| 1997-04-01 | @ TOR | 1 | W 6-5 | 1-0 | 1 | 40,299 | Jaime Navarro | Pat Hentgen | Tony Castillo | Dan Plesac | Roberto Hernandez | 6 | 5 | 1 |
| 1997-04-02 | @ TOR | 2 | L 1-6 | 1-1 | 3 | 31,310 | Wilson Alvarez | Roger Clemens | Roger Clemens | Wilson Alvarez | | 7 | 11 | -4 |
| 1997-04-04 | vs DET | 3 | L 7-8 | 1-2 | 2 | 38,560 | James Baldwin | Brian Moehler | Todd Jones | Al Levine | A.J. Sager | 14 | 19 | -5 |
| 1997-04-05 | vs DET | 4 | L 12-15 | 1-3 | 4 | 21,956 | Doug Drabek | Omar Olivares | Willie Blair | Tony Castillo | Todd Jones | 26 | 34 | -8 |
| 1997-04-06 | vs DET | 5 | W 5-3 | 2-3 | 4 | 19,259 | Jaime Navarro | Doug Brocail | Jaime Navarro | Doug Brocail | Roberto Hernandez | 31 | 37 | -6 |
| 1997-04-09 | vs TOR | 6 | L 0-5 | 2-4 | 5 | 746 | Wilson Alvarez | Roger Clemens | Roger Clemens | Wilson Alvarez | | 31 | 42 | -11 |
| 1997-04-10 | vs TOR | 7 | L 0-4 | 2-5 | 5 | 14,180 | James Baldwin | Juan Guzman | Juan Guzman | James Baldwin | | 31 | 46 | -15 |
| 1997-04-11 | @ DET | 8 | L 4-5 | 2-6 | 5 | 7,598 | Doug Drabek | Omar Olivares | Omar Olivares | Doug Drabek | Todd Jones | 35 | 51 | -16 |
| 1997-04-13 | @ DET | 9 | W 11-8 | 3-7 | 5 | 0 | Jaime Navarro | Doug Brocail | Roberto Hernandez | Felipe Lira | | 46 | 59 | -13 |
| 1997-04-13 | @ DET | 10 | L 2-4 | 3-7 | 5 | 10,818 | Danny Darwin | Justin Thompson | A.J. Sager | Roberto Hernandez | | 48 | 63 | -15 |
| 1997-04-14 | @ TEX | 11 | L 1-3 | 3-8 | 5 | 27,891 | Wilson Alvarez | Ken Hill | Danny Patterson | Wilson Alvarez | John Wetteland | 49 | 66 | -17 |
| 1997-04-15 | @ TEX | 12 | L 2-5 | 3-9 | 5 | 27,990 | James Baldwin | Bobby Witt | Bobby Witt | James Baldwin | John Wetteland | 51 | 71 | -20 |
| 1997-04-16 | vs BAL | 13 | W 9-3 | 4-9 | 5 | 14,061 | Doug Drabek | Shawn Boskie | Doug Drabek | Shawn Boskie | | 60 | 74 | -14 |
| 1997-04-17 | vs BAL | 14 | L 0-1 | 4-10 | 5 | 14,674 | Danny Darwin | Mike Mussina | Mike Mussina | Danny Darwin | Randy Myers | 60 | 75 | -15 |
| 1997-04-18 | vs NYA | 15 | L 4-10 | 4-11 | 5 | 18,603 | Jaime Navarro | Ramiro Mendoza | Ramiro Mendoza | Jaime Navarro | | 64 | 85 | -21 |
| 1997-04-19 | vs NYA | 16 | L 2-3 | 4-12 | 5 | 24,976 | Wilson Alvarez | Kenny Rogers | Kenny Rogers | Tony Castillo | Mariano Rivera | 66 | 88 | -22 |
| 1997-04-20 | vs NYA | 17 | W 8-7 | 5-12 | 5 | 23,601 | James Baldwin | David Wells | Al Levine | Brian Boehringer | | 74 | 95 | -21 |
| 1997-04-21 | vs NYA | 18 | L 3-4 | 5-13 | 5 | 16,694 | Doug Drabek | David Cone | David Cone | Doug Drabek | Mariano Rivera | 77 | 99 | -22 |
| 1997-04-22 | @ BAL | 19 | L 2-3 | 5-14 | 5 | 38,392 | Danny Darwin | Mike Mussina | Mike Mussina | Danny Darwin | Randy Myers | 79 | 102 | -23 |
| 1997-04-23 | @ BAL | 20 | W 11-9 | 6-14 | 5 | 42,902 | Jaime Navarro | Rocky Coppinger | Tony Castillo | Armando Benitez | Roberto Hernandez | 90 | 111 | -21 |
| 1997-04-25 | @ NYA | 21 | W 9-3 | 7-14 | 5 | 24,648 | Wilson Alvarez | David Wells | Wilson Alvarez | David Wells | | 99 | 114 | -15 |
