| 2000-04-03 | vs LAN | 1 | L 4-10 | 0-1 | 4 | 51,249 | Dustin Hermanson | Kevin Brown | Kevin Brown | Dustin Hermanson | Terry Adams | 4 | 10 | -6 |
| 2000-04-04 | vs LAN | 2 | L 4-10 | 0-2 | 4 | 12,143 | Hideki Irabu | Chan Ho Park | Chan Ho Park | Hideki Irabu | | 8 | 20 | -12 |
| 2000-04-05 | vs LAN | 3 | W 6-5 | 1-2 | 4 | 8,867 | Javier Vazquez | Orel Hershiser | Anthony Telford | Jeff Shaw | | 14 | 25 | -11 |
| 2000-04-06 | vs LAN | 4 | W 11-3 | 2-2 | 3 | 9,121 | Carl Pavano | Carlos Perez | Carl Pavano | Carlos Perez | | 25 | 28 | -3 |
| 2000-04-07 | vs SDN | 5 | L 5-10 | 2-3 | 4 | 12,260 | Jeremy Powell | Brian Meadows | Brian Meadows | Jeremy Powell | | 30 | 38 | -8 |
| 2000-04-08 | vs SDN | 6 | W 10-9 | 3-3 | 3 | 13,528 | Dustin Hermanson | Sterling Hitchcock | Anthony Telford | Donne Wall | Ugueth Urbina | 40 | 47 | -7 |
| 2000-04-09 | vs SDN | 7 | W 2-1 | 4-3 | 3 | 9,782 | Hideki Irabu | Brian Boehringer | Hideki Irabu | Brian Boehringer | Ugueth Urbina | 42 | 48 | -6 |
| 2000-04-11 | @ PIT | 8 | W 7-3 | 5-3 | 1 | 11,335 | Javier Vazquez | Kris Benson | Javier Vazquez | Kris Benson | Steve Kline | 49 | 51 | -2 |
| 2000-04-12 | @ PIT | 9 | L 4-6 | 5-4 | 2 | 10,290 | Carl Pavano | Francisco Cordova | Jose Silva | Miguel Batista | Mike Williams | 53 | 57 | -4 |
| 2000-04-13 | @ PIT | 10 | L 3-4 | 5-5 | 2 | 11,162 | Jeremy Powell | Todd Ritchie | Jose Silva | Ugueth Urbina | | 56 | 61 | -5 |
| 2000-04-14 | @ PHI | 11 | W 4-0 | 6-5 | 2 | 12,366 | Dustin Hermanson | Chris Brock | Dustin Hermanson | Chris Brock | | 60 | 61 | -1 |
| 2000-04-16 | @ PHI | 12 | L 4-5 | 6-6 | 3 | 18,648 | Hideki Irabu | Andy Ashby | Scott Aldred | Anthony Telford | | 64 | 66 | -2 |
| 2000-04-18 | vs CHN | 13 | W 4-3 | 7-6 | 3 | 9,975 | Javier Vazquez | Kevin Tapani | Scott Strickland | Kevin Tapani | Ugueth Urbina | 68 | 69 | -1 |
| 2000-04-19 | vs CHN | 14 | W 7-3 | 8-6 | 2 | 10,112 | Carl Pavano | Andrew Lorraine | Carl Pavano | Ruben Quevedo | | 75 | 72 | 3 |
| 2000-04-20 | vs CHN | 15 | L 6-10 | 8-7 | 4 | 12,186 | Jeremy Powell | Scott Downs | Brian Williams | Matt Blank | | 81 | 82 | -1 |
| 2000-04-21 | vs MIL | 16 | W 5-1 | 9-7 | 2 | 12,315 | Dustin Hermanson | Jimmy Haynes | Dustin Hermanson | Jimmy Haynes | Ugueth Urbina | 86 | 83 | 3 |
| 2000-04-22 | vs MIL | 17 | L 3-7 | 9-8 | 4 | 14,461 | Hideki Irabu | Everett Stull | Everett Stull | Hideki Irabu | | 89 | 90 | -1 |
| 2000-04-23 | vs MIL | 18 | W 6-4 | 10-8 | 4 | 14,410 | Javier Vazquez | Jaime Navarro | Javier Vazquez | Jaime Navarro | Ugueth Urbina | 95 | 94 | 1 |
| 2000-04-25 | vs COL | 19 | W 10-4 | 11-8 | 4 | 10,019 | Carl Pavano | Brian Bohanon | Carl Pavano | Brian Bohanon | | 105 | 98 | 7 |
| 2000-04-26 | vs COL | 20 | W 9-2 | 12-8 | 3 | 10,735 | Dustin Hermanson | Kevin Jarvis | Dustin Hermanson | Kevin Jarvis | Ugueth Urbina | 114 | 100 | 14 |
| 2000-04-28 | @ SFN | 21 | W 9-3 | 13-8 | 2 | 40,930 | Hideki Irabu | Russ Ortiz | Anthony Telford | Russ Ortiz | | 123 | 103 | 20 |
