| 2000-04-03 | @ MON | 1 | W 10-4 | 1-0 | 1 | 51,249 | Kevin Brown | Dustin Hermanson | Kevin Brown | Dustin Hermanson | Terry Adams | 10 | 4 | 6 |
| 2000-04-04 | @ MON | 2 | W 10-4 | 2-0 | 2 | 12,143 | Chan Ho Park | Hideki Irabu | Chan Ho Park | Hideki Irabu | | 20 | 8 | 12 |
| 2000-04-05 | @ MON | 3 | L 5-6 | 2-1 | 2 | 8,867 | Orel Hershiser | Javier Vazquez | Anthony Telford | Jeff Shaw | | 25 | 14 | 11 |
| 2000-04-06 | @ MON | 4 | L 3-11 | 2-2 | 3 | 9,121 | Carlos Perez | Carl Pavano | Carl Pavano | Carlos Perez | | 28 | 25 | 3 |
| 2000-04-07 | @ NYN | 5 | L 1-2 | 2-3 | 4 | 27,791 | Darren Dreifort | Rick Reed | Rick Reed | Darren Dreifort | Armando Benitez | 29 | 27 | 2 |
| 2000-04-08 | @ NYN | 6 | W 6-5 | 3-3 | 3 | 37,814 | Kevin Brown | Pat Mahomes | Mike Fetters | Armando Benitez | Jeff Shaw | 35 | 32 | 3 |
| 2000-04-11 | @ SFN | 7 | W 6-5 | 4-3 | 2 | 40,930 | Chan Ho Park | Kirk Rueter | Chan Ho Park | Kirk Rueter | Jeff Shaw | 41 | 37 | 4 |
| 2000-04-12 | @ SFN | 8 | W 6-5 | 5-3 | 2 | 40,390 | Darren Dreifort | Joe Nathan | Terry Adams | Ben Weber | Jeff Shaw | 47 | 42 | 5 |
| 2000-04-13 | @ SFN | 9 | W 11-7 | 6-3 | 2 | 40,930 | Carlos Perez | Mark Gardner | Carlos Perez | Mark Gardner | Jeff Shaw | 58 | 49 | 9 |
| 2000-04-14 | vs CIN | 10 | W 8-1 | 7-3 | 2 | 53,223 | Orel Hershiser | Rob Bell | Orel Hershiser | Rob Bell | | 66 | 50 | 16 |
| 2000-04-15 | vs CIN | 11 | L 4-5 | 7-4 | 2 | 51,179 | Eric Gagne | Denny Neagle | Scott Williamson | Alan Mills | Danny Graves | 70 | 55 | 15 |
| 2000-04-16 | vs CIN | 12 | L 3-5 | 7-5 | 2 | 52,594 | Chan Ho Park | Steve Parris | Steve Parris | Chan Ho Park | Danny Graves | 73 | 60 | 13 |
| 2000-04-18 | vs HOU | 13 | W 5-3 | 8-5 | 2 | 26,298 | Darren Dreifort | Octavio Dotel | Darren Dreifort | Octavio Dotel | Jeff Shaw | 78 | 63 | 15 |
| 2000-04-19 | vs HOU | 14 | L 3-10 | 8-6 | 2 | 29,717 | Orel Hershiser | Shane Reynolds | Shane Reynolds | Orel Hershiser | | 81 | 73 | 8 |
| 2000-04-21 | @ CIN | 15 | W 9-2 | 9-6 | 2 | 34,458 | Eric Gagne | Steve Parris | Matt Herges | Steve Parris | Terry Adams | 90 | 75 | 15 |
| 2000-04-22 | @ CIN | 16 | W 16-2 | 10-6 | 2 | 35,557 | Chan Ho Park | Pete Harnisch | Chan Ho Park | Pete Harnisch | Alan Mills | 106 | 77 | 29 |
| 2000-04-23 | @ CIN | 17 | W 11-3 | 11-6 | 1 | 29,124 | Carlos Perez | Ron Villone | Carlos Perez | Ron Villone | | 117 | 80 | 37 |
| 2000-04-24 | @ NYN | 18 | L 0-1 | 11-7 | 2 | 37,987 | Darren Dreifort | Pat Mahomes | Armando Benitez | Terry Adams | | 117 | 81 | 36 |
| 2000-04-25 | @ ATL | 19 | L 0-1 | 11-8 | 2 | 35,046 | Kevin Brown | Tom Glavine | Tom Glavine | Kevin Brown | | 117 | 82 | 35 |
| 2000-04-26 | @ ATL | 20 | L 1-5 | 11-9 | 2 | 31,734 | Eric Gagne | Kevin Millwood | Kevin Millwood | Eric Gagne | | 118 | 87 | 31 |
| 2000-04-27 | @ ATL | 21 | L 3-6 | 11-10 | 2 | 37,750 | Chan Ho Park | Terry Mulholland | Terry Mulholland | Chan Ho Park | John Rocker | 121 | 93 | 28 |