| 1997-04-26 | @ NYA | 22 | L 2-10 | 7-15 | 5 | 28,817 | James Baldwin | David Cone | David Cone | James Baldwin | Mariano Rivera | 101 | 124 | -23 |
| 1997-04-27 | @ NYA | 23 | L 1-7 | 7-16 | 5 | 36,133 | Doug Drabek | Andy Pettitte | Andy Pettitte | Doug Drabek | | 102 | 131 | -29 |
| 1997-04-29 | vs TEX | 24 | W 2-1 | 8-16 | 5 | 16,143 | Jaime Navarro | Roger Pavlik | Jaime Navarro | Danny Patterson | | 104 | 132 | -28 |
| 1997-04-30 | vs TEX | 25 | L 2-6 | 8-17 | 5 | 14,034 | Wilson Alvarez | Ken Hill | Bobby Witt | Wilson Alvarez | | 106 | 138 | -32 |
| 1997-05-03 | vs ANA | 26 | L 2-3 | 9-18 | 5 | 0 | James Baldwin | Allen Watson | Allen Watson | James Baldwin | Rich DeLucia | 108 | 141 | -33 |
| 1997-05-03 | vs ANA | 27 | W 4-2 | 9-18 | 5 | 24,004 | Doug Drabek | Dennis Springer | Doug Drabek | Dennis Springer | Roberto Hernandez | 112 | 143 | -31 |
| 1997-05-04 | vs ANA | 28 | W 4-2 | 10-18 | 5 | 22,181 | Jaime Navarro | Shigetoshi Hasegawa | Jaime Navarro | Pep Harris | Roberto Hernandez | 116 | 145 | -29 |
| 1997-05-06 | vs SEA | 29 | L 6-7 | 10-19 | 5 | 19,136 | Wilson Alvarez | Dennis Martinez | Bobby Ayala | Tony Castillo | Norm Charlton | 122 | 152 | -30 |
| 1997-05-08 | vs OAK | 30 | W 10-6 | 11-19 | 5 | 16,627 | James Baldwin | Mike Mohler | James Baldwin | Mike Mohler | | 132 | 158 | -26 |
| 1997-05-09 | vs OAK | 31 | W 3-2 | 12-19 | 5 | 16,295 | Jaime Navarro | Ariel Prieto | Roberto Hernandez | Aaron Small | | 135 | 160 | -25 |
| 1997-05-10 | vs OAK | 32 | W 9-8 | 13-19 | 4 | 28,816 | Doug Drabek | Dave Telgheder | Al Levine | Billy Taylor | | 144 | 168 | -24 |
| 1997-05-11 | vs OAK | 33 | W 8-5 | 14-19 | 4 | 17,518 | Wilson Alvarez | Willie Adams | Wilson Alvarez | Willie Adams | Roberto Hernandez | 152 | 173 | -21 |
| 1997-05-12 | @ ANA | 34 | L 8-16 | 14-20 | 4 | 14,540 | Danny Darwin | Allen Watson | Rich DeLucia | Al Levine | | 160 | 189 | -29 |
| 1997-05-13 | @ ANA | 35 | L 7-8 | 14-21 | 4 | 14,806 | James Baldwin | Mark Langston | Mark Langston | James Baldwin | Mike James | 167 | 197 | -30 |
| 1997-05-14 | @ SEA | 36 | L 7-9 | 14-22 | 4 | 31,374 | Jaime Navarro | Jamie Moyer | Jamie Moyer | Jaime Navarro | Norm Charlton | 174 | 206 | -32 |
| 1997-05-15 | @ SEA | 37 | W 4-3 | 15-22 | 4 | 29,225 | Doug Drabek | Jeff Fassero | Bill Simas | Norm Charlton | Roberto Hernandez | 178 | 209 | -31 |
| 1997-05-16 | @ OAK | 38 | W 6-2 | 16-22 | 4 | 14,237 | Wilson Alvarez | Willie Adams | Wilson Alvarez | Willie Adams | Roberto Hernandez | 184 | 211 | -27 |
| 1997-05-17 | @ OAK | 39 | W 7-6 | 17-22 | 4 | 20,140 | Danny Darwin | Steve Karsay | Danny Darwin | Steve Karsay | Roberto Hernandez | 191 | 217 | -26 |
| 1997-05-18 | @ OAK | 40 | W 10-4 | 18-22 | 4 | 45,227 | James Baldwin | Mike Mohler | James Baldwin | Mike Mohler | | 201 | 221 | -20 |
| 1997-05-20 | vs BOS | 41 | W 10-1 | 19-22 | 4 | 16,563 | Jaime Navarro | Tim Wakefield | Jaime Navarro | Tim Wakefield | | 211 | 222 | -11 |