| 2000-04-29 | @ SFN | 22 | L 1-2 | 13-9 | 3 | 40,930 | Javier Vazquez | Kirk Rueter | John Johnstone | Anthony Telford | Robb Nen | 124 | 105 | 19 |
| 2000-04-30 | @ SFN | 23 | W 4-3 | 14-9 | 3 | 40,930 | Carl Pavano | Joe Nathan | Scott Strickland | John Johnstone | Ugueth Urbina | 128 | 108 | 20 |
| 2000-05-01 | @ COL | 24 | L 8-15 | 14-10 | 3 | 35,104 | Dustin Hermanson | Kevin Jarvis | Gabe White | Dustin Hermanson | | 136 | 123 | 13 |
| 2000-05-02 | @ COL | 25 | L 6-12 | 14-11 | 3 | 39,132 | Jeremy Powell | Scott Karl | Scott Karl | Jeremy Powell | | 142 | 135 | 7 |
| 2000-05-03 | @ COL | 26 | L 7-16 | 14-12 | 3 | 40,096 | Hideki Irabu | Pedro Astacio | Pedro Astacio | Hideki Irabu | | 149 | 151 | -2 |
| 2000-05-05 | @ MIL | 27 | W 10-2 | 15-12 | 2 | 10,002 | Javier Vazquez | Jason Bere | Javier Vazquez | Jason Bere | | 159 | 153 | 6 |
| 2000-05-06 | @ MIL | 28 | W 3-2 | 16-12 | 2 | 12,381 | Carl Pavano | Steve Woodard | Anthony Telford | David Weathers | Ugueth Urbina | 162 | 155 | 7 |
| 2000-05-07 | @ MIL | 29 | L 4-9 | 16-13 | 2 | 11,989 | Dustin Hermanson | Jimmy Haynes | Jimmy Haynes | Dustin Hermanson | | 166 | 164 | 2 |
| 2000-05-09 | vs PHI | 30 | W 3-2 | 17-13 | 2 | 8,845 | Hideki Irabu | Chris Brock | Steve Kline | Wayne Gomes | | 169 | 166 | 3 |
| 2000-05-10 | vs PHI | 31 | L 0-8 | 17-14 | 2 | 9,411 | Javier Vazquez | Robert Person | Robert Person | Javier Vazquez | | 169 | 174 | -5 |
| 2000-05-11 | vs PHI | 32 | L 4-6 | 17-15 | 2 | 8,311 | Carl Pavano | Randy Wolf | Randy Wolf | Carl Pavano | Wayne Gomes | 173 | 180 | -7 |
| 2000-05-12 | vs CHN | 33 | W 8-3 | 18-15 | 2 | 15,626 | Mike Thurman | Kerry Wood | Mike Thurman | Kerry Wood | Dustin Hermanson | 181 | 183 | -2 |
| 2000-05-13 | vs CHN | 34 | L 1-2 | 18-16 | 3 | 14,321 | Tony Armas | Jon Lieber | Jon Lieber | Tony Armas | | 182 | 185 | -3 |
| 2000-05-14 | vs CHN | 35 | W 16-15 | 19-16 | 2 | 10,621 | Hideki Irabu | Ismael Valdez | Dustin Hermanson | Rick Aguilera | | 198 | 200 | -2 |
| 2000-05-16 | vs ARI | 36 | W 2-0 | 20-16 | 2 | 11,898 | Javier Vazquez | Randy Johnson | Javier Vazquez | Randy Johnson | Dustin Hermanson | 200 | 200 | 0 |
| 2000-05-17 | vs ARI | 37 | W 10-2 | 21-16 | 2 | 8,766 | Carl Pavano | Armando Reynoso | Carl Pavano | Armando Reynoso | | 210 | 202 | 8 |
| 2000-05-18 | vs ARI | 38 | L 6-8 | 21-17 | 2 | 11,073 | Mike Thurman | Brian Anderson | Byung-Hyun Kim | Anthony Telford | | 216 | 210 | 6 |
| 2000-05-19 | vs HOU | 39 | W 3-2 | 22-17 | 2 | 12,679 | Tony Armas | Octavio Dotel | Dustin Hermanson | Joe Slusarski | | 219 | 212 | 7 |
| 2000-05-20 | vs HOU | 40 | W 8-7 | 23-17 | 2 | 15,166 | Hideki Irabu | Scott Elarton | Hideki Irabu | Scott Elarton | Dustin Hermanson | 227 | 219 | 8 |
| 2000-05-21 | vs HOU | 41 | W 8-3 | 24-17 | 2 | 20,111 | Javier Vazquez | Jose Lima | Javier Vazquez | Jose Lima | | 235 | 222 | 13 |
| 2000-05-23 | @ SFN | 42 | W 3-2 | 25-17 | 2 | 40,930 | Carl Pavano | Kirk Rueter | Carl Pavano | Kirk Rueter | Dustin Hermanson | 238 | 224 | 14 |
