| 1997-04-01 | vs NYA | 1 | W 4-2 | 1-0 | 1 | 57,586 | Jeff Fassero | David Cone | Jeff Fassero | David Cone | Norm Charlton | 4 | 2 | 2 |
| 1997-04-02 | vs NYA | 2 | L 2-16 | 1-1 | 2 | 30,951 | Scott Sanders | Andy Pettitte | Andy Pettitte | Scott Sanders | | 6 | 18 | -12 |
| 1997-04-04 | vs BOS | 3 | L 5-10 | 1-2 | 4 | 40,176 | Bob Wolcott | Aaron Sele | Aaron Sele | Bob Wolcott | Butch Henry | 11 | 28 | -17 |
| 1997-04-05 | vs BOS | 4 | L 6-8 | 1-3 | 4 | 57,110 | Randy Johnson | Steve Avery | Ricky Trlicek | Norm Charlton | Heathcliff Slocumb | 17 | 36 | -19 |
| 1997-04-06 | vs BOS | 5 | W 8-7 | 2-3 | 4 | 33,450 | Jeff Fassero | John Wasdin | Norm Charlton | Ricky Trlicek | | 25 | 43 | -18 |
| 1997-04-07 | vs CLE | 6 | L 3-8 | 2-4 | 4 | 22,012 | Scott Sanders | Charles Nagy | Charles Nagy | Scott Sanders | | 28 | 51 | -23 |
| 1997-04-08 | vs CLE | 7 | W 14-8 | 3-4 | 3 | 24,348 | Dennis Martinez | Orel Hershiser | Edwin Hurtado | Albie Lopez | | 42 | 59 | -17 |
| 1997-04-09 | vs CLE | 8 | W 11-1 | 4-4 | 2 | 28,302 | Bob Wolcott | Bartolo Colon | Bob Wolcott | Bartolo Colon | | 53 | 60 | -7 |
| 1997-04-11 | @ BOS | 9 | W 5-3 | 5-4 | 2 | 34,210 | Randy Johnson | Steve Avery | Randy Johnson | Steve Avery | Norm Charlton | 58 | 63 | -5 |
| 1997-04-12 | @ BOS | 10 | W 5-1 | 6-4 | 2 | 15,358 | Jeff Fassero | John Wasdin | Jeff Fassero | Jim Corsi | | 63 | 64 | -1 |
| 1997-04-13 | @ BOS | 11 | L 1-7 | 6-5 | 2 | 30,300 | Scott Sanders | Tom Gordon | Tom Gordon | Scott Sanders | | 64 | 71 | -7 |
| 1997-04-14 | @ CLE | 12 | W 6-1 | 7-5 | 2 | 41,184 | Dennis Martinez | Charles Nagy | Dennis Martinez | Charles Nagy | | 70 | 72 | -2 |
| 1997-04-15 | @ CLE | 13 | W 8-4 | 8-5 | 1 | 40,118 | Bob Wolcott | Orel Hershiser | Bob Wells | Michael Jackson | Norm Charlton | 78 | 76 | 2 |
| 1997-04-16 | @ DET | 14 | W 7-3 | 9-5 | 1 | 8,090 | Randy Johnson | Omar Olivares | Randy Johnson | A.J. Sager | | 85 | 79 | 6 |
| 1997-04-17 | @ DET | 15 | W 8-6 | 10-5 | 1 | 8,973 | Jeff Fassero | Felipe Lira | Jeff Fassero | Jose Bautista | Norm Charlton | 93 | 85 | 8 |
| 1997-04-18 | vs MIN | 16 | L 3-10 | 10-6 | 1 | 33,574 | Scott Sanders | Frankie Rodriguez | Frankie Rodriguez | Scott Sanders | | 96 | 95 | 1 |
| 1997-04-19 | vs MIN | 17 | L 0-4 | 10-7 | 1 | 42,142 | Dennis Martinez | Bob Tewksbury | Bob Tewksbury | Dennis Martinez | | 96 | 99 | -3 |
| 1997-04-20 | vs MIN | 18 | W 10-6 | 11-7 | 1 | 34,678 | Bob Wolcott | Scott Aldred | Bob Wolcott | Todd Ritchie | Norm Charlton | 106 | 105 | 1 |
| 1997-04-21 | vs KCA | 19 | W 6-5 | 12-7 | 1 | 42,606 | Randy Johnson | Jose Rosado | Bobby Ayala | Brian Bevil | Norm Charlton | 112 | 110 | 2 |
| 1997-04-22 | vs KCA | 20 | W 7-2 | 13-7 | 1 | 21,764 | Jeff Fassero | Tim Belcher | Jeff Fassero | Tim Belcher | | 119 | 112 | 7 |
| 1997-04-23 | vs KCA | 21 | L 10-12 | 13-8 | 1 | 21,855 | Bob Wells | Jim Pittsley | Randy Veres | Edwin Hurtado | Hipolito Pichardo | 129 | 124 | 5 |