| 2000-04-28 | vs FLO | 22 | W 5-3 | 12-10 | 2 | 46,012 | Carlos Perez | Brad Penny | Terry Adams | Brad Penny | Jeff Shaw | 126 | 96 | 30 |
| 2000-04-29 | vs FLO | 23 | W 13-12 | 13-10 | 2 | 35,583 | Darren Dreifort | Jesus Sanchez | Jeff Shaw | Antonio Alfonseca | | 139 | 108 | 31 |
| 2000-04-30 | vs FLO | 24 | W 7-1 | 14-10 | 2 | 31,940 | Kevin Brown | Alex Fernandez | Kevin Brown | Alex Fernandez | | 146 | 109 | 37 |
| 2000-05-01 | vs ATL | 25 | L 1-2 | 14-11 | 2 | 28,790 | Eric Gagne | Kevin Millwood | Kevin Millwood | Eric Gagne | John Rocker | 147 | 111 | 36 |
| 2000-05-02 | vs ATL | 26 | L 3-5 | 14-12 | 2 | 30,246 | Chan Ho Park | Terry Mulholland | Bruce Chen | Terry Adams | John Rocker | 150 | 116 | 34 |
| 2000-05-03 | vs ATL | 27 | W 6-4 | 15-12 | 2 | 34,960 | Carlos Perez | Greg Maddux | Carlos Perez | Greg Maddux | Jeff Shaw | 156 | 120 | 36 |
| 2000-05-05 | vs HOU | 28 | W 3-2 | 16-12 | 2 | 45,428 | Kevin Brown | Shane Reynolds | Jeff Shaw | Doug Henry | | 159 | 122 | 37 |
| 2000-05-06 | vs HOU | 29 | W 9-6 | 17-12 | 2 | 44,345 | Darren Dreifort | Octavio Dotel | Darren Dreifort | Octavio Dotel | | 168 | 128 | 40 |
| 2000-05-07 | vs HOU | 30 | L 8-14 | 17-13 | 2 | 52,806 | Eric Gagne | Jose Lima | Billy Wagner | Jeff Shaw | | 176 | 142 | 34 |
| 2000-05-08 | @ ARI | 31 | L 7-15 | 17-14 | 3 | 33,338 | Chan Ho Park | Omar Daal | Omar Daal | Chan Ho Park | | 183 | 157 | 26 |
| 2000-05-09 | @ ARI | 32 | L 7-11 | 17-15 | 3 | 32,326 | Carlos Perez | Armando Reynoso | Vicente Padilla | Orel Hershiser | | 190 | 168 | 22 |
| 2000-05-10 | @ ARI | 33 | L 1-2 | 17-16 | 3 | 43,345 | Kevin Brown | Randy Johnson | Byung-Hyun Kim | Terry Adams | | 191 | 170 | 21 |
| 2000-05-12 | @ SLN | 34 | W 13-0 | 18-16 | 3 | 44,975 | Darren Dreifort | Darryl Kile | Darren Dreifort | Darryl Kile | | 204 | 170 | 34 |
| 2000-05-13 | @ SLN | 35 | W 3-1 | 19-16 | 2 | 48,372 | Chan Ho Park | Rick Ankiel | Chan Ho Park | Dave Veres | Jeff Shaw | 207 | 171 | 36 |
| 2000-05-14 | @ SLN | 36 | L 10-12 | 19-17 | 2 | 45,151 | Carlos Perez | Pat Hentgen | Heathcliff Slocumb | Carlos Perez | Dave Veres | 217 | 183 | 34 |
| 2000-05-16 | @ CHN | 37 | W 6-5 | 20-17 | 2 | 38,860 | Kevin Brown | Kevin Tapani | Alan Mills | Kevin Tapani | Jeff Shaw | 223 | 188 | 35 |
| 2000-05-17 | @ CHN | 38 | W 8-6 | 21-17 | 2 | 30,235 | Darren Dreifort | Scott Downs | Alan Mills | Felix Heredia | Jeff Shaw | 231 | 194 | 37 |
| 2000-05-19 | @ FLO | 39 | W 5-3 | 22-17 | 2 | 16,467 | Chan Ho Park | Vladimir Nunez | Matt Herges | Braden Looper | Jeff Shaw | 236 | 197 | 39 |
| 2000-05-20 | @ FLO | 40 | W 12-6 | 23-17 | 2 | 21,142 | Carlos Perez | Brad Penny | Carlos Perez | Brad Penny | | 248 | 203 | 45 |
| 2000-05-21 | @ FLO | 41 | W 12-3 | 24-17 | 2 | 15,538 | Kevin Brown | Jesus Sanchez | Kevin Brown | Jesus Sanchez | | 260 | 206 | 54 |
