| 1997-04-02 | vs CLE | 1 | L 7-9 | 0-1 | 4 | 41,235 | Ariel Prieto | Charles Nagy | Steve Kline | Don Wengert | Paul Shuey | 7 | 9 | -2 |
| 1997-04-03 | vs CLE | 2 | W 5-4 | 1-1 | 3 | 13,707 | Willie Adams | Orel Hershiser | Richie Lewis | Eric Plunk | Billy Taylor | 12 | 13 | -1 |
| 1997-04-04 | vs NYA | 3 | W 4-2 | 2-1 | 2 | 17,330 | Steve Karsay | David Wells | Mark Acre | David Weathers | Billy Taylor | 16 | 15 | 1 |
| 1997-04-05 | vs NYA | 4 | L 5-10 | 2-2 | 2 | 25,438 | Mike Mohler | Dwight Gooden | Dwight Gooden | Mike Mohler | Mariano Rivera | 21 | 25 | -4 |
| 1997-04-06 | vs NYA | 5 | W 3-0 | 3-2 | 1 | 22,124 | Dave Telgheder | David Cone | Mark Acre | Jeff Nelson | Billy Taylor | 24 | 25 | -1 |
| 1997-04-07 | vs BOS | 6 | W 6-2 | 4-2 | 1 | 8,482 | Ariel Prieto | Tom Gordon | Richie Lewis | Tom Gordon | Billy Taylor | 30 | 27 | 3 |
| 1997-04-08 | vs BOS | 7 | L 7-13 | 4-3 | 1 | 9,010 | Willie Adams | Tim Wakefield | Ricky Trlicek | Don Wengert | Butch Henry | 37 | 40 | -3 |
| 1997-04-09 | vs BOS | 8 | W 4-3 | 5-3 | 1 | 11,057 | Steve Karsay | Aaron Sele | Aaron Small | Ricky Trlicek | | 41 | 43 | -2 |
| 1997-04-11 | @ NYA | 9 | W 3-1 | 6-3 | 1 | 56,710 | Mike Mohler | David Cone | Aaron Small | Jeff Nelson | | 44 | 44 | 0 |
| 1997-04-13 | @ NYA | 10 | L 2-3 | 7-4 | 1 | 0 | Dave Telgheder | Andy Pettitte | Andy Pettitte | Dave Telgheder | Mariano Rivera | 46 | 47 | -1 |
| 1997-04-13 | @ NYA | 11 | W 7-4 | 7-4 | 1 | 32,098 | Ariel Prieto | Ramiro Mendoza | Ariel Prieto | Ramiro Mendoza | Billy Taylor | 53 | 51 | 2 |
| 1997-04-14 | @ BOS | 12 | L 1-10 | 7-5 | 1 | 18,166 | Willie Adams | Tim Wakefield | Tim Wakefield | Willie Adams | | 54 | 61 | -7 |
| 1997-04-15 | @ BOS | 13 | L 2-7 | 7-6 | 2 | 17,862 | Steve Karsay | Aaron Sele | Aaron Sele | Steve Karsay | | 56 | 68 | -12 |
| 1997-04-16 | @ TOR | 14 | L 3-4 | 7-7 | 3 | 26,139 | Mike Mohler | Robert Person | Tim Crabtree | Billy Taylor | | 59 | 72 | -13 |
| 1997-04-17 | @ TOR | 15 | L 4-5 | 7-8 | 3 | 25,625 | Ariel Prieto | Erik Hanson | Paul Quantrill | Buddy Groom | Mike Timlin | 63 | 77 | -14 |
| 1997-04-18 | @ DET | 16 | W 9-5 | 8-8 | 3 | 7,748 | Dave Telgheder | Doug Brocail | Buddy Groom | Mike Myers | | 72 | 82 | -10 |
| 1997-04-19 | @ DET | 17 | W 7-1 | 9-8 | 2 | 10,592 | Willie Adams | Justin Thompson | Willie Adams | Justin Thompson | | 79 | 83 | -4 |
| 1997-04-20 | @ DET | 18 | L 2-9 | 9-9 | 3 | 9,281 | Steve Karsay | Brian Moehler | Brian Moehler | Steve Karsay | | 81 | 92 | -11 |
| 1997-04-22 | vs MIN | 19 | L 3-5 | 9-10 | 3 | 8,192 | Mike Mohler | Brad Radke | Brad Radke | Mike Mohler | Rick Aguilera | 84 | 97 | -13 |
| 1997-04-23 | vs MIN | 20 | W 6-1 | 10-10 | 3 | 8,494 | Ariel Prieto | Rich Robertson | Ariel Prieto | Rich Robertson | Aaron Small | 90 | 98 | -8 |
| 1997-04-24 | vs MIN | 21 | W 12-11 | 11-10 | 3 | 9,044 | Dave Telgheder | Frankie Rodriguez | Don Wengert | Rick Aguilera | | 102 | 109 | -7 |