| 1997-04-25 | @ TOR | 22 | W 13-8 | 14-8 | 1 | 31,215 | Dennis Martinez | Roger Clemens | Bobby Ayala | Dan Plesac | | 142 | 132 | 10 |
| 1997-04-26 | @ TOR | 23 | L 3-4 | 14-9 | 1 | 31,420 | Bob Wolcott | Woody Williams | Paul Quantrill | Derek Lowe | | 145 | 136 | 9 |
| 1997-04-27 | @ TOR | 24 | W 2-1 | 15-9 | 1 | 32,160 | Randy Johnson | Robert Person | Randy Johnson | Robert Person | Norm Charlton | 147 | 137 | 10 |
| 1997-04-28 | @ NYA | 25 | L 5-6 | 15-10 | 1 | 20,054 | Jeff Fassero | Kenny Rogers | Jeff Nelson | Bobby Ayala | Mariano Rivera | 152 | 143 | 9 |
| 1997-04-29 | @ NYA | 26 | W 7-5 | 16-10 | 1 | 21,955 | Jamie Moyer | Ramiro Mendoza | Greg McCarthy | Jim Mecir | | 159 | 148 | 11 |
| 1997-04-30 | @ NYA | 27 | L 2-3 | 16-11 | 1 | 25,708 | Dennis Martinez | David Wells | David Wells | Dennis Martinez | Mariano Rivera | 161 | 151 | 10 |
| 1997-05-02 | vs MIL | 28 | W 8-1 | 17-11 | 1 | 37,430 | Randy Johnson | Jeff D'Amico | Randy Johnson | Jeff D'Amico | | 169 | 152 | 17 |
| 1997-05-03 | vs MIL | 29 | L 4-17 | 17-12 | 1 | 50,005 | Jeff Fassero | Jose Mercedes | Bryce Florie | Jeff Fassero | | 173 | 169 | 4 |
| 1997-05-04 | vs MIL | 30 | W 9-0 | 18-12 | 1 | 38,540 | Jamie Moyer | Cal Eldred | Jamie Moyer | Cal Eldred | | 182 | 169 | 13 |
| 1997-05-06 | @ CHA | 31 | W 7-6 | 19-12 | 1 | 19,136 | Dennis Martinez | Wilson Alvarez | Bobby Ayala | Tony Castillo | Norm Charlton | 189 | 175 | 14 |
| 1997-05-08 | @ BAL | 32 | L 3-13 | 19-13 | 1 | 45,026 | Randy Johnson | Mike Mussina | Mike Mussina | Randy Johnson | | 192 | 188 | 4 |
| 1997-05-09 | @ BAL | 33 | W 8-2 | 20-13 | 1 | 47,257 | Jamie Moyer | Rocky Coppinger | Jamie Moyer | Rocky Coppinger | | 200 | 190 | 10 |
| 1997-05-10 | @ BAL | 34 | W 3-2 | 21-13 | 1 | 47,340 | Jeff Fassero | Scott Kamieniecki | Norm Charlton | Randy Myers | | 203 | 192 | 11 |
| 1997-05-11 | @ BAL | 35 | L 5-9 | 21-14 | 1 | 47,451 | Dennis Martinez | Scott Erickson | Scott Erickson | Dennis Martinez | | 208 | 201 | 7 |
| 1997-05-12 | @ MIL | 36 | L 8-9 | 21-15 | 2 | 10,587 | Bob Wolcott | Jeff D'Amico | Jeff D'Amico | Bob Wolcott | Doug Jones | 216 | 210 | 6 |
| 1997-05-13 | @ MIL | 37 | W 2-1 | 22-15 | 1 | 13,011 | Randy Johnson | Jose Mercedes | Randy Johnson | Mike Fetters | Norm Charlton | 218 | 211 | 7 |
| 1997-05-14 | vs CHA | 38 | W 9-7 | 23-15 | 1 | 31,374 | Jamie Moyer | Jaime Navarro | Jamie Moyer | Jaime Navarro | Norm Charlton | 227 | 218 | 9 |
| 1997-05-15 | vs CHA | 39 | L 3-4 | 23-16 | 1 | 29,225 | Jeff Fassero | Doug Drabek | Bill Simas | Norm Charlton | Roberto Hernandez | 230 | 222 | 8 |
| 1997-05-16 | vs BAL | 40 | L 3-6 | 23-17 | 2 | 39,455 | Dennis Martinez | Scott Erickson | Scott Erickson | Dennis Martinez | | 233 | 228 | 5 |
| 1997-05-17 | vs BAL | 41 | L 3-4 | 23-18 | 2 | 57,304 | Scott Sanders | Jimmy Key | Jimmy Key | Scott Sanders | Armando Benitez | 236 | 232 | 4 |