| 2000-05-24 | @ SFN | 43 | L 0-18 | 25-18 | 2 | 40,930 | Mike Thurman | Shawn Estes | Shawn Estes | Mike Thurman | | 238 | 242 | -4 |
| 2000-05-25 | @ SFN | 44 | L 1-4 | 25-19 | 2 | 40,930 | Tony Armas | Livan Hernandez | Livan Hernandez | Tony Armas | Robb Nen | 239 | 246 | -7 |
| 2000-05-26 | @ SDN | 45 | L 2-6 | 25-20 | 2 | 19,517 | Hideki Irabu | Sterling Hitchcock | Matt Whiteside | Hideki Irabu | | 241 | 252 | -11 |
| 2000-05-27 | @ SDN | 46 | L 2-4 | 25-21 | 3 | 40,110 | Javier Vazquez | Matt Clement | Donne Wall | Steve Kline | Trevor Hoffman | 243 | 256 | -13 |
| 2000-05-28 | @ SDN | 47 | L 3-4 | 25-22 | 3 | 26,411 | Carl Pavano | Stan Spencer | Kevin Walker | Carl Pavano | Trevor Hoffman | 246 | 260 | -14 |
| 2000-05-30 | @ CIN | 48 | L 2-4 | 25-23 | 3 | 20,250 | Tony Armas | Osvaldo Fernandez | Osvaldo Fernandez | Tony Armas | Scott Williamson | 248 | 264 | -16 |
| 2000-05-31 | @ CIN | 49 | W 10-4 | 26-23 | 3 | 21,207 | Mike Johnson | Steve Parris | Mike Johnson | Steve Parris | | 258 | 268 | -10 |
| 2000-06-01 | @ CIN | 50 | W 9-7 | 27-23 | 3 | 23,099 | Javier Vazquez | Ron Villone | Javier Vazquez | Ron Villone | Steve Kline | 267 | 275 | -8 |
| 2000-06-02 | vs BAL | 51 | W 5-3 | 28-23 | 3 | 12,654 | Carl Pavano | Jason Johnson | Carl Pavano | Jason Johnson | Steve Kline | 272 | 278 | -6 |
| 2000-06-03 | vs BAL | 52 | W 7-4 | 29-23 | 3 | 13,628 | T.J. Tucker | Pat Rapp | Felipe Lira | Pat Rapp | Steve Kline | 279 | 282 | -3 |
| 2000-06-04 | vs BAL | 53 | W 1-0 | 30-23 | 2 | 15,181 | Tony Armas | Sidney Ponson | Tony Armas | Sidney Ponson | Steve Kline | 280 | 282 | -2 |
| 2000-06-05 | vs NYA | 54 | W 6-4 | 31-23 | 2 | 18,095 | Dustin Hermanson | David Cone | Mike Johnson | David Cone | Steve Kline | 286 | 286 | 0 |
| 2000-06-06 | vs NYA | 55 | L 1-8 | 31-24 | 2 | 24,453 | Javier Vazquez | Jason Grimsley | Jason Grimsley | Javier Vazquez | | 287 | 294 | -7 |
| 2000-06-07 | vs NYA | 56 | L 2-7 | 31-25 | 2 | 25,381 | Carl Pavano | Orlando Hernandez | Orlando Hernandez | Carl Pavano | | 289 | 301 | -12 |
| 2000-06-09 | @ TOR | 57 | L 3-13 | 31-26 | 3 | 26,122 | T.J. Tucker | Chris Carpenter | Chris Carpenter | T.J. Tucker | | 292 | 314 | -22 |
| 2000-06-10 | @ TOR | 58 | W 11-2 | 32-26 | 3 | 30,239 | Tony Armas | Kelvim Escobar | Tony Armas | Kelvim Escobar | | 303 | 316 | -13 |
| 2000-06-11 | @ TOR | 59 | L 3-8 | 32-27 | 3 | 25,838 | Dustin Hermanson | David Wells | Billy Koch | Guillermo Mota | | 306 | 324 | -18 |
| 2000-06-12 | @ MIL | 60 | L 1-8 | 32-28 | 3 | 16,686 | Javier Vazquez | Jason Bere | Jason Bere | Javier Vazquez | | 307 | 332 | -25 |
| 2000-06-13 | @ MIL | 61 | W 9-4 | 33-28 | 3 | 10,705 | Carl Pavano | Steve Woodard | Carl Pavano | Steve Woodard | | 316 | 336 | -20 |
| 2000-06-14 | @ MIL | 62 | L 2-11 | 33-29 | 3 | 12,875 | Mike Johnson | Jamey Wright | Jamey Wright | Mike Johnson | | 318 | 347 | -29 |