| 1997-04-25 | vs KCA | 22 | L 3-10 | 11-11 | 4 | 10,768 | Willie Adams | Kevin Appier | Kevin Appier | Willie Adams | | 105 | 119 | -14 |
| 1997-04-26 | vs KCA | 23 | W 7-6 | 12-11 | 3 | 21,097 | Steve Karsay | Jose Rosado | Aaron Small | Mitch Williams | | 112 | 125 | -13 |
| 1997-04-27 | vs KCA | 24 | L 1-7 | 12-12 | 4 | 16,294 | Mike Mohler | Tim Belcher | Tim Belcher | Mike Mohler | | 113 | 132 | -19 |
| 1997-04-29 | @ CLE | 25 | L 4-10 | 12-13 | 4 | 40,421 | Ariel Prieto | Charles Nagy | Charles Nagy | Ariel Prieto | Michael Jackson | 117 | 142 | -25 |
| 1997-04-30 | @ CLE | 26 | W 11-9 | 13-13 | 4 | 40,463 | Dave Telgheder | Orel Hershiser | Billy Taylor | Jose Mesa | Don Wengert | 128 | 151 | -23 |
| 1997-05-01 | @ CLE | 27 | L 1-7 | 13-14 | 4 | 42,398 | Willie Adams | Jack McDowell | Jack McDowell | Willie Adams | | 129 | 158 | -29 |
| 1997-05-02 | @ BAL | 28 | L 1-7 | 13-15 | 4 | 46,181 | Steve Karsay | Jimmy Key | Jimmy Key | Steve Karsay | | 130 | 165 | -35 |
| 1997-05-03 | @ BAL | 29 | W 4-3 | 14-15 | 4 | 45,750 | Mike Mohler | Mike Mussina | Aaron Small | Randy Myers | Billy Taylor | 134 | 168 | -34 |
| 1997-05-04 | @ BAL | 30 | L 0-11 | 14-16 | 4 | 47,001 | Ariel Prieto | Rocky Coppinger | Rocky Coppinger | Ariel Prieto | Mike Johnson | 134 | 179 | -45 |
| 1997-05-05 | @ MIL | 31 | L 7-11 | 14-17 | 4 | 7,762 | Dave Telgheder | Scott Karl | Scott Karl | Dave Telgheder | | 141 | 190 | -49 |
| 1997-05-06 | @ MIL | 32 | W 6-5 | 15-17 | 4 | 8,015 | Willie Adams | Ben McDonald | Willie Adams | Bryce Florie | Billy Taylor | 147 | 195 | -48 |
| 1997-05-07 | @ MIL | 33 | L 0-1 | 15-18 | 4 | 10,044 | Steve Karsay | Jeff D'Amico | Mike Fetters | Steve Montgomery | Doug Jones | 147 | 196 | -49 |
| 1997-05-08 | @ CHA | 34 | L 6-10 | 15-19 | 4 | 16,627 | Mike Mohler | James Baldwin | James Baldwin | Mike Mohler | | 153 | 206 | -53 |
| 1997-05-09 | @ CHA | 35 | L 2-3 | 15-20 | 4 | 16,295 | Ariel Prieto | Jaime Navarro | Roberto Hernandez | Aaron Small | | 155 | 209 | -54 |
| 1997-05-10 | @ CHA | 36 | L 8-9 | 15-21 | 4 | 28,816 | Dave Telgheder | Doug Drabek | Al Levine | Billy Taylor | | 163 | 218 | -55 |
| 1997-05-11 | @ CHA | 37 | L 5-8 | 15-22 | 4 | 17,518 | Willie Adams | Wilson Alvarez | Wilson Alvarez | Willie Adams | Roberto Hernandez | 168 | 226 | -58 |
| 1997-05-12 | vs BAL | 38 | L 1-5 | 15-23 | 4 | 11,352 | Steve Karsay | Jimmy Key | Jimmy Key | Steve Karsay | Armando Benitez | 169 | 231 | -62 |
| 1997-05-13 | vs BAL | 39 | L 3-7 | 15-24 | 4 | 14,854 | Mike Mohler | Mike Mussina | Mike Mussina | Mike Mohler | | 172 | 238 | -66 |
| 1997-05-14 | vs MIL | 40 | W 7-4 | 16-24 | 4 | 6,319 | Ariel Prieto | Cal Eldred | Ariel Prieto | Cal Eldred | | 179 | 242 | -63 |
| 1997-05-15 | vs MIL | 41 | W 6-5 | 17-24 | 4 | 6,765 | Dave Telgheder | Scott Karl | Don Wengert | Bob Wickman | Billy Taylor | 185 | 247 | -62 |