| 1997-05-18 | vs BAL | 42 | L 7-8 | 23-19 | 2 | 57,432 | Randy Johnson | Mike Mussina | Jesse Orosco | Norm Charlton | Armando Benitez | 243 | 240 | 3 |
| 1997-05-19 | @ ANA | 43 | W 13-4 | 24-19 | 2 | 17,279 | Jamie Moyer | Mark Langston | Jamie Moyer | Mark Langston | | 256 | 244 | 12 |
| 1997-05-20 | @ ANA | 44 | L 9-11 | 24-20 | 2 | 17,492 | Jeff Fassero | Jason Dickson | Rich DeLucia | Josias Manzanillo | Troy Percival | 265 | 255 | 10 |
| 1997-05-21 | @ ANA | 45 | L 3-18 | 24-21 | 3 | 20,295 | Dennis Martinez | Chuck Finley | Chuck Finley | Dennis Martinez | | 268 | 273 | -5 |
| 1997-05-23 | @ KCA | 46 | W 8-4 | 25-21 | 3 | 21,042 | Randy Johnson | Tim Belcher | Randy Johnson | Tim Belcher | | 276 | 277 | -1 |
| 1997-05-24 | @ KCA | 47 | L 5-11 | 25-22 | 3 | 28,016 | Jamie Moyer | Jim Pittsley | Randy Veres | Jamie Moyer | Hipolito Pichardo | 281 | 288 | -7 |
| 1997-05-25 | @ KCA | 48 | L 3-4 | 25-23 | 3 | 22,733 | Jeff Fassero | Glendon Rusch | Jamie Walker | Bobby Ayala | | 284 | 292 | -8 |
| 1997-05-26 | @ MIN | 49 | W 13-8 | 26-23 | 3 | 14,134 | Scott Sanders | Scott Aldred | Scott Sanders | Scott Aldred | | 297 | 300 | -3 |
| 1997-05-27 | @ MIN | 50 | L 10-11 | 26-24 | 3 | 14,629 | Derek Lowe | Kevin Jarvis | Rick Aguilera | Norm Charlton | | 307 | 311 | -4 |
| 1997-05-28 | vs TEX | 51 | W 5-0 | 27-24 | 3 | 26,016 | Randy Johnson | Darren Oliver | Randy Johnson | Darren Oliver | | 312 | 311 | 1 |
| 1997-05-29 | vs TEX | 52 | L 2-8 | 27-25 | 3 | 28,722 | Jamie Moyer | Ken Hill | Ken Hill | Jamie Moyer | | 314 | 319 | -5 |
| 1997-05-30 | vs DET | 53 | L 2-5 | 27-26 | 3 | 32,305 | Jeff Fassero | Felipe Lira | Felipe Lira | Jeff Fassero | Todd Jones | 316 | 324 | -8 |
| 1997-05-31 | vs DET | 54 | L 2-4 | 27-27 | 3 | 57,118 | Bob Wolcott | Omar Olivares | Omar Olivares | Bob Wolcott | Todd Jones | 318 | 328 | -10 |
| 1997-06-01 | vs DET | 55 | W 4-1 | 28-27 | 3 | 39,841 | Derek Lowe | Justin Thompson | Scott Sanders | Justin Thompson | Bobby Ayala | 322 | 329 | -7 |
| 1997-06-02 | vs TOR | 56 | W 3-0 | 29-27 | 3 | 40,312 | Randy Johnson | Luis Andujar | Randy Johnson | Luis Andujar | | 325 | 329 | -4 |
| 1997-06-03 | vs TOR | 57 | W 6-3 | 30-27 | 2 | 28,786 | Jamie Moyer | Woody Williams | Jamie Moyer | Woody Williams | | 331 | 332 | -1 |
| 1997-06-05 | @ DET | 58 | W 14-6 | 31-27 | 3 | 12,572 | Jeff Fassero | Felipe Lira | Jeff Fassero | Felipe Lira | | 345 | 338 | 7 |
| 1997-06-06 | @ DET | 59 | W 6-3 | 32-27 | 2 | 25,547 | Derek Lowe | Omar Olivares | Derek Lowe | Omar Olivares | Bobby Ayala | 351 | 341 | 10 |
| 1997-06-07 | @ DET | 60 | L 1-3 | 32-28 | 2 | 18,896 | Bob Wolcott | Justin Thompson | Justin Thompson | Bob Wolcott | Todd Jones | 352 | 344 | 8 |
| 1997-06-08 | @ DET | 61 | W 2-0 | 33-28 | 1 | 20,287 | Randy Johnson | Brian Moehler | Randy Johnson | Brian Moehler | Bobby Ayala | 354 | 344 | 10 |