| 1997-05-21 | vs BOS | 42 | W 10-5 | 20-22 | 3 | 18,814 | Doug Drabek | Chris Hammond | Doug Drabek | Chris Hammond | | 221 | 227 | -6 |
| 1997-05-23 | vs MIL | 43 | L 1-4 | 20-23 | 3 | 28,160 | Wilson Alvarez | Scott Karl | Scott Karl | Wilson Alvarez | Doug Jones | 222 | 231 | -9 |
| 1997-05-24 | vs MIL | 44 | W 8-6 | 21-23 | 3 | 30,872 | Danny Darwin | Jeff D'Amico | Bill Simas | Mike Fetters | Roberto Hernandez | 230 | 237 | -7 |
| 1997-05-25 | vs MIL | 45 | L 7-11 | 21-24 | 4 | 29,158 | James Baldwin | Cal Eldred | Joel Adamson | James Baldwin | Bob Wickman | 237 | 248 | -11 |
| 1997-05-26 | vs CLE | 46 | L 4-10 | 21-25 | 4 | 26,383 | Jaime Navarro | Orel Hershiser | Orel Hershiser | Jaime Navarro | | 241 | 258 | -17 |
| 1997-05-27 | vs CLE | 47 | W 8-2 | 22-25 | 3 | 20,847 | Doug Drabek | Albie Lopez | Doug Drabek | Albie Lopez | | 249 | 260 | -11 |
| 1997-05-28 | @ BOS | 48 | L 3-5 | 22-26 | 3 | 28,078 | Wilson Alvarez | Aaron Sele | Aaron Sele | Wilson Alvarez | Heathcliff Slocumb | 252 | 265 | -13 |
| 1997-05-29 | @ BOS | 49 | W 5-2 | 23-26 | 3 | 27,775 | Danny Darwin | Jeff Suppan | Roberto Hernandez | John Wasdin | Bill Simas | 257 | 267 | -10 |
| 1997-05-30 | @ MIL | 50 | L 0-5 | 23-27 | 3 | 28,619 | James Baldwin | Cal Eldred | Cal Eldred | James Baldwin | | 257 | 272 | -15 |
| 1997-05-31 | @ MIL | 51 | L 3-4 | 23-28 | 3 | 30,048 | Jaime Navarro | Ben McDonald | Ben McDonald | Jaime Navarro | Doug Jones | 260 | 276 | -16 |
| 1997-06-01 | @ MIL | 52 | L 4-7 | 23-29 | 4 | 30,140 | Doug Drabek | Jose Mercedes | Jose Mercedes | Doug Drabek | Doug Jones | 264 | 283 | -19 |
| 1997-06-02 | @ MIL | 53 | W 8-5 | 24-29 | 4 | 15,522 | Wilson Alvarez | Scott Karl | Bill Simas | Doug Jones | Roberto Hernandez | 272 | 288 | -16 |
| 1997-06-03 | @ CLE | 54 | W 9-5 | 25-29 | 4 | 42,994 | Danny Darwin | Chad Ogea | Danny Darwin | Chad Ogea | | 281 | 293 | -12 |
| 1997-06-04 | @ CLE | 55 | W 9-4 | 26-29 | 3 | 42,992 | James Baldwin | Albie Lopez | James Baldwin | Albie Lopez | | 290 | 297 | -7 |
| 1997-06-05 | @ CLE | 56 | L 4-5 | 26-30 | 3 | 42,948 | Jaime Navarro | Charles Nagy | Paul Shuey | Carlos Castillo | | 294 | 302 | -8 |
| 1997-06-06 | vs BAL | 57 | W 7-3 | 27-30 | 3 | 21,304 | Doug Drabek | Scott Erickson | Doug Drabek | Scott Erickson | Roberto Hernandez | 301 | 305 | -4 |
| 1997-06-07 | vs BAL | 58 | W 1-0 | 28-30 | 3 | 31,548 | Wilson Alvarez | Scott Kamieniecki | Roberto Hernandez | Randy Myers | | 302 | 305 | -3 |
| 1997-06-08 | vs BAL | 59 | L 1-2 | 28-31 | 4 | 24,089 | Danny Darwin | Jimmy Key | Jimmy Key | Danny Darwin | Randy Myers | 303 | 307 | -4 |
| 1997-06-09 | vs BAL | 60 | L 2-10 | 28-32 | 4 | 23,464 | James Baldwin | Mike Mussina | Mike Mussina | James Baldwin | | 305 | 317 | -12 |
| 1997-06-10 | @ NYA | 61 | L 1-12 | 28-33 | 4 | 28,079 | Jaime Navarro | Andy Pettitte | Andy Pettitte | Jaime Navarro | | 306 | 329 | -23 |