| 2000-06-16 | @ CHN | 63 | L 8-9 | 33-30 | 3 | 38,010 | Tony Armas | Kerry Wood | Todd Van Poppel | Tony Armas | Rick Aguilera | 326 | 356 | -30 |
| 2000-06-17 | @ CHN | 64 | L 0-1 | 33-31 | 3 | 39,502 | Dustin Hermanson | Ismael Valdez | Steve Rain | Dustin Hermanson | Rick Aguilera | 326 | 357 | -31 |
| 2000-06-18 | @ CHN | 65 | W 4-3 | 34-31 | 3 | 38,752 | Javier Vazquez | Jon Lieber | Anthony Telford | Daniel Garibay | Brad Rigby | 330 | 360 | -30 |
| 2000-06-19 | vs PIT | 66 | W 2-1 | 35-31 | 3 | 7,483 | Carl Pavano | Jose Silva | Carl Pavano | Rich Loiselle | Steve Kline | 332 | 361 | -29 |
| 2000-06-20 | vs PIT | 67 | L 1-2 | 35-32 | 3 | 8,056 | Mike Johnson | Kris Benson | Kris Benson | Mike Johnson | Mike Williams | 333 | 363 | -30 |
| 2000-06-21 | vs PIT | 68 | L 3-8 | 35-33 | 3 | 8,324 | Tony Armas | Francisco Cordova | Francisco Cordova | Tony Armas | Chris Peters | 336 | 371 | -35 |
| 2000-06-22 | vs PIT | 69 | W 6-5 | 36-33 | 3 | 8,635 | Dustin Hermanson | Todd Ritchie | Dustin Hermanson | Todd Ritchie | Anthony Telford | 342 | 376 | -34 |
| 2000-06-23 | vs PHI | 70 | L 6-13 | 36-34 | 3 | 8,197 | Javier Vazquez | Dave Coggin | Dave Coggin | Javier Vazquez | | 348 | 389 | -41 |
| 2000-06-24 | vs PHI | 71 | L 1-8 | 36-35 | 3 | 8,374 | Carl Pavano | Randy Wolf | Randy Wolf | Carl Pavano | | 349 | 397 | -48 |
| 2000-06-25 | vs PHI | 72 | W 3-1 | 37-35 | 3 | 13,164 | Mike Johnson | Paul Byrd | Mike Johnson | Paul Byrd | Steve Kline | 352 | 398 | -46 |
| 2000-06-27 | vs ATL | 73 | W 6-4 | 38-35 | 3 | 11,636 | Tony Armas | Tom Glavine | Tony Armas | Tom Glavine | Steve Kline | 358 | 402 | -44 |
| 2000-06-28 | vs ATL | 74 | L 4-7 | 38-36 | 3 | 12,653 | Dustin Hermanson | Terry Mulholland | Terry Mulholland | Dustin Hermanson | Kerry Ligtenberg | 362 | 409 | -47 |
| 2000-06-30 | vs FLO | 75 | L 4-5 | 38-37 | 3 | 8,047 | Javier Vazquez | Chuck Smith | Armando Almanza | Steve Kline | Antonio Alfonseca | 366 | 414 | -48 |
| 2000-07-01 | vs FLO | 76 | L 5-6 | 38-38 | 3 | 8,529 | Mike Johnson | Ryan Dempster | Ryan Dempster | Mike Johnson | Antonio Alfonseca | 371 | 420 | -49 |
| 2000-07-02 | vs FLO | 77 | L 1-2 | 38-39 | 4 | 9,076 | Julio Santana | Reid Cornelius | Reid Cornelius | Julio Santana | Antonio Alfonseca | 372 | 422 | -50 |
| 2000-07-03 | @ ATL | 78 | W 17-1 | 39-39 | 4 | 44,302 | Tony Armas | Terry Mulholland | Tony Armas | Terry Mulholland | | 389 | 423 | -34 |
| 2000-07-04 | @ ATL | 79 | L 3-7 | 39-40 | 4 | 47,277 | Dustin Hermanson | Greg Maddux | Greg Maddux | Dustin Hermanson | | 392 | 430 | -38 |
| 2000-07-05 | @ ATL | 80 | W 6-5 | 40-40 | 4 | 34,044 | Javier Vazquez | Kevin Millwood | Javier Vazquez | Kevin Millwood | Steve Kline | 398 | 435 | -37 |
| 2000-07-06 | @ ATL | 81 | W 4-2 | 41-40 | 3 | 36,377 | Mike Johnson | John Burkett | Mike Johnson | John Burkett | Steve Kline | 402 | 437 | -35 |
| 2000-07-07 | vs TOR | 82 | W 10-5 | 42-40 | 3 | 13,317 | Julio Santana | Kelvim Escobar | Felipe Lira | Paul Quantrill | | 412 | 442 | -30 |