| 1997-06-10 | @ TOR | 62 | L 3-8 | 33-29 | 2 | 33,124 | Jamie Moyer | Pat Hentgen | Pat Hentgen | Scott Sanders | | 357 | 352 | 5 |
| 1997-06-11 | @ TOR | 63 | W 5-1 | 34-29 | 1 | 41,099 | Jeff Fassero | Roger Clemens | Jeff Fassero | Roger Clemens | | 362 | 353 | 9 |
| 1997-06-12 | vs COL | 64 | W 12-11 | 35-29 | 1 | 37,948 | Derek Lowe | Darren Holmes | Bob Wells | Mike Munoz | Bobby Ayala | 374 | 364 | 10 |
| 1997-06-13 | vs COL | 65 | W 6-1 | 36-29 | 1 | 55,980 | Randy Johnson | Jamey Wright | Randy Johnson | Jamey Wright | | 380 | 365 | 15 |
| 1997-06-14 | vs LAN | 66 | W 9-8 | 37-29 | 1 | 57,345 | Bob Wolcott | Ramon Martinez | Bobby Ayala | Antonio Osuna | | 389 | 373 | 16 |
| 1997-06-15 | vs LAN | 67 | W 8-2 | 38-29 | 1 | 57,114 | Jamie Moyer | Ismael Valdez | Jamie Moyer | Ismael Valdez | Scott Sanders | 397 | 375 | 22 |
| 1997-06-17 | @ SFN | 68 | L 3-4 | 38-30 | 1 | 40,024 | Jeff Fassero | Kirk Rueter | Kirk Rueter | Jeff Fassero | Rod Beck | 400 | 379 | 21 |
| 1997-06-18 | @ SFN | 69 | L 2-4 | 38-31 | 1 | 33,234 | Derek Lowe | Mark Gardner | Mark Gardner | Derek Lowe | Rod Beck | 402 | 383 | 19 |
| 1997-06-19 | @ TEX | 70 | W 2-1 | 39-31 | 1 | 45,572 | Randy Johnson | Ken Hill | Randy Johnson | Ken Hill | Bobby Ayala | 404 | 384 | 20 |
| 1997-06-20 | @ TEX | 71 | W 5-4 | 40-31 | 1 | 46,013 | Bob Wolcott | Bobby Witt | Bob Wolcott | Bobby Witt | Scott Sanders | 409 | 388 | 21 |
| 1997-06-21 | @ TEX | 72 | W 15-8 | 41-31 | 1 | 46,193 | Jamie Moyer | Julio Santana | Mike Maddux | Ed Vosberg | | 424 | 396 | 28 |
| 1997-06-22 | @ TEX | 73 | W 6-4 | 42-31 | 1 | 40,814 | Jeff Fassero | John Burkett | Jeff Fassero | John Burkett | Bobby Ayala | 430 | 400 | 30 |
| 1997-06-23 | vs OAK | 74 | W 6-5 | 43-31 | 1 | 27,857 | Derek Lowe | Dave Telgheder | Derek Lowe | Dave Telgheder | Norm Charlton | 436 | 405 | 31 |
| 1997-06-24 | vs OAK | 75 | L 1-4 | 43-32 | 1 | 34,801 | Randy Johnson | Steve Karsay | Steve Karsay | Randy Johnson | | 437 | 409 | 28 |
| 1997-06-25 | vs OAK | 76 | W 9-4 | 44-32 | 1 | 27,662 | Bob Wolcott | Don Wengert | Bob Wolcott | Don Wengert | | 446 | 413 | 33 |
| 1997-06-26 | vs ANA | 77 | W 6-3 | 45-32 | 1 | 31,248 | Jamie Moyer | Jason Dickson | Jamie Moyer | Jason Dickson | Norm Charlton | 452 | 416 | 36 |
| 1997-06-27 | vs ANA | 78 | W 8-1 | 46-32 | 1 | 32,247 | Jeff Fassero | Chuck Finley | Jeff Fassero | Chuck Finley | | 460 | 417 | 43 |
| 1997-06-28 | vs ANA | 79 | L 1-6 | 46-33 | 1 | 38,750 | Derek Lowe | Allen Watson | Allen Watson | Derek Lowe | | 461 | 423 | 38 |
| 1997-06-29 | vs ANA | 80 | W 3-2 | 47-33 | 1 | 42,760 | Randy Johnson | Dennis Springer | Bobby Ayala | Rich DeLucia | | 464 | 425 | 39 |
| 1997-06-30 | vs SFN | 81 | L 6-8 | 47-34 | 1 | 41,231 | Bob Wolcott | Keith Foulke | Rod Beck | Norm Charlton | Doug Henry | 470 | 433 | 37 |
| 1997-07-01 | vs SFN | 82 | W 15-4 | 48-34 | 1 | 48,313 | Jamie Moyer | William VanLandingham | Jamie Moyer | William VanLandingham | | 485 | 437 | 48 |