| 1997-06-11 | @ NYA | 62 | L 5-7 | 28-34 | 4 | 22,190 | Doug Drabek | Kenny Rogers | Mike Stanton | Chuck McElroy | Mariano Rivera | 311 | 336 | -25 |
| 1997-06-13 | @ CIN | 63 | W 3-1 | 29-34 | 4 | 31,682 | Wilson Alvarez | Pete Schourek | Wilson Alvarez | Pete Schourek | Roberto Hernandez | 314 | 337 | -23 |
| 1997-06-14 | @ CIN | 64 | L 1-5 | 29-35 | 5 | 36,685 | Danny Darwin | Kent Mercker | Kent Mercker | Danny Darwin | | 315 | 342 | -27 |
| 1997-06-15 | @ CIN | 65 | W 14-6 | 30-35 | 4 | 31,663 | James Baldwin | Dave Burba | Tony Castillo | Dave Burba | Carlos Castillo | 329 | 348 | -19 |
| 1997-06-16 | vs CHN | 66 | L 3-8 | 30-36 | 4 | 36,213 | Jaime Navarro | Kevin Foster | Kevin Foster | Jaime Navarro | | 332 | 356 | -24 |
| 1997-06-17 | vs CHN | 67 | W 5-3 | 31-36 | 4 | 44,249 | Doug Drabek | Geremi Gonzalez | Doug Drabek | Geremi Gonzalez | Roberto Hernandez | 337 | 359 | -22 |
| 1997-06-18 | vs CHN | 68 | W 3-0 | 32-36 | 4 | 44,204 | Wilson Alvarez | Terry Mulholland | Wilson Alvarez | Terry Mulholland | | 340 | 359 | -19 |
| 1997-06-20 | vs MIN | 69 | L 0-3 | 32-37 | 5 | 22,043 | Danny Darwin | Bob Tewksbury | Bob Tewksbury | Danny Darwin | Rick Aguilera | 340 | 362 | -22 |
| 1997-06-21 | vs MIN | 70 | W 5-3 | 33-37 | 4 | 29,676 | James Baldwin | Rich Robertson | James Baldwin | Rich Robertson | Roberto Hernandez | 345 | 365 | -20 |
| 1997-06-22 | vs MIN | 71 | W 2-1 | 34-37 | 4 | 26,082 | Jaime Navarro | LaTroy Hawkins | Jaime Navarro | LaTroy Hawkins | Roberto Hernandez | 347 | 366 | -19 |
| 1997-06-23 | vs KCA | 72 | W 7-6 | 35-37 | 3 | 28,490 | Doug Drabek | Jose Rosado | Matt Karchner | Hipolito Pichardo | Roberto Hernandez | 354 | 372 | -18 |
| 1997-06-24 | vs KCA | 73 | W 4-0 | 36-37 | 2 | 18,146 | Wilson Alvarez | Jim Pittsley | Wilson Alvarez | Jim Pittsley | Roberto Hernandez | 358 | 372 | -14 |
| 1997-06-25 | vs KCA | 74 | W 8-7 | 37-37 | 2 | 22,176 | Carlos Castillo | Tim Belcher | Matt Karchner | Jeff Montgomery | | 366 | 379 | -13 |
| 1997-06-26 | @ MIN | 75 | W 11-1 | 38-37 | 2 | 12,807 | James Baldwin | LaTroy Hawkins | James Baldwin | LaTroy Hawkins | | 377 | 380 | -3 |
| 1997-06-27 | @ MIN | 76 | W 10-6 | 39-37 | 2 | 15,095 | Jaime Navarro | Bob Tewksbury | Jaime Navarro | Bob Tewksbury | | 387 | 386 | 1 |
| 1997-06-28 | @ MIN | 77 | L 5-11 | 39-38 | 2 | 22,139 | Doug Drabek | Brad Radke | Brad Radke | Doug Drabek | | 392 | 397 | -5 |
| 1997-06-29 | @ MIN | 78 | W 6-4 | 40-38 | 2 | 23,655 | Wilson Alvarez | Dave Stevens | Wilson Alvarez | Dave Stevens | Roberto Hernandez | 398 | 401 | -3 |
| 1997-06-30 | @ PIT | 79 | L 1-3 | 40-39 | 2 | 28,070 | Danny Darwin | Jon Lieber | Jon Lieber | Danny Darwin | | 399 | 404 | -5 |
| 1997-07-01 | @ PIT | 80 | L 0-3 | 40-40 | 2 | 22,163 | James Baldwin | Steve Cooke | Steve Cooke | James Baldwin | Rich Loiselle | 399 | 407 | -8 |
| 1997-07-02 | @ PIT | 81 | L 1-3 | 40-41 | 2 | 25,772 | Jaime Navarro | Jason Schmidt | Jason Schmidt | Jaime Navarro | | 400 | 410 | -10 |