| 2000-07-08 | vs TOR | 83 | L 3-6 | 42-41 | 3 | 17,420 | Tony Armas | David Wells | David Wells | Tony Armas | Billy Koch | 415 | 448 | -33 |
| 2000-07-09 | vs TOR | 84 | L 3-13 | 42-42 | 4 | 22,489 | Dustin Hermanson | Frank Castillo | Frank Castillo | Dustin Hermanson | | 418 | 461 | -43 |
| 2000-07-13 | @ TBA | 85 | L 4-6 | 42-43 | 4 | 14,924 | Javier Vazquez | Bryan Rekar | Jim Mecir | Felipe Lira | Roberto Hernandez | 422 | 467 | -45 |
| 2000-07-14 | @ TBA | 86 | L 5-8 | 42-44 | 4 | 15,870 | Tony Armas | Albie Lopez | Albie Lopez | Tony Armas | Roberto Hernandez | 427 | 475 | -48 |
| 2000-07-15 | @ TBA | 87 | W 4-1 | 43-44 | 4 | 19,366 | Dustin Hermanson | Steve Trachsel | Dustin Hermanson | Steve Trachsel | Steve Kline | 431 | 476 | -45 |
| 2000-07-16 | @ BOS | 88 | L 2-5 | 43-45 | 4 | 32,164 | Mike Johnson | Tim Wakefield | Tim Wakefield | Mike Johnson | John Wasdin | 433 | 481 | -48 |
| 2000-07-17 | @ BOS | 89 | L 3-7 | 43-46 | 4 | 32,703 | Julio Santana | Jeff Fassero | Hipolito Pichardo | Anthony Telford | | 436 | 488 | -52 |
| 2000-07-18 | @ BOS | 90 | L 1-3 | 43-47 | 4 | 32,629 | Javier Vazquez | Pedro Martinez | Pedro Martinez | Javier Vazquez | Derek Lowe | 437 | 491 | -54 |
| 2000-07-19 | vs NYN | 91 | L 3-5 | 43-48 | 4 | 14,198 | Felipe Lira | Glendon Rusch | Pat Mahomes | Steve Kline | Armando Benitez | 440 | 496 | -56 |
| 2000-07-20 | vs NYN | 92 | W 4-1 | 44-48 | 4 | 13,641 | Dustin Hermanson | Mike Hampton | Dustin Hermanson | Mike Hampton | Scott Strickland | 444 | 497 | -53 |
| 2000-07-21 | @ FLO | 93 | W 7-3 | 45-48 | 4 | 11,234 | Mike Thurman | Chuck Smith | Mike Thurman | Chuck Smith | | 451 | 500 | -49 |
| 2000-07-22 | @ FLO | 94 | W 17-7 | 46-48 | 4 | 15,476 | Mike Johnson | Reid Cornelius | Mike Johnson | Reid Cornelius | | 468 | 507 | -39 |
| 2000-07-23 | @ FLO | 95 | W 7-6 | 47-48 | 3 | 11,307 | Javier Vazquez | Jesus Sanchez | Javier Vazquez | Jesus Sanchez | Scott Strickland | 475 | 513 | -38 |
| 2000-07-25 | @ NYN | 96 | L 0-5 | 47-49 | 3 | 41,028 | Dustin Hermanson | Glendon Rusch | Glendon Rusch | Dustin Hermanson | | 475 | 518 | -43 |
| 2000-07-27 | @ NYN | 97 | L 8-9 | 47-51 | 4 | 0 | Mike Thurman | Grant Roberts | John Franco | Scott Strickland | Armando Benitez | 483 | 527 | -44 |
| 2000-07-27 | @ NYN | 98 | L 3-4 | 47-51 | 4 | 35,088 | Hideki Irabu | Mike Hampton | Mike Hampton | Hideki Irabu | | 486 | 531 | -45 |
| 2000-07-28 | vs CIN | 99 | L 3-8 | 47-52 | 4 | 11,547 | Mike Johnson | Elmer Dessens | Elmer Dessens | Mike Johnson | | 489 | 539 | -50 |
| 2000-07-29 | vs CIN | 100 | L 3-4 | 47-53 | 4 | 13,577 | Javier Vazquez | Pete Harnisch | Danny Graves | Julio Santana | | 492 | 543 | -51 |
| 2000-07-30 | vs CIN | 101 | L 4-7 | 47-54 | 4 | 14,495 | Dustin Hermanson | Rob Bell | Rob Bell | Dustin Hermanson | Danny Graves | 496 | 550 | -54 |
| 2000-07-31 | vs SLN | 102 | L 0-4 | 47-55 | 4 | 9,558 | Mike Thurman | Darryl Kile | Darryl Kile | Mike Thurman | | 496 | 554 | -58 |