| 1997-07-02 | @ SDN | 83 | L 5-8 | 48-35 | 1 | 39,018 | Jeff Fassero | Joey Hamilton | Joey Hamilton | Jeff Fassero | | 490 | 445 | 45 |
| 1997-07-03 | @ SDN | 84 | L 8-10 | 48-36 | 1 | 46,483 | Derek Lowe | Sterling Hitchcock | Rich Batchelor | Greg McCarthy | Trevor Hoffman | 498 | 455 | 43 |
| 1997-07-04 | @ ANA | 85 | W 7-3 | 49-36 | 1 | 34,839 | Randy Johnson | Dennis Springer | Randy Johnson | Dennis Springer | | 505 | 458 | 47 |
| 1997-07-05 | @ ANA | 86 | L 4-5 | 49-37 | 1 | 26,301 | Jamie Moyer | Matt Perisho | Troy Percival | Norm Charlton | | 509 | 463 | 46 |
| 1997-07-06 | @ ANA | 87 | L 0-8 | 49-38 | 1 | 22,916 | Jeff Fassero | Chuck Finley | Chuck Finley | Jeff Fassero | | 509 | 471 | 38 |
| 1997-07-10 | vs TEX | 88 | W 12-9 | 50-38 | 1 | 32,851 | Jamie Moyer | Ken Hill | Jamie Moyer | Ken Hill | Norm Charlton | 521 | 480 | 41 |
| 1997-07-11 | vs TEX | 89 | W 8-7 | 51-38 | 1 | 39,739 | Jeff Fassero | Darren Oliver | Bobby Ayala | Xavier Hernandez | | 529 | 487 | 42 |
| 1997-07-12 | vs TEX | 90 | L 2-9 | 51-39 | 1 | 53,929 | Derek Lowe | John Burkett | John Burkett | Derek Lowe | | 531 | 496 | 35 |
| 1997-07-13 | vs TEX | 91 | L 2-4 | 51-40 | 1 | 47,467 | Randy Johnson | Bobby Witt | Danny Patterson | Bobby Ayala | John Wetteland | 533 | 500 | 33 |
| 1997-07-14 | @ OAK | 92 | W 6-2 | 52-40 | 1 | 16,357 | Bob Wolcott | Steve Wojciechowski | Bob Wolcott | Steve Wojciechowski | | 539 | 502 | 37 |
| 1997-07-15 | @ OAK | 93 | L 5-8 | 52-41 | 1 | 20,093 | Jamie Moyer | Brad Rigby | Mike Mohler | Jamie Moyer | Billy Taylor | 544 | 510 | 34 |
| 1997-07-16 | vs MIN | 94 | W 8-7 | 53-41 | 1 | 27,149 | Jeff Fassero | Rich Robertson | Scott Sanders | Rick Aguilera | | 552 | 517 | 35 |
| 1997-07-17 | vs MIN | 95 | L 7-9 | 53-42 | 1 | 32,325 | Edwin Hurtado | Bob Tewksbury | Rick Aguilera | Norm Charlton | Eddie Guardado | 559 | 526 | 33 |
| 1997-07-18 | vs KCA | 96 | W 5-4 | 54-42 | 1 | 34,968 | Randy Johnson | Ricky Bones | Randy Johnson | Ricky Bones | | 564 | 530 | 34 |
| 1997-07-19 | vs KCA | 97 | L 6-9 | 54-43 | 1 | 49,776 | Bob Wolcott | Glendon Rusch | Jeff Montgomery | Bobby Ayala | | 570 | 539 | 31 |
| 1997-07-20 | vs KCA | 98 | W 5-4 | 55-43 | 1 | 42,816 | Jamie Moyer | Kevin Appier | Jamie Moyer | Kevin Appier | Bob Wells | 575 | 543 | 32 |
| 1997-07-22 | @ CLE | 99 | L 2-6 | 55-44 | 1 | 42,951 | Jeff Fassero | Orel Hershiser | David Weathers | Jeff Fassero | Michael Jackson | 577 | 549 | 28 |
| 1997-07-23 | @ CLE | 100 | W 6-3 | 56-44 | 1 | 43,049 | Omar Olivares | Bartolo Colon | Omar Olivares | Bartolo Colon | Mark Holzemer | 583 | 552 | 31 |
| 1997-07-24 | @ CLE | 101 | W 11-1 | 57-44 | 1 | 42,984 | Randy Johnson | Terry Clark | Randy Johnson | Terry Clark | | 594 | 553 | 41 |
| 1997-07-25 | @ NYA | 102 | W 8-1 | 58-44 | 1 | 46,282 | Jamie Moyer | David Wells | Jamie Moyer | David Wells | | 602 | 554 | 48 |