| 1997-07-03 | vs BOS | 82 | L 1-4 | 40-42 | 2 | 20,521 | Doug Drabek | Aaron Sele | Aaron Sele | Doug Drabek | | 401 | 414 | -13 |
| 1997-07-04 | vs BOS | 83 | W 6-5 | 41-42 | 2 | 30,007 | Wilson Alvarez | Jeff Suppan | Roberto Hernandez | Heathcliff Slocumb | | 407 | 419 | -12 |
| 1997-07-05 | vs BOS | 84 | W 11-8 | 42-42 | 2 | 25,802 | Danny Darwin | Steve Avery | Danny Darwin | Steve Avery | | 418 | 427 | -9 |
| 1997-07-06 | vs BOS | 85 | W 6-5 | 43-42 | 2 | 25,153 | James Baldwin | Vaughn Eshelman | James Baldwin | Tim Wakefield | Roberto Hernandez | 424 | 432 | -8 |
| 1997-07-10 | @ KCA | 86 | W 6-3 | 44-42 | 2 | 29,812 | Jaime Navarro | Kevin Appier | Jaime Navarro | Kevin Appier | Roberto Hernandez | 430 | 435 | -5 |
| 1997-07-11 | @ KCA | 87 | W 6-2 | 45-42 | 2 | 21,485 | Wilson Alvarez | Jose Rosado | Wilson Alvarez | Jose Rosado | | 436 | 437 | -1 |
| 1997-07-12 | @ KCA | 88 | W 11-7 | 46-42 | 2 | 33,155 | Danny Darwin | Tim Belcher | Danny Darwin | Tim Belcher | Roberto Hernandez | 447 | 444 | 3 |
| 1997-07-13 | @ KCA | 89 | W 7-6 | 47-42 | 2 | 27,887 | James Baldwin | Jim Pittsley | Carlos Castillo | Jim Pittsley | Roberto Hernandez | 454 | 450 | 4 |
| 1997-07-14 | @ MIN | 90 | L 3-5 | 47-43 | 2 | 15,750 | Doug Drabek | Dave Stevens | Frankie Rodriguez | Doug Drabek | Rick Aguilera | 457 | 455 | 2 |
| 1997-07-15 | @ MIN | 91 | L 4-8 | 47-44 | 2 | 14,506 | Jaime Navarro | Brad Radke | Brad Radke | Jaime Navarro | | 461 | 463 | -2 |
| 1997-07-16 | vs NYA | 92 | L 5-11 | 47-45 | 2 | 26,144 | Wilson Alvarez | Andy Pettitte | Andy Pettitte | Wilson Alvarez | | 466 | 474 | -8 |
| 1997-07-17 | vs NYA | 93 | L 2-4 | 47-46 | 2 | 31,923 | Danny Darwin | David Cone | David Cone | Danny Darwin | Mariano Rivera | 468 | 478 | -10 |
| 1997-07-18 | @ BAL | 94 | W 3-0 | 48-46 | 2 | 47,759 | James Baldwin | Mike Mussina | James Baldwin | Mike Mussina | Roberto Hernandez | 471 | 478 | -7 |
| 1997-07-19 | @ BAL | 95 | L 3-8 | 48-47 | 2 | 47,857 | Doug Drabek | Scott Kamieniecki | Arthur Rhodes | Bill Simas | Armando Benitez | 474 | 486 | -12 |
| 1997-07-20 | @ BAL | 96 | W 10-2 | 49-47 | 2 | 47,800 | Jaime Navarro | Shawn Boskie | Jaime Navarro | Shawn Boskie | | 484 | 488 | -4 |
| 1997-07-21 | @ DET | 97 | W 3-0 | 50-47 | 2 | 14,260 | Wilson Alvarez | Justin Thompson | Wilson Alvarez | Justin Thompson | Roberto Hernandez | 487 | 488 | -1 |
| 1997-07-22 | @ DET | 98 | L 3-6 | 50-48 | 2 | 16,895 | Danny Darwin | Brian Moehler | Brian Moehler | Danny Darwin | Todd Jones | 490 | 494 | -4 |
| 1997-07-23 | @ DET | 99 | L 6-8 | 50-49 | 2 | 18,525 | James Baldwin | Willie Blair | Willie Blair | James Baldwin | Todd Jones | 496 | 502 | -6 |
| 1997-07-24 | vs TEX | 100 | W 2-1 | 51-49 | 2 | 25,899 | Doug Drabek | Ken Hill | Matt Karchner | Ken Hill | Roberto Hernandez | 498 | 503 | -5 |
| 1997-07-25 | vs TEX | 101 | L 5-8 | 51-50 | 2 | 33,612 | Jaime Navarro | John Burkett | Danny Patterson | Jaime Navarro | John Wetteland | 503 | 511 | -8 |