| 2000-08-01 | vs SLN | 103 | W 4-0 | 48-55 | 4 | 9,818 | Trey Moore | Rick Ankiel | Trey Moore | Rick Ankiel | | 500 | 554 | -54 |
| 2000-08-02 | vs SLN | 104 | L 7-10 | 48-56 | 4 | 9,669 | Mike Johnson | Pat Hentgen | Pat Hentgen | Mike Johnson | | 507 | 564 | -57 |
| 2000-08-04 | @ HOU | 105 | L 6-7 | 48-57 | 4 | 38,502 | Javier Vazquez | Chris Holt | Jason Green | Steve Kline | Octavio Dotel | 513 | 571 | -58 |
| 2000-08-05 | @ HOU | 106 | W 10-9 | 49-57 | 4 | 42,399 | Dustin Hermanson | Jose Lima | Scott Strickland | Marc Valdes | Steve Kline | 523 | 580 | -57 |
| 2000-08-06 | @ HOU | 107 | L 1-8 | 49-58 | 4 | 36,882 | Mike Thurman | Scott Elarton | Scott Elarton | Mike Thurman | | 524 | 588 | -64 |
| 2000-08-07 | @ ARI | 108 | L 2-5 | 49-59 | 4 | 31,526 | Trey Moore | Curt Schilling | Curt Schilling | Trey Moore | | 526 | 593 | -67 |
| 2000-08-08 | @ ARI | 109 | W 9-3 | 50-59 | 4 | 33,113 | Scott Downs | Brian Anderson | Felipe Lira | Brian Anderson | | 535 | 596 | -61 |
| 2000-08-09 | @ ARI | 110 | W 4-3 | 51-59 | 4 | 33,500 | Javier Vazquez | Randy Johnson | Scott Strickland | Geraldo Guzman | Anthony Telford | 539 | 599 | -60 |
| 2000-08-11 | vs COL | 111 | L 3-10 | 51-60 | 4 | 9,136 | Dustin Hermanson | Brian Bohanon | Brian Bohanon | Dustin Hermanson | | 542 | 609 | -67 |
| 2000-08-12 | vs COL | 112 | L 2-14 | 51-61 | 4 | 9,815 | Trey Moore | Masato Yoshii | Masato Yoshii | Trey Moore | | 544 | 623 | -79 |
| 2000-08-13 | vs COL | 113 | L 3-5 | 51-62 | 4 | 10,606 | Mike Thurman | Brian Rose | Bobby Chouinard | Scott Strickland | Gabe White | 547 | 628 | -81 |
| 2000-08-14 | vs COL | 114 | L 3-4 | 51-63 | 4 | 6,924 | Javier Vazquez | Julian Tavarez | Craig House | Scott Strickland | Jose Jimenez | 550 | 632 | -82 |
| 2000-08-15 | vs SFN | 115 | L 7-9 | 51-64 | 4 | 7,165 | Mike Johnson | Kirk Rueter | Miguel Del Toro | Felipe Lira | Robb Nen | 557 | 641 | -84 |
| 2000-08-16 | vs SFN | 116 | L 1-4 | 51-65 | 4 | 7,910 | Dustin Hermanson | Mark Gardner | Mark Gardner | Dustin Hermanson | Robb Nen | 558 | 645 | -87 |
| 2000-08-17 | vs SFN | 117 | L 4-5 | 51-66 | 4 | 9,198 | Trey Moore | Shawn Estes | Shawn Estes | Trey Moore | Felix Rodriguez | 562 | 650 | -88 |
| 2000-08-18 | @ SDN | 118 | W 6-3 | 52-66 | 4 | 20,597 | Mike Thurman | Matt Clement | Mike Thurman | Matt Clement | Scott Strickland | 568 | 653 | -85 |
| 2000-08-19 | @ SDN | 119 | L 3-4 | 52-67 | 4 | 56,779 | Javier Vazquez | Brian Tollberg | Kevin Walker | Julio Santana | | 571 | 657 | -86 |
| 2000-08-20 | @ SDN | 120 | L 4-5 | 52-68 | 4 | 25,343 | Felipe Lira | Jay Witasick | Jay Witasick | Felipe Lira | Trevor Hoffman | 575 | 662 | -87 |
| 2000-08-21 | @ LAN | 121 | W 4-1 | 53-68 | 4 | 32,053 | Dustin Hermanson | Matt Herges | Dustin Hermanson | Matt Herges | Scott Strickland | 579 | 663 | -84 |
| 2000-08-22 | @ LAN | 122 | L 6-14 | 53-69 | 4 | 29,804 | Trey Moore | Ismael Valdez | Terry Adams | Julio Santana | | 585 | 677 | -92 |