| 1997-05-16 | vs CHA | 42 | L 2-6 | 17-25 | 4 | 14,237 | Willie Adams | Wilson Alvarez | Wilson Alvarez | Willie Adams | Roberto Hernandez | 187 | 253 | -66 |
| 1997-05-17 | vs CHA | 43 | L 6-7 | 17-26 | 4 | 20,140 | Steve Karsay | Danny Darwin | Danny Darwin | Steve Karsay | Roberto Hernandez | 193 | 260 | -67 |
| 1997-05-18 | vs CHA | 44 | L 4-10 | 17-27 | 4 | 45,227 | Mike Mohler | James Baldwin | James Baldwin | Mike Mohler | | 197 | 270 | -73 |
| 1997-05-20 | @ TEX | 45 | L 3-8 | 17-28 | 4 | 29,745 | Ariel Prieto | Bobby Witt | Bobby Witt | Ariel Prieto | | 200 | 278 | -78 |
| 1997-05-21 | @ TEX | 46 | W 7-3 | 18-28 | 4 | 42,312 | Dave Telgheder | Julio Santana | Dave Telgheder | Julio Santana | | 207 | 281 | -74 |
| 1997-05-22 | @ TEX | 47 | L 7-10 | 18-29 | 4 | 36,204 | Willie Adams | John Burkett | John Burkett | Mike Oquist | John Wetteland | 214 | 291 | -77 |
| 1997-05-23 | @ MIN | 48 | W 8-4 | 19-29 | 4 | 36,568 | Steve Karsay | Brad Radke | Steve Karsay | Brad Radke | Billy Taylor | 222 | 295 | -73 |
| 1997-05-24 | @ MIN | 49 | L 4-7 | 19-30 | 4 | 35,745 | Mike Mohler | Rich Robertson | Rich Robertson | Mike Mohler | Rick Aguilera | 226 | 302 | -76 |
| 1997-05-25 | @ MIN | 50 | L 6-7 | 19-31 | 4 | 37,408 | Ariel Prieto | Bob Tewksbury | Rick Aguilera | Billy Taylor | | 232 | 309 | -77 |
| 1997-05-26 | @ KCA | 51 | W 2-1 | 20-31 | 4 | 31,300 | Dave Telgheder | Kevin Appier | Willie Adams | Mike Williams | Aaron Small | 234 | 310 | -76 |
| 1997-05-27 | @ KCA | 52 | W 8-6 | 21-31 | 4 | 11,886 | Mike Oquist | Jose Rosado | Billy Taylor | Hipolito Pichardo | Dane Johnson | 242 | 316 | -74 |
| 1997-05-28 | vs ANA | 53 | L 10-14 | 21-32 | 4 | 8,148 | Steve Karsay | Dennis Springer | Troy Percival | Mike Mohler | | 252 | 330 | -78 |
| 1997-05-29 | vs ANA | 54 | L 1-7 | 21-33 | 4 | 10,335 | Don Wengert | Allen Watson | Allen Watson | Don Wengert | | 253 | 337 | -84 |
| 1997-05-30 | vs TOR | 55 | W 12-7 | 22-33 | 4 | 11,004 | Ariel Prieto | Pat Hentgen | Ariel Prieto | Pat Hentgen | | 265 | 344 | -79 |
| 1997-05-31 | vs TOR | 56 | L 3-13 | 22-34 | 4 | 15,027 | Dave Telgheder | Roger Clemens | Roger Clemens | Dave Telgheder | | 268 | 357 | -89 |
| 1997-06-01 | vs TOR | 57 | W 8-2 | 23-34 | 4 | 21,127 | Mike Oquist | Robert Person | Mike Oquist | Robert Person | | 276 | 359 | -83 |
| 1997-06-02 | vs DET | 58 | L 7-8 | 23-35 | 4 | 6,480 | Steve Karsay | Brian Moehler | Brian Moehler | Steve Karsay | Doug Brocail | 283 | 367 | -84 |
| 1997-06-03 | vs DET | 59 | W 9-8 | 24-35 | 4 | 10,134 | Don Wengert | Willie Blair | Aaron Small | Mike Myers | Dane Johnson | 292 | 375 | -83 |
| 1997-06-05 | @ TOR | 60 | W 4-3 | 25-35 | 4 | 30,189 | Ariel Prieto | Pat Hentgen | Carlos Reyes | Pat Hentgen | Billy Taylor | 296 | 378 | -82 |
| 1997-06-06 | @ TOR | 61 | L 1-4 | 25-36 | 4 | 32,208 | Mike Oquist | Roger Clemens | Roger Clemens | Mike Oquist | Paul Quantrill | 297 | 382 | -85 |