| 2000-05-22 | vs CIN | 42 | W 4-3 | 25-17 | 2 | 31,000 | Darren Dreifort | Denny Neagle | Matt Herges | Manny Aybar | | 264 | 209 | 55 |
| 2000-05-23 | vs CIN | 43 | L 1-3 | 25-18 | 2 | 39,411 | Eric Gagne | Osvaldo Fernandez | Osvaldo Fernandez | Eric Gagne | Danny Graves | 265 | 212 | 53 |
| 2000-05-24 | vs CIN | 44 | L 3-10 | 25-19 | 2 | 31,740 | Chan Ho Park | Steve Parris | Scott Sullivan | Chan Ho Park | | 268 | 222 | 46 |
| 2000-05-26 | vs PHI | 45 | W 11-4 | 26-19 | 2 | 37,048 | Kevin Brown | Paul Byrd | Kevin Brown | Paul Byrd | | 279 | 226 | 53 |
| 2000-05-27 | vs PHI | 46 | L 6-7 | 26-20 | 2 | 33,967 | Darren Dreifort | Robert Person | Robert Person | Darren Dreifort | Jeff Brantley | 285 | 233 | 52 |
| 2000-05-28 | vs PHI | 47 | L 2-4 | 26-21 | 2 | 28,603 | Carlos Perez | Randy Wolf | Randy Wolf | Antonio Osuna | | 287 | 237 | 50 |
| 2000-05-29 | vs NYN | 48 | W 4-1 | 27-21 | 2 | 43,084 | Chan Ho Park | Al Leiter | Chan Ho Park | Al Leiter | | 291 | 238 | 53 |
| 2000-05-30 | vs NYN | 49 | L 5-10 | 27-22 | 3 | 26,102 | Eric Gagne | Robert Joseph Jones | John Franco | Jeff Shaw | | 296 | 248 | 48 |
| 2000-05-31 | vs NYN | 50 | W 4-3 | 28-22 | 3 | 31,323 | Kevin Brown | Mike Hampton | Mike Fetters | Turk Wendell | | 300 | 251 | 49 |
| 2000-06-02 | @ ANA | 51 | L 5-12 | 28-23 | 3 | 43,619 | Darren Dreifort | Kent Bottenfield | Kent Bottenfield | Darren Dreifort | | 305 | 263 | 42 |
| 2000-06-03 | @ ANA | 52 | W 8-3 | 29-23 | 3 | 34,580 | Chan Ho Park | Brian Cooper | Chan Ho Park | Brian Cooper | | 313 | 266 | 47 |
| 2000-06-04 | @ ANA | 53 | L 7-8 | 29-24 | 3 | 40,489 | Carlos Perez | Jarrod Washburn | Troy Percival | Antonio Osuna | | 320 | 274 | 46 |
| 2000-06-05 | @ TEX | 54 | L 0-2 | 29-25 | 3 | 34,709 | Kevin Brown | Ryan Glynn | Ryan Glynn | Kevin Brown | John Wetteland | 320 | 276 | 44 |
| 2000-06-06 | @ TEX | 55 | W 7-1 | 30-25 | 3 | 35,847 | Eric Gagne | Mark Clark | Eric Gagne | Mark Clark | | 327 | 277 | 50 |
| 2000-06-07 | @ TEX | 56 | W 11-6 | 31-25 | 3 | 35,860 | Darren Dreifort | Rick Helling | Darren Dreifort | Rick Helling | | 338 | 283 | 55 |
| 2000-06-08 | vs HOU | 57 | W 5-2 | 32-25 | 2 | 23,648 | Chan Ho Park | Chris Holt | Chan Ho Park | Chris Holt | Mike Fetters | 343 | 285 | 58 |
| 2000-06-09 | vs OAK | 58 | L 1-3 | 32-26 | 3 | 31,038 | Carlos Perez | Tim Hudson | Jeff Tam | Antonio Osuna | Jason Isringhausen | 344 | 288 | 56 |
| 2000-06-10 | vs OAK | 59 | W 7-2 | 33-26 | 3 | 38,621 | Kevin Brown | Omar Olivares | Kevin Brown | Omar Olivares | | 351 | 290 | 61 |
| 2000-06-11 | vs OAK | 60 | L 0-6 | 33-27 | 3 | 38,733 | Eric Gagne | Kevin Appier | Kevin Appier | Eric Gagne | | 351 | 296 | 55 |
| 2000-06-12 | vs ARI | 61 | L 2-4 | 33-28 | 3 | 25,552 | Darren Dreifort | Brian Anderson | Brian Anderson | Darren Dreifort | Byung-Hyun Kim | 353 | 300 | 53 |