| 2000-08-23 | @ LAN | 123 | L 1-5 | 53-70 | 4 | 31,337 | Mike Thurman | Kevin Brown | Kevin Brown | Mike Thurman | | 586 | 682 | -96 |
| 2000-08-24 | @ LAN | 124 | L 0-7 | 53-71 | 4 | 28,896 | Javier Vazquez | Chan Ho Park | Chan Ho Park | Javier Vazquez | | 586 | 689 | -103 |
| 2000-08-25 | vs HOU | 125 | L 1-3 | 53-72 | 4 | 7,636 | Felipe Lira | Chris Holt | Chris Holt | Felipe Lira | Octavio Dotel | 587 | 692 | -105 |
| 2000-08-26 | vs HOU | 126 | W 5-4 | 54-72 | 4 | 8,619 | Dustin Hermanson | Jose Lima | Dustin Hermanson | Jose Lima | Steve Kline | 592 | 696 | -104 |
| 2000-08-27 | vs HOU | 127 | L 3-7 | 54-73 | 5 | 10,732 | Trey Moore | Scott Elarton | Scott Elarton | Trey Moore | | 595 | 703 | -108 |
| 2000-08-28 | vs ARI | 128 | W 9-5 | 55-73 | 5 | 6,389 | Mike Thurman | Curt Schilling | Mike Thurman | Curt Schilling | Anthony Telford | 604 | 708 | -104 |
| 2000-08-29 | vs ARI | 129 | L 7-8 | 55-74 | 5 | 6,029 | Javier Vazquez | Geraldo Guzman | Dan Plesac | Scott Forster | Matt Mantei | 611 | 716 | -105 |
| 2000-08-30 | vs ARI | 130 | L 0-7 | 55-75 | 5 | 7,650 | Felipe Lira | Randy Johnson | Randy Johnson | Felipe Lira | | 611 | 723 | -112 |
| 2000-09-01 | @ CIN | 131 | L 2-8 | 55-76 | 5 | 22,973 | Dustin Hermanson | Rob Bell | Rob Bell | Dustin Hermanson | | 613 | 731 | -118 |
| 2000-09-02 | @ CIN | 132 | W 9-5 | 56-76 | 4 | 29,403 | Trey Moore | Ron Villone | Felipe Lira | Ron Villone | | 622 | 736 | -114 |
| 2000-09-03 | @ CIN | 133 | L 1-8 | 56-77 | 4 | 26,152 | Mike Thurman | Steve Parris | Steve Parris | Mike Thurman | | 623 | 744 | -121 |
| 2000-09-04 | @ SLN | 134 | L 2-4 | 56-78 | 4 | 39,704 | Javier Vazquez | Pat Hentgen | Pat Hentgen | Javier Vazquez | Dave Veres | 625 | 748 | -123 |
| 2000-09-05 | @ SLN | 135 | L 6-7 | 56-79 | 4 | 31,821 | Julio Santana | Britt Reames | Britt Reames | Julio Santana | Mike Timlin | 631 | 755 | -124 |
| 2000-09-06 | @ SLN | 136 | W 7-2 | 57-79 | 4 | 30,280 | Dustin Hermanson | Garrett Stephenson | Dustin Hermanson | Garrett Stephenson | | 638 | 757 | -119 |
| 2000-09-07 | @ SLN | 137 | L 1-6 | 57-80 | 4 | 30,799 | Tony Armas | Darryl Kile | Darryl Kile | Tony Armas | | 639 | 763 | -124 |
| 2000-09-08 | @ ATL | 138 | L 2-3 | 57-81 | 4 | 35,870 | Trey Moore | Andy Ashby | Andy Ashby | Trey Moore | John Rocker | 641 | 766 | -125 |
| 2000-09-09 | @ ATL | 139 | W 7-5 | 58-81 | 4 | 47,775 | Mike Thurman | John Burkett | Julio Santana | Chris Seelbach | | 648 | 771 | -123 |
| 2000-09-10 | @ ATL | 140 | W 4-0 | 59-81 | 4 | 39,068 | Javier Vazquez | Tom Glavine | Javier Vazquez | Tom Glavine | | 652 | 771 | -119 |
| 2000-09-11 | @ PHI | 141 | L 2-5 | 60-82 | 4 | 0 | Dustin Hermanson | Cliff Politte | Cliff Politte | Dustin Hermanson | Jeff Brantley | 654 | 776 | -122 |
| 2000-09-11 | @ PHI | 142 | W 7-6 | 60-82 | 4 | 11,310 | Mike Johnson | Randy Wolf | Guillermo Mota | Vicente Padilla | Scott Strickland | 661 | 782 | -121 |