| 1997-06-07 | @ TOR | 62 | L 1-3 | 25-37 | 4 | 28,490 | Steve Karsay | Robert Person | Robert Person | Steve Karsay | Paul Quantrill | 298 | 385 | -87 |
| 1997-06-08 | @ TOR | 63 | W 7-5 | 26-37 | 4 | 29,404 | Don Wengert | Luis Andujar | Don Wengert | Luis Andujar | Billy Taylor | 305 | 390 | -85 |
| 1997-06-10 | @ DET | 64 | L 4-6 | 26-38 | 4 | 10,019 | Ariel Prieto | Willie Blair | Willie Blair | Ariel Prieto | Todd Jones | 309 | 396 | -87 |
| 1997-06-11 | @ DET | 65 | L 2-4 | 26-39 | 4 | 11,534 | Mike Oquist | Felipe Lira | Doug Brocail | Aaron Small | Todd Jones | 311 | 400 | -89 |
| 1997-06-12 | vs LAN | 66 | W 5-4 | 27-39 | 4 | 28,201 | Dave Telgheder | Hideo Nomo | Dave Telgheder | Hideo Nomo | Billy Taylor | 316 | 404 | -88 |
| 1997-06-13 | vs LAN | 67 | L 4-6 | 27-40 | 4 | 28,235 | Steve Karsay | Pedro Astacio | Darren Hall | Aaron Small | Todd Worrell | 320 | 410 | -90 |
| 1997-06-14 | vs COL | 68 | L 1-7 | 27-41 | 4 | 25,139 | Don Wengert | Roger Bailey | Roger Bailey | Don Wengert | | 321 | 417 | -96 |
| 1997-06-15 | vs COL | 69 | W 5-2 | 28-41 | 4 | 24,333 | Ariel Prieto | Kevin Ritz | Ariel Prieto | Kevin Ritz | Billy Taylor | 326 | 419 | -93 |
| 1997-06-17 | @ SDN | 70 | W 10-3 | 29-41 | 4 | 22,816 | Mike Oquist | Joey Hamilton | Dane Johnson | Pete Smith | Aaron Small | 336 | 422 | -86 |
| 1997-06-18 | @ SDN | 71 | W 11-9 | 30-41 | 4 | 19,908 | Dave Telgheder | Will Cunnane | Carlos Reyes | Doug Bochtler | Buddy Groom | 347 | 431 | -84 |
| 1997-06-19 | @ ANA | 72 | L 3-4 | 30-42 | 4 | 17,034 | Steve Karsay | Matt Perisho | Mike James | Billy Taylor | | 350 | 435 | -85 |
| 1997-06-20 | @ ANA | 73 | L 2-5 | 30-43 | 4 | 19,503 | Don Wengert | Kevin Gross | Kevin Gross | Don Wengert | Troy Percival | 352 | 440 | -88 |
| 1997-06-21 | @ ANA | 74 | L 3-5 | 30-44 | 4 | 24,481 | Ariel Prieto | Jason Dickson | Rich DeLucia | Ariel Prieto | Troy Percival | 355 | 445 | -90 |
| 1997-06-22 | @ ANA | 75 | L 6-7 | 30-45 | 4 | 23,389 | Mike Oquist | Chuck Finley | Pep Harris | Aaron Small | Troy Percival | 361 | 452 | -91 |
| 1997-06-23 | @ SEA | 76 | L 5-6 | 30-46 | 4 | 27,857 | Dave Telgheder | Derek Lowe | Derek Lowe | Dave Telgheder | Norm Charlton | 366 | 458 | -92 |
| 1997-06-24 | @ SEA | 77 | W 4-1 | 31-46 | 4 | 34,801 | Steve Karsay | Randy Johnson | Steve Karsay | Randy Johnson | | 370 | 459 | -89 |
| 1997-06-25 | @ SEA | 78 | L 4-9 | 31-47 | 4 | 27,662 | Don Wengert | Bob Wolcott | Bob Wolcott | Don Wengert | | 374 | 468 | -94 |
| 1997-06-26 | vs TEX | 79 | W 6-3 | 32-47 | 4 | 8,350 | Ariel Prieto | Julio Santana | Ariel Prieto | Julio Santana | Billy Taylor | 380 | 471 | -91 |
| 1997-06-27 | vs TEX | 80 | W 7-4 | 33-47 | 4 | 12,046 | Mike Oquist | John Burkett | Mike Oquist | John Burkett | Billy Taylor | 387 | 475 | -88 |
| 1997-06-28 | vs TEX | 81 | L 0-2 | 33-48 | 4 | 35,188 | Brad Rigby | Darren Oliver | Darren Oliver | Brad Rigby | John Wetteland | 387 | 477 | -90 |