| 1997-07-26 | vs TEX | 102 | L 1-4 | 51-51 | 2 | 26,262 | Wilson Alvarez | Darren Oliver | Darren Oliver | Wilson Alvarez | John Wetteland | 504 | 515 | -11 |
| 1997-07-27 | vs TEX | 103 | L 4-5 | 51-52 | 2 | 29,558 | Danny Darwin | Tanyon Sturtze | Eric Gunderson | Tony Castillo | John Wetteland | 508 | 520 | -12 |
| 1997-07-29 | vs DET | 104 | L 1-3 | 51-53 | 3 | 20,380 | James Baldwin | Willie Blair | Willie Blair | James Baldwin | | 509 | 523 | -14 |
| 1997-07-30 | vs DET | 105 | W 3-2 | 52-53 | 3 | 30,613 | Doug Drabek | Scott Sanders | Doug Drabek | Scott Sanders | Roberto Hernandez | 512 | 525 | -13 |
| 1997-07-31 | @ ANA | 106 | W 14-12 | 53-53 | 3 | 23,297 | Jaime Navarro | Jason Dickson | Carlos Castillo | Mike Holtz | Matt Karchner | 526 | 537 | -11 |
| 1997-08-01 | @ ANA | 107 | L 1-9 | 53-54 | 3 | 20,953 | Scott Eyre | Allen Watson | Allen Watson | Scott Eyre | | 527 | 546 | -19 |
| 1997-08-02 | @ ANA | 108 | L 2-5 | 53-55 | 3 | 28,139 | Chris Clemons | Dennis Springer | Dennis Springer | Chris Clemons | Troy Percival | 529 | 551 | -22 |
| 1997-08-03 | @ ANA | 109 | L 1-4 | 53-56 | 3 | 25,041 | James Baldwin | Chuck Finley | Chuck Finley | James Baldwin | Troy Percival | 530 | 555 | -25 |
| 1997-08-05 | @ OAK | 110 | W 3-0 | 54-56 | 3 | 11,676 | Doug Drabek | Steve Karsay | Doug Drabek | Steve Karsay | Matt Karchner | 533 | 555 | -22 |
| 1997-08-06 | @ OAK | 111 | L 2-3 | 54-57 | 3 | 11,601 | Jaime Navarro | Jimmy Haynes | T.J. Mathews | Jaime Navarro | Billy Taylor | 535 | 558 | -23 |
| 1997-08-07 | @ SEA | 112 | L 2-3 | 54-58 | 3 | 29,319 | Scott Eyre | Jeff Fassero | Jeff Fassero | Scott Eyre | Heathcliff Slocumb | 537 | 561 | -24 |
| 1997-08-08 | @ SEA | 113 | L 0-5 | 54-59 | 3 | 42,170 | Chris Clemons | Randy Johnson | Randy Johnson | Chris Clemons | | 537 | 566 | -29 |
| 1997-08-09 | @ SEA | 114 | W 5-2 | 55-59 | 3 | 45,063 | James Baldwin | Ken Cloude | James Baldwin | Ken Cloude | Matt Karchner | 542 | 568 | -26 |
| 1997-08-10 | @ SEA | 115 | W 2-1 | 56-59 | 2 | 38,357 | Doug Drabek | Omar Olivares | Doug Drabek | Omar Olivares | Matt Karchner | 544 | 569 | -25 |
| 1997-08-12 | vs ANA | 116 | W 8-5 | 57-59 | 2 | 16,975 | Jaime Navarro | Jason Dickson | Jaime Navarro | Jason Dickson | Tony Castillo | 552 | 574 | -22 |
| 1997-08-13 | vs ANA | 117 | W 5-2 | 58-59 | 2 | 21,237 | Scott Eyre | Allen Watson | Scott Eyre | Allen Watson | Matt Karchner | 557 | 576 | -19 |
| 1997-08-14 | vs OAK | 118 | L 5-12 | 58-60 | 2 | 21,570 | Carlos Castillo | Willie Adams | Buddy Groom | Chuck McElroy | | 562 | 588 | -26 |
| 1997-08-15 | vs OAK | 119 | L 6-11 | 58-61 | 2 | 29,652 | James Baldwin | Jimmy Haynes | Jimmy Haynes | James Baldwin | | 568 | 599 | -31 |
| 1997-08-16 | vs SEA | 120 | L 6-11 | 58-62 | 2 | 40,223 | Doug Drabek | Jamie Moyer | Bobby Ayala | Doug Drabek | | 574 | 610 | -36 |
| 1997-08-17 | vs SEA | 121 | L 3-5 | 59-63 | 3 | 0 | Jaime Navarro | Jeff Fassero | Jeff Fassero | Jaime Navarro | | 577 | 615 | -38 |