| 2000-09-12 | @ PHI | 143 | W 1-0 | 61-82 | 4 | 12,135 | Tony Armas | Amaury Telemaco | Tony Armas | Amaury Telemaco | Scott Strickland | 662 | 782 | -120 |
| 2000-09-13 | @ PHI | 144 | L 5-15 | 61-83 | 4 | 12,316 | Felipe Lira | Bruce Chen | Bruce Chen | Felipe Lira | | 667 | 797 | -130 |
| 2000-09-14 | vs NYN | 145 | L 4-10 | 61-84 | 4 | 6,219 | Mike Thurman | Glendon Rusch | Glendon Rusch | Mike Thurman | | 671 | 807 | -136 |
| 2000-09-15 | vs NYN | 146 | W 4-3 | 62-84 | 4 | 6,979 | Javier Vazquez | Al Leiter | Javier Vazquez | Turk Wendell | Scott Strickland | 675 | 810 | -135 |
| 2000-09-16 | vs NYN | 147 | L 4-10 | 62-85 | 4 | 9,045 | Dustin Hermanson | Rick Reed | Rick Reed | Dustin Hermanson | | 679 | 820 | -141 |
| 2000-09-17 | vs NYN | 148 | W 5-0 | 63-85 | 4 | 9,349 | Tony Armas | Robert Joseph Jones | Tony Armas | Robert Joseph Jones | | 684 | 820 | -136 |
| 2000-09-18 | vs FLO | 149 | W 11-4 | 64-85 | 4 | 4,769 | Mike Johnson | Jesus Sanchez | Felipe Lira | Jesus Sanchez | | 695 | 824 | -129 |
| 2000-09-19 | vs FLO | 150 | L 1-3 | 64-86 | 4 | 5,283 | Mike Thurman | Ryan Dempster | Ryan Dempster | Mike Thurman | Antonio Alfonseca | 696 | 827 | -131 |
| 2000-09-20 | vs FLO | 151 | W 4-2 | 65-86 | 4 | 5,851 | Javier Vazquez | Reid Cornelius | Javier Vazquez | Reid Cornelius | Scott Strickland | 700 | 829 | -129 |
| 2000-09-21 | vs FLO | 152 | W 10-3 | 66-86 | 4 | 4,801 | Dustin Hermanson | A.J. Burnett | Dustin Hermanson | A.J. Burnett | | 710 | 832 | -122 |
| 2000-09-22 | vs ATL | 153 | W 6-4 | 67-86 | 4 | 8,464 | Tony Armas | Kevin Millwood | Tony Armas | Kevin Millwood | Scott Strickland | 716 | 836 | -120 |
| 2000-09-23 | vs ATL | 154 | L 0-10 | 67-87 | 4 | 10,136 | Felipe Lira | Greg Maddux | Greg Maddux | Felipe Lira | | 716 | 846 | -130 |
| 2000-09-24 | vs ATL | 155 | L 5-14 | 67-88 | 4 | 11,350 | Mike Thurman | Andy Ashby | Andy Ashby | Mike Thurman | | 721 | 860 | -139 |
| 2000-09-25 | vs ATL | 156 | L 0-6 | 67-89 | 4 | 6,931 | Javier Vazquez | Tom Glavine | Tom Glavine | Javier Vazquez | | 721 | 866 | -145 |
| 2000-09-26 | @ FLO | 157 | L 4-5 | 67-90 | 4 | 8,538 | Dustin Hermanson | Ryan Dempster | Antonio Alfonseca | Steve Kline | | 725 | 871 | -146 |
| 2000-09-27 | @ FLO | 158 | L 3-6 | 67-91 | 4 | 10,269 | Tony Armas | A.J. Burnett | A.J. Burnett | Tony Armas | Antonio Alfonseca | 728 | 877 | -149 |
| 2000-09-28 | @ FLO | 159 | L 4-7 | 67-92 | 4 | 7,864 | Felipe Lira | Brad Penny | Brad Penny | Felipe Lira | Antonio Alfonseca | 732 | 884 | -152 |
| 2000-09-29 | @ NYN | 160 | L 2-11 | 67-93 | 4 | 28,788 | Mike Thurman | Mike Hampton | Mike Hampton | Mike Thurman | | 734 | 895 | -161 |
| 2000-09-30 | @ NYN | 161 | L 2-4 | 67-94 | 4 | 39,468 | Javier Vazquez | Glendon Rusch | Turk Wendell | Javier Vazquez | Armando Benitez | 736 | 899 | -163 |
| 2000-10-01 | @ NYN | 162 | L 2-3 | 67-95 | 4 | 44,869 | Dustin Hermanson | Rick Reed | Pat Mahomes | Jeremy Powell | | 738 | 902 | -164 |