| 2000-06-13 | vs ARI | 62 | W 6-1 | 34-28 | 3 | 34,067 | Chan Ho Park | Mike Morgan | Chan Ho Park | Mike Morgan | | 359 | 301 | 58 |
| 2000-06-14 | vs ARI | 63 | L 1-5 | 34-29 | 3 | 27,332 | Carlos Perez | Randy Johnson | Randy Johnson | Carlos Perez | | 360 | 306 | 54 |
| 2000-06-15 | vs ARI | 64 | W 4-0 | 35-29 | 3 | 30,103 | Kevin Brown | Todd Stottlemyre | Kevin Brown | Todd Stottlemyre | | 364 | 306 | 58 |
| 2000-06-16 | vs SLN | 65 | L 3-6 | 35-30 | 3 | 43,971 | Orel Hershiser | Pat Hentgen | Pat Hentgen | Orel Hershiser | Dave Veres | 367 | 312 | 55 |
| 2000-06-17 | vs SLN | 66 | L 3-4 | 35-31 | 3 | 46,048 | Darren Dreifort | Andy Benes | Andy Benes | Darren Dreifort | Dave Veres | 370 | 316 | 54 |
| 2000-06-18 | vs SLN | 67 | W 6-3 | 36-31 | 3 | 50,713 | Chan Ho Park | Darryl Kile | Chan Ho Park | Darryl Kile | Jeff Shaw | 376 | 319 | 57 |
| 2000-06-20 | @ HOU | 68 | W 9-6 | 37-31 | 3 | 36,354 | Kevin Brown | Chris Holt | Matt Herges | Joe Slusarski | | 385 | 325 | 60 |
| 2000-06-21 | @ HOU | 69 | W 7-6 | 38-31 | 3 | 35,356 | Carlos Perez | Octavio Dotel | Matt Herges | Jose Cabrera | | 392 | 331 | 61 |
| 2000-06-22 | @ HOU | 70 | L 3-6 | 38-32 | 3 | 37,150 | Darren Dreifort | Scott Elarton | Scott Elarton | Darren Dreifort | Marc Valdes | 395 | 337 | 58 |
| 2000-06-23 | @ SLN | 71 | L 6-9 | 38-33 | 3 | 48,395 | Chan Ho Park | Andy Benes | Gene Stechschulte | Jeff Shaw | | 401 | 346 | 55 |
| 2000-06-24 | @ SLN | 72 | L 1-6 | 38-34 | 3 | 47,071 | Orel Hershiser | Darryl Kile | Alan Benes | Orel Hershiser | | 402 | 352 | 50 |
| 2000-06-25 | @ SLN | 73 | L 1-2 | 38-35 | 4 | 47,062 | Kevin Brown | Rick Ankiel | Heathcliff Slocumb | Antonio Osuna | | 403 | 354 | 49 |
| 2000-06-26 | vs SDN | 74 | L 5-9 | 38-36 | 4 | 26,417 | Orel Hershiser | Brian Meadows | Brian Meadows | Orel Hershiser | | 408 | 363 | 45 |
| 2000-06-27 | vs SDN | 75 | W 5-4 | 39-36 | 4 | 41,897 | Eric Gagne | Will Cunnane | Mike Fetters | Matt Whiteside | | 413 | 367 | 46 |
| 2000-06-28 | vs SDN | 76 | W 5-4 | 40-36 | 3 | 32,351 | Chan Ho Park | Adam Eaton | Terry Adams | Steve Montgomery | | 418 | 371 | 47 |
| 2000-06-29 | vs SDN | 77 | L 4-5 | 40-37 | 3 | 50,171 | Darren Dreifort | Matt Clement | Matt Clement | Darren Dreifort | Trevor Hoffman | 422 | 376 | 46 |
| 2000-06-30 | @ SFN | 78 | W 9-2 | 41-37 | 3 | 40,930 | Kevin Brown | Russ Ortiz | Kevin Brown | Russ Ortiz | | 431 | 378 | 53 |
| 2000-07-01 | @ SFN | 79 | L 1-4 | 41-38 | 3 | 40,930 | Carlos Perez | Kirk Rueter | Kirk Rueter | Carlos Perez | Robb Nen | 432 | 382 | 50 |
| 2000-07-02 | @ SFN | 80 | L 5-6 | 41-39 | 4 | 40,930 | Eric Gagne | Shawn Estes | Robb Nen | Mike Fetters | | 437 | 388 | 49 |
| 2000-07-04 | @ SDN | 81 | L 2-7 | 41-40 | 4 | 51,285 | Chan Ho Park | Matt Clement | Matt Clement | Chan Ho Park | | 439 | 395 | 44 |
| 2000-07-05 | @ SDN | 82 | W 7-5 | 42-40 | 4 | 27,002 | Darren Dreifort | Brian Tollberg | Antonio Osuna | Matt Whiteside | Mike Fetters | 446 | 400 | 46 |