| 1997-06-29 | vs TEX | 82 | W 7-5 | 34-48 | 4 | 13,254 | Steve Karsay | Ken Hill | Carlos Reyes | Xavier Hernandez | Buddy Groom | 394 | 482 | -88 |
| 1997-06-30 | vs SDN | 83 | L 6-15 | 34-49 | 4 | 15,274 | Don Wengert | Andy Ashby | Andy Ashby | Don Wengert | | 400 | 497 | -97 |
| 1997-07-01 | vs SDN | 84 | W 8-6 | 35-49 | 4 | 16,232 | Ariel Prieto | Sean Bergman | Aaron Small | Doug Bochtler | | 408 | 503 | -95 |
| 1997-07-02 | @ SFN | 85 | W 8-1 | 36-49 | 4 | 26,506 | Mike Oquist | Kirk Rueter | Dane Johnson | Kirk Rueter | Buddy Groom | 416 | 504 | -88 |
| 1997-07-03 | @ SFN | 86 | L 4-6 | 36-50 | 4 | 47,719 | Brad Rigby | Doug Creek | Doug Creek | Brad Rigby | Rod Beck | 420 | 510 | -90 |
| 1997-07-04 | @ TEX | 87 | L 6-7 | 36-51 | 4 | 46,934 | Steve Karsay | Ken Hill | Ken Hill | Steve Karsay | John Wetteland | 426 | 517 | -91 |
| 1997-07-05 | @ TEX | 88 | L 1-8 | 36-52 | 4 | 43,612 | Don Wengert | Bobby Witt | Bobby Witt | Don Wengert | | 427 | 525 | -98 |
| 1997-07-06 | @ TEX | 89 | W 9-8 | 37-52 | 4 | 38,361 | Ariel Prieto | Julio Santana | Dane Johnson | Matt Whiteside | Billy Taylor | 436 | 533 | -97 |
| 1997-07-10 | vs ANA | 90 | L 4-8 | 37-53 | 4 | 10,827 | Brad Rigby | Allen Watson | Allen Watson | Brad Rigby | Rich DeLucia | 440 | 541 | -101 |
| 1997-07-11 | vs ANA | 91 | L 4-14 | 37-54 | 4 | 12,586 | Steve Karsay | Jason Dickson | Jason Dickson | Steve Karsay | | 444 | 555 | -111 |
| 1997-07-12 | vs ANA | 92 | L 3-6 | 37-55 | 4 | 22,093 | Ariel Prieto | Chuck Finley | Chuck Finley | Ariel Prieto | Troy Percival | 447 | 561 | -114 |
| 1997-07-13 | vs ANA | 93 | L 3-5 | 37-56 | 4 | 15,164 | Mike Oquist | Dennis Springer | Shigetoshi Hasegawa | Mike Oquist | Troy Percival | 450 | 566 | -116 |
| 1997-07-14 | vs SEA | 94 | L 2-6 | 37-57 | 4 | 16,357 | Steve Wojciechowski | Bob Wolcott | Bob Wolcott | Steve Wojciechowski | | 452 | 572 | -120 |
| 1997-07-15 | vs SEA | 95 | W 8-5 | 38-57 | 4 | 20,093 | Brad Rigby | Jamie Moyer | Mike Mohler | Jamie Moyer | Billy Taylor | 460 | 577 | -117 |
| 1997-07-16 | vs KCA | 96 | W 11-3 | 39-57 | 4 | 8,791 | Carlos Reyes | Jose Rosado | Don Wengert | Jose Rosado | | 471 | 580 | -109 |
| 1997-07-17 | vs KCA | 97 | W 11-3 | 40-57 | 4 | 9,489 | Steve Karsay | Tim Belcher | Steve Karsay | Tim Belcher | | 482 | 583 | -101 |
| 1997-07-18 | vs MIN | 98 | L 3-7 | 40-58 | 4 | 10,463 | Steve Wojciechowski | LaTroy Hawkins | LaTroy Hawkins | Steve Wojciechowski | | 485 | 590 | -105 |
| 1997-07-19 | vs MIN | 99 | L 6-7 | 40-59 | 4 | 14,763 | Brad Rigby | Dave Stevens | Greg Swindell | Don Wengert | Rick Aguilera | 491 | 597 | -106 |
| 1997-07-20 | vs MIN | 100 | L 0-1 | 40-60 | 4 | 20,651 | Carlos Reyes | Brad Radke | Brad Radke | Carlos Reyes | | 491 | 598 | -107 |
| 1997-07-22 | @ BOS | 101 | L 3-4 | 40-61 | 4 | 27,864 | Steve Karsay | Aaron Sele | Butch Henry | Buddy Groom | Heathcliff Slocumb | 494 | 602 | -108 |