| 1997-07-26 | @ NYA | 103 | W 9-7 | 59-44 | 1 | 54,664 | Bob Wolcott | Hideki Irabu | Bobby Ayala | Hideki Irabu | Norm Charlton | 611 | 561 | 50 |
| 1997-07-27 | @ NYA | 104 | W 3-2 | 60-44 | 1 | 49,550 | Jeff Fassero | Andy Pettitte | Jeff Fassero | Andy Pettitte | Bob Wells | 614 | 563 | 51 |
| 1997-07-29 | @ BOS | 105 | L 0-4 | 60-45 | 1 | 33,293 | Randy Johnson | Tim Wakefield | Tim Wakefield | Randy Johnson | | 614 | 567 | 47 |
| 1997-07-30 | @ BOS | 106 | L 7-8 | 60-46 | 1 | 33,056 | Omar Olivares | Jeff Suppan | Jim Corsi | Edwin Hurtado | | 621 | 575 | 46 |
| 1997-07-31 | @ MIL | 107 | L 1-2 | 60-47 | 1 | 20,823 | Jamie Moyer | Bryce Florie | Bob Wickman | Jamie Moyer | | 622 | 577 | 45 |
| 1997-08-01 | @ MIL | 108 | L 3-8 | 60-48 | 2 | 23,650 | Bob Wolcott | Cal Eldred | Cal Eldred | Bob Wolcott | | 625 | 585 | 40 |
| 1997-08-02 | @ MIL | 109 | W 14-4 | 61-48 | 2 | 43,215 | Jeff Fassero | Steve Woodard | Jeff Fassero | Steve Woodard | | 639 | 589 | 50 |
| 1997-08-03 | @ MIL | 110 | W 6-5 | 62-48 | 2 | 31,297 | Randy Johnson | Jose Mercedes | Randy Johnson | Alberto Reyes | Heathcliff Slocumb | 645 | 594 | 51 |
| 1997-08-05 | vs BAL | 111 | W 4-3 | 63-48 | 1 | 37,361 | Omar Olivares | Jimmy Key | Norm Charlton | Terry Mathews | | 649 | 597 | 52 |
| 1997-08-06 | vs BAL | 112 | L 3-4 | 63-49 | 2 | 38,871 | Jamie Moyer | Scott Erickson | Jesse Orosco | Heathcliff Slocumb | Randy Myers | 652 | 601 | 51 |
| 1997-08-07 | vs CHA | 113 | W 3-2 | 64-49 | 2 | 29,319 | Jeff Fassero | Scott Eyre | Jeff Fassero | Scott Eyre | Heathcliff Slocumb | 655 | 603 | 52 |
| 1997-08-08 | vs CHA | 114 | W 5-0 | 65-49 | 1 | 42,170 | Randy Johnson | Chris Clemons | Randy Johnson | Chris Clemons | | 660 | 603 | 57 |
| 1997-08-09 | vs CHA | 115 | L 2-5 | 65-50 | 2 | 45,063 | Ken Cloude | James Baldwin | James Baldwin | Ken Cloude | Matt Karchner | 662 | 608 | 54 |
| 1997-08-10 | vs CHA | 116 | L 1-2 | 65-51 | 2 | 38,357 | Omar Olivares | Doug Drabek | Doug Drabek | Omar Olivares | Matt Karchner | 663 | 610 | 53 |
| 1997-08-11 | vs MIL | 117 | W 11-1 | 66-51 | 2 | 51,016 | Jamie Moyer | Cal Eldred | Jamie Moyer | Cal Eldred | | 674 | 611 | 63 |
| 1997-08-12 | vs MIL | 118 | L 3-5 | 66-52 | 2 | 33,422 | Jeff Fassero | Steve Woodard | Steve Woodard | Jeff Fassero | Doug Jones | 677 | 616 | 61 |
| 1997-08-15 | @ BAL | 119 | L 3-4 | 67-53 | 2 | 0 | Randy Johnson | Scott Kamieniecki | Scott Kamieniecki | Randy Johnson | Randy Myers | 680 | 620 | 60 |
| 1997-08-15 | @ BAL | 120 | W 8-3 | 67-53 | 2 | 47,734 | Ken Cloude | Jimmy Key | Ken Cloude | Jimmy Key | | 688 | 623 | 65 |
| 1997-08-16 | @ CHA | 121 | W 11-6 | 68-53 | 1 | 40,223 | Jamie Moyer | Doug Drabek | Bobby Ayala | Doug Drabek | | 699 | 629 | 70 |
| 1997-08-17 | @ CHA | 122 | W 5-3 | 69-54 | 1 | 0 | Jeff Fassero | Jaime Navarro | Jeff Fassero | Jaime Navarro | | 704 | 632 | 72 |