| 2000-07-06 | @ SDN | 83 | W 9-3 | 43-40 | 4 | 30,902 | Kevin Brown | Brian Meadows | Kevin Brown | Brian Meadows | | 455 | 403 | 52 |
| 2000-07-07 | @ SEA | 84 | W 3-2 | 44-40 | 4 | 45,206 | Carlos Perez | Freddy Garcia | Matt Herges | Arthur Rhodes | Mike Fetters | 458 | 405 | 53 |
| 2000-07-08 | @ SEA | 85 | L 0-11 | 44-41 | 4 | 45,248 | Eric Gagne | Aaron Sele | Aaron Sele | Eric Gagne | | 458 | 416 | 42 |
| 2000-07-09 | @ SEA | 86 | L 0-2 | 44-42 | 4 | 45,251 | Chan Ho Park | Jamie Moyer | Jamie Moyer | Chan Ho Park | Kazuhiro Sasaki | 458 | 418 | 40 |
| 2000-07-13 | vs ANA | 87 | W 4-3 | 45-42 | 4 | 35,456 | Carlos Perez | Ken Hill | Antonio Osuna | Al Levine | | 462 | 421 | 41 |
| 2000-07-14 | vs ANA | 88 | L 3-5 | 45-43 | 4 | 53,115 | Kevin Brown | Kent Bottenfield | Kent Bottenfield | Kevin Brown | Troy Percival | 465 | 426 | 39 |
| 2000-07-15 | vs ANA | 89 | L 2-6 | 45-44 | 4 | 42,726 | Chan Ho Park | Seth Etherton | Seth Etherton | Chan Ho Park | | 467 | 432 | 35 |
| 2000-07-16 | vs PIT | 90 | W 7-3 | 46-44 | 4 | 34,116 | Eric Gagne | Jimmy Anderson | Terry Adams | Mike Williams | | 474 | 435 | 39 |
| 2000-07-17 | vs PIT | 91 | W 9-6 | 47-44 | 3 | 25,261 | Darren Dreifort | Bronson Arroyo | Darren Dreifort | Bronson Arroyo | Jeff Shaw | 483 | 441 | 42 |
| 2000-07-18 | vs PIT | 92 | L 6-8 | 47-45 | 4 | 34,872 | Mike Judd | Todd Ritchie | Josias Manzanillo | Mike Judd | Mike Williams | 489 | 449 | 40 |
| 2000-07-19 | vs COL | 93 | W 9-1 | 48-45 | 3 | 26,889 | Kevin Brown | Rolando Arrojo | Kevin Brown | Rolando Arrojo | | 498 | 450 | 48 |
| 2000-07-20 | vs COL | 94 | W 6-3 | 49-45 | 3 | 33,619 | Chan Ho Park | Masato Yoshii | Chan Ho Park | Masato Yoshii | Mike Fetters | 504 | 453 | 51 |
| 2000-07-21 | vs SFN | 95 | W 6-5 | 50-45 | 3 | 53,563 | Carlos Perez | Shawn Estes | Matt Herges | Felix Rodriguez | Jeff Shaw | 510 | 458 | 52 |
| 2000-07-22 | vs SFN | 96 | L 2-5 | 50-46 | 3 | 45,705 | Eric Gagne | Livan Hernandez | Livan Hernandez | Eric Gagne | Robb Nen | 512 | 463 | 49 |
| 2000-07-23 | vs SFN | 97 | W 5-0 | 51-46 | 3 | 47,969 | Darren Dreifort | Russ Ortiz | Darren Dreifort | Russ Ortiz | | 517 | 463 | 54 |
| 2000-07-24 | @ COL | 98 | W 4-1 | 52-46 | 3 | 39,425 | Kevin Brown | Rolando Arrojo | Kevin Brown | Rolando Arrojo | Mike Fetters | 521 | 464 | 57 |
| 2000-07-25 | @ COL | 99 | W 6-4 | 53-46 | 3 | 41,220 | Chan Ho Park | Masato Yoshii | Chan Ho Park | Bobby Chouinard | Jeff Shaw | 527 | 468 | 59 |
| 2000-07-26 | @ COL | 100 | L 4-11 | 53-47 | 3 | 40,301 | Carlos Perez | Brian Bohanon | Brian Bohanon | Carlos Perez | | 531 | 479 | 52 |
| 2000-07-27 | @ COL | 101 | W 16-11 | 54-47 | 3 | 40,724 | Eric Gagne | Kevin Jarvis | Onan Masaoka | Giovanni Carrara | | 547 | 490 | 57 |
| 2000-07-28 | @ PHI | 102 | W 2-0 | 55-47 | 3 | 20,110 | Darren Dreifort | Omar Daal | Darren Dreifort | Omar Daal | Jeff Shaw | 549 | 490 | 59 |