| 1997-08-17 | vs SEA | 122 | W 4-2 | 59-63 | 3 | 35,571 | Mike Sirotka | Omar Olivares | Mike Sirotka | Omar Olivares | Matt Karchner | 581 | 617 | -36 |
| 1997-08-18 | vs SEA | 123 | W 5-0 | 60-63 | 2 | 31,441 | Scott Eyre | Felipe Lira | Scott Eyre | Felipe Lira | Keith Foulke | 586 | 617 | -31 |
| 1997-08-19 | vs TOR | 124 | L 5-6 | 61-64 | 3 | 0 | Tom Fordham | Chris Carpenter | Chris Carpenter | Nelson Cruz | Kelvim Escobar | 591 | 623 | -32 |
| 1997-08-19 | vs TOR | 125 | W 5-3 | 61-64 | 3 | 19,643 | Jason Bere | Luis Andujar | Jason Bere | Luis Andujar | Matt Karchner | 596 | 626 | -30 |
| 1997-08-20 | vs TOR | 126 | W 12-6 | 62-64 | 3 | 20,003 | James Baldwin | Robert Person | James Baldwin | Robert Person | | 608 | 632 | -24 |
| 1997-08-21 | vs TOR | 127 | W 6-3 | 63-64 | 2 | 20,120 | Doug Drabek | Pat Hentgen | Doug Drabek | Pat Hentgen | Matt Karchner | 614 | 635 | -21 |
| 1997-08-22 | @ TEX | 128 | L 8-17 | 63-65 | 2 | 33,353 | Jaime Navarro | Darren Oliver | Darren Oliver | Jaime Navarro | | 622 | 652 | -30 |
| 1997-08-23 | @ TEX | 129 | L 8-13 | 63-66 | 3 | 46,090 | Scott Eyre | Bobby Witt | Danny Patterson | Nelson Cruz | | 630 | 665 | -35 |
| 1997-08-24 | @ TEX | 130 | W 3-1 | 64-66 | 3 | 27,441 | Jason Bere | Rick Helling | Jason Bere | Rick Helling | Matt Karchner | 633 | 666 | -33 |
| 1997-08-26 | @ TOR | 131 | W 8-5 | 65-66 | 3 | 31,198 | James Baldwin | Woody Williams | James Baldwin | Woody Williams | Matt Karchner | 641 | 671 | -30 |
| 1997-08-27 | @ TOR | 132 | L 2-13 | 65-67 | 3 | 30,219 | Doug Drabek | Pat Hentgen | Pat Hentgen | Doug Drabek | | 643 | 684 | -41 |
| 1997-08-28 | @ TOR | 133 | L 2-3 | 65-68 | 3 | 36,181 | Jaime Navarro | Roger Clemens | Paul Quantrill | Chuck McElroy | | 645 | 687 | -42 |
| 1997-08-29 | vs HOU | 134 | W 5-4 | 66-68 | 3 | 21,312 | Scott Eyre | Ramon Garcia | Keith Foulke | John Hudek | Matt Karchner | 650 | 691 | -41 |
| 1997-08-30 | vs HOU | 135 | W 9-2 | 67-68 | 3 | 28,051 | Jason Bere | Mike Hampton | Jason Bere | Mike Hampton | | 659 | 693 | -34 |
| 1997-08-31 | vs HOU | 136 | W 3-1 | 68-68 | 3 | 22,916 | James Baldwin | Shane Reynolds | James Baldwin | Shane Reynolds | Matt Karchner | 662 | 694 | -32 |
| 1997-09-01 | @ SLN | 137 | W 5-4 | 69-68 | 3 | 40,464 | Doug Drabek | Matt Morris | Tony Castillo | Tony Fossas | Matt Karchner | 667 | 698 | -31 |
| 1997-09-02 | @ SLN | 138 | L 1-6 | 69-69 | 3 | 27,192 | Jaime Navarro | Andy Benes | Andy Benes | Jaime Navarro | | 668 | 704 | -36 |
| 1997-09-03 | @ SLN | 139 | L 2-4 | 69-70 | 3 | 29,088 | Scott Eyre | Manny Aybar | Manny Aybar | Scott Eyre | Dennis Eckersley | 670 | 708 | -38 |
| 1997-09-05 | @ CLE | 140 | L 1-11 | 69-71 | 3 | 43,093 | Jason Bere | Charles Nagy | Charles Nagy | Jason Bere | | 671 | 719 | -48 |
| 1997-09-06 | @ CLE | 141 | L 7-9 | 69-72 | 3 | 43,055 | James Baldwin | Bartolo Colon | Bartolo Colon | James Baldwin | Jose Mesa | 678 | 728 | -50 |