| 1997-07-23 | @ BOS | 102 | W 5-2 | 41-61 | 4 | 29,213 | Don Wengert | Tim Wakefield | Don Wengert | Tim Wakefield | Billy Taylor | 499 | 604 | -105 |
| 1997-07-24 | @ BOS | 103 | L 0-3 | 41-62 | 4 | 29,312 | Brad Rigby | Jeff Suppan | Jeff Suppan | Brad Rigby | Heathcliff Slocumb | 499 | 607 | -108 |
| 1997-07-25 | @ CLE | 104 | W 2-1 | 42-62 | 4 | 42,945 | Carlos Reyes | Charles Nagy | Aaron Small | Michael Jackson | Billy Taylor | 501 | 608 | -107 |
| 1997-07-26 | @ CLE | 105 | L 3-6 | 42-63 | 4 | 42,925 | Steve Karsay | Jaret Wright | Jaret Wright | Steve Karsay | | 504 | 614 | -110 |
| 1997-07-27 | @ CLE | 106 | L 2-4 | 42-64 | 4 | 42,885 | Jimmy Haynes | Jason Jacome | Jason Jacome | Jimmy Haynes | Paul Assenmacher | 506 | 618 | -112 |
| 1997-07-28 | @ NYA | 107 | L 3-4 | 42-65 | 4 | 25,570 | Brad Rigby | David Cone | Mariano Rivera | Aaron Small | | 509 | 622 | -113 |
| 1997-07-29 | @ NYA | 108 | L 4-7 | 42-66 | 4 | 33,341 | Carlos Reyes | Dwight Gooden | Dwight Gooden | Carlos Reyes | Mariano Rivera | 513 | 629 | -116 |
| 1997-07-30 | @ NYA | 109 | L 0-7 | 42-67 | 4 | 35,480 | Steve Karsay | David Wells | David Wells | Steve Karsay | | 513 | 636 | -123 |
| 1997-07-31 | vs BAL | 110 | L 0-4 | 42-68 | 4 | 9,517 | Jimmy Haynes | Jimmy Key | Armando Benitez | Dane Johnson | | 513 | 640 | -127 |
| 1997-08-01 | vs BAL | 111 | W 2-1 | 43-68 | 4 | 14,187 | Brad Rigby | Scott Erickson | T.J. Mathews | Jesse Orosco | | 515 | 641 | -126 |
| 1997-08-02 | vs BAL | 112 | L 3-13 | 43-69 | 4 | 21,938 | Carlos Reyes | Mike Mussina | Mike Mussina | Carlos Reyes | | 518 | 654 | -136 |
| 1997-08-03 | vs BAL | 113 | L 5-7 | 43-70 | 4 | 17,066 | Don Wengert | Rick Krivda | Shawn Boskie | T.J. Mathews | Randy Myers | 523 | 661 | -138 |
| 1997-08-05 | vs CHA | 114 | L 0-3 | 43-71 | 4 | 11,676 | Steve Karsay | Doug Drabek | Doug Drabek | Steve Karsay | Matt Karchner | 523 | 664 | -141 |
| 1997-08-06 | vs CHA | 115 | W 3-2 | 44-71 | 4 | 11,601 | Jimmy Haynes | Jaime Navarro | T.J. Mathews | Jaime Navarro | Billy Taylor | 526 | 666 | -140 |
| 1997-08-07 | vs MIL | 116 | W 5-4 | 45-71 | 4 | 8,001 | Brad Rigby | Steve Woodard | Dane Johnson | Doug Jones | | 531 | 670 | -139 |
| 1997-08-09 | vs MIL | 117 | W 3-2 | 46-71 | 4 | 11,171 | Willie Adams | Jose Mercedes | T.J. Mathews | Bob Wickman | Billy Taylor | 534 | 672 | -138 |
| 1997-08-10 | vs MIL | 118 | W 4-3 | 47-72 | 4 | 0 | Don Wengert | Scott Karl | Billy Taylor | Bob Wickman | | 538 | 675 | -137 |
| 1997-08-10 | vs MIL | 119 | L 5-9 | 47-72 | 4 | 15,926 | Jimmy Haynes | Bryce Florie | Bryce Florie | Jimmy Haynes | | 543 | 684 | -141 |
| 1997-08-12 | @ BAL | 120 | L 0-8 | 47-73 | 4 | 46,925 | Carlos Reyes | Scott Erickson | Scott Erickson | Carlos Reyes | | 543 | 692 | -149 |
| 1997-08-13 | @ BAL | 121 | W 4-2 | 48-73 | 4 | 46,808 | Andrew Lorraine | Mike Mussina | Andrew Lorraine | Mike Mussina | Mike Mohler | 547 | 694 | -147 |
| 1997-08-14 | @ CHA | 122 | W 12-5 | 49-73 | 4 | 21,570 | Willie Adams | Carlos Castillo | Buddy Groom | Chuck McElroy | | 559 | 699 | -140 |