| 1997-08-17 | @ CHA | 123 | L 2-4 | 69-54 | 1 | 35,571 | Omar Olivares | Mike Sirotka | Mike Sirotka | Omar Olivares | Matt Karchner | 706 | 636 | 70 |
| 1997-08-18 | @ CHA | 124 | L 0-5 | 69-55 | 1 | 31,441 | Felipe Lira | Scott Eyre | Scott Eyre | Felipe Lira | Keith Foulke | 706 | 641 | 65 |
| 1997-08-19 | vs CLE | 125 | L 5-7 | 69-56 | 2 | 33,645 | Ken Cloude | John Smiley | John Smiley | Ken Cloude | Jose Mesa | 711 | 648 | 63 |
| 1997-08-20 | vs CLE | 126 | W 1-0 | 70-56 | 1 | 32,546 | Randy Johnson | Charles Nagy | Randy Johnson | Charles Nagy | Heathcliff Slocumb | 712 | 648 | 64 |
| 1997-08-21 | vs CLE | 127 | W 7-6 | 71-56 | 1 | 30,395 | Jamie Moyer | Bartolo Colon | Jamie Moyer | Bartolo Colon | Heathcliff Slocumb | 719 | 654 | 65 |
| 1997-08-22 | vs NYA | 128 | W 9-5 | 72-56 | 1 | 57,351 | Jeff Fassero | Kenny Rogers | Jeff Fassero | Kenny Rogers | | 728 | 659 | 69 |
| 1997-08-23 | vs NYA | 129 | L 8-10 | 72-57 | 1 | 57,282 | Omar Olivares | Ramiro Mendoza | Mariano Rivera | Heathcliff Slocumb | Mike Stanton | 736 | 669 | 67 |
| 1997-08-24 | vs NYA | 130 | W 5-3 | 73-57 | 1 | 54,391 | Ken Cloude | David Wells | Bobby Ayala | David Wells | Mike Timlin | 741 | 672 | 69 |
| 1997-08-25 | vs BOS | 131 | L 8-9 | 73-58 | 1 | 29,939 | Bob Wolcott | Jeff Suppan | Joe Hudson | Heathcliff Slocumb | Tom Gordon | 749 | 681 | 68 |
| 1997-08-26 | vs BOS | 132 | W 8-2 | 74-58 | 1 | 32,287 | Jamie Moyer | Steve Avery | Jamie Moyer | Steve Avery | | 757 | 683 | 74 |
| 1997-08-27 | vs BOS | 133 | L 5-9 | 74-59 | 1 | 34,633 | Jeff Fassero | Bret Saberhagen | John Wasdin | Jeff Fassero | Tom Gordon | 762 | 692 | 70 |
| 1997-08-28 | @ COL | 134 | L 5-9 | 74-60 | 1 | 48,422 | Omar Olivares | Pedro Astacio | Pedro Astacio | Omar Olivares | | 767 | 701 | 66 |
| 1997-08-29 | @ COL | 135 | L 5-6 | 74-61 | 1 | 48,178 | Ken Cloude | Jamey Wright | Jerry DiPoto | Mike Timlin | | 772 | 707 | 65 |
| 1997-08-30 | @ LAN | 136 | L 2-11 | 74-62 | 1 | 53,638 | Bob Wolcott | Ramon Martinez | Ramon Martinez | Bob Wolcott | Darren Dreifort | 774 | 718 | 56 |
| 1997-08-31 | @ LAN | 137 | W 3-1 | 75-62 | 1 | 54,213 | Jamie Moyer | Tom Candiotti | Mike Timlin | Todd Worrell | Bobby Ayala | 777 | 719 | 58 |
| 1997-09-01 | vs SDN | 138 | W 9-6 | 76-62 | 1 | 31,882 | Jeff Fassero | Joey Hamilton | Jeff Fassero | Joey Hamilton | | 786 | 725 | 61 |
| 1997-09-03 | vs SDN | 139 | L 5-6 | 76-63 | 1 | 27,713 | Omar Olivares | Paul Menhart | Dario Veras | Mike Timlin | Trevor Hoffman | 791 | 731 | 60 |
| 1997-09-04 | @ MIN | 140 | W 9-6 | 77-63 | 1 | 10,234 | Ken Cloude | LaTroy Hawkins | Ken Cloude | LaTroy Hawkins | Heathcliff Slocumb | 800 | 737 | 63 |
| 1997-09-05 | @ MIN | 141 | W 10-6 | 78-63 | 1 | 20,152 | Jamie Moyer | Brad Radke | Jamie Moyer | Brad Radke | | 810 | 743 | 67 |
| 1997-09-06 | @ MIN | 142 | W 9-0 | 79-63 | 1 | 20,064 | Jeff Fassero | Rich Robertson | Jeff Fassero | Rich Robertson | | 819 | 743 | 76 |
