-11 | 78-54 | 2 | 39,967 | Al Leiter | Wade Miller | Wade Miller | Al Leiter | | 669 | 616 | 53 |
| 2000-08-30 | vs HOU | 133 | W 1-0 | 79-54 | 2 | 42,507 | Rick Reed | Chris Holt | Rick Reed | Chris Holt | Armando Benitez | 670 | 616 | 54 |
| 2000-09-01 | @ SLN | 134 | L 5-6 | 79-55 | 1 | 39,056 | Robert Joseph Jones | Garrett Stephenson | Dave Veres | Pat Mahomes | | 675 | 622 | 53 |
| 2000-09-02 | @ SLN | 135 | L 1-2 | 79-56 | 2 | 41,483 | Mike Hampton | Darryl Kile | Darryl Kile | Mike Hampton | | 676 | 624 | 52 |
| 2000-09-03 | @ SLN | 136 | L 3-4 | 79-57 | 2 | 42,133 | Glendon Rusch | Rick Ankiel | Matt Morris | Rick White | | 679 | 628 | 51 |
| 2000-09-04 | @ CIN | 137 | L 2-6 | 79-58 | 2 | 26,571 | Al Leiter | Elmer Dessens | Elmer Dessens | Al Leiter | | 681 | 634 | 47 |
| 2000-09-05 | @ CIN | 138 | W 3-2 | 80-58 | 2 | 22,664 | Rick Reed | Pete Harnisch | Turk Wendell | Scott Sullivan | Armando Benitez | 684 | 636 | 48 |
| 2000-09-06 | @ CIN | 139 | L 8-11 | 80-59 | 2 | 24,681 | Robert Joseph Jones | Rob Bell | John Riedling | John Franco | Danny Graves | 692 | 647 | 45 |
| 2000-09-08 | vs PHI | 140 | L 0-2 | 80-60 | 2 | 38,808 | Mike Hampton | Bruce Chen | Vicente Padilla | Mike Hampton | Jeff Brantley | 692 | 649 | 43 |
| 2000-09-09 | vs PHI | 141 | L 3-6 | 80-61 | 2 | 42,324 | Glendon Rusch | Robert Person | Robert Person | Turk Wendell | | 695 | 655 | 40 |
| 2000-09-10 | vs PHI | 142 | W 3-0 | 81-61 | 2 | 53,775 | Al Leiter | Omar Daal | Al Leiter | Omar Daal | | 698 | 655 | 43 |
| 2000-09-11 | vs MIL | 143 | L 2-8 | 81-62 | 2 | 21,797 | Rick Reed | Paul Rigdon | Paul Rigdon | Rick Reed | | 700 | 663 | 37 |
| 2000-09-12 | vs MIL | 144 | W 10-2 | 82-62 | 2 | 22,570 | Robert Joseph Jones | John Snyder | Robert Joseph Jones | John Snyder | | 710 | 665 | 45 |
| 2000-09-13 | vs MIL | 145 | W 4-1 | 83-62 | 2 | 22,510 | Mike Hampton | Jeff D'Amico | Armando Benitez | Juan Acevedo | | 714 | 666 | 48 |
| 2000-09-14 | @ MON | 146 | W 10-4 | 84-62 | 2 | 6,219 | Glendon Rusch | Mike Thurman | Glendon Rusch | Mike Thurman | | 724 | 670 | 54 |
| 2000-09-15 | @ MON | 147 | L 3-4 | 84-63 | 2 | 6,979 | Al Leiter | Javier Vazquez | Javier Vazquez | Turk Wendell | Scott Strickland | 727 | 674 | 53 |
| 2000-09-16 | @ MON | 148 | W 10-4 | 85-63 | 2 | 9,045 | Rick Reed | Dustin Hermanson | Rick Reed | Dustin Hermanson | | 737 | 678 | 59 |
| 2000-09-17 | @ MON | 149 | L 0-5 | 85-64 | 2 | 9,349 | Robert Joseph Jones | Tony Armas | Tony Armas | Robert Joseph Jones | | 737 | 683 | 54 |
| 2000-09-18 | @ ATL | 150 | L 3-6 | 85-65 | 2 | 41,937 | Mike Hampton | Greg Maddux | Greg Maddux | Mike Hampton | John Rocker | 740 | 689 | 51 |
| 2000-09-19 | @ ATL | 151 | L 4-12 | 85-66 | 2 | 46,584 | Glendon Rusch | Andy Ashby | Andy Ashby | Glendon Rusch | | 744 | 701 | 43 |
| 2000-09-20 | @ ATL | 152 | W 6-3 | 86-66 | 2 | 48,278 | Al Leiter | Tom Glavine | Al Leiter | Tom Glavine | Armando Benitez | 750 | 704 | 46 |
| 2000-09-21 | @ PHI | 153 | L 5-6 | 86-67 | 2 | 17,769 | Rick Reed | Omar Daal | Jeff Brantley | Rick White | | 755 | 710 | 45 |
| 2000-09-22 | @ PHI | 154 | W 9-6 | 87-67 | 2 | 21,128 | Robert Joseph Jones | Randy Wolf | Robert Joseph Jones | Randy Wolf | Armando Benitez | 764 | 716 | 48 |
| 2000-09-23 | @ PHI | 155 | W 7-3 | 88-67 | 2 | 22,570 | Mike Hampton | Cliff Politte | Mike Hampton | Cliff Politte | | 771 | 719 | 52 |
| 2000-09-24 | @ PHI | 156 | W 3-2 | 89-67 | 2 | 31,391 | Glendon Rusch | Bruce Chen | Glendon Rusch | Bruce Chen | Armando Benitez | 774 | 721 | 53 |
| 2000-09-26 | vs ATL | 157 | L 1-7 | 89-68 | 2 | 48,270 | Al Leiter | John Burkett | John Burkett | Al Leiter | | 775 | 728 | 47 |
| 2000-09-27 | vs ATL | 158 | W 6-2 | 90-68 | 2 | 48,858 | Rick Reed | Kevin Millwood | Rick Reed | Kevin Millwood | | 781 | 730 | 51 |
| 2000-09-28 | vs ATL | 159 | W 8-2 | 91-68 | 2 | 52,134 | Robert Joseph Jones | Greg Maddux | Robert Joseph Jones | Greg Maddux | | 789 | 732 | 57 |
| 2000-09-29 | vs MON | 160 | W 11-2 | 92-68 | 2 | 28,788 | Mike Hampton | Mike Thurman | Mike Hampton | Mike Thurman | | 800 | 734 | 66 |
| 2000-09-30 | vs MON | 161 | W 4-2 | 93-68 | 2 | 39,468 | Glendon Rusch | Javier Vazquez | Turk Wendell | Javier Vazquez | Armando Benitez | 804 | 736 | 68 |
| 2000-10-01 | vs MON | 162 | W 3-2 | 94-68 | 2 | 44,869 | Rick Reed | Dustin Hermanson | Pat Mahomes | Jeremy Powell | | 807 | 738 | 69 |