| 1997-08-15 | @ CHA | 123 | W 11-6 | 50-73 | 4 | 29,652 | Jimmy Haynes | James Baldwin | Jimmy Haynes | James Baldwin | | 570 | 705 | -135 |
| 1997-08-16 | @ MIL | 124 | L 5-6 | 50-74 | 4 | 17,031 | Don Wengert | Cal Eldred | Doug Jones | Mike Mohler | | 575 | 711 | -136 |
| 1997-08-17 | @ MIL | 125 | L 2-5 | 50-75 | 4 | 22,283 | Ariel Prieto | Steve Woodard | Steve Woodard | Ariel Prieto | Doug Jones | 577 | 716 | -139 |
| 1997-08-20 | vs BOS | 126 | L 5-7 | 50-77 | 4 | 0 | Jimmy Haynes | Tim Wakefield | Tim Wakefield | Jimmy Haynes | Butch Henry | 582 | 723 | -141 |
| 1997-08-20 | vs BOS | 127 | L 4-5 | 50-77 | 4 | 11,382 | Mike Oquist | Jeff Suppan | Joe Hudson | Don Wengert | Tom Gordon | 586 | 728 | -142 |
| 1997-08-21 | vs BOS | 128 | W 13-6 | 51-77 | 4 | 11,570 | Andrew Lorraine | Steve Avery | Andrew Lorraine | Steve Avery | | 599 | 734 | -135 |
| 1997-08-22 | vs CLE | 129 | L 3-5 | 51-78 | 4 | 11,451 | Ariel Prieto | Jaret Wright | Jaret Wright | Ariel Prieto | Jose Mesa | 602 | 739 | -137 |
| 1997-08-23 | vs CLE | 130 | L 4-7 | 51-79 | 4 | 17,066 | Brad Rigby | Orel Hershiser | Orel Hershiser | Brad Rigby | Jose Mesa | 606 | 746 | -140 |
| 1997-08-24 | vs CLE | 131 | W 4-1 | 52-79 | 4 | 20,074 | Jimmy Haynes | John Smiley | Jimmy Haynes | John Smiley | T.J. Mathews | 610 | 747 | -137 |
| 1997-08-26 | vs NYA | 132 | L 2-18 | 52-80 | 4 | 14,301 | Mike Oquist | Andy Pettitte | Andy Pettitte | Mike Oquist | | 612 | 765 | -153 |
| 1997-08-27 | vs NYA | 133 | W 8-7 | 53-80 | 4 | 18,079 | Andrew Lorraine | Hideki Irabu | T.J. Mathews | Jeff Nelson | | 620 | 772 | -152 |
| 1997-08-28 | @ LAN | 134 | L 1-7 | 53-81 | 4 | 51,392 | Eric Ludwick | Hideo Nomo | Hideo Nomo | Eric Ludwick | | 621 | 779 | -158 |
| 1997-08-29 | @ LAN | 135 | L 4-5 | 53-82 | 4 | 43,630 | Brad Rigby | Ismael Valdez | Antonio Osuna | T.J. Mathews | | 625 | 784 | -159 |
| 1997-08-30 | @ COL | 136 | L 3-4 | 53-83 | 4 | 48,308 | Jimmy Haynes | Frank Castillo | Jerry DiPoto | Mike Mohler | | 628 | 788 | -160 |
| 1997-08-31 | @ COL | 137 | L 4-10 | 53-84 | 4 | 48,041 | Mike Oquist | Roger Bailey | Darren Holmes | Mike Oquist | | 632 | 798 | -166 |
| 1997-09-01 | vs SFN | 138 | L 2-8 | 53-85 | 4 | 50,792 | Andrew Lorraine | Kirk Rueter | Kirk Rueter | Andrew Lorraine | | 634 | 806 | -172 |
| 1997-09-03 | vs SFN | 139 | W 12-3 | 54-85 | 4 | 32,408 | Brad Rigby | Danny Darwin | Brad Rigby | Danny Darwin | Aaron Small | 646 | 809 | -163 |
| 1997-09-04 | @ KCA | 140 | L 6-7 | 54-86 | 4 | 13,891 | Jimmy Haynes | Tim Belcher | Gregg Olson | Don Wengert | | 652 | 816 | -164 |
| 1997-09-05 | @ KCA | 141 | W 9-6 | 55-86 | 4 | 13,299 | Mike Oquist | Glendon Rusch | Mike Oquist | Hector Carrasco | Billy Taylor | 661 | 822 | -161 |
| 1997-09-06 | @ KCA | 142 | W 9-3 | 56-86 | 4 | 18,853 | Andrew Lorraine | Kevin Appier | Andrew Lorraine | Kevin Appier | Don Wengert | 670 | 825 | -155 |