| 1997-09-07 | @ MIN | 143 | L 6-9 | 79-64 | 1 | 12,291 | Felipe Lira | Bob Tewksbury | Bob Tewksbury | Felipe Lira | | 825 | 752 | 73 |
| 1997-09-08 | @ KCA | 144 | L 2-9 | 79-65 | 1 | 14,278 | Omar Olivares | Jim Pittsley | Jim Pittsley | Omar Olivares | | 827 | 761 | 66 |
| 1997-09-09 | @ KCA | 145 | W 4-3 | 80-65 | 1 | 14,913 | Ken Cloude | Tim Belcher | Mike Timlin | Hipolito Pichardo | Heathcliff Slocumb | 831 | 764 | 67 |
| 1997-09-10 | vs DET | 146 | W 10-0 | 81-65 | 1 | 22,967 | Jamie Moyer | Justin Thompson | Jamie Moyer | Justin Thompson | | 841 | 764 | 77 |
| 1997-09-11 | vs DET | 147 | L 1-3 | 81-66 | 1 | 25,141 | Jeff Fassero | Brian Moehler | Brian Moehler | Jeff Fassero | Todd Jones | 842 | 767 | 75 |
| 1997-09-12 | vs TOR | 148 | W 7-3 | 82-66 | 1 | 37,044 | Omar Olivares | Roger Clemens | Bobby Ayala | Roger Clemens | | 849 | 770 | 79 |
| 1997-09-13 | vs TOR | 149 | L 3-6 | 82-67 | 1 | 51,631 | Randy Johnson | Omar Daal | Kelvim Escobar | Bobby Ayala | | 852 | 776 | 76 |
| 1997-09-14 | vs TOR | 150 | W 3-2 | 83-67 | 1 | 45,477 | Jamie Moyer | Chris Carpenter | Mike Timlin | Bill Risley | Heathcliff Slocumb | 855 | 778 | 77 |
| 1997-09-15 | vs TOR | 151 | W 7-3 | 84-67 | 1 | 41,684 | Ken Cloude | Woody Williams | Ken Cloude | Woody Williams | Heathcliff Slocumb | 862 | 781 | 81 |
| 1997-09-17 | @ TEX | 152 | L 4-5 | 84-68 | 1 | 30,467 | Jeff Fassero | John Burkett | Danny Patterson | Heathcliff Slocumb | | 866 | 786 | 80 |
| 1997-09-18 | @ TEX | 153 | W 6-3 | 85-68 | 1 | 30,697 | Randy Johnson | Darren Oliver | Randy Johnson | Darren Oliver | Bobby Ayala | 872 | 789 | 83 |
| 1997-09-19 | @ OAK | 154 | W 9-4 | 86-68 | 1 | 16,373 | Jamie Moyer | Jimmy Haynes | Jamie Moyer | Jimmy Haynes | | 881 | 793 | 88 |
| 1997-09-20 | @ OAK | 155 | L 3-4 | 86-69 | 1 | 26,619 | Omar Olivares | Mike Oquist | Aaron Small | Felipe Lira | | 884 | 797 | 87 |
| 1997-09-21 | @ OAK | 156 | W 9-2 | 87-69 | 1 | 20,737 | Ken Cloude | Brad Rigby | Ken Cloude | Brad Rigby | | 893 | 799 | 94 |
| 1997-09-22 | @ OAK | 157 | W 4-2 | 88-69 | 1 | 11,275 | Jeff Fassero | Eric Ludwick | Jeff Fassero | Eric Ludwick | Heathcliff Slocumb | 897 | 801 | 96 |
| 1997-09-23 | vs ANA | 158 | W 4-3 | 89-69 | 1 | 52,884 | Randy Johnson | Allen Watson | Randy Johnson | Allen Watson | Heathcliff Slocumb | 901 | 804 | 97 |
| 1997-09-24 | vs ANA | 159 | L 3-9 | 89-70 | 1 | 41,975 | Felipe Lira | Ken Hill | Ken Hill | Felipe Lira | | 904 | 813 | 91 |
| 1997-09-26 | vs OAK | 160 | L 5-8 | 89-71 | 1 | 55,560 | Jamie Moyer | Mike Oquist | Mike Oquist | Jamie Moyer | T.J. Mathews | 909 | 821 | 88 |
| 1997-09-27 | vs OAK | 161 | W 9-3 | 90-71 | 1 | 50,443 | Omar Olivares | Brad Rigby | Randy Johnson | Brad Rigby | | 918 | 824 | 94 |
| 1997-09-28 | vs OAK | 162 | L 7-9 | 90-72 | 1 | 55,910 | Jeff Fassero | Dave Telgheder | Aaron Small | Norm Charlton | Billy Taylor | 925 | 833 | 92 |