| 1997-09-07 | @ CLE | 142 | L 2-5 | 69-73 | 3 | 43,051 | Doug Drabek | Jaret Wright | Jaret Wright | Doug Drabek | Jose Mesa | 680 | 733 | -53 |
| 1997-09-08 | vs MIL | 143 | L 5-8 | 69-74 | 3 | 18,552 | Jaime Navarro | Scott Karl | Bob Wickman | Matt Karchner | Doug Jones | 685 | 741 | -56 |
| 1997-09-09 | vs MIL | 144 | W 4-1 | 70-74 | 3 | 16,515 | Scott Eyre | Jose Mercedes | Scott Eyre | Jose Mercedes | Tony Castillo | 689 | 742 | -53 |
| 1997-09-10 | vs MIL | 145 | W 3-1 | 71-74 | 3 | 16,616 | Jason Bere | Cal Eldred | Jason Bere | Cal Eldred | Chuck McElroy | 692 | 743 | -51 |
| 1997-09-11 | vs CLE | 146 | W 7-5 | 72-74 | 3 | 22,620 | James Baldwin | Charles Nagy | Keith Foulke | Charles Nagy | Matt Karchner | 699 | 748 | -49 |
| 1997-09-12 | vs CLE | 147 | L 0-9 | 72-75 | 3 | 31,249 | Doug Drabek | Jaret Wright | Jaret Wright | Doug Drabek | | 699 | 757 | -58 |
| 1997-09-13 | vs CLE | 148 | W 7-6 | 73-75 | 2 | 32,306 | Mike Sirotka | Orel Hershiser | Mike Sirotka | Orel Hershiser | Matt Karchner | 706 | 763 | -57 |
| 1997-09-14 | vs CLE | 149 | L 3-8 | 73-76 | 2 | 32,485 | Jaime Navarro | Bartolo Colon | Paul Shuey | Jeff Darwin | | 709 | 771 | -62 |
| 1997-09-15 | @ MIL | 150 | L 10-11 | 73-77 | 3 | 11,013 | Scott Eyre | Cal Eldred | Cal Eldred | Scott Eyre | Doug Jones | 719 | 782 | -63 |
| 1997-09-17 | @ KCA | 151 | W 8-4 | 74-77 | 3 | 11,806 | James Baldwin | Jose Rosado | James Baldwin | Scott Service | Keith Foulke | 727 | 786 | -59 |
| 1997-09-18 | @ KCA | 152 | W 9-2 | 75-77 | 2 | 12,698 | Doug Drabek | Jim Pittsley | Doug Drabek | Jim Pittsley | | 736 | 788 | -52 |
| 1997-09-19 | @ BOS | 153 | W 5-4 | 76-77 | 2 | 27,647 | Mike Sirotka | Butch Henry | Keith Foulke | Derek Lowe | Tony Castillo | 741 | 792 | -51 |
| 1997-09-20 | @ BOS | 154 | W 6-4 | 77-77 | 2 | 30,549 | Jaime Navarro | Bret Saberhagen | Chuck McElroy | Steve Avery | Tony Castillo | 747 | 796 | -49 |
| 1997-09-21 | @ BOS | 155 | L 2-5 | 77-78 | 2 | 27,229 | Scott Eyre | Aaron Sele | Jim Corsi | Tom Fordham | Tom Gordon | 749 | 801 | -52 |
| 1997-09-23 | vs MIN | 156 | L 3-5 | 77-79 | 2 | 14,820 | Jason Bere | Bob Tewksbury | Bob Tewksbury | Jason Bere | Rick Aguilera | 752 | 806 | -54 |
| 1997-09-24 | vs MIN | 157 | L 2-7 | 77-80 | 2 | 16,195 | James Baldwin | Frankie Rodriguez | Frankie Rodriguez | James Baldwin | Rick Aguilera | 754 | 813 | -59 |
| 1997-09-25 | vs MIN | 158 | W 10-5 | 78-80 | 2 | 15,508 | Doug Drabek | LaTroy Hawkins | Doug Drabek | LaTroy Hawkins | | 764 | 818 | -54 |
| 1997-09-26 | vs KCA | 159 | W 7-2 | 79-80 | 2 | 17,167 | Mike Sirotka | Kevin Appier | Mike Sirotka | Kevin Appier | | 771 | 820 | -49 |
| 1997-09-27 | vs KCA | 160 | L 4-10 | 79-81 | 2 | 27,824 | Jaime Navarro | Ricky Bones | Ricky Bones | Jaime Navarro | Gregg Olson | 775 | 830 | -55 |
| 1997-09-28 | vs KCA | 161 | W 4-3 | 80-81 | 2 | 24,062 | Scott Eyre | Jim Pittsley | Scott Eyre | Scott Service | Keith Foulke | 779 | 833 | -54 |