| 1997-09-07 | @ KCA | 143 | W 9-4 | 57-86 | 4 | 14,123 | Eric Ludwick | Jose Rosado | Eric Ludwick | Jose Rosado | | 679 | 829 | -150 |
| 1997-09-08 | @ MIN | 144 | L 2-7 | 57-87 | 4 | 9,363 | Dave Telgheder | Dan Serafini | Dan Serafini | Dave Telgheder | | 681 | 836 | -155 |
| 1997-09-09 | @ MIN | 145 | W 5-1 | 58-87 | 4 | 9,705 | Jimmy Haynes | LaTroy Hawkins | Jimmy Haynes | LaTroy Hawkins | | 686 | 837 | -151 |
| 1997-09-10 | vs TOR | 146 | W 3-2 | 59-87 | 4 | 4,764 | Mike Oquist | Woody Williams | T.J. Mathews | Dan Plesac | | 689 | 839 | -150 |
| 1997-09-11 | vs TOR | 147 | W 8-7 | 60-87 | 4 | 6,135 | Andrew Lorraine | Pat Hentgen | T.J. Mathews | Kelvim Escobar | | 697 | 846 | -149 |
| 1997-09-12 | vs DET | 148 | L 2-7 | 60-88 | 4 | 11,775 | Eric Ludwick | Greg Keagle | Greg Keagle | Eric Ludwick | Dan Miceli | 699 | 853 | -154 |
| 1997-09-13 | vs DET | 149 | W 4-2 | 61-88 | 4 | 20,482 | Dave Telgheder | Willie Blair | Dave Telgheder | Willie Blair | T.J. Mathews | 703 | 855 | -152 |
| 1997-09-14 | vs DET | 150 | L 5-6 | 61-89 | 4 | 16,440 | Jimmy Haynes | Scott Sanders | Scott Sanders | Jimmy Haynes | Todd Jones | 708 | 861 | -153 |
| 1997-09-15 | vs DET | 151 | L 3-6 | 61-90 | 4 | 4,651 | Mike Oquist | Justin Thompson | Justin Thompson | Mike Oquist | Todd Jones | 711 | 867 | -156 |
| 1997-09-17 | @ ANA | 152 | L 4-8 | 61-91 | 4 | 16,800 | Eric Ludwick | Allen Watson | Allen Watson | Eric Ludwick | | 715 | 875 | -160 |
| 1997-09-18 | @ ANA | 153 | W 7-3 | 62-91 | 4 | 26,689 | Dave Telgheder | Jason Dickson | Dave Telgheder | Jason Dickson | | 722 | 878 | -156 |
| 1997-09-19 | vs SEA | 154 | L 4-9 | 62-92 | 4 | 16,373 | Jimmy Haynes | Jamie Moyer | Jamie Moyer | Jimmy Haynes | | 726 | 887 | -161 |
| 1997-09-20 | vs SEA | 155 | W 4-3 | 63-92 | 4 | 26,619 | Mike Oquist | Omar Olivares | Aaron Small | Felipe Lira | | 730 | 890 | -160 |
| 1997-09-21 | vs SEA | 156 | L 2-9 | 63-93 | 4 | 20,737 | Brad Rigby | Ken Cloude | Ken Cloude | Brad Rigby | | 732 | 899 | -167 |
| 1997-09-22 | vs SEA | 157 | L 2-4 | 63-94 | 4 | 11,275 | Eric Ludwick | Jeff Fassero | Jeff Fassero | Eric Ludwick | Heathcliff Slocumb | 734 | 903 | -169 |
| 1997-09-23 | vs TEX | 158 | L 6-14 | 63-95 | 4 | 9,968 | Dave Telgheder | John Burkett | John Burkett | Dave Telgheder | | 740 | 917 | -177 |
| 1997-09-24 | vs TEX | 159 | L 4-8 | 63-96 | 4 | 12,190 | Jimmy Haynes | Darren Oliver | Darren Oliver | Jimmy Haynes | | 744 | 925 | -181 |
| 1997-09-26 | @ SEA | 160 | W 8-5 | 64-96 | 4 | 55,560 | Mike Oquist | Jamie Moyer | Mike Oquist | Jamie Moyer | T.J. Mathews | 752 | 930 | -178 |
| 1997-09-27 | @ SEA | 161 | L 3-9 | 64-97 | 4 | 50,443 | Brad Rigby | Omar Olivares | Randy Johnson | Brad Rigby | | 755 | 939 | -184 |
| 1997-09-28 | @ SEA | 162 | W 9-7 | 65-97 | 4 | 55,910 | Dave Telgheder | Jeff Fassero | Aaron Small | Norm Charlton | Billy Taylor | 764 | 946 | -182 |