| 2000-07-29 | @ PHI | 103 | L 0-3 | 55-48 | 3 | 35,189 | Kevin Brown | Cliff Politte | Cliff Politte | Kevin Brown | Jeff Brantley | 549 | 493 | 56 |
| 2000-07-30 | @ PHI | 104 | L 2-3 | 55-49 | 3 | 23,301 | Chan Ho Park | Randy Wolf | Randy Wolf | Chan Ho Park | Jeff Brantley | 551 | 496 | 55 |
| 2000-08-01 | @ PIT | 105 | L 0-6 | 56-50 | 3 | 0 | Carlos Perez | Jimmy Anderson | Jimmy Anderson | Carlos Perez | | 551 | 502 | 49 |
| 2000-08-01 | @ PIT | 106 | W 5-3 | 56-50 | 3 | 21,028 | Ismael Valdez | Bronson Arroyo | Matt Herges | Marc Wilkins | Jeff Shaw | 556 | 505 | 51 |
| 2000-08-02 | @ PIT | 107 | W 11-5 | 57-50 | 3 | 19,537 | Darren Dreifort | Jose Silva | Darren Dreifort | Jose Silva | | 567 | 510 | 57 |
| 2000-08-04 | vs MIL | 108 | W 2-1 | 58-50 | 3 | 36,074 | Kevin Brown | Paul Rigdon | Mike Fetters | Juan Acevedo | | 569 | 511 | 58 |
| 2000-08-05 | vs MIL | 109 | L 2-4 | 58-51 | 3 | 42,580 | Chan Ho Park | Jeff D'Amico | Juan Acevedo | Mike Fetters | Curt Leskanic | 571 | 515 | 56 |
| 2000-08-06 | vs MIL | 110 | L 6-9 | 58-52 | 3 | 40,275 | Ismael Valdez | Jimmy Haynes | Jimmy Haynes | Ismael Valdez | Curt Leskanic | 577 | 524 | 53 |
| 2000-08-07 | vs CHN | 111 | L 3-7 | 58-53 | 3 | 31,697 | Matt Herges | Ruben Quevedo | Ruben Quevedo | Matt Herges | | 580 | 531 | 49 |
| 2000-08-08 | vs CHN | 112 | W 7-5 | 59-53 | 3 | 46,373 | Darren Dreifort | Phil Norton | Darren Dreifort | Phil Norton | Jeff Shaw | 587 | 536 | 51 |
| 2000-08-09 | vs CHN | 113 | L 4-5 | 59-54 | 3 | 39,753 | Kevin Brown | Jon Lieber | Tim Worrell | Antonio Osuna | Rick Aguilera | 591 | 541 | 50 |
| 2000-08-11 | @ ATL | 114 | L 2-7 | 59-55 | 3 | 48,824 | Chan Ho Park | Kevin Millwood | Mike Remlinger | Terry Adams | | 593 | 548 | 45 |
| 2000-08-12 | @ ATL | 115 | L 1-4 | 59-56 | 3 | 47,806 | Ismael Valdez | Greg Maddux | Greg Maddux | Ismael Valdez | Kerry Ligtenberg | 594 | 552 | 42 |
| 2000-08-13 | @ ATL | 116 | W 7-2 | 60-56 | 3 | 40,443 | Darren Dreifort | Andy Ashby | Darren Dreifort | Andy Ashby | | 601 | 554 | 47 |
| 2000-08-14 | @ FLO | 117 | L 2-11 | 60-57 | 3 | 8,345 | Kevin Brown | Jesus Sanchez | Jesus Sanchez | Kevin Brown | | 603 | 565 | 38 |
| 2000-08-15 | @ FLO | 118 | L 3-7 | 60-58 | 3 | 9,380 | Matt Herges | Ryan Dempster | Ryan Dempster | Matt Herges | | 606 | 572 | 34 |
| 2000-08-16 | @ FLO | 119 | W 10-4 | 61-58 | 3 | 11,855 | Ismael Valdez | A.J. Burnett | Terry Adams | Dan Miceli | | 616 | 576 | 40 |
| 2000-08-18 | vs NYN | 120 | L 3-5 | 61-59 | 3 | 47,486 | Kevin Brown | Al Leiter | Rick White | Terry Adams | Armando Benitez | 619 | 581 | 38 |
| 2000-08-19 | vs NYN | 121 | W 4-1 | 62-59 | 3 | 53,051 | Chan Ho Park | Rick Reed | Chan Ho Park | Rick Reed | | 623 | 582 | 41 |
| 2000-08-20 | vs NYN | 122 | L 6-9 | 62-60 | 3 | 46,122 | Darren Dreifort | Robert Joseph Jones | Turk Wendell | Terry Adams | Armando Benitez | 629 | 591 | 38 |
| 2000-08-21 | vs MON | 123 | L 1-4 | 62-61 | 3 | 32,053 | Matt Herges | Dustin Hermanson | Dustin Hermanson | Matt Herges | Scott Strickland | 630 | 595 | 35 |
| 2000-08-22 | vs MON | 124 | W 14-6 | 63-61 | 3 | 29,804 | Ismael Valdez | Trey Moore | Terry Adams | Julio Santana | | 644 | 601 | 43 |
| 2000-08-23 | vs MON | 125 | W 5-1 | 64-61 | 3 | 31,337 | Kevin Brown | Mike Thurman | Kevin Brown | Mike Thurman | | 649 | 602 | 47 |
| 2000-08-24 | vs MON | 126 | W 7-0 | 65-61 | 3 | 28,896 | Chan Ho Park | Javier Vazquez | Chan Ho Park | Javier Vazquez | | 656 | 602 | 54 |
| 2000-08-25 | @ CHN | 127 | W 5-3 | 67-61 | 3 | 0 | Darren Dreifort | Jon Lieber | Antonio Osuna | Jon Lieber | Jeff Shaw | 661 | 605 | 56 |
| 2000-08-25 | @ CHN | 128 | W 3-1 | 67-61 | 3 | 38,854 | Carlos Perez | Daniel Garibay | Carlos Perez | Daniel Garibay | Jeff Shaw | 664 | 606 | 58 |
| 2000-08-26 | @ CHN | 129 | L 4-6 | 67-62 | 3 | 38,710 | Matt Herges | Kevin Tapani | Tim Worrell | Gregg Olson | Rick Aguilera | 668 | 612 | 56 |
| 2000-08-27 | @ CHN | 130 | W 7-6 | 68-62 | 3 | 37,557 | Ismael Valdez | Kerry Wood | Mike Fetters | Todd Van Poppel | Jeff Shaw | 675 | 618 | 57 |
| 2000-08-28 | @ MIL | 131 | W 5-3 | 69-62 | 3 | 17,167 | Kevin Brown | Jeff D'Amico | Kevin Brown | Jeff D'Amico | Jeff Shaw | 680 | 621 | 59 |
| 2000-08-29 | @ MIL | 132 | W 7-2 | 70-62 | 3 | 14,179 | Chan Ho Park | Jimmy Haynes | Chan Ho Park | Jimmy Haynes | | 687 | 623 | 64 |
| 2000-08-30 | @ MIL | 133 | L 2-3 | 70-63 | 3 | 15,940 | Darren Dreifort | Jamey Wright | Ray King | Terry Adams | | 689 | 626 | 63 |
| 2000-08-31 | @ MIL | 134 | L 2-8 | 70-64 | 3 | 15,483 | Carlos Perez | Paul Rigdon | Paul Rigdon | Carlos Perez | | 691 | 634 | 57 |
| 2000-09-01 | vs PHI | 135 | W 2-1 | 71-64 | 3 | 28,383 | Ismael Valdez | Randy Wolf | Mike Fetters | Chris Brock | Jeff Shaw | 693 | 635 | 58 |
| 2000-09-02 | vs PHI | 136 | W 1-0 | 72-64 | 3 | 37,244 | Kevin Brown | Bruce Chen | Matt Herges | Vicente Padilla | | 694 | 635 | 59 |
| 2000-09-03 | vs PHI | 137 | W 6-1 | 73-64 | 3 | 38,150 | Chan Ho Park | Robert Person | Chan Ho Park | Robert Person | Jeff Shaw | 700 | 636 | 64 |
| 2000-09-04 | vs PIT | 138 | L 1-12 | 73-65 | 3 | 31,418 | Darren Dreifort | Jimmy Anderson | Jimmy Anderson | Darren Dreifort | | 701 | 648 | 53 |
| 2000-09-05 | vs PIT | 139 | L 0-8 | 73-66 | 3 | 22,780 | Carlos Perez | Jose Silva | Jose Silva | Carlos Perez | | 701 | 656 | 45 |
| 2000-09-06 | vs PIT | 140 | L 3-8 | 73-67 | 3 | 28,462 | Ismael Valdez | Dan Serafini | Dan Serafini | Ismael Valdez | | 704 | 664 | 40 |
| 2000-09-08 | @ COL | 141 | L 5-8 | 73-68 | 3 | 37,647 | Kevin Brown | Brian Bohanon | Brian Bohanon | Kevin Brown | | 709 | 672 | 37 |
| 2000-09-09 | @ COL | 142 | L 6-7 | 73-69 | 4 | 37,241 | Chan Ho Park | Brian Rose | Gabe White | Chan Ho Park | Jose Jimenez | 715 | 679 | 36 |
| 2000-09-10 | @ COL | 143 | W 12-1 | 74-69 | 3 | 36,273 | Darren Dreifort | Pedro Astacio | Darren Dreifort | Pedro Astacio | Matt Herges | 727 | 680 | 47 |
| 2000-09-11 | @ ARI | 144 | W 6-3 | 75-69 | 3 | 37,589 | Eric Gagne | Armando Reynoso | Eric Gagne | Armando Reynoso | | 733 | 683 | 50 |
| 2000-09-12 | @ ARI | 145 | L 4-5 | 75-70 | 3 | 32,102 | Luke Prokopec | Curt Schilling | Byung-Hyun Kim | Onan Masaoka | Matt Mantei | 737 | 688 | 49 |
| 2000-09-13 | @ ARI | 146 | L 2-3 | 75-71 | 4 | 34,526 | Kevin Brown | Brian Anderson | Dan Plesac | Terry Adams | | 739 | 691 | 48 |
| 2000-09-14 | vs COL | 147 | L 4-5 | 75-72 | 4 | 24,368 | Chan Ho Park | Brian Rose | Brian Rose | Chan Ho Park | Jose Jimenez | 743 | 696 | 47 |
| 2000-09-15 | vs COL | 148 | W 4-3 | 76-72 | 4 | 33,009 | Darren Dreifort | Pedro Astacio | Matt Herges | Mike DeJean | | 747 | 699 | 48 |
| 2000-09-16 | vs COL | 149 | W 5-4 | 77-72 | 3 | 36,464 | Eric Gagne | Julian Tavarez | Eric Gagne | Julian Tavarez | Jeff Shaw | 752 | 703 | 49 |
| 2000-09-17 | vs COL | 150 | W 12-6 | 78-72 | 3 | 36,498 | Luke Prokopec | Masato Yoshii | Luke Prokopec | Masato Yoshii | | 764 | 709 | 55 |
| 2000-09-18 | vs ARI | 151 | W 2-1 | 79-72 | 3 | 31,345 | Kevin Brown | Armando Reynoso | Jeff Shaw | Greg Swindell | | 766 | 710 | 56 |
| 2000-09-19 | vs ARI | 152 | W 1-0 | 80-72 | 3 | 29,753 | Chan Ho Park | Brian Anderson | Chan Ho Park | Brian Anderson | Jeff Shaw | 767 | 710 | 57 |
| 2000-09-20 | vs ARI | 153 | W 1-0 | 81-72 | 2 | 31,630 | Darren Dreifort | Randy Johnson | Matt Herges | Byung-Hyun Kim | | 768 | 710 | 58 |
| 2000-09-22 | vs SDN | 154 | L 2-3 | 81-73 | 3 | 37,512 | Eric Gagne | Jay Witasick | Dave Maurer | Antonio Osuna | Trevor Hoffman | 770 | 713 | 57 |
| 2000-09-23 | vs SDN | 155 | W 2-1 | 82-73 | 2 | 40,623 | Kevin Brown | Woody Williams | Kevin Brown | Woody Williams | | 772 | 714 | 58 |
| 2000-09-24 | vs SDN | 156 | W 1-0 | 83-73 | 2 | 46,393 | Chan Ho Park | Matt Clement | Chan Ho Park | Matt Clement | Jeff Shaw | 773 | 714 | 59 |
| 2000-09-26 | vs SFN | 157 | W 9-0 | 84-73 | 2 | 43,909 | Darren Dreifort | Russ Ortiz | Darren Dreifort | Russ Ortiz | | 782 | 714 | 68 |
| 2000-09-27 | vs SFN | 158 | L 0-4 | 84-74 | 2 | 44,232 | Luke Prokopec | Kirk Rueter | Kirk Rueter | Luke Prokopec | | 782 | 718 | 64 |
| 2000-09-28 | vs SFN | 159 | L 3-5 | 84-75 | 3 | 44,513 | Kevin Brown | Shawn Estes | Aaron Fultz | Terry Adams | Robb Nen | 785 | 723 | 62 |
| 2000-09-29 | @ SDN | 160 | W 3-0 | 85-75 | 2 | 40,382 | Chan Ho Park | Woody Williams | Chan Ho Park | Woody Williams | | 788 | 723 | 65 |
| 2000-09-30 | @ SDN | 161 | W 10-2 | 86-75 | 2 | 50,267 | Eric Gagne | Matt Clement | Eric Gagne | Matt Clement | | 798 | 725 | 73 |
| 2000-10-01 | @ SDN | 162 | L 0-4 | 86-76 | 2 | 43,691 | Darren Dreifort | Adam Eaton | Adam Eaton | Darren Dreifort | Trevor Hoffman | 798 | 729 | 69 |